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chr5:54,563,228-57,839,987

Best TWAS P=8.192008e-08 · Best GWAS P=2.064113e-08 conditioned to 0.08770264

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Aptx	isoform ratio	ENSRNOT00000115715	0.12	0.06	lasso	7	0.06	9.5e-08	4.9	5.3	9.8e-08	0.52	0.63	0.37	TRUE
2	BLA	Smim27	gene expression	ENSRNOG00000069822	0.06	0.02	blup	2227	0.04	3.9e-03	5.0	-5.3	1.1e-07	-0.76	0.59	0.29	FALSE
3	Brain	Ddx58	alternative TSS	ENSRNOT00000107881	0.07	0.05	enet	19	0.11	5.5e-10	-4.3	5.2	2.3e-07	0.51	0.83	0.16	FALSE
4	Brain	Ddx58	alternative TSS	ENSRNOT00000107968	0.07	0.05	enet	19	0.11	4.3e-10	-4.3	-5.2	2.3e-07	-0.51	0.83	0.17	FALSE
5	Brain	Ddx58	alternative TSS	ENSRNOT00000060765	0.07	0.06	enet	11	0.09	8.1e-09	-4.3	-5.3	8.8e-08	-0.64	0.84	0.16	FALSE
6	Brain	Ddx58	alternative TSS	ENSRNOT00000107881	0.07	0.06	enet	11	0.09	9.8e-09	-4.3	5.4	8.2e-08	0.64	0.82	0.17	TRUE
7	Brain	Ddx58	isoform ratio	ENSRNOT00000107881	0.06	0.07	enet	11	0.07	7.6e-07	-4.3	5.2	2.3e-07	0.67	0.88	0.12	FALSE
8	Eye	Nudt2	gene expression	ENSRNOG00000013110	0.37	0.19	top1	1	0.19	6.8e-04	5.4	-5.4	8.6e-08	-0.56	0.08	0.11	FALSE
9	IL	Phf24	gene expression	ENSRNOG00000000129	0.17	0.12	enet	6	0.14	2.6e-04	5.5	5.2	2.0e-07	0.56	0.36	0.53	FALSE
10	LHb	Aco1	gene expression	ENSRNOG00000005849	0.21	0.05	blup	2235	0.08	6.5e-03	-4.3	5.3	1.2e-07	0.69	0.62	0.21	FALSE
11	Liver	Aco1	alternative polyA	ENSRNOT00000100040	0.02	0.02	lasso	3	0.02	9.6e-04	5.0	5.2	1.7e-07	0.70	0.45	0.32	FALSE
12	Liver	Smim27	gene expression	ENSRNOG00000069822	0.03	0.03	top1	1	0.03	3.1e-04	5.2	-5.2	2.3e-07	-0.78	0.09	0.09	FALSE
13	Liver	Ddx58	intron excision ratio	chr5:55347696:55349132	0.04	0.02	blup	2296	0.03	7.9e-04	5.2	5.2	2.4e-07	0.81	0.62	0.36	FALSE
14	Liver	Ddx58	mRNA stability	ENSRNOG00000006384	0.04	0.01	blup	2296	0.01	1.2e-02	5.2	5.2	2.4e-07	0.79	0.61	0.35	FALSE
15	PL2	Ddx58	alternative TSS	ENSRNOT00000060765	0.10	0.07	blup	2296	0.08	3.9e-05	-4.2	-5.1	2.8e-07	-0.65	0.91	0.08	FALSE
16	PL2	Ddx58	alternative TSS	ENSRNOT00000107881	0.10	0.07	blup	2296	0.08	3.9e-05	-4.2	5.2	2.5e-07	0.66	0.91	0.09	FALSE
17	PL2	Aco1	gene expression	ENSRNOG00000005849	0.10	0.07	enet	119	0.07	1.2e-04	4.3	5.2	2.1e-07	0.66	0.88	0.12	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.