Hub : Traits

Locomotor testing rearing

Rearing measured with photo beam sensors placed 15 cm above the floor in a novel 24 X 45 cm chamber in the 18-minute session for males and females [n beam breaks/18 min test]

Tags: Behavior · Locomotion

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	76033161	77431053	1	1	5.25e-09	3.30e-05	2.17e-08	Fnbp4
2	chr9	75969545	77365260	1	1	2.69e-35	1.62e-03	1.00e+00	Zfand2b
3	chr10	24487967	25881097	1	1	1.98e-07	4.63e-07	3.71e-01	Ccng1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	33.3	0	1e+00	Zfand2b
BMI without tail	28.47	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Body weight	1.66	1	0	0	0	1e+00	Ccng1
Epididymis fat weight	57.86	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Glucose	4.21	1	0	0	0	1e+00	Fnbp4
Heart weight	71.7	1	1	33.3	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	33.3	0	1e+00	Zfand2b
Right kidney weight	54.05	1	1	33.3	0	1e+00	Zfand2b
Tail length	125.62	1	1	33.3	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	40.72	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Liver weight, right	17.57	1	1	33.3	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1e+00	Zfand2b
Intraocular pressure	51.69	1	1	33.3	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	33.3	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	11.43	2	0	0	0	1e+00	Fnbp4 Zfand2b
Water consumed over 24 hours	34.33	1	1	33.3	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1e+00	Zfand2b
Patch foraging indifference point AUC	15.46	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Indifference point function ln k	54.42	1	1	33.3	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	43.37	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Patch foraging total patch changes 6 sec	15.59	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	21.54	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	33.3	0	1e+00	Zfand2b
Locomotor activity	9.09	3	0	0	0	1e+00	Ccng1 Fnbp4 Zfand2b
Locomotor testing distance	26.15	3	2	66.7	0	1e+00	Ccng1 Fnbp4 Zfand2b
Light reinforcement 1	19.25	1	1	33.3	0	1e+00	Zfand2b
Light reinforcement 2	7.48	3	0	0	0	1e+00	Ccng1 Fnbp4 Zfand2b
Reaction time number correct	60.63	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time mean minus median	94.86	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time mean minus median AUC	121.98	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time num false alarms	4.96	2	0	0	0	1e+00	Fnbp4 Zfand2b
Reaction time num false alarms AUC	16.11	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Reaction time trials correct on left	60.63	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time trials on left	56.43	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time mean	23.51	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time mean AUC	23.18	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Median of all reaction times	12.47	2	0	0	0	1e+00	Ccng1 Zfand2b
Reaction time omissions	46.56	1	1	33.3	0	1e+00	Zfand2b
Reaction time false alarm rate	4.37	1	0	0	0	1e+00	Fnbp4
Reaction time premature initiations	41.6	1	1	33.3	0	1e+00	Zfand2b
Std. dev. reaction times	41.44	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time trials completed	56.43	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Reaction time trials AUC	57.63	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Social response proportion	9.16	2	0	0	0	1e+00	Fnbp4 Zfand2b
Social time	24.43	1	1	33.3	0	1e+00	Fnbp4
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	79.66	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	33.3	0	1e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	85.16	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Intermittent access intake escalation	63.23	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Intermittent access intake escalation 2	19.63	1	0	0	0	1e+00	Fnbp4
Intermitt. access day 1 inactive lever presses	169.63	1	1	33.3	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	153.87	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	33.3	0	1e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	33.3	0	1e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	16.48	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Intermittent access total infusions	5.54	1	0	0	0	1e+00	Ccng1
Intermittent access day 1 locomotion	26.47	1	1	33.3	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	33.3	0	1e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Intermittent access standard deviation	154.61	3	1	33.3	0	1e+00	Ccng1 Fnbp4 Zfand2b
Cocaine induced anxiety	65.57	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Baseline Anxiety	200.93	2	1	33.3	0	1e+00	Ccng1 Zfand2b
Incentive Sensitization - Responses	159.96	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Incentive Sensitization - Breakpoint	105.55	3	1	33.3	0	1e+00	Ccng1 Fnbp4 Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	33.3	0	1e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	33.3	0	1e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	33.3	0	1e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	33.3	0	1e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	33.3	0	1e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	33.3	0	1e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	33.3	0	1e+00	Zfand2b
Short access total locomotion	209.96	1	1	33.3	0	1e+00	Zfand2b
Compulsive drug intake	68.39	1	1	33.3	0	1e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	33.3	0	1e+00	Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Degree of sensitization stereotypy	8.3	1	0	0	0	1e+00	Fnbp4
Total zone transitions, hab. session 2	5.02	1	0	0	0	1e+00	Fnbp4
Total locomotion distance, hab. session 2	5.36	1	0	0	0	1e+00	Fnbp4
Locomotion velocity, hab. session 2	5.82	1	0	0	0	1e+00	Fnbp4
Total locomotion distance, NPP test	4.42	1	0	0	0	1e+00	Fnbp4
Locomotion velocity, NPP test	4.11	1	0	0	0	1e+00	Fnbp4
Bone: cortical thickness	4.07	1	0	0	0	1e+00	Ccng1
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Distance traveled before self-admin	5.58	1	0	0	0	1e+00	Zfand2b
Distance traveled after self-admin	8.9	1	0	0	0	1e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1e+00	Zfand2b
Delta ambulatory time before/after self-admin	6.19	1	0	0	0	1e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	33.3	0	1e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	33.3	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	33.3	0	1e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1e+00	Zfand2b
Area under the delay curve	31.15	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.57	2	0	0	0	1e+00	Ccng1 Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	17.81	2	0	0	0	1e+00	Ccng1 Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	33.3	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	33.3	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	33.3	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	10.21	2	0	0	0	1e+00	Fnbp4 Zfand2b
Distance moved, locomotor task time 1	12.62	2	0	0	0	1e+00	Ccng1 Fnbp4
Vertical activity count, locomotor time 1	97.7	1	1	33.3	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	33.3	0	1e+00	Zfand2b
Rest time, locomotor task time 2	23.7	3	1	33.3	0	1e+00	Ccng1 Fnbp4 Zfand2b
Distance moved, locomotor task time 2	34.63	3	1	33.3	0	1e+00	Ccng1 Fnbp4 Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	10.29	2	0	0	0	1e+00	Fnbp4 Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	19.15	2	1	33.3	0	1e+00	Fnbp4 Zfand2b
Cd content in liver	24.93	1	1	33.3	0	1e+00	Ccng1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.56
Adipose	alternative TSS	0	0	1.39
Adipose	gene expression	0	0	1.53
Adipose	isoform ratio	1	0	1.54
Adipose	intron excision ratio	0	0	1.53
Adipose	mRNA stability	0	0	1.6
BLA	alternative polyA	0	0	1.49
BLA	alternative TSS	0	0	1.54
BLA	gene expression	0	0	1.57
BLA	isoform ratio	0	0	1.52
BLA	intron excision ratio	0	0	1.61
BLA	mRNA stability	0	0	1.6
Brain	alternative polyA	0	0	1.46
Brain	alternative TSS	0	0	1.64
Brain	gene expression	0	0	1.56
Brain	isoform ratio	0	0	1.51
Brain	intron excision ratio	0	0	1.56
Brain	mRNA stability	0	0	1.56
Eye	alternative polyA	0	0	1.59
Eye	alternative TSS	0	0	1.66
Eye	gene expression	0	0	1.54
Eye	isoform ratio	0	0	1.53
Eye	intron excision ratio	0	0	1.48
Eye	mRNA stability	0	0	1.34
IL	alternative polyA	0	0	1.42
IL	alternative TSS	0	0	1.62
IL	gene expression	0	0	1.57
IL	isoform ratio	0	0	1.6
IL	intron excision ratio	0	0	1.65
IL	mRNA stability	0	0	1.63
LHb	alternative polyA	0	0	1.43
LHb	alternative TSS	0	0	1.71
LHb	gene expression	0	0	1.53
LHb	isoform ratio	0	0	1.58
LHb	intron excision ratio	0	0	1.5
LHb	mRNA stability	0	0	1.62
Liver	alternative polyA	0	0	1.58
Liver	alternative TSS	0	0	1.54
Liver	gene expression	0	0	1.54
Liver	isoform ratio	0	0	1.49
Liver	intron excision ratio	0	0	1.48
Liver	mRNA stability	0	0	1.55
NAcc	alternative polyA	0	0	1.5
NAcc	alternative TSS	0	0	1.62
NAcc	gene expression	0	0	1.56
NAcc	isoform ratio	0	0	1.51
NAcc	intron excision ratio	0	0	1.52
NAcc	mRNA stability	0	0	1.58
OFC	alternative polyA	0	0	1.45
OFC	alternative TSS	0	0	1.62
OFC	gene expression	0	0	1.57
OFC	isoform ratio	0	0	1.57
OFC	intron excision ratio	0	0	1.51
OFC	mRNA stability	0	0	1.63
PL	alternative polyA	0	0	1.52
PL	alternative TSS	0	0	1.61
PL	gene expression	1	0	1.57
PL	isoform ratio	0	0	1.51
PL	intron excision ratio	1	0	1.56
PL	mRNA stability	0	0	1.56
pVTA	alternative polyA	0	0	1.54
pVTA	alternative TSS	0	0	1.68
pVTA	gene expression	0	0	1.51
pVTA	isoform ratio	0	0	1.59
pVTA	intron excision ratio	0	0	1.61
pVTA	mRNA stability	0	0	1.62
RMTg	alternative polyA	0	0	1.29
RMTg	alternative TSS	0	0	1.65
RMTg	gene expression	0	0	1.55
RMTg	isoform ratio	0	0	1.47
RMTg	intron excision ratio	0	0	1.51
RMTg	mRNA stability	0	0	1.55