| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000014362 | 0.020 | 0.0190 | 7.0e-03 | 0.005 | 0.001 | -0.001 | 0.000 | 7.5e-02 | 2.6e-01 | 5.3e-01 | 3.3e-01 |
| 2 | BLA | gene expression | ENSRNOG00000014362 | 0.201 | 0.1120 | 3.3e-10 | 0.162 | 0.174 | 0.151 | 0.160 | 4.9e-09 | 1.3e-09 | 1.8e-08 | 6.2e-09 |
| 3 | Brain | gene expression | ENSRNOG00000014362 | 0.260 | 0.1300 | 0.0e+00 | 0.211 | 0.010 | 0.215 | 0.201 | 2.5e-19 | 3.6e-02 | 1.0e-19 | 2.4e-18 |
| 4 | Brain | isoform ratio | ENSRNOT00000019550 | 0.033 | 0.0243 | 2.9e-04 | 0.043 | 0.007 | 0.030 | 0.016 | 7.3e-05 | 7.3e-02 | 8.3e-04 | 1.1e-02 |
| 5 | IL | gene expression | ENSRNOG00000014362 | 0.170 | 0.1140 | 2.7e-04 | 0.150 | 0.143 | 0.121 | 0.154 | 1.9e-04 | 2.7e-04 | 8.0e-04 | 1.6e-04 |
| 6 | LHb | gene expression | ENSRNOG00000014362 | 0.393 | 0.2518 | 8.8e-07 | 0.207 | 0.255 | 0.258 | 0.256 | 1.2e-05 | 9.1e-07 | 7.7e-07 | 8.6e-07 |
| 7 | Liver | gene expression | ENSRNOG00000014362 | 0.064 | 0.0540 | 1.7e-06 | 0.025 | 0.040 | 0.032 | 0.029 | 7.4e-04 | 2.8e-05 | 1.6e-04 | 3.1e-04 |
| 8 | NAcc | alternative polyA | ENSRNOT00000109846 | 0.029 | 0.0240 | 6.3e-03 | 0.011 | 0.028 | 0.014 | 0.021 | 4.7e-02 | 3.5e-03 | 3.1e-02 | 1.0e-02 |
| 9 | NAcc | gene expression | ENSRNOG00000014362 | 0.067 | 0.0430 | 1.0e-06 | 0.072 | 0.084 | 0.065 | 0.077 | 4.6e-06 | 7.7e-07 | 1.4e-05 | 2.2e-06 |
| 10 | PL | gene expression | ENSRNOG00000014362 | 0.126 | 0.0764 | 1.9e-11 | 0.109 | 0.151 | 0.135 | 0.132 | 1.1e-08 | 1.4e-11 | 2.0e-10 | 3.1e-10 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Delay discounting water rate 0 sec | 16.2 | 25.8 | 31.0 | -5.1 | 5.5 | 4.7 | 5.5 | 0.0 | 5.3 | 5.6 | -5.5 | 5.5 | 5.5 |
| Delay discounting time to switch 0 sec | 11.4 | 17.4 | 21.2 | 4.3 | -4.5 | -3.6 | -4.6 | 0.0 | -4.3 | -4.6 | 4.5 | -4.5 | -4.5 |
| Time in open arm after self-admin | 9.4 | 10.3 | 13.3 | -2.6 | 3.5 | 3.3 | 3.6 | 0.0 | 3.6 | 3.4 | -3.4 | 3.4 | 3.5 |
| Extensor digitorum longus weight | 9.0 | 36.2 | 42.9 | -6.2 | 6.3 | 6.4 | 6.4 | 0.0 | 6.6 | 6.2 | -6.4 | 6.4 | 6.3 |
| Length with tail | 8.7 | 31.9 | 37.4 | -6.1 | 6.1 | 5.4 | 5.8 | 0.0 | 6.0 | 6.1 | -6.0 | 6.1 | 6.1 |
| Pavlov. Cond. intertrial magazine entries | 7.9 | 9.5 | 11.9 | -3.0 | 3.3 | 3.0 | 3.3 | 0.0 | 3.4 | 3.3 | -3.3 | 3.3 | 3.3 |
| Delay discounting total patch changes 0 sec | 7.5 | 12.1 | 14.5 | -3.5 | 3.8 | 3.4 | 3.6 | 0.0 | 3.7 | 3.8 | -3.7 | 3.7 | 3.8 |
| Time in closed arm before self-admin | 7.4 | 8.4 | 11.7 | 2.7 | -3.1 | -2.7 | -3.4 | 0.0 | -3.2 | -3.0 | 3.1 | -3.1 | -3.1 |
| Indifference point AUC | 6.5 | 7.6 | 9.8 | -3.0 | 3.0 | 2.3 | 3.1 | 0.0 | 3.0 | 3.0 | -2.8 | 2.8 | 3.1 |
| Indifference point 0 sec | 6.2 | 10.0 | 12.0 | -3.1 | 3.5 | 3.1 | 3.3 | 0.0 | 3.4 | 3.5 | -3.3 | 3.3 | 3.4 |
| Delay discounting total patch changes 6 sec | 6.2 | 9.4 | 11.7 | -3.2 | 3.4 | 2.6 | 3.4 | 0.0 | 3.4 | 3.4 | -3.1 | 3.2 | 3.4 |
| Time in closed arm after self-admin | 6.0 | 6.2 | 8.2 | 2.2 | -2.6 | -2.9 | -2.9 | 0.0 | -2.8 | -2.5 | 2.6 | -2.6 | -2.6 |
| Time in open arm before self-admin | 5.9 | 6.2 | 7.8 | -2.5 | 2.7 | 2.0 | 2.8 | 0.0 | 2.6 | 2.8 | -2.7 | 2.7 | 2.8 |
| Length without tail | 5.6 | 12.2 | 14.5 | -3.8 | 3.8 | 3.5 | 3.4 | 0.0 | 3.8 | 3.7 | -3.6 | 3.7 | 3.8 |
| Pavlov. Cond. change in total contacts | 5.6 | 7.8 | 9.6 | 3.1 | -3.0 | -2.7 | -2.9 | 0.0 | -3.0 | -2.9 | 3.0 | -3.0 | -3.0 |
| Delta time to tail flick, test, before/after SA | 5.2 | 4.7 | 8.2 | -2.9 | 2.3 | 1.7 | 2.2 | 0.0 | 2.3 | 2.3 | -2.2 | 2.2 | 2.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 5.0 | 6.5 | 8.8 | 2.8 | -2.6 | -3.0 | -2.6 | 0.0 | -2.7 | -2.5 | 2.7 | -2.7 | -2.6 |
| Time to tail flick, test, after self-admin | 4.9 | 5.0 | 6.3 | -2.4 | 2.4 | 2.0 | 2.5 | 0.0 | 2.4 | 2.4 | -2.3 | 2.4 | 2.4 |
| Delay discounting water rate 12 sec | 4.7 | 7.0 | 10.3 | -2.6 | 3.0 | 1.6 | 2.8 | 0.0 | 2.7 | 3.2 | -3.0 | 3.0 | 3.0 |
| Tail length | 4.6 | 14.0 | 16.6 | -3.9 | 4.0 | 3.4 | 4.0 | 0.0 | 3.9 | 4.1 | -4.1 | 4.1 | 4.0 |
| Pavlov. Cond. index score | 4.3 | 5.7 | 7.7 | 2.6 | -2.4 | -2.8 | -2.4 | 0.0 | -2.5 | -2.3 | 2.5 | -2.5 | -2.4 |
| Pavlov. Cond. intertrial magazine entries | 4.2 | 5.5 | 6.6 | -2.6 | 2.5 | 2.4 | 2.2 | 0.0 | 2.3 | 2.6 | -2.5 | 2.6 | 2.6 |
| Reaction time trials AUC | 4.1 | 5.9 | 7.5 | -2.4 | 2.6 | 2.7 | 2.4 | 0.0 | 2.6 | 2.6 | -2.6 | 2.6 | 2.5 |
| Reaction time number correct | 4.0 | 5.7 | 7.6 | -2.4 | 2.5 | 2.8 | 2.4 | 0.0 | 2.5 | 2.5 | -2.5 | 2.5 | 2.5 |
| Reaction time trials correct on left | 4.0 | 5.7 | 7.6 | -2.4 | 2.5 | 2.8 | 2.4 | 0.0 | 2.5 | 2.5 | -2.5 | 2.5 | 2.5 |
| Reaction time trials on left | 4.0 | 5.7 | 7.5 | -2.4 | 2.5 | 2.7 | 2.4 | 0.0 | 2.5 | 2.5 | -2.6 | 2.5 | 2.5 |
| Reaction time trials completed | 4.0 | 5.7 | 7.5 | -2.4 | 2.5 | 2.7 | 2.4 | 0.0 | 2.5 | 2.5 | -2.6 | 2.5 | 2.5 |
| Pavlov. Cond. latency score | 3.8 | 4.9 | 7.4 | 2.4 | -2.2 | -2.7 | -2.2 | 0.0 | -2.3 | -2.1 | 2.4 | -2.4 | -2.2 |
| Delay discounting water rate 6 sec | 3.7 | 5.4 | 7.0 | -2.4 | 2.6 | 1.7 | 2.4 | 0.0 | 2.5 | 2.6 | -2.6 | 2.6 | 2.6 |
| Bone: cortical apparent density | 3.7 | 4.9 | 6.2 | -2.2 | 2.4 | 2.3 | 2.1 | 0.0 | 2.2 | 2.5 | -2.4 | 2.4 | 2.4 |
| Bone: cortical tissue density | 3.7 | 4.8 | 6.2 | -2.2 | 2.4 | 2.2 | 2.1 | 0.0 | 2.2 | 2.5 | -2.4 | 2.4 | 2.4 |
| Delay discounting total patch changes 12 sec | 3.6 | 4.8 | 6.3 | -2.0 | 2.5 | 2.1 | 2.3 | 0.0 | 2.4 | 2.5 | -2.3 | 2.3 | 2.4 |
| Delay disc. indifference point, 2s delay | 3.6 | 4.0 | 5.8 | 2.3 | -2.1 | -1.6 | -2.4 | 0.0 | -2.1 | -2.1 | 2.0 | -2.1 | -2.2 |
| Pavlov. Cond. magazine entry latency | 3.4 | 3.9 | 6.7 | 2.2 | -1.9 | -2.6 | -1.9 | 0.0 | -1.9 | -1.9 | 2.1 | -2.1 | -2.0 |
| Pavlov. Cond. response bias | 3.3 | 4.5 | 6.6 | 2.3 | -2.1 | -2.6 | -2.2 | 0.0 | -2.3 | -2.0 | 2.2 | -2.2 | -2.1 |
| Delay discounting water rate 18 sec | 3.2 | 4.2 | 6.0 | -2.0 | 2.4 | 1.4 | 2.0 | 0.0 | 2.1 | 2.5 | -2.3 | 2.3 | 2.3 |
| Context. condit. distance diff. score | 3.2 | 3.9 | 5.5 | -2.0 | 2.0 | 2.3 | 2.0 | 0.0 | 2.0 | 2.0 | -2.1 | 2.1 | 2.0 |
| Pavlov. Cond. lever contacts | 3.1 | 4.4 | 5.7 | 2.2 | -2.1 | -2.4 | -2.2 | 0.0 | -2.3 | -2.1 | 2.2 | -2.2 | -2.1 |
| Pavlov. Cond. lever latency | 2.9 | 4.0 | 5.0 | -2.1 | 2.0 | 2.2 | 2.2 | 0.0 | 2.2 | 2.0 | -2.1 | 2.1 | 2.0 |
| Pavlov. Cond. magazine entry number | 2.9 | 3.6 | 5.5 | -2.3 | 1.9 | 2.4 | 1.8 | 0.0 | 1.8 | 1.8 | -2.1 | 2.1 | 1.9 |
| Intermitt. access day 1 inactive lever presses | 2.8 | 3.0 | 3.9 | -1.7 | 1.9 | 1.7 | 1.9 | 0.0 | 1.8 | 2.0 | -1.8 | 1.8 | 1.9 |
| Left kidney weight | 2.7 | 7.8 | 9.2 | -3.0 | 3.0 | 2.7 | 2.9 | 0.0 | 2.9 | 3.0 | -3.0 | 3.0 | 3.0 |
| Delay discounting total patch changes 18 sec | 2.6 | 3.5 | 4.4 | -1.8 | 2.1 | 1.9 | 2.0 | 0.0 | 2.1 | 2.1 | -1.9 | 1.9 | 2.0 |
| Time >=10cm from walls, locomotor time 1 | 2.6 | 2.6 | 4.2 | -2.1 | 1.8 | 1.1 | 1.9 | 0.0 | 1.8 | 1.6 | -1.5 | 1.6 | 1.8 |
| Run reversals in cocaine runway, females | 2.6 | 2.6 | 3.4 | 1.6 | -1.8 | -1.5 | -1.3 | 0.0 | -1.8 | -1.8 | 1.7 | -1.7 | -1.8 |
| Liver weight, left | 2.5 | 4.0 | 5.0 | -2.2 | 2.1 | 1.7 | 2.2 | 0.0 | 2.1 | 2.1 | -2.1 | 2.1 | 2.2 |
| Delay discounting water rate 24 sec | 2.5 | 3.4 | 5.1 | -1.8 | 2.1 | 0.8 | 2.0 | 0.0 | 1.9 | 2.3 | -2.0 | 2.0 | 2.1 |
| Stereotopy head waving bouts, day 7 | 2.5 | 2.8 | 3.9 | -1.6 | 1.7 | 2.0 | 1.8 | 0.0 | 1.9 | 1.7 | -1.8 | 1.8 | 1.7 |
| Locomotion in novel chamber | 2.5 | 3.1 | 4.4 | -1.7 | 2.0 | 1.4 | 1.6 | 0.0 | 1.8 | 2.1 | -2.0 | 2.0 | 2.0 |
| Time >=10cm from walls, locomotor time 2 | 2.4 | 2.6 | 3.3 | -1.7 | 1.7 | 1.7 | 1.7 | 0.0 | 1.8 | 1.6 | -1.6 | 1.6 | 1.7 |
| Cu content in liver | 2.4 | 2.9 | 3.7 | 1.8 | -1.8 | -1.9 | -1.7 | 0.0 | -1.7 | -1.8 | 1.8 | -1.8 | -1.8 |
| Cocaine response before conditioning | 2.3 | 2.8 | 4.1 | 1.6 | -1.7 | -2.0 | -2.0 | 0.0 | -1.9 | -1.6 | 1.8 | -1.7 | -1.6 |
| Time to tail flick, vehicle, before self-admin | 2.3 | 2.3 | 3.0 | -1.7 | 1.7 | 1.1 | 1.7 | 0.0 | 1.6 | 1.7 | -1.5 | 1.5 | 1.7 |
| Locomotion velocity, session 8 | 2.2 | 2.6 | 3.1 | -1.8 | 1.7 | 1.5 | 1.7 | 0.0 | 1.7 | 1.7 | -1.7 | 1.7 | 1.7 |
| Total heroin consumption | 2.2 | 2.7 | 3.7 | -1.7 | 1.7 | 1.7 | 1.8 | 0.0 | 1.9 | 1.6 | -1.7 | 1.7 | 1.7 |
| Reaction time mean | 2.1 | 2.8 | 3.9 | 1.6 | -1.8 | -1.9 | -2.0 | 0.0 | -1.9 | -1.7 | 1.7 | -1.7 | -1.7 |
| Reaction time premature initiations | 2.1 | 3.0 | 5.6 | -1.6 | 1.7 | 2.4 | 1.8 | 0.0 | 1.7 | 1.7 | -1.8 | 1.8 | 1.7 |
| Condit. Reinf. inactive responses | 2.1 | 2.5 | 3.7 | -1.4 | 1.8 | 1.0 | 1.8 | 0.0 | 1.9 | 1.8 | -1.6 | 1.6 | 1.7 |
| Soleus weight | 2.0 | 5.9 | 8.3 | -2.5 | 2.5 | 2.3 | 2.8 | 0.0 | 2.9 | 2.4 | -2.4 | 2.5 | 2.5 |
| Progressive ratio test 1 inactive lever presses | 1.9 | 2.1 | 2.8 | -1.3 | 1.6 | 1.4 | 1.4 | 0.0 | 1.4 | 1.7 | -1.6 | 1.6 | 1.6 |
| Bone: post-yield work | 1.9 | 2.6 | 4.6 | -1.5 | 1.6 | 2.1 | 1.6 | 0.0 | 1.6 | 1.6 | -1.7 | 1.7 | 1.6 |
| Epididymis fat weight | 1.8 | 4.2 | 5.8 | 1.8 | -2.2 | -2.4 | -1.9 | 0.0 | -2.3 | -2.3 | 2.2 | -2.2 | -2.1 |
| Locomotor testing rearing | 1.8 | 2.9 | 3.8 | 1.9 | -1.7 | -1.7 | -1.9 | 0.0 | -1.7 | -1.7 | 1.9 | -1.9 | -1.7 |
| Reaction time num false alarms AUC | 1.8 | 2.5 | 3.3 | -1.8 | 1.7 | 1.6 | 1.5 | 0.0 | 1.6 | 1.7 | -1.7 | 1.8 | 1.7 |
| Median of all reaction times | 1.8 | 2.5 | 3.4 | 1.5 | -1.7 | -1.8 | -1.8 | 0.0 | -1.8 | -1.6 | 1.6 | -1.6 | -1.6 |
| Condit. Reinf. lever presses | 1.8 | 2.5 | 3.0 | 1.7 | -1.6 | -1.5 | -1.7 | 0.0 | -1.7 | -1.6 | 1.6 | -1.6 | -1.6 |
| Reaction time num false alarms | 1.7 | 2.3 | 2.7 | -1.7 | 1.6 | 1.5 | 1.5 | 0.0 | 1.6 | 1.6 | -1.6 | 1.7 | 1.6 |
| BMI with tail | 1.6 | 5.2 | 12.1 | 2.1 | -2.2 | -3.5 | -2.0 | 0.0 | -2.4 | -2.3 | 2.4 | -2.4 | -2.2 |
| Conditioned locomotion | 1.6 | 2.0 | 2.4 | -1.5 | 1.5 | 1.3 | 1.4 | 0.0 | 1.5 | 1.5 | -1.5 | 1.5 | 1.5 |
| Stereotopy head waving duration, day 7 | 1.6 | 1.9 | 2.9 | -1.4 | 1.4 | 1.7 | 1.5 | 0.0 | 1.6 | 1.3 | -1.5 | 1.4 | 1.4 |
| Change in fecal boli incidents, locomotor task | 1.6 | 1.5 | 2.2 | -1.3 | 1.4 | 0.7 | 1.4 | 0.0 | 1.2 | 1.5 | -1.3 | 1.3 | 1.4 |
| Condit. Reinf. active-inactive response ratio | 1.5 | 1.6 | 2.1 | 1.2 | -1.3 | -1.2 | -1.4 | 0.0 | -1.4 | -1.4 | 1.4 | -1.4 | -1.3 |
| Delay disc. indifference point, 16s delay | 1.5 | 1.5 | 2.4 | 1.3 | -1.3 | -1.1 | -1.6 | 0.0 | -1.3 | -1.2 | 1.3 | -1.3 | -1.3 |
| Body weight | 1.4 | 6.0 | 8.3 | -2.9 | 2.8 | 1.3 | 2.6 | 0.0 | 2.5 | 2.8 | -2.6 | 2.6 | 2.8 |
| Mean num. licks in bursts | 1.4 | 1.6 | 2.2 | -1.5 | 1.4 | 0.9 | 1.5 | 0.0 | 1.5 | 1.4 | -1.3 | 1.3 | 1.4 |
| Intermittent access intake day 1-15 change | 1.4 | 1.4 | 1.9 | 1.2 | -1.2 | -1.4 | -1.1 | 0.0 | -1.2 | -1.2 | 1.3 | -1.3 | -1.2 |
| Right kidney weight | 1.3 | 3.7 | 4.4 | -2.1 | 2.1 | 1.6 | 2.0 | 0.0 | 2.0 | 2.1 | -2.1 | 2.1 | 2.1 |
| Delay discounting total patch changes 24 sec | 1.3 | 1.6 | 2.1 | -1.3 | 1.5 | 1.0 | 1.2 | 0.0 | 1.4 | 1.4 | -1.3 | 1.3 | 1.4 |
| Reaction time mean AUC | 1.3 | 1.7 | 2.4 | 1.2 | -1.4 | -1.5 | -1.6 | 0.0 | -1.5 | -1.3 | 1.3 | -1.3 | -1.3 |
| Std. dev. reaction times | 1.3 | 1.7 | 2.7 | 1.3 | -1.4 | -1.3 | -1.6 | 0.0 | -1.5 | -1.3 | 1.3 | -1.3 | -1.4 |
| Intermittent access intake escalation | 1.3 | 1.3 | 2.1 | 1.2 | -1.2 | -1.5 | -0.8 | 0.0 | -1.2 | -1.2 | 1.2 | -1.2 | -1.2 |
| Delay discount hyperbolic model param | 1.3 | 1.3 | 2.0 | -1.3 | 1.2 | 1.1 | 1.4 | 0.0 | 1.2 | 1.1 | -1.2 | 1.2 | 1.2 |
| Progressive ratio | 1.3 | 1.5 | 2.1 | 1.4 | -1.3 | -1.5 | -1.2 | 0.0 | -1.4 | -1.2 | 1.2 | -1.2 | -1.3 |
| Light reinforcement 2 | 1.2 | 1.5 | 2.0 | 0.8 | -1.4 | -1.2 | -1.4 | 0.0 | -1.4 | -1.4 | 1.4 | -1.3 | -1.3 |
| Bone: endosteal estimation | 1.2 | 2.7 | 4.3 | 2.1 | -1.8 | -1.0 | -1.8 | 0.0 | -1.8 | -1.7 | 1.6 | -1.7 | -1.9 |
| Bone: marrow area | 1.2 | 2.7 | 4.2 | 2.1 | -1.8 | -0.9 | -1.8 | 0.0 | -1.8 | -1.7 | 1.6 | -1.7 | -1.9 |
| Active lever presses in extinction session 6 | 1.2 | 1.1 | 2.0 | -0.2 | 1.2 | 1.4 | 1.1 | 0.0 | 1.1 | 1.2 | -1.2 | 1.2 | 1.1 |
| Area under the delay curve | 1.2 | 1.3 | 2.0 | 1.2 | -1.2 | -1.0 | -1.4 | 0.0 | -1.2 | -1.1 | 1.2 | -1.2 | -1.2 |
| Total resting periods, locomotor time 1 | 1.2 | 1.4 | 1.9 | 1.2 | -1.3 | -0.8 | -1.2 | 0.0 | -1.2 | -1.4 | 1.3 | -1.3 | -1.3 |
| Water consumed over 24 hours | 1.1 | 1.3 | 1.9 | -0.9 | 1.3 | 0.9 | 1.1 | 0.0 | 1.1 | 1.4 | -1.3 | 1.3 | 1.2 |
| Intermittent access terminal intake (last 3 days) | 1.1 | 1.2 | 1.8 | 1.2 | -1.1 | -1.3 | -1.0 | 0.0 | -1.1 | -1.2 | 1.2 | -1.2 | -1.2 |
| Delay disc. indifference point, 24s delay | 1.1 | 1.1 | 1.6 | 1.1 | -1.1 | -1.0 | -1.3 | 0.0 | -1.1 | -1.0 | 1.1 | -1.1 | -1.1 |
| Number of licking bursts | 1.0 | 1.2 | 1.8 | 1.4 | -1.1 | -0.9 | -1.2 | 0.0 | -1.2 | -1.1 | 1.1 | -1.1 | -1.2 |
| Degree of sensitization stereotypy | 1.0 | 1.1 | 1.8 | -1.1 | 1.1 | 1.4 | 1.1 | 0.0 | 1.2 | 1.0 | -1.1 | 1.1 | 1.1 |
| Time in novel zone, hab. session 2 | 1.0 | 1.0 | 1.5 | 1.2 | -1.0 | -0.9 | -1.1 | 0.0 | -1.1 | -0.9 | 1.0 | -1.0 | -1.0 |
| Delta time in open arm before/after self-admin | 1.0 | 0.9 | 1.3 | -0.9 | 1.0 | 1.0 | 1.1 | 0.0 | 1.1 | 0.9 | -1.0 | 1.0 | 1.0 |
| Delta ambulatory time before/after self-admin | 1.0 | 1.1 | 1.9 | -1.2 | 1.0 | 1.4 | 1.2 | 0.0 | 1.0 | 1.0 | -1.2 | 1.1 | 0.9 |
| Ambulatory time before self-admin | 1.0 | 1.1 | 2.4 | 1.1 | -1.0 | -1.6 | -1.0 | 0.0 | -1.0 | -1.0 | 1.1 | -1.1 | -1.0 |
| Bouts of movement, locomotor time 1 | 1.0 | 1.1 | 1.6 | 1.1 | -1.2 | -0.7 | -1.1 | 0.0 | -1.1 | -1.2 | 1.2 | -1.2 | -1.2 |
| Seeking ratio, punishment vs. effort | 1.0 | 1.2 | 2.6 | -1.0 | 1.1 | 1.6 | 1.1 | 0.0 | 1.2 | 1.0 | -1.0 | 1.0 | 1.1 |
| Fe content in liver | 1.0 | 1.1 | 1.6 | 1.1 | -1.2 | -0.7 | -1.2 | 0.0 | -1.2 | -1.3 | 1.1 | -1.1 | -1.2 |
| K content in liver | 1.0 | 1.0 | 1.7 | -1.3 | 1.1 | 0.3 | 1.1 | 0.0 | 1.1 | 1.1 | -1.0 | 1.0 | 1.2 |
| Tibialis anterior weight | 0.9 | 3.1 | 4.6 | -1.6 | 1.8 | 2.0 | 2.1 | 0.0 | 2.1 | 1.8 | -1.8 | 1.8 | 1.8 |
| Time in novel zone, hab. session 1 | 0.9 | 0.8 | 1.8 | 0.9 | -0.8 | -1.3 | -1.1 | 0.0 | -1.1 | -0.7 | 0.9 | -0.9 | -0.8 |
| Novelty place preference | 0.9 | 0.9 | 1.4 | 1.2 | -1.0 | -0.6 | -0.9 | 0.0 | -0.9 | -1.0 | 1.0 | -1.0 | -1.1 |
| Bone: stiffness | 0.9 | 1.4 | 2.8 | -0.9 | 1.2 | 1.7 | 1.3 | 0.0 | 1.3 | 1.2 | -1.3 | 1.2 | 1.1 |
| Time to tail flick, vehicle, after self-admin | 0.9 | 0.9 | 1.1 | -1.0 | 1.0 | 0.9 | 1.1 | 0.0 | 1.1 | 1.0 | -1.0 | 1.0 | 1.1 |
| Delay discount exponential model param | 0.9 | 1.0 | 1.5 | -1.1 | 1.0 | 1.0 | 1.2 | 0.0 | 1.1 | 1.0 | -1.0 | 1.0 | 1.0 |
| Latency to leave start box in cocaine runway | 0.9 | 1.0 | 1.4 | 1.2 | -1.0 | -1.0 | -1.1 | 0.0 | -1.0 | -1.0 | 1.0 | -1.0 | -1.0 |
| Co content in liver | 0.9 | 1.1 | 1.6 | -0.9 | 1.1 | 1.0 | 1.3 | 0.0 | 1.3 | 1.2 | -1.1 | 1.1 | 1.1 |
| BMI without tail | 0.8 | 1.6 | 4.4 | 1.1 | -1.2 | -2.1 | -1.1 | 0.0 | -1.5 | -1.2 | 1.3 | -1.2 | -1.2 |
| Food consumed during 24 hour testing period | 0.8 | 1.0 | 1.3 | -1.0 | 1.1 | 0.7 | 1.1 | 0.0 | 1.1 | 1.1 | -1.1 | 1.1 | 1.1 |
| Conditioned reinforcement - actives | 0.8 | 0.8 | 1.1 | -0.8 | 1.0 | 0.9 | 0.8 | 0.0 | 0.9 | 1.1 | -1.0 | 1.0 | 1.0 |
| Intermittent access day 15 total infusions | 0.8 | 0.9 | 2.1 | 1.0 | -1.0 | -1.4 | -0.6 | 0.0 | -1.0 | -1.0 | 1.1 | -1.0 | -1.0 |
| Locomotion distance, session 7 | 0.8 | 1.0 | 1.1 | 1.0 | -1.1 | -0.9 | -1.1 | 0.0 | -1.0 | -1.1 | 1.0 | -1.1 | -1.1 |
| Distance traveled before self-admin | 0.8 | 0.8 | 1.3 | 0.7 | -0.9 | -1.1 | -1.2 | 0.0 | -1.0 | -0.9 | 1.0 | -1.0 | -0.9 |
| Distance moved, locomotor task time 1 | 0.8 | 0.9 | 1.3 | 1.0 | -1.1 | -0.7 | -1.1 | 0.0 | -1.1 | -1.1 | 1.0 | -1.0 | -1.0 |
| Latency to leave start box in cocaine runway, M | 0.8 | 0.7 | 1.4 | 1.2 | -0.9 | -0.5 | -1.0 | 0.0 | -0.9 | -0.9 | 0.9 | -0.9 | -0.9 |
| Reaction time omissions | 0.7 | 1.0 | 1.5 | -1.1 | 1.1 | 0.7 | 0.7 | 0.0 | 1.0 | 1.2 | -1.2 | 1.2 | 1.1 |
| Short access total infusions | 0.7 | 0.8 | 1.2 | 1.0 | -0.9 | -1.1 | -0.8 | 0.0 | -1.0 | -0.8 | 0.9 | -0.9 | -0.9 |
| Novel to familiar place preference ratio | 0.7 | 0.8 | 1.1 | 1.1 | -1.0 | -0.5 | -0.9 | 0.0 | -0.8 | -1.0 | 1.0 | -1.0 | -1.0 |
| Bone: elastic work | 0.7 | 0.9 | 1.4 | 1.1 | -1.1 | -0.4 | -1.2 | 0.0 | -1.1 | -1.0 | 0.9 | -0.9 | -1.1 |
| Diff in mean of infusions in LGA sessions | 0.7 | 0.7 | 1.3 | -0.6 | 0.9 | 1.1 | 1.2 | 0.0 | 1.1 | 0.8 | -0.8 | 0.8 | 0.9 |
| Baseline Anxiety | 0.6 | 0.7 | 1.4 | 0.7 | -0.8 | -1.2 | -0.8 | 0.0 | -0.8 | -0.9 | 0.9 | -0.9 | -0.8 |
| Compulsive drug intake | 0.6 | 0.6 | 0.9 | -0.9 | 0.8 | 0.8 | 0.5 | 0.0 | 0.8 | 0.8 | -0.8 | 0.8 | 0.9 |
| Number of responses in last shaping day | 0.6 | 0.6 | 0.9 | 0.9 | -0.9 | -0.5 | -1.0 | 0.0 | -0.8 | -0.8 | 0.8 | -0.9 | -0.9 |
| Locomotion distance, session 2 | 0.6 | 0.9 | 2.0 | 1.0 | -0.9 | -1.4 | -0.9 | 0.0 | -0.9 | -0.8 | 1.0 | -1.0 | -0.9 |
| Bone: cortical thickness | 0.6 | 1.1 | 2.4 | -1.0 | 0.9 | 1.5 | 1.2 | 0.0 | 1.2 | 0.9 | -1.0 | 1.0 | 0.9 |
| Bone: cortical thickness | 0.6 | 0.7 | 1.8 | -0.5 | 0.8 | 1.3 | 0.9 | 0.0 | 0.9 | 0.8 | -0.9 | 0.8 | 0.7 |
| Liver weight, right | 0.5 | 0.9 | 1.4 | -1.0 | 1.1 | 0.1 | 1.2 | 0.0 | 1.1 | 1.1 | -0.9 | 0.9 | 1.1 |
| Mean time between licks in bursts | 0.5 | 0.7 | 1.1 | 0.7 | -0.9 | -0.9 | -1.0 | 0.0 | -1.0 | -0.9 | 0.9 | -0.9 | -0.9 |
| Social responses | 0.5 | 0.6 | 1.0 | 0.9 | -0.8 | -0.6 | -1.0 | 0.0 | -1.0 | -0.7 | 0.7 | -0.8 | -0.8 |
| Intermittent access standard deviation | 0.5 | 0.5 | 1.8 | 0.5 | -0.6 | -1.3 | -0.3 | 0.0 | -0.6 | -0.7 | 0.9 | -0.8 | -0.6 |
| One hour access (0.3 mA shock) | 0.5 | 0.6 | 0.7 | -0.8 | 0.8 | 0.7 | 0.9 | 0.0 | 0.8 | 0.8 | -0.7 | 0.8 | 0.8 |
| Total zone transitions, hab. session 1 | 0.5 | 0.7 | 1.0 | 0.9 | -0.9 | -0.7 | -1.0 | 0.0 | -1.0 | -0.9 | 0.8 | -0.9 | -0.9 |
| Total zone transitions, NPP test | 0.5 | 0.7 | 1.2 | -0.7 | 1.0 | -0.0 | 0.9 | 0.0 | 1.0 | 1.1 | -0.8 | 0.8 | 1.0 |
| Cd content in liver | 0.5 | 0.6 | 1.0 | -0.7 | 0.9 | 0.5 | 0.7 | 0.0 | 0.7 | 1.0 | -0.9 | 0.9 | 0.9 |
| Social response proportion | 0.4 | 0.5 | 1.2 | 0.4 | -0.7 | -0.8 | -1.1 | 0.0 | -1.0 | -0.6 | 0.6 | -0.6 | -0.6 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.4 | 0.6 | -0.5 | 0.7 | 0.6 | 0.7 | 0.0 | 0.7 | 0.8 | -0.7 | 0.7 | 0.7 |
| Cocaine induced anxiety | 0.4 | 0.4 | 1.1 | -0.4 | 0.6 | 1.0 | 0.5 | 0.0 | 0.7 | 0.7 | -0.7 | 0.7 | 0.6 |
| Short access day 1 locomotion | 0.4 | 0.4 | 0.6 | 0.6 | -0.6 | -0.7 | -0.8 | 0.0 | -0.7 | -0.6 | 0.7 | -0.7 | -0.6 |
| Locomotion distance, session 8 | 0.4 | 0.6 | 0.8 | -0.7 | 0.8 | 0.7 | 0.9 | 0.0 | 0.9 | 0.8 | -0.8 | 0.8 | 0.8 |
| Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 0.8 | -0.9 | 0.7 | 0.4 | 0.8 | 0.0 | 0.8 | 0.6 | -0.6 | 0.6 | 0.7 |
| Bone: minimum diameter | 0.4 | 0.8 | 2.2 | -0.6 | 0.8 | 1.5 | 0.9 | 0.0 | 0.9 | 0.8 | -1.0 | 0.9 | 0.7 |
| Delta distance traveled before/after self-admin | 0.4 | 0.4 | 0.9 | -0.6 | 0.6 | 1.0 | 0.8 | 0.0 | 0.6 | 0.6 | -0.7 | 0.7 | 0.5 |
| Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 0.7 | 0.8 | -0.6 | -0.9 | -0.8 | 0.0 | -0.6 | -0.5 | 0.6 | -0.6 | -0.6 |
| Delay disc. indifference point, 8s delay | 0.4 | 0.4 | 0.5 | 0.7 | -0.6 | -0.7 | -0.7 | 0.0 | -0.7 | -0.6 | 0.7 | -0.7 | -0.6 |
| Rest time, locomotor task time 1 | 0.4 | 0.4 | 0.6 | 0.8 | -0.6 | -0.7 | -0.6 | 0.0 | -0.7 | -0.6 | 0.6 | -0.7 | -0.7 |
| Intraocular pressure | 0.3 | 0.5 | 1.1 | 0.8 | -0.6 | -0.4 | -1.0 | 0.0 | -0.8 | -0.6 | 0.6 | -0.6 | -0.7 |
| Indifference point function ln k | 0.3 | 0.4 | 0.5 | -0.5 | 0.6 | 0.7 | 0.7 | 0.0 | 0.4 | 0.7 | -0.7 | 0.7 | 0.6 |
| Indifference point function log k | 0.3 | 0.4 | 0.5 | -0.5 | 0.6 | 0.7 | 0.7 | 0.0 | 0.4 | 0.7 | -0.7 | 0.7 | 0.6 |
| Cocaine response after cond. not corrected | 0.3 | 0.3 | 1.4 | 0.4 | -0.5 | -1.2 | -0.4 | 0.0 | -0.4 | -0.5 | 0.7 | -0.6 | -0.4 |
| Condit. Reinf. active minus inactive responses | 0.3 | 0.4 | 0.8 | -0.5 | 0.8 | 0.4 | 0.6 | 0.0 | 0.6 | 0.9 | -0.7 | 0.7 | 0.8 |
| Conditioned reinforcement - inactives | 0.3 | 0.4 | 0.7 | -0.5 | 0.8 | 0.2 | 0.7 | 0.0 | 0.6 | 0.8 | -0.6 | 0.6 | 0.8 |
| Post-drug Anxiety | 0.3 | 0.4 | 0.5 | -0.4 | 0.6 | 0.7 | 0.5 | 0.0 | 0.7 | 0.7 | -0.7 | 0.7 | 0.6 |
| Locomotion velocity, session 2 | 0.3 | 0.4 | 1.2 | 0.8 | -0.4 | -1.1 | -0.5 | 0.0 | -0.6 | -0.4 | 0.6 | -0.6 | -0.5 |
| Locomotion velocity, hab. session 1 | 0.3 | 0.4 | 0.7 | -0.6 | 0.6 | 0.8 | 0.5 | 0.0 | 0.5 | 0.7 | -0.7 | 0.7 | 0.6 |
| Locomotion velocity, hab. session 2 | 0.3 | 0.4 | 0.6 | -0.4 | 0.7 | 0.6 | 0.8 | 0.0 | 0.8 | 0.8 | -0.7 | 0.7 | 0.7 |
| Time in novel zone, NPP test | 0.3 | 0.3 | 0.6 | 0.8 | -0.6 | -0.4 | -0.6 | 0.0 | -0.5 | -0.6 | 0.6 | -0.7 | -0.7 |
| Total locomotion distance, NPP test | 0.3 | 0.4 | 0.7 | -0.6 | 0.8 | 0.2 | 0.7 | 0.0 | 0.7 | 0.9 | -0.7 | 0.7 | 0.8 |
| Bone: connectivity density | 0.3 | 0.5 | 0.7 | -0.7 | 0.8 | 0.8 | 0.8 | 0.0 | 0.8 | 0.8 | -0.8 | 0.8 | 0.8 |
| Bone: periosteal estimation | 0.3 | 0.7 | 1.5 | 1.2 | -1.0 | 0.2 | -0.8 | 0.0 | -0.8 | -0.9 | 0.7 | -0.8 | -1.0 |
| Bone: tissue strength | 0.3 | 0.3 | 0.5 | 0.5 | -0.6 | -0.0 | -0.7 | 0.0 | -0.7 | -0.6 | 0.5 | -0.5 | -0.6 |
| Bone: trabecular number | 0.3 | 0.4 | 0.5 | -0.5 | 0.7 | 0.7 | 0.7 | 0.0 | 0.7 | 0.7 | -0.7 | 0.7 | 0.6 |
| Time to tail flick, test, before self-admin | 0.3 | 0.3 | 1.8 | 1.3 | -0.3 | 0.2 | -0.3 | 0.0 | -0.4 | -0.3 | 0.3 | -0.3 | -0.3 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.4 | 0.5 | -0.6 | 0.7 | 0.6 | 0.4 | 0.0 | 0.7 | 0.7 | -0.6 | 0.7 | 0.7 |
| Distance moved, locomotor task time 2 | 0.3 | 0.4 | 0.6 | 0.7 | -0.7 | -0.4 | -0.8 | 0.0 | -0.6 | -0.7 | 0.7 | -0.7 | -0.7 |
| Seeking ratio, delayed vs. immediate footshock | 0.3 | 0.4 | 0.6 | -0.5 | 0.6 | 0.8 | 0.7 | 0.0 | 0.6 | 0.7 | -0.7 | 0.6 | 0.6 |
| Latency to leave start box in cocaine runway, F | 0.3 | 0.3 | 0.6 | 0.5 | -0.6 | -0.8 | -0.4 | 0.0 | -0.5 | -0.6 | 0.6 | -0.6 | -0.6 |
| Heart weight | 0.2 | 0.2 | 0.6 | 0.6 | -0.5 | 0.3 | -0.8 | 0.0 | -0.3 | -0.5 | 0.4 | -0.4 | -0.6 |
| Times rat made contact with spout | 0.2 | 0.2 | 0.4 | -0.4 | 0.6 | -0.1 | 0.6 | 0.0 | 0.6 | 0.6 | -0.4 | 0.4 | 0.6 |
| Reaction time premature initiation rate | 0.2 | 0.3 | 1.0 | -0.3 | 0.4 | 1.0 | 0.6 | 0.0 | 0.4 | 0.4 | -0.5 | 0.5 | 0.4 |
| Condit. Reinf. inactive responses | 0.2 | 0.3 | 0.8 | 0.5 | -0.5 | -0.9 | -0.6 | 0.0 | -0.6 | -0.4 | 0.6 | -0.6 | -0.4 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 0.5 | 0.4 | -0.3 | -0.7 | -0.5 | 0.0 | -0.4 | -0.3 | 0.3 | -0.3 | -0.3 |
| Short access day 10 total infusions | 0.2 | 0.2 | 0.6 | 0.5 | -0.5 | -0.8 | -0.1 | 0.0 | -0.6 | -0.5 | 0.5 | -0.5 | -0.5 |
| Locomotion velocity, session 1 | 0.2 | 0.2 | 0.4 | -0.3 | 0.6 | -0.1 | 0.3 | 0.0 | 0.5 | 0.6 | -0.4 | 0.4 | 0.5 |
| Locomotion distance, session 1 | 0.2 | 0.2 | 0.9 | 0.5 | -0.4 | -1.0 | -0.4 | 0.0 | -0.3 | -0.4 | 0.5 | -0.5 | -0.4 |
| Degree of sensitization distance | 0.2 | 0.2 | 0.4 | 0.2 | -0.6 | -0.4 | -0.6 | 0.0 | -0.6 | -0.6 | 0.5 | -0.5 | -0.5 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.3 | 0.5 | -0.5 | -0.5 | -0.5 | 0.0 | -0.5 | -0.5 | 0.6 | -0.6 | -0.5 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.6 | -0.7 | 0.6 | -0.0 | 0.5 | 0.0 | 0.5 | 0.5 | -0.4 | 0.5 | 0.6 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.4 | -0.2 | 0.6 | 0.2 | 0.6 | 0.0 | 0.6 | 0.6 | -0.5 | 0.5 | 0.5 |
| Locomotion velocity, NPP test | 0.2 | 0.2 | 0.4 | -0.4 | 0.6 | 0.2 | 0.5 | 0.0 | 0.5 | 0.6 | -0.5 | 0.5 | 0.6 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.7 | 0.3 | -0.5 | -0.8 | -0.6 | 0.0 | -0.5 | -0.6 | 0.6 | -0.6 | -0.5 |
| Bone surface | 0.2 | 0.4 | 0.8 | 0.9 | -0.7 | -0.3 | -0.6 | 0.0 | -0.6 | -0.7 | 0.6 | -0.6 | -0.7 |
| Bone volume | 0.2 | 0.3 | 0.5 | 0.7 | -0.6 | -0.2 | -0.5 | 0.0 | -0.5 | -0.6 | 0.5 | -0.5 | -0.6 |
| Bone: cortical area | 0.2 | 0.3 | 1.5 | -0.2 | 0.3 | 1.2 | 0.6 | 0.0 | 0.6 | 0.3 | -0.5 | 0.5 | 0.2 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.5 | -0.4 | 0.4 | 0.7 | 0.4 | 0.0 | 0.4 | 0.4 | -0.5 | 0.5 | 0.4 |
| Bone: cortical porosity | 0.2 | 0.2 | 0.3 | -0.5 | 0.4 | 0.6 | 0.4 | 0.0 | 0.4 | 0.4 | -0.5 | 0.5 | 0.4 |
| Bone: endosteal perimeter | 0.2 | 0.4 | 0.9 | 0.9 | -0.7 | -0.2 | -0.5 | 0.0 | -0.5 | -0.7 | 0.6 | -0.6 | -0.8 |
| Bone: final force | 0.2 | 0.3 | 0.5 | 0.7 | -0.6 | 0.7 | -0.6 | 0.0 | -0.4 | -0.6 | 0.3 | -0.4 | -0.7 |
| Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 0.3 | 0.0 | -0.5 | -0.4 | -0.4 | 0.0 | -0.4 | -0.6 | 0.5 | -0.5 | -0.5 |
| Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.8 | -0.3 | 0.3 | 0.9 | 0.5 | 0.0 | 0.5 | 0.3 | -0.4 | 0.4 | 0.3 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 0.4 | 0.2 | -0.5 | -0.3 | -0.5 | 0.0 | -0.4 | -0.6 | 0.6 | -0.6 | -0.5 |
| Locomotion in novel chamber post-restriction | 0.2 | 0.2 | 0.4 | 0.6 | -0.5 | -0.5 | -0.7 | 0.0 | -0.4 | -0.4 | 0.4 | -0.4 | -0.5 |
| Rb content in liver | 0.2 | 0.3 | 0.5 | -0.2 | 0.6 | 0.5 | 0.6 | 0.0 | 0.6 | 0.7 | -0.6 | 0.6 | 0.6 |
| Parametrial fat weight | 0.1 | 0.2 | 0.4 | 0.5 | -0.4 | -0.6 | -0.5 | 0.0 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 |
| Tibia length | 0.1 | 0.2 | 0.4 | -0.7 | 0.5 | 0.5 | 0.3 | 0.0 | 0.2 | 0.5 | -0.5 | 0.5 | 0.6 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.4 | -0.1 | 0.3 | 0.6 | 0.4 | 0.0 | 0.4 | 0.3 | -0.3 | 0.3 | 0.2 |
| Locomotor activity | 0.1 | 0.2 | 0.3 | -0.5 | 0.4 | 0.6 | -0.0 | 0.0 | 0.3 | 0.4 | -0.4 | 0.4 | 0.4 |
| Locomotor testing distance | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | 0.5 | -0.1 | 0.0 | 0.2 | 0.4 | -0.3 | 0.3 | 0.3 |
| Reaction time false alarm rate | 0.1 | 0.1 | 0.3 | -0.5 | 0.4 | 0.2 | 0.3 | 0.0 | 0.3 | 0.4 | -0.4 | 0.4 | 0.4 |
| Saline control response | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 | 0.5 | 0.0 | 0.4 | 0.3 | -0.2 | 0.2 | 0.2 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.2 | -0.3 | 0.4 | 0.3 | 0.2 | 0.0 | 0.2 | 0.4 | -0.4 | 0.4 | 0.4 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.3 | 0.3 | -0.5 | -0.1 | -0.3 | 0.0 | -0.3 | -0.5 | 0.4 | -0.4 | -0.5 |
| Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | 0.1 | 0.4 | 0.0 | 0.3 | 0.3 | -0.2 | 0.2 | 0.3 |
| Intermittent access total infusions | 0.1 | 0.1 | 0.3 | 0.3 | -0.2 | -0.5 | -0.1 | 0.0 | -0.3 | -0.3 | 0.3 | -0.3 | -0.2 |
| Intermittent access day 15 total locomotion | 0.1 | 0.1 | 0.5 | 0.1 | -0.1 | -0.7 | -0.2 | 0.0 | -0.2 | -0.1 | 0.2 | -0.2 | -0.1 |
| Lifetime Intake | 0.1 | 0.1 | 0.4 | 0.4 | -0.3 | -0.6 | -0.2 | 0.0 | -0.4 | -0.3 | 0.4 | -0.4 | -0.3 |
| Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.4 | 0.3 | -0.3 | -0.6 | -0.5 | 0.0 | -0.4 | -0.2 | 0.3 | -0.3 | -0.3 |
| Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.1 | 0.3 | -0.2 | -0.3 | -0.2 | 0.0 | -0.3 | -0.2 | 0.3 | -0.3 | -0.2 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.1 | 0.2 | 0.5 | -0.3 | -0.4 | -0.3 | 0.0 | -0.4 | -0.3 | 0.4 | -0.4 | -0.3 |
| Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.5 | 0.2 | -0.1 | -0.7 | 0.2 | 0.0 | -0.3 | -0.0 | 0.2 | -0.1 | -0.1 |
| Short access day 10 total inactive lever presses | 0.1 | 0.2 | 0.4 | -0.4 | 0.5 | -0.0 | 0.4 | 0.0 | 0.3 | 0.6 | -0.4 | 0.4 | 0.5 |
| One hour access (shock baseline) | 0.1 | 0.1 | 0.2 | 0.5 | -0.3 | -0.2 | 0.0 | 0.0 | -0.3 | -0.3 | 0.3 | -0.4 | -0.4 |
| Locomotion velocity, session 3 | 0.1 | 0.1 | 0.4 | 0.6 | -0.0 | -0.2 | 0.2 | 0.0 | 0.2 | -0.0 | 0.2 | -0.2 | -0.2 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.1 | -0.1 | 0.2 | 0.2 | 0.3 | 0.0 | 0.4 | 0.3 | -0.3 | 0.3 | 0.2 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.1 | -0.3 | 0.3 | -0.1 | 0.2 | 0.0 | 0.4 | 0.3 | -0.2 | 0.2 | 0.3 |
| Total zone transitions, hab. session 2 | 0.1 | 0.2 | 0.6 | 0.5 | -0.3 | -0.8 | -0.3 | 0.0 | -0.3 | -0.3 | 0.5 | -0.5 | -0.3 |
| Bone: final moment | 0.1 | 0.2 | 0.8 | 0.5 | -0.4 | 0.9 | -0.3 | 0.0 | -0.2 | -0.4 | 0.1 | -0.2 | -0.5 |
| Bone: maximum diameter | 0.1 | 0.3 | 0.6 | 0.8 | -0.6 | 0.0 | -0.4 | 0.0 | -0.3 | -0.6 | 0.5 | -0.5 | -0.7 |
| Bone: maximum force | 0.1 | 0.1 | 0.7 | 0.3 | -0.2 | 0.8 | -0.2 | 0.0 | -0.1 | -0.2 | -0.0 | -0.0 | -0.3 |
| Bone: maximum moment | 0.1 | 0.1 | 1.0 | 0.0 | -0.0 | 1.0 | 0.0 | 0.0 | 0.1 | -0.0 | -0.2 | 0.2 | -0.1 |
| Bone: trabecular thickness | 0.1 | 0.1 | 0.1 | -0.3 | 0.3 | -0.1 | 0.2 | 0.0 | 0.2 | 0.3 | -0.2 | 0.3 | 0.3 |
| Distance traveled after self-admin | 0.1 | 0.1 | 0.3 | -0.6 | 0.3 | 0.5 | 0.1 | 0.0 | 0.2 | 0.3 | -0.3 | 0.3 | 0.2 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.4 | -0.7 | 0.3 | -0.3 | 0.4 | 0.0 | 0.3 | 0.3 | -0.3 | 0.3 | 0.3 |
| Ambulatory time after self-admin | 0.1 | 0.1 | 0.2 | 0.1 | -0.4 | -0.4 | -0.4 | 0.0 | -0.4 | -0.4 | 0.4 | -0.4 | -0.4 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.2 | 0.1 | -0.3 | -0.1 | -0.4 | 0.0 | -0.3 | -0.2 | 0.2 | -0.2 | -0.2 |
| Bouts of movement, locomotor time 2 | 0.1 | 0.1 | 0.4 | 0.6 | -0.2 | 0.5 | -0.5 | 0.0 | -0.2 | -0.1 | -0.1 | 0.0 | -0.2 |
| Total resting periods, locomotor time 2 | 0.1 | 0.1 | 0.5 | 0.7 | -0.3 | 0.2 | -0.6 | 0.0 | -0.4 | -0.2 | 0.1 | -0.2 | -0.3 |
| Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.3 | -0.1 | 0.2 | 0.6 | 0.0 | 0.0 | 0.3 | 0.2 | -0.2 | 0.2 | 0.2 |
| Weight adjusted by age | 0.1 | 0.2 | 0.3 | -0.2 | 0.5 | 0.6 | 0.1 | 0.0 | 0.3 | 0.5 | -0.4 | 0.4 | 0.5 |
| Mg content in liver | 0.1 | 0.1 | 0.4 | -0.6 | 0.4 | -0.1 | 0.3 | 0.0 | 0.3 | 0.4 | -0.4 | 0.4 | 0.5 |
| Mn content in liver | 0.1 | 0.2 | 0.5 | -0.5 | 0.3 | 0.7 | 0.2 | 0.0 | 0.3 | 0.3 | -0.5 | 0.5 | 0.3 |
| Sr content in liver | 0.1 | 0.0 | 0.3 | 0.5 | -0.1 | -0.3 | -0.0 | 0.0 | -0.1 | 0.0 | 0.2 | -0.2 | -0.2 |
| Glucose | 0.0 | 0.1 | 0.5 | 0.2 | -0.0 | 0.7 | -0.1 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.0 |
| Retroperitoneal fat weight | 0.0 | 0.1 | 0.4 | 0.3 | -0.3 | -0.6 | -0.4 | 0.0 | -0.3 | -0.4 | 0.4 | -0.4 | -0.3 |
| Light reinforcement 1 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.1 | 0.2 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 |
| Reaction time mean minus median | 0.0 | 0.0 | 0.2 | 0.1 | -0.2 | -0.3 | -0.4 | 0.0 | -0.2 | -0.2 | 0.2 | -0.2 | -0.2 |
| Reaction time mean minus median AUC | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | -0.4 | 0.0 | -0.2 | -0.1 | 0.1 | -0.1 | -0.1 |
| Social time | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.0 | -0.4 | 0.0 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 |
| Cocaine response after cond. corrected | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.4 | 0.2 | 0.0 | 0.2 | -0.0 | 0.1 | -0.1 | 0.1 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.3 | -0.1 | 0.0 | -0.2 | 0.2 | -0.0 | 0.0 | 0.1 |
| Condit. Reinf. lever reinforcers received | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | 0.0 | -0.1 | 0.2 | -0.1 | 0.1 | 0.1 |
| Conditioned locomotion | 0.0 | 0.0 | 0.1 | 0.0 | -0.1 | -0.2 | -0.3 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
| Intermitt. access escalation Index | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | -0.0 | 0.3 | 0.0 | 0.1 | 0.2 | -0.1 | 0.1 | 0.1 |
| Intermittent access day 1 locomotion | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.1 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
| Intermittent access total locomotion | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | -0.2 | 0.2 | 0.0 | 0.2 | 0.2 | -0.1 | 0.1 | 0.2 |
| Progressive ratio test 2 active lever presses | 0.0 | 0.1 | 0.2 | 0.2 | -0.1 | -0.5 | -0.2 | 0.0 | -0.3 | -0.1 | 0.2 | -0.2 | -0.1 |
| Progressive ratio test 2 breakpoint | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.4 | -0.1 | 0.0 | -0.2 | 0.0 | 0.1 | -0.1 | -0.0 |
| Progressive ratio test 2 inactive lever presses | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.4 | 0.2 | 0.0 | -0.1 | 0.2 | -0.1 | 0.1 | 0.1 |
| Total sessions with >9 infusions | 0.0 | 0.1 | 0.3 | 0.2 | -0.1 | -0.5 | 0.1 | 0.0 | -0.3 | -0.1 | 0.2 | -0.2 | -0.1 |
| Short access day 1 total infusions | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | -0.3 | 0.1 | 0.0 | -0.2 | 0.1 | -0.0 | 0.0 | -0.0 |
| Short access day 10 total locomotion | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | -0.1 | 0.0 | 0.0 | -0.0 | 0.0 | 0.1 | -0.1 | 0.1 |
| Short access total locomotion | 0.0 | 0.0 | 0.3 | 0.2 | -0.1 | -0.6 | -0.2 | 0.0 | -0.2 | -0.0 | 0.2 | -0.1 | -0.0 |
| Locomotion distance, session 3 | 0.0 | 0.1 | 0.3 | 0.6 | -0.1 | -0.2 | -0.1 | 0.0 | -0.1 | -0.1 | 0.2 | -0.2 | -0.2 |
| Stereotopy head waving bouts, day 3 | 0.0 | 0.1 | 0.1 | -0.1 | 0.2 | 0.1 | 0.3 | 0.0 | 0.4 | 0.2 | -0.3 | 0.2 | 0.2 |
| Locomotion velocity, session 7 | 0.0 | 0.0 | 0.2 | -0.3 | 0.1 | 0.4 | 0.2 | 0.0 | 0.2 | 0.0 | -0.2 | 0.2 | 0.1 |
| Incentive salience index mean | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.3 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.2 |
| Time in familiar zone, hab. session 1 | 0.0 | 0.0 | 0.2 | 0.2 | -0.1 | 0.5 | 0.2 | 0.0 | 0.1 | -0.2 | 0.1 | -0.1 | -0.2 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.3 | -0.1 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 |
| Pavlov. Cond. lever latency | 0.0 | 0.1 | 0.5 | 0.1 | 0.0 | 0.7 | 0.2 | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | -0.0 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.1 | 0.2 | -0.2 | -0.3 | 0.4 | -0.2 | 0.0 | -0.1 | -0.4 | 0.1 | -0.1 | -0.2 |
| Pavlov. Cond. change in total contacts | 0.0 | 0.0 | 0.1 | -0.3 | 0.1 | -0.0 | -0.0 | 0.0 | 0.3 | 0.1 | -0.1 | 0.1 | 0.1 |
| Pavlov. Cond. index score | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | 0.0 | -0.1 | -0.3 | 0.2 | -0.2 | -0.1 |
| Pavlov. Cond. latency score | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.2 | -0.2 | 0.0 | -0.1 | -0.2 | 0.2 | -0.1 | -0.1 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | -0.2 | -0.0 | 0.0 | -0.0 | 0.2 | -0.0 | -0.0 | 0.0 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.1 | -0.2 | 0.0 | -0.0 | -0.3 | 0.2 | -0.1 | -0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.0 | 0.2 | -0.4 | 0.0 | -0.1 | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | 0.0 | 0.1 |
| Bone: apparent density | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | 0.3 | 0.2 | 0.0 | 0.3 | 0.2 | -0.2 | 0.2 | 0.2 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.2 | 0.2 | -0.2 | 0.4 | -0.3 | 0.0 | -0.2 | -0.1 | 0.1 | -0.1 | -0.2 |
| Bone: periosteal perimeter | 0.0 | 0.0 | 0.2 | 0.3 | -0.2 | 0.4 | -0.0 | 0.0 | -0.0 | -0.2 | 0.1 | -0.1 | -0.2 |
| Bone: trabecular spacing | 0.0 | 0.1 | 0.1 | 0.1 | -0.3 | -0.1 | -0.3 | 0.0 | -0.3 | -0.3 | 0.2 | -0.2 | -0.3 |
| Bone: trabecular tissue density | 0.0 | 0.0 | 0.0 | -0.1 | -0.0 | 0.0 | 0.1 | 0.0 | 0.0 | -0.1 | -0.0 | 0.0 | -0.0 |
| Breakpoint value in progressive ratio session | 0.0 | 0.0 | 0.1 | -0.2 | 0.0 | 0.2 | 0.2 | 0.0 | 0.1 | -0.0 | -0.0 | 0.0 | 0.0 |
| Extinction: sum of active levers before priming | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | 0.4 | -0.0 | 0.0 | -0.0 | -0.2 | 0.1 | -0.1 | -0.1 |
| Rest time, locomotor task time 2 | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | -0.2 | -0.3 | 0.0 | -0.3 | -0.1 | 0.2 | -0.2 | -0.2 |
| Food seeking constrained by brief footshock | 0.0 | 0.0 | 0.2 | 0.2 | 0.1 | 0.5 | 0.2 | 0.0 | 0.1 | 0.1 | -0.2 | 0.1 | 0.0 |
| Run reversals in cocaine runway, males | 0.0 | 0.0 | 0.1 | 0.3 | -0.1 | -0.3 | -0.3 | 0.0 | -0.3 | -0.1 | 0.1 | -0.1 | -0.1 |
| Na content in liver | 0.0 | 0.0 | 0.0 | -0.2 | -0.0 | -0.2 | 0.0 | 0.0 | -0.0 | -0.1 | 0.1 | -0.1 | 0.0 |
| Se content in liver | 0.0 | 0.0 | 0.3 | 0.0 | -0.0 | -0.5 | -0.1 | 0.0 | -0.1 | -0.0 | 0.1 | -0.1 | -0.0 |
| Zn content in liver | 0.0 | 0.0 | 0.1 | 0.3 | -0.1 | -0.1 | -0.2 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.