| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | mRNA stability | ENSRNOG00000010099 | 0.1340 | 0.0750 | 0.0e+00 | 0.169 | 0.169 | 0.161 | 0.170 | 2.3e-18 | 2.5e-18 | 1.5e-17 | 1.9e-18 |
| 2 | Brain | gene expression | ENSRNOG00000010099 | 0.0460 | 0.0340 | 1.8e-05 | 0.059 | 0.056 | 0.056 | 0.055 | 3.9e-06 | 6.8e-06 | 6.3e-06 | 7.8e-06 |
| 3 | Brain | mRNA stability | ENSRNOG00000010099 | 0.0944 | 0.0553 | 5.4e-13 | 0.139 | 0.140 | 0.135 | 0.136 | 8.1e-13 | 6.3e-13 | 1.7e-12 | 1.4e-12 |
| 4 | Liver | gene expression | ENSRNOG00000010099 | 0.0620 | 0.0450 | 1.3e-07 | 0.043 | 0.043 | 0.042 | 0.038 | 1.5e-05 | 1.3e-05 | 1.9e-05 | 4.0e-05 |
| 5 | NAcc | gene expression | ENSRNOG00000010099 | 0.0520 | 0.0400 | 1.4e-04 | 0.048 | 0.046 | 0.046 | 0.050 | 1.8e-04 | 2.5e-04 | 2.2e-04 | 1.2e-04 |
| 6 | PL | gene expression | ENSRNOG00000010099 | 0.0321 | 0.0289 | 5.0e-03 | 0.021 | 0.017 | 0.017 | 0.015 | 9.5e-03 | 1.8e-02 | 1.6e-02 | 2.5e-02 |
| 7 | PL | intron excision ratio | chr7:129267287:129268793 | 0.0811 | 0.0623 | 3.5e-03 | 0.003 | 0.019 | 0.025 | 0.022 | 1.8e-01 | 1.2e-02 | 5.1e-03 | 7.9e-03 |
| 8 | PL | intron excision ratio | chr7:129268956:129271550 | 0.0337 | 0.0268 | 2.1e-03 | 0.029 | 0.034 | 0.027 | 0.027 | 2.8e-03 | 1.2e-03 | 3.6e-03 | 3.9e-03 |
| 9 | PL | mRNA stability | ENSRNOG00000010099 | 0.0464 | 0.0353 | 4.6e-04 | 0.037 | 0.038 | 0.037 | 0.036 | 8.0e-04 | 6.6e-04 | 8.2e-04 | 9.7e-04 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: stiffness | 15.4 | 24.3 | 27.1 | -5.2 | 5.1 | -5.1 | -5.0 | -4.7 | -5.0 | -4.0 | 5.1 | -5.0 |
| Bone: maximum force | 12.5 | 21.7 | 25.3 | -5.0 | 4.7 | -4.8 | -4.7 | -4.4 | -4.7 | -3.9 | 4.8 | -4.7 |
| Bone: maximum moment | 12.4 | 21.6 | 25.3 | -5.0 | 4.6 | -4.8 | -4.7 | -4.4 | -4.7 | -4.0 | 4.8 | -4.7 |
| Bone: periosteal estimation | 11.6 | 23.7 | 26.6 | -5.2 | 5.0 | -5.1 | -5.0 | -4.7 | -5.0 | -3.6 | 5.0 | -5.0 |
| Bone surface | 10.7 | 18.9 | 21.0 | -4.6 | 4.5 | -4.4 | -4.3 | -3.9 | -4.2 | -4.2 | 4.6 | -4.3 |
| Bone: periosteal perimeter | 10.3 | 17.1 | 19.2 | -4.3 | 4.1 | -4.3 | -4.2 | -3.8 | -4.4 | -3.5 | 4.3 | -4.2 |
| Bone: cortical area | 9.9 | 15.0 | 17.1 | -4.1 | 3.9 | -4.0 | -4.0 | -3.7 | -3.9 | -3.2 | 4.0 | -4.0 |
| Reaction time omissions | 9.6 | 13.0 | 14.3 | 3.7 | -3.8 | 3.8 | 3.8 | 3.6 | 3.7 | 2.4 | -3.7 | 3.8 |
| Bone: final force | 9.6 | 15.7 | 17.9 | -4.2 | 3.9 | -4.0 | -4.0 | -3.5 | -4.1 | -3.7 | 4.2 | -4.0 |
| Bone: final moment | 9.6 | 15.8 | 18.1 | -4.3 | 3.9 | -4.0 | -3.9 | -3.5 | -4.1 | -3.8 | 4.2 | -3.9 |
| Bone: apparent density | 9.0 | 14.8 | 17.3 | -4.2 | 4.1 | -3.8 | -3.8 | -3.4 | -3.5 | -4.1 | 4.0 | -3.7 |
| Intraocular pressure | 8.5 | 11.9 | 16.8 | 3.5 | -3.1 | 3.6 | 3.4 | 3.1 | 4.1 | 3.2 | -3.7 | 3.4 |
| Bone: minimum diameter | 8.3 | 15.3 | 17.4 | -4.2 | 4.0 | -4.1 | -4.1 | -4.0 | -3.8 | -2.6 | 4.0 | -4.1 |
| Reaction time mean minus median | 8.0 | 10.5 | 12.7 | 3.4 | -3.0 | 3.5 | 3.5 | 3.6 | 3.4 | 1.3 | -3.3 | 3.5 |
| Bone volume | 7.7 | 13.1 | 15.3 | -3.9 | 3.7 | -3.6 | -3.6 | -3.3 | -3.4 | -3.6 | 3.8 | -3.6 |
| Social responses | 7.6 | 9.9 | 11.1 | 3.3 | -2.8 | 3.2 | 3.1 | 3.1 | 3.3 | 3.0 | -3.3 | 3.1 |
| Length without tail | 7.4 | 16.1 | 18.5 | -4.0 | 3.9 | -4.1 | -4.0 | -3.6 | -4.3 | -4.0 | 4.3 | -4.0 |
| Bone: post-yield work | 7.3 | 9.9 | 12.1 | -3.2 | 3.3 | -3.3 | -3.3 | -3.2 | -3.5 | -1.6 | 3.2 | -3.3 |
| Body weight | 7.0 | 29.7 | 33.1 | -5.5 | 5.5 | -5.6 | -5.5 | -5.3 | -5.8 | -4.8 | 5.7 | -5.5 |
| Tibia length | 6.9 | 19.4 | 24.5 | -4.7 | 5.0 | -4.5 | -4.6 | -4.4 | -4.0 | -3.2 | 4.4 | -4.6 |
| Bone: endosteal estimation | 6.8 | 14.8 | 16.8 | -4.0 | 3.9 | -4.0 | -4.0 | -3.8 | -4.1 | -2.4 | 3.9 | -4.0 |
| Bone: marrow area | 6.8 | 14.6 | 17.0 | -4.0 | 3.8 | -4.0 | -4.0 | -3.8 | -4.1 | -2.4 | 3.9 | -4.0 |
| Bone: endosteal perimeter | 6.7 | 13.7 | 15.2 | -3.9 | 3.7 | -3.9 | -3.9 | -3.7 | -3.8 | -2.5 | 3.8 | -3.9 |
| Bone: connectivity density | 6.4 | 10.0 | 13.2 | -3.3 | 3.4 | -3.1 | -3.0 | -2.6 | -3.0 | -3.6 | 3.3 | -3.0 |
| Reaction time mean minus median AUC | 6.0 | 7.7 | 9.2 | 2.9 | -2.6 | 3.0 | 3.0 | 3.0 | 3.0 | 1.2 | -2.8 | 3.0 |
| Std. dev. reaction times | 5.8 | 8.0 | 9.5 | 2.9 | -2.6 | 3.0 | 3.1 | 3.0 | 3.1 | 1.2 | -2.9 | 3.1 |
| Extensor digitorum longus weight | 5.1 | 20.6 | 26.8 | -4.7 | 4.3 | -4.8 | -4.7 | -4.4 | -5.2 | -3.1 | 4.7 | -4.7 |
| Locomotion distance, session 3 | 5.1 | 5.5 | 7.0 | 2.3 | -2.6 | 2.4 | 2.5 | 2.4 | 2.4 | 1.5 | -2.4 | 2.5 |
| Bone: trabecular number | 5.1 | 7.9 | 14.3 | -3.0 | 3.1 | -2.6 | -2.5 | -2.0 | -2.5 | -3.8 | 2.9 | -2.5 |
| BMI with tail | 4.9 | 15.9 | 17.7 | -3.8 | 4.2 | -4.0 | -3.9 | -3.6 | -4.1 | -4.2 | 4.2 | -3.9 |
| Cocaine response before conditioning | 4.9 | 6.0 | 8.8 | 2.4 | -2.0 | 2.5 | 2.3 | 2.1 | 3.0 | 2.7 | -2.7 | 2.4 |
| Bone: elastic displacement | 4.8 | 5.4 | 6.1 | 2.3 | -2.4 | 2.4 | 2.3 | 2.1 | 2.5 | 2.1 | -2.4 | 2.4 |
| Reaction time premature initiation rate | 4.6 | 6.1 | 7.0 | 2.5 | -2.5 | 2.5 | 2.5 | 2.3 | 2.3 | 2.6 | -2.6 | 2.4 |
| Bone: maximum diameter | 4.5 | 8.2 | 9.4 | -3.0 | 3.0 | -3.0 | -3.0 | -2.8 | -3.1 | -1.9 | 2.9 | -3.0 |
| Bone: cortical thickness | 4.2 | 7.0 | 7.8 | -2.8 | 2.6 | -2.7 | -2.7 | -2.5 | -2.6 | -2.5 | 2.8 | -2.7 |
| Post-drug Anxiety | 4.1 | 4.5 | 5.2 | -2.1 | 2.2 | -2.2 | -2.3 | -2.2 | -2.1 | -1.4 | 2.2 | -2.3 |
| Delta time in open arm before/after self-admin | 4.0 | 3.8 | 4.3 | 2.0 | -2.1 | 1.9 | 1.9 | 1.8 | 2.0 | 2.0 | -2.0 | 1.9 |
| Pavlov. Cond. intertrial magazine entries | 3.9 | 5.0 | 6.6 | 2.5 | -2.6 | 2.3 | 2.4 | 2.4 | 1.8 | 1.5 | -2.2 | 2.3 |
| Delay discounting water rate 6 sec | 3.8 | 5.5 | 6.3 | -2.4 | 2.1 | -2.5 | -2.5 | -2.4 | -2.4 | -1.7 | 2.5 | -2.5 |
| Ambulatory time before self-admin | 3.8 | 3.9 | 5.4 | 2.0 | -2.0 | 1.9 | 1.9 | 1.7 | 2.0 | 2.3 | -2.1 | 1.9 |
| Delay discounting water rate 0 sec | 3.7 | 5.9 | 7.0 | -2.6 | 2.3 | -2.6 | -2.5 | -2.4 | -2.6 | -1.7 | 2.5 | -2.5 |
| Delay discounting total patch changes 18 sec | 3.5 | 4.6 | 7.2 | 1.9 | -2.0 | 2.1 | 2.1 | 1.8 | 2.1 | 2.7 | -2.3 | 2.1 |
| Delay discounting water rate 12 sec | 3.5 | 5.2 | 5.9 | -2.4 | 2.2 | -2.4 | -2.4 | -2.3 | -2.4 | -1.5 | 2.4 | -2.4 |
| Intermitt. access day 1 inactive lever presses | 3.5 | 3.8 | 7.9 | 1.8 | -1.9 | 1.8 | 1.8 | 1.5 | 1.9 | 2.8 | -2.1 | 1.8 |
| Progressive ratio test 1 active lever presses | 3.5 | 3.6 | 4.7 | 1.7 | -2.2 | 1.9 | 1.8 | 1.6 | 2.0 | 2.0 | -2.0 | 1.9 |
| Delay disc. indifference point, 8s delay | 3.5 | 3.6 | 5.3 | -1.9 | 1.8 | -1.9 | -1.8 | -1.7 | -2.0 | -2.3 | 2.0 | -1.8 |
| Indifference point function ln k | 3.4 | 4.8 | 5.8 | -2.4 | 2.1 | -2.3 | -2.2 | -2.2 | -2.3 | -1.7 | 2.3 | -2.2 |
| Indifference point function log k | 3.4 | 4.8 | 5.8 | -2.4 | 2.1 | -2.3 | -2.2 | -2.2 | -2.3 | -1.7 | 2.3 | -2.2 |
| Locomotion velocity, session 3 | 3.4 | 3.9 | 5.0 | 1.9 | -2.2 | 2.1 | 2.1 | 2.2 | 1.8 | 1.1 | -2.0 | 2.1 |
| Total resting periods, locomotor time 2 | 3.2 | 3.4 | 4.2 | -1.9 | 1.9 | -1.9 | -2.0 | -2.1 | -2.0 | -0.8 | 1.8 | -2.0 |
| Progressive ratio test 1 breakpoint | 3.1 | 3.2 | 4.1 | 1.6 | -2.0 | 1.8 | 1.7 | 1.4 | 1.9 | 1.9 | -1.9 | 1.7 |
| Locomotion distance, session 1 | 3.0 | 3.8 | 5.1 | 1.9 | -2.3 | 2.1 | 2.1 | 2.2 | 1.9 | 0.7 | -1.9 | 2.1 |
| Delay discounting water rate 24 sec | 2.9 | 4.0 | 4.9 | -2.1 | 2.0 | -2.2 | -2.2 | -2.2 | -2.0 | -1.0 | 2.0 | -2.2 |
| Reaction time num false alarms AUC | 2.9 | 4.1 | 5.2 | 2.1 | -1.9 | 2.1 | 2.2 | 2.3 | 2.1 | 1.1 | -2.0 | 2.2 |
| Intermittent access total locomotion | 2.9 | 3.3 | 7.8 | 1.6 | -1.9 | 1.6 | 1.5 | 1.1 | 1.8 | 2.8 | -2.0 | 1.5 |
| Bouts of movement, locomotor time 2 | 2.9 | 3.2 | 4.0 | -1.8 | 1.8 | -1.9 | -1.9 | -2.0 | -2.0 | -0.8 | 1.7 | -1.9 |
| Right kidney weight | 2.8 | 8.0 | 9.2 | -2.8 | 3.0 | -2.9 | -2.9 | -2.7 | -3.0 | -2.2 | 3.0 | -2.9 |
| Delay discounting time to switch 0 sec | 2.8 | 4.2 | 5.2 | 2.2 | -1.9 | 2.1 | 2.0 | 1.9 | 2.3 | 1.8 | -2.1 | 2.0 |
| Light reinforcement 1 | 2.8 | 5.0 | 10.3 | 1.9 | -2.1 | 2.1 | 2.0 | 1.6 | 2.4 | 3.2 | -2.4 | 2.0 |
| Progressive ratio test 1 inactive lever presses | 2.7 | 2.9 | 3.9 | 1.5 | -2.0 | 1.7 | 1.7 | 1.4 | 1.6 | 1.9 | -1.8 | 1.7 |
| Reaction time premature initiations | 2.6 | 3.8 | 5.0 | 2.0 | -1.9 | 1.9 | 1.9 | 1.8 | 1.9 | 2.2 | -2.1 | 1.8 |
| Condit. Reinf. inactive responses | 2.6 | 3.1 | 3.4 | 1.8 | -1.7 | 1.8 | 1.7 | 1.6 | 1.8 | 1.7 | -1.8 | 1.7 |
| Weight adjusted by age | 2.6 | 3.0 | 4.2 | -1.8 | 1.6 | -1.8 | -1.9 | -2.0 | -1.7 | -0.6 | 1.7 | -1.9 |
| Progressive ratio test 2 inactive lever presses | 2.5 | 2.9 | 3.6 | 1.7 | -1.7 | 1.7 | 1.7 | 1.4 | 1.8 | 1.9 | -1.8 | 1.7 |
| Locomotor testing distance | 2.4 | 4.0 | 4.7 | 1.8 | -2.2 | 2.0 | 2.0 | 1.7 | 2.1 | 2.1 | -2.1 | 2.0 |
| Reaction time false alarm rate | 2.4 | 3.4 | 4.2 | 1.9 | -1.8 | 1.9 | 2.0 | 2.0 | 1.8 | 1.0 | -1.9 | 2.0 |
| Intermittent access terminal intake (last 3 days) | 2.4 | 2.7 | 3.5 | 1.6 | -1.9 | 1.7 | 1.7 | 1.6 | 1.8 | 1.0 | -1.6 | 1.7 |
| Locomotion distance, session 2 | 2.4 | 3.5 | 4.6 | 1.9 | -2.1 | 1.9 | 2.0 | 2.1 | 1.7 | 0.7 | -1.8 | 2.0 |
| Total heroin consumption | 2.4 | 2.9 | 4.3 | -1.9 | 1.5 | -1.8 | -1.8 | -2.1 | -1.9 | -0.4 | 1.5 | -1.8 |
| Intermittent access total infusions | 2.3 | 2.5 | 3.1 | 1.6 | -1.8 | 1.6 | 1.6 | 1.5 | 1.8 | 1.1 | -1.6 | 1.6 |
| Progressive ratio test 2 breakpoint | 2.3 | 2.6 | 4.0 | 1.5 | -1.7 | 1.5 | 1.5 | 1.2 | 1.7 | 2.0 | -1.7 | 1.5 |
| Bone: cortical porosity | 2.3 | 2.5 | 3.3 | 1.6 | -1.7 | 1.5 | 1.4 | 1.2 | 1.8 | 1.8 | -1.7 | 1.4 |
| Intermittent access day 15 total infusions | 2.2 | 2.4 | 3.1 | 1.5 | -1.7 | 1.6 | 1.6 | 1.5 | 1.8 | 1.0 | -1.6 | 1.6 |
| Delay discounting total patch changes 6 sec | 2.1 | 3.2 | 3.7 | 1.7 | -1.7 | 1.9 | 1.9 | 1.8 | 1.8 | 1.5 | -1.9 | 1.9 |
| Latency to leave start box in cocaine runway, M | 2.1 | 2.0 | 2.7 | -1.3 | 1.6 | -1.4 | -1.3 | -1.2 | -1.5 | -1.6 | 1.5 | -1.3 |
| Length with tail | 2.0 | 7.4 | 8.6 | -2.9 | 2.7 | -2.8 | -2.8 | -2.6 | -2.9 | -2.1 | 2.8 | -2.8 |
| Locomotor testing rearing | 2.0 | 3.2 | 5.2 | 1.5 | -1.7 | 1.8 | 1.7 | 1.3 | 2.0 | 2.3 | -2.0 | 1.7 |
| Total locomotion distance, NPP test | 2.0 | 2.8 | 3.5 | 1.6 | -1.9 | 1.8 | 1.7 | 1.7 | 1.9 | 0.7 | -1.6 | 1.8 |
| Liver weight, left | 1.9 | 3.2 | 3.6 | -1.8 | 1.9 | -1.8 | -1.8 | -1.7 | -1.7 | -1.5 | 1.8 | -1.8 |
| Tibialis anterior weight | 1.9 | 6.5 | 9.8 | -2.6 | 2.3 | -2.8 | -2.7 | -2.7 | -3.1 | -1.0 | 2.6 | -2.7 |
| Reaction time num false alarms | 1.9 | 2.7 | 3.1 | 1.7 | -1.6 | 1.7 | 1.7 | 1.8 | 1.6 | 1.2 | -1.7 | 1.7 |
| Liver weight, right | 1.8 | 3.0 | 3.7 | -1.9 | 1.5 | -1.8 | -1.8 | -1.8 | -1.8 | -1.4 | 1.8 | -1.8 |
| Pavlov. Cond. magazine entry number | 1.8 | 2.2 | 2.7 | 1.6 | -1.7 | 1.5 | 1.6 | 1.6 | 1.2 | 0.9 | -1.4 | 1.6 |
| Lifetime Intake | 1.8 | 2.0 | 2.6 | 1.4 | -1.6 | 1.4 | 1.4 | 1.3 | 1.6 | 0.9 | -1.4 | 1.4 |
| Bone: cortical porosity | 1.8 | 1.9 | 2.8 | 1.4 | -1.4 | 1.3 | 1.2 | 1.0 | 1.7 | 1.6 | -1.5 | 1.3 |
| Bone: trabecular spacing | 1.8 | 2.4 | 6.3 | 1.6 | -1.8 | 1.3 | 1.2 | 0.9 | 1.1 | 2.5 | -1.6 | 1.2 |
| Latency to leave start box in cocaine runway, F | 1.8 | 2.0 | 3.1 | 1.4 | -1.4 | 1.4 | 1.3 | 1.1 | 1.4 | 1.8 | -1.5 | 1.3 |
| Progressive ratio test 2 active lever presses | 1.7 | 1.8 | 3.0 | 1.2 | -1.4 | 1.3 | 1.2 | 1.0 | 1.4 | 1.7 | -1.5 | 1.2 |
| Novel to familiar place preference ratio | 1.7 | 1.8 | 2.6 | -1.6 | 1.5 | -1.4 | -1.5 | -1.6 | -1.0 | -0.2 | 1.2 | -1.4 |
| Indifference point 0 sec | 1.6 | 2.6 | 3.1 | 1.4 | -1.8 | 1.7 | 1.7 | 1.6 | 1.5 | 1.4 | -1.7 | 1.7 |
| Delay discounting total patch changes 0 sec | 1.6 | 2.6 | 2.9 | 1.4 | -1.7 | 1.7 | 1.7 | 1.6 | 1.5 | 1.5 | -1.7 | 1.7 |
| Delay disc. indifference point, 24s delay | 1.6 | 1.6 | 2.1 | -1.4 | 1.3 | -1.3 | -1.3 | -1.3 | -1.3 | -0.9 | 1.3 | -1.3 |
| Conditioned reinforcement - actives | 1.5 | 1.4 | 1.7 | 1.2 | -1.1 | 1.2 | 1.2 | 1.1 | 1.3 | 1.1 | -1.3 | 1.2 |
| Area under the delay curve | 1.5 | 1.6 | 2.7 | -1.2 | 1.1 | -1.2 | -1.1 | -1.1 | -1.3 | -1.6 | 1.3 | -1.1 |
| Delay disc. indifference point, 16s delay | 1.5 | 1.5 | 1.9 | -1.4 | 1.1 | -1.3 | -1.2 | -1.3 | -1.3 | -0.9 | 1.3 | -1.2 |
| Parametrial fat weight | 1.4 | 2.8 | 3.5 | 1.8 | -1.9 | 1.7 | 1.9 | 1.8 | 1.4 | 0.7 | -1.6 | 1.8 |
| Food consumed during 24 hour testing period | 1.4 | 1.7 | 4.0 | -1.3 | 1.4 | -1.2 | -1.1 | -0.7 | -1.2 | -2.0 | 1.4 | -1.1 |
| Delay discounting total patch changes 12 sec | 1.4 | 1.9 | 3.0 | 1.3 | -1.3 | 1.4 | 1.3 | 1.2 | 1.2 | 1.7 | -1.5 | 1.3 |
| Delay discounting total patch changes 24 sec | 1.4 | 1.8 | 4.9 | 1.1 | -1.4 | 1.2 | 1.2 | 0.9 | 1.2 | 2.2 | -1.5 | 1.2 |
| Ambulatory time after self-admin | 1.4 | 1.6 | 1.8 | 1.3 | -1.2 | 1.2 | 1.2 | 1.1 | 1.3 | 1.3 | -1.4 | 1.2 |
| Delay disc. indifference point, 0s delay | 1.4 | 1.6 | 2.2 | -1.1 | 1.2 | -1.3 | -1.3 | -1.5 | -1.4 | -0.7 | 1.3 | -1.3 |
| Fecal boli incidents, locomotor time 1 | 1.4 | 1.6 | 2.4 | 1.0 | -1.5 | 1.2 | 1.4 | 1.5 | 0.8 | -1.2 | -0.8 | 1.4 |
| Pavlov. Cond. change in total contacts | 1.3 | 1.9 | 2.6 | -1.4 | 1.6 | -1.3 | -1.4 | -1.2 | -1.0 | -1.6 | 1.4 | -1.3 |
| Conditioned reinforcement - inactives | 1.3 | 1.5 | 2.1 | 1.3 | -1.4 | 1.3 | 1.3 | 1.2 | 1.2 | 0.6 | -1.2 | 1.3 |
| Stereotopy head waving duration, day 7 | 1.3 | 1.6 | 2.1 | -1.1 | 1.4 | -1.4 | -1.4 | -1.5 | -1.4 | -0.0 | 1.2 | -1.4 |
| Time in closed arm before self-admin | 1.3 | 1.5 | 2.1 | -1.3 | 1.5 | -1.3 | -1.3 | -1.4 | -1.0 | 0.1 | 1.1 | -1.4 |
| Delay discount exponential model param | 1.3 | 1.4 | 2.5 | 1.1 | -1.1 | 1.1 | 1.0 | 1.0 | 1.2 | 1.6 | -1.2 | 1.0 |
| Run reversals in cocaine runway, males | 1.3 | 1.2 | 1.5 | 1.1 | -1.2 | 1.1 | 1.1 | 1.1 | 1.0 | 1.1 | -1.2 | 1.1 |
| Intermittent access day 1 total infusions | 1.2 | 1.4 | 1.7 | 1.2 | -1.3 | 1.2 | 1.2 | 1.2 | 1.3 | 0.7 | -1.2 | 1.2 |
| Baseline Anxiety | 1.2 | 1.2 | 1.5 | -1.1 | 0.9 | -1.1 | -1.1 | -1.1 | -1.1 | -1.2 | 1.2 | -1.1 |
| Novelty place preference | 1.2 | 1.2 | 2.1 | -1.4 | 1.3 | -1.1 | -1.2 | -1.4 | -0.7 | 0.1 | 0.9 | -1.2 |
| Diff in mean of infusions in LGA sessions | 1.2 | 1.4 | 2.1 | -1.1 | 1.3 | -1.1 | -1.1 | -0.9 | -1.2 | -1.4 | 1.2 | -1.1 |
| Time to tail flick, vehicle, before self-admin | 1.2 | 1.2 | 1.6 | 1.0 | -1.0 | 1.2 | 1.2 | 1.3 | 1.0 | 0.6 | -1.1 | 1.2 |
| Delay discount hyperbolic model param | 1.2 | 1.3 | 2.3 | 1.0 | -1.1 | 1.1 | 1.0 | 1.0 | 1.2 | 1.5 | -1.2 | 1.0 |
| Vertical activity count, locomotor time 1 | 1.2 | 1.2 | 2.6 | -1.0 | 1.1 | -1.1 | -1.0 | -0.8 | -1.0 | -1.6 | 1.2 | -1.0 |
| Intermittent access intake escalation 2 | 1.1 | 1.1 | 1.4 | 1.1 | -1.1 | 1.1 | 1.1 | 1.2 | 1.1 | 0.2 | -1.0 | 1.1 |
| Intermitt. access day 15 inactive lever presses | 1.1 | 1.2 | 1.7 | 1.0 | -1.2 | 1.0 | 1.0 | 0.8 | 1.0 | 1.3 | -1.2 | 1.0 |
| Intermittent access day 1 locomotion | 1.1 | 1.1 | 2.8 | 0.9 | -1.1 | 0.9 | 0.8 | 0.5 | 1.1 | 1.7 | -1.1 | 0.8 |
| Intermittent access day 15 total locomotion | 1.1 | 1.2 | 3.5 | 0.8 | -1.2 | 0.9 | 0.9 | 0.5 | 1.1 | 1.9 | -1.2 | 0.9 |
| Locomotion distance, session 7 | 1.1 | 1.4 | 2.2 | 1.2 | -1.5 | 1.2 | 1.2 | 1.0 | 1.2 | 1.2 | -1.2 | 1.2 |
| Locomotion distance, session 8 | 1.1 | 1.7 | 2.5 | 1.2 | -1.4 | 1.4 | 1.4 | 1.6 | 1.1 | 0.4 | -1.2 | 1.4 |
| Total zone transitions, NPP test | 1.1 | 1.5 | 2.5 | 1.2 | -1.6 | 1.3 | 1.3 | 1.5 | 1.2 | 0.1 | -1.1 | 1.3 |
| Locomotion velocity, NPP test | 1.1 | 1.5 | 2.0 | 1.2 | -1.4 | 1.3 | 1.3 | 1.4 | 1.4 | 0.1 | -1.1 | 1.3 |
| Distance traveled before self-admin | 1.1 | 1.1 | 2.4 | 1.1 | -1.0 | 1.0 | 0.9 | 0.8 | 1.0 | 1.6 | -1.1 | 0.9 |
| Cu content in liver | 1.1 | 1.4 | 1.8 | -1.3 | 0.5 | -1.2 | -1.2 | -1.1 | -1.3 | -1.2 | 1.3 | -1.2 |
| Intermittent access intake day 1-15 change | 1.0 | 1.0 | 1.3 | 1.1 | -1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 0.2 | -1.0 | 1.1 |
| Cocaine induced anxiety | 1.0 | 1.2 | 1.4 | -1.2 | 1.0 | -1.2 | -1.2 | -1.2 | -1.1 | -0.5 | 1.1 | -1.2 |
| Stereotopy head waving bouts, day 7 | 1.0 | 1.1 | 1.7 | -0.9 | 1.2 | -1.1 | -1.2 | -1.3 | -1.1 | 0.1 | 0.9 | -1.2 |
| Time in novel zone, NPP test | 1.0 | 1.0 | 1.9 | -1.2 | 1.2 | -1.0 | -1.1 | -1.4 | -0.6 | 0.3 | 0.7 | -1.1 |
| Time in open arm before self-admin | 1.0 | 1.0 | 1.4 | -1.2 | 0.7 | -1.0 | -1.0 | -1.2 | -1.2 | -0.8 | 1.0 | -1.0 |
| Delay disc. indifference point, 2s delay | 1.0 | 1.1 | 1.3 | -0.9 | 1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -0.8 | 1.1 | -1.1 |
| Std. dev. time between licks in bursts | 0.9 | 1.1 | 1.6 | 1.0 | -1.0 | 1.0 | 0.9 | 0.7 | 1.2 | 1.3 | -1.1 | 0.9 |
| Cocaine response after cond. not corrected | 0.9 | 1.0 | 1.8 | 1.0 | -0.9 | 1.0 | 1.1 | 1.3 | 0.8 | -0.6 | -0.7 | 1.1 |
| Condit. Reinf. inactive responses | 0.9 | 1.1 | 2.3 | 1.0 | -0.8 | 1.0 | 0.9 | 0.7 | 1.1 | 1.5 | -1.1 | 0.9 |
| Short access day 1 total inactive lever presses | 0.9 | 1.0 | 1.2 | 1.1 | -1.1 | 1.0 | 1.0 | 0.8 | 1.0 | 0.9 | -1.0 | 1.0 |
| Locomotion velocity, session 1 | 0.9 | 1.0 | 1.8 | 1.0 | -1.4 | 0.9 | 0.9 | 0.8 | 0.7 | 1.3 | -1.0 | 0.9 |
| Stereotopy head waving bouts, day 3 | 0.9 | 1.1 | 1.7 | -0.9 | 1.1 | -1.1 | -1.2 | -1.3 | -1.0 | -0.3 | 1.0 | -1.2 |
| Change in fecal boli incidents, locomotor task | 0.9 | 0.8 | 1.1 | -0.9 | 0.9 | -1.0 | -1.0 | -1.0 | -0.9 | -0.4 | 0.9 | -1.0 |
| K content in liver | 0.9 | 0.9 | 1.6 | -0.9 | 0.7 | -0.9 | -0.8 | -0.7 | -1.3 | -1.2 | 1.0 | -0.8 |
| Locomotor activity | 0.8 | 1.3 | 1.9 | 1.0 | -1.3 | 1.1 | 1.0 | 0.9 | 1.1 | 1.4 | -1.2 | 1.0 |
| Reaction time trials AUC | 0.8 | 1.1 | 1.4 | -1.1 | 1.1 | -1.1 | -1.2 | -1.1 | -0.9 | -0.7 | 1.1 | -1.2 |
| Degree of sensitization distance | 0.8 | 0.8 | 1.0 | -0.8 | 0.9 | -0.9 | -0.9 | -1.0 | -1.0 | -0.3 | 0.9 | -0.9 |
| Sr content in liver | 0.8 | 0.7 | 0.9 | -0.9 | 0.5 | -0.9 | -0.9 | -0.9 | -0.9 | -0.6 | 0.9 | -0.9 |
| Zn content in liver | 0.8 | 0.9 | 1.7 | 0.9 | -1.3 | 0.8 | 0.8 | 0.7 | 0.6 | 1.3 | -0.9 | 0.8 |
| Soleus weight | 0.7 | 2.1 | 3.4 | -1.4 | 1.3 | -1.6 | -1.5 | -1.4 | -1.8 | -0.6 | 1.5 | -1.5 |
| Light reinforcement 2 | 0.7 | 1.0 | 1.4 | 1.0 | -0.9 | 1.0 | 1.0 | 0.8 | 1.2 | 1.0 | -1.0 | 1.0 |
| Intermittent access intake escalation | 0.7 | 0.7 | 1.0 | 0.9 | -0.9 | 0.9 | 0.9 | 1.0 | 0.9 | -0.1 | -0.8 | 0.9 |
| Compulsive drug intake | 0.7 | 0.7 | 1.1 | -0.8 | 1.0 | -0.8 | -0.8 | -0.6 | -0.8 | -1.0 | 0.9 | -0.8 |
| Locomotion in novel chamber | 0.7 | 0.9 | 1.2 | -0.8 | 1.0 | -1.0 | -1.0 | -1.1 | -1.0 | -0.5 | 0.9 | -1.0 |
| Pavlov. Cond. magazine entry latency | 0.6 | 0.7 | 1.1 | -0.9 | 1.0 | -0.8 | -0.9 | -0.9 | -0.5 | -0.6 | 0.8 | -0.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.6 | 0.8 | 1.3 | -0.9 | 1.1 | -0.9 | -1.0 | -1.0 | -0.5 | -0.6 | 0.9 | -1.0 |
| Short access day 10 total inactive lever presses | 0.6 | 0.6 | 2.6 | 0.7 | -0.5 | 0.6 | 0.5 | 0.4 | 0.7 | 1.6 | -0.8 | 0.5 |
| Condit. Reinf. active responses | 0.6 | 0.7 | 1.0 | 0.9 | -0.9 | 0.9 | 0.9 | 1.0 | 0.8 | 0.1 | -0.8 | 0.9 |
| Left kidney weight | 0.5 | 1.3 | 5.6 | -0.7 | 0.9 | -0.9 | -0.7 | -0.3 | -1.1 | -2.4 | 1.3 | -0.8 |
| Delay discounting water rate 18 sec | 0.5 | 0.7 | 1.0 | -0.9 | 0.6 | -0.9 | -0.8 | -0.7 | -1.0 | -0.7 | 0.9 | -0.8 |
| Reaction time number correct | 0.5 | 0.8 | 1.0 | -0.9 | 1.0 | -0.9 | -1.0 | -0.9 | -0.7 | -0.5 | 0.9 | -1.0 |
| Reaction time trials correct on left | 0.5 | 0.8 | 1.0 | -0.9 | 1.0 | -0.9 | -1.0 | -0.9 | -0.7 | -0.5 | 0.9 | -1.0 |
| Reaction time mean | 0.5 | 0.7 | 1.2 | 0.9 | -0.6 | 0.9 | 0.9 | 0.9 | 1.1 | -0.1 | -0.8 | 0.9 |
| Condit. Reinf. lever reinforcers received | 0.5 | 0.7 | 1.0 | 0.8 | -0.8 | 0.9 | 0.9 | 0.8 | 0.8 | 1.0 | -1.0 | 0.9 |
| Intermittent access standard deviation | 0.5 | 0.5 | 0.8 | 0.9 | -0.7 | 0.8 | 0.7 | 0.9 | 0.9 | 0.1 | -0.7 | 0.8 |
| Short access day 10 total infusions | 0.5 | 0.6 | 0.8 | 0.7 | -0.9 | 0.8 | 0.8 | 0.9 | 0.9 | 0.1 | -0.7 | 0.8 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.6 | 0.9 | 0.9 | -0.9 | 0.8 | 0.8 | 0.8 | 0.7 | 0.2 | -0.7 | 0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.5 | 0.6 | 1.0 | -0.9 | 0.5 | -0.7 | -0.7 | -0.7 | -0.6 | -1.0 | 0.8 | -0.7 |
| Bone: cortical tissue density | 0.5 | 0.7 | 1.3 | 0.9 | -0.7 | 0.8 | 0.7 | 0.5 | 0.9 | 1.2 | -0.9 | 0.8 |
| Bone: tissue strength | 0.5 | 0.5 | 0.7 | -0.8 | 0.7 | -0.7 | -0.7 | -0.8 | -0.5 | -0.4 | 0.6 | -0.7 |
| Active lever presses in extinction session 6 | 0.5 | 0.5 | 1.0 | -0.7 | 0.6 | -0.6 | -0.6 | -0.4 | -0.8 | -1.0 | 0.7 | -0.6 |
| Time in closed arm after self-admin | 0.5 | 0.5 | 0.7 | -0.7 | 0.9 | -0.7 | -0.7 | -0.7 | -0.7 | -0.5 | 0.7 | -0.7 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 0.7 | 0.8 | -0.7 | 0.7 | 0.7 | 0.7 | 0.9 | 0.4 | -0.7 | 0.7 |
| Delay disc. indifference point, 4s delay | 0.5 | 0.6 | 2.3 | -0.6 | 0.7 | -0.5 | -0.4 | -0.3 | -0.7 | -1.5 | 0.7 | -0.4 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 1.6 | -0.6 | 0.3 | -0.6 | -0.5 | -0.6 | -0.7 | -1.3 | 0.8 | -0.5 |
| Epididymis fat weight | 0.4 | 0.9 | 1.6 | -1.0 | 0.5 | -0.9 | -0.7 | -0.8 | -1.3 | -1.3 | 1.0 | -0.7 |
| Mean num. licks in bursts | 0.4 | 0.5 | 2.8 | 0.2 | -0.4 | 0.2 | 0.4 | 0.9 | -0.2 | -1.7 | 0.2 | 0.4 |
| Reaction time trials on left | 0.4 | 0.5 | 0.7 | -0.7 | 0.8 | -0.8 | -0.8 | -0.7 | -0.6 | -0.4 | 0.8 | -0.8 |
| Reaction time trials completed | 0.4 | 0.5 | 0.7 | -0.7 | 0.8 | -0.8 | -0.8 | -0.7 | -0.6 | -0.4 | 0.8 | -0.8 |
| Pavlov. Cond. latency score | 0.4 | 0.5 | 0.8 | -0.8 | 0.9 | -0.7 | -0.8 | -0.7 | -0.4 | -0.7 | 0.7 | -0.7 |
| Conditioned locomotion | 0.4 | 0.4 | 1.4 | 0.6 | -0.6 | 0.6 | 0.5 | 0.3 | 0.7 | 1.2 | -0.7 | 0.5 |
| Short access day 10 total locomotion | 0.4 | 0.5 | 3.4 | 0.4 | -0.4 | 0.2 | 0.1 | -0.2 | 0.4 | 1.9 | -0.6 | 0.1 |
| Degree of sensitization stereotypy | 0.4 | 0.5 | 0.7 | -0.5 | 0.6 | -0.7 | -0.7 | -0.8 | -0.8 | 0.6 | 0.5 | -0.7 |
| Time in familiar zone, hab. session 1 | 0.4 | 0.4 | 0.8 | 0.7 | -0.8 | 0.6 | 0.7 | 0.9 | 0.4 | -0.2 | -0.4 | 0.7 |
| Time in novel zone, hab. session 1 | 0.4 | 0.4 | 1.0 | -0.7 | 0.8 | -0.6 | -0.7 | -1.0 | -0.2 | 0.6 | 0.3 | -0.7 |
| Time in novel zone, hab. session 2 | 0.4 | 0.4 | 2.5 | 0.5 | -0.5 | 0.2 | 0.2 | -0.1 | 0.1 | 1.6 | -0.5 | 0.1 |
| Bone: cortical apparent density | 0.4 | 0.5 | 1.1 | 0.7 | -0.6 | 0.7 | 0.6 | 0.4 | 0.8 | 1.0 | -0.8 | 0.6 |
| Extinction: sum of active levers before priming | 0.4 | 0.4 | 0.6 | -0.5 | 0.5 | -0.7 | -0.7 | -0.7 | -0.7 | -0.2 | 0.6 | -0.7 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.4 | 0.6 | -0.5 | 0.6 | -0.7 | -0.8 | -0.8 | -0.5 | -0.1 | 0.7 | -0.8 |
| Seeking ratio, delayed vs. immediate footshock | 0.4 | 0.5 | 2.9 | -0.2 | 0.6 | -0.5 | -0.4 | -0.1 | -0.4 | -1.7 | 0.7 | -0.4 |
| Se content in liver | 0.4 | 0.4 | 0.7 | 0.7 | -0.8 | 0.7 | 0.7 | 0.8 | 0.5 | 0.1 | -0.6 | 0.7 |
| Number of licking bursts | 0.3 | 0.3 | 2.0 | 0.1 | -0.2 | 0.2 | 0.1 | -0.2 | 0.5 | 1.4 | -0.5 | 0.1 |
| Mean time between licks in bursts | 0.3 | 0.5 | 0.8 | 0.8 | -0.9 | 0.7 | 0.6 | 0.5 | 0.9 | 0.5 | -0.7 | 0.6 |
| Reaction time mean AUC | 0.3 | 0.4 | 0.7 | 0.7 | -0.4 | 0.7 | 0.7 | 0.7 | 0.9 | -0.4 | -0.6 | 0.7 |
| Cocaine response after cond. corrected | 0.3 | 0.4 | 2.6 | 0.1 | -0.1 | 0.1 | 0.3 | 0.6 | -0.3 | -1.6 | 0.3 | 0.2 |
| Pavlov. Cond. index score | 0.3 | 0.4 | 0.8 | -0.7 | 0.9 | -0.6 | -0.7 | -0.7 | -0.3 | -0.6 | 0.6 | -0.7 |
| Intermitt. access escalation Index | 0.3 | 0.3 | 0.6 | 0.4 | -0.6 | 0.5 | 0.4 | 0.3 | 0.5 | 0.8 | -0.5 | 0.4 |
| Total sessions with >9 infusions | 0.3 | 0.3 | 0.5 | 0.6 | -0.6 | 0.6 | 0.6 | 0.4 | 0.7 | 0.3 | -0.6 | 0.6 |
| Short access total locomotion | 0.3 | 0.3 | 2.1 | 0.3 | -0.5 | 0.3 | 0.2 | -0.1 | 0.5 | 1.4 | -0.5 | 0.2 |
| Number of responses in last shaping day | 0.3 | 0.4 | 0.7 | -0.7 | 0.3 | -0.6 | -0.6 | -0.9 | -0.6 | 0.2 | 0.5 | -0.6 |
| Context. condit. distance diff. score | 0.3 | 0.4 | 0.6 | -0.8 | 0.6 | -0.7 | -0.7 | -0.7 | -0.7 | -0.2 | 0.7 | -0.7 |
| Locomotion velocity, session 2 | 0.3 | 0.4 | 0.7 | 0.4 | -0.9 | 0.6 | 0.7 | 0.7 | 0.5 | 0.2 | -0.5 | 0.6 |
| Stereotopy head waving duration, day 3 | 0.3 | 0.4 | 0.6 | -0.5 | 0.7 | -0.6 | -0.7 | -0.8 | -0.5 | -0.1 | 0.6 | -0.7 |
| Condit. Reinf. lever presses | 0.3 | 0.4 | 0.7 | -0.7 | 0.4 | -0.6 | -0.6 | -0.6 | -0.4 | -0.8 | 0.7 | -0.6 |
| Total zone transitions, hab. session 1 | 0.3 | 0.4 | 0.6 | 0.4 | -0.8 | 0.6 | 0.6 | 0.5 | 0.6 | 0.7 | -0.7 | 0.6 |
| Bone: cortical thickness | 0.3 | 0.4 | 0.7 | -0.7 | 0.7 | -0.6 | -0.5 | -0.4 | -0.5 | -0.9 | 0.7 | -0.5 |
| Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 2.0 | -0.3 | 0.4 | -0.3 | -0.2 | 0.0 | -0.4 | -1.4 | 0.5 | -0.2 |
| Delta time to tail flick, test, before/after SA | 0.3 | 0.3 | 0.5 | -0.6 | 0.5 | -0.6 | -0.5 | -0.5 | -0.7 | -0.2 | 0.5 | -0.5 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.3 | 0.8 | 0.6 | -0.9 | 0.5 | 0.6 | 0.5 | 0.4 | 0.3 | -0.5 | 0.6 |
| Distance moved, locomotor task time 2 | 0.3 | 0.4 | 0.6 | 0.7 | -0.6 | 0.6 | 0.5 | 0.5 | 0.7 | 0.7 | -0.6 | 0.5 |
| Locomotion in novel chamber post-restriction | 0.3 | 0.3 | 0.6 | -0.5 | 0.1 | -0.6 | -0.5 | -0.8 | -0.8 | -0.3 | 0.5 | -0.5 |
| Cd content in liver | 0.3 | 0.3 | 0.7 | 0.6 | -0.8 | 0.6 | 0.6 | 0.6 | 0.5 | 0.4 | -0.6 | 0.6 |
| Glucose | 0.2 | 0.2 | 0.5 | -0.5 | 0.5 | -0.5 | -0.6 | -0.7 | -0.3 | -0.0 | 0.4 | -0.5 |
| Retroperitoneal fat weight | 0.2 | 0.8 | 1.7 | 0.9 | -1.3 | 0.8 | 1.0 | 1.2 | 0.4 | -0.6 | -0.5 | 0.9 |
| Indifference point AUC | 0.2 | 0.2 | 1.0 | 0.5 | -0.2 | 0.4 | 0.4 | 0.3 | 0.3 | 1.0 | -0.5 | 0.4 |
| Social response proportion | 0.2 | 0.2 | 0.5 | 0.6 | -0.2 | 0.5 | 0.4 | 0.7 | 0.7 | 0.1 | -0.4 | 0.5 |
| Social time | 0.2 | 0.3 | 0.7 | 0.4 | -0.1 | 0.6 | 0.5 | 0.8 | 0.8 | -0.6 | -0.3 | 0.5 |
| Conditioned locomotion | 0.2 | 0.2 | 1.1 | 0.1 | 0.1 | -0.2 | -0.3 | -0.6 | 0.1 | 1.1 | -0.1 | -0.3 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 0.3 | 0.4 | -0.5 | 0.5 | 0.6 | 0.5 | 0.3 | 0.3 | -0.5 | 0.5 |
| Condit. Reinf. active responses | 0.2 | 0.3 | 0.7 | 0.4 | -0.4 | 0.5 | 0.5 | 0.4 | 0.5 | 0.8 | -0.7 | 0.5 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 1.2 | -0.3 | 0.3 | -0.3 | -0.2 | 0.0 | -0.3 | -1.1 | 0.5 | -0.2 |
| Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 1.0 | -0.5 | 0.5 | -0.2 | -0.2 | -0.1 | -0.1 | -1.0 | 0.4 | -0.2 |
| Total zone transitions, hab. session 2 | 0.2 | 0.3 | 0.7 | 0.3 | -0.8 | 0.5 | 0.6 | 0.7 | 0.2 | -0.3 | -0.3 | 0.6 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.4 | -0.7 | 0.5 | 0.5 | 0.6 | 0.4 | -0.3 | -0.3 | 0.5 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.5 | 0.3 | -0.6 | 0.5 | 0.4 | 0.4 | 0.7 | -0.0 | -0.4 | 0.4 |
| Bone: trabecular thickness | 0.2 | 0.2 | 0.5 | 0.1 | -0.3 | 0.5 | 0.5 | 0.6 | 0.7 | -0.6 | -0.3 | 0.5 |
| Breakpoint value in progressive ratio session | 0.2 | 0.2 | 0.4 | -0.4 | 0.6 | -0.4 | -0.4 | -0.4 | -0.6 | -0.5 | 0.4 | -0.4 |
| Delta distance traveled before/after self-admin | 0.2 | 0.2 | 1.5 | -0.2 | 0.2 | -0.2 | -0.1 | 0.1 | -0.3 | -1.2 | 0.4 | -0.1 |
| Time in open arm after self-admin | 0.2 | 0.2 | 0.4 | 0.5 | -0.6 | 0.4 | 0.4 | 0.4 | 0.5 | 0.6 | -0.5 | 0.4 |
| Time to tail flick, vehicle, after self-admin | 0.2 | 0.2 | 0.5 | -0.4 | 0.4 | -0.4 | -0.5 | -0.7 | -0.2 | 0.7 | 0.2 | -0.5 |
| Rest time, locomotor task time 2 | 0.2 | 0.2 | 0.5 | -0.5 | 0.2 | -0.4 | -0.4 | -0.4 | -0.4 | -0.7 | 0.5 | -0.3 |
| BMI without tail | 0.1 | 0.2 | 0.5 | -0.5 | 0.5 | -0.4 | -0.4 | -0.5 | -0.4 | -0.7 | 0.5 | -0.4 |
| Times rat made contact with spout | 0.1 | 0.1 | 0.6 | -0.2 | -0.2 | -0.0 | 0.1 | 0.4 | -0.3 | -0.8 | 0.2 | 0.1 |
| Water consumed over 24 hours | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | -0.1 | -0.0 | 0.1 | -0.4 | -0.5 | 0.2 | -0.0 |
| Median of all reaction times | 0.1 | 0.1 | 0.3 | -0.2 | 0.4 | -0.2 | -0.2 | -0.2 | 0.2 | -0.5 | 0.2 | -0.2 |
| Pavlov. Cond. lever contacts | 0.1 | 0.2 | 0.5 | 0.4 | -0.2 | 0.4 | 0.4 | 0.3 | 0.7 | 0.1 | -0.4 | 0.4 |
| Incentive Sensitization - Responses | 0.1 | 0.1 | 0.1 | -0.2 | 0.4 | -0.3 | -0.3 | -0.2 | -0.3 | 0.0 | 0.2 | -0.3 |
| Short access total infusions | 0.1 | 0.1 | 0.3 | 0.3 | -0.5 | 0.4 | 0.4 | 0.3 | 0.5 | 0.2 | -0.3 | 0.4 |
| Short access day 1 locomotion | 0.1 | 0.1 | 0.3 | -0.2 | -0.1 | -0.2 | -0.2 | -0.5 | -0.1 | 0.5 | 0.0 | -0.1 |
| One hour access (0.3 mA shock) | 0.1 | 0.2 | 0.3 | 0.3 | -0.5 | 0.4 | 0.4 | 0.5 | 0.5 | 0.0 | -0.4 | 0.4 |
| Locomotion velocity, session 7 | 0.1 | 0.1 | 0.3 | 0.2 | -0.5 | 0.2 | 0.2 | 0.1 | 0.1 | 0.4 | -0.2 | 0.2 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.2 | 0.3 | 0.3 | -0.4 | 0.4 | 0.4 | 0.6 | 0.3 | -0.5 | -0.2 | 0.4 |
| Incentive salience index mean | 0.1 | 0.1 | 0.5 | -0.3 | 0.1 | -0.2 | -0.2 | -0.1 | -0.1 | -0.7 | 0.3 | -0.2 |
| Locomotion velocity, hab. session 2 | 0.1 | 0.1 | 0.4 | 0.2 | -0.5 | 0.3 | 0.3 | 0.5 | 0.2 | -0.6 | -0.1 | 0.3 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.6 | -0.1 | -0.1 | 0.1 | 0.2 | 0.3 | 0.1 | -0.7 | 0.0 | 0.2 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.2 | -0.3 | 0.0 | -0.2 | -0.3 | -0.2 | 0.0 | -0.5 | 0.3 | -0.2 |
| Pavlov. Cond. index score | 0.1 | 0.2 | 0.4 | -0.5 | 0.2 | -0.4 | -0.4 | -0.4 | -0.2 | -0.6 | 0.5 | -0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.4 | -0.5 | 0.2 | -0.3 | -0.4 | -0.3 | -0.1 | -0.7 | 0.4 | -0.3 |
| Pavlov. Cond. response bias | 0.1 | 0.1 | 0.4 | 0.1 | -0.3 | 0.2 | 0.2 | 0.4 | 0.3 | -0.6 | -0.1 | 0.3 |
| Bone: elastic work | 0.1 | 0.1 | 0.2 | 0.1 | -0.3 | 0.2 | 0.2 | 0.1 | 0.4 | 0.4 | -0.3 | 0.2 |
| Bone: trabecular tissue density | 0.1 | 0.2 | 0.9 | 0.1 | -0.4 | 0.3 | 0.2 | -0.0 | 0.4 | 1.0 | -0.5 | 0.2 |
| Distance traveled after self-admin | 0.1 | 0.2 | 0.3 | 0.4 | -0.4 | 0.4 | 0.4 | 0.5 | 0.3 | -0.1 | -0.4 | 0.4 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.1 | 0.6 | -0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.2 | -0.8 | 0.2 | -0.1 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.2 | 0.5 | -0.3 | 0.4 | 0.4 | 0.3 | 0.4 | 0.2 | -0.4 | 0.4 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | -0.4 | -0.3 | -0.4 | -0.4 | -0.3 | 0.4 | -0.3 |
| Bouts of movement, locomotor time 1 | 0.1 | 0.2 | 0.6 | -0.3 | -0.1 | -0.3 | -0.2 | -0.2 | -0.5 | -0.8 | 0.4 | -0.2 |
| Total resting periods, locomotor time 1 | 0.1 | 0.1 | 0.3 | 0.2 | -0.6 | 0.3 | 0.3 | 0.3 | 0.1 | -0.4 | -0.1 | 0.4 |
| Rest time, locomotor task time 1 | 0.1 | 0.2 | 0.4 | 0.5 | -0.6 | 0.4 | 0.4 | 0.4 | 0.2 | -0.3 | -0.2 | 0.4 |
| Distance moved, locomotor task time 1 | 0.1 | 0.1 | 0.4 | 0.3 | 0.1 | 0.3 | 0.2 | 0.2 | 0.6 | 0.6 | -0.3 | 0.2 |
| Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | -0.4 | -0.3 | -0.4 | -0.5 | -0.1 | 0.3 | -0.3 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.7 | -0.1 | -0.8 | 0.2 | 0.3 | 0.2 | 0.0 | 0.0 | -0.2 | 0.3 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.3 | 0.3 | 0.1 | 0.3 | 0.2 | 0.2 | 0.4 | 0.6 | -0.3 | 0.2 |
| Co content in liver | 0.1 | 0.1 | 0.3 | 0.1 | -0.3 | 0.3 | 0.2 | 0.1 | 0.6 | 0.2 | -0.3 | 0.2 |
| Fe content in liver | 0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.1 | -0.3 | 0.3 |
| Mn content in liver | 0.1 | 0.1 | 0.3 | -0.3 | 0.1 | -0.2 | -0.2 | -0.3 | -0.5 | 0.4 | 0.2 | -0.2 |
| Heart weight | 0.0 | 0.1 | 0.3 | 0.2 | 0.0 | 0.0 | 0.0 | 0.3 | 0.0 | -0.6 | 0.1 | 0.0 |
| Tail length | 0.0 | 0.1 | 0.4 | 0.1 | -0.2 | 0.2 | 0.2 | 0.1 | 0.3 | 0.6 | -0.3 | 0.3 |
| Saline control response | 0.0 | 0.0 | 0.2 | -0.1 | 0.4 | 0.1 | -0.0 | -0.0 | 0.4 | -0.0 | -0.1 | -0.0 |
| Condit. Reinf. active minus inactive responses | 0.0 | 0.0 | 0.2 | 0.0 | -0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.5 | -0.2 | 0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.1 | -0.1 | 0.1 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.1 | -0.0 | -0.0 | -0.3 | -0.0 | 0.1 | -0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.0 | 0.2 | 0.2 | 0.1 | 0.2 | 0.1 | 0.1 | 0.5 | 0.1 | -0.2 | 0.1 |
| Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.1 | -0.0 | 0.2 | -0.1 | -0.2 | -0.1 | -0.1 | 0.2 | 0.1 | -0.2 |
| Short access day 1 total infusions | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.2 | -0.1 | -0.3 | -0.2 | -0.4 | 0.2 | -0.1 |
| One hour access (shock baseline) | 0.0 | 0.0 | 0.2 | 0.0 | -0.4 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 |
| Locomotion velocity, session 8 | 0.0 | 0.0 | 0.2 | -0.2 | 0.0 | -0.2 | -0.1 | -0.1 | -0.5 | -0.1 | 0.2 | -0.2 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | 0.2 | 0.2 | 0.3 | -0.2 | -0.1 | 0.2 |
| Locomotion velocity, hab. session 1 | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.1 | 0.1 | 0.1 | 0.2 | -0.1 | -0.0 | 0.1 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | 0.0 | 0.1 | 0.0 | -0.2 | 0.4 | -0.1 | 0.0 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | -0.1 | -0.1 | -0.2 | -0.1 | 0.4 | -0.0 | -0.1 |
| Progressive ratio | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | 0.1 | 0.2 | 0.2 | -0.0 | -0.3 | -0.0 | 0.2 |
| Seeking ratio, punishment vs. effort | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.1 | -0.1 | -0.2 | -0.0 | 0.3 | 0.0 | -0.1 |
| Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | 0.1 | -0.0 | 0.1 | 0.2 | -0.1 | 0.1 |
| Mg content in liver | 0.0 | 0.0 | 0.2 | 0.1 | 0.3 | -0.1 | -0.0 | -0.1 | -0.2 | -0.4 | 0.2 | -0.0 |
| Na content in liver | 0.0 | 0.0 | 0.2 | 0.1 | -0.0 | -0.2 | -0.1 | -0.1 | -0.5 | 0.3 | 0.1 | -0.2 |
| Rb content in liver | 0.0 | 0.1 | 0.2 | 0.2 | -0.3 | 0.2 | 0.2 | 0.0 | 0.1 | 0.4 | -0.2 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.