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Intermitt. access day 1 inactive lever presses

Intermittent access day 1 total inactive lever presses

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	33211184	34601262	1	1	1.55e-07	4.12e-01	4.39e-07	Ddx25
2	chr9	75969545	77365260	1	1	2.04e-41	1.67e-01	1.00e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	5.02	2	1	50	0	1e+00	Ddx25 Zfand2b
BMI without tail	28.87	2	1	50	0	1e+00	Ddx25 Zfand2b
Epididymis fat weight	111.28	1	1	50	0	1e+00	Zfand2b
Heart weight	71.7	1	1	50	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	50	0	1e+00	Zfand2b
Right kidney weight	28.13	2	1	50	0	1e+00	Ddx25 Zfand2b
Tail length	65.84	2	1	50	0	1e+00	Ddx25 Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	41.28	2	1	50	0	1e+00	Ddx25 Zfand2b
Liver weight, right	17.57	1	1	50	0	1e+00	Zfand2b
Parametrial fat weight	6.39	2	0	0	0	1e+00	Ddx25 Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1e+00	Zfand2b
Intraocular pressure	51.69	1	1	50	0	1e+00	Zfand2b
Tibialis anterior weight	1.65	1	0	0	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	50	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	50	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	50	0	1e+00	Zfand2b
Indifference point function ln k	54.42	1	1	50	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 12 sec	4.29	1	0	0	0	1e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	50	0	1e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	50	0	1e+00	Zfand2b
Locomotor activity	8.43	2	0	0	0	1e+00	Ddx25 Zfand2b
Locomotor testing distance	25.97	2	1	50	0	1e+00	Ddx25 Zfand2b
Locomotor testing rearing	51.42	2	1	50	0	1e+00	Ddx25 Zfand2b
Light reinforcement 1	19.25	1	1	50	0	1e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	50	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	50	0	1e+00	Zfand2b
Reaction time mean minus median AUC	118.19	2	1	50	0	1e+00	Ddx25 Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	50	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	50	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	50	0	1e+00	Zfand2b
Reaction time mean	20.45	2	1	50	0	1e+00	Ddx25 Zfand2b
Reaction time mean AUC	33.75	1	1	50	0	1e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1e+00	Zfand2b
Reaction time omissions	46.56	1	1	50	0	1e+00	Zfand2b
Reaction time false alarm rate	3.92	1	0	0	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	50	0	1e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	50	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	50	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	50	0	1e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	50	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	75.29	2	1	50	0	1e+00	Ddx25 Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	117.88	2	2	100	0	1e+00	Ddx25 Zfand2b
Intermittent access intake escalation	79.34	2	2	100	0	1e+00	Ddx25 Zfand2b
Intermittent access intake escalation 2	33.1	1	1	50	0	1e+00	Ddx25
Intermitt. access day 15 inactive lever presses	167.57	2	2	100	0	1e+00	Ddx25 Zfand2b
Intermitt. access escalation Index	14.59	1	0	0	0	1e+00	Ddx25
Intermittent access day 1 total infusions	71.42	1	1	50	0	1e+00	Zfand2b
Intermittent access day 15 total infusions	39.7	2	2	100	0	1e+00	Ddx25 Zfand2b
Intermittent access terminal intake (last 3 days)	34.89	2	2	100	0	1e+00	Ddx25 Zfand2b
Intermittent access total infusions	25.36	1	1	50	0	1e+00	Ddx25
Intermittent access day 1 locomotion	26.47	1	1	50	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	50	0	1e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Intermittent access standard deviation	229.02	2	1	50	0	1e+00	Ddx25 Zfand2b
Cocaine induced anxiety	69.01	2	1	50	0	1e+00	Ddx25 Zfand2b
Baseline Anxiety	199.76	2	1	50	0	1e+00	Ddx25 Zfand2b
Lifetime Intake	42.99	1	1	50	0	1e+00	Ddx25
Incentive Sensitization - Responses	164.28	2	1	50	0	1e+00	Ddx25 Zfand2b
Incentive Sensitization - Breakpoint	160.89	2	1	50	0	1e+00	Ddx25 Zfand2b
Progressive ratio test 1 active lever presses	17.67	2	1	50	0	1e+00	Ddx25 Zfand2b
Progressive ratio test 1 breakpoint	13.02	2	0	0	0	1e+00	Ddx25 Zfand2b
Progressive ratio test 1 inactive lever presses	14.06	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 active lever presses	62.43	2	1	50	0	1e+00	Ddx25 Zfand2b
Progressive ratio test 2 breakpoint	62.77	2	1	50	0	1e+00	Ddx25 Zfand2b
Progressive ratio test 2 inactive lever presses	50.8	2	2	100	0	1e+00	Ddx25 Zfand2b
Total sessions with >9 infusions	18.87	1	0	0	0	1e+00	Ddx25
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	50	0	1e+00	Zfand2b
Short access day 1 total infusions	50.43	1	1	50	0	1e+00	Ddx25
Short access day 10 total infusions	32.96	1	1	50	0	1e+00	Ddx25
Short access total infusions	54.56	1	1	50	0	1e+00	Ddx25
Short access day 1 locomotion	129.19	1	1	50	0	1e+00	Zfand2b
Short access day 10 total locomotion	221.92	2	1	50	0	1e+00	Ddx25 Zfand2b
Short access total locomotion	209.96	1	1	50	0	1e+00	Zfand2b
Compulsive drug intake	68.39	1	1	50	0	1e+00	Zfand2b
One hour access (0.3 mA shock)	46.47	2	1	50	0	1e+00	Ddx25 Zfand2b
One hour access (shock baseline)	40.39	1	1	50	0	1e+00	Ddx25
Number of responses in last shaping day	49.28	2	2	100	0	1e+00	Ddx25 Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Bone: cortical area	7.52	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1e+00	Ddx25
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Bone: final force	5.29	1	0	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	0	1e+00	Ddx25
Bone: trabecular thickness	4.3	1	0	0	0	1e+00	Ddx25
Distance traveled before self-admin	10.87	2	0	0	0	1e+00	Ddx25 Zfand2b
Distance traveled after self-admin	10.47	2	0	0	0	1e+00	Ddx25 Zfand2b
Delta time in closed arm before/after self-admin	6.42	1	0	0	0	1e+00	Ddx25
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Extinction: sum of active levers before priming	23.79	1	0	0	0	1e+00	Ddx25
Active lever presses in extinction session 6	17.95	2	0	0	0	1e+00	Ddx25 Zfand2b
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	10.33	2	0	0	0	1e+00	Ddx25 Zfand2b
Time in closed arm before self-admin	44.32	1	1	50	0	1e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	0	1e+00	Ddx25
Time to tail flick, vehicle, after self-admin	75.62	1	1	50	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	8.28	2	0	0	0	1e+00	Ddx25 Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	50	0	1e+00	Zfand2b
Ambulatory time before self-admin	26.99	2	1	50	0	1e+00	Ddx25 Zfand2b
Ambulatory time after self-admin	5.17	2	0	0	0	1e+00	Ddx25 Zfand2b
Total heroin consumption	8.9	1	0	0	0	1e+00	Ddx25
Area under the delay curve	31.15	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	50	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	50	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	50	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	50	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	50	0	1e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	50	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	50	0	1e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	4.29	1	0	0	0	1e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	50	0	1e+00	Zfand2b
Run reversals in cocaine runway, males	8.37	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	20.07	2	1	50	0	1e+00	Ddx25 Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	50	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, M	10.76	1	0	0	0	1e+00	Ddx25
Sr content in liver	9.74	1	0	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.08
Adipose	alternative TSS	0	0	1.05
Adipose	gene expression	1	0	1.07
Adipose	isoform ratio	0	0	1.05
Adipose	intron excision ratio	0	0	1.08
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	1.18
BLA	alternative TSS	0	0	1.01
BLA	gene expression	0	0	1.09
BLA	isoform ratio	0	0	1.12
BLA	intron excision ratio	0	0	1.04
BLA	mRNA stability	0	0	1.11
Brain	alternative polyA	0	0	1.13
Brain	alternative TSS	0	0	0.99
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.06
Brain	intron excision ratio	0	0	1.05
Brain	mRNA stability	0	0	1.06
Eye	alternative polyA	0	0	1.35
Eye	alternative TSS	0	0	1.03
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.1
Eye	intron excision ratio	0	0	1.12
Eye	mRNA stability	0	0	1.15
IL	alternative polyA	0	0	1.09
IL	alternative TSS	0	0	1
IL	gene expression	0	0	1.08
IL	isoform ratio	0	0	1.04
IL	intron excision ratio	0	0	1.06
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	1.04
LHb	alternative TSS	0	0	1.16
LHb	gene expression	0	0	1.06
LHb	isoform ratio	0	0	1.11
LHb	intron excision ratio	0	0	1.02
LHb	mRNA stability	0	0	1.05
Liver	alternative polyA	0	0	1.05
Liver	alternative TSS	0	0	1.03
Liver	gene expression	0	0	1.06
Liver	isoform ratio	0	0	1.03
Liver	intron excision ratio	0	0	1.11
Liver	mRNA stability	0	0	1.09
NAcc	alternative polyA	0	0	1.19
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.07
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.04
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.08
OFC	alternative TSS	0	0	1.07
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1.05
OFC	mRNA stability	0	0	1.05
PL	alternative polyA	0	0	1.2
PL	alternative TSS	0	0	1.04
PL	gene expression	0	0	1.08
PL	isoform ratio	0	0	1.1
PL	intron excision ratio	1	0	1.08
PL	mRNA stability	0	0	1.09
pVTA	alternative polyA	0	0	1.09
pVTA	alternative TSS	0	0	1.08
pVTA	gene expression	0	0	1.1
pVTA	isoform ratio	0	0	1.07
pVTA	intron excision ratio	0	0	1.01
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	0	0	1.25
RMTg	alternative TSS	0	0	1.13
RMTg	gene expression	0	0	1.1
RMTg	isoform ratio	0	0	1.15
RMTg	intron excision ratio	0	0	1.05
RMTg	mRNA stability	0	0	1.05