Hub : Traits

Pavlov. Cond. change in total contacts

Pavlovian Conditioned Approach, Change in total contacts across 5 days of testing

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

1 locus · 1 gene with independent associations · 20 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	154320012	157330368	20	1	2.8e-08	1.52e-07	2.08e-02	Folr2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Tail length	4.71	8	0	0	0.99	6.48e-08	Art2b Folr2 LOC120097346 LOC120097348 LOC120099897 P2ry6 Pgap2 Rhog
Length with tail	2.81	3	0	0	0	1.00e+00	Art2b LOC120097346 P2ry6
Retroperitoneal fat weight	3.77	2	0	0	0	1.00e+00	Numa1 Relt
Mean time between licks in bursts	7.71	2	0	0	0	1.00e+00	LOC120097348 Plekhb1
Condit. Reinf. active minus inactive responses	10	12	0	0	1	1.55e-21	Arap1 Art2b Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Condit. Reinf. active responses	10.88	13	0	0	0.99	5.69e-26	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Condit. Reinf. inactive responses	9.97	4	0	0	1	7.05e-05	Art2b LOC120097346 P2ry6 Plekhb1
Condit. Reinf. lever presses	19.73	13	9	900	1	4.68e-34	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Condit. Reinf. lever reinforcers received	12.08	13	0	0	0.99	2.52e-26	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. lever latency	22.38	13	13	1300	-1	1.01e-43	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. index score	17.68	13	0	0	1	1.09e-49	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. latency score	16.22	13	0	0	1	1.19e-44	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. lever contacts	22.75	13	13	1300	1	3.25e-41	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. magazine entry number	10.99	10	0	0	-1	3.45e-30	Arap1 Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 Pgap2 Relt Rhog
Pavlov. Cond. lever-magazine prob. diff.	16.86	13	0	0	1	9.44e-48	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Pavlov. Cond. response bias	23.78	13	13	1300	1	1.48e-50	Arap1 Art2b Clpb Folr2 LOC120097346 LOC120097348 LOC120099897 Numa1 P2ry6 Pgap2 Plekhb1 Relt Rhog
Degree of sensitization stereotypy	9.92	5	0	0	1	9.75e-10	Arap1 Clpb Folr2 LOC120099897 Relt
Time in open arm before self-admin	10.3	1	0	0	0	1.00e+00	Relt

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.38
Adipose	alternative TSS	1	0	1.42
Adipose	gene expression	1	0	1.39
Adipose	isoform ratio	0	0	1.37
Adipose	intron excision ratio	0	0	1.2
Adipose	mRNA stability	1	0	1.43
BLA	alternative polyA	0	0	1.49
BLA	alternative TSS	0	0	1.4
BLA	gene expression	0	0	1.39
BLA	isoform ratio	0	0	1.47
BLA	intron excision ratio	0	0	1.34
BLA	mRNA stability	0	0	1.42
Brain	alternative polyA	0	0	1.38
Brain	alternative TSS	2	0	1.38
Brain	gene expression	2	0	1.37
Brain	isoform ratio	0	0	1.38
Brain	intron excision ratio	0	0	1.34
Brain	mRNA stability	1	0	1.35
Eye	alternative polyA	0	0	1.47
Eye	alternative TSS	0	0	1.45
Eye	gene expression	0	0	1.45
Eye	isoform ratio	0	0	1.28
Eye	intron excision ratio	0	0	1.37
Eye	mRNA stability	0	0	1.51
IL	alternative polyA	0	0	1.41
IL	alternative TSS	0	0	1.26
IL	gene expression	0	0	1.34
IL	isoform ratio	0	0	1.43
IL	intron excision ratio	0	0	1.31
IL	mRNA stability	0	0	1.37
LHb	alternative polyA	0	0	1.6
LHb	alternative TSS	0	0	1.5
LHb	gene expression	1	0	1.38
LHb	isoform ratio	0	0	1.45
LHb	intron excision ratio	0	0	1.38
LHb	mRNA stability	0	0	1.36
Liver	alternative polyA	0	0	1.34
Liver	alternative TSS	0	0	1.36
Liver	gene expression	5	0.1	1.44
Liver	isoform ratio	0	0	1.36
Liver	intron excision ratio	2	0	1.39
Liver	mRNA stability	1	0	1.41
NAcc	alternative polyA	0	0	1.46
NAcc	alternative TSS	2	0.1	1.33
NAcc	gene expression	2	0	1.37
NAcc	isoform ratio	1	0	1.38
NAcc	intron excision ratio	0	0	1.3
NAcc	mRNA stability	1	0	1.37
OFC	alternative polyA	0	0	1.49
OFC	alternative TSS	0	0	1.31
OFC	gene expression	0	0	1.36
OFC	isoform ratio	0	0	1.41
OFC	intron excision ratio	0	0	1.32
OFC	mRNA stability	0	0	1.39
PL	alternative polyA	0	0	1.52
PL	alternative TSS	0	0	1.38
PL	gene expression	2	0	1.38
PL	isoform ratio	0	0	1.38
PL	intron excision ratio	2	0	1.36
PL	mRNA stability	1	0	1.37
pVTA	alternative polyA	0	0	1.46
pVTA	alternative TSS	0	0	1.38
pVTA	gene expression	1	0	1.37
pVTA	isoform ratio	0	0	1.35
pVTA	intron excision ratio	0	0	1.31
pVTA	mRNA stability	0	0	1.4
RMTg	alternative polyA	0	0	1.21
RMTg	alternative TSS	0	0	1.26
RMTg	gene expression	0	0	1.35
RMTg	isoform ratio	0	0	1.23
RMTg	intron excision ratio	0	0	1.35
RMTg	mRNA stability	0	0	1.36