Hub : Genes

Ormdl3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000030445	0.35	0.11	0.0e+00	0.22	0.08	0.24	0.17	5.1e-24	2.9e-09	5.4e-27	9.8e-19
2	Brain	gene expression	ENSRNOG00000030445	0.04	0.03	2.3e-03	0.02	0.02	0.01	0.01	8.1e-03	8.4e-03	1.5e-02	1.9e-02
3	Liver	gene expression	ENSRNOG00000030445	0.05	0.04	1.3e-03	0	0.03	0	0.01	8.2e-02	1.3e-04	1.1e-01	7.8e-03
4	Liver	mRNA stability	ENSRNOG00000030445	0.18	0.08	0.0e+00	0.22	0.12	0.19	-0	1.4e-24	4.5e-13	3.0e-20	5.1e-01
5	PL	gene expression	ENSRNOG00000030445	0.15	0.1	7.7e-08	0.09	0.1	0.09	0.09	4.2e-07	1.1e-07	2.7e-07	3.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	3.1	10.2	12.1	-2.9	-3.2	-2.9	3.5	-3.5
BMI without tail	0.1	0.2	0.4	-0.2	-0.4	-0.2	0.5	-0.6
Body weight	5.7	24.0	31.0	-4.1	-5.1	-4.3	5.3	-5.6
Epididymis fat weight	0.2	0.5	0.9	-0.9	-0.6	-0.8	0.4	-0.7
Glucose	0.1	0.2	0.5	-0.7	-0.1	-0.5	0.1	0.2
Heart weight	2.4	3.4	5.5	-1.3	-1.9	-1.3	2.3	-2.1
Left kidney weight	0.3	1.0	1.9	0.1	-1.0	-0.2	1.4	-1.4
Right kidney weight	0.2	0.7	1.0	-0.8	-0.5	-0.8	0.9	-1.0
Tail length	0.0	0.1	0.2	0.5	-0.4	0.2	0.1	-0.4
Length with tail	1.6	5.7	9.1	-1.3	-2.7	-1.7	2.7	-3.0
Length without tail	3.9	8.6	10.5	-2.6	-3.0	-2.7	3.1	-3.2
Liver weight, left	0.0	0.0	0.1	0.1	0.1	0.0	-0.3	0.2
Liver weight, right	0.3	0.6	1.1	0.4	1.0	0.5	-0.8	0.8
Parametrial fat weight	0.5	1.0	2.0	-0.1	1.3	0.3	-1.4	1.2
Retroperitoneal fat weight	0.1	0.3	0.6	-0.7	-0.2	-0.4	0.7	-0.5
Intraocular pressure	1.8	2.5	3.5	-1.0	-1.8	-1.2	1.9	-1.8
Extensor digitorum longus weight	5.4	21.7	31.7	-2.3	-5.5	-3.3	5.6	-5.5
Soleus weight	0.8	2.3	3.7	-1.9	-1.1	-1.9	1.3	-1.2
Tibialis anterior weight	1.7	5.8	7.4	-1.9	-2.5	-2.2	2.7	-2.6
Tibia length	3.1	8.8	9.2	-2.9	-3.0	-2.9	3.0	-2.9
Number of licking bursts	0.3	0.4	1.0	-1.0	-0.2	-0.8	0.1	-0.3
Food consumed during 24 hour testing period	0.7	0.9	1.1	-0.7	-1.1	-0.8	1.0	-1.0
Times rat made contact with spout	0.2	0.2	0.5	-0.2	0.7	0.2	-0.5	0.6
Mean time between licks in bursts	1.2	1.6	1.9	-1.0	-1.4	-1.1	1.4	-1.4
Mean num. licks in bursts	0.4	0.5	0.7	0.8	0.7	0.9	-0.5	0.7
Std. dev. time between licks in bursts	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4	-0.5
Water consumed over 24 hours	0.2	0.2	0.3	-0.5	-0.4	-0.4	0.5	-0.4
Indifference point 0 sec	2.8	4.5	5.1	2.0	2.3	2.1	-2.1	2.2
Indifference point AUC	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.2	-0.2
Indifference point function ln k	0.4	0.6	1.2	1.1	0.3	1.1	-0.5	0.4
Indifference point function log k	0.4	0.6	1.2	1.1	0.3	1.1	-0.5	0.4
Delay discounting total patch changes 0 sec	2.2	3.5	4.0	1.8	2.0	1.9	-1.8	1.8
Delay discounting total patch changes 12 sec	2.9	3.8	5.9	0.8	2.4	1.2	-2.4	2.3
Delay discounting total patch changes 18 sec	0.5	0.7	1.1	0.7	1.0	0.7	-0.9	0.9
Delay discounting total patch changes 24 sec	1.1	1.3	1.9	1.0	1.2	0.9	-1.4	1.3
Delay discounting total patch changes 6 sec	1.9	2.9	4.4	1.2	2.1	1.4	-1.8	1.9
Delay discounting time to switch 0 sec	0.0	0.1	0.3	-0.0	0.5	-0.0	-0.1	0.2
Delay discounting water rate 0 sec	0.1	0.1	0.2	0.4	0.1	0.5	-0.5	0.3
Delay discounting water rate 12 sec	0.0	0.0	0.1	0.3	-0.1	0.2	-0.1	0.0
Delay discounting water rate 18 sec	0.1	0.1	0.3	-0.2	0.2	0.1	-0.5	0.4
Delay discounting water rate 24 sec	0.4	0.5	0.7	0.3	0.7	0.7	-0.9	0.9
Delay discounting water rate 6 sec	1.1	1.5	2.8	0.7	1.2	1.0	-1.7	1.4
Locomotor activity	0.1	0.2	0.6	-0.8	0.1	-0.6	-0.4	0.1
Locomotor testing distance	1.0	1.7	3.1	0.6	1.4	0.8	-1.8	1.5
Locomotor testing rearing	6.7	10.6	13.7	2.6	3.7	2.9	-3.5	3.5
Light reinforcement 1	2.2	4.0	5.7	1.3	2.4	1.6	-2.4	2.1
Light reinforcement 2	0.1	0.2	0.5	-0.7	0.4	-0.3	-0.2	0.2
Reaction time number correct	1.2	1.7	2.1	-1.4	-1.5	-1.3	1.2	-1.1
Reaction time mean minus median	0.2	0.2	0.5	0.1	-0.7	-0.2	0.4	-0.6
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	-0.4	-0.1	-0.0	-0.1
Reaction time num false alarms	0.1	0.2	0.4	-0.6	0.3	-0.6	-0.2	0.2
Reaction time num false alarms AUC	0.1	0.2	0.5	-0.7	0.1	-0.7	-0.1	0.1
Reaction time trials correct on left	1.2	1.7	2.1	-1.4	-1.5	-1.3	1.2	-1.1
Reaction time trials on left	1.2	1.7	2.0	-1.4	-1.4	-1.3	1.2	-1.0
Reaction time mean	0.9	1.3	2.1	1.4	0.8	1.3	-1.1	0.9
Reaction time mean AUC	1.0	1.3	2.2	1.5	0.8	1.3	-1.1	0.8
Median of all reaction times	2.0	2.7	3.1	1.8	1.5	1.7	-1.7	1.5
Reaction time omissions	0.5	0.7	1.2	0.4	1.0	0.6	-1.1	1.0
Reaction time false alarm rate	0.2	0.3	0.6	0.0	0.8	0.0	-0.7	0.6
Reaction time premature initiation rate	0.1	0.2	0.6	0.0	0.3	0.2	-0.8	0.4
Reaction time premature initiations	0.2	0.3	0.5	-0.7	-0.7	-0.5	0.1	-0.4
Std. dev. reaction times	0.0	0.0	0.1	0.4	-0.1	0.1	-0.2	-0.0
Reaction time trials completed	1.2	1.7	2.0	-1.4	-1.4	-1.3	1.2	-1.0
Reaction time trials AUC	0.9	1.3	1.7	-1.2	-1.3	-1.1	1.1	-0.9
Social response proportion	0.3	0.4	0.8	-0.5	-0.5	-0.5	0.9	-0.6
Social responses	0.2	0.3	0.7	-0.9	-0.3	-0.7	0.4	-0.3
Social time	1.5	2.0	3.3	-1.8	-1.2	-1.7	1.1	-1.1
Conditioned locomotion	0.4	0.5	0.8	0.9	0.6	0.7	-0.7	0.6
Cocaine response after cond. corrected	0.4	0.5	1.3	-1.1	-0.1	-1.0	0.0	0.1
Cocaine response after cond. not corrected	0.4	0.5	1.4	-1.2	-0.0	-1.0	-0.1	0.3
Cocaine response before conditioning	0.2	0.2	0.3	0.4	0.4	0.5	-0.5	0.6
Saline control response	0.8	1.0	1.5	-1.2	-0.9	-1.2	0.9	-0.8
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.2	1.0	0.3	-1.1	1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.2	0.6	-0.0	-0.7	0.6
Condit. Reinf. active responses	0.6	0.8	1.5	-0.1	1.2	0.2	-1.2	1.1
Condit. Reinf. inactive responses	0.7	0.8	1.5	-0.1	1.2	0.2	-1.2	1.2
Condit. Reinf. lever presses	0.2	0.2	0.4	0.4	0.5	0.5	-0.6	0.5
Condit. Reinf. lever reinforcers received	0.8	1.2	2.1	0.2	1.4	0.5	-1.4	1.3
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.1	-0.4	-0.2	0.6	-0.5
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	-0.7	-0.8	-0.6	0.2	-0.4
Pavlov. Cond. change in total contacts	0.8	1.1	1.5	0.6	1.1	0.9	-1.2	1.2
Pavlov. Cond. index score	0.1	0.1	0.3	-0.5	-0.0	-0.2	-0.3	0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.6	-0.2	-0.3	-0.1	0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.4	0.4	-0.0	-0.7	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.5	0.3	0.3	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	1.0	-0.3	0.6	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.5	-0.2	-0.3	-0.2	0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.3	0.6	0.1	-1.0	0.8
Conditioned reinforcement - actives	0.6	0.6	1.0	0.4	0.8	0.5	-1.0	1.0
Conditioned reinforcement - inactives	2.3	2.6	3.7	1.3	1.8	1.5	-1.5	1.9
Conditioned locomotion	0.2	0.3	0.6	-0.1	0.6	0.1	-0.8	0.6
Intermittent access intake day 1-15 change	0.6	0.6	0.9	0.8	0.4	0.8	-0.9	0.7
Intermittent access intake escalation	0.5	0.5	0.8	0.7	0.4	0.7	-0.9	0.7
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.0	-0.4	-0.0	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	1.4	1.6	2.2	0.8	1.5	1.1	-1.5	1.3
Intermitt. access day 15 inactive lever presses	4.1	4.5	6.2	1.6	2.2	1.9	-2.5	2.3
Intermitt. access escalation Index	1.9	1.7	2.3	-0.9	-1.5	-1.0	1.5	-1.5
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.3	0.6	-0.0	-0.4	0.5
Intermittent access day 15 total infusions	0.7	0.8	1.1	0.7	0.8	0.8	-1.0	1.0
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.0	0.5	0.8	0.6	-0.9	1.0
Intermittent access total infusions	0.2	0.2	0.4	0.2	0.5	0.3	-0.5	0.6
Intermittent access day 1 locomotion	0.3	0.3	0.9	0.2	0.9	0.4	-0.5	0.7
Intermittent access day 15 total locomotion	0.2	0.2	0.4	0.0	0.6	0.3	-0.6	0.6
Intermittent access total locomotion	1.0	1.1	1.4	0.8	1.2	0.9	-1.2	1.1
Intermittent access standard deviation	2.8	2.9	3.6	1.7	1.6	1.6	-1.9	1.7
Cocaine induced anxiety	3.8	4.3	5.3	-2.1	-2.0	-2.0	1.9	-2.3
Post-drug Anxiety	0.6	0.7	1.0	-1.0	-0.8	-0.9	0.7	-0.8
Baseline Anxiety	2.4	2.5	3.4	1.6	1.5	1.6	-1.5	1.8
Lifetime Intake	0.3	0.3	0.5	0.3	0.6	0.4	-0.7	0.7
Incentive Sensitization - Responses	1.0	1.0	1.9	0.5	1.1	0.7	-1.2	1.4
Incentive Sensitization - Breakpoint	0.9	0.9	1.7	0.3	1.0	0.6	-1.1	1.3
Progressive ratio test 1 active lever presses	0.7	0.7	1.3	0.6	1.1	0.6	-0.7	0.9
Progressive ratio test 1 breakpoint	0.5	0.6	1.1	0.5	1.0	0.6	-0.6	0.8
Progressive ratio test 1 inactive lever presses	2.1	2.3	2.6	1.4	1.6	1.5	-1.5	1.5
Progressive ratio test 2 active lever presses	1.4	1.5	2.3	0.9	1.3	1.0	-1.3	1.5
Progressive ratio test 2 breakpoint	1.0	1.1	1.8	0.8	1.1	0.8	-1.1	1.3
Progressive ratio test 2 inactive lever presses	0.6	0.6	1.0	0.5	0.9	0.6	-0.8	1.0
Total sessions with >9 infusions	1.2	1.4	1.8	1.4	1.1	1.3	-1.0	1.1
Short access day 1 total inactive lever presses	1.9	2.1	3.0	1.0	1.5	1.3	-1.6	1.7
Short access day 10 total inactive lever presses	0.1	0.1	0.4	0.1	-0.6	-0.0	0.2	-0.4
Short access day 1 total infusions	1.3	1.4	1.7	1.1	1.3	1.2	-1.1	1.3
Short access day 10 total infusions	0.2	0.2	0.5	-0.2	0.7	0.0	-0.5	0.6
Short access total infusions	0.7	0.7	0.8	0.8	0.8	0.8	-0.9	0.9
Short access day 1 locomotion	3.8	4.0	4.8	1.6	2.2	1.8	-2.2	2.2
Short access day 10 total locomotion	0.9	1.0	1.8	0.4	1.3	0.5	-1.2	1.1
Short access total locomotion	1.2	1.3	1.5	1.2	1.1	1.2	-1.0	1.1
Compulsive drug intake	0.7	0.7	2.3	1.5	-0.4	1.0	0.1	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.4	0.1	0.3	-0.2	0.3
One hour access (shock baseline)	0.2	0.2	0.3	-0.5	0.6	-0.2	-0.4	0.4
Number of responses in last shaping day	1.6	1.6	2.6	1.6	1.2	1.4	-1.0	1.2
Context. condit. distance diff. score	0.3	0.3	0.6	0.8	-0.6	0.7	0.4	-0.3
Locomotion velocity, session 1	0.9	1.0	1.1	-1.0	-0.8	-1.0	1.1	-1.0
Locomotion distance, session 1	3.6	4.7	5.8	-1.9	-2.2	-2.1	2.2	-2.4
Locomotion velocity, session 2	0.0	0.1	0.1	0.1	-0.2	-0.0	0.3	-0.4
Locomotion distance, session 2	1.0	1.5	2.0	-1.4	-1.0	-1.4	0.9	-1.2
Locomotion velocity, session 3	0.4	0.5	1.0	1.0	0.5	0.9	-0.6	0.4
Locomotion distance, session 3	0.1	0.1	0.3	-0.0	-0.4	-0.2	0.3	-0.5
Stereotopy head waving bouts, day 3	2.7	3.2	4.0	1.5	1.9	1.7	-1.8	2.0
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	0.4	0.4	-0.3	0.4
Locomotion velocity, session 7	1.8	2.0	2.3	-1.3	-1.5	-1.5	1.3	-1.5
Locomotion distance, session 7	0.4	0.6	0.7	-0.7	-0.8	-0.8	0.8	-0.7
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.2	0.4	0.3	-0.5	0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.3	0.4	0.3	-0.4	0.3
Locomotion velocity, session 8	4.4	5.3	7.8	-1.2	-2.8	-1.6	2.7	-2.8
Locomotion distance, session 8	1.1	1.7	2.3	-0.9	-1.5	-1.0	1.4	-1.5
Degree of sensitization distance	0.7	0.7	1.1	-0.7	-0.9	-0.7	1.0	-0.8
Degree of sensitization stereotypy	0.2	0.2	0.3	0.0	0.5	0.1	-0.6	0.5
Condit. Reinf. active minus inactive responses	2.0	2.2	2.6	1.6	1.3	1.6	-1.6	1.4
Condit. Reinf. active-inactive response ratio	3.4	3.7	4.8	2.2	1.7	2.1	-1.8	1.7
Condit. Reinf. active responses	1.5	1.8	2.1	1.3	1.3	1.3	-1.5	1.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.6	-0.0	-0.4	-0.1	0.1
Incentive salience index mean	2.2	2.6	3.3	1.4	1.6	1.5	-1.8	1.7
Condit. Reinf. lever presses	0.5	0.6	1.0	0.3	0.9	0.5	-1.0	1.0
Time in familiar zone, hab. session 1	1.1	1.0	2.9	-1.7	-0.3	-1.3	0.5	-0.3
Time in novel zone, hab. session 1	3.1	3.0	4.7	2.2	1.3	2.1	-1.5	1.4
Total zone transitions, hab. session 1	0.8	1.1	1.8	-0.5	-1.2	-0.6	1.4	-1.3
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.4	0.1	0.5	-0.2	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.1	-0.4	0.1	0.3	-0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.3	0.3
Time in novel zone, hab. session 2	0.7	0.8	1.1	1.0	0.9	0.9	-0.7	0.7
Total zone transitions, hab. session 2	1.1	1.4	1.7	-0.9	-1.3	-1.0	1.3	-1.3
Total locomotion distance, hab. session 2	0.7	0.9	1.1	-1.0	-1.0	-0.9	0.9	-0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.5	-1.1	-1.2	-1.0	1.1	-1.1
Novel to familiar place preference ratio	0.2	0.2	0.3	0.5	-0.5	0.1	0.4	-0.5
Novelty place preference	0.2	0.2	0.8	0.9	-0.2	0.5	0.2	-0.3
Time in novel zone, NPP test	0.3	0.3	0.9	1.0	0.1	0.6	-0.1	0.1
Total zone transitions, NPP test	1.7	2.4	3.3	-1.8	-1.3	-1.7	1.5	-1.4
Total locomotion distance, NPP test	0.5	0.7	1.4	-1.2	-0.6	-0.9	0.8	-0.6
Locomotion velocity, NPP test	0.9	1.3	1.6	-1.2	-1.1	-1.1	1.2	-1.1
Pavlov. Cond. lever latency	0.6	0.7	1.2	0.6	-1.1	0.2	1.0	-1.0
Pavlov. Cond. magazine entry latency	4.5	5.8	9.2	0.8	3.0	1.4	-2.9	3.0
Pavlov. Cond. change in total contacts	8.2	8.8	11.2	2.1	3.3	2.6	-3.2	3.3
Pavlov. Cond. index score	2.8	3.6	6.0	0.2	2.4	0.8	-2.3	2.4
Pavlov. Cond. latency score	1.7	2.2	3.9	-0.1	2.0	0.4	-1.8	1.9
Pavlov. Cond. lever contacts	0.4	0.5	0.7	-0.7	0.8	-0.4	-0.8	0.8
Pavlov. Cond. magazine entry number	6.5	8.1	12.2	-1.2	-3.5	-1.9	3.3	-3.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.2	-0.9	-0.1	0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.6	7.4	0.5	2.7	1.1	-2.6	2.7
Pavlov. Cond. response bias	4.9	6.0	9.0	1.1	3.0	1.7	-2.9	3.0
Bone: apparent density	1.0	1.7	2.7	0.6	1.7	0.9	-1.6	1.5
Bone surface	0.2	0.4	0.8	-0.9	-0.3	-0.8	0.5	-0.5
Bone volume	0.3	0.5	1.4	-1.2	-0.2	-1.0	0.4	-0.4
Bone: connectivity density	2.0	3.2	4.5	1.2	2.1	1.4	-2.1	1.9
Bone: cortical apparent density	7.6	10.0	12.7	2.5	3.4	2.9	-3.3	3.6
Bone: cortical area	0.0	0.0	0.1	-0.1	0.0	0.1	-0.2	0.2
Bone: cortical porosity	0.4	0.4	0.9	-1.0	-0.3	-0.9	0.3	-0.2
Bone: cortical porosity	0.7	0.8	1.7	-1.3	-0.6	-1.2	0.6	-0.4
Bone: cortical thickness	1.2	2.1	2.6	1.3	1.3	1.4	-1.6	1.5
Bone: cortical thickness	5.8	6.8	8.9	2.0	2.7	2.3	-3.0	2.8
Bone: cortical tissue density	7.6	9.9	12.6	2.5	3.4	2.9	-3.3	3.6
Bone: elastic displacement	0.0	0.0	0.1	0.2	0.0	0.3	-0.1	0.1
Bone: elastic work	0.0	0.0	0.2	-0.4	-0.1	-0.2	-0.1	-0.0
Bone: endosteal estimation	3.6	7.7	8.8	-2.7	-2.5	-2.9	3.0	-2.8
Bone: endosteal perimeter	1.6	3.2	4.0	-1.6	-1.8	-1.8	2.0	-1.8
Bone: final force	0.3	0.5	1.4	-1.2	0.0	-0.9	-0.0	0.1
Bone: final moment	0.4	0.6	1.7	-1.3	-0.2	-1.1	0.2	-0.1
Bone: marrow area	3.4	7.3	8.3	-2.6	-2.4	-2.8	2.9	-2.7
Bone: maximum diameter	0.0	0.1	0.2	-0.4	-0.1	-0.4	0.0	-0.0
Bone: maximum force	0.5	0.9	1.6	-1.3	-0.7	-1.1	0.8	-0.7
Bone: maximum moment	0.6	1.1	1.7	-1.3	-0.9	-1.2	1.0	-0.9
Bone: minimum diameter	0.9	1.6	1.7	-1.3	-1.3	-1.2	1.3	-1.2
Bone: periosteal estimation	0.9	1.8	2.5	-1.6	-1.1	-1.5	1.3	-1.2
Bone: periosteal perimeter	1.5	2.6	2.9	-1.7	-1.6	-1.7	1.6	-1.5
Bone: post-yield work	1.2	1.7	2.4	-0.8	-1.5	-0.9	1.5	-1.6
Bone: stiffness	0.2	0.4	0.8	-0.9	-0.4	-0.8	0.5	-0.4
Bone: tissue strength	0.7	0.7	1.2	-0.4	-1.1	-0.5	1.0	-1.0
Bone: trabecular number	2.0	3.1	5.3	0.5	2.3	0.9	-2.2	2.1
Bone: trabecular spacing	3.2	4.1	4.4	-2.1	-2.0	-2.1	2.1	-1.9
Bone: trabecular thickness	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	0.2
Bone: trabecular tissue density	1.4	1.9	3.9	2.0	1.0	1.7	-0.9	1.0
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.4	0.0
Distance traveled before self-admin	0.4	0.4	1.2	-1.1	-0.1	-0.8	0.3	-0.3
Distance traveled after self-admin	1.3	1.4	1.8	-1.2	-1.0	-1.1	1.4	-1.3
Delta time in closed arm before/after self-admin	3.1	3.0	4.4	-1.0	-2.0	-1.3	2.0	-2.1
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.0	0.1	0.0	0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.2	-0.3
Extinction: sum of active levers before priming	2.2	2.2	2.8	-1.2	-1.5	-1.4	1.7	-1.7
Active lever presses in extinction session 6	1.1	1.1	3.2	-1.8	0.4	-1.4	-0.3	-0.0
Delta distance traveled before/after self-admin	0.7	0.7	1.3	-0.0	-1.0	-0.3	1.1	-1.1
Delta ambulatory time before/after self-admin	0.9	1.0	1.8	-0.4	-1.1	-0.7	1.2	-1.3
Time in closed arm before self-admin	2.3	2.7	3.3	1.6	1.8	1.8	-1.3	1.6
Time in closed arm after self-admin	0.6	0.6	1.7	1.3	0.3	1.1	0.1	0.1
Time in open arm before self-admin	1.9	2.0	3.1	-1.0	-1.8	-1.4	1.3	-1.5
Time in open arm after self-admin	0.5	0.6	1.1	-0.7	-1.0	-0.7	0.6	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	0.3	-0.1	-0.3	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.1	-0.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.7	-0.2	-0.6	0.0	-0.3
Time to tail flick, test, before self-admin	1.3	1.3	2.4	-0.6	-1.6	-0.9	1.0	-1.4
Time to tail flick, test, after self-admin	0.4	0.4	1.3	-1.2	0.3	-0.6	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	1.4	-1.2	-0.2	-1.0	0.0	-0.4
Delta time to tail flick, test, before/after SA	1.5	1.3	2.8	-0.1	1.7	0.6	-1.1	1.5
Ambulatory time before self-admin	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.2	-0.1
Ambulatory time after self-admin	2.7	3.0	4.0	-1.6	-1.5	-1.6	1.9	-2.0
Total heroin consumption	0.6	0.7	1.3	-1.1	0.9	-0.5	-1.0	0.7
Area under the delay curve	0.2	0.3	0.4	0.5	0.2	0.5	-0.7	0.5
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	0.5	0.8	0.7	-1.2	1.1
Delay disc. indifference point, 16s delay	1.6	1.7	2.4	1.5	1.1	1.5	-1.0	1.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.5	0.3	-0.2	-0.7	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.5	0.0	0.5	-0.1	0.1
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	0.1	0.3	0.3	-1.0	0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	0.1	0.3	-0.3	0.2
Delay discount exponential model param	0.1	0.1	0.3	-0.4	-0.0	-0.4	0.5	-0.3
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.4	-0.1	-0.4	0.6	-0.4
Fecal boli incidents, locomotor time 1	0.4	0.5	0.6	-0.8	-0.5	-0.7	0.7	-0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.1	0.0
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	1.2	0.8	1.0	-0.7	0.9
Bouts of movement, locomotor time 1	0.5	0.5	1.1	-0.3	-0.6	-0.7	0.7	-1.0
Total resting periods, locomotor time 1	1.2	1.4	2.3	-0.9	-1.0	-1.2	1.2	-1.5
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.4	0.3	-0.4	0.3	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.1	-0.1	0.1	-0.2	0.5
Vertical activity count, locomotor time 1	0.3	0.4	1.2	-0.5	-1.1	-0.5	0.3	-0.2
Time >=10cm from walls, locomotor time 2	0.6	0.7	1.3	0.3	1.0	0.2	-1.0	1.2
Bouts of movement, locomotor time 2	0.9	1.0	1.7	1.3	1.1	1.0	-0.8	0.7
Total resting periods, locomotor time 2	0.9	1.0	1.9	1.4	1.0	1.1	-0.8	0.6
Rest time, locomotor task time 2	0.6	0.7	1.2	-0.6	-0.8	-0.7	0.9	-1.1
Distance moved, locomotor task time 2	0.3	0.3	0.5	-0.6	-0.5	-0.6	0.7	-0.3
Vertical activity count, locomotor time 2	0.4	0.4	1.0	-0.4	-1.0	-0.4	0.7	-0.5
Weight adjusted by age	1.0	1.1	2.0	-1.3	-0.8	-1.4	0.7	-1.0
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	2.9	1.6	1.0	1.7	-1.3	1.4
Locomotion in novel chamber	3.2	4.0	6.5	0.6	2.5	1.1	-2.3	2.6
Locomotion in novel chamber post-restriction	0.3	0.4	1.2	-1.1	0.1	-0.7	-0.5	0.2
Progressive ratio	0.1	0.1	0.3	-0.5	-0.1	-0.5	-0.2	0.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.2	0.1
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.3	0.3	0.3	0.1	0.1
Run reversals in cocaine runway, females	0.8	0.8	1.7	0.6	-1.3	0.3	1.1	-0.7
Run reversals in cocaine runway, males	0.2	0.2	0.6	0.1	0.5	0.3	-0.6	0.7
Latency to leave start box in cocaine runway	0.8	0.8	1.3	-0.6	-1.1	-0.6	1.2	-0.9
Latency to leave start box in cocaine runway, F	1.3	1.4	1.7	-1.1	-1.3	-1.1	1.3	-1.2
Latency to leave start box in cocaine runway, M	1.1	1.0	1.6	1.2	0.9	1.3	-0.7	0.8
Cd content in liver	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	0.2
Co content in liver	0.1	0.1	0.3	0.3	-0.3	0.2	0.5	-0.4
Cu content in liver	0.4	0.4	0.9	0.9	0.5	0.8	-0.5	0.4
Fe content in liver	1.3	1.6	2.0	-1.0	-1.4	-1.2	1.2	-1.4
K content in liver	1.0	1.0	1.7	0.7	1.0	0.7	-1.3	1.1
Mg content in liver	3.4	3.5	4.2	2.1	1.6	1.9	-1.9	1.8
Mn content in liver	3.5	4.0	4.6	1.9	2.0	1.9	-2.2	2.0
Na content in liver	0.5	0.5	1.3	-1.1	-0.3	-1.1	0.2	-0.2
Rb content in liver	1.5	1.8	2.4	1.0	1.5	1.2	-1.4	1.5
Se content in liver	5.5	6.6	8.5	1.8	2.9	2.1	-2.9	2.9
Sr content in liver	0.9	0.8	1.0	1.0	0.8	1.0	-0.8	0.8
Zn content in liver	2.5	2.7	3.8	1.0	1.9	1.3	-1.8	2.0