Hub : Traits

Reaction time premature initiations

Premature initiations indicated by number of times that the rat pulled its snout out of the center hole before the imperative stimulus occurred and then put its snout back into the center hole without going to the left water feeder in the last three 18-minute sessions for males and females [n]

Tags: Behavior · Reaction time

Project: p50_david_dietz

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	7	16845355	16970279	1	1	3.67e-17	NaN	NA	ENSRNOG00000064438

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	106.71	1	1	100	0	1e+00	ENSRNOG00000064438
Body weight	7.66	1	1	100	0	1e+00	ENSRNOG00000064438
Epididymis fat weight	87.61	1	1	100	0	1e+00	ENSRNOG00000064438
Glucose	5.03	1	0	0	0	1e+00	ENSRNOG00000064438
Heart weight	11.41	1	0	0	0	1e+00	ENSRNOG00000064438
Left kidney weight	37.46	1	1	100	0	1e+00	ENSRNOG00000064438
Right kidney weight	41.88	1	1	100	0	1e+00	ENSRNOG00000064438
Tail length	58.13	1	1	100	0	1e+00	ENSRNOG00000064438
Length with tail	3.24	1	0	0	0	1e+00	ENSRNOG00000064438
Length without tail	71.11	1	1	100	0	1e+00	ENSRNOG00000064438
Liver weight, left	23.57	1	1	100	0	1e+00	ENSRNOG00000064438
Liver weight, right	9.6	1	0	0	0	1e+00	ENSRNOG00000064438
Parametrial fat weight	14.9	1	1	100	0	1e+00	ENSRNOG00000064438
Retroperitoneal fat weight	3.02	1	0	0	0	1e+00	ENSRNOG00000064438
Intraocular pressure	18.97	1	1	100	0	1e+00	ENSRNOG00000064438
Extensor digitorum longus weight	25.81	1	1	100	0	1e+00	ENSRNOG00000064438
Soleus weight	13.71	1	1	100	0	1e+00	ENSRNOG00000064438
Tibialis anterior weight	59.91	1	1	100	0	1e+00	ENSRNOG00000064438
Tibia length	5.35	1	0	0	0	1e+00	ENSRNOG00000064438
Number of licking bursts	155.04	1	1	100	0	1e+00	ENSRNOG00000064438
Food consumed during 24 hour testing period	17.5	1	0	0	0	1e+00	ENSRNOG00000064438
Times rat made contact with spout	75.14	1	1	100	0	1e+00	ENSRNOG00000064438
Mean time between licks in bursts	54.91	1	1	100	0	1e+00	ENSRNOG00000064438
Mean num. licks in bursts	164.17	1	1	100	0	1e+00	ENSRNOG00000064438
Std. dev. time between licks in bursts	177.72	1	1	100	0	1e+00	ENSRNOG00000064438
Water consumed over 24 hours	5.74	1	0	0	0	1e+00	ENSRNOG00000064438
Indifference point 0 sec	18.72	1	1	100	0	1e+00	ENSRNOG00000064438
Indifference point AUC	42.09	1	1	100	0	1e+00	ENSRNOG00000064438
Indifference point function ln k	4.41	1	0	0	0	1e+00	ENSRNOG00000064438
Indifference point function log k	4.41	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 0 sec	17.74	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 12 sec	102.69	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 18 sec	175.33	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 24 sec	28.3	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 6 sec	98.45	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 0 sec	8.14	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 12 sec	26.07	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 18 sec	10.52	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 24 sec	62.69	1	1	100	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 6 sec	44.17	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotor testing distance	11.51	1	0	0	0	1e+00	ENSRNOG00000064438
Locomotor testing rearing	16.83	1	1	100	0	1e+00	ENSRNOG00000064438
Light reinforcement 1	54.81	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time number correct	9.43	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time num false alarms	56.4	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time num false alarms AUC	79.45	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time trials correct on left	9.43	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time trials on left	10.33	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time mean	41.28	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time mean AUC	57.96	1	1	100	0	1e+00	ENSRNOG00000064438
Median of all reaction times	51.19	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time false alarm rate	63.39	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time premature initiation rate	32.14	1	1	100	0	1e+00	ENSRNOG00000064438
Std. dev. reaction times	17.36	1	1	100	0	1e+00	ENSRNOG00000064438
Reaction time trials completed	10.33	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time trials AUC	15.57	1	0	0	0	1e+00	ENSRNOG00000064438
Social responses	74.35	1	1	100	0	1e+00	ENSRNOG00000064438
Social time	7.75	1	0	0	0	1e+00	ENSRNOG00000064438
Cocaine response after cond. corrected	77.95	1	1	100	0	1e+00	ENSRNOG00000064438
Cocaine response after cond. not corrected	102.33	1	1	100	0	1e+00	ENSRNOG00000064438
Cocaine response before conditioning	17.37	1	1	100	0	1e+00	ENSRNOG00000064438
Saline control response	30.34	1	1	100	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	29.4	1	1	100	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	40.66	1	1	100	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active responses	7.43	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	20.59	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	36.27	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	104.88	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	130.08	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. index score	62.19	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	67.08	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	17.16	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	150.01	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. intertrial magazine entries	63.93	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	55.11	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	30.81	1	1	100	0	1e+00	ENSRNOG00000064438
Conditioned reinforcement - actives	13.02	1	0	0	0	1e+00	ENSRNOG00000064438
Conditioned locomotion	9.86	1	0	0	0	1e+00	ENSRNOG00000064438
Intermittent access intake day 1-15 change	61.45	1	1	100	0	1e+00	ENSRNOG00000064438
Intermittent access intake escalation	82.51	1	1	100	0	1e+00	ENSRNOG00000064438
Intermittent access intake escalation 2	24.72	1	1	100	0	1e+00	ENSRNOG00000064438
Intermitt. access day 1 inactive lever presses	19.44	1	1	100	0	1e+00	ENSRNOG00000064438
Intermitt. access escalation Index	9.22	1	0	0	0	1e+00	ENSRNOG00000064438
Intermittent access day 1 total infusions	32.74	1	1	100	0	1e+00	ENSRNOG00000064438
Intermittent access day 1 locomotion	18.42	1	1	100	0	1e+00	ENSRNOG00000064438
Post-drug Anxiety	13.65	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 active lever presses	11.8	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 breakpoint	10.37	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 inactive lever presses	10.82	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 2 active lever presses	12.24	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 2 breakpoint	38.7	1	1	100	0	1e+00	ENSRNOG00000064438
Short access day 10 total inactive lever presses	9.05	1	0	0	0	1e+00	ENSRNOG00000064438
Short access day 10 total infusions	14.36	1	1	100	0	1e+00	ENSRNOG00000064438
Short access day 1 locomotion	11.36	1	0	0	0	1e+00	ENSRNOG00000064438
Compulsive drug intake	28.2	1	1	100	0	1e+00	ENSRNOG00000064438
One hour access (0.3 mA shock)	10.45	1	0	0	0	1e+00	ENSRNOG00000064438
Context. condit. distance diff. score	149.78	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 1	117.78	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 1	374.74	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 2	82.2	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 2	775.97	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 3	116.11	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 3	82.39	1	1	100	0	1e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 3	8.83	1	0	0	0	1e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 3	25.57	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 7	66.34	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 7	21.3	1	1	100	0	1e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 7	42.65	1	1	100	0	1e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 7	63.39	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 8	102.75	1	1	100	0	1e+00	ENSRNOG00000064438
Degree of sensitization distance	140.58	1	1	100	0	1e+00	ENSRNOG00000064438
Degree of sensitization stereotypy	22.91	1	1	100	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	5.6	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	65.09	1	1	100	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active responses	12.19	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	17.25	1	0	0	0	1e+00	ENSRNOG00000064438
Incentive salience index mean	15.58	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. lever presses	20.32	1	1	100	0	1e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 1	16.37	1	0	0	0	1e+00	ENSRNOG00000064438
Time in novel zone, hab. session 1	12.91	1	0	0	0	1e+00	ENSRNOG00000064438
Total zone transitions, hab. session 1	415.63	1	1	100	0	1e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 1	171.39	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 1	218.59	1	1	100	0	1e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 2	27.96	1	1	100	0	1e+00	ENSRNOG00000064438
Time in novel zone, hab. session 2	34.06	1	1	100	0	1e+00	ENSRNOG00000064438
Total zone transitions, hab. session 2	256.06	1	1	100	0	1e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 2	133.05	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 2	139.44	1	1	100	0	1e+00	ENSRNOG00000064438
Total zone transitions, NPP test	228.75	1	1	100	0	1e+00	ENSRNOG00000064438
Total locomotion distance, NPP test	163.42	1	1	100	0	1e+00	ENSRNOG00000064438
Locomotion velocity, NPP test	195.87	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	8.63	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	56.4	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	23.11	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. index score	28.93	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	16.59	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	13.28	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	34.9	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	50.47	1	1	100	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	29.37	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: apparent density	18.55	1	1	100	0	1e+00	ENSRNOG00000064438
Bone surface	28.89	1	1	100	0	1e+00	ENSRNOG00000064438
Bone volume	32.3	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: connectivity density	8.5	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: cortical porosity	109.3	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: cortical porosity	91.2	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: cortical thickness	8.79	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: cortical thickness	17.92	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: elastic displacement	17.29	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: endosteal estimation	12.68	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: final force	39.54	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: final moment	31.87	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: marrow area	10.6	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: maximum force	41.95	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: maximum moment	29.46	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: minimum diameter	57.33	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: periosteal estimation	7.75	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: periosteal perimeter	6.39	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: post-yield work	82.77	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: stiffness	90.38	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: tissue strength	80.98	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: trabecular number	39.36	1	1	100	0	1e+00	ENSRNOG00000064438
Bone: trabecular spacing	5.66	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: trabecular thickness	10.38	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: trabecular tissue density	43.06	1	1	100	0	1e+00	ENSRNOG00000064438
Distance traveled before self-admin	9.75	1	0	0	0	1e+00	ENSRNOG00000064438
Delta time in open arm before/after self-admin	23.55	1	1	100	0	1e+00	ENSRNOG00000064438
Extinction: sum of active levers before priming	12.19	1	0	0	0	1e+00	ENSRNOG00000064438
Active lever presses in extinction session 6	9.21	1	0	0	0	1e+00	ENSRNOG00000064438
Delta distance traveled before/after self-admin	8.72	1	0	0	0	1e+00	ENSRNOG00000064438
Delta ambulatory time before/after self-admin	4.67	1	0	0	0	1e+00	ENSRNOG00000064438
Time in closed arm before self-admin	50.04	1	1	100	0	1e+00	ENSRNOG00000064438
Time in closed arm after self-admin	25.79	1	1	100	0	1e+00	ENSRNOG00000064438
Time in open arm after self-admin	18.45	1	1	100	0	1e+00	ENSRNOG00000064438
Delta time to tail flick, vehicle, before/after SA	7.54	1	0	0	0	1e+00	ENSRNOG00000064438
Delta time to tail flick, test, before/after SA	20.03	1	0	0	0	1e+00	ENSRNOG00000064438
Ambulatory time before self-admin	5.66	1	0	0	0	1e+00	ENSRNOG00000064438
Fecal boli incidents, locomotor time 1	11.77	1	0	0	0	1e+00	ENSRNOG00000064438
Change in fecal boli incidents, locomotor task	8.82	1	0	0	0	1e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 1	19.54	1	0	0	0	1e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 2	19.42	1	1	100	0	1e+00	ENSRNOG00000064438
Total resting periods, locomotor time 2	6.01	1	0	0	0	1e+00	ENSRNOG00000064438
Rest time, locomotor task time 2	7	1	0	0	0	1e+00	ENSRNOG00000064438
Distance moved, locomotor task time 2	9.35	1	0	0	0	1e+00	ENSRNOG00000064438
Weight adjusted by age	16.68	1	1	100	0	1e+00	ENSRNOG00000064438
Seeking ratio, delayed vs. immediate footshock	5.34	1	0	0	0	1e+00	ENSRNOG00000064438
Locomotion in novel chamber	10.2	1	0	0	0	1e+00	ENSRNOG00000064438
Run reversals in cocaine runway, males	25.4	1	1	100	0	1e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway	11.76	1	0	0	0	1e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway, M	5.59	1	0	0	0	1e+00	ENSRNOG00000064438
Cd content in liver	140.46	1	1	100	0	1e+00	ENSRNOG00000064438
Co content in liver	83.15	1	1	100	0	1e+00	ENSRNOG00000064438
Fe content in liver	10.34	1	0	0	0	1e+00	ENSRNOG00000064438
K content in liver	62.65	1	1	100	0	1e+00	ENSRNOG00000064438
Mn content in liver	130.23	1	1	100	0	1e+00	ENSRNOG00000064438
Rb content in liver	18.62	1	1	100	0	1e+00	ENSRNOG00000064438
Se content in liver	46.95	1	1	100	0	1e+00	ENSRNOG00000064438
Sr content in liver	5.6	1	0	0	0	1e+00	ENSRNOG00000064438
Zn content in liver	25.95	1	1	100	0	1e+00	ENSRNOG00000064438

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.47
Adipose	alternative TSS	0	0	1.54
Adipose	gene expression	0	0	1.42
Adipose	isoform ratio	0	0	1.42
Adipose	intron excision ratio	0	0	1.24
Adipose	mRNA stability	0	0	1.42
BLA	alternative polyA	0	0	1.51
BLA	alternative TSS	0	0	1.5
BLA	gene expression	0	0	1.4
BLA	isoform ratio	0	0	1.46
BLA	intron excision ratio	0	0	1.38
BLA	mRNA stability	0	0	1.45
Brain	alternative polyA	0	0	1.51
Brain	alternative TSS	0	0	1.54
Brain	gene expression	0	0	1.39
Brain	isoform ratio	0	0	1.42
Brain	intron excision ratio	0	0	1.39
Brain	mRNA stability	0	0	1.43
Eye	alternative polyA	0	0	1.63
Eye	alternative TSS	0	0	1.54
Eye	gene expression	0	0	1.31
Eye	isoform ratio	0	0	1.57
Eye	intron excision ratio	0	0	1.4
Eye	mRNA stability	0	0	1.6
IL	alternative polyA	0	0	1.56
IL	alternative TSS	0	0	1.59
IL	gene expression	0	0	1.43
IL	isoform ratio	0	0	1.53
IL	intron excision ratio	0	0	1.47
IL	mRNA stability	0	0	1.43
LHb	alternative polyA	0	0	1.46
LHb	alternative TSS	0	0	1.62
LHb	gene expression	0	0	1.46
LHb	isoform ratio	0	0	1.47
LHb	intron excision ratio	0	0	1.39
LHb	mRNA stability	0	0	1.4
Liver	alternative polyA	0	0	1.4
Liver	alternative TSS	0	0	1.42
Liver	gene expression	0	0	1.41
Liver	isoform ratio	0	0	1.38
Liver	intron excision ratio	0	0	1.4
Liver	mRNA stability	0	0	1.42
NAcc	alternative polyA	0	0	1.54
NAcc	alternative TSS	0	0	1.56
NAcc	gene expression	0	0	1.39
NAcc	isoform ratio	0	0	1.45
NAcc	intron excision ratio	0	0	1.4
NAcc	mRNA stability	0	0	1.46
OFC	alternative polyA	0	0	1.6
OFC	alternative TSS	0	0	1.67
OFC	gene expression	0	0	1.43
OFC	isoform ratio	0	0	1.66
OFC	intron excision ratio	0	0	1.42
OFC	mRNA stability	0	0	1.4
PL	alternative polyA	0	0	1.52
PL	alternative TSS	0	0	1.53
PL	gene expression	0	0	1.43
PL	isoform ratio	2	0.1	1.5
PL	intron excision ratio	0	0	1.42
PL	mRNA stability	0	0	1.45