Best TWAS P=1.69e-10 · Best GWAS P=1.59e-10 conditioned to 6.28e-02
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint | 
|---|---|---|---|---|---|---|---|---|---|---|---|
| Brain | Ralyl | alternative TSS | XM_008760853.3 | 0.07 | 7 | 0.02 | 2.9e-03 | 5.2 | 2.00e-07 | 0.22 | FALSE | 
| Brain | Ralyl | intron excision ratio | chr2_87631467_87663759 | 0.05 | 1 | 0.01 | 2.9e-02 | 5.32 | 1.06e-07 | 0.03 | FALSE | 
| IL | Ralyl | alternative TSS | XM_039101954.1 | 0.19 | 192 | 0.04 | 5.0e-02 | 5.5 | 3.82e-08 | 0.31 | FALSE | 
| IL | Ralyl | alternative TSS | XM_039101954.1 | 0.19 | 207 | 0.03 | 5.7e-02 | 5.5 | 3.78e-08 | 0.32 | FALSE | 
| IL | Ralyl | isoform ratio | XM_039101954.1 | 0.28 | 103 | 0.11 | 1.2e-03 | 6.1 | 1.06e-09 | 0.6 | FALSE | 
| LHb | Ralyl | alternative TSS | NM_001024978.2 | 0.64 | 1 | 0.19 | 2.9e-05 | -6.11 | 9.74e-10 | 0.19 | FALSE | 
| LHb | Ralyl | alternative TSS | XM_039101954.1 | 0.34 | 4 | 0.06 | 1.4e-02 | -6.16 | 7.14e-10 | 0.55 | FALSE | 
| LHb | Ralyl | alternative TSS | NM_001024978.2 | 0.74 | 5 | 0.19 | 2.3e-05 | 6.23 | 4.75e-10 | 0.77 | FALSE | 
| LHb | Ralyl | alternative TSS | XM_008760853.3 | 0.33 | 1 | 0.07 | 8.9e-03 | 5.57 | 2.50e-08 | 0.05 | FALSE | 
| LHb | Ralyl | alternative TSS | XM_039101954.1 | 0.34 | 4 | 0.06 | 1.3e-02 | -6.13 | 9.01e-10 | 0.54 | FALSE | 
| LHb | Ralyl | gene expression | Ralyl | 0.67 | 1 | 0.07 | 9.7e-03 | -5.58 | 2.44e-08 | 0.05 | FALSE | 
| LHb | Ralyl | isoform ratio | NM_001393770.1 | 0.3 | 1 | 0.05 | 2.2e-02 | -5.6 | 2.19e-08 | 0.05 | FALSE | 
| LHb | Ralyl | isoform ratio | XM_008760853.3 | 0.29 | 4 | 0.07 | 7.9e-03 | 6.23 | 4.52e-10 | 0.46 | FALSE | 
| LHb | Ralyl | isoform ratio | XM_039101954.1 | 0.39 | 111 | 0.12 | 8.0e-04 | 5.89 | 3.97e-09 | 0.48 | FALSE | 
| NAcc | Ralyl | intron excision ratio | chr2_87483682_87539067 | 0.05 | 2646 | 0.02 | 1.4e-03 | -5.52 | 3.41e-08 | 0.29 | FALSE | 
| OFC | Ralyl | alternative TSS | XM_008760853.3 | 0.26 | 1 | 0.04 | 3.7e-02 | -6.39 | 1.69e-10 | 0.09 | TRUE | 
| OFC | Ralyl | intron excision ratio | chr2_87663834_87750876 | 0.18 | 1 | 0.09 | 3.5e-03 | -5.57 | 2.50e-08 | 0.05 | FALSE | 
| pVTA | Ralyl | alternative TSS | XM_017590727.2 | 0.19 | 58 | 0.14 | 1.3e-06 | 5.37 | 7.70e-08 | 0.31 | FALSE | 
| pVTA | Ralyl | alternative TSS | XM_017590727.2 | 0.19 | 58 | 0.14 | 7.8e-07 | 5.45 | 5.14e-08 | 0.35 | FALSE |