Hub : Genes

Cst6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000020455 0.37 0.12 0.0e+00 0.18 0.22 0.22 0.2 2.7e-19 1.3e-23 2.2e-24 2.2e-22
2 BLA gene expression ENSRNOG00000020455 0.18 0.09 7.6e-10 0.18 0.17 0.18 0.18 7.7e-10 1.4e-09 7.7e-10 5.7e-10
3 Brain gene expression ENSRNOG00000020455 0.04 0.04 4.1e-03 0.03 0.01 0.01 0.02 1.9e-03 1.5e-02 1.9e-02 5.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.47.814.43.82.8-1.0
BMI without tail1.42.84.92.21.6-1.1
Body weight1.77.217.81.14.21.6
Epididymis fat weight2.04.67.80.9-2.8-2.2
Glucose2.74.25.71.8-1.9-2.4
Heart weight2.13.05.00.9-2.2-1.7
Left kidney weight0.41.12.4-0.3-1.5-0.9
Right kidney weight0.30.91.8-1.4-0.80.5
Tail length1.23.64.3-2.11.52.0
Length with tail2.07.49.5-1.83.13.1
Length without tail2.04.36.5-0.72.62.4
Liver weight, left0.00.10.2-0.1-0.4-0.2
Liver weight, right0.00.00.00.1-0.2-0.2
Parametrial fat weight2.65.16.31.8-2.4-2.5
Retroperitoneal fat weight3.611.721.41.2-4.6-3.5
Intraocular pressure0.91.32.0-1.4-1.30.5
Extensor digitorum longus weight3.815.234.6-0.15.93.3
Soleus weight2.46.914.50.1-3.8-2.5
Tibialis anterior weight7.626.242.1-2.36.55.6
Tibia length1.23.45.0-1.71.52.2
Number of licking bursts0.20.20.4-0.10.60.5
Food consumed during 24 hour testing period0.70.81.5-1.20.11.0
Times rat made contact with spout0.40.40.80.70.9-0.1
Mean time between licks in bursts0.40.51.0-0.21.00.7
Mean num. licks in bursts0.30.30.50.6-0.4-0.7
Std. dev. time between licks in bursts0.10.10.3-0.5-0.00.3
Water consumed over 24 hours0.50.61.2-0.21.10.8
Indifference point 0 sec0.00.10.10.3-0.2-0.3
Indifference point AUC2.52.94.4-0.42.12.0
Indifference point function ln k4.76.712.10.2-3.5-2.8
Indifference point function log k4.76.712.10.2-3.5-2.8
Delay discounting total patch changes 0 sec0.00.00.0-0.1-0.1-0.0
Delay discounting total patch changes 12 sec2.43.26.80.32.61.6
Delay discounting total patch changes 18 sec0.30.40.60.60.80.3
Delay discounting total patch changes 24 sec1.82.23.3-0.51.81.8
Delay discounting total patch changes 6 sec0.71.02.00.61.40.8
Delay discounting time to switch 0 sec1.32.03.01.71.6-0.4
Delay discounting water rate 0 sec2.23.56.6-1.9-2.6-0.3
Delay discounting water rate 12 sec3.75.612.9-1.5-3.6-1.3
Delay discounting water rate 18 sec1.52.04.5-0.5-2.1-1.1
Delay discounting water rate 24 sec2.23.06.7-1.2-2.6-0.9
Delay discounting water rate 6 sec1.62.35.2-1.2-2.3-0.5
Locomotor activity0.71.12.5-0.9-1.6-0.3
Locomotor testing distance0.91.53.5-0.8-1.9-0.5
Locomotor testing rearing1.01.63.20.2-1.8-1.3
Light reinforcement 10.10.10.2-0.3-0.5-0.0
Light reinforcement 20.60.71.5-0.8-1.2-0.2
Reaction time number correct0.50.81.0-1.00.70.9
Reaction time mean minus median1.92.43.9-0.32.01.8
Reaction time mean minus median AUC1.72.23.4-0.91.51.9
Reaction time num false alarms0.10.10.3-0.5-0.10.2
Reaction time num false alarms AUC0.20.30.4-0.50.60.6
Reaction time trials correct on left0.50.81.0-1.00.70.9
Reaction time trials on left0.71.01.2-1.10.81.1
Reaction time mean0.10.10.3-0.30.00.6
Reaction time mean AUC0.00.10.1-0.2-0.00.4
Median of all reaction times0.00.10.2-0.1-0.4-0.0
Reaction time omissions1.11.52.2-0.51.51.4
Reaction time false alarm rate0.00.00.0-0.1-0.10.0
Reaction time premature initiation rate2.02.64.2-0.62.01.8
Reaction time premature initiations3.44.96.8-1.32.62.5
Std. dev. reaction times0.71.01.8-0.41.01.4
Reaction time trials completed0.71.01.2-1.10.81.1
Reaction time trials AUC0.40.60.8-0.90.60.8
Social response proportion0.40.51.00.41.00.5
Social responses0.30.40.6-0.30.70.7
Social time0.40.50.9-0.50.61.0
Conditioned locomotion1.01.22.4-0.51.50.9
Cocaine response after cond. corrected0.80.91.40.3-1.2-1.1
Cocaine response after cond. not corrected0.60.71.00.3-1.0-1.0
Cocaine response before conditioning0.40.50.7-0.20.80.9
Saline control response2.22.96.20.22.51.5
Condit. Reinf. active minus inactive responses0.10.20.30.4-0.5-0.3
Condit. Reinf. active-inactive response ratio0.50.51.10.3-1.1-0.6
Condit. Reinf. active responses0.30.41.01.00.1-0.5
Condit. Reinf. inactive responses0.70.81.61.30.7-0.6
Condit. Reinf. lever presses1.11.63.20.11.81.2
Condit. Reinf. lever reinforcers received0.20.30.60.80.4-0.2
Pavlov. Cond. lever latency0.20.30.60.1-0.8-0.6
Pavlov. Cond. magazine entry latency1.92.25.00.62.21.1
Pavlov. Cond. change in total contacts0.81.12.20.41.51.0
Pavlov. Cond. index score1.11.53.20.31.81.1
Pavlov. Cond. latency score0.91.22.60.21.61.0
Pavlov. Cond. lever contacts0.50.81.2-0.70.81.1
Pavlov. Cond. magazine entry number3.34.18.8-0.5-3.0-1.8
Pavlov. Cond. intertrial magazine entries0.81.02.0-0.2-1.4-1.0
Pavlov. Cond. lever-magazine prob. diff.1.41.84.00.32.01.1
Pavlov. Cond. response bias1.11.52.6-0.21.61.4
Conditioned reinforcement - actives0.20.20.4-0.6-0.50.1
Conditioned reinforcement - inactives3.13.58.1-0.4-2.9-1.5
Conditioned locomotion4.14.911.4-0.9-3.4-1.5
Intermittent access intake day 1-15 change0.70.71.4-1.2-0.80.2
Intermittent access intake escalation0.40.40.7-0.7-0.8-0.1
Intermittent access intake escalation 20.70.71.5-1.2-0.50.5
Intermitt. access day 1 inactive lever presses1.31.42.90.2-1.7-1.2
Intermitt. access day 15 inactive lever presses1.21.32.8-0.1-1.7-1.0
Intermitt. access escalation Index3.93.54.91.5-1.9-2.2
Intermittent access day 1 total infusions7.07.911.92.4-2.5-3.4
Intermittent access day 15 total infusions5.15.79.70.8-3.1-2.6
Intermittent access terminal intake (last 3 days)4.04.46.50.9-2.5-2.4
Intermittent access total infusions4.75.27.81.7-2.2-2.8
Intermittent access day 1 locomotion6.06.19.62.4-1.8-3.1
Intermittent access day 15 total locomotion3.53.75.70.8-2.4-2.2
Intermittent access total locomotion6.97.811.52.1-2.7-3.4
Intermittent access standard deviation0.60.61.2-0.5-1.1-0.6
Cocaine induced anxiety0.10.10.3-0.5-0.00.3
Post-drug Anxiety2.12.33.8-1.31.21.9
Baseline Anxiety2.12.23.3-0.81.71.8
Lifetime Intake4.75.28.21.9-2.0-2.9
Incentive Sensitization - Responses0.40.40.80.4-0.6-0.9
Incentive Sensitization - Breakpoint0.50.50.90.3-0.8-0.9
Progressive ratio test 1 active lever presses1.91.92.80.4-1.7-1.7
Progressive ratio test 1 breakpoint1.51.62.50.2-1.6-1.5
Progressive ratio test 1 inactive lever presses1.11.21.80.6-1.1-1.4
Progressive ratio test 2 active lever presses2.72.94.50.5-2.1-2.0
Progressive ratio test 2 breakpoint2.83.26.00.0-2.4-1.9
Progressive ratio test 2 inactive lever presses5.86.711.01.0-3.3-2.9
Total sessions with >9 infusions2.32.54.11.3-1.3-2.0
Short access day 1 total inactive lever presses2.73.05.00.8-2.2-1.9
Short access day 10 total inactive lever presses1.82.03.70.2-1.9-1.5
Short access day 1 total infusions5.15.58.92.1-1.8-3.0
Short access day 10 total infusions5.25.88.42.8-1.0-2.9
Short access total infusions3.33.65.92.0-1.0-2.4
Short access day 1 locomotion3.94.16.61.9-1.5-2.6
Short access day 10 total locomotion3.43.76.01.9-1.2-2.4
Short access total locomotion3.33.45.61.8-1.0-2.4
Compulsive drug intake2.02.03.2-0.61.81.6
One hour access (0.3 mA shock)5.86.712.30.4-3.5-2.8
One hour access (shock baseline)5.15.911.50.3-3.4-2.5
Number of responses in last shaping day0.50.61.1-0.3-1.0-0.7
Context. condit. distance diff. score1.72.13.50.4-1.6-1.9
Locomotion velocity, session 10.10.10.2-0.40.10.1
Locomotion distance, session 11.01.32.51.60.9-0.7
Locomotion velocity, session 21.31.53.70.61.90.7
Locomotion distance, session 20.71.01.81.31.2-0.1
Locomotion velocity, session 30.50.61.01.0-0.2-0.8
Locomotion distance, session 30.00.00.00.1-0.1-0.1
Stereotopy head waving bouts, day 31.11.41.91.2-0.8-1.4
Stereotopy head waving duration, day 31.01.31.70.9-1.1-1.3
Locomotion velocity, session 71.71.92.91.7-0.6-1.5
Locomotion distance, session 70.50.61.21.10.0-0.7
Stereotopy head waving bouts, day 70.30.40.40.7-0.6-0.6
Stereotopy head waving duration, day 70.50.60.90.90.90.1
Locomotion velocity, session 80.80.91.6-0.51.31.0
Locomotion distance, session 80.50.81.30.9-0.5-1.2
Degree of sensitization distance0.60.61.21.10.1-0.7
Degree of sensitization stereotypy0.20.20.30.30.60.4
Condit. Reinf. active minus inactive responses0.20.20.30.50.6-0.1
Condit. Reinf. active-inactive response ratio0.00.00.10.20.2-0.1
Condit. Reinf. active responses0.20.20.30.50.4-0.3
Condit. Reinf. inactive responses0.20.20.30.5-0.1-0.6
Incentive salience index mean0.40.50.70.80.7-0.3
Condit. Reinf. lever presses0.10.20.50.10.70.1
Time in familiar zone, hab. session 10.40.30.50.6-0.4-0.7
Time in novel zone, hab. session 10.20.20.4-0.6-0.40.3
Total zone transitions, hab. session 10.30.51.20.31.10.3
Total locomotion distance, hab. session 10.40.60.90.7-0.7-1.0
Locomotion velocity, hab. session 10.20.30.40.6-0.2-0.6
Time in familiar zone, hab. session 20.10.10.3-0.50.20.2
Time in novel zone, hab. session 20.30.30.90.90.1-0.4
Total zone transitions, hab. session 22.22.86.02.51.3-0.9
Total locomotion distance, hab. session 21.51.93.61.9-0.2-1.4
Locomotion velocity, hab. session 21.42.03.41.8-0.4-1.5
Novel to familiar place preference ratio0.40.40.80.20.90.7
Novelty place preference0.20.20.20.30.50.4
Time in novel zone, NPP test0.10.10.10.30.40.3
Total zone transitions, NPP test1.01.43.31.01.80.1
Total locomotion distance, NPP test0.30.51.01.00.1-0.6
Locomotion velocity, NPP test0.20.30.80.90.2-0.5
Pavlov. Cond. lever latency0.10.10.3-0.3-0.5-0.1
Pavlov. Cond. magazine entry latency0.40.61.31.10.2-0.6
Pavlov. Cond. change in total contacts0.00.00.10.30.10.0
Pavlov. Cond. index score0.00.10.1-0.10.30.3
Pavlov. Cond. latency score0.00.00.00.20.2-0.0
Pavlov. Cond. lever contacts0.00.00.00.10.10.0
Pavlov. Cond. magazine entry number0.20.30.50.5-0.4-0.7
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.6-0.60.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.00.50.4
Pavlov. Cond. response bias0.10.10.2-0.40.30.5
Bone: apparent density1.22.04.82.20.7-0.9
Bone surface1.83.26.81.42.61.0
Bone volume0.91.52.51.61.40.1
Bone: connectivity density1.62.64.22.01.9-0.1
Bone: cortical apparent density0.20.20.3-0.10.60.5
Bone: cortical area0.71.01.4-0.71.11.2
Bone: cortical porosity0.60.71.21.10.2-0.9
Bone: cortical porosity0.50.50.80.90.7-0.4
Bone: cortical thickness3.15.16.3-1.82.52.4
Bone: cortical thickness1.41.72.4-1.21.11.5
Bone: cortical tissue density0.20.30.4-0.20.70.7
Bone: elastic displacement0.60.71.4-1.2-0.80.2
Bone: elastic work0.91.21.4-0.91.21.2
Bone: endosteal estimation1.53.34.11.9-1.5-2.0
Bone: endosteal perimeter1.93.95.01.9-1.8-2.2
Bone: final force1.32.14.80.12.21.2
Bone: final moment1.11.94.30.12.11.1
Bone: marrow area1.73.64.52.0-1.6-2.1
Bone: maximum diameter0.20.30.5-0.60.30.7
Bone: maximum force1.42.55.71.22.40.6
Bone: maximum moment1.32.24.91.12.20.6
Bone: minimum diameter2.34.25.72.4-1.2-2.3
Bone: periosteal estimation0.10.10.30.5-0.2-0.3
Bone: periosteal perimeter0.10.10.30.50.2-0.1
Bone: post-yield work4.05.412.23.50.3-2.0
Bone: stiffness1.11.83.91.22.00.2
Bone: tissue strength0.00.00.10.30.1-0.1
Bone: trabecular number0.71.22.81.70.8-0.3
Bone: trabecular spacing0.10.10.2-0.3-0.5-0.2
Bone: trabecular thickness1.01.21.61.3-0.7-1.2
Bone: trabecular tissue density1.92.75.9-0.6-2.4-1.3
Breakpoint value in progressive ratio session2.12.34.2-0.42.01.6
Distance traveled before self-admin0.20.20.4-0.10.70.5
Distance traveled after self-admin0.10.10.3-0.20.30.5
Delta time in closed arm before/after self-admin0.10.10.20.10.4-0.2
Delta time in open arm before/after self-admin0.40.30.6-0.70.10.8
Diff in mean of infusions in LGA sessions0.60.71.1-0.70.61.1
Extinction: sum of active levers before priming2.22.25.20.62.31.0
Active lever presses in extinction session 63.13.04.3-1.51.62.1
Delta distance traveled before/after self-admin0.00.00.0-0.2-0.20.2
Delta ambulatory time before/after self-admin0.00.00.1-0.2-0.00.3
Time in closed arm before self-admin0.00.00.10.1-0.00.3
Time in closed arm after self-admin0.10.10.10.40.0-0.3
Time in open arm before self-admin0.60.61.30.5-0.5-1.1
Time in open arm after self-admin0.20.20.5-0.7-0.40.3
Sum of active levers in priming session hrs 5-64.14.05.5-2.31.12.3
Time to tail flick, vehicle, before self-admin0.30.30.50.70.7-0.1
Time to tail flick, vehicle, after self-admin1.01.01.81.11.3-0.1
Time to tail flick, test, before self-admin2.52.53.61.9-0.6-1.9
Time to tail flick, test, after self-admin0.10.10.1-0.30.10.4
Delta time to tail flick, vehicle, before/after SA0.30.30.50.70.7-0.1
Delta time to tail flick, test, before/after SA4.54.05.8-2.31.02.4
Ambulatory time before self-admin0.20.20.3-0.20.50.5
Ambulatory time after self-admin0.20.20.20.5-0.4-0.4
Total heroin consumption3.23.87.5-0.32.72.0
Area under the delay curve0.91.01.81.4-0.3-1.0
Delay disc. indifference point, 0s delay1.71.92.61.6-0.7-1.6
Delay disc. indifference point, 16s delay1.11.11.21.0-1.1-1.1
Delay disc. indifference point, 2s delay0.10.20.20.4-0.3-0.5
Delay disc. indifference point, 24s delay0.00.00.10.0-0.3-0.2
Delay disc. indifference point, 4s delay0.80.81.31.1-0.3-1.0
Delay disc. indifference point, 8s delay0.50.61.11.0-0.2-0.8
Delay discount exponential model param0.70.71.3-1.20.20.9
Delay discount hyperbolic model param0.50.61.1-1.10.20.8
Fecal boli incidents, locomotor time 10.10.10.2-0.5-0.00.5
Change in fecal boli incidents, locomotor task0.40.40.80.90.1-0.6
Time >=10cm from walls, locomotor time 11.81.82.51.4-0.9-1.6
Bouts of movement, locomotor time 11.01.11.7-0.41.11.3
Total resting periods, locomotor time 10.60.61.0-0.20.91.0
Rest time, locomotor task time 10.80.91.9-0.8-1.4-0.3
Distance moved, locomotor task time 10.50.61.41.20.4-0.5
Vertical activity count, locomotor time 10.60.61.30.1-1.2-0.7
Time >=10cm from walls, locomotor time 20.00.00.00.1-0.1-0.0
Bouts of movement, locomotor time 20.30.30.60.10.80.5
Total resting periods, locomotor time 20.10.10.30.40.50.2
Rest time, locomotor task time 21.61.83.60.3-1.9-1.3
Distance moved, locomotor task time 20.91.01.7-0.41.31.1
Vertical activity count, locomotor time 21.01.12.0-1.40.11.1
Weight adjusted by age1.51.72.7-0.61.71.4
Seeking ratio, delayed vs. immediate footshock0.40.51.01.0-0.1-0.7
Locomotion in novel chamber2.63.27.2-0.3-2.7-1.6
Locomotion in novel chamber post-restriction1.61.94.10.0-2.0-1.3
Progressive ratio1.82.14.12.01.5-0.4
Food seeking constrained by brief footshock0.20.20.3-0.10.60.5
Seeking ratio, punishment vs. effort1.01.22.0-1.4-1.30.1
Run reversals in cocaine runway, females1.41.42.81.70.8-0.9
Run reversals in cocaine runway, males1.51.53.5-1.9-0.40.9
Latency to leave start box in cocaine runway0.60.61.11.1-0.1-0.8
Latency to leave start box in cocaine runway, F0.30.30.60.80.0-0.5
Latency to leave start box in cocaine runway, M0.00.00.00.10.0-0.1
Cd content in liver0.91.02.2-0.8-1.5-0.1
Co content in liver0.70.81.5-1.0-1.20.0
Cu content in liver0.10.20.30.40.60.1
Fe content in liver0.30.40.8-0.50.40.9
K content in liver1.31.32.11.31.5-0.2
Mg content in liver2.22.35.02.20.4-1.3
Mn content in liver1.61.93.8-0.21.91.4
Na content in liver1.21.31.6-1.11.11.3
Rb content in liver2.02.53.01.6-1.4-1.7
Se content in liver0.10.10.30.6-0.1-0.2
Sr content in liver3.73.44.8-1.51.82.2
Zn content in liver0.60.71.40.31.20.7