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Total locomotion distance, hab. session 1

Total distance of locomotion during first habituation session for males and females [meters]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

2 loci · 5 genes with independent associations · 16 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	140610199	142727457	12	2	2.88e-13	2.81e-13	1.00e+00	Ctsc Grm5
2	chr14	30999148	32675802	4	3	6.36e-10	3.40e-14	5.77e-05	LOC108352740 Nmu Pdcl2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Left kidney weight	4.15	2	0	0	0	1.00e+00	LOC108352740 Pdcl2
Liver weight, right	7.14	1	0	0	1	3.51e-03	Grm5
Intraocular pressure	11.89	3	0	0	-0.99	9.71e-22	Ctsc Grm5 LOC102554680
Extensor digitorum longus weight	3.83	2	0	0	0	1.00e+00	Exoc1l Nmu
Mean time between licks in bursts	7.85	3	0	0	1	3.26e-18	Ctsc Grm5 LOC102554680
Patch foraging time to switch 0 sec	8.61	3	0	0	0.99	6.08e-17	Ctsc Grm5 LOC102554680
Patch foraging water rate 0 sec	7.05	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	12.26	3	1	20	-0.99	8.84e-18	Ctsc Grm5 LOC102554680
Patch foraging water rate 18 sec	20.17	3	3	60	-0.99	4.71e-25	Ctsc Grm5 LOC102554680
Patch foraging water rate 24 sec	7.66	2	0	0	-1	3.31e-04	Ctsc Grm5
Patch foraging water rate 6 sec	7.91	2	0	0	-1	9.47e-11	Ctsc Grm5
Light reinforcement 1	11.07	3	0	0	1	4.97e-35	Ctsc Grm5 LOC102554680
Light reinforcement 2	21.26	3	3	60	1	5.96e-37	Ctsc Grm5 LOC102554680
Reaction time num false alarms	12.66	3	0	0	1	1.27e-31	Ctsc Grm5 LOC102554680
Reaction time num false alarms AUC	10.23	3	0	0	1	1.27e-27	Ctsc Grm5 LOC102554680
Reaction time false alarm rate	12.88	3	0	0	1	2.94e-26	Ctsc Grm5 LOC102554680
Short access day 1 total infusions	10.36	2	0	0	1	1.28e-11	Ctsc Grm5
Locomotion velocity, session 1	16.27	3	0	0	-1	6.09e-34	Ctsc Grm5 LOC102554680
Locomotion velocity, session 2	8.84	2	0	0	0	1.00e+00	Ctsc Grm5
Locomotion distance, session 3	10.25	2	0	0	-1	3.90e-09	Ctsc Grm5
Stereotopy head waving bouts, day 3	9.54	3	0	0	1	6.83e-21	Ctsc Grm5 LOC102554680
Stereotopy head waving duration, day 3	11.48	4	0	0	1	3.08e-03	Exoc1l LOC108352740 Nmu Pdcl2
Locomotion velocity, session 8	8.71	2	0	0	-1	3.20e-04	Ctsc Grm5
Total zone transitions, hab. session 1	8.07	3	0	0	-1	2.11e-09	Ctsc Grm5 LOC102554680
Locomotion velocity, hab. session 1	27.81	7	6	120	1	2.03e-43	Ctsc Exoc1l Grm5 LOC102554680 LOC108352740 Nmu Pdcl2
Total locomotion distance, hab. session 2	31.57	7	3	60	0.99	4.85e-28	Ctsc Exoc1l Grm5 LOC102554680 LOC108352740 Nmu Pdcl2
Locomotion velocity, hab. session 2	29.36	7	3	60	0.99	5.31e-28	Ctsc Exoc1l Grm5 LOC102554680 LOC108352740 Nmu Pdcl2
Total locomotion distance, NPP test	36.19	7	4	80	0.99	1.53e-27	Ctsc Exoc1l Grm5 LOC102554680 LOC108352740 Nmu Pdcl2
Locomotion velocity, NPP test	35.01	7	4	80	0.99	1.16e-28	Ctsc Exoc1l Grm5 LOC102554680 LOC108352740 Nmu Pdcl2
Sum of active levers in priming session hrs 5-6	10.8	1	0	0	0	1.00e+00	Grm5
Latency to leave start box in cocaine runway	12.87	1	0	0	1	5.67e-06	Grm5
Na content in liver	10.78	1	0	0	0	1.00e+00	Ctsc

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.43
Adipose	alternative TSS	0	0	1.46
Adipose	gene expression	0	0	1.44
Adipose	isoform ratio	2	0	1.43
Adipose	intron excision ratio	2	0.1	1.44
Adipose	mRNA stability	0	0	1.43
BLA	alternative polyA	0	0	1.39
BLA	alternative TSS	0	0	1.39
BLA	gene expression	2	0	1.43
BLA	isoform ratio	2	0.1	1.44
BLA	intron excision ratio	0	0	1.35
BLA	mRNA stability	0	0	1.44
Brain	alternative polyA	2	0.1	1.45
Brain	alternative TSS	0	0	1.41
Brain	gene expression	1	0	1.44
Brain	isoform ratio	3	0.1	1.42
Brain	intron excision ratio	0	0	1.35
Brain	mRNA stability	2	0	1.43
Eye	alternative polyA	0	0	1.48
Eye	alternative TSS	0	0	1.53
Eye	gene expression	1	0.1	1.42
Eye	isoform ratio	0	0	1.43
Eye	intron excision ratio	0	0	1.37
Eye	mRNA stability	0	0	1.36
IL	alternative polyA	0	0	1.31
IL	alternative TSS	0	0	1.51
IL	gene expression	1	0	1.48
IL	isoform ratio	0	0	1.4
IL	intron excision ratio	0	0	1.33
IL	mRNA stability	0	0	1.43
LHb	alternative polyA	0	0	1.41
LHb	alternative TSS	0	0	1.44
LHb	gene expression	0	0	1.44
LHb	isoform ratio	0	0	1.47
LHb	intron excision ratio	0	0	1.32
LHb	mRNA stability	0	0	1.36
Liver	alternative polyA	0	0	1.45
Liver	alternative TSS	0	0	1.43
Liver	gene expression	1	0	1.41
Liver	isoform ratio	0	0	1.4
Liver	intron excision ratio	0	0	1.42
Liver	mRNA stability	0	0	1.44
NAcc	alternative polyA	0	0	1.47
NAcc	alternative TSS	0	0	1.5
NAcc	gene expression	2	0	1.45
NAcc	isoform ratio	4	0.1	1.42
NAcc	intron excision ratio	0	0	1.42
NAcc	mRNA stability	0	0	1.44
OFC	alternative polyA	0	0	1.51
OFC	alternative TSS	0	0	1.48
OFC	gene expression	2	0	1.47
OFC	isoform ratio	0	0	1.49
OFC	intron excision ratio	0	0	1.34
OFC	mRNA stability	0	0	1.45
PL	alternative polyA	0	0	1.44
PL	alternative TSS	1	0	1.46
PL	gene expression	2	0	1.45
PL	isoform ratio	1	0	1.4
PL	intron excision ratio	0	0	1.37
PL	mRNA stability	0	0	1.42
pVTA	alternative polyA	0	0	1.36
pVTA	alternative TSS	0	0	1.39
pVTA	gene expression	1	0	1.44
pVTA	isoform ratio	0	0	1.43
pVTA	intron excision ratio	0	0	1.32
pVTA	mRNA stability	0	0	1.37
RMTg	alternative polyA	0	0	1.22
RMTg	alternative TSS	0	0	1.3
RMTg	gene expression	0	0	1.39
RMTg	isoform ratio	0	0	1.34
RMTg	intron excision ratio	0	0	1.36
RMTg	mRNA stability	0	0	1.37