| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000019266 | 0.1610 | 0.0820 | 5.6e-10 | 0.162 | 0.174 | 0.185 | 0.183 | 5.2e-09 | 1.3e-09 | 3.4e-10 | 4.5e-10 |
| 2 | Brain | gene expression | ENSRNOG00000019266 | 0.1500 | 0.0720 | 1.7e-15 | 0.176 | 0.169 | 0.148 | 0.164 | 4.4e-16 | 2.0e-15 | 1.4e-13 | 4.6e-15 |
| 3 | Brain | mRNA stability | ENSRNOG00000019266 | 0.1181 | 0.0611 | 6.3e-12 | 0.129 | 0.127 | 0.123 | 0.127 | 5.1e-12 | 7.8e-12 | 2.0e-11 | 8.3e-12 |
| 4 | Liver | gene expression | ENSRNOG00000019266 | 0.0810 | 0.0610 | 3.3e-04 | 0.024 | 0.018 | 0.015 | 0.014 | 1.0e-03 | 3.7e-03 | 7.6e-03 | 9.0e-03 |
| 5 | Liver | mRNA stability | ENSRNOG00000019266 | 0.0755 | 0.0508 | 2.3e-03 | 0.010 | 0.009 | 0.005 | 0.008 | 2.5e-02 | 2.8e-02 | 7.6e-02 | 3.5e-02 |
| 6 | NAcc | gene expression | ENSRNOG00000019266 | 0.0770 | 0.0500 | 2.5e-06 | 0.071 | 0.062 | 0.057 | 0.066 | 5.3e-06 | 2.3e-05 | 4.8e-05 | 1.2e-05 |
| 7 | NAcc | mRNA stability | ENSRNOG00000019266 | 0.0545 | 0.0366 | 1.1e-04 | 0.036 | 0.023 | 0.021 | 0.031 | 1.1e-03 | 7.3e-03 | 9.8e-03 | 2.2e-03 |
| 8 | OFC | gene expression | ENSRNOG00000019266 | 0.2177 | 0.1350 | 4.1e-04 | 0.015 | 0.015 | 0.028 | 0.031 | 1.4e-01 | 1.4e-01 | 7.2e-02 | 6.4e-02 |
| 9 | OFC | mRNA stability | ENSRNOG00000019266 | 0.2495 | 0.1275 | 6.0e-05 | 0.116 | 0.056 | 0.029 | 0.102 | 1.1e-03 | 1.9e-02 | 6.9e-02 | 2.2e-03 |
| 10 | PL | gene expression | ENSRNOG00000019266 | 0.0955 | 0.0526 | 4.9e-09 | 0.135 | 0.120 | 0.116 | 0.131 | 1.9e-10 | 2.1e-09 | 4.3e-09 | 3.5e-10 |
| 11 | PL | mRNA stability | ENSRNOG00000019266 | 0.0468 | 0.0297 | 2.0e-04 | 0.061 | 0.043 | 0.045 | 0.057 | 2.1e-05 | 3.2e-04 | 2.2e-04 | 3.5e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tibialis anterior weight | 8.9 | 30.8 | 38.7 | 6.2 | 6.0 | 6.1 | 2.3 | 1.9 | 6.2 | 5.5 | 6.1 | 6.2 | 6.0 | 6.2 |
| Delay discounting total patch changes 24 sec | 6.6 | 8.3 | 11.3 | 3.2 | 3.1 | 3.4 | 1.7 | 1.4 | 3.1 | 2.8 | 3.0 | 3.1 | 3.2 | 3.1 |
| Extensor digitorum longus weight | 6.1 | 24.4 | 30.6 | 5.5 | 5.2 | 5.3 | 2.9 | 2.9 | 5.4 | 5.2 | 5.1 | 5.1 | 5.2 | 5.5 |
| Pavlov. Cond. magazine entry number | 5.9 | 7.2 | 10.4 | -3.0 | -3.2 | -2.2 | -1.2 | -0.7 | -3.2 | -2.5 | -3.2 | -2.4 | -3.2 | -3.2 |
| Delay discounting total patch changes 12 sec | 5.3 | 7.1 | 9.6 | 3.0 | 2.9 | 3.0 | 0.8 | 0.2 | 3.0 | 2.4 | 3.0 | 3.0 | 3.1 | 2.9 |
| Sr content in liver | 5.3 | 4.8 | 6.4 | 2.5 | 2.4 | 2.3 | 0.4 | 0.1 | 2.4 | 2.1 | 2.5 | 2.5 | 2.4 | 2.5 |
| Reaction time premature initiations | 4.6 | 6.6 | 12.2 | 3.0 | 2.6 | 2.9 | 0.4 | 1.2 | 2.9 | 3.5 | 2.0 | 2.7 | 2.7 | 2.9 |
| One hour access (shock baseline) | 4.5 | 5.2 | 8.7 | -2.8 | -2.5 | -2.8 | 0.2 | -0.4 | -2.5 | -3.0 | -1.5 | -2.5 | -2.3 | -2.6 |
| Bone: trabecular tissue density | 4.2 | 5.9 | 7.3 | -2.5 | -2.7 | -2.1 | -2.1 | -1.9 | -2.7 | -2.5 | -2.4 | -2.3 | -2.6 | -2.7 |
| Reaction time premature initiation rate | 3.7 | 5.0 | 8.8 | 2.5 | 2.3 | 2.5 | 0.9 | 1.6 | 2.4 | 3.0 | 1.6 | 2.4 | 2.3 | 2.5 |
| Zn content in liver | 3.7 | 4.1 | 5.2 | 2.2 | 2.2 | 2.3 | 1.4 | 1.0 | 2.2 | 1.8 | 2.2 | 2.1 | 2.3 | 2.2 |
| Body weight | 3.5 | 14.7 | 17.6 | 4.2 | 3.8 | 4.0 | 2.8 | 3.0 | 4.2 | 4.2 | 3.7 | 4.2 | 3.8 | 4.2 |
| Pavlov. Cond. magazine entry latency | 3.5 | 4.0 | 6.0 | 2.3 | 2.4 | 1.6 | 0.6 | 0.3 | 2.4 | 2.0 | 2.2 | 1.8 | 2.4 | 2.4 |
| Extinction: sum of active levers before priming | 3.5 | 3.5 | 5.1 | 2.1 | 2.2 | 2.0 | 0.8 | 0.6 | 2.1 | 1.8 | 2.1 | 1.7 | 2.3 | 2.1 |
| One hour access (0.3 mA shock) | 3.3 | 3.9 | 5.5 | -2.3 | -2.3 | -2.3 | 0.5 | 0.1 | -2.2 | -2.3 | -1.7 | -2.1 | -2.2 | -2.1 |
| Total heroin consumption | 3.2 | 3.8 | 5.0 | 2.2 | 2.2 | 2.2 | -0.5 | -0.7 | 2.2 | 1.9 | 2.2 | 2.1 | 2.2 | 2.1 |
| Indifference point function ln k | 3.0 | 4.3 | 9.7 | -2.3 | -2.4 | -1.5 | -0.8 | 0.6 | -2.5 | -1.2 | -3.1 | -1.9 | -2.3 | -2.6 |
| Indifference point function log k | 3.0 | 4.3 | 9.7 | -2.3 | -2.4 | -1.5 | -0.8 | 0.6 | -2.5 | -1.2 | -3.1 | -1.9 | -2.3 | -2.6 |
| Intermittent access day 15 total infusions | 2.9 | 3.3 | 5.4 | -2.2 | -1.9 | -2.3 | 0.7 | 0.3 | -1.9 | -2.2 | -1.3 | -2.0 | -1.9 | -2.0 |
| Bone: maximum force | 2.9 | 5.0 | 9.7 | 2.1 | 2.1 | 1.7 | 3.1 | 2.7 | 2.2 | 1.7 | 2.4 | 1.7 | 2.2 | 2.2 |
| Rest time, locomotor task time 2 | 2.8 | 3.3 | 4.4 | -2.0 | -2.1 | -1.8 | -0.6 | -0.7 | -2.1 | -2.0 | -2.0 | -1.9 | -2.0 | -1.9 |
| Latency to leave start box in cocaine runway, M | 2.8 | 2.7 | 3.6 | -1.9 | -1.9 | -1.8 | -0.2 | -0.1 | -1.8 | -1.5 | -1.7 | -1.8 | -1.9 | -1.9 |
| BMI with tail | 2.7 | 8.7 | 17.5 | 2.6 | 2.5 | 2.6 | 4.0 | 4.2 | 2.7 | 2.7 | 2.4 | 2.8 | 2.5 | 2.7 |
| Bone: maximum moment | 2.7 | 4.7 | 8.8 | 2.0 | 2.1 | 1.6 | 3.0 | 2.5 | 2.2 | 1.7 | 2.3 | 1.7 | 2.1 | 2.2 |
| Bone: cortical thickness | 2.6 | 4.4 | 6.4 | 2.5 | 2.2 | 2.3 | -0.6 | -0.4 | 2.4 | 2.5 | 1.9 | 2.2 | 2.2 | 2.4 |
| Co content in liver | 2.5 | 3.0 | 7.9 | -1.5 | -1.5 | -1.1 | -2.8 | -2.2 | -1.6 | -0.9 | -2.1 | -1.5 | -1.4 | -1.7 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.4 | 3.1 | 4.8 | 2.0 | 2.2 | 1.1 | 1.2 | 0.7 | 2.1 | 1.5 | 2.2 | 1.2 | 2.1 | 2.2 |
| Progressive ratio test 2 breakpoint | 2.4 | 2.7 | 4.2 | -2.0 | -1.8 | -2.0 | 0.1 | -0.3 | -1.8 | -2.0 | -1.2 | -1.7 | -1.7 | -1.9 |
| Locomotion velocity, session 2 | 2.4 | 2.8 | 3.9 | 1.9 | 1.6 | 2.0 | 1.1 | 1.1 | 1.8 | 1.7 | 1.6 | 2.0 | 1.6 | 1.8 |
| Glucose | 2.3 | 3.6 | 5.0 | -2.1 | -2.2 | -2.2 | 0.6 | 0.6 | -2.0 | -2.0 | -1.9 | -2.0 | -2.1 | -2.0 |
| Soleus weight | 2.3 | 6.8 | 9.1 | -2.8 | -3.0 | -2.6 | -0.8 | -0.5 | -3.0 | -2.6 | -3.0 | -2.9 | -3.0 | -2.9 |
| Active lever presses in extinction session 6 | 2.2 | 2.1 | 4.1 | 1.6 | 1.8 | 1.3 | 0.2 | -0.3 | 1.8 | 1.2 | 2.0 | 1.2 | 1.8 | 1.6 |
| Locomotion in novel chamber post-restriction | 2.2 | 2.7 | 3.9 | -1.9 | -2.0 | -1.4 | -0.7 | -0.8 | -2.0 | -1.9 | -1.5 | -1.4 | -1.9 | -1.9 |
| Length with tail | 2.1 | 7.8 | 10.6 | 3.3 | 2.9 | 3.1 | 0.6 | 0.7 | 3.2 | 3.1 | 2.8 | 3.0 | 2.9 | 3.2 |
| Saline control response | 2.1 | 2.9 | 4.8 | 1.9 | 1.7 | 1.9 | 0.3 | 0.5 | 1.9 | 2.2 | 1.6 | 1.7 | 1.8 | 1.9 |
| Pavlov. Cond. index score | 2.1 | 2.8 | 4.5 | 1.8 | 2.0 | 1.0 | 1.3 | 0.7 | 2.0 | 1.4 | 2.1 | 1.1 | 2.0 | 2.1 |
| Conditioned reinforcement - actives | 2.1 | 2.0 | 3.3 | -1.7 | -1.3 | -1.8 | -0.4 | -0.9 | -1.5 | -1.8 | -0.8 | -1.7 | -1.4 | -1.6 |
| Progressive ratio test 1 breakpoint | 2.1 | 2.2 | 3.4 | -1.9 | -1.6 | -1.7 | -0.4 | -0.5 | -1.7 | -1.7 | -1.2 | -1.3 | -1.6 | -1.8 |
| Novel to familiar place preference ratio | 2.1 | 2.2 | 4.0 | 1.6 | 1.5 | 1.3 | 1.2 | 0.8 | 1.6 | 1.1 | 2.0 | 1.8 | 1.3 | 1.7 |
| Mn content in liver | 2.1 | 2.4 | 4.5 | 1.6 | 1.7 | 1.3 | 1.0 | 0.7 | 1.8 | 1.5 | 2.1 | 1.4 | 1.5 | 1.8 |
| Short access day 10 total inactive lever presses | 2.0 | 2.2 | 4.0 | -1.6 | -1.7 | -1.3 | -0.7 | -0.4 | -1.7 | -1.3 | -2.0 | -1.4 | -1.7 | -1.7 |
| Bone: final force | 2.0 | 3.2 | 3.8 | 1.9 | 1.9 | 1.6 | 1.9 | 1.6 | 1.9 | 1.6 | 2.0 | 1.6 | 1.9 | 1.9 |
| Distance traveled before self-admin | 2.0 | 2.2 | 3.6 | 1.7 | 1.6 | 1.4 | 0.9 | 0.4 | 1.7 | 1.3 | 1.9 | 1.1 | 1.8 | 1.8 |
| Time >=10cm from walls, locomotor time 1 | 2.0 | 2.0 | 3.7 | -1.6 | -1.4 | -1.8 | 0.9 | 0.2 | -1.4 | -1.9 | -0.8 | -1.8 | -1.4 | -1.6 |
| Retroperitoneal fat weight | 1.9 | 6.4 | 9.0 | -2.9 | -3.0 | -2.7 | 0.6 | 0.9 | -2.8 | -2.5 | -2.7 | -2.5 | -3.0 | -2.8 |
| Pavlov. Cond. latency score | 1.9 | 2.5 | 4.0 | 1.7 | 1.9 | 0.9 | 1.4 | 0.8 | 1.9 | 1.2 | 2.0 | 1.1 | 1.9 | 1.9 |
| Progressive ratio test 1 active lever presses | 1.9 | 1.9 | 3.1 | -1.8 | -1.5 | -1.6 | -0.3 | -0.4 | -1.6 | -1.6 | -1.2 | -1.2 | -1.5 | -1.7 |
| Bone surface | 1.9 | 3.3 | 5.7 | 1.8 | 2.0 | 1.4 | 2.4 | 1.8 | 1.8 | 1.2 | 2.3 | 1.3 | 1.9 | 1.8 |
| Bone: endosteal perimeter | 1.9 | 4.0 | 6.6 | -1.9 | -1.9 | -2.2 | 2.6 | 1.8 | -1.8 | -2.4 | -1.3 | -2.2 | -1.8 | -1.8 |
| Bone: final moment | 1.9 | 3.1 | 3.8 | 1.8 | 1.8 | 1.6 | 1.8 | 1.5 | 1.9 | 1.6 | 1.9 | 1.5 | 1.8 | 1.9 |
| Locomotion in novel chamber | 1.9 | 2.3 | 4.5 | -1.8 | -1.5 | -2.1 | 0.6 | 0.1 | -1.5 | -1.9 | -0.9 | -1.9 | -1.5 | -1.5 |
| Length without tail | 1.8 | 4.0 | 5.2 | 2.3 | 2.0 | 2.2 | 1.2 | 0.9 | 2.2 | 2.1 | 2.0 | 1.9 | 2.2 | 2.3 |
| Indifference point AUC | 1.8 | 2.2 | 4.4 | 1.7 | 1.7 | 1.2 | 0.7 | -0.1 | 1.8 | 0.9 | 2.1 | 1.2 | 1.8 | 1.8 |
| Conditioned locomotion | 1.8 | 2.2 | 3.5 | -1.9 | -1.5 | -1.6 | 0.5 | 0.4 | -1.6 | -1.6 | -1.3 | -1.6 | -1.5 | -1.9 |
| Stereotopy head waving duration, day 7 | 1.8 | 2.2 | 3.9 | 1.6 | 1.7 | 1.3 | 1.2 | 1.0 | 1.6 | 1.3 | 2.0 | 1.5 | 1.5 | 1.5 |
| Bone: connectivity density | 1.7 | 2.6 | 3.8 | 1.5 | 1.7 | 1.4 | 1.9 | 1.9 | 1.6 | 1.4 | 1.6 | 1.4 | 1.7 | 1.6 |
| Ambulatory time before self-admin | 1.7 | 1.8 | 4.0 | 1.5 | 1.6 | 1.0 | 0.8 | 0.1 | 1.6 | 0.9 | 2.0 | 0.9 | 1.6 | 1.6 |
| Progressive ratio test 2 active lever presses | 1.6 | 1.7 | 2.6 | -1.6 | -1.4 | -1.6 | 0.6 | 0.2 | -1.4 | -1.6 | -0.8 | -1.3 | -1.3 | -1.5 |
| Total sessions with >9 infusions | 1.6 | 1.8 | 2.5 | -1.6 | -1.4 | -1.4 | 0.7 | 0.9 | -1.5 | -1.3 | -1.5 | -1.1 | -1.4 | -1.5 |
| Breakpoint value in progressive ratio session | 1.6 | 1.8 | 3.2 | 1.5 | 1.6 | 1.3 | -0.2 | -0.5 | 1.6 | 1.1 | 1.8 | 1.3 | 1.5 | 1.5 |
| Delta time in closed arm before/after self-admin | 1.6 | 1.5 | 3.3 | 1.2 | 1.0 | 1.8 | 0.4 | 1.2 | 1.0 | 1.8 | 0.3 | 1.8 | 1.0 | 1.0 |
| Weight adjusted by age | 1.6 | 1.8 | 2.7 | 1.4 | 1.5 | 0.9 | 1.2 | 0.9 | 1.5 | 1.2 | 1.6 | 1.2 | 1.5 | 1.5 |
| Delay discounting water rate 12 sec | 1.5 | 2.3 | 5.2 | -1.5 | -1.8 | -1.0 | -1.7 | -0.6 | -1.5 | -0.6 | -2.3 | -1.5 | -1.8 | -1.7 |
| Pavlov. Cond. intertrial magazine entries | 1.5 | 1.9 | 2.8 | -1.4 | -1.6 | -1.2 | -0.8 | -1.0 | -1.5 | -1.6 | -1.3 | -1.4 | -1.7 | -1.5 |
| Intermittent access intake day 1-15 change | 1.5 | 1.5 | 2.4 | -1.2 | -1.0 | -1.5 | -1.2 | -1.5 | -1.1 | -1.6 | -0.5 | -1.5 | -1.0 | -1.0 |
| Intermitt. access day 1 inactive lever presses | 1.5 | 1.7 | 2.4 | -1.5 | -1.5 | -1.4 | 0.0 | -0.1 | -1.4 | -1.5 | -1.2 | -1.4 | -1.5 | -1.4 |
| Intermittent access day 1 total infusions | 1.5 | 1.7 | 5.4 | -1.2 | -1.0 | -1.0 | 2.3 | 2.2 | -1.0 | -0.9 | -0.8 | -0.7 | -1.0 | -1.0 |
| Intermittent access standard deviation | 1.5 | 1.6 | 2.3 | -1.4 | -1.2 | -1.5 | -1.0 | -1.3 | -1.2 | -1.5 | -0.7 | -1.3 | -1.2 | -1.4 |
| Bone: marrow area | 1.5 | 3.3 | 6.0 | -1.7 | -1.6 | -1.8 | 2.5 | 2.1 | -1.7 | -1.9 | -1.4 | -1.8 | -1.6 | -1.7 |
| Diff in mean of infusions in LGA sessions | 1.5 | 1.7 | 2.3 | 1.4 | 1.5 | 1.5 | -0.6 | -0.7 | 1.4 | 1.2 | 1.4 | 1.5 | 1.5 | 1.3 |
| Tibia length | 1.4 | 3.8 | 9.1 | 1.9 | 2.0 | 1.5 | 2.0 | 0.8 | 2.2 | 1.2 | 3.0 | 1.8 | 2.0 | 2.1 |
| Total zone transitions, hab. session 2 | 1.4 | 1.8 | 2.8 | 1.5 | 1.3 | 1.5 | 1.0 | 1.5 | 1.3 | 1.7 | 0.8 | 1.3 | 1.3 | 1.4 |
| Time in novel zone, NPP test | 1.4 | 1.4 | 2.5 | 1.3 | 1.2 | 1.0 | 1.1 | 0.7 | 1.3 | 0.9 | 1.6 | 1.5 | 1.0 | 1.4 |
| Bone: endosteal estimation | 1.4 | 3.1 | 6.5 | -1.6 | -1.5 | -1.7 | 2.6 | 2.1 | -1.6 | -1.8 | -1.3 | -1.7 | -1.5 | -1.5 |
| K content in liver | 1.4 | 1.4 | 2.9 | 1.1 | 1.0 | 0.9 | 1.7 | 1.5 | 1.2 | 1.0 | 1.1 | 0.8 | 0.9 | 1.2 |
| Parametrial fat weight | 1.3 | 2.5 | 3.5 | -1.8 | -1.7 | -1.7 | 1.0 | 0.9 | -1.6 | -1.9 | -1.5 | -1.8 | -1.6 | -1.8 |
| Pavlov. Cond. response bias | 1.3 | 1.7 | 2.9 | 1.5 | 1.6 | 0.8 | 0.6 | 0.3 | 1.6 | 1.2 | 1.6 | 0.9 | 1.6 | 1.7 |
| Intermittent access total locomotion | 1.3 | 1.4 | 8.1 | -0.6 | -0.2 | -0.5 | 2.9 | 2.5 | -0.3 | -0.5 | 0.2 | -0.3 | -0.2 | -0.4 |
| Time in novel zone, hab. session 1 | 1.3 | 1.2 | 1.8 | -1.1 | -1.3 | -0.9 | -1.1 | -0.7 | -1.2 | -0.9 | -1.3 | -1.1 | -1.2 | -1.2 |
| Novelty place preference | 1.3 | 1.3 | 2.7 | 1.2 | 1.1 | 0.9 | 1.0 | 0.6 | 1.3 | 0.8 | 1.7 | 1.4 | 1.0 | 1.3 |
| Bone: post-yield work | 1.3 | 1.8 | 9.7 | -0.7 | -0.3 | -1.0 | 3.1 | 2.4 | -0.5 | -1.2 | 0.1 | -0.9 | -0.2 | -0.4 |
| Delta time in open arm before/after self-admin | 1.3 | 1.3 | 3.0 | 1.2 | 1.3 | 0.9 | 0.7 | 0.1 | 1.3 | 0.6 | 1.7 | 0.9 | 1.4 | 1.3 |
| Rest time, locomotor task time 1 | 1.3 | 1.5 | 1.8 | -1.2 | -1.3 | -1.1 | -0.9 | -1.2 | -1.3 | -1.4 | -1.2 | -1.3 | -1.3 | -1.0 |
| Pavlov. Cond. change in total contacts | 1.2 | 1.6 | 3.3 | 1.4 | 1.6 | 0.6 | 1.1 | 0.4 | 1.6 | 0.8 | 1.8 | 0.4 | 1.6 | 1.6 |
| Intermittent access day 1 locomotion | 1.2 | 1.2 | 6.0 | -0.5 | -0.3 | -0.2 | 2.4 | 2.5 | -0.4 | -0.2 | -0.5 | 0.1 | -0.3 | -0.5 |
| Compulsive drug intake | 1.2 | 1.2 | 2.4 | 1.4 | 1.0 | 1.4 | -0.9 | -0.5 | 1.1 | 1.5 | 0.2 | 1.3 | 0.9 | 1.3 |
| Incentive salience index mean | 1.2 | 1.5 | 1.8 | 1.3 | 1.3 | 1.1 | 1.2 | 1.1 | 1.3 | 1.3 | 1.3 | 1.0 | 1.2 | 1.3 |
| Pavlov. Cond. lever latency | 1.2 | 1.5 | 2.4 | -1.2 | -1.3 | -0.9 | -1.6 | -1.3 | -1.3 | -1.1 | -1.3 | -1.0 | -1.3 | -1.2 |
| Run reversals in cocaine runway, females | 1.2 | 1.2 | 3.4 | 0.9 | 0.8 | 1.3 | 1.2 | 1.8 | 0.8 | 1.4 | 0.1 | 1.2 | 0.7 | 0.7 |
| Cd content in liver | 1.2 | 1.3 | 2.3 | -1.3 | -1.1 | -1.2 | -0.2 | -0.4 | -1.4 | -1.5 | -0.7 | -1.2 | -1.1 | -1.4 |
| Rb content in liver | 1.2 | 1.5 | 2.4 | -1.3 | -1.5 | -1.1 | -0.0 | 0.4 | -1.4 | -0.9 | -1.5 | -1.3 | -1.5 | -1.4 |
| BMI without tail | 1.1 | 2.3 | 3.5 | 1.5 | 1.3 | 1.5 | 1.4 | 1.9 | 1.5 | 1.7 | 1.2 | 1.8 | 1.2 | 1.5 |
| Delay discounting water rate 24 sec | 1.1 | 1.6 | 3.0 | -1.3 | -1.4 | -0.9 | -1.0 | -0.6 | -1.4 | -0.8 | -1.7 | -1.2 | -1.3 | -1.5 |
| Intermittent access total infusions | 1.1 | 1.3 | 2.6 | -1.2 | -1.0 | -1.3 | 1.6 | 1.2 | -1.0 | -1.2 | -0.5 | -1.0 | -0.9 | -1.0 |
| Lifetime Intake | 1.1 | 1.2 | 2.0 | -1.2 | -1.0 | -1.2 | 1.4 | 1.2 | -1.0 | -1.1 | -0.8 | -0.8 | -1.0 | -1.0 |
| Sum of active levers in priming session hrs 5-6 | 1.1 | 1.1 | 3.2 | 1.0 | 1.2 | 0.5 | -0.2 | -1.1 | 1.2 | 0.2 | 1.8 | 0.5 | 1.2 | 1.2 |
| Bouts of movement, locomotor time 2 | 1.1 | 1.2 | 2.0 | 1.3 | 1.2 | 1.1 | -0.0 | -0.2 | 1.2 | 1.1 | 1.2 | 1.1 | 1.2 | 1.4 |
| Delay discounting total patch changes 6 sec | 1.0 | 1.5 | 2.3 | 1.3 | 1.2 | 1.5 | 0.9 | 0.8 | 1.2 | 1.3 | 1.0 | 1.3 | 1.4 | 1.3 |
| Delay discounting water rate 6 sec | 1.0 | 1.5 | 3.6 | -1.2 | -1.5 | -0.7 | -1.3 | -0.5 | -1.4 | -0.4 | -1.9 | -1.0 | -1.4 | -1.3 |
| Intermittent access intake escalation | 1.0 | 0.9 | 1.7 | -0.9 | -0.8 | -1.2 | -1.0 | -1.3 | -0.8 | -1.3 | -0.3 | -1.2 | -0.7 | -0.8 |
| Total zone transitions, NPP test | 1.0 | 1.5 | 2.5 | 1.3 | 1.2 | 1.6 | 0.5 | 0.8 | 1.2 | 1.3 | 1.0 | 1.5 | 1.2 | 1.2 |
| Pavlov. Cond. magazine entry latency | 1.0 | 1.3 | 2.7 | 1.0 | 1.2 | 0.5 | 1.6 | 1.1 | 1.3 | 0.7 | 1.3 | 0.7 | 1.3 | 1.2 |
| Bone volume | 1.0 | 1.6 | 4.7 | 1.0 | 1.3 | 0.7 | 2.2 | 1.6 | 1.1 | 0.5 | 1.6 | 0.6 | 1.3 | 1.1 |
| Bone: minimum diameter | 1.0 | 1.8 | 6.4 | -0.9 | -0.9 | -1.2 | 2.5 | 2.1 | -0.9 | -1.2 | -0.7 | -1.3 | -0.9 | -0.8 |
| Bone: trabecular number | 1.0 | 1.5 | 3.8 | 0.9 | 1.2 | 0.9 | 1.9 | 1.7 | 1.0 | 0.8 | 1.4 | 0.8 | 1.2 | 1.0 |
| Tail length | 0.9 | 2.7 | 3.8 | 1.9 | 1.7 | 1.8 | -1.0 | -0.6 | 1.9 | 2.0 | 1.4 | 2.0 | 1.5 | 1.8 |
| Locomotor testing rearing | 0.9 | 1.3 | 3.1 | -1.2 | -1.3 | -1.1 | -0.8 | -0.3 | -1.3 | -0.6 | -1.8 | -1.1 | -1.4 | -1.3 |
| Intermittent access terminal intake (last 3 days) | 0.9 | 1.0 | 2.8 | -1.0 | -0.7 | -1.2 | 1.7 | 1.2 | -0.7 | -1.2 | -0.1 | -0.9 | -0.7 | -0.8 |
| Baseline Anxiety | 0.9 | 1.0 | 1.4 | 1.2 | 1.1 | 1.2 | -0.1 | 0.1 | 1.1 | 1.2 | 0.9 | 1.1 | 1.1 | 1.1 |
| Short access day 1 total infusions | 0.9 | 1.0 | 1.4 | -1.1 | -1.0 | -1.0 | 0.8 | 0.9 | -1.0 | -0.9 | -1.2 | -0.7 | -1.1 | -1.0 |
| Short access day 10 total infusions | 0.9 | 1.0 | 4.1 | -0.7 | -0.5 | -0.5 | 2.0 | 2.0 | -0.5 | -0.4 | -0.5 | -0.3 | -0.5 | -0.6 |
| Locomotion velocity, session 3 | 0.9 | 1.0 | 5.0 | 0.6 | 0.2 | 0.8 | 1.8 | 2.2 | 0.5 | 0.8 | 0.3 | 0.7 | 0.4 | 0.5 |
| Condit. Reinf. active minus inactive responses | 0.9 | 1.0 | 1.3 | 1.1 | 1.1 | 1.0 | 0.5 | 0.4 | 1.1 | 1.1 | 1.1 | 0.9 | 1.1 | 1.1 |
| Delta ambulatory time before/after self-admin | 0.9 | 1.0 | 1.9 | -1.0 | -1.0 | -0.8 | -1.1 | -0.7 | -1.0 | -0.7 | -1.4 | -0.9 | -1.1 | -1.1 |
| Time in open arm before self-admin | 0.9 | 1.0 | 3.0 | -0.9 | -1.1 | -0.2 | -1.4 | -0.5 | -1.1 | -0.1 | -1.7 | -0.3 | -1.1 | -1.1 |
| Time to tail flick, vehicle, before self-admin | 0.9 | 0.9 | 3.2 | 0.7 | 0.7 | 0.7 | 1.8 | 1.6 | 0.7 | 0.4 | 0.8 | 0.8 | 0.7 | 0.8 |
| Time to tail flick, test, before self-admin | 0.9 | 0.9 | 3.8 | 0.6 | 0.4 | 0.9 | 1.6 | 1.9 | 0.4 | 0.8 | 0.1 | 0.9 | 0.4 | 0.5 |
| Mg content in liver | 0.9 | 0.9 | 3.3 | 0.6 | 0.5 | 0.7 | 1.8 | 1.8 | 0.7 | 0.6 | 0.7 | 0.5 | 0.5 | 0.6 |
| Locomotor testing distance | 0.8 | 1.3 | 3.7 | -1.1 | -1.2 | -0.6 | -1.2 | -0.1 | -1.3 | -0.1 | -1.9 | -0.6 | -1.3 | -1.4 |
| Condit. Reinf. active-inactive response ratio | 0.8 | 0.8 | 2.5 | -0.9 | -0.8 | -1.1 | 1.0 | 0.2 | -0.7 | -1.6 | 0.1 | -0.9 | -0.8 | -0.8 |
| Condit. Reinf. lever presses | 0.8 | 1.1 | 1.9 | 1.1 | 1.1 | 0.6 | 1.0 | 0.4 | 1.3 | 0.8 | 1.4 | 0.5 | 1.1 | 1.3 |
| Conditioned reinforcement - inactives | 0.8 | 0.9 | 1.6 | -1.1 | -0.8 | -1.3 | 0.8 | 0.3 | -0.9 | -1.2 | -0.4 | -1.2 | -1.0 | -0.9 |
| Short access day 1 total inactive lever presses | 0.8 | 0.9 | 1.3 | -1.1 | -0.8 | -0.9 | 0.8 | 1.0 | -1.0 | -0.8 | -1.0 | -0.7 | -1.0 | -1.1 |
| Short access total locomotion | 0.8 | 0.9 | 4.4 | 0.2 | 0.4 | 0.5 | 2.0 | 2.1 | 0.2 | 0.4 | 0.1 | 0.6 | 0.4 | 0.2 |
| Degree of sensitization stereotypy | 0.8 | 0.9 | 2.2 | 1.0 | 1.1 | 0.7 | 0.9 | 0.4 | 1.1 | 0.5 | 1.5 | 0.8 | 1.0 | 1.0 |
| Condit. Reinf. active responses | 0.8 | 1.0 | 1.7 | 1.0 | 1.1 | 0.8 | 1.2 | 0.8 | 1.1 | 0.7 | 1.3 | 0.8 | 1.0 | 1.1 |
| Condit. Reinf. lever presses | 0.8 | 1.1 | 2.0 | 1.0 | 0.9 | 0.7 | 1.4 | 1.4 | 1.1 | 1.0 | 1.0 | 0.7 | 0.9 | 1.1 |
| Time in novel zone, hab. session 2 | 0.8 | 0.8 | 1.8 | 0.7 | 0.6 | 1.0 | 1.3 | 1.3 | 0.6 | 0.4 | 0.9 | 1.0 | 0.6 | 0.6 |
| Bone: cortical area | 0.8 | 1.2 | 1.8 | 1.3 | 1.1 | 0.8 | 1.2 | 0.8 | 1.3 | 0.9 | 1.3 | 0.8 | 1.1 | 1.3 |
| Bone: stiffness | 0.8 | 1.3 | 2.9 | 1.1 | 1.1 | 0.7 | 1.7 | 1.1 | 1.2 | 0.7 | 1.5 | 0.6 | 1.2 | 1.3 |
| Heart weight | 0.7 | 1.0 | 2.0 | -1.1 | -1.2 | -0.9 | 0.1 | 0.8 | -1.2 | -0.8 | -1.4 | -0.6 | -1.1 | -1.2 |
| Mean time between licks in bursts | 0.7 | 0.9 | 3.5 | 0.9 | 0.9 | 1.0 | -0.5 | 0.7 | 0.8 | 1.9 | 0.1 | 1.2 | 0.9 | 0.8 |
| Locomotor activity | 0.7 | 1.1 | 2.4 | -1.0 | -1.2 | -0.6 | -1.4 | -0.6 | -1.1 | -0.2 | -1.5 | -0.6 | -1.2 | -1.3 |
| Cocaine response after cond. corrected | 0.7 | 0.8 | 2.3 | -0.9 | -1.0 | -0.3 | -0.5 | 0.3 | -1.2 | -0.5 | -1.5 | -0.4 | -1.0 | -1.2 |
| Progressive ratio test 2 inactive lever presses | 0.7 | 0.8 | 1.8 | -1.0 | -0.8 | -1.1 | 1.3 | 0.9 | -0.8 | -1.1 | -0.3 | -0.7 | -0.8 | -0.8 |
| Short access total infusions | 0.7 | 0.8 | 2.1 | -0.9 | -0.7 | -0.6 | 1.3 | 1.5 | -0.8 | -0.5 | -0.9 | -0.3 | -0.7 | -0.8 |
| Stereotopy head waving bouts, day 3 | 0.7 | 0.8 | 3.7 | -0.3 | -0.5 | 0.3 | 1.7 | 1.9 | -0.5 | -0.5 | -0.4 | 0.4 | -0.5 | -0.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.8 | 1.6 | 0.8 | 1.0 | 0.5 | 1.0 | 0.5 | 1.1 | 0.6 | 1.3 | 0.6 | 1.1 | 1.0 |
| Bone: elastic displacement | 0.7 | 0.7 | 1.9 | -0.7 | -0.7 | -0.4 | -1.4 | -1.1 | -0.8 | -0.4 | -1.2 | -0.6 | -0.8 | -0.8 |
| Bouts of movement, locomotor time 1 | 0.7 | 0.8 | 4.6 | 0.3 | 0.4 | 0.1 | -1.7 | -2.2 | 0.4 | 0.1 | 0.7 | 0.3 | 0.4 | 0.1 |
| Delay discounting water rate 18 sec | 0.6 | 0.7 | 2.5 | -0.8 | -0.9 | -0.2 | -0.5 | 0.6 | -1.0 | 0.1 | -1.6 | -0.7 | -1.0 | -1.1 |
| Cocaine response after cond. not corrected | 0.6 | 0.7 | 1.8 | -0.9 | -0.8 | -0.7 | -0.4 | 0.3 | -1.0 | -0.5 | -1.3 | -0.7 | -0.8 | -1.0 |
| Short access day 1 locomotion | 0.6 | 0.7 | 3.8 | -0.0 | 0.2 | 0.2 | 1.8 | 2.0 | 0.1 | 0.2 | -0.1 | 0.3 | 0.2 | 0.0 |
| Locomotion distance, session 1 | 0.6 | 0.8 | 2.1 | 0.8 | 0.6 | 1.3 | 0.9 | 1.4 | 0.5 | 1.0 | 0.3 | 1.0 | 0.6 | 0.6 |
| Time in familiar zone, hab. session 2 | 0.6 | 0.6 | 1.9 | -0.5 | -0.5 | -0.9 | -1.4 | -1.0 | -0.4 | 0.2 | -1.0 | -1.0 | -0.4 | -0.4 |
| Pavlov. Cond. response bias | 0.6 | 0.7 | 1.4 | 0.8 | 1.0 | 0.3 | 0.9 | 0.4 | 1.1 | 0.5 | 1.2 | 0.5 | 1.1 | 1.0 |
| Bone: cortical tissue density | 0.6 | 0.7 | 1.2 | 0.9 | 1.0 | 1.1 | -0.9 | -0.8 | 0.8 | 0.7 | 0.8 | 0.8 | 0.9 | 0.8 |
| Bone: elastic work | 0.6 | 0.8 | 1.7 | 1.0 | 0.9 | 1.3 | -0.3 | 0.0 | 0.9 | 1.3 | 0.3 | 1.1 | 0.9 | 0.9 |
| Bone: trabecular spacing | 0.6 | 0.7 | 2.9 | -0.5 | -0.8 | -0.7 | -1.7 | -1.3 | -0.5 | -0.1 | -0.9 | -0.6 | -0.6 | -0.5 |
| Delta time to tail flick, test, before/after SA | 0.6 | 0.6 | 3.3 | -0.2 | -0.1 | -0.4 | -1.5 | -1.8 | -0.1 | -0.5 | 0.2 | -0.4 | -0.1 | -0.2 |
| Change in fecal boli incidents, locomotor task | 0.6 | 0.6 | 1.8 | -0.7 | -0.9 | -0.1 | -0.4 | 0.5 | -0.9 | -0.1 | -1.4 | -0.1 | -0.9 | -1.0 |
| Run reversals in cocaine runway, males | 0.6 | 0.5 | 0.7 | -0.7 | -0.8 | -0.5 | -0.7 | -0.6 | -0.8 | -0.7 | -0.8 | -0.6 | -0.8 | -0.8 |
| Na content in liver | 0.6 | 0.6 | 1.1 | 0.9 | 0.7 | 0.6 | 0.9 | 0.6 | 0.9 | 0.5 | 1.1 | 0.5 | 0.8 | 1.0 |
| Indifference point 0 sec | 0.5 | 0.8 | 1.3 | 0.9 | 0.8 | 1.1 | 0.6 | 0.5 | 0.9 | 0.9 | 0.9 | 0.9 | 0.8 | 0.9 |
| Delay discounting total patch changes 0 sec | 0.5 | 0.7 | 1.5 | 0.9 | 0.8 | 1.2 | 0.2 | 0.2 | 0.9 | 1.1 | 0.7 | 1.0 | 0.8 | 0.9 |
| Delay discounting time to switch 0 sec | 0.5 | 0.8 | 3.2 | 0.6 | 0.8 | 0.4 | 1.8 | 1.2 | 0.6 | 0.2 | 1.0 | 0.7 | 0.9 | 0.7 |
| Reaction time number correct | 0.5 | 0.7 | 1.8 | 1.1 | 0.8 | 0.9 | -0.2 | 0.2 | 1.1 | 1.3 | 0.7 | 0.6 | 0.8 | 1.1 |
| Reaction time trials correct on left | 0.5 | 0.7 | 1.8 | 1.1 | 0.8 | 0.9 | -0.2 | 0.2 | 1.1 | 1.3 | 0.7 | 0.6 | 0.8 | 1.1 |
| Reaction time trials on left | 0.5 | 0.8 | 1.8 | 1.1 | 0.8 | 0.9 | -0.3 | 0.1 | 1.1 | 1.3 | 0.7 | 0.6 | 0.8 | 1.1 |
| Reaction time trials completed | 0.5 | 0.8 | 1.8 | 1.1 | 0.8 | 0.9 | -0.3 | 0.1 | 1.1 | 1.3 | 0.7 | 0.6 | 0.8 | 1.1 |
| Conditioned locomotion | 0.5 | 0.6 | 1.1 | 0.7 | 0.8 | 0.9 | 0.4 | 0.4 | 0.7 | 0.8 | 0.7 | 1.0 | 0.8 | 0.7 |
| Intermittent access day 15 total locomotion | 0.5 | 0.5 | 2.0 | -0.7 | -0.3 | -0.6 | 1.4 | 1.2 | -0.4 | -0.5 | 0.0 | -0.4 | -0.3 | -0.6 |
| Post-drug Anxiety | 0.5 | 0.6 | 1.6 | 0.8 | 0.9 | 0.6 | 0.3 | 0.0 | 0.9 | 0.6 | 1.3 | 0.6 | 0.9 | 0.9 |
| Pavlov. Cond. index score | 0.5 | 0.6 | 1.2 | 0.7 | 0.9 | 0.4 | 0.9 | 0.4 | 1.0 | 0.6 | 1.1 | 0.4 | 1.0 | 0.9 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.6 | -0.7 | -1.0 | -0.3 | -0.5 | 0.2 | -1.0 | -0.4 | -1.2 | -0.5 | -1.1 | -0.9 |
| Bone: cortical apparent density | 0.5 | 0.6 | 1.0 | 0.8 | 0.9 | 1.0 | -0.8 | -0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 |
| Bone: cortical thickness | 0.5 | 0.5 | 1.1 | 0.8 | 0.7 | 0.9 | -0.8 | -0.4 | 0.7 | 1.1 | 0.2 | 0.7 | 0.8 | 0.7 |
| Bone: periosteal estimation | 0.5 | 1.0 | 6.3 | -0.1 | -0.2 | -0.4 | 2.5 | 1.9 | -0.1 | -0.6 | 0.2 | -0.5 | -0.1 | -0.0 |
| Delta distance traveled before/after self-admin | 0.5 | 0.6 | 1.2 | -0.8 | -0.7 | -0.7 | -0.8 | -0.5 | -0.8 | -0.5 | -1.1 | -0.8 | -0.8 | -0.8 |
| Time to tail flick, vehicle, after self-admin | 0.5 | 0.5 | 1.2 | 0.7 | 0.5 | 0.9 | 0.7 | 1.1 | 0.6 | 0.9 | 0.2 | 0.8 | 0.6 | 0.6 |
| Delay disc. indifference point, 4s delay | 0.5 | 0.5 | 1.3 | 0.5 | 0.4 | 1.0 | 0.6 | 1.1 | 0.3 | 0.9 | 0.0 | 1.1 | 0.4 | 0.4 |
| Total resting periods, locomotor time 1 | 0.5 | 0.5 | 3.0 | 0.3 | 0.5 | 0.1 | -1.2 | -1.7 | 0.4 | 0.1 | 0.8 | 0.2 | 0.5 | 0.2 |
| Vertical activity count, locomotor time 1 | 0.5 | 0.5 | 1.0 | -0.9 | -0.8 | -0.8 | -0.1 | -0.0 | -0.8 | -0.7 | -0.8 | -0.8 | -0.7 | -1.0 |
| Total resting periods, locomotor time 2 | 0.5 | 0.6 | 1.1 | 0.9 | 0.9 | 0.7 | -0.0 | -0.2 | 0.8 | 0.7 | 0.8 | 0.7 | 0.8 | 1.1 |
| Epididymis fat weight | 0.4 | 0.8 | 2.1 | -0.7 | -1.0 | -1.1 | 1.2 | 1.5 | -0.5 | -0.5 | -0.6 | -0.9 | -0.9 | -0.5 |
| Water consumed over 24 hours | 0.4 | 0.5 | 0.9 | 0.9 | 0.7 | 0.9 | -0.4 | -0.3 | 0.8 | 0.9 | 0.6 | 0.6 | 0.7 | 0.9 |
| Delay discounting total patch changes 18 sec | 0.4 | 0.6 | 1.0 | 0.8 | 0.7 | 0.8 | 0.1 | -0.6 | 0.8 | 0.4 | 1.0 | 0.7 | 0.9 | 0.8 |
| Delay discounting water rate 0 sec | 0.4 | 0.7 | 1.2 | -0.7 | -0.7 | -0.5 | -1.1 | -0.8 | -0.8 | -0.4 | -1.0 | -1.0 | -0.9 | -0.9 |
| Reaction time mean minus median | 0.4 | 0.5 | 1.6 | 0.4 | 0.8 | -0.1 | -0.1 | -1.1 | 0.6 | -0.2 | 1.3 | 0.3 | 0.9 | 0.7 |
| Reaction time mean minus median AUC | 0.4 | 0.5 | 2.9 | 0.2 | 0.5 | -0.1 | -1.0 | -1.7 | 0.3 | -0.1 | 0.7 | 0.0 | 0.5 | 0.4 |
| Reaction time num false alarms | 0.4 | 0.6 | 2.4 | -0.6 | -0.6 | -0.1 | -1.5 | -0.6 | -0.7 | 0.1 | -1.3 | 0.1 | -0.7 | -0.7 |
| Std. dev. reaction times | 0.4 | 0.6 | 3.4 | -0.4 | -0.1 | -0.7 | -1.1 | -1.8 | -0.3 | -0.9 | 0.3 | -0.5 | 0.0 | -0.3 |
| Reaction time trials AUC | 0.4 | 0.6 | 1.6 | 1.0 | 0.7 | 0.8 | -0.2 | 0.2 | 0.9 | 1.3 | 0.6 | 0.5 | 0.7 | 1.0 |
| Pavlov. Cond. lever latency | 0.4 | 0.6 | 1.2 | -0.8 | -0.8 | -0.3 | -1.1 | -0.9 | -0.8 | -0.6 | -0.9 | -0.2 | -0.8 | -0.9 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.4 | 2.6 | 0.2 | 0.1 | -0.1 | 1.6 | 1.2 | 0.4 | -0.0 | 0.6 | -0.2 | 0.2 | 0.5 |
| Short access day 10 total locomotion | 0.4 | 0.4 | 2.5 | -0.1 | 0.2 | 0.2 | 1.5 | 1.6 | -0.0 | 0.1 | -0.0 | 0.1 | 0.1 | -0.0 |
| Context. condit. distance diff. score | 0.4 | 0.5 | 1.1 | -0.7 | -0.6 | -0.1 | 0.4 | 0.9 | -0.9 | -0.4 | -1.0 | -0.4 | -0.8 | -1.0 |
| Stereotopy head waving duration, day 3 | 0.4 | 0.5 | 1.7 | -0.4 | -0.6 | 0.4 | 1.0 | 1.3 | -0.7 | -0.4 | -0.3 | 0.4 | -0.6 | -0.7 |
| Degree of sensitization distance | 0.4 | 0.4 | 2.2 | -0.3 | -0.1 | 0.1 | 1.4 | 1.5 | -0.4 | -0.3 | -0.3 | 0.1 | -0.3 | -0.4 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 1.6 | 0.3 | 0.6 | -0.1 | 1.3 | 0.5 | 0.5 | -0.1 | 1.0 | 0.1 | 0.6 | 0.5 |
| Pavlov. Cond. latency score | 0.4 | 0.6 | 1.0 | 0.7 | 0.8 | 0.4 | 1.0 | 0.6 | 0.9 | 0.6 | 0.9 | 0.4 | 0.9 | 0.8 |
| Bone: apparent density | 0.4 | 0.7 | 2.3 | 0.5 | 0.9 | 0.6 | 1.5 | 1.4 | 0.5 | 0.4 | 0.6 | 0.4 | 0.8 | 0.6 |
| Time in closed arm after self-admin | 0.4 | 0.4 | 1.1 | -0.6 | -0.8 | -0.6 | -0.1 | 0.2 | -0.8 | -0.5 | -1.0 | -0.5 | -0.9 | -0.7 |
| Delay disc. indifference point, 0s delay | 0.4 | 0.4 | 1.6 | -0.5 | -0.6 | -0.1 | 0.8 | 1.3 | -0.6 | -0.1 | -0.9 | -0.1 | -0.6 | -0.5 |
| Distance moved, locomotor task time 2 | 0.4 | 0.5 | 0.7 | 0.7 | 0.8 | 0.5 | -0.6 | -0.6 | 0.8 | 0.7 | 0.8 | 0.6 | 0.8 | 0.5 |
| Latency to leave start box in cocaine runway | 0.4 | 0.4 | 0.8 | -0.6 | -0.6 | -0.6 | 0.9 | 0.9 | -0.5 | -0.4 | -0.4 | -0.5 | -0.6 | -0.6 |
| Se content in liver | 0.4 | 0.5 | 2.2 | 0.4 | 0.5 | 0.1 | 1.3 | 0.6 | 0.6 | -0.1 | 1.5 | 0.4 | 0.5 | 0.6 |
| Liver weight, left | 0.3 | 0.5 | 1.0 | -0.7 | -0.7 | -0.6 | -0.5 | -0.5 | -0.8 | -0.5 | -1.0 | -0.8 | -0.8 | -0.7 |
| Light reinforcement 2 | 0.3 | 0.5 | 1.4 | -0.4 | -0.4 | -1.0 | 1.1 | 0.1 | -0.2 | -1.2 | 0.5 | -0.9 | -0.3 | -0.1 |
| Reaction time num false alarms AUC | 0.3 | 0.4 | 2.6 | 0.0 | -0.1 | 0.6 | -1.6 | -0.7 | -0.1 | 0.6 | -0.7 | 0.7 | -0.2 | -0.2 |
| Reaction time mean AUC | 0.3 | 0.3 | 1.0 | -0.5 | -0.1 | -0.9 | -0.3 | -1.0 | -0.3 | -0.9 | 0.1 | -0.9 | -0.0 | -0.3 |
| Reaction time omissions | 0.3 | 0.4 | 2.2 | 0.1 | 0.3 | 0.2 | -1.3 | -1.5 | 0.0 | -0.1 | 0.2 | 0.3 | 0.5 | 0.0 |
| Reaction time false alarm rate | 0.3 | 0.5 | 1.3 | -0.6 | -0.5 | -0.1 | -1.1 | -0.4 | -0.7 | -0.2 | -1.1 | 0.2 | -0.7 | -0.8 |
| Cocaine response before conditioning | 0.3 | 0.4 | 0.8 | 0.5 | 0.7 | -0.5 | 0.2 | -0.4 | 0.9 | 0.3 | 0.9 | -0.3 | 0.7 | 0.9 |
| Condit. Reinf. active minus inactive responses | 0.3 | 0.4 | 0.9 | -0.6 | -0.6 | -0.8 | 0.1 | -0.6 | -0.5 | -1.0 | -0.1 | -1.0 | -0.6 | -0.5 |
| Pavlov. Cond. lever contacts | 0.3 | 0.4 | 0.7 | 0.7 | 0.8 | 0.1 | 0.3 | 0.0 | 0.8 | 0.5 | 0.9 | 0.1 | 0.8 | 0.8 |
| Locomotion distance, session 8 | 0.3 | 0.5 | 1.7 | -0.6 | -0.6 | 0.1 | 1.0 | 1.3 | -0.7 | -0.4 | -0.7 | -0.1 | -0.7 | -0.8 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.4 | 0.6 | 0.6 | 0.7 | 0.8 | -0.4 | -0.3 | 0.6 | 0.7 | 0.6 | 0.5 | 0.7 | 0.6 |
| Condit. Reinf. inactive responses | 0.3 | 0.3 | 2.0 | -0.1 | 0.0 | -0.6 | 1.4 | 0.9 | 0.1 | -0.4 | 0.4 | -0.3 | -0.0 | 0.1 |
| Total locomotion distance, hab. session 2 | 0.3 | 0.3 | 1.7 | 0.4 | 0.2 | 0.6 | 1.0 | 1.3 | 0.3 | 0.5 | -0.1 | 0.4 | 0.2 | 0.3 |
| Pavlov. Cond. lever contacts | 0.3 | 0.3 | 0.9 | 0.5 | 0.6 | 0.2 | 1.0 | 0.8 | 0.6 | 0.5 | 0.5 | 0.2 | 0.6 | 0.5 |
| Bone: maximum diameter | 0.3 | 0.5 | 2.8 | 0.5 | 0.3 | 0.2 | 1.7 | 1.0 | 0.5 | -0.1 | 0.9 | 0.2 | 0.4 | 0.5 |
| Bone: trabecular thickness | 0.3 | 0.4 | 1.0 | -0.7 | -0.2 | -0.7 | 0.5 | 0.1 | -0.6 | -1.0 | -0.5 | -0.9 | -0.3 | -0.6 |
| Distance traveled after self-admin | 0.3 | 0.3 | 0.6 | 0.6 | 0.6 | 0.3 | -0.0 | -0.4 | 0.7 | 0.4 | 0.8 | 0.1 | 0.7 | 0.8 |
| Delay disc. indifference point, 2s delay | 0.3 | 0.3 | 0.8 | -0.5 | -0.5 | -0.4 | 0.9 | 0.9 | -0.5 | -0.5 | -0.5 | -0.5 | -0.5 | -0.4 |
| Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 0.8 | -0.5 | -0.7 | -0.1 | -0.4 | 0.1 | -0.7 | -0.1 | -0.9 | -0.0 | -0.7 | -0.6 |
| Fecal boli incidents, locomotor time 1 | 0.3 | 0.4 | 1.2 | -0.5 | -0.3 | -0.9 | 0.5 | -0.4 | -0.4 | -1.1 | 0.2 | -1.0 | -0.3 | -0.3 |
| Distance moved, locomotor task time 1 | 0.3 | 0.3 | 0.6 | 0.5 | 0.5 | 0.4 | 0.6 | 0.8 | 0.5 | 0.6 | 0.4 | 0.4 | 0.6 | 0.3 |
| Vertical activity count, locomotor time 2 | 0.3 | 0.3 | 2.0 | -0.0 | -0.1 | 0.1 | -1.4 | -1.1 | -0.1 | 0.3 | -0.4 | 0.1 | -0.1 | -0.3 |
| Right kidney weight | 0.2 | 0.6 | 1.9 | 0.6 | 0.6 | 0.4 | 1.4 | 1.0 | 0.6 | -0.1 | 0.9 | 0.5 | 0.6 | 0.7 |
| Intraocular pressure | 0.2 | 0.2 | 0.9 | -0.3 | -0.3 | -0.5 | -0.8 | -1.0 | -0.2 | -0.4 | 0.4 | -0.4 | -0.3 | -0.1 |
| Times rat made contact with spout | 0.2 | 0.2 | 0.6 | 0.4 | 0.3 | 0.7 | -0.8 | -0.5 | 0.3 | 0.7 | 0.1 | 0.5 | 0.3 | 0.3 |
| Std. dev. time between licks in bursts | 0.2 | 0.3 | 1.0 | -0.4 | -0.3 | -0.2 | -0.9 | 0.1 | -0.5 | 0.5 | -1.0 | -0.3 | -0.3 | -0.4 |
| Light reinforcement 1 | 0.2 | 0.3 | 1.2 | -0.2 | -0.5 | -0.4 | -0.9 | -1.1 | -0.2 | -0.2 | -0.3 | -0.7 | -0.4 | -0.1 |
| Reaction time mean | 0.2 | 0.3 | 1.0 | -0.4 | 0.1 | -0.7 | -0.4 | -1.0 | -0.2 | -0.8 | 0.2 | -0.6 | 0.1 | -0.3 |
| Social responses | 0.2 | 0.2 | 0.9 | 0.4 | 0.2 | 0.3 | -0.9 | -0.9 | 0.3 | 0.5 | 0.0 | 0.1 | 0.1 | 0.4 |
| Social time | 0.2 | 0.2 | 1.2 | 0.2 | -0.2 | 0.3 | -1.1 | -0.9 | 0.0 | 0.2 | -0.2 | 0.1 | -0.3 | 0.1 |
| Condit. Reinf. inactive responses | 0.2 | 0.3 | 1.0 | 0.6 | 0.3 | 0.5 | -0.9 | -0.4 | 0.5 | 1.0 | -0.3 | -0.0 | 0.3 | 0.5 |
| Intermittent access intake escalation 2 | 0.2 | 0.2 | 0.9 | -0.1 | 0.0 | -0.4 | -0.5 | -0.9 | -0.0 | -0.5 | 0.5 | -0.3 | 0.1 | -0.0 |
| Intermitt. access escalation Index | 0.2 | 0.2 | 0.8 | -0.3 | -0.3 | -0.1 | 0.1 | 0.5 | -0.4 | -0.1 | -0.9 | -0.2 | -0.4 | -0.4 |
| Cocaine induced anxiety | 0.2 | 0.2 | 0.7 | 0.5 | 0.5 | 0.3 | 0.4 | 0.2 | 0.5 | 0.3 | 0.8 | 0.4 | 0.5 | 0.5 |
| Incentive Sensitization - Responses | 0.2 | 0.2 | 1.3 | 0.1 | 0.3 | -0.0 | 1.1 | 0.8 | 0.3 | 0.0 | 0.6 | 0.1 | 0.3 | 0.3 |
| Incentive Sensitization - Breakpoint | 0.2 | 0.2 | 1.3 | 0.0 | 0.2 | -0.2 | 1.2 | 0.8 | 0.2 | -0.1 | 0.5 | -0.1 | 0.2 | 0.2 |
| Locomotion distance, session 2 | 0.2 | 0.3 | 1.0 | 0.6 | 0.3 | 1.0 | 0.0 | 0.4 | 0.4 | 0.7 | 0.1 | 1.0 | 0.3 | 0.4 |
| Locomotion velocity, session 7 | 0.2 | 0.2 | 0.9 | -0.1 | -0.3 | 0.1 | 0.9 | 0.9 | -0.3 | -0.4 | -0.1 | 0.1 | -0.2 | -0.2 |
| Locomotion distance, session 7 | 0.2 | 0.3 | 1.0 | -0.4 | -0.4 | 0.2 | 0.5 | 1.0 | -0.5 | -0.1 | -0.8 | 0.1 | -0.4 | -0.5 |
| Stereotopy head waving bouts, day 7 | 0.2 | 0.3 | 1.1 | 0.3 | 0.3 | 0.4 | 1.0 | 0.6 | 0.3 | -0.2 | 0.8 | 0.4 | 0.2 | 0.2 |
| Locomotion velocity, session 8 | 0.2 | 0.2 | 0.7 | -0.2 | -0.3 | 0.5 | -0.8 | -0.2 | -0.4 | 0.2 | -0.6 | 0.3 | -0.3 | -0.5 |
| Total zone transitions, hab. session 1 | 0.2 | 0.3 | 1.0 | 0.7 | 0.6 | 1.0 | -0.1 | -0.1 | 0.6 | 0.5 | 0.5 | 0.8 | 0.5 | 0.5 |
| Total locomotion distance, hab. session 1 | 0.2 | 0.2 | 0.9 | -0.2 | -0.3 | 0.2 | 0.9 | 0.8 | -0.4 | -0.6 | -0.3 | -0.0 | -0.4 | -0.4 |
| Locomotion velocity, hab. session 2 | 0.2 | 0.3 | 1.6 | 0.2 | -0.0 | 0.5 | 1.1 | 1.3 | 0.1 | 0.2 | -0.1 | 0.3 | 0.0 | 0.2 |
| Bone: cortical porosity | 0.2 | 0.2 | 1.0 | -0.2 | -0.2 | 0.1 | -0.8 | -1.0 | -0.2 | -0.4 | -0.2 | 0.0 | -0.2 | -0.4 |
| Bone: cortical porosity | 0.2 | 0.2 | 1.0 | 0.1 | 0.2 | 0.4 | -0.9 | -1.0 | 0.1 | 0.0 | 0.1 | 0.4 | 0.2 | -0.0 |
| Bone: periosteal perimeter | 0.2 | 0.4 | 2.6 | 0.0 | -0.1 | -0.4 | 1.6 | 1.0 | 0.0 | -0.5 | 0.2 | -0.4 | -0.0 | 0.1 |
| Bone: tissue strength | 0.2 | 0.2 | 0.7 | -0.4 | -0.4 | -0.8 | -0.3 | -0.2 | -0.2 | -0.1 | -0.2 | -0.8 | -0.5 | -0.1 |
| Time in open arm after self-admin | 0.2 | 0.2 | 1.0 | 0.1 | 0.1 | 0.4 | -1.0 | -0.9 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | -0.0 |
| Ambulatory time after self-admin | 0.2 | 0.3 | 0.6 | 0.4 | 0.6 | 0.0 | 0.6 | 0.2 | 0.6 | 0.1 | 0.8 | -0.2 | 0.6 | 0.6 |
| Delay disc. indifference point, 16s delay | 0.2 | 0.2 | 1.2 | 0.3 | 0.3 | 0.2 | 1.1 | 0.9 | 0.3 | 0.1 | 0.4 | 0.2 | 0.3 | 0.4 |
| Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.7 | -0.4 | -0.2 | -0.7 | -0.2 | -0.8 | -0.2 | -0.7 | 0.3 | -0.7 | -0.2 | -0.4 |
| Seeking ratio, punishment vs. effort | 0.2 | 0.2 | 0.9 | -0.3 | -0.4 | 0.3 | -0.9 | -0.4 | -0.5 | 0.1 | -0.8 | 0.3 | -0.3 | -0.5 |
| Cu content in liver | 0.2 | 0.3 | 0.7 | 0.5 | 0.4 | 0.8 | -0.5 | -0.1 | 0.4 | 0.8 | 0.4 | 0.8 | 0.4 | 0.4 |
| Left kidney weight | 0.1 | 0.2 | 1.0 | 0.3 | 0.1 | 0.0 | 1.0 | 1.0 | 0.3 | -0.0 | 0.4 | 0.3 | 0.2 | 0.4 |
| Liver weight, right | 0.1 | 0.2 | 0.9 | 0.1 | -0.0 | 0.1 | 0.8 | 0.9 | -0.0 | 0.3 | -0.6 | -0.1 | -0.0 | 0.1 |
| Food consumed during 24 hour testing period | 0.1 | 0.1 | 0.5 | -0.3 | -0.2 | -0.5 | 0.1 | -0.4 | -0.2 | -0.4 | -0.0 | -0.7 | -0.2 | -0.1 |
| Mean num. licks in bursts | 0.1 | 0.1 | 0.7 | -0.2 | -0.0 | -0.1 | -0.8 | -0.7 | -0.2 | 0.1 | -0.4 | -0.1 | -0.1 | -0.2 |
| Median of all reaction times | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | -0.4 | 0.0 | -0.3 | -0.1 | -0.5 | 0.2 | -0.3 | 0.3 | -0.1 |
| Social response proportion | 0.1 | 0.1 | 0.4 | 0.5 | 0.4 | 0.1 | 0.2 | 0.1 | 0.5 | 0.6 | 0.3 | 0.2 | 0.2 | 0.6 |
| Condit. Reinf. lever reinforcers received | 0.1 | 0.1 | 0.3 | 0.4 | 0.3 | 0.2 | 0.1 | -0.4 | 0.5 | 0.2 | 0.5 | -0.1 | 0.3 | 0.5 |
| Progressive ratio test 1 inactive lever presses | 0.1 | 0.1 | 0.6 | 0.1 | 0.2 | 0.3 | 0.7 | 0.8 | 0.1 | 0.3 | -0.0 | 0.5 | 0.1 | 0.1 |
| Locomotion velocity, session 1 | 0.1 | 0.1 | 0.3 | -0.1 | -0.0 | 0.5 | -0.1 | 0.5 | -0.2 | 0.4 | -0.4 | 0.2 | -0.2 | -0.3 |
| Locomotion distance, session 3 | 0.1 | 0.1 | 0.4 | 0.3 | -0.1 | 0.3 | 0.2 | 0.6 | 0.3 | 0.6 | -0.1 | 0.2 | 0.2 | 0.3 |
| Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.5 | 0.1 | 0.4 | -0.2 | 0.6 | 0.7 | 0.3 | 0.4 | -0.1 | -0.1 | 0.3 | 0.3 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.2 | 0.6 | 0.3 | 0.3 | 0.7 | 0.8 | 0.6 | 0.2 | -0.0 | 0.3 | 0.6 | 0.2 | 0.2 |
| Total locomotion distance, NPP test | 0.1 | 0.2 | 0.6 | 0.2 | 0.0 | 0.6 | 0.5 | 0.8 | 0.0 | 0.3 | -0.2 | 0.6 | 0.1 | 0.1 |
| Locomotion velocity, NPP test | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | 0.6 | 0.2 | 0.4 | -0.1 | 0.1 | -0.2 | 0.5 | -0.0 | -0.0 |
| Pavlov. Cond. intertrial magazine entries | 0.1 | 0.2 | 0.9 | 0.1 | 0.2 | -0.1 | -0.5 | -1.0 | 0.1 | -0.3 | 0.6 | 0.2 | 0.0 | 0.2 |
| Time in closed arm before self-admin | 0.1 | 0.1 | 0.3 | -0.1 | 0.0 | -0.5 | 0.5 | 0.0 | 0.0 | -0.5 | 0.3 | -0.5 | -0.1 | 0.1 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.3 | -0.4 | -0.3 | -0.3 | -0.3 | -0.1 |
| Area under the delay curve | 0.1 | 0.1 | 0.7 | 0.1 | 0.0 | 0.3 | 0.7 | 0.8 | -0.0 | 0.2 | -0.2 | 0.3 | 0.0 | 0.1 |
| Delay disc. indifference point, 24s delay | 0.1 | 0.1 | 0.6 | 0.3 | 0.2 | 0.5 | -0.0 | 0.4 | 0.2 | 0.7 | -0.1 | 0.4 | 0.2 | 0.2 |
| Delay discount exponential model param | 0.1 | 0.1 | 0.6 | -0.1 | -0.0 | -0.3 | -0.6 | -0.8 | 0.0 | -0.2 | 0.2 | -0.3 | -0.0 | -0.1 |
| Delay discount hyperbolic model param | 0.1 | 0.1 | 0.7 | -0.1 | -0.0 | -0.3 | -0.7 | -0.9 | 0.0 | -0.3 | 0.1 | -0.4 | -0.0 | -0.1 |
| Progressive ratio | 0.1 | 0.2 | 0.8 | 0.2 | 0.2 | -0.2 | 0.9 | 0.7 | 0.3 | 0.1 | 0.4 | -0.4 | -0.0 | 0.4 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.4 | -0.2 | -0.3 | 0.0 | -0.3 | -0.0 | -0.4 | -0.0 | -0.7 | -0.2 | -0.4 | -0.2 |
| Number of licking bursts | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | 0.2 | 0.2 | -0.0 | 0.0 | 0.1 | 0.0 | -0.0 | 0.1 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | -0.0 | 0.0 | -0.3 | 0.2 | -0.0 | 0.2 | -0.4 | -0.0 | 0.2 |
| Number of responses in last shaping day | 0.0 | 0.0 | 0.2 | -0.1 | -0.0 | 0.1 | -0.2 | 0.1 | -0.2 | 0.1 | -0.4 | 0.3 | -0.1 | -0.2 |
| Delta time to tail flick, vehicle, before/after SA | 0.0 | 0.0 | 0.2 | 0.1 | -0.0 | 0.2 | -0.4 | -0.1 | -0.0 | 0.4 | -0.3 | 0.1 | 0.0 | -0.1 |
| Seeking ratio, delayed vs. immediate footshock | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.4 | 0.3 | 0.0 | 0.1 | -0.1 | 0.1 | 0.1 | 0.3 |
| Latency to leave start box in cocaine runway, F | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | 0.0 | 0.5 | 0.4 | 0.1 | 0.1 | 0.2 | 0.1 | 0.0 | 0.1 |
| Fe content in liver | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.1 | 0.2 | 0.0 | -0.1 | -0.3 | 0.2 | 0.1 | -0.1 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.