chr5:54,563,228-57,839,987

Trait: Extensor digitorum longus weight

Best TWAS P=8.19e-08 · Best GWAS P=2.06e-08 conditioned to 8.77e-02

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Aptx isoform ratio ENSRNOT00000115715 0.12 7 0.06 9.5e-08 5.33 9.78e-08 0.37 TRUE
BLA Smim27 gene expression ENSRNOG00000069822 0.06 2227 0.04 3.9e-03 -5.3 1.14e-07 0.29 FALSE
Brain Ddx58 alternative TSS ENSRNOT00000107881 0.07 19 0.11 5.5e-10 5.17 2.32e-07 0.16 FALSE
Brain Ddx58 alternative TSS ENSRNOT00000107968 0.07 19 0.11 4.3e-10 -5.18 2.26e-07 0.17 FALSE
Brain Ddx58 alternative TSS ENSRNOT00000060765 0.07 11 0.09 8.1e-09 -5.35 8.85e-08 0.16 FALSE
Brain Ddx58 alternative TSS ENSRNOT00000107881 0.07 11 0.09 9.8e-09 5.36 8.19e-08 0.17 TRUE
Brain Ddx58 isoform ratio ENSRNOT00000107881 0.06 11 0.07 7.6e-07 5.18 2.27e-07 0.12 FALSE
Eye Nudt2 gene expression ENSRNOG00000013110 0.37 1 0.19 6.8e-04 -5.35 8.62e-08 0.11 FALSE
IL Phf24 gene expression ENSRNOG00000000129 0.17 6 0.14 2.6e-04 5.2 1.98e-07 0.53 FALSE
LHb Aco1 gene expression ENSRNOG00000005849 0.21 2235 0.08 6.5e-03 5.3 1.16e-07 0.21 FALSE
Liver Aco1 alternative polyA ENSRNOT00000100040 0.02 3 0.02 9.6e-04 5.23 1.65e-07 0.32 FALSE
Liver Smim27 gene expression ENSRNOG00000069822 0.03 1 0.03 3.1e-04 -5.18 2.27e-07 0.09 FALSE
Liver Ddx58 intron excision ratio chr5:55347696:55349132 0.04 2296 0.03 7.9e-04 5.16 2.42e-07 0.36 FALSE
Liver Ddx58 mRNA stability ENSRNOG00000006384 0.04 2296 0.01 1.2e-02 5.17 2.37e-07 0.35 FALSE
NAcc Aptx intron excision ratio chr5:55811580:55813276 0.08 3 0.06 5.9e-05 -5.35 8.79e-08 0.64 FALSE
PL Ddx58 alternative TSS ENSRNOT00000107881 0.08 2295 0.09 2.2e-07 5.23 1.70e-07 0.08 FALSE
PL Ddx58 alternative TSS ENSRNOT00000107968 0.08 2295 0.09 1.7e-07 -5.24 1.60e-07 0.08 FALSE
PL Ddx58 alternative TSS ENSRNOT00000060765 0.1 2295 0.1 4.2e-08 -5.32 1.02e-07 0.09 FALSE
PL Ddx58 alternative TSS ENSRNOT00000107881 0.1 2295 0.1 4.1e-08 5.31 1.07e-07 0.09 FALSE
PL Ddx58 isoform ratio ENSRNOT00000060765 0.05 2295 0.05 1.2e-04 -5.12 3.08e-07 0.1 FALSE
PL Ddx58 isoform ratio ENSRNOT00000107881 0.09 2295 0.1 2.8e-08 5.21 1.89e-07 0.06 FALSE
PL Smu1 mRNA stability ENSRNOG00000007671 0.11 1 0.1 3.8e-08 -5.1 3.34e-07 0.92 FALSE