Hub : Genes

Eif4e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000052343	0.11	0.06	1.1e-03	0.04	0.04	0.03	0.04	4.6e-03	5.4e-03	9.9e-03	2.9e-03
2	Brain	gene expression	ENSRNOG00000052343	0.07	0.04	2.3e-04	0.02	0.02	0.01	0.02	4.1e-03	3.6e-03	1.5e-02	5.2e-03
3	Brain	isoform ratio	ENSRNOT00000102814	0.05	0.03	6.2e-03	0	0.02	0.01	0.01	3.0e-01	9.7e-03	1.7e-02	2.1e-02
4	OFC	intron excision ratio	chr2:227089221:227091861	0.22	0.11	3.0e-03	0.1	0.03	0.05	0.09	2.9e-03	6.0e-02	3.0e-02	4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	2.7	8.7	16.5	4.1	2.8	1.7	-2.7
BMI without tail	3.2	6.7	17.4	4.2	2.7	0.5	-1.3
Body weight	2.4	10.3	26.9	5.2	2.9	0.9	-2.2
Epididymis fat weight	0.2	0.5	1.6	1.3	0.6	0.1	-0.3
Glucose	0.6	0.9	2.0	0.8	0.8	0.4	-1.4
Heart weight	0.2	0.3	1.1	0.2	-0.1	-1.1	0.2
Left kidney weight	1.1	3.2	6.7	2.6	1.0	1.0	-2.0
Right kidney weight	1.2	3.4	8.9	3.0	1.6	0.5	-1.4
Tail length	0.2	0.6	1.8	1.4	0.6	-0.5	0.3
Length with tail	0.5	1.7	4.6	2.1	1.3	-0.5	-0.4
Length without tail	0.6	1.3	2.6	1.3	1.6	0.2	-1.1
Liver weight, left	0.2	0.4	0.9	0.0	0.9	0.4	0.6
Liver weight, right	0.9	1.4	4.4	0.8	2.1	0.8	-0.2
Parametrial fat weight	0.5	1.0	2.8	0.9	1.7	0.4	0.3
Retroperitoneal fat weight	0.7	2.3	4.9	2.2	1.8	0.4	-1.0
Intraocular pressure	0.9	1.3	2.9	-0.1	0.2	-1.5	1.7
Extensor digitorum longus weight	2.4	9.5	26.7	5.2	2.4	-2.3	-0.5
Soleus weight	0.3	1.0	2.3	1.5	0.2	-1.3	0.3
Tibialis anterior weight	3.0	10.5	29.2	5.4	2.5	-2.2	-1.2
Tibia length	0.7	1.9	3.8	1.9	1.5	-1.2	-0.4
Number of licking bursts	1.8	2.2	4.4	0.7	1.4	2.1	-1.3
Food consumed during 24 hour testing period	0.7	0.8	1.6	1.3	0.1	0.5	-1.2
Times rat made contact with spout	1.0	1.2	2.7	0.6	0.8	1.0	-1.6
Mean time between licks in bursts	0.3	0.5	0.9	-0.1	0.6	0.9	-0.8
Mean num. licks in bursts	0.5	0.6	1.9	-0.2	-0.7	-1.4	0.1
Std. dev. time between licks in bursts	1.5	1.8	4.4	-1.0	-0.8	2.1	-1.1
Water consumed over 24 hours	0.6	0.7	1.6	1.3	0.6	0.4	-0.8
Indifference point 0 sec	0.6	1.0	2.0	-1.1	-0.8	1.4	-0.1
Indifference point AUC	1.2	1.4	2.4	1.4	1.6	0.7	-0.9
Indifference point function ln k	0.5	0.7	1.5	-0.8	-1.2	0.7	-0.4
Indifference point function log k	0.5	0.7	1.5	-0.8	-1.2	0.7	-0.4
Delay discounting total patch changes 0 sec	0.6	1.0	2.4	-0.9	-0.7	1.5	-0.2
Delay discounting total patch changes 12 sec	0.7	1.0	1.9	0.5	0.5	1.4	-1.2
Delay discounting total patch changes 18 sec	1.0	1.4	4.3	0.3	0.4	2.1	-1.0
Delay discounting total patch changes 24 sec	0.2	0.2	0.8	0.3	-0.1	0.9	-0.0
Delay discounting total patch changes 6 sec	2.9	4.4	9.0	1.2	1.7	3.0	-2.1
Delay discounting time to switch 0 sec	0.6	0.9	1.3	-0.6	-0.8	-1.2	1.2
Delay discounting water rate 0 sec	0.8	1.2	1.5	1.0	1.2	1.1	-1.1
Delay discounting water rate 12 sec	0.8	1.1	2.6	1.6	0.7	0.6	-1.0
Delay discounting water rate 18 sec	3.3	4.3	6.1	2.1	2.5	1.5	-2.1
Delay discounting water rate 24 sec	1.9	2.6	3.2	1.4	1.4	1.8	-1.7
Delay discounting water rate 6 sec	2.4	3.5	6.8	1.9	0.7	1.8	-2.6
Locomotor activity	0.2	0.3	0.6	-0.6	-0.1	0.2	-0.8
Locomotor testing distance	0.3	0.4	0.7	-0.7	-0.8	-0.1	-0.7
Locomotor testing rearing	2.5	3.9	9.4	0.1	0.1	2.5	-3.1
Light reinforcement 1	0.6	1.1	1.7	1.0	-0.1	1.2	-1.3
Light reinforcement 2	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2
Reaction time number correct	0.1	0.1	0.4	0.1	0.4	-0.2	-0.6
Reaction time mean minus median	1.0	1.3	2.7	-0.6	-0.3	-1.7	1.5
Reaction time mean minus median AUC	0.6	0.7	1.3	-0.6	-0.5	-1.1	1.0
Reaction time num false alarms	2.9	4.0	5.1	-1.6	-2.1	-1.9	2.2
Reaction time num false alarms AUC	2.9	4.0	5.7	-1.3	-1.8	-2.3	2.4
Reaction time trials correct on left	0.1	0.1	0.4	0.1	0.4	-0.2	-0.6
Reaction time trials on left	0.1	0.1	0.3	0.1	0.3	-0.3	-0.5
Reaction time mean	0.7	0.9	2.9	-0.6	-0.4	-1.7	0.5
Reaction time mean AUC	0.8	1.0	3.2	-0.5	-0.6	-1.8	0.5
Median of all reaction times	0.3	0.5	1.8	-0.2	-0.2	-1.3	-0.1
Reaction time omissions	1.8	2.4	5.4	-0.6	-0.2	-2.3	2.0
Reaction time false alarm rate	2.0	2.9	4.8	-1.1	-1.6	-1.7	2.2
Reaction time premature initiation rate	0.2	0.2	0.5	0.7	-0.4	-0.4	0.4
Reaction time premature initiations	0.3	0.4	0.7	0.8	-0.2	-0.9	0.3
Std. dev. reaction times	1.1	1.5	3.1	-0.7	-0.3	-1.8	1.5
Reaction time trials completed	0.1	0.1	0.3	0.1	0.3	-0.3	-0.5
Reaction time trials AUC	0.1	0.1	0.3	0.2	0.5	-0.2	-0.6
Social response proportion	0.7	0.8	1.4	-0.8	-0.3	-1.2	0.9
Social responses	0.6	0.8	1.7	0.7	1.3	0.3	-0.9
Social time	0.4	0.6	1.1	-0.8	0.3	-0.7	1.0
Conditioned locomotion	2.4	2.8	5.4	-1.3	-1.1	-2.3	1.7
Cocaine response after cond. corrected	0.3	0.3	1.0	-0.4	0.1	-1.0	0.1
Cocaine response after cond. not corrected	0.5	0.6	1.3	-0.9	-0.2	-1.2	-0.2
Cocaine response before conditioning	0.2	0.2	0.3	-0.5	-0.6	-0.0	-0.4
Saline control response	2.6	3.5	5.4	-2.1	-2.3	-1.3	1.7
Condit. Reinf. active minus inactive responses	0.9	1.1	3.3	1.0	1.8	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	5.8	1.4	2.4	0.8	-0.7
Condit. Reinf. active responses	0.6	0.8	2.1	1.0	1.4	-0.0	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.1
Condit. Reinf. lever presses	0.4	0.6	0.8	0.7	0.8	0.4	-0.9
Condit. Reinf. lever reinforcers received	0.5	0.7	1.6	1.0	1.3	-0.0	-0.4
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.9	-0.8	-0.9	0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	-0.4	-0.3	-0.5	0.7
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.7	0.7	0.9	-0.5
Pavlov. Cond. index score	0.2	0.3	0.8	0.5	0.9	-0.0	0.2
Pavlov. Cond. latency score	0.1	0.2	0.5	0.2	0.7	0.3	0.2
Pavlov. Cond. lever contacts	1.0	1.4	2.7	1.6	1.3	0.7	-0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.3	-0.3	0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.5	1.1	1.2	0.6	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.6	0.9	-0.0	0.2
Pavlov. Cond. response bias	0.5	0.7	1.9	1.4	0.9	0.0	-0.3
Conditioned reinforcement - actives	0.9	0.9	2.0	-0.6	-1.1	-0.3	1.4
Conditioned reinforcement - inactives	2.0	2.3	3.7	-1.7	-1.9	-0.9	1.2
Conditioned locomotion	0.8	1.0	1.9	-1.0	-0.9	0.6	1.4
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.1	0.3	0.2	0.1
Intermittent access intake escalation	0.1	0.1	0.2	0.3	0.5	0.0	0.1
Intermittent access intake escalation 2	0.8	0.7	1.8	1.0	1.3	0.3	-0.3
Intermitt. access day 1 inactive lever presses	2.4	2.6	5.5	-2.3	-2.2	-0.3	0.0
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.6	-0.9	-1.2	-1.3	0.1
Intermitt. access escalation Index	1.1	1.0	2.4	-0.7	-0.6	-1.5	0.9
Intermittent access day 1 total infusions	0.6	0.7	1.2	1.1	-0.2	0.7	-1.1
Intermittent access day 15 total infusions	0.7	0.8	1.4	1.2	0.5	0.8	-1.0
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.0	1.4	0.5	1.2	-1.1
Intermittent access total infusions	1.4	1.5	2.5	1.6	0.2	1.2	-1.4
Intermittent access day 1 locomotion	0.4	0.4	0.9	1.0	0.4	0.5	-0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.5	0.2	0.7	0.3	0.0
Intermittent access total locomotion	0.8	0.9	1.5	1.2	1.1	0.5	-0.7
Intermittent access standard deviation	1.3	1.3	2.8	1.7	1.3	0.8	-0.5
Cocaine induced anxiety	0.5	0.5	1.5	-1.2	-0.4	0.1	0.7
Post-drug Anxiety	0.2	0.2	0.3	-0.5	0.0	0.4	-0.5
Baseline Anxiety	1.3	1.3	3.4	0.8	0.4	1.0	-1.9
Lifetime Intake	0.6	0.7	1.1	1.0	-0.4	0.9	-0.8
Incentive Sensitization - Responses	0.7	0.6	1.1	0.8	1.1	-0.4	0.8
Incentive Sensitization - Breakpoint	0.7	0.7	1.4	0.9	1.2	-0.5	0.7
Progressive ratio test 1 active lever presses	0.4	0.5	0.7	0.8	-0.7	0.0	-0.8
Progressive ratio test 1 breakpoint	0.4	0.5	0.9	0.9	-0.4	0.2	-0.9
Progressive ratio test 1 inactive lever presses	1.9	2.0	4.4	-1.7	-2.1	-0.7	0.1
Progressive ratio test 2 active lever presses	1.5	1.6	3.9	2.0	1.2	0.2	-0.9
Progressive ratio test 2 breakpoint	1.7	1.9	4.8	2.2	1.2	0.2	-1.2
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.7	0.3	-0.1	-0.9	0.2
Total sessions with >9 infusions	1.0	1.1	4.1	-0.0	-2.0	0.1	0.5
Short access day 1 total inactive lever presses	0.8	0.9	1.8	-1.0	-1.3	0.8	-0.6
Short access day 10 total inactive lever presses	3.2	3.6	8.5	-2.9	-2.1	-0.7	0.9
Short access day 1 total infusions	0.8	0.9	1.9	-0.8	-1.4	0.7	0.7
Short access day 10 total infusions	0.9	1.0	3.1	-0.6	-1.8	0.4	-0.4
Short access total infusions	0.5	0.6	1.9	0.1	-1.4	0.5	-0.1
Short access day 1 locomotion	0.8	0.9	3.0	-0.3	-0.6	1.7	0.1
Short access day 10 total locomotion	0.4	0.5	1.4	0.2	0.3	1.2	-0.5
Short access total locomotion	0.3	0.3	1.2	-0.2	-0.2	1.1	-0.2
Compulsive drug intake	0.1	0.1	0.3	-0.0	0.6	-0.2	-0.3
One hour access (0.3 mA shock)	1.4	1.6	2.8	1.7	1.4	0.9	-1.0
One hour access (shock baseline)	0.4	0.5	0.6	0.8	0.2	0.8	-0.8
Number of responses in last shaping day	0.3	0.3	0.8	-0.0	-0.9	-0.3	0.5
Context. condit. distance diff. score	1.0	1.2	3.9	0.1	0.5	2.0	-0.9
Locomotion velocity, session 1	0.3	0.3	1.0	0.0	-1.0	-0.4	0.0
Locomotion distance, session 1	0.6	0.7	2.0	-0.2	-1.4	0.8	-0.5
Locomotion velocity, session 2	0.4	0.5	1.0	-1.0	-1.0	-0.1	-0.2
Locomotion distance, session 2	2.3	3.2	10.1	-1.6	-3.2	-0.3	0.2
Locomotion velocity, session 3	0.1	0.2	0.3	-0.1	-0.6	-0.1	0.5
Locomotion distance, session 3	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.1
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.1	-0.0	-0.7	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.2	1.1	0.9	-0.2	-0.0
Locomotion velocity, session 7	0.4	0.4	0.8	0.3	0.1	0.8	-0.9
Locomotion distance, session 7	1.4	1.8	4.8	0.1	-0.2	2.2	-1.5
Stereotopy head waving bouts, day 7	2.2	2.5	4.4	-1.0	-1.0	-2.1	1.9
Stereotopy head waving duration, day 7	3.4	4.1	6.7	-1.3	-1.5	-2.6	2.4
Locomotion velocity, session 8	0.2	0.3	0.6	-0.7	-0.8	0.3	-0.2
Locomotion distance, session 8	1.4	2.0	3.9	-0.4	-1.7	2.0	-1.1
Degree of sensitization distance	1.6	1.6	3.5	0.5	0.6	1.9	-1.6
Degree of sensitization stereotypy	3.1	3.3	6.3	-1.0	-1.4	-2.5	2.0
Condit. Reinf. active minus inactive responses	0.8	0.9	1.7	0.9	-0.1	1.3	-0.9
Condit. Reinf. active-inactive response ratio	3.2	3.4	6.2	2.5	1.2	1.8	-1.7
Condit. Reinf. active responses	0.6	0.8	2.4	-0.8	-1.6	0.3	-0.1
Condit. Reinf. inactive responses	3.1	3.6	5.4	-2.3	-2.1	-1.6	1.4
Incentive salience index mean	0.6	0.7	1.1	0.8	0.3	1.1	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.3	0.1	0.5	-0.1	0.1
Time in familiar zone, hab. session 1	0.4	0.3	1.2	-0.2	-0.2	-0.3	1.1
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.0	0.2	-0.5	-0.0
Total zone transitions, hab. session 1	1.2	1.7	5.4	-0.5	-2.3	-0.4	0.9
Total locomotion distance, hab. session 1	0.4	0.6	1.3	-1.0	-1.1	0.3	0.4
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.7	-0.8	0.7	-0.3
Time in familiar zone, hab. session 2	1.2	1.3	2.6	1.2	1.6	-0.6	-0.8
Time in novel zone, hab. session 2	1.2	1.2	2.6	-1.1	-1.6	0.7	0.8
Total zone transitions, hab. session 2	0.5	0.6	2.2	0.2	-1.5	0.4	0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.2	-0.5	0.8	-0.9
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.2	-0.7	0.8	-0.7
Novel to familiar place preference ratio	0.4	0.4	0.8	0.4	-0.6	0.9	-0.6
Novelty place preference	0.6	0.6	1.0	0.5	-0.6	1.0	-0.9
Time in novel zone, NPP test	0.6	0.7	1.0	0.7	-0.5	1.0	-1.0
Total zone transitions, NPP test	0.3	0.5	0.6	0.7	-0.7	0.6	-0.8
Total locomotion distance, NPP test	0.7	1.0	2.0	0.5	0.4	1.4	-1.3
Locomotion velocity, NPP test	1.0	1.4	2.6	0.7	0.6	1.5	-1.6
Pavlov. Cond. lever latency	0.4	0.5	1.7	1.3	0.0	-0.2	-0.6
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	-0.2	-0.9	-0.3	0.7
Pavlov. Cond. change in total contacts	0.9	1.0	2.0	-1.2	-1.4	0.4	0.5
Pavlov. Cond. index score	0.1	0.2	0.6	-0.8	-0.3	0.1	0.3
Pavlov. Cond. latency score	0.2	0.3	1.0	-1.0	-0.3	0.1	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.2	0.5	0.2	-0.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.1	0.9	0.0	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.0	0.2	0.7	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.8	-0.4	0.3	-0.1
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.3	-0.4	0.0	0.6
Bone: apparent density	0.2	0.4	1.3	0.5	1.1	0.1	0.0
Bone surface	0.2	0.3	0.7	0.5	0.8	-0.4	0.3
Bone volume	0.4	0.6	1.0	0.5	1.0	-0.9	0.6
Bone: connectivity density	0.2	0.3	0.8	-0.3	0.5	0.9	0.0
Bone: cortical apparent density	0.2	0.3	0.7	0.5	0.2	0.8	-0.5
Bone: cortical area	2.9	4.4	8.4	2.9	2.8	0.1	-1.1
Bone: cortical porosity	0.4	0.4	1.0	0.1	-0.6	-1.0	0.6
Bone: cortical porosity	0.2	0.2	0.5	0.5	-0.4	-0.7	0.2
Bone: cortical thickness	3.5	5.8	11.0	3.3	3.2	0.4	-1.3
Bone: cortical thickness	1.2	1.4	2.5	1.6	1.3	-0.7	-0.9
Bone: cortical tissue density	0.3	0.3	0.8	0.5	0.2	0.9	-0.5
Bone: elastic displacement	1.3	1.5	3.0	1.7	1.6	0.1	-0.6
Bone: elastic work	3.5	4.6	8.3	2.9	2.8	0.5	-1.5
Bone: endosteal estimation	0.0	0.1	0.2	-0.2	0.0	-0.5	0.3
Bone: endosteal perimeter	0.1	0.3	0.6	0.4	0.5	-0.7	0.5
Bone: final force	1.0	1.7	2.3	1.5	1.5	1.2	-0.9
Bone: final moment	1.1	1.8	2.7	1.5	1.6	1.1	-1.0
Bone: marrow area	0.0	0.1	0.2	-0.3	-0.0	-0.4	0.2
Bone: maximum diameter	0.5	0.9	2.2	1.1	1.5	-0.2	-0.3
Bone: maximum force	1.1	1.9	4.3	1.4	2.1	1.0	-0.5
Bone: maximum moment	1.1	1.9	4.6	1.3	2.1	0.9	-0.6
Bone: minimum diameter	1.1	2.1	5.4	2.3	1.5	-0.2	-0.8
Bone: periosteal estimation	0.7	1.4	2.9	1.7	1.6	-0.4	-0.5
Bone: periosteal perimeter	0.8	1.3	2.7	1.6	1.3	-0.9	0.1
Bone: post-yield work	0.8	1.1	2.8	-1.7	-0.1	0.0	1.2
Bone: stiffness	0.7	1.2	2.0	1.2	1.4	0.8	-0.8
Bone: tissue strength	2.5	2.5	4.1	1.6	2.0	1.5	-1.0
Bone: trabecular number	0.5	0.7	2.2	-0.6	-0.2	-0.6	1.5
Bone: trabecular spacing	1.1	1.5	3.3	0.7	1.0	1.1	-1.8
Bone: trabecular thickness	0.5	0.5	1.0	0.0	-0.6	-1.0	0.9
Bone: trabecular tissue density	0.8	1.1	1.5	-1.2	-1.1	-1.2	0.5
Breakpoint value in progressive ratio session	2.4	2.7	4.7	0.9	1.1	2.2	-2.0
Distance traveled before self-admin	0.4	0.4	0.7	0.4	0.8	-0.8	0.2
Distance traveled after self-admin	0.8	0.9	1.3	0.8	1.1	0.9	-0.9
Delta time in closed arm before/after self-admin	0.9	0.9	1.6	-0.6	-1.1	-0.6	1.3
Delta time in open arm before/after self-admin	0.9	0.9	1.2	-0.6	-1.1	-1.1	0.9
Diff in mean of infusions in LGA sessions	1.9	2.1	4.2	-0.0	0.7	1.9	-2.0
Extinction: sum of active levers before priming	3.2	3.2	5.4	2.3	1.4	1.0	-2.1
Active lever presses in extinction session 6	0.8	0.7	2.4	-0.4	-0.3	1.6	-0.5
Delta distance traveled before/after self-admin	0.8	0.9	2.6	0.1	-0.1	1.6	-0.9
Delta ambulatory time before/after self-admin	1.0	1.1	3.3	0.1	-0.1	1.8	-1.0
Time in closed arm before self-admin	0.5	0.5	1.5	-0.1	0.6	1.2	-0.4
Time in closed arm after self-admin	0.7	0.7	2.6	-0.5	0.0	1.6	-0.0
Time in open arm before self-admin	1.4	1.5	2.7	1.6	1.1	-0.3	-1.4
Time in open arm after self-admin	0.6	0.7	2.2	0.6	-0.4	-1.5	0.3
Sum of active levers in priming session hrs 5-6	2.3	2.3	4.3	0.6	1.4	1.6	-2.1
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.6	-1.6	-1.0	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.8	-0.2	0.8	-1.3	1.3
Time to tail flick, test, before self-admin	1.8	1.8	3.0	-1.7	-1.4	-0.7	1.2
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.4	0.4	0.2	-0.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.7	1.0	1.3	-0.4	0.6
Delta time to tail flick, test, before/after SA	0.8	0.7	1.7	1.3	0.8	0.5	-0.6
Ambulatory time before self-admin	0.3	0.3	0.8	0.2	0.5	-0.9	0.1
Ambulatory time after self-admin	0.2	0.2	0.5	-0.1	0.5	0.7	-0.2
Total heroin consumption	0.3	0.3	0.5	0.3	0.6	0.7	-0.6
Area under the delay curve	0.8	0.8	2.2	-1.0	-1.5	-0.1	0.2
Delay disc. indifference point, 0s delay	0.4	0.4	1.2	-0.7	-0.3	0.1	1.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.0	-0.5	0.6	-0.3
Delay disc. indifference point, 2s delay	1.2	1.3	2.1	-1.0	-0.9	-1.2	1.5
Delay disc. indifference point, 24s delay	1.1	1.1	2.1	-1.5	-1.3	-0.6	0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.2	-0.6	0.6	-0.5
Delay disc. indifference point, 8s delay	2.3	2.4	6.4	-1.5	-2.5	-0.8	0.5
Delay discount exponential model param	0.9	0.9	2.5	1.1	1.6	0.2	-0.1
Delay discount hyperbolic model param	0.8	0.9	2.2	1.2	1.5	0.2	-0.2
Fecal boli incidents, locomotor time 1	0.8	0.9	1.6	-1.2	-0.7	-0.9	0.8
Change in fecal boli incidents, locomotor task	0.7	0.7	2.2	0.1	-0.2	0.7	-1.5
Time >=10cm from walls, locomotor time 1	2.1	2.1	3.1	0.7	1.7	1.8	-1.4
Bouts of movement, locomotor time 1	0.8	0.9	1.5	0.6	1.1	0.6	-1.2
Total resting periods, locomotor time 1	0.5	0.5	0.9	0.4	0.8	0.6	-1.0
Rest time, locomotor task time 1	0.9	1.0	1.4	-1.0	-0.5	-1.2	1.1
Distance moved, locomotor task time 1	0.5	0.6	1.4	0.6	0.1	0.8	-1.2
Vertical activity count, locomotor time 1	0.5	0.5	0.7	0.8	0.3	0.8	-0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	-0.2	-0.5	0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	-0.5	-0.1	0.3
Total resting periods, locomotor time 2	0.3	0.3	0.9	-1.0	-0.6	-0.0	0.3
Rest time, locomotor task time 2	0.5	0.6	1.0	-1.0	-0.5	-0.9	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.1	-0.3	0.3	0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.8	0.1	-0.2	0.5
Weight adjusted by age	0.6	0.6	1.8	-0.8	-1.4	0.0	0.1
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	3.2	-1.8	-1.4	-0.7	0.7
Locomotion in novel chamber	0.2	0.3	0.7	-0.4	0.9	0.3	-0.2
Locomotion in novel chamber post-restriction	0.7	0.8	1.6	-0.8	-0.9	-1.3	0.2
Progressive ratio	0.7	0.9	2.4	0.7	0.5	-1.6	0.5
Food seeking constrained by brief footshock	1.9	2.4	3.6	1.9	1.9	0.9	-1.3
Seeking ratio, punishment vs. effort	1.0	1.2	3.3	0.2	0.2	1.8	-1.2
Run reversals in cocaine runway, females	0.4	0.4	0.9	-0.5	-0.4	0.3	-1.0
Run reversals in cocaine runway, males	0.7	0.7	1.7	0.4	-0.7	0.5	-1.3
Latency to leave start box in cocaine runway	0.5	0.5	0.7	-0.7	-0.6	0.8	-0.8
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	-0.3	-0.2	0.7	-0.4
Latency to leave start box in cocaine runway, M	0.9	0.9	1.8	-0.7	0.5	1.3	-1.0
Cd content in liver	0.7	0.8	1.4	0.9	0.5	1.2	-0.9
Co content in liver	0.3	0.4	1.2	1.1	-0.6	-0.0	-0.1
Cu content in liver	1.3	1.6	4.4	-1.1	-0.2	2.1	-0.9
Fe content in liver	0.4	0.5	1.2	-1.1	-0.6	0.1	0.7
K content in liver	0.3	0.3	1.1	-1.0	0.3	-0.1	-0.3
Mg content in liver	0.4	0.4	1.1	-1.0	-0.2	0.4	-0.5
Mn content in liver	0.9	1.0	1.7	0.8	1.3	-0.1	-1.3
Na content in liver	0.3	0.3	0.8	-0.9	-0.4	-0.6	0.2
Rb content in liver	0.2	0.3	0.4	-0.6	-0.6	0.5	0.3
Se content in liver	0.0	0.0	0.1	-0.1	-0.4	-0.1	0.1
Sr content in liver	0.5	0.5	1.0	0.2	-0.8	-1.0	-0.2
Zn content in liver	3.1	3.4	9.2	-1.8	0.4	3.0	-1.1