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Delay discounting total patch changes 18 sec

Delay discounting using a sequential patch depletion procedure, total patch (feeder) changes in the last two sessions with an experimenter-imposed delay of 18 sec [n]

Tags: Behavior · Delay discounting

Project: p50_david_dietz

41 significantly associated models · 6 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	5	152510403	154082317	4	2	9.5e-08	7.9e-08	1	100	Padi2 Sdhb
2	7	16845355	16970279	1	1	9.4e-82	NaN	NA	NA	NA
3	10	46789397	48185455	1	1	7.7e-15	2.0e-01	1	100	Trim16

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
BMI without tail	106.7	1	1	25	0.00	1.0e+00	NA
Body weight	7.7	1	1	25	0.00	1.0e+00	NA
Epididymis fat weight	87.6	1	1	25	0.00	1.0e+00	NA
Heart weight	9.8	3	0	0	0.00	1.0e+00	Trim16 Sdhb NA
Left kidney weight	37.5	1	1	25	0.00	1.0e+00	NA
Right kidney weight	41.9	1	1	25	0.00	1.0e+00	NA
Tail length	58.1	1	1	25	0.00	1.0e+00	NA
Length with tail	4.0	1	0	0	0.00	1.0e+00	NA
Length without tail	71.1	1	1	25	0.00	1.0e+00	NA
Liver weight, left	15.7	2	1	25	0.00	1.0e+00	Trim16 NA
Liver weight, right	9.6	1	0	0	0.00	1.0e+00	NA
Parametrial fat weight	26.4	1	1	25	0.00	1.0e+00	NA
Retroperitoneal fat weight	4.2	1	0	0	0.00	1.0e+00	NA
Intraocular pressure	25.6	2	2	50	0.00	1.0e+00	Trim16 NA
Extensor digitorum longus weight	25.8	1	1	25	0.00	1.0e+00	NA
Soleus weight	13.7	1	1	25	0.00	1.0e+00	NA
Tibialis anterior weight	59.9	1	1	25	0.00	1.0e+00	NA
Tibia length	7.4	1	0	0	0.00	1.0e+00	NA
Number of licking bursts	109.8	2	1	25	0.00	1.0e+00	Trim16 NA
Food consumed during 24 hour testing period	18.0	2	0	0	0.00	1.0e+00	Trim16 NA
Times rat made contact with spout	55.6	2	1	25	0.00	1.0e+00	Trim16 NA
Mean time between licks in bursts	54.9	1	1	25	0.00	1.0e+00	NA
Mean num. licks in bursts	124.8	2	2	50	0.00	1.0e+00	Trim16 NA
Std. dev. time between licks in bursts	177.7	1	1	25	0.00	1.0e+00	NA
Water consumed over 24 hours	23.8	1	1	25	0.00	1.0e+00	Trim16
Indifference point 0 sec	9.0	4	1	25	0.95	9.2e-06	Trim16 Padi2 Sdhb NA
Indifference point AUC	42.1	1	1	25	0.00	1.0e+00	NA
Delay discounting total patch changes 0 sec	12.6	3	1	25	0.95	4.7e-02	Trim16 Sdhb NA
Delay discounting total patch changes 12 sec	14.2	5	1	25	1.00	5.2e-49	Padi2 Sdhb Crocc Necap2 NA
Delay discounting total patch changes 24 sec	10.7	4	1	25	0.97	9.6e-26	Padi2 Sdhb Crocc NA
Delay discounting total patch changes 6 sec	13.6	5	1	25	1.00	7.0e-46	Padi2 Sdhb Crocc Necap2 NA
Delay discounting water rate 0 sec	13.4	2	0	0	0.00	1.0e+00	Trim16 NA
Delay discounting water rate 12 sec	26.1	1	1	25	0.00	1.0e+00	NA
Delay discounting water rate 18 sec	10.5	1	0	0	0.00	1.0e+00	NA
Delay discounting water rate 24 sec	62.7	1	1	25	0.00	1.0e+00	NA
Delay discounting water rate 6 sec	31.9	2	1	25	0.00	1.0e+00	Trim16 NA
Locomotor testing distance	11.5	1	0	0	0.00	1.0e+00	NA
Locomotor testing rearing	16.8	1	1	25	0.00	1.0e+00	NA
Light reinforcement 1	54.8	1	1	25	0.00	1.0e+00	NA
Reaction time number correct	8.5	2	0	0	0.00	1.0e+00	Trim16 NA
Reaction time num false alarms	56.4	1	1	25	0.00	1.0e+00	NA
Reaction time num false alarms AUC	79.5	1	1	25	0.00	1.0e+00	NA
Reaction time trials correct on left	8.5	2	0	0	0.00	1.0e+00	Trim16 NA
Reaction time trials on left	10.3	1	0	0	0.00	1.0e+00	NA
Reaction time mean	41.3	1	1	25	0.00	1.0e+00	NA
Reaction time mean AUC	58.0	1	1	25	0.00	1.0e+00	NA
Median of all reaction times	51.2	1	1	25	0.00	1.0e+00	NA
Reaction time false alarm rate	63.4	1	1	25	0.00	1.0e+00	NA
Reaction time premature initiation rate	32.1	1	1	25	0.00	1.0e+00	NA
Reaction time premature initiations	34.3	1	1	25	0.00	1.0e+00	NA
Std. dev. reaction times	17.4	1	1	25	0.00	1.0e+00	NA
Reaction time trials completed	10.3	1	0	0	0.00	1.0e+00	NA
Reaction time trials AUC	15.6	1	0	0	0.00	1.0e+00	NA
Social responses	74.3	1	1	25	0.00	1.0e+00	NA
Social time	25.9	1	1	25	0.00	1.0e+00	Trim16
Cocaine response after cond. corrected	56.8	2	1	25	0.00	1.0e+00	Trim16 NA
Cocaine response after cond. not corrected	73.5	2	1	25	0.00	1.0e+00	Trim16 NA
Cocaine response before conditioning	28.6	1	1	25	0.00	1.0e+00	NA
Saline control response	30.3	1	1	25	0.00	1.0e+00	NA
Condit. Reinf. active minus inactive responses	29.4	1	1	25	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	40.7	1	1	25	0.00	1.0e+00	NA
Condit. Reinf. active responses	11.1	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. inactive responses	20.6	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. lever latency	36.3	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	104.9	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. change in total contacts	130.1	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. index score	62.2	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. latency score	67.1	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. lever contacts	29.4	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	150.0	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. intertrial magazine entries	63.9	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. lever-magazine prob. diff.	55.1	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. response bias	30.8	1	1	25	0.00	1.0e+00	NA
Conditioned reinforcement - actives	18.5	1	0	0	0.00	1.0e+00	NA
Conditioned locomotion	9.9	1	0	0	0.00	1.0e+00	NA
Intermittent access intake day 1-15 change	61.5	1	1	25	0.00	1.0e+00	NA
Intermittent access intake escalation	82.5	1	1	25	0.00	1.0e+00	NA
Intermittent access intake escalation 2	42.5	1	1	25	0.00	1.0e+00	NA
Intermitt. access day 1 inactive lever presses	33.6	2	2	50	0.00	1.0e+00	Trim16 NA
Intermitt. access escalation Index	27.6	1	0	0	0.00	1.0e+00	Trim16
Intermittent access day 1 total infusions	32.7	1	1	25	0.00	1.0e+00	NA
Intermittent access day 1 locomotion	20.0	2	1	25	0.00	1.0e+00	Trim16 NA
Intermittent access total locomotion	9.9	1	0	0	0.00	1.0e+00	Trim16
Cocaine induced anxiety	31.7	1	1	25	0.00	1.0e+00	Trim16
Post-drug Anxiety	15.6	2	0	0	0.00	1.0e+00	Trim16 NA
Baseline Anxiety	29.9	1	1	25	0.00	1.0e+00	Trim16
Progressive ratio test 1 active lever presses	11.8	1	0	0	0.00	1.0e+00	NA
Progressive ratio test 1 breakpoint	10.4	1	0	0	0.00	1.0e+00	NA
Progressive ratio test 1 inactive lever presses	10.7	2	0	0	0.00	1.0e+00	Trim16 NA
Progressive ratio test 2 active lever presses	12.2	1	0	0	0.00	1.0e+00	NA
Progressive ratio test 2 breakpoint	38.7	1	1	25	0.00	1.0e+00	NA
Total sessions with >9 infusions	13.7	1	0	0	0.00	1.0e+00	Trim16
Short access day 1 total inactive lever presses	13.8	1	0	0	0.00	1.0e+00	Trim16
Short access day 10 total inactive lever presses	12.2	1	0	0	0.00	1.0e+00	NA
Short access day 1 total infusions	62.7	1	1	25	0.00	1.0e+00	Trim16
Short access day 10 total infusions	24.0	1	1	25	0.00	1.0e+00	NA
Short access day 1 locomotion	25.2	2	1	25	0.00	1.0e+00	Trim16 NA
Short access day 10 total locomotion	14.3	1	0	0	0.00	1.0e+00	Trim16
Compulsive drug intake	22.8	2	1	25	0.00	1.0e+00	Trim16 NA
One hour access (0.3 mA shock)	10.4	1	0	0	0.00	1.0e+00	NA
Number of responses in last shaping day	25.6	1	1	25	0.00	1.0e+00	Trim16
Context. condit. distance diff. score	149.8	1	1	25	0.00	1.0e+00	NA
Locomotion velocity, session 1	117.8	1	1	25	0.00	1.0e+00	NA
Locomotion distance, session 1	260.5	2	2	50	0.00	1.0e+00	Trim16 NA
Locomotion velocity, session 2	82.2	1	1	25	0.00	1.0e+00	NA
Locomotion distance, session 2	522.5	2	1	25	0.00	1.0e+00	Trim16 NA
Locomotion velocity, session 3	116.1	1	1	25	0.00	1.0e+00	NA
Locomotion distance, session 3	82.4	1	1	25	0.00	1.0e+00	NA
Stereotopy head waving bouts, day 3	8.8	1	0	0	0.00	1.0e+00	NA
Stereotopy head waving duration, day 3	25.6	1	1	25	0.00	1.0e+00	NA
Locomotion velocity, session 7	66.3	1	1	25	0.00	1.0e+00	NA
Locomotion distance, session 7	21.3	1	1	25	0.00	1.0e+00	NA
Stereotopy head waving bouts, day 7	36.9	2	2	50	0.00	1.0e+00	Trim16 NA
Stereotopy head waving duration, day 7	63.4	1	1	25	0.00	1.0e+00	NA
Locomotion distance, session 8	102.8	1	1	25	0.00	1.0e+00	NA
Degree of sensitization distance	140.6	1	1	25	0.00	1.0e+00	NA
Degree of sensitization stereotypy	37.5	1	1	25	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	65.1	1	1	25	0.00	1.0e+00	NA
Condit. Reinf. active responses	20.0	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. inactive responses	17.2	1	0	0	0.00	1.0e+00	NA
Incentive salience index mean	15.6	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. lever presses	35.1	1	1	25	0.00	1.0e+00	NA
Time in familiar zone, hab. session 1	16.4	1	0	0	0.00	1.0e+00	NA
Time in novel zone, hab. session 1	17.4	1	0	0	0.00	1.0e+00	NA
Total zone transitions, hab. session 1	289.5	2	2	50	0.00	1.0e+00	Trim16 NA
Total locomotion distance, hab. session 1	127.1	2	2	50	0.00	1.0e+00	Trim16 NA
Locomotion velocity, hab. session 1	155.8	2	2	50	0.00	1.0e+00	Trim16 NA
Time in familiar zone, hab. session 2	48.9	1	1	25	0.00	1.0e+00	NA
Time in novel zone, hab. session 2	58.4	1	1	25	0.00	1.0e+00	NA
Total zone transitions, hab. session 2	256.1	1	1	25	0.00	1.0e+00	NA
Total locomotion distance, hab. session 2	92.5	2	1	25	0.00	1.0e+00	Trim16 NA
Locomotion velocity, hab. session 2	96.3	2	1	25	0.00	1.0e+00	Trim16 NA
Total zone transitions, NPP test	228.8	1	1	25	0.00	1.0e+00	NA
Total locomotion distance, NPP test	163.4	1	1	25	0.00	1.0e+00	NA
Locomotion velocity, NPP test	195.9	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. lever latency	9.3	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	47.9	2	2	50	0.00	1.0e+00	Trim16 NA
Pavlov. Cond. change in total contacts	40.1	1	1	25	0.00	1.0e+00	NA
Pavlov. Cond. index score	31.3	2	1	25	0.00	1.0e+00	Trim16 NA
Pavlov. Cond. latency score	16.6	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. lever contacts	13.3	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	44.8	2	2	50	0.00	1.0e+00	Trim16 NA
Pavlov. Cond. intertrial magazine entries	14.4	1	0	0	0.00	1.0e+00	Trim16
Pavlov. Cond. lever-magazine prob. diff.	37.1	2	1	25	0.00	1.0e+00	Trim16 NA
Pavlov. Cond. response bias	52.4	1	1	25	0.00	1.0e+00	NA
Bone: apparent density	31.2	1	1	25	0.00	1.0e+00	NA
Bone surface	28.9	1	1	25	0.00	1.0e+00	NA
Bone volume	32.3	1	1	25	0.00	1.0e+00	NA
Bone: connectivity density	8.5	1	0	0	0.00	1.0e+00	NA
Bone: cortical apparent density	18.1	1	0	0	0.00	1.0e+00	Trim16
Bone: cortical porosity	80.0	2	1	25	0.00	1.0e+00	Trim16 NA
Bone: cortical porosity	69.9	2	2	50	0.00	1.0e+00	Trim16 NA
Bone: cortical thickness	7.1	4	0	0	0.06	9.2e-01	Padi2 Sdhb Necap2 NA
Bone: cortical thickness	17.9	1	0	0	0.00	1.0e+00	NA
Bone: cortical tissue density	19.6	1	0	0	0.00	1.0e+00	Trim16
Bone: elastic displacement	28.2	1	1	25	0.00	1.0e+00	NA
Bone: endosteal estimation	12.7	1	1	25	0.00	1.0e+00	NA
Bone: final force	39.5	1	1	25	0.00	1.0e+00	NA
Bone: final moment	31.9	1	1	25	0.00	1.0e+00	NA
Bone: marrow area	10.6	1	1	25	0.00	1.0e+00	NA
Bone: maximum force	42.0	1	1	25	0.00	1.0e+00	NA
Bone: maximum moment	29.5	1	1	25	0.00	1.0e+00	NA
Bone: minimum diameter	57.3	1	1	25	0.00	1.0e+00	NA
Bone: periosteal estimation	7.8	1	0	0	0.00	1.0e+00	NA
Bone: periosteal perimeter	8.8	1	0	0	0.00	1.0e+00	NA
Bone: post-yield work	60.6	2	1	25	0.00	1.0e+00	Trim16 NA
Bone: stiffness	90.4	1	1	25	0.00	1.0e+00	NA
Bone: tissue strength	81.0	1	1	25	0.00	1.0e+00	NA
Bone: trabecular number	39.4	1	1	25	0.00	1.0e+00	NA
Bone: trabecular thickness	13.8	1	0	0	0.00	1.0e+00	NA
Bone: trabecular tissue density	43.1	1	1	25	0.00	1.0e+00	NA
Distance traveled before self-admin	12.6	1	0	0	0.00	1.0e+00	NA
Delta time in open arm before/after self-admin	40.2	1	1	25	0.00	1.0e+00	NA
Extinction: sum of active levers before priming	12.2	1	0	0	0.00	1.0e+00	NA
Delta distance traveled before/after self-admin	11.3	1	0	0	0.00	1.0e+00	NA
Time in closed arm before self-admin	50.0	1	1	25	0.00	1.0e+00	NA
Time in closed arm after self-admin	25.8	1	1	25	0.00	1.0e+00	NA
Time in open arm after self-admin	31.3	1	1	25	0.00	1.0e+00	NA
Delta time to tail flick, test, before/after SA	20.0	1	0	0	0.00	1.0e+00	NA
Fecal boli incidents, locomotor time 1	11.8	1	0	0	0.00	1.0e+00	NA
Time >=10cm from walls, locomotor time 1	19.5	1	0	0	0.00	1.0e+00	NA
Time >=10cm from walls, locomotor time 2	19.4	1	1	25	0.00	1.0e+00	NA
Distance moved, locomotor task time 2	13.1	1	0	0	0.00	1.0e+00	NA
Weight adjusted by age	25.0	1	1	25	0.00	1.0e+00	NA
Locomotion in novel chamber	10.2	1	0	0	0.00	1.0e+00	NA
Run reversals in cocaine runway, females	11.6	1	0	0	0.00	1.0e+00	Trim16
Run reversals in cocaine runway, males	25.4	1	1	25	0.00	1.0e+00	NA
Latency to leave start box in cocaine runway	14.8	2	0	0	0.00	1.0e+00	Trim16 NA
Cd content in liver	140.5	1	1	25	0.00	1.0e+00	NA
Co content in liver	83.2	1	1	25	0.00	1.0e+00	NA
Fe content in liver	10.3	1	0	0	0.00	1.0e+00	NA
K content in liver	62.6	1	1	25	0.00	1.0e+00	NA
Mg content in liver	28.9	1	1	25	0.00	1.0e+00	Trim16
Mn content in liver	130.2	1	1	25	0.00	1.0e+00	NA
Rb content in liver	28.1	2	2	50	0.00	1.0e+00	Trim16 NA
Se content in liver	33.4	2	1	25	0.00	1.0e+00	Trim16 NA
Zn content in liver	46.0	1	1	25	0.00	1.0e+00	NA

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	0	0.000	1.3
Adipose	alternative TSS	0	0.000	1.3
Adipose	gene expression	0	0.000	1.3
Adipose	isoform ratio	1	0.035	1.4
Adipose	intron excision ratio	0	0.000	1.6
Adipose	mRNA stability	0	0.000	1.3
BLA	alternative polyA	3	0.250	1.5
BLA	alternative TSS	0	0.000	1.3
BLA	gene expression	0	0.000	1.3
BLA	isoform ratio	0	0.000	1.5
BLA	intron excision ratio	0	0.000	1.3
BLA	mRNA stability	0	0.000	1.3
Brain	alternative polyA	4	0.199	1.4
Brain	alternative TSS	0	0.000	1.3
Brain	gene expression	0	0.000	1.3
Brain	isoform ratio	1	0.032	1.3
Brain	intron excision ratio	0	0.000	1.3
Brain	mRNA stability	0	0.000	1.2
Eye	alternative polyA	0	0.000	2.0
Eye	alternative TSS	0	0.000	1.6
Eye	gene expression	0	0.000	1.3
Eye	isoform ratio	0	0.000	1.4
Eye	intron excision ratio	0	0.000	1.3
Eye	mRNA stability	0	0.000	1.4
IL	alternative polyA	4	0.657	1.4
IL	alternative TSS	0	0.000	1.4
IL	gene expression	0	0.000	1.3
IL	isoform ratio	1	0.127	1.4
IL	intron excision ratio	0	0.000	1.2
IL	mRNA stability	0	0.000	1.3
LHb	alternative polyA	1	0.174	1.4
LHb	alternative TSS	0	0.000	1.6
LHb	gene expression	0	0.000	1.3
LHb	isoform ratio	0	0.000	1.4
LHb	intron excision ratio	0	0.000	1.2
LHb	mRNA stability	0	0.000	1.2
Liver	alternative polyA	1	0.067	1.5
Liver	alternative TSS	0	0.000	1.3
Liver	gene expression	1	0.014	1.3
Liver	isoform ratio	1	0.042	1.4
Liver	intron excision ratio	0	0.000	1.4
Liver	mRNA stability	1	0.041	1.2
NAcc	alternative polyA	4	0.305	1.4
NAcc	alternative TSS	0	0.000	1.2
NAcc	gene expression	1	0.016	1.3
NAcc	isoform ratio	1	0.053	1.4
NAcc	intron excision ratio	0	0.000	1.3
NAcc	mRNA stability	0	0.000	1.3
OFC	alternative polyA	4	0.685	1.5
OFC	alternative TSS	0	0.000	1.5
OFC	gene expression	1	0.027	1.2
OFC	isoform ratio	2	0.245	1.3
OFC	intron excision ratio	0	0.000	1.3
OFC	mRNA stability	0	0.000	1.3
PL	alternative polyA	1	0.070	1.4
PL	alternative TSS	0	0.000	1.3
PL	gene expression	2	0.027	1.3
PL	isoform ratio	4	0.181	1.6
PL	intron excision ratio	0	0.000	1.4
PL	mRNA stability	2	0.069	1.3

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.