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chr10:58,773,413-61,500,745

Best TWAS P=2.718662e-08 · Best GWAS P=2.345894e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Sgsm2	gene expression	ENSRNOG00000027194	0.12	0.08	enet	37	0.11	7.4e-12	-4.2	-5.4	6.0e-08	-0.77	0.34	0.66	FALSE
2	Adipose	NA	gene expression	ENSRNOG00000064121	0.14	0.03	top1	1	0.03	5.4e-04	5.5	5.5	3.9e-08	0.84	0.06	0.14	FALSE
3	Adipose	Scarf1	isoform ratio	ENSRNOT00000088722	0.04	0.03	top1	1	0.03	3.2e-04	5.5	5.5	4.3e-08	0.95	0.05	0.10	FALSE
4	Adipose	Scarf1	isoform ratio	ENSRNOT00000104013	0.04	0.02	top1	1	0.02	1.1e-03	5.5	-5.5	4.3e-08	-0.96	0.05	0.10	FALSE
5	Adipose	Myo1c	intron excision ratio	chr10:60499487:60505081	0.07	0.03	top1	1	0.03	7.3e-04	5.5	5.5	3.9e-08	0.91	0.06	0.19	FALSE
6	Adipose	Sgsm2	mRNA stability	ENSRNOG00000027194	0.03	0.01	blup	820	0.01	1.6e-02	5.5	-5.3	1.5e-07	-0.96	0.19	0.62	FALSE
7	BLA	Rtn4rl1	gene expression	ENSRNOG00000003121	0.17	0.12	top1	1	0.12	4.0e-07	5.3	5.3	9.6e-08	0.98	0.29	0.48	FALSE
8	BLA	Inpp5k	gene expression	ENSRNOG00000056954	0.25	0.22	top1	1	0.22	3.5e-12	5.5	5.5	4.1e-08	0.94	0.20	0.80	FALSE
9	BLA	Smyd4	intron excision ratio	chr10:60200371:60201453	0.08	0.07	top1	1	0.07	1.7e-04	5.5	-5.5	3.9e-08	-0.98	0.06	0.16	FALSE
10	Brain	Rtn4rl1	gene expression	ENSRNOG00000003121	0.20	0.15	blup	755	0.15	3.4e-14	5.5	5.3	9.2e-08	0.97	0.22	0.78	FALSE
11	Brain	Crk	gene expression	ENSRNOG00000025792	0.33	0.23	lasso	30	0.23	4.9e-21	5.5	5.6	2.7e-08	0.99	0.17	0.83	TRUE
12	Brain	Doc2b	gene expression	ENSRNOG00000060054	0.80	0.51	enet	93	0.52	5.6e-56	5.6	5.2	1.7e-07	0.98	0.15	0.85	FALSE
13	Brain	Doc2b	intron excision ratio	chr10:60633027:60636786	0.25	0.08	blup	1275	0.09	2.0e-08	5.5	-5.2	2.4e-07	-0.97	0.18	0.82	FALSE
14	Brain	Myo1c	mRNA stability	ENSRNOG00000004072	0.06	0.04	top1	1	0.04	1.6e-04	5.5	-5.5	3.6e-08	-0.96	0.07	0.23	FALSE
15	IL	Rap1gap2	gene expression	ENSRNOG00000002652	0.85	0.41	top1	1	0.41	7.1e-11	5.3	5.3	1.1e-07	0.96	0.11	0.87	FALSE
16	LHb	Crk	gene expression	ENSRNOG00000025792	0.25	0.17	top1	1	0.17	8.3e-05	5.5	5.5	3.6e-08	0.88	0.07	0.09	FALSE
17	Liver	Rpa1	gene expression	ENSRNOG00000003123	0.13	0.09	blup	812	0.10	1.1e-10	4.9	5.5	3.3e-08	0.99	0.22	0.78	FALSE
18	Liver	Crk	gene expression	ENSRNOG00000025792	0.05	0.03	top1	1	0.03	7.4e-04	5.5	5.5	3.9e-08	0.87	0.05	0.11	FALSE
19	Liver	Slc43a2	intron excision ratio	chr10:60411108:60413539	0.03	0.02	top1	1	0.02	6.0e-03	5.5	-5.5	3.4e-08	-0.93	0.03	0.05	FALSE
20	Liver	Serpinf1	mRNA stability	ENSRNOG00000003172	0.04	0.02	top1	1	0.02	2.2e-03	5.5	-5.5	4.6e-08	-0.98	0.04	0.06	FALSE
21	NAcc	Crk	gene expression	ENSRNOG00000025792	0.33	0.19	enet	8	0.27	1.2e-06	-4.5	5.2	2.0e-07	0.98	0.19	0.79	FALSE
22	NAcc	Doc2b	gene expression	ENSRNOG00000060054	0.71	0.52	lasso	3	0.53	4.8e-14	5.5	5.4	6.8e-08	0.98	0.16	0.84	FALSE
23	NAcc	Ccdc92b	mRNA stability	ENSRNOG00000069756	0.23	0.15	top1	1	0.15	2.8e-04	5.5	5.5	3.9e-08	0.94	0.06	0.28	FALSE
24	NAcc2	Doc2b	gene expression	ENSRNOG00000060054	0.45	0.31	lasso	12	0.32	1.4e-17	5.5	5.5	3.5e-08	0.99	0.15	0.85	FALSE
25	NAcc2	NA	gene expression	ENSRNOG00000068527	0.12	0.05	top1	1	0.05	7.5e-04	5.3	-5.3	9.5e-08	-0.97	0.04	0.06	FALSE
26	OFC	Crk	gene expression	ENSRNOG00000025792	0.24	0.19	top1	1	0.19	2.2e-05	5.5	5.5	4.6e-08	0.89	0.07	0.10	FALSE
27	OFC	Doc2b	gene expression	ENSRNOG00000060054	0.46	0.10	enet	5	0.10	2.0e-03	5.5	5.3	1.3e-07	0.97	0.17	0.56	FALSE
28	OFC	Rph3al	gene expression	ENSRNOG00000061429	0.40	0.28	top1	1	0.28	2.7e-07	5.5	5.5	3.6e-08	0.62	0.09	0.66	FALSE
29	OFC	NA	gene expression	ENSRNOG00000068527	0.19	0.16	top1	1	0.16	1.1e-04	5.5	-5.5	3.9e-08	-0.96	0.05	0.15	FALSE
30	OFC	Rph3al	mRNA stability	ENSRNOG00000061429	0.27	0.18	top1	1	0.18	5.4e-05	5.5	5.5	3.6e-08	0.80	0.07	0.16	FALSE
31	PL	Rap1gap2	gene expression	ENSRNOG00000002652	0.75	0.33	top1	1	0.33	1.3e-08	5.2	5.2	2.0e-07	0.96	0.18	0.75	FALSE
32	PL	Crk	gene expression	ENSRNOG00000025792	0.28	0.14	enet	11	0.14	3.2e-04	5.5	5.4	7.2e-08	0.96	0.20	0.74	FALSE
33	PL	Doc2b	gene expression	ENSRNOG00000060054	0.23	0.03	enet	6	0.08	7.3e-03	5.5	5.2	1.7e-07	0.95	0.17	0.63	FALSE
34	PL2	Rtn4rl1	gene expression	ENSRNOG00000003121	0.12	0.11	top1	1	0.11	1.2e-06	5.5	5.5	4.0e-08	0.98	0.17	0.67	FALSE
35	PL2	Crk	gene expression	ENSRNOG00000025792	0.13	0.10	top1	1	0.10	5.6e-06	5.5	5.5	3.9e-08	0.87	0.13	0.51	FALSE
36	PL2	Doc2b	gene expression	ENSRNOG00000060054	0.21	0.12	top1	1	0.12	7.3e-07	5.5	5.5	4.0e-08	0.89	0.16	0.83	FALSE
37	PL2	NA	gene expression	ENSRNOG00000068527	0.10	0.05	enet	54	0.05	7.8e-04	5.4	-5.3	9.6e-08	-0.96	0.19	0.80	FALSE
38	PL2	Ccdc92b	gene expression	ENSRNOG00000069756	0.08	0.07	top1	1	0.07	8.1e-05	5.5	-5.5	4.6e-08	-0.89	0.05	0.46	FALSE
39	PL2	Smyd4	intron excision ratio	chr10:60200371:60201453	0.08	0.06	top1	1	0.06	3.9e-04	5.4	-5.4	6.9e-08	-0.98	0.05	0.08	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.