Hub : Genes

Ormdl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability ENSRNOG00000030120 0.06 0.05 3.1e-03 0.04 0.05 0.04 0.04 2.2e-03 1.5e-03 2.2e-03 2.4e-03
2 Liver gene expression ENSRNOG00000030120 0.08 0.06 1.9e-06 0.01 0.04 0.04 0.03 1.9e-02 1.9e-05 3.4e-05 1.6e-04
3 PL mRNA stability ENSRNOG00000030120 0.06 0.04 1.1e-03 0.03 0.02 0.02 0.02 2.9e-03 6.2e-03 2.1e-02 6.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail6.119.825.75.0-2.95.1
BMI without tail1.12.23.82.0-0.51.6
Body weight1.25.17.02.5-1.32.7
Epididymis fat weight0.10.10.3-0.20.6-0.3
Glucose1.72.53.41.8-0.91.8
Heart weight0.10.10.20.10.5-0.2
Left kidney weight0.41.22.7-0.1-1.60.9
Right kidney weight0.20.61.3-1.1-0.3-0.7
Tail length4.012.015.6-3.43.0-4.0
Length with tail1.13.95.5-2.41.2-2.1
Length without tail0.40.81.60.1-1.30.9
Liver weight, left0.91.52.71.7-0.41.3
Liver weight, right0.71.11.31.1-0.91.2
Parametrial fat weight0.10.20.3-0.20.6-0.5
Retroperitoneal fat weight1.75.79.23.0-1.12.6
Intraocular pressure0.81.12.6-0.11.6-0.8
Extensor digitorum longus weight4.016.026.45.1-1.54.4
Soleus weight5.516.021.24.5-2.54.6
Tibialis anterior weight1.24.05.52.2-1.42.3
Tibia length0.72.12.5-1.51.3-1.6
Number of licking bursts2.53.05.42.3-0.31.9
Food consumed during 24 hour testing period0.40.40.50.7-0.50.7
Times rat made contact with spout0.80.91.81.3-0.00.9
Mean time between licks in bursts1.11.52.0-1.01.2-1.4
Mean num. licks in bursts0.60.71.2-1.10.2-0.9
Std. dev. time between licks in bursts0.70.81.5-1.2-0.6-0.6
Water consumed over 24 hours1.21.42.60.5-1.61.1
Indifference point 0 sec2.74.45.42.2-1.72.3
Indifference point AUC0.30.40.5-0.70.5-0.6
Indifference point function ln k0.00.00.10.4-0.10.1
Indifference point function log k0.00.00.10.4-0.10.1
Delay discounting total patch changes 0 sec2.43.94.72.2-1.52.2
Delay discounting total patch changes 12 sec1.21.62.91.7-0.31.3
Delay discounting total patch changes 18 sec0.00.10.10.2-0.10.3
Delay discounting total patch changes 24 sec0.70.91.30.8-0.91.1
Delay discounting total patch changes 6 sec1.32.02.51.6-1.11.6
Delay discounting time to switch 0 sec0.50.81.30.3-1.21.0
Delay discounting water rate 0 sec0.40.61.31.10.60.4
Delay discounting water rate 12 sec0.50.81.91.40.50.5
Delay discounting water rate 18 sec1.41.94.50.72.1-0.9
Delay discounting water rate 24 sec1.82.54.42.11.70.5
Delay discounting water rate 6 sec1.62.34.3-0.32.1-1.6
Locomotor activity2.13.36.1-2.50.3-1.9
Locomotor testing distance0.81.42.6-1.60.2-1.2
Locomotor testing rearing0.00.10.10.20.4-0.1
Light reinforcement 13.15.77.9-2.71.4-2.8
Light reinforcement 21.01.32.0-1.20.7-1.4
Reaction time number correct0.81.12.41.50.31.0
Reaction time mean minus median1.01.32.0-1.40.5-1.2
Reaction time mean minus median AUC1.11.43.1-1.8-0.7-0.7
Reaction time num false alarms0.40.51.01.0-0.20.7
Reaction time num false alarms AUC0.40.61.41.20.00.7
Reaction time trials correct on left0.81.12.41.50.31.0
Reaction time trials on left0.81.12.21.50.21.0
Reaction time mean0.71.02.3-1.5-0.3-0.7
Reaction time mean AUC0.40.51.2-1.1-0.5-0.3
Median of all reaction times0.40.51.2-1.1-0.5-0.3
Reaction time omissions0.00.10.1-0.3-0.4-0.0
Reaction time false alarm rate0.10.10.20.3-0.40.3
Reaction time premature initiation rate1.72.33.2-0.91.8-1.7
Reaction time premature initiations1.31.84.0-0.12.0-1.2
Std. dev. reaction times0.60.81.7-1.3-0.1-0.8
Reaction time trials completed0.81.12.21.50.21.0
Reaction time trials AUC0.91.32.61.60.41.0
Social response proportion0.30.40.9-1.0-0.1-0.4
Social responses5.87.513.0-3.61.0-2.9
Social time1.11.42.11.4-0.51.4
Conditioned locomotion1.01.22.41.60.60.9
Cocaine response after cond. corrected1.61.83.81.90.31.3
Cocaine response after cond. not corrected1.61.83.92.00.51.1
Cocaine response before conditioning0.50.60.9-0.90.2-0.9
Saline control response0.30.40.70.9-0.10.6
Condit. Reinf. active minus inactive responses2.73.34.6-1.41.9-2.2
Condit. Reinf. active-inactive response ratio1.61.73.5-0.21.9-1.2
Condit. Reinf. active responses1.72.33.6-1.51.1-1.9
Condit. Reinf. inactive responses0.40.50.9-0.9-0.2-0.7
Condit. Reinf. lever presses3.04.15.8-1.81.8-2.4
Condit. Reinf. lever reinforcers received1.41.92.9-1.21.2-1.7
Pavlov. Cond. lever latency1.21.62.21.5-0.81.5
Pavlov. Cond. magazine entry latency1.92.23.2-1.80.8-1.7
Pavlov. Cond. change in total contacts0.81.11.6-1.10.7-1.3
Pavlov. Cond. index score1.92.43.3-1.71.0-1.8
Pavlov. Cond. latency score1.72.23.1-1.80.8-1.7
Pavlov. Cond. lever contacts1.21.72.3-1.31.1-1.5
Pavlov. Cond. magazine entry number1.82.23.21.8-0.71.7
Pavlov. Cond. intertrial magazine entries0.60.81.71.30.10.8
Pavlov. Cond. lever-magazine prob. diff.1.92.53.4-1.80.9-1.8
Pavlov. Cond. response bias2.12.93.9-1.71.4-2.0
Conditioned reinforcement - actives0.30.30.4-0.7-0.4-0.5
Conditioned reinforcement - inactives0.50.51.21.10.6-0.0
Conditioned locomotion3.64.36.9-2.31.0-2.6
Intermittent access intake day 1-15 change1.11.12.1-0.70.9-1.4
Intermittent access intake escalation1.61.62.7-0.11.6-1.5
Intermittent access intake escalation 22.12.13.0-0.51.7-1.7
Intermitt. access day 1 inactive lever presses1.21.32.3-0.01.5-1.3
Intermitt. access day 15 inactive lever presses1.71.92.8-0.71.6-1.7
Intermitt. access escalation Index0.60.61.0-0.8-1.0-0.2
Intermittent access day 1 total infusions0.40.40.50.4-0.70.7
Intermittent access day 15 total infusions0.10.10.10.30.3-0.3
Intermittent access terminal intake (last 3 days)0.10.10.20.0-0.50.0
Intermittent access total infusions0.10.10.30.5-0.30.3
Intermittent access day 1 locomotion0.00.00.00.10.00.0
Intermittent access day 15 total locomotion1.21.32.3-0.81.0-1.5
Intermittent access total locomotion0.30.30.5-0.60.3-0.7
Intermittent access standard deviation0.80.81.4-0.50.9-1.2
Cocaine induced anxiety0.91.12.5-1.6-0.4-0.8
Post-drug Anxiety0.91.01.9-1.0-1.40.2
Baseline Anxiety0.10.10.20.20.4-0.1
Lifetime Intake0.50.60.70.7-0.90.7
Incentive Sensitization - Responses0.20.20.4-0.50.2-0.6
Incentive Sensitization - Breakpoint0.30.30.5-0.60.1-0.7
Progressive ratio test 1 active lever presses0.70.71.21.1-0.50.9
Progressive ratio test 1 breakpoint0.90.91.21.1-0.71.0
Progressive ratio test 1 inactive lever presses0.30.30.8-0.40.1-0.9
Progressive ratio test 2 active lever presses0.20.20.20.5-0.40.3
Progressive ratio test 2 breakpoint0.10.10.4-0.1-0.70.1
Progressive ratio test 2 inactive lever presses0.10.10.30.1-0.60.0
Total sessions with >9 infusions0.60.61.8-0.3-1.30.2
Short access day 1 total inactive lever presses0.10.10.2-0.20.0-0.4
Short access day 10 total inactive lever presses0.60.71.10.11.1-0.9
Short access day 1 total infusions0.91.02.60.1-1.60.6
Short access day 10 total infusions0.30.30.40.6-0.60.5
Short access total infusions1.41.52.70.7-1.61.1
Short access day 1 locomotion0.30.30.5-0.7-0.4-0.5
Short access day 10 total locomotion3.23.55.8-1.41.7-2.4
Short access total locomotion0.40.40.8-0.70.1-0.9
Compulsive drug intake0.30.30.60.6-0.40.7
One hour access (0.3 mA shock)0.20.30.40.6-0.30.5
One hour access (shock baseline)0.10.10.20.20.5-0.4
Number of responses in last shaping day1.71.73.0-1.30.7-1.7
Context. condit. distance diff. score0.20.20.30.6-0.10.5
Locomotion velocity, session 10.91.02.2-0.0-1.50.9
Locomotion distance, session 10.60.81.7-0.8-1.30.2
Locomotion velocity, session 21.31.53.0-1.7-1.0-0.7
Locomotion distance, session 21.52.25.1-2.2-0.6-1.1
Locomotion velocity, session 33.84.45.7-2.31.5-2.4
Locomotion distance, session 30.10.10.2-0.10.4-0.3
Stereotopy head waving bouts, day 34.75.68.4-2.91.1-2.7
Stereotopy head waving duration, day 33.74.56.2-2.51.0-2.5
Locomotion velocity, session 70.10.10.2-0.4-0.3-0.1
Locomotion distance, session 70.20.20.40.50.70.1
Stereotopy head waving bouts, day 70.60.71.5-1.2-0.6-0.5
Stereotopy head waving duration, day 70.60.71.3-1.1-0.9-0.2
Locomotion velocity, session 81.01.22.3-1.5-1.0-0.3
Locomotion distance, session 80.10.20.5-0.7-0.1-0.3
Degree of sensitization distance0.50.50.70.7-0.50.8
Degree of sensitization stereotypy0.60.61.20.1-1.10.8
Condit. Reinf. active minus inactive responses1.71.92.7-1.70.7-1.6
Condit. Reinf. active-inactive response ratio0.50.60.9-0.50.8-0.9
Condit. Reinf. active responses2.12.64.9-2.20.2-1.7
Condit. Reinf. inactive responses1.01.22.7-1.6-0.5-0.8
Incentive salience index mean0.91.12.3-1.5-0.2-0.9
Condit. Reinf. lever presses0.81.12.4-0.9-1.50.4
Time in familiar zone, hab. session 14.34.15.2-2.01.8-2.3
Time in novel zone, hab. session 14.03.95.11.4-2.32.1
Total zone transitions, hab. session 10.50.71.2-1.1-0.9-0.1
Total locomotion distance, hab. session 11.52.24.5-2.1-1.2-0.8
Locomotion velocity, hab. session 11.41.94.3-2.1-0.7-1.0
Time in familiar zone, hab. session 25.45.67.4-2.02.3-2.7
Time in novel zone, hab. session 26.06.07.82.0-2.52.8
Total zone transitions, hab. session 21.62.04.30.2-2.11.3
Total locomotion distance, hab. session 20.40.50.8-0.9-0.90.0
Locomotion velocity, hab. session 20.60.81.4-1.0-1.20.1
Novel to familiar place preference ratio3.73.95.21.3-2.32.2
Novelty place preference2.62.74.00.9-2.01.8
Time in novel zone, NPP test3.03.14.21.2-2.01.9
Total zone transitions, NPP test0.81.11.70.5-1.31.2
Total locomotion distance, NPP test0.60.81.8-0.1-1.40.8
Locomotion velocity, NPP test0.40.51.2-0.4-1.10.5
Pavlov. Cond. lever latency0.40.51.10.61.1-0.3
Pavlov. Cond. magazine entry latency1.31.72.2-1.41.1-1.5
Pavlov. Cond. change in total contacts0.10.10.20.3-0.40.4
Pavlov. Cond. index score0.30.40.9-0.9-0.3-0.4
Pavlov. Cond. latency score0.40.61.2-1.1-0.6-0.3
Pavlov. Cond. lever contacts0.70.82.0-0.5-1.40.6
Pavlov. Cond. magazine entry number0.40.50.70.8-0.40.7
Pavlov. Cond. intertrial magazine entries0.30.40.90.10.9-0.5
Pavlov. Cond. lever-magazine prob. diff.0.40.51.1-1.1-0.2-0.5
Pavlov. Cond. response bias0.40.50.9-0.90.4-0.7
Bone: apparent density1.32.25.4-0.8-2.30.7
Bone surface2.34.08.9-1.7-3.00.3
Bone volume2.44.19.9-1.5-3.10.6
Bone: connectivity density0.71.12.8-0.7-1.70.4
Bone: cortical apparent density0.91.21.71.3-0.71.2
Bone: cortical area1.32.04.00.5-2.01.3
Bone: cortical porosity0.20.20.2-0.5-0.5-0.2
Bone: cortical porosity0.40.41.1-0.2-1.00.3
Bone: cortical thickness1.32.12.51.2-1.61.6
Bone: cortical thickness0.60.81.41.2-0.10.9
Bone: cortical tissue density0.70.91.31.1-0.51.0
Bone: elastic displacement0.00.00.0-0.2-0.2-0.1
Bone: elastic work0.81.11.40.7-1.21.2
Bone: endosteal estimation0.61.21.90.7-1.41.1
Bone: endosteal perimeter0.30.71.3-1.1-0.7-0.5
Bone: final force3.04.86.11.6-2.42.5
Bone: final moment2.84.65.81.6-2.42.4
Bone: marrow area0.51.11.70.6-1.31.1
Bone: maximum diameter0.51.01.7-1.3-1.0-0.5
Bone: maximum force2.95.06.41.8-2.32.5
Bone: maximum moment2.84.96.21.7-2.32.5
Bone: minimum diameter0.40.71.80.0-1.30.7
Bone: periosteal estimation1.32.75.10.6-2.31.6
Bone: periosteal perimeter0.50.82.1-0.6-1.40.3
Bone: post-yield work0.30.30.40.7-0.40.6
Bone: stiffness4.16.48.32.4-2.32.9
Bone: tissue strength3.63.54.41.9-1.62.1
Bone: trabecular number0.71.22.1-1.5-1.1-0.4
Bone: trabecular spacing1.52.04.41.22.1-0.4
Bone: trabecular thickness3.44.110.2-0.9-3.21.1
Bone: trabecular tissue density3.85.39.63.1-0.72.4
Breakpoint value in progressive ratio session2.22.43.3-1.41.5-1.8
Distance traveled before self-admin0.60.61.1-1.00.4-0.8
Distance traveled after self-admin0.20.20.4-0.6-0.0-0.5
Delta time in closed arm before/after self-admin1.41.42.41.31.5-0.1
Delta time in open arm before/after self-admin2.32.23.71.2-1.21.9
Diff in mean of infusions in LGA sessions2.12.43.3-1.61.1-1.8
Extinction: sum of active levers before priming3.03.14.1-1.22.0-1.9
Active lever presses in extinction session 60.60.61.2-1.10.2-0.8
Delta distance traveled before/after self-admin0.00.00.1-0.0-0.30.0
Delta ambulatory time before/after self-admin0.20.20.6-0.1-0.80.3
Time in closed arm before self-admin0.80.92.00.0-1.40.9
Time in closed arm after self-admin0.00.00.10.3-0.10.0
Time in open arm before self-admin1.31.42.4-0.71.1-1.6
Time in open arm after self-admin0.91.01.71.3-0.31.2
Sum of active levers in priming session hrs 5-60.30.30.3-0.50.5-0.6
Time to tail flick, vehicle, before self-admin1.71.83.5-1.9-0.6-1.2
Time to tail flick, vehicle, after self-admin0.60.61.3-0.11.1-0.8
Time to tail flick, test, before self-admin1.01.01.9-1.4-0.6-0.8
Time to tail flick, test, after self-admin0.40.40.7-0.6-0.9-0.1
Delta time to tail flick, vehicle, before/after SA1.51.42.81.70.81.0
Delta time to tail flick, test, before/after SA0.30.20.60.10.8-0.2
Ambulatory time before self-admin0.20.20.3-0.50.3-0.4
Ambulatory time after self-admin0.00.00.1-0.3-0.1-0.1
Total heroin consumption1.51.83.0-1.70.5-1.4
Area under the delay curve0.30.30.50.2-0.70.7
Delay disc. indifference point, 0s delay3.43.76.10.7-2.52.1
Delay disc. indifference point, 16s delay0.10.10.2-0.4-0.0-0.2
Delay disc. indifference point, 2s delay0.70.81.20.4-1.11.1
Delay disc. indifference point, 24s delay0.70.71.10.7-0.71.0
Delay disc. indifference point, 4s delay0.40.40.6-0.8-0.7-0.1
Delay disc. indifference point, 8s delay0.20.20.40.60.30.4
Delay discount exponential model param0.20.20.4-0.10.5-0.6
Delay discount hyperbolic model param0.40.40.7-0.30.7-0.8
Fecal boli incidents, locomotor time 10.70.81.61.30.40.7
Change in fecal boli incidents, locomotor task0.70.71.2-1.1-0.8-0.3
Time >=10cm from walls, locomotor time 11.11.12.00.4-1.41.1
Bouts of movement, locomotor time 10.50.50.7-0.70.6-0.9
Total resting periods, locomotor time 10.91.01.3-1.10.7-1.1
Rest time, locomotor task time 10.20.30.6-0.80.0-0.5
Distance moved, locomotor task time 10.91.02.00.4-1.41.0
Vertical activity count, locomotor time 10.50.61.11.0-0.30.7
Time >=10cm from walls, locomotor time 20.70.71.51.2-0.10.8
Bouts of movement, locomotor time 20.40.40.7-0.8-0.7-0.2
Total resting periods, locomotor time 20.50.50.8-0.9-0.9-0.2
Rest time, locomotor task time 20.20.20.6-0.4-0.80.2
Distance moved, locomotor task time 20.20.20.50.40.7-0.2
Vertical activity count, locomotor time 21.01.12.41.50.40.8
Weight adjusted by age0.20.20.40.20.6-0.3
Seeking ratio, delayed vs. immediate footshock1.31.52.5-1.60.2-1.4
Locomotion in novel chamber0.10.10.20.4-0.20.2
Locomotion in novel chamber post-restriction2.63.14.0-2.01.3-1.9
Progressive ratio0.60.71.41.2-0.30.8
Food seeking constrained by brief footshock0.81.01.4-1.20.8-1.0
Seeking ratio, punishment vs. effort1.31.52.4-1.50.8-1.2
Run reversals in cocaine runway, females1.21.12.3-1.50.2-1.0
Run reversals in cocaine runway, males1.81.83.2-1.80.4-1.4
Latency to leave start box in cocaine runway1.11.22.8-0.2-1.70.8
Latency to leave start box in cocaine runway, F2.12.35.2-0.2-2.31.3
Latency to leave start box in cocaine runway, M0.30.30.60.30.8-0.4
Cd content in liver0.40.40.60.5-0.60.8
Co content in liver1.31.62.0-1.01.3-1.4
Cu content in liver1.21.52.80.6-1.71.2
Fe content in liver0.30.30.80.90.20.5
K content in liver0.60.61.1-1.1-0.5-0.6
Mg content in liver0.50.60.9-0.9-0.9-0.1
Mn content in liver1.51.73.2-1.4-1.8-0.1
Na content in liver0.30.40.70.2-0.80.6
Rb content in liver0.80.92.40.1-1.60.6
Se content in liver0.00.00.1-0.3-0.1-0.1
Sr content in liver1.11.02.2-0.01.5-0.9
Zn content in liver2.83.15.7-0.82.4-1.8