Hub : Genes

Pc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000019372	0.26	0.12	2.9e-04	0.01	0.04	0.04	0.01	1.7e-02	4.4e-05	6.6e-05	1.6e-02
2	Brain	gene expression	ENSRNOG00000019372	0.06	0.05	1.4e-03	0.01	0.03	0.02	0.01	7.7e-02	1.8e-03	2.9e-03	2.4e-02
3	LHb	intron excision ratio	chr1:201799513:201879025	0.28	0.16	2.0e-03	0.1	0.13	0.09	0.1	2.8e-03	6.5e-04	3.6e-03	1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	2.9	9.3	16.1	0.7	-3.4	4.0
BMI without tail	0.9	1.9	3.5	0.3	-1.5	1.9
Body weight	1.6	6.9	9.9	3.1	-1.5	2.9
Epididymis fat weight	1.1	2.7	6.8	-2.6	-0.0	-1.1
Glucose	1.9	2.9	7.0	-2.6	-1.3	0.4
Heart weight	1.1	1.6	4.1	-2.0	0.0	-0.8
Left kidney weight	0.5	1.3	2.2	-0.9	1.0	-1.5
Right kidney weight	0.2	0.7	1.2	0.1	0.9	-1.1
Tail length	1.0	2.9	3.8	1.8	2.0	-1.3
Length with tail	1.3	4.6	12.6	3.6	1.0	0.4
Length without tail	1.3	2.9	6.9	2.6	-0.2	1.3
Liver weight, left	0.3	0.4	0.7	-0.5	0.7	-0.8
Liver weight, right	0.3	0.5	0.7	0.1	0.8	-0.9
Parametrial fat weight	1.3	2.5	7.1	-2.7	-0.5	-0.3
Retroperitoneal fat weight	2.2	7.4	18.2	-4.3	0.3	-2.0
Intraocular pressure	0.6	0.8	1.1	0.6	1.1	-1.0
Extensor digitorum longus weight	3.3	13.3	30.3	5.5	-0.6	3.0
Soleus weight	2.2	6.3	9.1	-2.6	1.7	-3.0
Tibialis anterior weight	5.2	17.8	48.8	7.0	0.9	2.0
Tibia length	0.6	1.8	5.1	2.3	0.4	0.3
Number of licking bursts	0.2	0.2	0.4	0.2	-0.5	0.6
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	0.2	-0.2
Times rat made contact with spout	0.4	0.5	0.8	0.1	-0.8	0.9
Mean time between licks in bursts	0.1	0.1	0.2	0.4	0.5	-0.2
Mean num. licks in bursts	0.1	0.1	0.2	-0.5	-0.0	-0.1
Std. dev. time between licks in bursts	1.6	1.9	3.2	0.4	1.8	-1.5
Water consumed over 24 hours	0.3	0.3	0.6	0.3	-0.5	0.8
Indifference point 0 sec	0.1	0.1	0.3	-0.3	-0.5	0.2
Indifference point AUC	2.3	2.7	7.1	2.7	-0.1	1.0
Indifference point function ln k	4.9	7.0	11.5	-3.4	1.4	-2.7
Indifference point function log k	4.9	7.0	11.5	-3.4	1.4	-2.7
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	0.1	0.1	-0.3
Delay discounting total patch changes 12 sec	3.0	3.9	7.8	2.8	-0.8	1.8
Delay discounting total patch changes 18 sec	0.7	0.9	1.1	1.1	-0.7	1.1
Delay discounting total patch changes 24 sec	1.2	1.5	4.2	2.1	0.2	0.5
Delay discounting total patch changes 6 sec	0.8	1.2	1.9	0.8	-1.0	1.4
Delay discounting time to switch 0 sec	3.2	4.9	8.2	0.5	-2.5	2.9
Delay discounting water rate 0 sec	4.0	6.3	10.9	-1.0	2.7	-3.3
Delay discounting water rate 12 sec	7.6	11.4	19.1	-2.0	3.4	-4.4
Delay discounting water rate 18 sec	2.7	3.5	5.0	-1.7	1.6	-2.2
Delay discounting water rate 24 sec	4.2	5.7	9.5	-1.2	2.5	-3.1
Delay discounting water rate 6 sec	4.1	5.9	9.8	-0.7	2.7	-3.1
Locomotor activity	2.3	3.6	5.3	-1.6	1.7	-2.3
Locomotor testing distance	3.0	5.0	7.2	-2.0	2.0	-2.7
Locomotor testing rearing	1.6	2.5	5.4	-2.3	0.6	-1.3
Light reinforcement 1	0.2	0.3	0.5	-0.2	0.5	-0.7
Light reinforcement 2	0.3	0.4	0.8	-0.9	0.1	-0.6
Reaction time number correct	0.7	1.0	2.0	1.4	0.9	-0.4
Reaction time mean minus median	1.6	2.1	3.6	1.0	-1.3	1.9
Reaction time mean minus median AUC	0.5	0.7	1.4	1.2	-0.2	0.8
Reaction time num false alarms	1.3	1.8	2.8	0.2	1.7	-1.6
Reaction time num false alarms AUC	0.8	1.1	1.8	0.7	1.3	-1.0
Reaction time trials correct on left	0.7	1.0	2.0	1.4	0.9	-0.4
Reaction time trials on left	0.8	1.1	2.4	1.5	1.0	-0.4
Reaction time mean	0.3	0.4	0.5	-0.7	-0.6	0.4
Reaction time mean AUC	0.4	0.5	0.8	-0.9	-0.8	0.5
Median of all reaction times	0.4	0.6	1.4	-1.2	-0.6	0.2
Reaction time omissions	0.6	0.9	1.9	1.4	-0.1	0.8
Reaction time false alarm rate	0.5	0.7	1.0	-0.1	1.0	-1.0
Reaction time premature initiation rate	0.4	0.5	1.2	1.1	0.4	0.3
Reaction time premature initiations	1.3	1.8	4.6	2.1	0.9	0.1
Std. dev. reaction times	0.5	0.6	1.1	0.2	-0.9	1.1
Reaction time trials completed	0.8	1.1	2.4	1.5	1.0	-0.4
Reaction time trials AUC	0.6	0.9	1.6	1.3	0.9	-0.4
Social response proportion	1.2	1.3	2.1	0.4	-1.2	1.5
Social responses	0.3	0.3	0.9	1.0	0.1	0.3
Social time	0.1	0.2	0.5	0.7	0.1	0.2
Conditioned locomotion	2.1	2.5	6.5	2.6	1.1	-0.1
Cocaine response after cond. corrected	0.6	0.6	0.8	-0.9	0.6	-0.9
Cocaine response after cond. not corrected	0.5	0.6	1.5	-1.2	0.1	-0.5
Cocaine response before conditioning	0.6	0.8	1.3	0.1	-1.0	1.1
Saline control response	1.3	1.7	2.4	1.6	-0.7	1.5
Condit. Reinf. active minus inactive responses	1.4	1.8	2.4	-1.5	-1.5	0.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.4	-1.5	-1.0	0.4
Condit. Reinf. active responses	1.9	2.6	3.9	-1.1	-2.0	1.6
Condit. Reinf. inactive responses	1.2	1.4	2.4	0.0	-1.4	1.6
Condit. Reinf. lever presses	2.0	2.8	4.6	0.9	-1.7	2.2
Condit. Reinf. lever reinforcers received	1.9	2.7	4.0	-0.8	-2.0	1.8
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.7	0.8	-1.0
Pavlov. Cond. magazine entry latency	3.1	3.5	5.8	1.2	-1.8	2.4
Pavlov. Cond. change in total contacts	2.6	3.6	5.7	0.9	-2.1	2.4
Pavlov. Cond. index score	2.2	2.8	4.5	1.2	-1.6	2.1
Pavlov. Cond. latency score	1.8	2.3	3.6	1.1	-1.5	1.9
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.9	-0.3	0.6
Pavlov. Cond. magazine entry number	4.5	5.6	9.1	-1.6	2.2	-3.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.1	-1.0	0.6	-1.1
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.2	5.1	1.3	-1.7	2.2
Pavlov. Cond. response bias	1.3	1.8	2.8	1.0	-1.2	1.7
Conditioned reinforcement - actives	0.1	0.1	0.3	0.1	0.4	-0.5
Conditioned reinforcement - inactives	2.8	3.1	7.7	-2.8	0.2	-1.3
Conditioned locomotion	4.7	5.6	7.7	-2.6	1.6	-2.8
Intermittent access intake day 1-15 change	0.5	0.5	0.9	-0.1	0.7	-0.9
Intermittent access intake escalation	0.2	0.2	0.4	-0.4	0.3	-0.6
Intermittent access intake escalation 2	0.4	0.4	0.8	-0.1	0.7	-0.9
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.5	-1.6	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.8	0.8	2.2	-1.5	-0.5	-0.2
Intermitt. access escalation Index	1.1	1.0	1.9	-1.4	0.4	-1.0
Intermittent access day 1 total infusions	6.0	6.8	16.1	-4.0	-1.9	0.6
Intermittent access day 15 total infusions	4.1	4.6	12.8	-3.6	-0.7	-0.7
Intermittent access terminal intake (last 3 days)	3.5	3.8	10.3	-3.2	-1.1	-0.1
Intermittent access total infusions	3.5	3.8	8.9	-3.0	-1.5	0.5
Intermittent access day 1 locomotion	4.4	4.5	9.2	-3.0	-1.8	1.0
Intermittent access day 15 total locomotion	2.4	2.5	7.0	-2.7	-0.7	-0.2
Intermittent access total locomotion	5.3	6.0	14.4	-3.8	-1.8	0.6
Intermittent access standard deviation	0.4	0.5	0.6	-0.8	0.4	-0.8
Cocaine induced anxiety	0.0	0.0	0.0	0.1	0.1	-0.1
Post-drug Anxiety	1.0	1.1	3.1	1.8	0.3	0.3
Baseline Anxiety	1.3	1.4	3.9	2.0	0.3	0.4
Lifetime Intake	3.2	3.6	8.3	-2.9	-1.5	0.5
Incentive Sensitization - Responses	0.4	0.4	0.5	-0.6	-0.7	0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	-0.8	-0.6	0.3
Progressive ratio test 1 active lever presses	1.0	1.1	3.0	-1.7	-0.2	-0.4
Progressive ratio test 1 breakpoint	0.8	0.9	2.4	-1.5	-0.0	-0.5
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.6	-1.3	-0.3	-0.1
Progressive ratio test 2 active lever presses	1.6	1.8	4.9	-2.2	-0.5	-0.3
Progressive ratio test 2 breakpoint	1.8	2.0	5.1	-2.2	0.1	-1.0
Progressive ratio test 2 inactive lever presses	4.5	5.2	14.5	-3.8	-0.7	-0.7
Total sessions with >9 infusions	0.8	0.9	2.3	-1.5	-0.6	0.1
Short access day 1 total inactive lever presses	2.3	2.5	6.8	-2.6	-0.1	-0.9
Short access day 10 total inactive lever presses	1.6	1.8	3.8	-1.9	0.4	-1.2
Short access day 1 total infusions	2.6	2.7	6.6	-2.6	-1.2	0.3
Short access day 10 total infusions	4.7	5.1	6.3	-2.5	-2.5	1.8
Short access total infusions	2.1	2.3	4.4	-2.1	-1.4	0.8
Short access day 1 locomotion	1.9	2.0	3.4	-1.8	-1.4	0.8
Short access day 10 total locomotion	1.6	1.7	2.6	-1.6	-1.4	0.9
Short access total locomotion	1.7	1.7	2.6	-1.6	-1.4	0.9
Compulsive drug intake	1.9	1.9	4.8	2.2	0.9	-0.1
One hour access (0.3 mA shock)	4.4	5.1	13.6	-3.7	-0.2	-1.3
One hour access (shock baseline)	3.5	4.1	11.3	-3.4	-0.5	-0.8
Number of responses in last shaping day	0.7	0.7	1.0	-0.9	0.6	-1.0
Context. condit. distance diff. score	1.2	1.4	3.1	-1.8	0.4	-1.0
Locomotion velocity, session 1	0.4	0.5	0.6	-0.6	0.6	-0.8
Locomotion distance, session 1	1.2	1.5	2.1	-0.6	-1.4	1.4
Locomotion velocity, session 2	1.2	1.5	2.3	1.5	-0.6	1.3
Locomotion distance, session 2	0.6	0.9	1.6	0.4	-1.0	1.3
Locomotion velocity, session 3	0.8	1.0	1.9	-1.4	-0.9	0.5
Locomotion distance, session 3	0.1	0.1	0.3	-0.6	-0.1	-0.0
Stereotopy head waving bouts, day 3	1.0	1.2	3.3	-1.8	-0.5	-0.1
Stereotopy head waving duration, day 3	0.8	1.0	2.7	-1.6	-0.5	-0.1
Locomotion velocity, session 7	0.7	0.8	1.2	-1.1	-0.9	0.6
Locomotion distance, session 7	0.0	0.0	0.0	-0.0	-0.1	0.1
Stereotopy head waving bouts, day 7	1.1	1.3	1.7	-1.2	-1.3	0.9
Stereotopy head waving duration, day 7	2.2	2.7	4.4	-0.0	-1.9	2.1
Locomotion velocity, session 8	0.2	0.2	0.5	0.7	0.3	0.1
Locomotion distance, session 8	0.3	0.4	1.1	-1.1	-0.3	-0.0
Degree of sensitization distance	0.1	0.1	0.2	0.0	-0.4	0.5
Degree of sensitization stereotypy	1.2	1.3	2.1	0.1	-1.3	1.5
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.2	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.4	-0.8	0.6
Condit. Reinf. active responses	0.2	0.3	0.4	0.1	-0.7	0.6
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.2	0.2
Incentive salience index mean	0.6	0.7	1.1	0.1	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.4	0.7	0.8	-0.4	0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.6	-0.6	-0.8	0.4
Time in novel zone, hab. session 1	0.9	0.8	1.3	-0.4	1.1	-1.1
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.5	-0.6	0.9
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.9	-0.2	-0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	-0.2	0.1
Time in familiar zone, hab. session 2	0.9	0.9	1.4	0.8	1.2	-0.9
Time in novel zone, hab. session 2	1.2	1.3	1.8	-0.8	-1.4	1.1
Total zone transitions, hab. session 2	3.6	4.7	7.3	-0.4	-2.6	2.7
Total locomotion distance, hab. session 2	1.0	1.4	1.9	-0.9	-1.4	1.1
Locomotion velocity, hab. session 2	1.1	1.4	2.0	-1.1	-1.4	1.1
Novel to familiar place preference ratio	1.5	1.6	2.5	0.4	-1.4	1.6
Novelty place preference	1.2	1.2	1.9	0.0	-1.4	1.4
Time in novel zone, NPP test	1.0	1.0	1.6	-0.1	-1.2	1.2
Total zone transitions, NPP test	1.2	1.7	3.0	0.4	-1.4	1.7
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.6	-0.6	0.4
Locomotion velocity, NPP test	0.2	0.2	0.3	-0.4	-0.5	0.4
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.4	0.4	-0.6
Pavlov. Cond. magazine entry latency	1.2	1.6	2.4	-0.6	-1.6	1.4
Pavlov. Cond. change in total contacts	0.8	0.8	1.3	-0.4	-1.2	1.0
Pavlov. Cond. index score	0.1	0.2	0.2	0.2	-0.4	0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.1	-0.5	0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	-0.1	0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.2	-0.5	0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.2	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.3	-0.6	0.7
Pavlov. Cond. response bias	0.1	0.1	0.1	0.2	-0.4	0.4
Bone: apparent density	2.8	4.7	6.9	-0.7	-2.6	2.5
Bone surface	4.6	8.1	13.8	0.9	-3.1	3.7
Bone volume	3.3	5.6	8.9	0.0	-2.8	3.0
Bone: connectivity density	3.8	5.9	10.0	0.3	-2.8	3.2
Bone: cortical apparent density	0.2	0.3	0.6	0.8	0.4	-0.1
Bone: cortical area	0.5	0.7	2.1	1.4	0.4	0.2
Bone: cortical porosity	0.4	0.4	0.6	0.0	-0.8	0.8
Bone: cortical porosity	0.4	0.5	0.7	0.5	-0.6	0.9
Bone: cortical thickness	2.7	4.4	10.7	3.3	1.6	-0.2
Bone: cortical thickness	1.2	1.5	2.1	1.3	1.5	-0.8
Bone: cortical tissue density	0.3	0.3	0.7	0.9	0.5	-0.1
Bone: elastic displacement	3.0	3.4	5.2	0.5	2.3	-2.2
Bone: elastic work	1.5	2.0	2.7	1.7	1.6	-0.9
Bone: endosteal estimation	1.1	2.4	4.9	-2.2	-1.5	0.5
Bone: endosteal perimeter	2.3	4.7	7.8	-2.8	-2.3	1.0
Bone: final force	0.9	1.5	2.0	1.4	-0.7	1.4
Bone: final moment	0.8	1.3	1.8	1.3	-0.7	1.3
Bone: marrow area	1.1	2.4	5.0	-2.2	-1.4	0.5
Bone: maximum diameter	0.1	0.1	0.1	0.3	-0.3	0.3
Bone: maximum force	2.5	4.4	7.6	0.8	-2.3	2.8
Bone: maximum moment	2.2	3.8	6.4	0.7	-2.1	2.5
Bone: minimum diameter	1.6	3.0	4.0	-2.0	-1.9	1.1
Bone: periosteal estimation	0.1	0.2	0.3	-0.3	-0.6	0.4
Bone: periosteal perimeter	0.5	0.8	1.4	-0.3	-1.2	1.0
Bone: post-yield work	9.2	12.5	19.8	-1.6	-4.5	3.9
Bone: stiffness	2.8	4.5	7.5	0.5	-2.4	2.7
Bone: tissue strength	0.4	0.4	0.7	-0.2	-0.8	0.7
Bone: trabecular number	2.9	4.5	6.9	-0.3	-2.6	2.6
Bone: trabecular spacing	0.7	0.9	1.4	0.0	1.2	-1.2
Bone: trabecular thickness	1.6	1.9	2.4	-1.5	-1.6	1.0
Bone: trabecular tissue density	1.9	2.6	4.4	-1.4	1.2	-2.1
Breakpoint value in progressive ratio session	1.8	2.0	3.5	1.9	-0.6	1.4
Distance traveled before self-admin	0.1	0.2	0.3	0.3	-0.4	0.5
Distance traveled after self-admin	0.1	0.2	0.2	0.4	-0.4	0.4
Delta time in closed arm before/after self-admin	0.7	0.7	0.9	0.9	1.0	-0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.2	-0.3	0.2
Diff in mean of infusions in LGA sessions	0.5	0.6	1.6	1.3	0.3	0.2
Extinction: sum of active levers before priming	3.3	3.3	4.3	2.1	-1.2	2.1
Active lever presses in extinction session 6	2.3	2.2	6.3	2.5	0.4	0.3
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Time in closed arm before self-admin	0.3	0.3	0.6	-0.4	-0.7	0.5
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	0.1	0.0
Time in open arm before self-admin	0.6	0.6	1.0	-0.2	1.0	-0.9
Time in open arm after self-admin	0.3	0.4	0.6	-0.2	0.7	-0.8
Sum of active levers in priming session hrs 5-6	2.3	2.2	6.0	2.4	0.9	-0.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.1	-0.3	-1.1	1.0
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.4	1.1	-0.6	1.2
Time to tail flick, test, before self-admin	1.6	1.6	3.6	-1.9	-0.9	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	1.0	-0.4	0.8
Delta time to tail flick, test, before/after SA	3.2	2.9	6.5	2.5	1.3	-0.6
Ambulatory time before self-admin	0.4	0.5	0.8	0.2	-0.7	0.9
Ambulatory time after self-admin	0.9	1.0	1.7	-0.8	-1.3	0.9
Total heroin consumption	2.5	3.0	6.5	2.6	-0.5	1.5
Area under the delay curve	1.1	1.1	2.4	-1.5	-0.8	0.5
Delay disc. indifference point, 0s delay	2.0	2.2	6.5	-2.5	-0.4	-0.2
Delay disc. indifference point, 16s delay	0.7	0.7	1.1	-1.0	-0.9	0.4
Delay disc. indifference point, 2s delay	0.8	0.9	2.4	-1.6	-0.4	0.0
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.0	0.7	-0.7
Delay disc. indifference point, 4s delay	0.5	0.5	1.5	-1.2	-0.2	-0.0
Delay disc. indifference point, 8s delay	0.6	0.6	1.6	-1.3	-0.3	0.1
Delay discount exponential model param	0.8	0.8	1.9	1.4	0.7	-0.4
Delay discount hyperbolic model param	0.8	0.8	1.9	1.4	0.6	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	0.8	-0.4	0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.6	-0.2	0.1
Time >=10cm from walls, locomotor time 1	3.4	3.4	4.5	-1.9	-2.1	1.4
Bouts of movement, locomotor time 1	1.6	1.7	4.3	2.1	-0.2	0.9
Total resting periods, locomotor time 1	1.5	1.6	3.8	1.9	-0.4	1.0
Rest time, locomotor task time 1	0.9	1.0	1.6	-0.8	0.9	-1.3
Distance moved, locomotor task time 1	0.7	0.8	1.2	-0.3	-1.1	1.0
Vertical activity count, locomotor time 1	0.8	0.8	1.8	-1.4	0.2	-0.7
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.1	-0.3	0.3
Bouts of movement, locomotor time 2	0.5	0.5	0.9	0.9	-0.3	0.8
Total resting periods, locomotor time 2	0.3	0.4	0.6	0.6	-0.5	0.7
Rest time, locomotor task time 2	1.8	2.1	5.1	-2.2	0.1	-1.0
Distance moved, locomotor task time 2	0.7	0.9	2.3	1.5	0.1	0.5
Vertical activity count, locomotor time 2	1.9	2.1	3.1	1.1	1.8	-1.4
Weight adjusted by age	1.3	1.5	3.7	1.9	-0.2	0.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	0.9	-0.9	-1.0	0.8
Locomotion in novel chamber	3.6	4.4	11.2	-3.4	0.1	-1.4
Locomotion in novel chamber post-restriction	1.8	2.1	4.3	-2.1	0.5	-1.3
Progressive ratio	3.2	3.8	6.2	-0.1	-2.2	2.5
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	0.3	-0.1
Seeking ratio, punishment vs. effort	2.9	3.5	5.9	-0.2	2.2	-2.4
Run reversals in cocaine runway, females	0.8	0.8	1.2	-0.2	-1.0	1.1
Run reversals in cocaine runway, males	2.3	2.3	3.6	0.3	1.9	-1.8
Latency to leave start box in cocaine runway	1.1	1.2	1.7	-0.9	-1.3	1.0
Latency to leave start box in cocaine runway, F	0.6	0.7	0.8	-0.9	-0.9	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.1	-0.4	0.3
Cd content in liver	0.8	0.8	1.3	-0.9	0.7	-1.1
Co content in liver	2.8	3.3	5.4	-0.3	2.1	-2.3
Cu content in liver	0.2	0.3	0.4	0.6	-0.3	0.6
Fe content in liver	0.0	0.0	0.0	0.2	0.2	-0.0
K content in liver	2.3	2.3	3.8	0.5	-1.6	2.0
Mg content in liver	3.5	3.6	5.6	-0.9	-2.4	2.1
Mn content in liver	2.0	2.3	3.1	1.7	-1.0	1.8
Na content in liver	0.3	0.3	0.9	1.0	0.4	-0.0
Rb content in liver	1.8	2.2	5.2	-2.3	-1.1	0.2
Se content in liver	1.2	1.4	2.0	-0.7	-1.4	1.3
Sr content in liver	1.7	1.6	4.4	2.1	0.6	0.3
Zn content in liver	0.9	1.0	1.7	1.3	-0.5	1.0