Hub : Genes

Ccdc25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000015939 0.34 0.13 0.0e+00 0.27 0.29 0.28 0.29 5.1e-30 3.7e-32 4.7e-31 6.4e-32
2 Adipose gene expression ENSRNOG00000015939 0.1 0.06 5.4e-09 0.06 0.06 0.04 0.06 4.6e-07 4.0e-07 1.3e-05 8.7e-07
3 LHb gene expression ENSRNOG00000015939 0.35 0.15 1.5e-05 0.15 0.15 0.18 0.19 2.5e-04 1.7e-04 5.8e-05 3.2e-05
4 Brain mRNA stability ENSRNOG00000015939 0.03 0.02 5.1e-03 0.01 0.02 0.01 0.01 2.8e-02 1.0e-02 5.4e-02 3.9e-02
5 Brain gene expression ENSRNOG00000015939 0.23 0.1 0.0e+00 0.3 0.3 0.3 0.31 4.5e-28 1.8e-28 1.1e-27 3.7e-29
6 NAcc gene expression ENSRNOG00000015939 0.21 0.1 4.8e-13 0.14 0.12 0.13 0.13 2.2e-10 2.5e-09 8.0e-10 1.1e-09
7 IL gene expression ENSRNOG00000015939 0.29 0.14 5.3e-05 0.14 0.13 0.12 0.01 2.7e-04 5.2e-04 9.3e-04 1.9e-01
8 BLA gene expression ENSRNOG00000015939 0.34 0.12 2.2e-15 0.22 0.16 0.2 0.13 9.1e-12 9.2e-09 8.6e-11 1.7e-07
9 BLA intron excision ratio chr15:40064340:40071614 0.18 0.12 8.5e-03 -0 0 0.02 0 7.3e-01 2.0e-01 3.7e-02 3.2e-01
10 PL gene expression ENSRNOG00000015939 0.23 0.1 5.6e-17 0.19 0.13 0.19 0.06 1.9e-14 4.8e-10 9.9e-15 2.7e-05
11 OFC gene expression ENSRNOG00000015939 0.39 0.17 2.6e-05 0.06 0.09 0.03 0.04 1.5e-02 3.8e-03 7.4e-02 3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.22.02.6-1.3-1.3-1.61.2-1.5-1.5-1.5-1.5-0.7-1.5-1.6
Area under the delay curve0.10.10.5-0.1-0.20.10.00.30.30.20.30.00.70.6
BMI with tail0.62.12.31.51.41.5-1.41.51.41.41.51.41.41.3
BMI without tail0.10.21.00.60.50.1-0.60.20.10.20.11.00.0-0.2
Body weight0.00.10.4-0.00.00.40.10.40.30.30.3-0.10.50.6
Weight adjusted by age0.20.20.8-0.7-0.50.00.70.0-0.1-0.2-0.2-0.90.10.4
Bone surface1.22.02.7-1.6-1.6-1.61.5-1.5-1.5-1.5-1.5-0.8-1.3-1.3
Bone volume1.32.23.1-1.6-1.7-1.81.5-1.5-1.5-1.5-1.5-0.9-1.2-1.2
Breakpoint value in progressive ratio session0.40.40.7-0.5-0.6-0.70.5-0.7-0.7-0.7-0.8-0.6-0.6-0.6
Number of licking bursts0.20.20.50.70.60.4-0.70.40.40.40.40.60.20.1
Context. condit. distance diff. score2.22.75.62.32.21.3-2.31.21.31.41.32.40.60.1
Locomotion velocity, session 11.01.01.7-1.0-1.1-1.01.1-1.0-1.1-1.0-1.1-1.3-0.7-0.6
Locomotion distance, session 12.63.46.0-2.0-2.2-1.72.1-1.8-1.8-1.8-1.8-2.4-1.1-0.8
Locomotion velocity, session 21.31.52.4-1.4-1.5-1.11.4-1.1-1.2-1.2-1.2-1.5-0.6-0.4
Locomotion distance, session 23.65.27.6-2.6-2.7-2.12.6-2.2-2.3-2.3-2.3-2.7-1.5-1.2
Locomotion velocity, session 31.92.22.71.51.51.6-1.41.61.51.61.51.31.31.3
Locomotion distance, session 30.70.81.11.01.00.9-1.00.90.90.90.90.90.70.6
Stereotopy head waving bouts, day 30.10.10.6-0.2-0.10.20.3-0.1-0.1-0.1-0.1-0.7-0.10.0
Stereotopy head waving duration, day 30.40.41.10.20.30.9-0.10.80.60.60.6-0.40.91.1
Locomotion velocity, session 71.71.95.12.02.00.7-2.00.80.91.00.92.30.0-0.5
Locomotion distance, session 70.50.72.50.80.7-0.5-0.9-0.3-0.2-0.2-0.21.6-0.9-1.4
Stereotopy head waving bouts, day 70.30.41.10.10.10.7-0.00.60.50.50.5-0.80.81.1
Stereotopy head waving duration, day 71.01.22.50.70.81.5-0.61.21.11.11.1-0.31.31.6
Locomotion velocity, session 80.50.60.91.00.90.9-0.90.70.70.90.70.50.70.7
Locomotion distance, session 80.10.10.30.1-0.0-0.4-0.0-0.4-0.4-0.4-0.4-0.0-0.4-0.5
Degree of sensitization distance1.11.13.6-0.2-0.2-1.40.0-1.1-0.9-1.0-0.90.8-1.5-1.9
Degree of sensitization stereotypy0.60.61.50.50.51.0-0.40.90.80.80.8-0.21.01.2
Conditioned locomotion0.10.10.20.50.40.1-0.4-0.00.00.00.00.3-0.2-0.3
Cocaine response after cond. corrected2.02.23.41.81.81.4-1.81.31.41.41.41.81.00.7
Cocaine response after cond. not corrected0.80.91.51.21.20.8-1.20.80.90.90.91.10.60.4
Cocaine response before conditioning2.32.83.6-1.9-1.9-1.71.9-1.6-1.6-1.6-1.6-1.8-1.4-1.1
Saline control response0.71.01.5-1.2-1.2-1.01.2-0.9-1.0-1.0-1.0-1.0-0.7-0.6
Bone: connectivity density2.03.16.0-1.3-1.2-1.81.3-1.9-1.9-1.9-1.9-0.8-2.3-2.4
Bone: cortical apparent density1.82.44.61.61.71.3-1.81.51.51.51.52.11.10.8
Bone: cortical area0.10.10.4-0.3-0.4-0.10.20.20.10.10.10.20.70.7
Bone: cortical porosity0.30.31.5-0.6-0.60.00.7-0.1-0.2-0.2-0.2-1.20.20.5
Bone: cortical porosity0.30.31.5-0.8-0.7-0.10.8-0.1-0.3-0.2-0.2-1.20.30.5
Bone: cortical thickness0.20.41.10.30.20.4-0.40.70.60.60.60.51.01.0
Bone: cortical thickness0.81.01.80.90.80.7-1.11.00.91.01.01.31.20.9
Bone: cortical tissue density2.12.85.01.81.81.4-1.91.61.61.61.72.21.31.0
Condit. Reinf. active minus inactive responses0.20.20.5-0.7-0.6-0.40.7-0.3-0.4-0.4-0.4-0.5-0.1-0.0
Condit. Reinf. active-inactive response ratio0.20.20.40.50.50.6-0.40.50.50.40.50.20.40.5
Condit. Reinf. active responses1.31.62.5-1.6-1.6-1.31.5-1.1-1.2-1.3-1.2-1.3-0.9-0.7
Condit. Reinf. inactive responses4.35.16.4-2.5-2.5-2.42.4-2.2-2.3-2.3-2.3-2.2-1.9-1.8
Incentive salience index mean0.50.61.3-1.2-1.1-0.61.1-0.5-0.6-0.6-0.6-1.1-0.20.1
Condit. Reinf. lever presses1.21.73.1-1.8-1.7-1.21.7-1.0-1.1-1.1-1.1-1.7-0.6-0.2
Condit. Reinf. active minus inactive responses0.60.81.0-0.8-0.9-0.80.8-0.9-0.9-0.9-0.9-1.0-0.8-0.7
Condit. Reinf. active-inactive response ratio0.30.30.50.70.70.7-0.60.60.60.60.60.20.50.5
Condit. Reinf. active responses0.91.31.5-1.0-1.1-1.21.1-1.2-1.2-1.2-1.2-1.1-1.0-1.0
Condit. Reinf. inactive responses2.73.44.2-1.7-1.8-2.11.7-2.0-2.0-2.0-2.0-1.4-1.9-1.9
Condit. Reinf. lever presses0.70.91.7-1.3-1.3-0.91.2-0.8-0.9-0.9-0.9-0.9-0.5-0.4
Condit. Reinf. lever reinforcers received0.60.81.0-0.9-0.9-0.90.9-1.0-1.0-1.0-1.0-0.9-0.8-0.7
Conditioned reinforcement - actives0.20.20.5-0.0-0.1-0.6-0.0-0.5-0.5-0.4-0.5-0.1-0.6-0.7
Conditioned reinforcement - inactives1.61.82.5-1.2-1.2-1.51.2-1.4-1.3-1.3-1.3-1.4-1.6-1.5
Conditioned locomotion0.00.00.10.30.2-0.1-0.3-0.00.00.00.0-0.1-0.2-0.2
Patch foraging indifference point 0 sec6.09.812.7-3.6-3.6-3.23.5-3.1-3.1-3.1-3.1-3.2-2.5-2.2
Patch foraging indifference point AUC4.45.26.02.42.32.4-2.42.12.42.22.41.72.42.2
Delay disc. indifference point, 0s delay2.93.14.4-1.9-2.0-1.71.9-1.7-1.8-1.8-1.8-2.1-1.4-1.3
Delay disc. indifference point, 16s delay0.40.40.80.50.40.4-0.50.60.60.60.60.80.90.7
Delay disc. indifference point, 2s delay1.41.54.2-1.5-1.6-1.01.5-1.1-1.0-1.0-1.0-2.0-0.5-0.3
Delay disc. indifference point, 24s delay0.60.61.10.50.40.6-0.60.90.80.70.80.71.10.9
Delay disc. indifference point, 4s delay0.70.81.50.50.50.8-0.61.01.00.91.00.41.21.2
Delay disc. indifference point, 8s delay0.50.50.90.40.40.5-0.50.70.70.70.70.90.90.8
Indifference point function ln k1.62.33.2-1.8-1.7-1.51.7-1.4-1.6-1.4-1.6-1.3-1.3-1.2
Indifference point function log k1.62.33.2-1.8-1.7-1.51.7-1.4-1.6-1.4-1.6-1.3-1.3-1.2
Patch foraging total patch changes 0 sec5.28.411.6-3.4-3.4-2.93.3-2.8-2.9-2.8-2.9-3.0-2.2-1.9
Patch foraging total patch changes 12 sec0.81.01.6-1.2-1.3-1.11.1-1.0-0.9-1.1-0.9-1.1-0.5-0.5
Patch foraging total patch changes 18 sec0.10.20.3-0.4-0.5-0.60.3-0.5-0.5-0.4-0.5-0.1-0.2-0.3
Patch foraging total patch changes 24 sec1.31.62.7-1.6-1.6-1.21.5-1.2-1.2-1.2-1.1-1.6-0.5-0.3
Patch foraging total patch changes 6 sec0.20.30.4-0.5-0.6-0.60.5-0.5-0.5-0.5-0.5-0.6-0.3-0.3
Patch foraging time to switch 0 sec1.01.52.2-1.1-1.0-1.41.0-1.3-1.2-1.3-1.2-0.7-1.5-1.5
Patch foraging water rate 0 sec0.10.20.70.0-0.00.40.10.40.10.30.1-0.40.70.8
Patch foraging water rate 12 sec0.10.10.2-0.5-0.4-0.00.50.1-0.2-0.0-0.2-0.40.20.4
Patch foraging water rate 18 sec2.63.55.51.41.42.0-1.32.22.02.02.01.12.32.3
Patch foraging water rate 24 sec1.11.52.21.21.21.1-1.21.31.11.31.11.51.10.9
Patch foraging water rate 6 sec0.40.52.0-0.1-0.10.70.10.80.60.60.5-0.31.21.4
Seeking ratio, delayed vs. immediate footshock2.32.63.8-1.6-1.6-1.51.6-1.5-1.6-1.6-1.7-2.0-1.8-1.4
Distance traveled before self-admin0.20.20.7-0.1-0.10.40.10.40.30.40.2-0.50.60.8
Distance traveled after self-admin0.60.71.50.60.51.0-0.50.90.80.80.7-0.21.11.2
Extensor digitorum longus weight4.819.234.83.33.34.9-3.24.84.64.64.62.05.55.9
Bone: elastic displacement2.02.23.1-1.7-1.7-1.41.8-1.4-1.5-1.5-1.5-1.8-1.1-0.9
Bone: elastic work2.83.65.9-2.4-2.4-1.82.4-1.7-1.8-1.8-1.8-2.3-1.0-0.8
Bone: endosteal estimation0.10.30.6-0.8-0.8-0.60.7-0.5-0.5-0.6-0.5-0.3-0.4-0.3
Bone: endosteal perimeter1.02.02.8-1.6-1.7-1.41.6-1.4-1.4-1.4-1.4-1.4-1.1-0.9
Epididymis fat weight0.40.91.7-0.6-0.6-1.00.6-0.9-1.1-1.0-1.0-0.6-1.1-1.3
Delta time in closed arm before/after self-admin0.20.20.4-0.2-0.1-0.30.3-0.4-0.3-0.3-0.3-0.6-0.6-0.5
Delta time in open arm before/after self-admin0.10.10.40.20.2-0.2-0.2-0.2-0.2-0.2-0.30.6-0.4-0.5
Diff in mean of infusions in LGA sessions0.10.10.4-0.3-0.20.20.40.1-0.1-0.1-0.2-0.60.00.1
Delay discount exponential model param0.40.41.2-0.2-0.1-0.50.3-0.7-0.7-0.6-0.7-0.4-1.1-1.0
Extinction: sum of active levers before priming1.01.01.7-0.7-0.8-1.10.7-1.1-1.1-1.1-1.3-0.2-1.2-1.3
Active lever presses in extinction session 60.10.10.60.30.40.1-0.40.10.20.2-0.10.8-0.1-0.2
Bone: final force0.00.10.3-0.2-0.20.00.10.20.20.20.20.20.50.5
Bone: final moment0.10.10.4-0.6-0.6-0.30.5-0.1-0.1-0.1-0.1-0.00.30.4
Food consumed during 24 hour testing period0.10.10.3-0.3-0.30.00.20.20.20.20.2-0.00.40.6
Glucose1.92.94.71.81.81.6-1.91.61.71.71.72.21.51.3
Heart weight0.00.00.1-0.10.0-0.00.00.1-0.00.0-0.10.3-0.0-0.0
Delay discount hyperbolic model param0.30.41.1-0.00.0-0.40.1-0.6-0.6-0.6-0.6-0.1-1.1-1.0
Intermittent access intake day 1-15 change0.20.20.3-0.4-0.4-0.40.4-0.5-0.5-0.5-0.5-0.4-0.6-0.6
Intermittent access intake escalation0.10.10.1-0.2-0.2-0.10.2-0.3-0.3-0.2-0.2-0.2-0.2-0.3
Intermittent access intake escalation 20.00.00.1-0.2-0.2-0.10.2-0.3-0.2-0.2-0.2-0.1-0.2-0.2
Intermitt. access day 1 inactive lever presses0.20.21.00.00.1-0.40.0-0.5-0.2-0.4-0.3-0.3-1.0-1.0
Intermitt. access day 15 inactive lever presses0.10.10.20.30.40.4-0.20.30.50.30.30.10.00.1
Intermitt. access escalation Index0.00.00.00.10.0-0.0-0.10.0-0.00.1-0.10.2-0.10.1
Intermittent access day 1 total infusions1.21.41.71.21.11.0-1.21.21.31.21.21.21.21.1
Intermittent access day 15 total infusions0.40.50.80.80.80.6-0.80.60.70.60.70.90.50.4
Intermittent access terminal intake (last 3 days)1.82.02.51.41.41.3-1.41.31.51.41.51.61.31.2
Intermittent access total infusions1.01.11.71.31.20.9-1.30.91.11.01.01.30.80.6
Intermittent access day 1 locomotion0.00.00.1-0.1-0.2-0.30.1-0.1-0.1-0.2-0.2-0.3-0.1-0.1
Intermittent access day 15 total locomotion0.40.50.80.80.80.6-0.80.70.70.70.70.90.50.3
Intermittent access total locomotion0.00.00.10.20.20.1-0.20.20.20.20.10.00.10.1
Intermittent access standard deviation0.30.40.70.30.40.8-0.30.60.50.60.60.40.80.8
Left kidney weight0.41.32.10.70.91.3-0.71.41.11.31.20.91.21.5
Right kidney weight0.51.32.1-1.4-1.3-1.01.5-0.9-1.2-1.0-1.1-1.4-1.0-0.7
Cocaine induced anxiety0.60.71.4-1.2-1.1-0.71.2-0.6-0.7-0.7-0.7-1.0-0.5-0.2
Post-drug Anxiety2.83.14.0-1.6-1.6-1.91.6-1.9-1.8-1.9-1.9-1.0-2.0-2.0
Baseline Anxiety1.61.62.6-1.0-1.0-1.51.0-1.5-1.4-1.4-1.4-0.5-1.4-1.6
Tail length0.72.32.7-1.5-1.5-1.61.5-1.5-1.6-1.5-1.6-1.2-1.5-1.5
Length with tail0.41.52.4-1.5-1.4-1.01.5-1.0-1.2-1.0-1.2-1.5-0.9-0.6
Length without tail0.20.41.5-0.2-0.10.70.30.60.60.50.6-0.60.91.2
Times rat made contact with spout0.10.10.30.40.30.2-0.40.30.30.30.30.50.40.3
Lifetime Intake0.40.50.80.90.80.6-0.90.60.80.70.60.70.50.5
Liver weight, left3.86.17.92.02.12.7-2.02.72.62.72.62.02.72.8
Liver weight, right1.82.94.71.41.41.8-1.41.81.71.81.71.32.12.2
Locomotor activity1.82.96.9-2.3-2.2-1.32.3-1.3-1.4-1.4-1.3-2.6-0.6-0.1
Locomotor testing distance6.610.915.7-3.8-3.7-3.23.7-3.1-3.2-3.3-3.2-4.0-2.5-2.1
Locomotor testing rearing11.017.222.8-4.6-4.5-4.04.6-4.0-4.1-4.1-4.1-4.8-3.5-3.0
Locomotion in novel chamber0.10.10.20.20.10.1-0.20.40.30.30.30.30.40.3
Locomotion in novel chamber post-restriction0.70.81.60.80.71.1-0.70.90.80.80.80.41.21.3
Fecal boli incidents, locomotor time 11.51.72.80.70.81.1-0.91.61.61.31.41.01.71.7
Change in fecal boli incidents, locomotor task0.20.10.70.30.30.0-0.2-0.1-0.30.1-0.10.8-0.5-0.6
Time >=10cm from walls, locomotor time 11.21.21.6-1.1-1.0-1.01.1-1.3-1.2-1.0-1.0-0.9-1.1-1.2
Bouts of movement, locomotor time 10.80.81.51.01.01.2-0.81.00.90.90.8-0.40.81.0
Total resting periods, locomotor time 11.71.92.91.61.51.7-1.41.41.41.41.30.21.21.3
Rest time, locomotor task time 12.22.43.11.71.61.8-1.61.61.61.71.41.01.51.5
Distance moved, locomotor task time 11.51.72.4-1.3-1.3-1.51.3-1.4-1.4-1.5-1.2-0.3-1.3-1.4
Vertical activity count, locomotor time 11.81.83.3-1.8-1.8-1.31.8-1.3-1.2-1.3-1.0-1.4-0.7-0.5
Time >=10cm from walls, locomotor time 20.00.00.1-0.10.00.20.10.10.10.20.30.20.10.2
Bouts of movement, locomotor time 21.61.82.11.41.41.4-1.41.41.31.31.21.21.31.2
Total resting periods, locomotor time 23.63.94.42.12.12.1-2.02.11.92.01.81.81.91.8
Rest time, locomotor task time 29.611.112.63.33.33.4-3.33.63.43.53.32.93.43.2
Distance moved, locomotor task time 24.65.36.6-2.6-2.5-2.52.5-2.5-2.4-2.4-2.2-1.3-2.1-2.0
Vertical activity count, locomotor time 23.43.76.3-2.5-2.5-1.92.4-1.9-1.8-1.8-1.7-1.9-1.2-0.9
Light reinforcement 10.30.61.3-0.4-0.4-1.00.3-0.8-0.8-0.9-0.80.4-0.9-1.1
Light reinforcement 21.31.74.41.61.61.0-1.71.11.11.11.22.10.70.3
Bone: marrow area0.20.40.7-0.8-0.8-0.70.8-0.6-0.6-0.6-0.6-0.4-0.4-0.4
Bone: maximum diameter0.20.51.30.30.20.6-0.30.70.60.60.70.41.11.2
Bone: maximum force0.10.20.7-0.4-0.5-0.10.30.20.10.10.20.10.80.8
Bone: maximum moment0.20.31.0-0.9-1.0-0.50.8-0.1-0.2-0.2-0.2-0.20.50.6
Mean time between licks in bursts2.94.16.5-1.6-1.6-2.21.6-2.2-2.2-2.2-2.2-1.1-2.5-2.6
Mean num. licks in bursts0.00.00.1-0.3-0.3-0.10.2-0.1-0.1-0.1-0.1-0.10.10.2
Cd content in liver0.10.20.3-0.4-0.3-0.50.3-0.4-0.4-0.4-0.4-0.3-0.4-0.5
Co content in liver2.32.83.31.61.51.7-1.61.71.71.61.71.41.81.8
Cu content in liver1.01.21.61.11.11.3-1.01.11.21.11.20.81.11.1
Fe content in liver0.20.31.1-0.1-0.0-0.40.2-0.6-0.5-0.5-0.5-0.1-1.0-1.0
K content in liver0.20.20.5-0.1-0.2-0.50.1-0.5-0.5-0.4-0.50.1-0.6-0.7
Mg content in liver0.20.20.3-0.1-0.2-0.40.1-0.5-0.5-0.4-0.5-0.2-0.5-0.6
Mn content in liver2.02.32.9-1.2-1.3-1.71.2-1.7-1.7-1.6-1.7-0.8-1.7-1.7
Na content in liver1.11.23.6-1.6-1.5-0.41.6-0.5-0.7-0.6-0.7-1.90.10.5
Rb content in liver0.30.41.40.80.90.4-0.80.40.40.50.41.20.0-0.2
Se content in liver5.36.48.1-2.7-2.6-2.42.7-2.5-2.5-2.6-2.5-2.8-2.3-2.0
Sr content in liver1.21.11.6-0.8-0.8-1.00.8-1.1-1.1-1.1-1.1-1.1-1.3-1.2
Zn content in liver0.40.41.4-0.9-0.8-0.20.9-0.3-0.4-0.4-0.4-1.2-0.00.3
Bone: minimum diameter0.20.41.1-1.0-1.1-0.50.9-0.3-0.3-0.4-0.3-0.60.30.5
Time in familiar zone, hab. session 10.10.10.1-0.1-0.2-0.20.1-0.3-0.3-0.2-0.3-0.1-0.2-0.3
Time in novel zone, hab. session 12.42.32.81.41.51.6-1.41.61.71.61.71.31.51.5
Total zone transitions, hab. session 10.30.51.1-0.9-1.0-0.50.9-0.5-0.5-0.5-0.5-1.00.10.3
Total locomotion distance, hab. session 11.42.03.2-1.6-1.8-1.41.6-1.3-1.4-1.4-1.4-1.8-0.8-0.7
Locomotion velocity, hab. session 13.34.76.7-2.5-2.6-2.22.5-2.1-2.2-2.1-2.2-2.5-1.5-1.2
Time in familiar zone, hab. session 20.80.81.31.11.10.9-1.10.70.80.90.81.10.50.3
Time in novel zone, hab. session 20.50.50.9-0.9-0.9-0.70.9-0.6-0.6-0.7-0.6-1.0-0.3-0.2
Total zone transitions, hab. session 20.40.51.6-1.0-1.0-0.31.0-0.4-0.5-0.4-0.5-1.30.10.5
Total locomotion distance, hab. session 20.50.71.6-1.0-1.1-0.61.0-0.7-0.8-0.7-0.8-1.3-0.3-0.1
Locomotion velocity, hab. session 20.50.72.0-1.1-1.2-0.61.1-0.6-0.8-0.7-0.8-1.4-0.10.1
Novel to familiar place preference ratio0.70.71.3-1.1-1.1-1.11.0-0.8-0.8-0.9-0.8-0.6-0.5-0.5
Novelty place preference0.91.01.5-1.2-1.2-1.21.1-0.9-0.9-1.0-0.9-0.8-0.7-0.7
Time in novel zone, NPP test0.91.01.5-1.2-1.2-1.11.1-0.9-0.9-1.0-0.9-0.9-0.7-0.6
Total zone transitions, NPP test1.92.83.8-1.7-1.9-1.61.8-1.7-1.8-1.7-1.8-1.9-1.2-1.0
Total locomotion distance, NPP test6.08.39.4-2.8-2.9-3.02.8-3.0-3.1-3.0-3.1-2.7-2.7-2.6
Locomotion velocity, NPP test4.66.67.6-2.5-2.6-2.72.5-2.7-2.7-2.7-2.7-2.3-2.4-2.3
Intraocular pressure1.52.12.6-1.3-1.3-1.51.3-1.6-1.6-1.5-1.6-0.9-1.6-1.6
Delta distance traveled before/after self-admin1.01.11.51.11.11.2-1.11.11.11.11.00.71.11.0
Delta ambulatory time before/after self-admin0.70.81.10.80.81.0-0.80.90.90.90.90.41.01.0
Parametrial fat weight1.63.15.3-1.3-1.4-2.11.2-2.0-1.9-2.0-1.9-0.5-1.9-2.3
Pavlov. Cond. lever latency0.30.30.80.90.80.5-0.80.30.40.40.40.80.20.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.00.10.2-0.00.20.10.20.10.20.00.1
Pavlov. Cond. change in total contacts0.30.31.2-0.5-0.50.20.50.40.30.30.3-0.60.81.1
Pavlov. Cond. index score0.10.10.2-0.3-0.20.10.30.20.10.20.1-0.40.30.4
Pavlov. Cond. latency score0.10.10.3-0.5-0.4-0.10.40.0-0.1-0.0-0.1-0.50.10.2
Pavlov. Cond. lever contacts0.10.10.4-0.5-0.4-0.10.50.0-0.1-0.1-0.1-0.60.00.2
Pavlov. Cond. magazine entry number0.20.20.6-0.1-0.2-0.60.2-0.6-0.5-0.6-0.5-0.1-0.6-0.8
Pavlov. Cond. intertrial magazine entries1.51.92.6-1.6-1.6-1.41.5-1.3-1.3-1.4-1.3-1.3-1.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.2-0.10.40.10.40.30.40.3-0.30.50.7
Pavlov. Cond. response bias0.40.50.90.40.50.8-0.40.90.70.80.70.40.80.9
Pavlov. Cond. lever latency0.10.20.70.20.1-0.4-0.2-0.4-0.3-0.3-0.30.3-0.6-0.8
Pavlov. Cond. magazine entry latency0.10.10.4-0.6-0.6-0.30.6-0.2-0.2-0.2-0.2-0.20.00.1
Pavlov. Cond. change in total contacts0.50.72.10.10.20.9-0.10.90.80.80.80.21.31.5
Pavlov. Cond. index score0.10.10.5-0.5-0.40.20.50.20.10.10.1-0.40.50.7
Pavlov. Cond. latency score0.20.20.6-0.8-0.7-0.10.8-0.1-0.2-0.2-0.2-0.70.10.4
Pavlov. Cond. lever contacts0.20.30.6-0.8-0.7-0.00.80.0-0.1-0.1-0.1-0.80.40.6
Pavlov. Cond. magazine entry number0.30.40.80.90.90.6-0.80.50.60.60.60.50.30.2
Pavlov. Cond. intertrial magazine entries5.26.79.8-2.0-2.1-2.82.0-2.8-2.7-2.7-2.7-1.9-3.1-3.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.4-0.30.30.40.30.20.20.2-0.30.60.8
Pavlov. Cond. response bias0.20.30.7-0.9-0.8-0.10.8-0.0-0.1-0.1-0.1-0.80.40.7
Time in closed arm before self-admin0.30.30.50.50.50.7-0.40.60.50.60.50.30.70.7
Time in closed arm after self-admin0.10.10.3-0.4-0.3-0.20.4-0.2-0.3-0.2-0.2-0.6-0.3-0.2
Time in open arm before self-admin0.30.30.7-0.7-0.8-0.60.7-0.5-0.6-0.5-0.6-0.9-0.2-0.2
Time in open arm after self-admin0.10.10.30.10.1-0.2-0.1-0.3-0.2-0.2-0.40.2-0.4-0.5
Bone: periosteal estimation0.10.20.6-0.7-0.7-0.50.6-0.3-0.3-0.3-0.3-0.20.10.1
Bone: periosteal perimeter0.50.91.5-1.1-1.2-1.01.1-0.9-0.9-0.9-0.9-0.9-0.5-0.4
Bone: post-yield work2.02.85.81.61.41.2-1.81.61.61.61.62.41.81.5
Progressive ratio test 1 active lever presses3.33.44.52.01.91.7-2.01.81.91.81.82.11.71.5
Progressive ratio test 1 breakpoint3.43.55.32.02.01.7-2.11.82.01.81.82.31.71.4
Progressive ratio test 1 inactive lever presses0.10.20.5-0.1-0.1-0.40.1-0.4-0.3-0.3-0.40.4-0.6-0.7
Progressive ratio test 2 active lever presses2.32.53.51.71.71.5-1.71.61.51.61.51.91.31.1
Progressive ratio test 2 breakpoint1.92.12.71.51.51.4-1.51.51.41.51.41.61.21.1
Progressive ratio test 2 inactive lever presses0.20.30.50.60.60.4-0.60.50.60.50.40.70.20.2
Incentive Sensitization - Responses0.20.20.30.20.30.5-0.30.60.40.50.50.20.40.5
Incentive Sensitization - Breakpoint0.10.10.20.10.10.3-0.10.40.30.40.30.00.30.3
Sum of active levers in priming session hrs 5-60.20.20.80.60.60.1-0.60.10.10.2-0.00.9-0.1-0.4
Progressive ratio0.20.20.60.20.20.6-0.10.60.50.50.6-0.30.60.8
Food seeking constrained by brief footshock2.53.15.52.32.31.9-2.21.71.61.81.51.21.11.0
Seeking ratio, punishment vs. effort0.50.71.41.21.20.8-1.20.60.60.80.60.90.40.2
Retroperitoneal fat weight0.10.20.70.10.0-0.4-0.1-0.4-0.5-0.4-0.5-0.0-0.5-0.8
Reaction time number correct0.10.20.70.50.50.3-0.50.40.20.40.10.80.10.0
Reaction time mean minus median0.20.30.5-0.7-0.6-0.40.7-0.5-0.5-0.4-0.6-0.6-0.4-0.3
Reaction time mean minus median AUC0.10.10.2-0.4-0.3-0.30.4-0.4-0.4-0.2-0.4-0.3-0.4-0.3
Reaction time num false alarms0.60.81.1-1.1-1.1-0.81.0-0.9-1.0-0.8-1.0-0.9-0.6-0.6
Reaction time num false alarms AUC0.20.30.6-0.7-0.7-0.40.7-0.4-0.6-0.3-0.6-0.5-0.1-0.1
Reaction time trials correct on left0.10.20.70.50.50.3-0.50.40.20.40.10.80.10.0
Reaction time trials on left0.10.20.70.50.50.3-0.50.30.10.30.10.80.0-0.1
Reaction time mean0.00.00.10.10.20.3-0.00.00.10.20.1-0.2-0.00.0
Reaction time mean AUC0.00.00.1-0.10.00.20.2-0.1-0.00.10.0-0.3-0.10.0
Median of all reaction times0.10.10.30.40.50.5-0.30.30.30.40.30.10.10.1
Reaction time omissions1.52.03.3-1.1-1.1-1.61.0-1.5-1.6-1.4-1.5-0.6-1.8-1.8
Reaction time false alarm rate0.20.20.5-0.7-0.7-0.40.6-0.4-0.4-0.4-0.4-0.6-0.1-0.1
Reaction time premature initiation rate0.40.61.00.80.81.0-0.60.70.80.80.7-0.00.70.8
Reaction time premature initiations0.60.91.41.11.01.2-0.90.90.91.00.80.50.80.9
Std. dev. reaction times0.00.00.00.00.10.10.0-0.0-0.00.1-0.1-0.0-0.0-0.0
Reaction time trials completed0.10.20.70.50.50.3-0.50.30.10.30.10.80.0-0.1
Reaction time trials AUC0.10.10.60.50.50.3-0.50.30.10.30.10.80.1-0.0
Run reversals in cocaine runway, females0.40.40.6-0.2-0.3-0.60.3-0.8-0.7-0.7-0.6-0.6-0.7-0.8
Run reversals in cocaine runway, males4.34.28.11.51.42.3-1.42.32.12.12.11.22.52.8
Latency to leave start box in cocaine runway0.70.81.40.80.91.2-0.71.10.81.10.80.50.81.0
Latency to leave start box in cocaine runway, F1.41.62.41.01.01.6-0.91.41.31.41.30.61.21.5
Latency to leave start box in cocaine runway, M0.70.71.2-0.5-0.5-0.80.6-0.8-1.0-0.8-1.0-0.6-1.1-1.0
Std. dev. time between licks in bursts8.910.611.6-3.2-3.2-3.43.2-3.4-3.4-3.4-3.4-3.0-3.1-3.0
Total sessions with >9 infusions0.10.10.40.10.1-0.3-0.1-0.4-0.3-0.3-0.30.1-0.6-0.7
Short access day 1 total inactive lever presses1.71.82.51.61.51.3-1.51.31.51.41.40.81.31.1
Short access day 10 total inactive lever presses0.10.10.50.10.1-0.4-0.1-0.4-0.1-0.3-0.20.2-0.6-0.7
Short access day 1 total infusions0.80.91.61.31.20.9-1.20.90.90.90.80.70.50.5
Short access day 10 total infusions0.30.31.10.20.00.4-0.20.50.60.50.50.10.91.0
Short access total infusions0.20.30.40.50.50.5-0.50.50.60.50.50.30.50.5
Short access day 1 locomotion0.00.00.1-0.4-0.3-0.00.3-0.00.0-0.1-0.1-0.3-0.10.1
Short access day 10 total locomotion0.60.71.4-0.7-0.7-0.80.8-0.8-0.7-0.8-0.8-1.2-0.9-0.8
Short access total locomotion0.80.81.1-0.8-0.8-0.90.9-0.9-0.8-0.9-0.9-1.1-0.9-0.8
One hour access (0.3 mA shock)0.20.30.40.40.30.3-0.50.50.60.50.60.60.60.6
Compulsive drug intake0.60.61.0-0.8-0.9-1.00.8-0.8-0.8-0.8-0.8-0.6-0.7-0.6
One hour access (shock baseline)0.70.81.01.00.90.9-0.90.91.00.91.00.50.90.8
Social response proportion0.70.81.81.31.30.7-1.30.60.60.70.51.30.1-0.2
Social responses2.53.26.2-1.2-1.2-1.81.2-1.9-2.1-1.8-2.1-0.7-2.2-2.5
Social time1.21.62.0-1.4-1.3-1.21.3-1.3-1.2-1.4-1.2-1.3-1.1-1.1
Soleus weight0.51.51.81.21.11.3-1.11.31.21.21.21.11.31.3
Bone: stiffness0.40.61.00.60.50.7-0.60.80.80.80.80.71.01.0
Tibialis anterior weight3.010.520.62.32.33.7-2.13.63.33.43.41.44.24.5
Time to tail flick, vehicle, before self-admin0.20.20.3-0.5-0.5-0.50.5-0.3-0.4-0.4-0.4-0.3-0.3-0.3
Time to tail flick, vehicle, after self-admin1.21.31.81.11.11.3-1.11.11.11.21.10.91.11.1
Time to tail flick, test, before self-admin0.60.61.0-0.8-0.9-0.80.8-0.9-0.8-0.9-0.6-1.0-0.4-0.5
Time to tail flick, test, after self-admin1.21.24.3-0.1-0.1-1.20.1-1.3-1.1-1.1-0.80.6-1.6-2.1
Delta time to tail flick, vehicle, before/after SA1.41.42.01.31.31.2-1.31.01.11.11.21.40.90.8
Delta time to tail flick, test, before/after SA0.80.73.01.11.10.2-1.10.20.30.40.31.7-0.5-0.8
Tibia length2.56.99.6-3.1-2.9-2.63.0-2.5-2.5-2.6-2.5-2.7-2.2-1.9
Ambulatory time before self-admin0.10.10.5-0.0-0.10.30.10.40.30.30.2-0.40.50.7
Ambulatory time after self-admin0.80.92.20.60.51.2-0.51.10.91.00.9-0.41.31.5
Bone: tissue strength0.50.50.8-0.9-0.9-0.80.8-0.6-0.6-0.7-0.7-0.3-0.4-0.4
Total heroin consumption0.70.81.90.30.40.9-0.51.01.01.00.90.41.21.4
Bone: trabecular number1.52.43.5-1.3-1.3-1.71.2-1.7-1.6-1.7-1.6-1.0-1.8-1.9
Bone: trabecular spacing1.11.42.80.90.91.4-0.81.31.21.21.20.51.51.7
Bone: trabecular thickness0.50.61.0-0.9-1.0-1.00.8-0.7-0.8-0.8-0.7-0.5-0.5-0.5
Bone: trabecular tissue density0.50.71.20.50.50.8-0.50.90.90.90.90.71.01.1
Water consumed over 24 hours0.20.31.00.20.10.6-0.10.50.50.50.5-0.10.81.0
Number of responses in last shaping day0.30.30.7-0.8-0.8-0.40.8-0.3-0.3-0.4-0.4-0.7-0.10.1