Hub : Traits : Extensor digitorum longus weight : ← →

chr14:8,196,668-10,268,633

Trait: Extensor digitorum longus weight

Best TWAS P=7.377084e-08 · Best GWAS P=1.861017e-07 conditioned to 0.4707333

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Sec31a	isoform ratio	ENSRNOT00000097169	0.05	0.02	blup	3203	0.03	7.9e-04	5.0	5.3	1.0e-07	-0.94	0.35	0.63	FALSE
2	Brain	Lin54	alternative TSS	ENSRNOT00000003006	0.03	0.02	lasso	2	0.02	1.2e-02	-5.2	-5.2	1.9e-07	0.96	0.31	0.59	FALSE
3	Brain	Lin54	alternative TSS	ENSRNOT00000003006	0.04	0.02	blup	3225	0.03	1.5e-03	-5.2	-5.2	2.5e-07	0.87	0.30	0.67	FALSE
4	Brain	Cops4	gene expression	ENSRNOG00000023650	0.15	0.10	enet	17	0.15	1.9e-13	-5.2	-5.2	2.5e-07	0.78	0.27	0.73	FALSE
5	Eye	Tmem150c	gene expression	ENSRNOG00000002258	0.31	0.10	blup	3691	0.15	2.9e-03	4.9	5.2	2.0e-07	-0.89	0.41	0.34	FALSE
6	LHb	Coq2	gene expression	ENSRNOG00000002194	0.24	0.08	top1	1	0.08	6.3e-03	5.1	-5.1	2.9e-07	0.90	0.17	0.06	FALSE
7	OFC	Hpse	gene expression	ENSRNOG00000002188	0.21	0.17	top1	1	0.17	7.0e-05	5.1	5.1	2.9e-07	-0.90	0.17	0.07	FALSE
8	PL	Enoph1	gene expression	ENSRNOG00000002262	0.07	0.03	blup	3631	0.07	8.3e-06	-5.1	5.2	1.7e-07	-0.90	0.28	0.72	FALSE
9	PL	Coq2	mRNA stability	ENSRNOG00000002194	0.04	0.04	top1	1	0.04	3.4e-04	-5.1	-5.1	2.8e-07	0.93	0.13	0.14	FALSE
10	PL	Lin54	mRNA stability	ENSRNOG00000002203	0.03	0.00	blup	3225	0.02	1.3e-02	4.4	-5.4	7.4e-08	0.91	0.35	0.52	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.