Hub : Traits

Condit. Reinf. active responses

Pavlovian Conditioned Approach, conditioned reinforcement, number of active nose-poke hole entries during the test

Tags: Behavior · Learning and memory · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_shelly_flagel_2014

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	37017099	38048368	1	1	2.23e-10	8.34e-02	4.09e-05	Fmnl2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	3.85	1	0	0	0	1e+00	Fmnl2
BMI without tail	3.91	1	0	0	0	1e+00	Fmnl2
Heart weight	7.37	1	0	0	0	1e+00	Fmnl2
Length with tail	1.58	1	0	0	0	1e+00	Fmnl2
Liver weight, left	4.01	1	0	0	0	1e+00	Fmnl2
Liver weight, right	9.71	1	0	0	0	1e+00	Fmnl2
Intraocular pressure	6.72	1	0	0	0	1e+00	Fmnl2
Extensor digitorum longus weight	3.2	1	0	0	0	1e+00	Fmnl2
Soleus weight	2.69	1	0	0	0	1e+00	Fmnl2
Tibialis anterior weight	3.51	1	0	0	0	1e+00	Fmnl2
Tibia length	11.32	1	1	100	0	1e+00	Fmnl2
Number of licking bursts	7.39	1	0	0	0	1e+00	Fmnl2
Food consumed during 24 hour testing period	19.17	1	0	0	0	1e+00	Fmnl2
Mean time between licks in bursts	9.66	1	0	0	0	1e+00	Fmnl2
Mean num. licks in bursts	4	1	0	0	0	1e+00	Fmnl2
Patch foraging indifference point AUC	12.37	1	0	0	0	1e+00	Fmnl2
Patch foraging total patch changes 24 sec	5.1	1	0	0	0	1e+00	Fmnl2
Patch foraging time to switch 0 sec	6.59	1	0	0	0	1e+00	Fmnl2
Patch foraging water rate 0 sec	6.46	1	0	0	0	1e+00	Fmnl2
Patch foraging water rate 12 sec	2.54	1	0	0	0	1e+00	Fmnl2
Light reinforcement 1	3.79	1	0	0	0	1e+00	Fmnl2
Reaction time mean minus median	3.4	1	0	0	0	1e+00	Fmnl2
Reaction time mean minus median AUC	5.34	1	0	0	0	1e+00	Fmnl2
Reaction time num false alarms	6.45	1	0	0	0	1e+00	Fmnl2
Reaction time num false alarms AUC	5.09	1	0	0	0	1e+00	Fmnl2
Reaction time omissions	3.67	1	0	0	0	1e+00	Fmnl2
Social time	3.22	1	0	0	0	1e+00	Fmnl2
Conditioned locomotion	17.68	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. active minus inactive responses	8.7	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. active-inactive response ratio	11.96	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. active responses	3.52	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. lever presses	4.07	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. lever reinforcers received	4.33	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. lever latency	5.83	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. lever contacts	8.43	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. magazine entry number	3.77	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. response bias	8.66	1	0	0	0	1e+00	Fmnl2
Intermitt. access day 15 inactive lever presses	6.04	1	0	0	0	1e+00	Fmnl2
Locomotion distance, session 2	5.64	1	0	0	0	1e+00	Fmnl2
Stereotopy head waving duration, day 7	4.2	1	0	0	0	1e+00	Fmnl2
Condit. Reinf. active minus inactive responses	31.5	1	1	100	0	1e+00	Fmnl2
Condit. Reinf. active-inactive response ratio	20.61	1	0	0	0	1e+00	Fmnl2
Incentive salience index mean	35.56	1	1	100	0	1e+00	Fmnl2
Condit. Reinf. lever presses	9.61	1	0	0	0	1e+00	Fmnl2
Time in familiar zone, hab. session 1	23.73	1	0	0	0	1e+00	Fmnl2
Time in novel zone, hab. session 1	27.89	1	1	100	0	1e+00	Fmnl2
Time in novel zone, hab. session 2	8.76	1	0	0	0	1e+00	Fmnl2
Total locomotion distance, NPP test	4.56	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. lever latency	16.5	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. magazine entry latency	3.12	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. change in total contacts	5.51	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. latency score	4.01	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. lever contacts	10.35	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. intertrial magazine entries	10.71	1	0	0	0	1e+00	Fmnl2
Pavlov. Cond. lever-magazine prob. diff.	4.3	1	0	0	0	1e+00	Fmnl2
Bone: apparent density	6.31	1	0	0	0	1e+00	Fmnl2
Bone surface	5.6	1	0	0	0	1e+00	Fmnl2
Bone volume	3.2	1	0	0	0	1e+00	Fmnl2
Bone: connectivity density	7.6	1	0	0	0	1e+00	Fmnl2
Bone: endosteal estimation	2.08	1	0	0	0	1e+00	Fmnl2
Bone: marrow area	2.02	1	0	0	0	1e+00	Fmnl2
Bone: maximum diameter	3.12	1	0	0	0	1e+00	Fmnl2
Bone: periosteal estimation	2.8	1	0	0	0	1e+00	Fmnl2
Bone: post-yield work	4.8	1	0	0	0	1e+00	Fmnl2
Bone: trabecular number	2.92	1	0	0	0	1e+00	Fmnl2
Bone: trabecular thickness	5.35	1	0	0	0	1e+00	Fmnl2
Progressive ratio	3.56	1	0	0	0	1e+00	Fmnl2
Cd content in liver	11.28	1	0	0	0	1e+00	Fmnl2
Cu content in liver	3.3	1	0	0	0	1e+00	Fmnl2
Fe content in liver	5.46	1	0	0	0	1e+00	Fmnl2
Se content in liver	3.3	1	0	0	0	1e+00	Fmnl2
Sr content in liver	12.44	1	0	0	0	1e+00	Fmnl2
Zn content in liver	11.2	1	0	0	0	1e+00	Fmnl2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.25
Adipose	alternative TSS	0	0	1.25
Adipose	gene expression	0	0	1.21
Adipose	isoform ratio	0	0	1.22
Adipose	intron excision ratio	0	0	1.23
Adipose	mRNA stability	0	0	1.21
BLA	alternative polyA	0	0	1.28
BLA	alternative TSS	0	0	1.2
BLA	gene expression	0	0	1.26
BLA	isoform ratio	0	0	1.19
BLA	intron excision ratio	0	0	1.17
BLA	mRNA stability	0	0	1.3
Brain	alternative polyA	0	0	1.23
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.24
Brain	isoform ratio	0	0	1.2
Brain	intron excision ratio	0	0	1.21
Brain	mRNA stability	0	0	1.23
Eye	alternative polyA	0	0	1.09
Eye	alternative TSS	0	0	1.45
Eye	gene expression	0	0	1.18
Eye	isoform ratio	0	0	1.22
Eye	intron excision ratio	0	0	1.22
Eye	mRNA stability	0	0	1.24
IL	alternative polyA	0	0	1.21
IL	alternative TSS	1	0.2	1.29
IL	gene expression	0	0	1.26
IL	isoform ratio	0	0	1.24
IL	intron excision ratio	0	0	1.25
IL	mRNA stability	0	0	1.29
LHb	alternative polyA	0	0	1.25
LHb	alternative TSS	0	0	1.2
LHb	gene expression	0	0	1.25
LHb	isoform ratio	0	0	1.21
LHb	intron excision ratio	0	0	1.1
LHb	mRNA stability	0	0	1.27
Liver	alternative polyA	0	0	1.21
Liver	alternative TSS	0	0	1.13
Liver	gene expression	0	0	1.2
Liver	isoform ratio	0	0	1.15
Liver	intron excision ratio	0	0	1.18
Liver	mRNA stability	0	0	1.21
NAcc	alternative polyA	0	0	1.31
NAcc	alternative TSS	0	0	1.19
NAcc	gene expression	0	0	1.26
NAcc	isoform ratio	0	0	1.26
NAcc	intron excision ratio	0	0	1.25
NAcc	mRNA stability	0	0	1.26
OFC	alternative polyA	0	0	1.19
OFC	alternative TSS	0	0	1.15
OFC	gene expression	0	0	1.24
OFC	isoform ratio	0	0	1.24
OFC	intron excision ratio	0	0	1.22
OFC	mRNA stability	0	0	1.3
PL	alternative polyA	0	0	1.27
PL	alternative TSS	0	0	1.23
PL	gene expression	0	0	1.26
PL	isoform ratio	0	0	1.22
PL	intron excision ratio	0	0	1.2
PL	mRNA stability	0	0	1.29
pVTA	alternative polyA	0	0	1.2
pVTA	alternative TSS	0	0	1.24
pVTA	gene expression	0	0	1.26
pVTA	isoform ratio	0	0	1.21
pVTA	intron excision ratio	0	0	1.24
pVTA	mRNA stability	0	0	1.23
RMTg	alternative polyA	0	0	1.16
RMTg	alternative TSS	0	0	1.22
RMTg	gene expression	0	0	1.29
RMTg	isoform ratio	0	0	1.11
RMTg	intron excision ratio	0	0	1.19
RMTg	mRNA stability	0	0	1.3