Hub : Genes

Fads3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000020385	0.05	0.03	1.7e-06	0.02	0.02	0.03	0.02	5.8e-03	9.7e-04	5.3e-04	5.9e-03
2	BLA	gene expression	ENSRNOG00000020385	0.35	0.18	9.8e-05	0.05	0.07	0.07	0.07	1.2e-03	1.7e-04	8.6e-05	1.5e-04
3	Brain	gene expression	ENSRNOG00000020385	0.12	0.07	1.9e-09	0.07	0.1	0.1	0.1	2.0e-07	1.8e-09	6.0e-10	1.6e-09
4	IL	gene expression	ENSRNOG00000020385	0.16	0.11	1.5e-03	0.09	0.09	0.03	0.09	3.1e-03	3.0e-03	5.3e-02	3.8e-03
5	Liver	isoform ratio	ENSRNOT00000100217	0.03	0.02	7.3e-03	0.01	0	-0	-0	3.7e-02	3.5e-01	5.4e-01	4.0e-01
6	NAcc	gene expression	ENSRNOG00000020385	0.19	0.1	2.1e-14	0.21	0.2	0.19	0.2	2.4e-15	1.1e-14	4.2e-14	1.9e-14
7	PL	gene expression	ENSRNOG00000020385	0.15	0.09	6.2e-09	0.12	0.12	0.12	0.12	2.1e-09	2.7e-09	2.8e-09	2.2e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	3.0	9.6	15.3	2.0	-3.9	-3.9	-2.7	2.9	-2.8	-3.0
BMI without tail	1.6	3.4	4.2	1.4	-2.0	-2.0	-1.7	1.8	-1.9	-2.0
Body weight	3.6	15.3	19.4	2.7	-3.2	-4.4	-3.9	4.2	-4.2	-4.4
Epididymis fat weight	0.5	1.1	2.4	-1.5	-1.5	-0.1	1.1	-0.9	0.9	0.8
Glucose	2.3	3.5	5.4	-2.3	0.5	1.3	2.2	-2.0	2.0	2.1
Heart weight	0.4	0.5	1.4	-1.2	-0.4	0.4	0.9	-0.6	0.6	0.5
Left kidney weight	0.2	0.4	1.5	-0.5	-1.2	-0.9	-0.1	0.4	-0.4	-0.5
Right kidney weight	0.2	0.5	1.3	-0.1	-1.1	-1.0	-0.4	0.6	-0.5	-0.6
Tail length	0.8	2.6	4.2	1.4	-0.2	-1.1	-1.8	1.9	-2.0	-2.0
Length with tail	1.9	7.0	9.7	1.9	-1.4	-2.7	-2.8	3.0	-3.0	-3.1
Length without tail	1.3	2.9	4.0	1.0	-0.9	-2.0	-1.8	2.0	-1.9	-1.9
Liver weight, left	0.6	0.9	1.6	-1.2	1.0	1.0	0.9	-0.8	0.8	0.8
Liver weight, right	0.0	0.1	0.3	-0.5	-0.1	0.1	0.2	-0.2	0.2	0.1
Parametrial fat weight	1.5	2.9	4.9	-2.2	-1.1	0.4	2.0	-1.8	1.8	1.9
Retroperitoneal fat weight	1.9	6.2	13.3	-3.6	-0.5	1.5	3.0	-2.5	2.5	2.5
Intraocular pressure	0.1	0.1	0.2	0.3	0.4	0.4	0.3	-0.4	0.4	0.4
Extensor digitorum longus weight	5.8	23.3	26.7	4.7	-3.2	-5.2	-5.1	5.1	-5.1	-5.1
Soleus weight	2.6	7.7	9.0	-2.7	1.9	2.9	3.0	-2.9	2.9	3.0
Tibialis anterior weight	9.0	31.0	38.1	5.8	-1.8	-5.3	-6.2	6.2	-6.2	-6.1
Tibia length	1.0	2.7	4.1	1.4	-0.6	-2.0	-1.9	1.8	-1.8	-1.8
Number of licking bursts	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.1	0.0	-0.0	0.1
Food consumed during 24 hour testing period	0.4	0.5	0.8	-0.6	0.6	0.9	0.6	-0.7	0.7	0.8
Times rat made contact with spout	0.2	0.2	0.3	0.5	0.3	0.0	-0.4	0.5	-0.5	-0.5
Mean time between licks in bursts	0.9	1.2	1.6	1.3	-0.9	-1.0	-1.1	1.2	-1.1	-1.1
Mean num. licks in bursts	0.1	0.1	0.4	0.2	0.5	0.7	-0.0	-0.1	0.1	0.0
Std. dev. time between licks in bursts	0.1	0.2	0.4	-0.6	-0.4	0.3	0.4	-0.3	0.3	0.3
Water consumed over 24 hours	0.2	0.2	0.4	0.3	-0.3	-0.2	-0.6	0.6	-0.6	-0.6
Indifference point 0 sec	0.5	0.7	1.2	0.7	-0.2	-0.8	-1.0	1.1	-1.1	-0.8
Indifference point AUC	1.3	1.5	2.1	1.4	0.1	-1.1	-1.5	1.3	-1.3	-1.4
Indifference point function ln k	2.4	3.4	4.8	-2.1	-1.0	1.2	2.2	-1.9	2.0	2.2
Indifference point function log k	2.4	3.4	4.8	-2.1	-1.0	1.2	2.2	-1.9	2.0	2.2
Delay discounting total patch changes 0 sec	0.4	0.7	1.2	0.7	-0.1	-0.7	-1.0	1.1	-1.1	-0.9
Delay discounting total patch changes 12 sec	5.6	7.5	9.9	2.9	-0.4	-2.3	-3.1	3.1	-3.1	-3.0
Delay discounting total patch changes 18 sec	0.4	0.6	0.8	0.7	0.7	-0.3	-0.9	0.9	-0.9	-0.8
Delay discounting total patch changes 24 sec	6.8	8.5	10.6	2.6	-1.6	-3.0	-3.1	3.2	-3.2	-3.3
Delay discounting total patch changes 6 sec	0.8	1.3	2.1	0.7	-0.3	-1.2	-1.2	1.5	-1.5	-1.1
Delay discounting time to switch 0 sec	0.3	0.5	1.1	0.4	-0.7	-1.0	-0.6	0.7	-0.7	-0.5
Delay discounting water rate 0 sec	0.6	0.9	1.7	-0.9	0.8	1.3	0.9	-1.0	1.0	0.9
Delay discounting water rate 12 sec	1.2	1.8	2.3	-1.4	0.1	1.4	1.5	-1.5	1.5	1.5
Delay discounting water rate 18 sec	0.5	0.7	1.8	-1.3	-0.6	0.8	0.9	-0.6	0.6	0.7
Delay discounting water rate 24 sec	1.0	1.4	1.9	-1.2	0.2	1.4	1.4	-1.1	1.1	1.4
Delay discounting water rate 6 sec	0.7	1.1	1.7	-1.3	0.1	1.2	1.2	-1.1	1.0	0.9
Locomotor activity	0.5	0.8	1.3	-1.1	1.1	1.2	0.9	-0.6	0.6	0.5
Locomotor testing distance	0.4	0.7	1.1	-1.0	0.9	1.0	0.9	-0.6	0.6	0.6
Locomotor testing rearing	0.7	1.1	1.9	-0.9	0.8	1.4	1.1	-1.1	1.1	1.1
Light reinforcement 1	0.4	0.7	2.0	-0.6	1.4	1.1	0.5	-0.6	0.6	0.6
Light reinforcement 2	0.5	0.7	1.5	-1.2	-0.2	0.4	0.8	-0.9	0.9	0.9
Reaction time number correct	0.2	0.3	0.7	0.3	0.1	-0.1	-0.7	0.6	-0.6	-0.8
Reaction time mean minus median	0.3	0.4	1.3	1.1	0.6	-0.4	-0.6	0.4	-0.4	-0.3
Reaction time mean minus median AUC	0.3	0.4	1.3	1.1	1.2	0.2	-0.4	0.1	-0.2	-0.0
Reaction time num false alarms	0.2	0.2	0.9	-0.4	0.9	0.7	0.3	0.1	-0.1	0.0
Reaction time num false alarms AUC	0.3	0.4	0.8	0.0	0.9	0.3	-0.3	0.7	-0.7	-0.6
Reaction time trials correct on left	0.2	0.3	0.7	0.3	0.1	-0.1	-0.7	0.6	-0.6	-0.8
Reaction time trials on left	0.2	0.3	0.7	0.3	0.2	-0.0	-0.7	0.6	-0.6	-0.8
Reaction time mean	0.2	0.2	0.5	0.7	0.5	0.1	0.0	-0.5	0.5	0.5
Reaction time mean AUC	0.3	0.4	0.7	0.5	0.4	0.3	0.3	-0.8	0.8	0.8
Median of all reaction times	0.1	0.1	0.4	0.6	-0.1	-0.2	-0.1	-0.3	0.3	0.3
Reaction time omissions	0.2	0.2	1.0	0.5	1.0	0.2	-0.3	0.3	-0.3	-0.2
Reaction time false alarm rate	0.1	0.1	0.3	-0.3	0.6	0.3	0.2	0.2	-0.2	0.0
Reaction time premature initiation rate	3.4	4.5	5.7	1.2	-1.9	-2.4	-2.2	2.3	-2.3	-2.3
Reaction time premature initiations	3.7	5.3	7.6	1.6	-1.4	-2.2	-2.5	2.6	-2.6	-2.8
Std. dev. reaction times	0.3	0.4	1.7	0.7	1.3	0.5	0.1	-0.4	0.4	0.6
Reaction time trials completed	0.2	0.3	0.7	0.3	0.2	-0.0	-0.7	0.6	-0.6	-0.8
Reaction time trials AUC	0.2	0.2	0.6	0.2	0.1	0.0	-0.6	0.5	-0.5	-0.7
Social response proportion	0.1	0.1	0.6	-0.8	0.2	0.2	-0.1	0.3	-0.3	-0.2
Social responses	0.2	0.2	1.0	-0.4	1.0	0.7	-0.1	0.2	-0.2	-0.1
Social time	0.2	0.2	0.7	0.2	0.9	0.6	-0.2	0.2	-0.2	-0.3
Conditioned locomotion	0.7	0.8	1.1	0.9	-0.4	-1.0	-0.9	1.0	-1.0	-1.0
Cocaine response after cond. corrected	0.2	0.2	0.3	0.0	-0.6	0.2	0.5	-0.4	0.4	0.6
Cocaine response after cond. not corrected	0.3	0.3	0.7	-0.1	-0.3	0.4	0.6	-0.7	0.7	0.8
Cocaine response before conditioning	0.1	0.1	0.6	0.1	0.8	0.3	-0.1	-0.3	0.3	0.2
Saline control response	1.8	2.4	3.3	1.6	-0.1	-1.2	-1.8	1.8	-1.8	-1.8
Condit. Reinf. active minus inactive responses	0.4	0.5	0.9	0.0	0.6	0.6	0.6	-0.9	0.9	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.1	-0.6	-0.1	0.6	-0.9	0.8	0.8
Condit. Reinf. active responses	0.1	0.1	0.1	0.1	0.3	0.3	0.1	-0.4	0.3	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.8	-0.5	0.9	0.8	0.0	-0.0	-0.0	-0.0
Condit. Reinf. lever presses	0.4	0.5	0.9	0.9	-0.6	-1.0	-0.8	0.6	-0.6	-0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.6	0.3	0.1	-0.2	-0.1	0.1	0.1
Pavlov. Cond. lever latency	0.3	0.5	1.1	-0.8	1.0	1.0	0.6	-0.3	0.3	0.3
Pavlov. Cond. magazine entry latency	3.8	4.4	7.8	2.8	-1.5	-2.2	-2.3	1.8	-1.8	-1.8
Pavlov. Cond. change in total contacts	0.6	0.8	2.3	1.5	-0.8	-1.1	-1.0	0.4	-0.4	-0.5
Pavlov. Cond. index score	1.9	2.5	4.7	2.2	-1.5	-1.9	-1.7	1.1	-1.1	-1.1
Pavlov. Cond. latency score	1.8	2.3	4.0	2.0	-1.6	-1.9	-1.6	1.1	-1.1	-1.1
Pavlov. Cond. lever contacts	0.3	0.4	1.6	1.3	-0.5	-0.7	-0.6	0.2	-0.2	-0.1
Pavlov. Cond. magazine entry number	6.0	7.4	12.1	-3.5	1.9	2.9	3.0	-2.5	2.5	2.5
Pavlov. Cond. intertrial magazine entries	1.8	2.3	2.9	-1.6	1.7	1.7	1.5	-1.3	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	5.3	2.3	-1.5	-1.9	-1.8	1.2	-1.2	-1.2
Pavlov. Cond. response bias	1.2	1.6	3.7	1.9	-1.1	-1.4	-1.4	0.9	-0.9	-0.9
Conditioned reinforcement - actives	2.0	2.0	3.0	-1.0	0.4	1.6	1.4	-1.7	1.6	1.7
Conditioned reinforcement - inactives	0.8	1.0	1.5	-0.8	-0.6	0.5	1.0	-1.2	1.2	1.2
Conditioned locomotion	1.4	1.6	2.3	-1.5	-0.5	0.9	1.4	-1.5	1.5	1.3
Intermittent access intake day 1-15 change	1.8	1.8	2.5	-0.8	1.6	1.6	1.1	-1.5	1.5	1.2
Intermittent access intake escalation	1.1	1.1	1.5	-0.5	1.2	1.2	0.8	-1.2	1.2	0.8
Intermittent access intake escalation 2	0.2	0.2	0.8	0.2	0.9	0.5	0.1	-0.4	0.5	0.2
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.2	-1.2	-1.2	0.3	1.2	-1.5	1.5	1.2
Intermitt. access day 15 inactive lever presses	0.5	0.5	2.6	-0.3	-1.6	-0.9	-0.1	-0.0	0.0	-0.0
Intermitt. access escalation Index	0.2	0.2	0.9	-1.0	-0.2	0.1	0.4	-0.2	0.2	-0.1
Intermittent access day 1 total infusions	0.7	0.8	2.3	-1.2	-1.5	-0.6	0.8	-0.6	0.7	0.7
Intermittent access day 15 total infusions	2.6	2.9	4.2	-1.9	0.3	1.3	1.9	-2.0	2.1	1.8
Intermittent access terminal intake (last 3 days)	0.5	0.5	0.9	-0.8	-0.3	0.1	0.8	-0.8	0.9	0.8
Intermittent access total infusions	0.6	0.7	1.1	-1.1	-0.3	0.1	0.9	-0.9	1.0	1.0
Intermittent access day 1 locomotion	0.9	0.9	4.7	-0.6	-2.2	-1.1	0.1	0.1	-0.1	-0.0
Intermittent access day 15 total locomotion	0.4	0.4	2.0	-0.1	-1.4	-0.9	0.1	-0.3	0.4	0.4
Intermittent access total locomotion	0.8	0.9	4.0	-0.6	-2.0	-1.2	0.2	-0.1	0.3	0.2
Intermittent access standard deviation	1.0	1.0	1.7	-0.0	0.5	1.1	0.9	-1.3	1.3	1.2
Cocaine induced anxiety	0.2	0.2	0.5	0.7	-0.2	-0.5	-0.6	0.3	-0.4	-0.2
Post-drug Anxiety	0.4	0.5	1.0	1.0	-0.4	-0.7	-0.8	0.6	-0.6	-0.5
Baseline Anxiety	1.0	1.1	1.8	1.0	-0.6	-0.9	-1.1	1.1	-1.1	-1.3
Lifetime Intake	0.5	0.6	0.9	-0.9	-0.7	-0.0	0.8	-0.8	0.8	0.8
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	-0.3	-0.3	-0.1	0.2	-0.1	-0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.0	0.1	-0.0	0.1
Progressive ratio test 1 active lever presses	1.2	1.2	1.8	-1.2	0.4	1.0	1.2	-1.3	1.2	1.1
Progressive ratio test 1 breakpoint	1.4	1.4	2.1	-1.2	0.5	1.1	1.3	-1.4	1.3	1.2
Progressive ratio test 1 inactive lever presses	0.7	0.7	2.2	0.4	-1.5	-1.2	-0.5	0.5	-0.5	-0.5
Progressive ratio test 2 active lever presses	1.2	1.2	1.7	-1.3	0.1	0.8	1.2	-1.3	1.3	1.2
Progressive ratio test 2 breakpoint	2.1	2.3	3.0	-1.7	0.6	1.3	1.6	-1.7	1.7	1.6
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.2	-0.8	-1.1	-0.1	0.7	-0.7	0.7	0.8
Total sessions with >9 infusions	0.9	1.0	1.3	-1.0	-1.0	0.2	1.1	-1.1	1.1	1.0
Short access day 1 total inactive lever presses	0.6	0.7	1.2	-1.1	-0.9	0.3	0.9	-0.9	0.8	0.7
Short access day 10 total inactive lever presses	1.4	1.5	2.2	-1.4	-0.1	1.1	1.5	-1.2	1.5	1.2
Short access day 1 total infusions	0.6	0.6	1.1	-0.7	-1.1	0.2	0.8	-0.7	0.7	0.9
Short access day 10 total infusions	0.5	0.5	2.1	-0.7	-1.5	-0.8	0.4	-0.3	0.2	0.2
Short access total infusions	0.4	0.4	1.9	-0.5	-1.4	-0.4	0.4	-0.3	0.3	0.3
Short access day 1 locomotion	1.0	1.1	5.5	0.3	-2.3	-1.1	-0.4	0.5	-0.4	-0.5
Short access day 10 total locomotion	0.8	0.9	4.9	-0.0	-2.2	-1.2	-0.1	0.2	-0.3	0.0
Short access total locomotion	1.6	1.7	6.9	0.4	-2.6	-1.7	-0.6	0.7	-0.6	-0.7
Compulsive drug intake	1.1	1.1	2.0	1.2	-0.0	-0.3	-1.1	1.4	-1.2	-1.2
One hour access (0.3 mA shock)	2.9	3.3	4.6	-2.0	0.2	1.4	2.1	-2.1	2.1	2.0
One hour access (shock baseline)	4.5	5.2	7.0	-2.3	1.1	1.8	2.5	-2.7	2.6	2.6
Number of responses in last shaping day	0.2	0.2	0.4	0.3	-0.6	-0.3	-0.4	0.2	-0.3	-0.6
Context. condit. distance diff. score	0.1	0.1	0.5	-0.1	-0.7	0.0	0.3	-0.3	0.3	0.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.3	0.2	-0.2	-0.2
Locomotion distance, session 1	0.8	1.1	1.3	1.1	-0.8	-1.0	-1.1	1.0	-1.0	-1.1
Locomotion velocity, session 2	2.9	3.4	4.0	1.8	-1.2	-2.0	-2.0	2.0	-2.0	-1.9
Locomotion distance, session 2	0.7	0.9	1.5	1.2	-0.4	-0.9	-1.0	1.0	-1.0	-1.1
Locomotion velocity, session 3	1.0	1.1	4.0	0.2	-2.0	-1.6	-0.5	0.7	-0.7	-0.5
Locomotion distance, session 3	0.1	0.1	0.4	-0.6	-0.1	0.1	0.0	0.1	-0.1	0.0
Stereotopy head waving bouts, day 3	0.4	0.4	1.5	-0.2	-1.2	-1.0	-0.1	0.4	-0.4	-0.4
Stereotopy head waving duration, day 3	0.3	0.4	1.2	0.1	-1.1	-0.9	-0.1	0.4	-0.4	-0.5
Locomotion velocity, session 7	0.0	0.0	0.1	-0.4	-0.2	-0.3	0.1	0.1	-0.1	-0.1
Locomotion distance, session 7	0.1	0.1	0.3	-0.5	-0.5	-0.2	0.2	0.1	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.5	-0.3	-0.7	-0.5	0.4	-0.4	-0.4
Stereotopy head waving duration, day 7	1.5	1.9	2.4	1.2	-0.5	-1.5	-1.6	1.5	-1.5	-1.6
Locomotion velocity, session 8	0.1	0.2	0.6	-0.0	0.8	0.3	-0.2	0.4	-0.4	-0.4
Locomotion distance, session 8	0.1	0.1	0.4	0.0	-0.6	-0.3	0.1	-0.1	0.1	-0.0
Degree of sensitization distance	0.4	0.4	2.0	0.4	-1.4	-1.0	-0.1	0.1	-0.1	-0.2
Degree of sensitization stereotypy	0.7	0.8	1.2	1.1	-0.4	-1.0	-1.1	0.8	-0.8	-0.8
Condit. Reinf. active minus inactive responses	0.8	0.8	1.9	1.4	-0.3	-0.8	-1.1	0.9	-0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	2.0	1.4	0.1	-0.2	-0.8	0.5	-0.5	-0.5
Condit. Reinf. active responses	0.7	0.8	1.6	1.3	-0.8	-1.1	-1.0	0.8	-0.8	-0.7
Condit. Reinf. inactive responses	0.2	0.2	0.8	-0.2	-0.9	-0.5	0.2	-0.3	0.3	0.4
Incentive salience index mean	0.7	0.9	1.1	0.9	-0.8	-1.0	-1.1	1.0	-1.0	-0.9
Condit. Reinf. lever presses	0.3	0.4	0.9	-0.1	-0.9	-0.8	-0.6	0.6	-0.6	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.1	-0.6	-0.1	-0.1	-0.1	0.1	0.1
Time in novel zone, hab. session 1	1.2	1.1	1.4	-0.9	0.8	1.2	1.2	-1.1	1.1	1.1
Total zone transitions, hab. session 1	0.4	0.6	0.7	0.8	0.8	-0.3	-0.8	0.8	-0.8	-0.8
Total locomotion distance, hab. session 1	0.0	0.1	0.2	0.2	-0.5	-0.4	0.0	-0.0	0.0	0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.7	0.8	-0.3	-0.8	-0.6	0.6	-0.6	-0.6
Time in familiar zone, hab. session 2	0.9	0.9	1.6	-0.7	0.8	1.2	0.9	-1.0	1.0	1.0
Time in novel zone, hab. session 2	0.9	0.9	1.3	0.7	-0.8	-1.1	-0.9	1.0	-1.0	-1.0
Total zone transitions, hab. session 2	0.9	1.2	1.7	0.9	-0.2	-0.8	-1.3	1.3	-1.3	-1.2
Total locomotion distance, hab. session 2	0.2	0.2	0.7	0.4	-0.8	-0.5	-0.4	0.4	-0.4	-0.3
Locomotion velocity, hab. session 2	0.1	0.2	0.7	0.2	-0.8	-0.5	-0.2	0.3	-0.3	-0.1
Novel to familiar place preference ratio	2.2	2.3	3.2	1.1	-0.8	-1.6	-1.6	1.8	-1.8	-1.7
Novelty place preference	1.4	1.5	2.0	0.8	-0.8	-1.3	-1.2	1.4	-1.4	-1.4
Time in novel zone, NPP test	1.7	1.8	2.2	1.1	-1.0	-1.5	-1.3	1.5	-1.5	-1.4
Total zone transitions, NPP test	1.2	1.7	2.5	1.4	0.3	-0.9	-1.5	1.5	-1.5	-1.6
Total locomotion distance, NPP test	0.2	0.2	0.4	0.3	0.0	-0.4	-0.5	0.6	-0.6	-0.6
Locomotion velocity, NPP test	0.1	0.2	0.3	0.0	0.5	-0.1	-0.4	0.5	-0.5	-0.5
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.3	0.7	0.8	0.9	-1.0	1.0	1.0
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	0.7	-0.8	-1.1	-0.9	0.6	-0.6	-0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.1	-0.3	-0.3	0.1	-0.1	-0.1
Pavlov. Cond. index score	0.1	0.2	0.3	0.4	-0.1	-0.4	-0.6	0.4	-0.4	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	0.1	-0.2	-0.3	-0.5	0.4	-0.4	-0.3
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.3	-0.2	-0.1	-0.2	0.2	-0.2	-0.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	-0.8	-0.1	0.4	0.7	-0.4	0.4	0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.8	0.2	1.7	0.5	-0.2	0.2	-0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.6	-0.1	-0.5	-0.7	0.6	-0.6	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	0.6	-0.3	-0.5	-0.7	0.5	-0.5	-0.5
Bone: apparent density	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.3	0.4	-0.4	-0.4
Bone surface	0.7	1.2	1.9	0.4	-0.6	-1.2	-1.3	1.3	-1.3	-1.4
Bone volume	0.1	0.3	0.4	-0.1	-0.3	-0.6	-0.6	0.5	-0.5	-0.6
Bone: connectivity density	1.0	1.6	2.1	0.7	-1.0	-1.3	-1.3	1.4	-1.4	-1.4
Bone: cortical apparent density	0.4	0.5	0.8	0.9	0.3	-0.3	-0.8	0.7	-0.7	-0.8
Bone: cortical area	0.3	0.4	0.7	0.3	0.4	-0.4	-0.8	0.8	-0.8	-0.7
Bone: cortical porosity	0.2	0.2	0.9	0.4	1.0	0.3	-0.1	0.1	-0.1	-0.1
Bone: cortical porosity	0.3	0.3	0.9	0.7	0.9	0.0	-0.5	0.5	-0.5	-0.5
Bone: cortical thickness	2.1	3.5	4.9	1.9	1.0	-0.9	-2.2	2.2	-2.2	-2.1
Bone: cortical thickness	0.3	0.4	0.5	0.5	0.7	0.1	-0.7	0.7	-0.7	-0.6
Bone: cortical tissue density	0.5	0.6	1.1	1.0	0.3	-0.4	-0.9	0.8	-0.8	-0.9
Bone: elastic displacement	0.5	0.5	1.4	-0.3	1.0	1.2	0.6	-0.6	0.6	0.5
Bone: elastic work	0.7	0.9	1.4	1.0	0.2	-0.2	-1.1	1.2	-1.2	-1.1
Bone: endosteal estimation	1.3	2.8	4.8	-2.2	-1.5	0.5	1.8	-1.7	1.7	1.7
Bone: endosteal perimeter	2.0	4.0	6.4	-2.5	-1.0	0.8	2.3	-2.2	2.2	2.3
Bone: final force	1.1	1.7	2.4	1.1	-0.5	-1.3	-1.5	1.5	-1.5	-1.5
Bone: final moment	1.0	1.6	2.2	1.0	-0.4	-1.2	-1.5	1.5	-1.5	-1.4
Bone: marrow area	1.4	3.0	5.4	-2.3	-1.4	0.6	1.9	-1.8	1.8	1.8
Bone: maximum diameter	0.0	0.1	0.2	-0.2	-0.3	-0.4	-0.2	0.2	-0.2	-0.1
Bone: maximum force	1.4	2.5	3.7	0.9	-1.3	-1.9	-1.7	1.7	-1.7	-1.7
Bone: maximum moment	1.3	2.3	3.3	0.9	-1.1	-1.8	-1.6	1.6	-1.6	-1.6
Bone: minimum diameter	0.8	1.5	3.1	-1.7	-1.0	0.2	1.3	-1.3	1.3	1.3
Bone: periosteal estimation	0.2	0.4	1.1	-1.1	-0.8	-0.1	0.5	-0.5	0.5	0.6
Bone: periosteal perimeter	0.1	0.2	0.4	-0.6	-0.1	0.1	0.4	-0.4	0.4	0.5
Bone: post-yield work	0.8	1.1	2.5	-1.6	-1.3	-0.4	0.9	-0.9	0.9	0.8
Bone: stiffness	0.2	0.3	0.5	0.2	-0.2	-0.7	-0.7	0.6	-0.6	-0.5
Bone: tissue strength	0.6	0.6	0.8	-0.8	0.6	0.9	0.8	-0.8	0.8	0.9
Bone: trabecular number	0.4	0.7	1.1	0.3	-1.1	-1.0	-0.7	0.8	-0.8	-0.8
Bone: trabecular spacing	0.4	0.5	1.2	0.1	1.1	1.0	0.4	-0.6	0.6	0.6
Bone: trabecular thickness	0.6	0.7	1.0	-1.0	0.6	0.6	0.8	-0.9	0.9	0.9
Bone: trabecular tissue density	3.3	4.7	5.6	-2.0	1.3	2.3	2.3	-2.3	2.3	2.4
Breakpoint value in progressive ratio session	1.8	2.0	4.3	2.1	-0.0	-1.1	-1.7	1.3	-1.4	-1.4
Distance traveled before self-admin	1.2	1.3	1.9	1.3	-0.3	-1.1	-1.4	1.1	-1.1	-1.3
Distance traveled after self-admin	0.1	0.1	0.1	0.4	0.2	-0.2	-0.4	0.1	-0.1	-0.2
Delta time in closed arm before/after self-admin	3.4	3.3	4.3	1.6	-1.8	-1.8	-1.8	1.8	-1.8	-2.1
Delta time in open arm before/after self-admin	0.9	0.9	2.1	1.5	-0.2	-1.0	-1.1	0.8	-0.9	-0.7
Diff in mean of infusions in LGA sessions	1.6	1.8	3.4	1.9	-0.1	-1.0	-1.5	1.4	-1.5	-1.4
Extinction: sum of active levers before priming	3.0	3.0	3.8	1.9	-1.0	-1.8	-1.9	1.7	-1.7	-1.8
Active lever presses in extinction session 6	1.4	1.4	2.7	1.6	0.1	-0.9	-1.5	1.0	-1.2	-1.1
Delta distance traveled before/after self-admin	0.6	0.6	0.9	-0.8	0.2	0.8	0.9	-0.8	0.8	1.0
Delta ambulatory time before/after self-admin	0.7	0.8	1.1	-0.9	0.4	1.0	1.0	-0.8	0.9	0.8
Time in closed arm before self-admin	0.2	0.2	0.3	-0.4	0.5	0.3	0.3	-0.5	0.5	0.5
Time in closed arm after self-admin	0.2	0.2	0.3	-0.6	-0.1	0.3	0.5	-0.5	0.5	0.2
Time in open arm before self-admin	0.4	0.4	1.0	-1.0	0.6	1.0	0.8	-0.4	0.3	0.3
Time in open arm after self-admin	0.1	0.2	0.7	0.4	0.8	0.4	-0.1	0.1	-0.3	0.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.3	1.1	0.3	-0.4	-0.9	0.4	-0.5	-0.5
Time to tail flick, vehicle, before self-admin	0.9	0.9	2.5	0.4	-1.6	-1.2	-0.6	0.8	-0.7	-0.6
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.7	0.6	-1.3	-1.1	-0.8	0.9	-0.8	-1.1
Time to tail flick, test, before self-admin	0.6	0.6	1.1	-0.2	-0.8	-0.8	-0.3	1.0	-0.9	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.8	-0.4	0.9	0.6	0.4	-0.1	0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	0.2	-0.1	-0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	1.2	0.6	1.1	0.7	0.0	-0.5	0.4	0.3
Ambulatory time before self-admin	0.8	0.9	1.6	1.3	0.2	-0.8	-1.2	0.9	-0.9	-0.9
Ambulatory time after self-admin	0.0	0.0	0.1	0.0	-0.2	-0.3	-0.2	-0.1	0.1	-0.0
Total heroin consumption	3.2	3.9	6.4	2.5	-0.1	-1.4	-2.3	2.1	-2.1	-2.1
Area under the delay curve	0.1	0.1	0.2	-0.5	-0.2	-0.5	-0.2	0.4	-0.4	-0.5
Delay disc. indifference point, 0s delay	0.3	0.3	1.4	-0.7	-1.2	-0.5	0.2	0.1	-0.1	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.0	-0.3	-0.5	-0.2	0.2	-0.1	-0.2
Delay disc. indifference point, 2s delay	0.3	0.3	1.2	-1.1	-0.4	-0.0	0.5	-0.3	0.3	0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	0.1	-0.2	-0.2	0.6	-0.5	-0.5
Delay disc. indifference point, 4s delay	0.7	0.8	1.3	-0.3	-0.5	-1.0	-0.6	1.1	-1.1	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.6	-0.8	0.5	0.1	0.4	-0.0	-0.0	-0.1
Delay discount exponential model param	0.1	0.1	0.3	0.5	0.1	0.5	0.1	-0.4	0.4	0.5
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	0.2	0.5	0.2	-0.4	0.4	0.5
Fecal boli incidents, locomotor time 1	0.4	0.5	0.9	0.2	0.5	0.4	0.5	-0.9	1.0	0.9
Change in fecal boli incidents, locomotor task	0.5	0.5	2.2	-1.5	-0.7	0.4	0.7	-0.2	0.2	0.2
Time >=10cm from walls, locomotor time 1	2.1	2.1	3.4	-1.2	-0.4	0.7	1.6	-1.8	1.8	1.8
Bouts of movement, locomotor time 1	0.7	0.8	2.5	1.6	1.5	0.0	-0.7	0.3	-0.2	-0.3
Total resting periods, locomotor time 1	0.6	0.7	2.6	1.3	1.6	-0.0	-0.6	0.2	-0.2	-0.3
Rest time, locomotor task time 1	1.3	1.4	2.3	-0.8	1.5	0.9	1.2	-1.3	1.3	1.2
Distance moved, locomotor task time 1	0.5	0.6	2.9	0.2	-1.7	-0.5	-0.5	0.4	-0.5	-0.5
Vertical activity count, locomotor time 1	0.6	0.6	1.1	-1.1	-0.4	0.9	0.8	-0.8	0.7	0.7
Time >=10cm from walls, locomotor time 2	0.5	0.6	1.0	-0.3	1.0	0.9	0.6	-0.7	0.7	0.9
Bouts of movement, locomotor time 2	2.0	2.1	6.4	2.5	-0.8	-1.4	-1.5	1.1	-1.1	-1.0
Total resting periods, locomotor time 2	1.4	1.5	5.3	2.3	-1.0	-1.3	-1.1	0.7	-0.8	-0.7
Rest time, locomotor task time 2	1.8	2.0	3.3	-0.9	0.4	1.0	1.7	-1.8	1.8	1.7
Distance moved, locomotor task time 2	0.2	0.2	0.4	0.3	0.2	0.1	-0.6	0.5	-0.6	-0.5
Vertical activity count, locomotor time 2	0.3	0.4	1.4	-0.4	1.2	1.0	0.1	0.1	-0.1	0.0
Weight adjusted by age	2.4	2.7	5.2	2.3	-1.7	-1.9	-1.6	1.2	-1.2	-1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.1	-0.6	-0.4	-0.0	0.1	-0.1	-0.1
Locomotion in novel chamber	2.3	2.8	3.8	-1.8	0.7	1.3	1.8	-1.9	1.9	1.9
Locomotion in novel chamber post-restriction	1.5	1.8	2.1	-1.0	1.2	1.5	1.4	-1.4	1.4	1.5
Progressive ratio	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.1	-0.3	0.3	0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	0.2	0.5	0.2	-0.1	0.1	0.2
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.1	-0.1	0.3	-0.1	0.4	-0.4	-0.2
Run reversals in cocaine runway, females	1.1	1.1	1.8	0.2	-1.3	-1.3	-0.7	1.2	-1.1	-1.1
Run reversals in cocaine runway, males	1.1	1.0	1.8	-1.3	1.3	1.1	0.9	-0.6	0.6	0.9
Latency to leave start box in cocaine runway	0.5	0.6	2.1	-1.4	-0.7	0.1	0.8	-0.5	0.5	0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.0	0.1	-0.1	-0.1
Latency to leave start box in cocaine runway, M	3.2	3.1	5.3	-2.3	0.4	1.5	2.0	-1.8	1.8	1.8
Cd content in liver	1.3	1.5	1.8	-1.1	1.1	1.4	1.2	-1.2	1.2	1.3
Co content in liver	2.1	2.5	4.6	-0.9	2.0	2.1	1.4	-1.5	1.5	1.5
Cu content in liver	0.3	0.4	0.7	0.4	-0.4	-0.5	-0.6	0.8	-0.8	-0.8
Fe content in liver	0.1	0.1	0.3	0.3	-0.6	-0.2	-0.1	0.1	-0.1	-0.0
K content in liver	0.8	0.8	1.6	0.3	-1.1	-1.3	-0.8	0.8	-0.8	-0.9
Mg content in liver	0.4	0.5	1.4	-0.0	-1.2	-1.0	-0.4	0.5	-0.5	-0.5
Mn content in liver	1.4	1.6	2.0	1.0	-0.5	-1.4	-1.4	1.4	-1.4	-1.3
Na content in liver	0.2	0.2	0.4	0.4	0.1	-0.4	-0.6	0.5	-0.5	-0.5
Rb content in liver	1.1	1.4	2.1	-1.5	-0.0	0.9	1.4	-1.3	1.3	1.3
Se content in liver	0.4	0.5	1.0	0.7	-0.9	-1.0	-0.6	0.4	-0.4	-0.5
Sr content in liver	6.1	5.6	7.9	2.8	-0.6	-2.1	-2.7	2.5	-2.5	-2.6
Zn content in liver	3.8	4.2	5.4	2.3	-0.9	-2.0	-2.3	2.1	-2.1	-2.2