# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | alternative TSS | ENSRNOT00000028651 | 0.0287 | 0.0196 | 9.2e-03 | -0.002 | -0.002 | -0.001 | -0.002 | 5.9e-01 | 9.7e-01 | 4.3e-01 | 6.7e-01 |
2 | Adipose | gene expression | ENSRNOG00000021103 | 0.0470 | 0.0280 | 2.9e-04 | 0.022 | 0.018 | 0.008 | 0.013 | 1.5e-03 | 3.6e-03 | 3.9e-02 | 1.3e-02 |
3 | BLA | gene expression | ENSRNOG00000021103 | 0.0425 | 0.0309 | 8.7e-03 | 0.015 | 0.028 | 0.022 | 0.013 | 5.0e-02 | 1.3e-02 | 2.3e-02 | 6.7e-02 |
4 | BLA | intron excision ratio | chr1:203763525:203780407 | 0.0630 | 0.0400 | 6.1e-04 | 0.050 | 0.043 | 0.031 | 0.039 | 1.1e-03 | 2.4e-03 | 8.4e-03 | 3.5e-03 |
5 | BLA | intron excision ratio | chr1:203802213:203813559 | 0.0780 | 0.0610 | 5.7e-03 | 0.030 | 0.013 | 0.012 | 0.024 | 9.7e-03 | 6.0e-02 | 7.3e-02 | 1.9e-02 |
6 | Brain | alternative TSS | ENSRNOT00000028651 | 0.0414 | 0.0261 | 2.8e-04 | 0.025 | 0.035 | 0.034 | 0.033 | 2.2e-03 | 2.9e-04 | 3.9e-04 | 4.3e-04 |
7 | Brain | alternative TSS | ENSRNOT00000031227 | 0.0346 | 0.0220 | 4.9e-04 | 0.027 | 0.030 | 0.021 | 0.021 | 1.3e-03 | 7.3e-04 | 4.4e-03 | 4.2e-03 |
8 | Brain | intron excision ratio | chr1:203763525:203780407 | 0.0378 | 0.0261 | 4.0e-03 | 0.013 | 0.026 | 0.021 | 0.016 | 2.2e-02 | 1.7e-03 | 4.6e-03 | 1.1e-02 |
9 | IL | gene expression | ENSRNOG00000021103 | 0.1980 | 0.1160 | 1.4e-03 | 0.117 | 0.086 | 0.054 | 0.097 | 9.7e-04 | 4.3e-03 | 2.0e-02 | 2.6e-03 |
10 | Liver | isoform ratio | ENSRNOT00000028651 | 0.0408 | 0.0300 | 4.5e-03 | 0.004 | 0.007 | 0.022 | 0.003 | 1.1e-01 | 4.4e-02 | 1.4e-03 | 1.3e-01 |
11 | NAcc | gene expression | ENSRNOG00000021103 | 0.0570 | 0.0400 | 2.7e-04 | 0.060 | 0.038 | 0.093 | 0.055 | 2.8e-05 | 7.4e-04 | 2.0e-07 | 5.7e-05 |
12 | OFC | alternative TSS | ENSRNOT00000028651 | 0.1280 | 0.0850 | 8.1e-03 | 0.018 | 0.018 | -0.012 | 0.003 | 1.2e-01 | 1.2e-01 | 9.0e-01 | 2.7e-01 |
13 | OFC | gene expression | ENSRNOG00000021103 | 0.2115 | 0.1290 | 1.3e-03 | 0.081 | 0.099 | 0.082 | 0.090 | 5.7e-03 | 2.5e-03 | 5.5e-03 | 3.8e-03 |
14 | OFC | intron excision ratio | chr1:203763525:203780407 | 0.3091 | 0.1602 | 4.2e-04 | 0.099 | 0.091 | 0.066 | 0.103 | 2.5e-03 | 3.6e-03 | 1.2e-02 | 2.1e-03 |
15 | OFC | intron excision ratio | chr1:203825787:203827758 | 0.1669 | 0.1016 | 1.3e-03 | 0.075 | 0.056 | 0.019 | 0.058 | 7.8e-03 | 1.9e-02 | 1.1e-01 | 1.7e-02 |
16 | OFC | intron excision ratio | chr1:203827836:203840363 | 0.2554 | 0.1319 | 4.8e-05 | 0.171 | 0.081 | 0.067 | 0.110 | 7.5e-05 | 5.7e-03 | 1.1e-02 | 1.5e-03 |
17 | PL | alternative TSS | ENSRNOT00000028651 | 0.0590 | 0.0370 | 1.4e-04 | 0.051 | 0.045 | 0.045 | 0.046 | 9.5e-05 | 2.4e-04 | 2.3e-04 | 1.9e-04 |
18 | PL | gene expression | ENSRNOG00000021103 | 0.0793 | 0.0457 | 7.3e-06 | 0.066 | 0.062 | 0.058 | 0.065 | 9.3e-06 | 1.8e-05 | 3.0e-05 | 1.0e-05 |
19 | PL | intron excision ratio | chr1:203763525:203772110 | 0.0328 | 0.0239 | 6.8e-03 | 0.033 | 0.021 | 0.005 | 0.018 | 1.5e-03 | 9.5e-03 | 1.1e-01 | 1.5e-02 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
One hour access (shock baseline) | 11.8 | 13.7 | 19.6 | -3.8 | -4.2 | -3.8 | 4.1 | 1.2 | 4.0 | -4.2 | 3.2 | -4.1 | 4.0 | -1.5 | 3.6 | -4.4 | 3.9 | 3.6 | -4.1 | 3.6 | -2.9 | -4.2 |
One hour access (0.3 mA shock) | 10.6 | 12.3 | 15.7 | -2.8 | -3.9 | -3.9 | 3.9 | 1.4 | 3.8 | -3.9 | 3.3 | -3.9 | 2.9 | -0.7 | 3.7 | -4.0 | 3.9 | 3.8 | -3.9 | 3.7 | -3.4 | -3.9 |
Progressive ratio test 2 inactive lever presses | 9.9 | 11.5 | 15.0 | -2.9 | -3.7 | -3.6 | 3.7 | 1.3 | 3.7 | -3.8 | 3.1 | -3.7 | 3.0 | -1.3 | 3.6 | -3.9 | 3.6 | 3.6 | -3.8 | 3.4 | -3.4 | -3.7 |
Intermittent access day 15 total infusions | 9.7 | 10.8 | 14.5 | -3.1 | -3.7 | -3.4 | 3.6 | 0.6 | 3.8 | -3.8 | 2.6 | -3.6 | 3.1 | -1.6 | 3.4 | -3.8 | 3.4 | 3.4 | -3.6 | 3.3 | -3.0 | -3.7 |
Conditioned locomotion | 8.9 | 10.7 | 14.4 | -2.0 | -3.7 | -3.8 | 3.6 | 2.3 | 3.0 | -3.2 | 3.7 | -3.6 | 2.4 | -0.2 | 3.6 | -3.6 | 3.8 | 3.6 | -3.7 | 3.3 | -2.9 | -3.7 |
Tibialis anterior weight | 8.6 | 29.6 | 42.7 | 2.5 | 5.9 | 6.2 | -5.9 | -2.4 | -5.6 | 5.8 | -5.5 | 5.8 | -3.2 | 0.7 | -6.5 | 5.2 | -6.0 | -6.5 | 5.9 | -6.5 | 6.4 | 5.9 |
Intermittent access total locomotion | 7.5 | 8.4 | 14.6 | -3.0 | -3.2 | -2.7 | 3.1 | -0.6 | 3.8 | -3.7 | 1.6 | -3.1 | 2.8 | -2.4 | 2.9 | -3.2 | 2.7 | 2.8 | -3.2 | 2.9 | -2.8 | -3.2 |
Intermittent access terminal intake (last 3 days) | 7.4 | 8.0 | 12.0 | -3.2 | -3.1 | -2.7 | 3.0 | -0.1 | 3.5 | -3.4 | 1.9 | -3.0 | 3.1 | -1.7 | 2.8 | -3.4 | 2.7 | 2.8 | -3.1 | 2.7 | -2.6 | -3.1 |
Progressive ratio test 2 breakpoint | 7.0 | 7.7 | 10.0 | -2.4 | -3.1 | -3.0 | 3.1 | 1.3 | 2.8 | -2.9 | 2.7 | -3.2 | 2.7 | -0.7 | 2.9 | -3.2 | 3.1 | 2.9 | -3.1 | 2.8 | -2.4 | -3.1 |
Conditioned reinforcement - inactives | 6.9 | 7.8 | 10.9 | -2.4 | -3.1 | -3.2 | 3.0 | 2.0 | 2.6 | -2.8 | 3.0 | -3.0 | 2.8 | 0.2 | 2.7 | -3.3 | 3.2 | 2.8 | -3.0 | 2.8 | -2.6 | -3.1 |
Intermittent access total infusions | 6.3 | 6.9 | 11.1 | -2.9 | -2.9 | -2.4 | 2.9 | -0.3 | 3.3 | -3.2 | 1.5 | -2.9 | 2.4 | -2.2 | 2.6 | -2.9 | 2.5 | 2.7 | -2.9 | 2.5 | -2.4 | -2.9 |
Extensor digitorum longus weight | 6.2 | 25.1 | 35.2 | 2.4 | 5.3 | 5.9 | -5.4 | -3.3 | -4.6 | 5.0 | -5.7 | 5.3 | -3.2 | 0.2 | -5.8 | 5.1 | -5.7 | -5.8 | 5.4 | -5.8 | 5.7 | 5.3 |
Intermittent access day 1 total infusions | 6.2 | 7.0 | 12.6 | -2.5 | -3.0 | -2.4 | 2.9 | -0.8 | 3.6 | -3.4 | 1.3 | -2.9 | 1.6 | -2.5 | 2.8 | -2.7 | 2.4 | 2.9 | -2.9 | 2.7 | -2.9 | -3.0 |
Progressive ratio test 2 active lever presses | 5.9 | 6.3 | 8.7 | -2.5 | -2.9 | -2.6 | 2.8 | 0.7 | 2.8 | -2.8 | 2.2 | -2.8 | 2.3 | -1.0 | 2.5 | -2.9 | 2.7 | 2.5 | -2.8 | 2.5 | -2.1 | -2.9 |
Locomotion in novel chamber | 5.9 | 7.2 | 9.9 | -2.6 | -3.0 | -2.8 | 2.9 | 0.8 | 2.9 | -3.0 | 2.4 | -3.0 | 2.8 | -1.5 | 2.7 | -3.2 | 2.8 | 2.7 | -3.1 | 2.6 | -2.5 | -3.0 |
Intermittent access day 15 total locomotion | 5.6 | 5.9 | 8.4 | -2.2 | -2.8 | -2.6 | 2.7 | 0.4 | 2.9 | -2.9 | 2.0 | -2.7 | 2.2 | -1.0 | 2.5 | -2.9 | 2.6 | 2.3 | -2.7 | 2.5 | -2.1 | -2.8 |
Delay discounting water rate 12 sec | 5.3 | 7.9 | 14.6 | 0.2 | -2.7 | -3.6 | 2.6 | 2.8 | 2.1 | -2.4 | 3.8 | -2.7 | 1.0 | 1.3 | 3.8 | -2.3 | 3.1 | 3.7 | -2.8 | 3.8 | -2.9 | -2.7 |
Retroperitoneal fat weight | 5.1 | 16.7 | 23.4 | -3.2 | -4.4 | -4.3 | 4.3 | 0.3 | 4.8 | -4.8 | 3.2 | -4.3 | 2.9 | -2.3 | 4.7 | -4.2 | 4.1 | 4.6 | -4.6 | 4.6 | -4.8 | -4.4 |
Indifference point function ln k | 5.1 | 7.3 | 14.1 | -0.2 | -2.7 | -3.1 | 2.7 | 0.8 | 2.9 | -3.0 | 2.6 | -2.7 | 0.6 | -1.0 | 3.8 | -2.1 | 2.7 | 3.8 | -2.7 | 3.7 | -3.4 | -2.7 |
Indifference point function log k | 5.1 | 7.3 | 14.1 | -0.2 | -2.7 | -3.1 | 2.7 | 0.8 | 2.9 | -3.0 | 2.6 | -2.7 | 0.6 | -1.0 | 3.8 | -2.1 | 2.7 | 3.8 | -2.7 | 3.7 | -3.4 | -2.7 |
Lifetime Intake | 5.1 | 5.6 | 9.8 | -2.3 | -2.7 | -2.1 | 2.6 | -0.5 | 3.1 | -3.0 | 1.3 | -2.6 | 1.6 | -2.2 | 2.5 | -2.5 | 2.2 | 2.5 | -2.6 | 2.4 | -2.2 | -2.7 |
Reaction time premature initiations | 5.0 | 7.1 | 9.7 | 2.9 | 2.9 | 2.6 | -2.9 | -0.5 | -3.1 | 3.1 | -1.9 | 2.9 | -2.9 | 1.9 | -2.5 | 3.0 | -2.7 | -2.5 | 2.9 | -2.5 | 2.9 | 2.9 |
Total heroin consumption | 4.6 | 5.5 | 8.4 | 1.2 | 2.5 | 2.6 | -2.5 | -0.8 | -2.6 | 2.6 | -2.2 | 2.5 | -1.2 | 0.0 | -2.8 | 2.3 | -2.5 | -2.8 | 2.7 | -2.7 | 2.9 | 2.5 |
Compulsive drug intake | 4.4 | 4.3 | 9.4 | 2.6 | 2.2 | 1.8 | -2.1 | 0.3 | -2.6 | 2.5 | -1.1 | 2.1 | -3.1 | 2.0 | -1.8 | 2.5 | -1.8 | -1.7 | 2.2 | -1.8 | 1.4 | 2.2 |
Pavlov. Cond. magazine entry number | 4.1 | 5.0 | 9.3 | -0.4 | -2.2 | -2.7 | 2.2 | 1.1 | 2.3 | -2.4 | 2.4 | -2.2 | 0.8 | -0.0 | 3.0 | -2.0 | 2.3 | 3.0 | -2.3 | 3.0 | -2.8 | -2.2 |
Short access day 1 total inactive lever presses | 4.1 | 4.5 | 6.8 | -0.9 | -2.4 | -2.3 | 2.4 | 0.7 | 2.3 | -2.4 | 1.9 | -2.4 | 1.1 | -0.7 | 2.6 | -2.0 | 2.3 | 2.6 | -2.4 | 2.5 | -2.0 | -2.4 |
Saline control response | 4.0 | 5.3 | 7.1 | 1.7 | 2.7 | 2.6 | -2.6 | -1.0 | -2.3 | 2.4 | -2.3 | 2.6 | -1.4 | 0.2 | -2.5 | 2.5 | -2.7 | -2.5 | 2.6 | -2.4 | 2.4 | 2.7 |
Intermitt. access day 15 inactive lever presses | 3.9 | 4.3 | 6.0 | -1.9 | -2.3 | -2.2 | 2.4 | 1.0 | 2.1 | -2.2 | 1.9 | -2.4 | 2.2 | -0.2 | 2.0 | -2.5 | 2.4 | 2.0 | -2.3 | 1.9 | -2.2 | -2.3 |
Reaction time premature initiation rate | 3.7 | 4.9 | 7.1 | 2.5 | 2.4 | 2.2 | -2.4 | -0.8 | -2.4 | 2.5 | -1.8 | 2.4 | -2.7 | 1.6 | -2.0 | 2.6 | -2.3 | -1.9 | 2.5 | -1.9 | 2.2 | 2.4 |
Intermittent access day 1 locomotion | 3.6 | 3.7 | 7.9 | -1.2 | -2.1 | -1.6 | 2.0 | -1.1 | 2.8 | -2.6 | 0.6 | -2.0 | 0.9 | -2.0 | 2.2 | -1.7 | 1.6 | 2.1 | -2.0 | 2.2 | -2.4 | -2.1 |
Progressive ratio test 1 active lever presses | 3.6 | 3.7 | 4.9 | -1.6 | -2.2 | -2.1 | 2.1 | 0.8 | 2.0 | -2.1 | 1.8 | -2.1 | 1.5 | -0.3 | 2.1 | -2.1 | 2.1 | 2.1 | -2.2 | 2.0 | -1.9 | -2.2 |
Extinction: sum of active levers before priming | 3.5 | 3.6 | 5.4 | 0.6 | 2.1 | 2.3 | -2.1 | -1.3 | -1.8 | 1.9 | -2.1 | 2.1 | -0.8 | -0.2 | -2.2 | 1.9 | -2.2 | -2.3 | 2.0 | -2.3 | 1.8 | 2.1 |
Body weight | 3.3 | 14.1 | 23.4 | 1.5 | 4.0 | 4.6 | -4.1 | -4.1 | -2.8 | 3.2 | -4.8 | 4.1 | -2.9 | -0.9 | -4.0 | 3.7 | -4.6 | -4.0 | 3.9 | -4.1 | 3.7 | 4.0 |
Soleus weight | 3.3 | 9.5 | 14.2 | -1.6 | -3.3 | -3.5 | 3.3 | 1.3 | 3.3 | -3.4 | 3.0 | -3.3 | 1.9 | -1.0 | 3.7 | -3.0 | 3.2 | 3.8 | -3.3 | 3.7 | -3.6 | -3.3 |
Delay discounting total patch changes 12 sec | 3.3 | 4.5 | 7.2 | 0.9 | 2.2 | 2.4 | -2.2 | -0.8 | -2.3 | 2.3 | -2.1 | 2.2 | -1.2 | 0.8 | -2.6 | 2.0 | -2.2 | -2.6 | 2.2 | -2.7 | 2.5 | 2.2 |
Progressive ratio test 1 breakpoint | 3.2 | 3.3 | 4.3 | -1.5 | -2.0 | -2.0 | 1.9 | 0.9 | 1.8 | -1.9 | 1.8 | -2.0 | 1.5 | -0.2 | 2.0 | -2.0 | 1.9 | 2.0 | -2.1 | 1.9 | -1.7 | -2.0 |
Delay discounting water rate 0 sec | 3.1 | 5.0 | 9.5 | -0.5 | -2.1 | -2.8 | 2.1 | 2.6 | 1.6 | -1.9 | 3.1 | -2.3 | 1.5 | 0.8 | 2.7 | -2.2 | 2.6 | 2.7 | -2.3 | 2.8 | -1.9 | -2.1 |
Short access day 1 total infusions | 3.1 | 3.3 | 5.8 | -1.5 | -2.1 | -1.6 | 2.0 | -0.4 | 2.4 | -2.3 | 0.9 | -2.0 | 0.6 | -2.1 | 2.1 | -1.6 | 1.7 | 2.1 | -2.0 | 2.0 | -1.9 | -2.1 |
Bone: trabecular tissue density | 3.1 | 4.3 | 5.9 | -1.3 | -2.3 | -2.4 | 2.2 | 1.4 | 2.0 | -2.1 | 2.3 | -2.2 | 1.4 | 0.1 | 2.3 | -2.2 | 2.3 | 2.3 | -2.2 | 2.3 | -2.4 | -2.3 |
Locomotion in novel chamber post-restriction | 3.1 | 3.6 | 5.6 | -1.6 | -2.0 | -2.1 | 2.0 | 0.7 | 2.0 | -2.1 | 1.8 | -2.0 | 1.6 | -0.6 | 2.1 | -2.1 | 2.0 | 2.1 | -2.0 | 2.1 | -2.4 | -2.0 |
Time to tail flick, vehicle, after self-admin | 2.9 | 3.1 | 5.3 | 1.3 | 2.1 | 2.0 | -2.1 | -2.1 | -1.0 | 1.3 | -2.3 | 2.1 | -1.5 | -0.2 | -1.6 | 1.9 | -2.3 | -1.6 | 2.0 | -1.3 | 1.1 | 2.1 |
BMI with tail | 2.8 | 9.2 | 28.6 | -0.0 | 2.9 | 3.8 | -3.0 | -5.3 | -0.8 | 1.4 | -5.0 | 2.9 | -1.5 | -3.0 | -2.8 | 2.8 | -3.9 | -2.8 | 2.8 | -2.7 | 2.3 | 2.9 |
Pavlov. Cond. magazine entry latency | 2.7 | 3.1 | 5.3 | 0.6 | 1.8 | 2.1 | -1.9 | -0.9 | -1.8 | 1.8 | -1.9 | 1.8 | -0.9 | 0.2 | -2.3 | 1.7 | -1.9 | -2.3 | 1.9 | -2.2 | 1.9 | 1.8 |
Intermitt. access day 1 inactive lever presses | 2.7 | 2.9 | 4.5 | -1.1 | -1.8 | -1.9 | 1.9 | 0.7 | 1.7 | -1.8 | 1.7 | -1.9 | 1.4 | 0.3 | 1.9 | -1.8 | 1.9 | 1.8 | -1.8 | 1.7 | -2.1 | -1.8 |
Short access day 10 total inactive lever presses | 2.7 | 2.9 | 5.1 | 0.3 | -1.7 | -2.1 | 1.8 | 1.2 | 1.6 | -1.7 | 1.9 | -1.8 | 0.3 | 0.5 | 2.3 | -1.3 | 1.9 | 2.2 | -1.7 | 2.2 | -2.3 | -1.7 |
Sr content in liver | 2.7 | 2.5 | 4.2 | 0.8 | 1.7 | 1.5 | -1.7 | 0.4 | -2.0 | 2.0 | -0.9 | 1.5 | -0.7 | 1.4 | -2.0 | 1.3 | -1.4 | -2.0 | 1.7 | -2.0 | 2.0 | 1.7 |
Bone: cortical thickness | 2.6 | 4.4 | 6.7 | 1.9 | 2.4 | 2.0 | -2.3 | 0.3 | -2.6 | 2.5 | -1.3 | 2.3 | -1.9 | 1.7 | -2.3 | 2.1 | -2.0 | -2.2 | 2.3 | -2.0 | 2.0 | 2.4 |
Locomotion velocity, session 2 | 2.5 | 2.9 | 4.6 | 0.9 | 1.8 | 2.1 | -1.8 | -1.3 | -1.4 | 1.6 | -2.2 | 1.8 | -1.2 | -0.8 | -1.9 | 1.8 | -2.0 | -1.9 | 1.9 | -1.9 | 1.6 | 1.8 |
Bone surface | 2.5 | 4.4 | 9.4 | -0.9 | 1.8 | 2.7 | -1.9 | -2.8 | -1.2 | 1.5 | -3.1 | 1.9 | -0.1 | -1.6 | -2.8 | 1.5 | -2.3 | -2.8 | 1.8 | -2.8 | 2.2 | 1.8 |
Epididymis fat weight | 2.4 | 5.5 | 8.8 | -2.0 | -2.4 | -2.4 | 2.4 | -0.5 | 3.0 | -2.9 | 1.7 | -2.5 | 1.7 | -1.3 | 2.6 | -2.6 | 2.2 | 2.5 | -2.5 | 2.6 | -2.9 | -2.4 |
Heart weight | 2.4 | 3.4 | 6.0 | -0.4 | -1.9 | -2.1 | 1.9 | 0.3 | 2.2 | -2.2 | 1.7 | -2.0 | 0.4 | -0.9 | 2.4 | -1.6 | 1.9 | 2.4 | -2.0 | 2.4 | -2.3 | -1.9 |
Indifference point AUC | 2.4 | 2.9 | 5.5 | 0.2 | 1.7 | 1.9 | -1.7 | -0.6 | -1.9 | 1.9 | -1.5 | 1.6 | -0.2 | 1.5 | -2.4 | 1.3 | -1.6 | -2.3 | 1.8 | -2.2 | 2.1 | 1.7 |
Delay discounting water rate 24 sec | 2.4 | 3.3 | 6.8 | -0.1 | -1.6 | -2.3 | 1.6 | 1.5 | 1.6 | -1.8 | 2.3 | -1.7 | 0.8 | 0.3 | 2.6 | -1.7 | 1.9 | 2.5 | -1.9 | 2.6 | -1.8 | -1.6 |
Light reinforcement 2 | 2.4 | 3.2 | 7.8 | -2.4 | -2.1 | -1.5 | 2.1 | 0.5 | 1.6 | -1.6 | 1.4 | -2.2 | 2.8 | -1.4 | 1.2 | -2.1 | 2.0 | 1.1 | -1.9 | 0.9 | -1.3 | -2.1 |
Short access day 10 total infusions | 2.4 | 2.7 | 7.4 | -1.6 | -1.7 | -1.0 | 1.6 | -1.6 | 2.5 | -2.2 | 0.0 | -1.6 | 0.6 | -2.7 | 1.6 | -1.4 | 1.1 | 1.7 | -1.6 | 1.4 | -1.5 | -1.7 |
Bone: endosteal perimeter | 2.3 | 4.6 | 10.7 | -3.3 | -2.2 | -1.2 | 2.1 | -2.1 | 2.9 | -2.7 | 0.1 | -2.1 | 2.5 | -3.1 | 1.5 | -2.2 | 1.4 | 1.5 | -2.1 | 1.4 | -1.9 | -2.2 |
Delay discounting water rate 6 sec | 2.2 | 3.2 | 7.8 | 0.7 | -1.5 | -2.3 | 1.5 | 1.7 | 1.4 | -1.5 | 2.4 | -1.6 | 0.4 | 0.9 | 2.6 | -1.3 | 1.9 | 2.6 | -1.6 | 2.8 | -1.7 | -1.5 |
Short access day 1 locomotion | 2.2 | 2.3 | 4.7 | -0.9 | -1.7 | -1.3 | 1.7 | -0.8 | 2.2 | -2.0 | 0.6 | -1.7 | 0.6 | -1.8 | 1.8 | -1.3 | 1.4 | 1.7 | -1.6 | 1.7 | -1.4 | -1.7 |
Bone: maximum force | 2.2 | 3.8 | 9.0 | -0.6 | 1.7 | 2.5 | -1.7 | -2.9 | -0.9 | 1.3 | -3.0 | 1.7 | -0.3 | -1.7 | -2.4 | 1.5 | -2.2 | -2.4 | 1.7 | -2.4 | 2.0 | 1.7 |
Rest time, locomotor task time 2 | 2.2 | 2.6 | 4.8 | -0.9 | -1.6 | -1.7 | 1.6 | 0.1 | 1.9 | -1.9 | 1.3 | -1.8 | 1.0 | 0.9 | 2.0 | -1.6 | 1.7 | 1.8 | -1.8 | 1.8 | -2.2 | -1.6 |
BMI without tail | 2.1 | 4.4 | 10.0 | 1.1 | 2.5 | 2.5 | -2.5 | -3.2 | -0.9 | 1.3 | -3.0 | 2.5 | -1.2 | -0.4 | -1.9 | 2.2 | -2.8 | -1.9 | 2.2 | -1.5 | 1.6 | 2.5 |
Bone: final force | 2.1 | 3.4 | 5.8 | 0.2 | 1.8 | 2.3 | -1.9 | -1.9 | -1.4 | 1.7 | -2.4 | 1.9 | -0.9 | -0.7 | -2.3 | 1.6 | -2.1 | -2.2 | 1.9 | -2.3 | 1.9 | 1.8 |
Glucose | 2.0 | 3.1 | 5.6 | -1.5 | -1.9 | -1.5 | 1.8 | -0.9 | 2.4 | -2.2 | 0.7 | -1.8 | 1.4 | -2.0 | 2.0 | -1.6 | 1.5 | 2.0 | -1.9 | 2.0 | -1.9 | -1.9 |
Delay discounting total patch changes 24 sec | 2.0 | 2.5 | 4.1 | 0.9 | 1.7 | 1.7 | -1.7 | -0.2 | -1.9 | 1.9 | -1.2 | 1.6 | -0.8 | 0.8 | -1.9 | 1.5 | -1.6 | -1.8 | 1.7 | -2.0 | 2.0 | 1.7 |
Condit. Reinf. active-inactive response ratio | 2.0 | 2.1 | 6.3 | -2.4 | -1.5 | -1.0 | 1.5 | -0.4 | 1.8 | -1.7 | 0.5 | -1.5 | 2.5 | -1.5 | 0.9 | -1.7 | 1.2 | 0.9 | -1.6 | 0.9 | -0.5 | -1.5 |
Baseline Anxiety | 2.0 | 2.1 | 2.8 | 1.4 | 1.5 | 1.6 | -1.5 | -0.5 | -1.6 | 1.7 | -1.3 | 1.5 | -1.3 | 0.4 | -1.6 | 1.6 | -1.5 | -1.6 | 1.6 | -1.6 | 1.5 | 1.5 |
Total sessions with >9 infusions | 2.0 | 2.2 | 4.4 | -0.9 | -1.6 | -1.2 | 1.6 | -0.9 | 2.1 | -1.9 | 0.5 | -1.6 | 0.5 | -1.4 | 1.8 | -1.2 | 1.3 | 1.8 | -1.6 | 1.6 | -1.6 | -1.6 |
Bone: post-yield work | 2.0 | 2.8 | 19.4 | -3.0 | -0.7 | 0.7 | 0.7 | -3.2 | 1.7 | -1.3 | -1.9 | -0.6 | 1.5 | -4.4 | -0.3 | -0.6 | -0.2 | -0.3 | -0.7 | -0.6 | 0.1 | -0.7 |
Breakpoint value in progressive ratio session | 2.0 | 2.2 | 4.5 | 0.2 | 1.5 | 1.8 | -1.5 | -0.8 | -1.6 | 1.6 | -1.5 | 1.4 | -0.4 | 0.4 | -2.1 | 1.3 | -1.5 | -2.1 | 1.7 | -1.9 | 1.6 | 1.5 |
Progressive ratio | 2.0 | 2.3 | 5.6 | -0.0 | 1.5 | 1.9 | -1.4 | -2.0 | -0.7 | 0.9 | -2.4 | 1.4 | -0.6 | -1.8 | -1.6 | 1.3 | -1.9 | -1.7 | 1.3 | -1.8 | 1.1 | 1.5 |
Parametrial fat weight | 1.9 | 3.8 | 7.6 | -1.9 | -2.1 | -1.7 | 1.9 | -1.1 | 2.8 | -2.6 | 0.8 | -2.0 | 1.4 | -1.6 | 2.0 | -1.9 | 1.6 | 2.0 | -2.0 | 2.1 | -2.3 | -2.1 |
Bone: maximum moment | 1.9 | 3.3 | 7.9 | -0.6 | 1.6 | 2.4 | -1.6 | -2.7 | -0.8 | 1.2 | -2.8 | 1.6 | -0.3 | -1.6 | -2.2 | 1.4 | -2.1 | -2.2 | 1.6 | -2.2 | 1.8 | 1.6 |
Length with tail | 1.8 | 6.6 | 9.1 | 2.0 | 2.7 | 2.7 | -2.8 | -0.8 | -2.9 | 3.0 | -2.2 | 2.8 | -2.4 | 1.4 | -2.9 | 2.5 | -2.7 | -2.9 | 2.8 | -3.0 | 2.7 | 2.7 |
Delay discounting water rate 18 sec | 1.8 | 2.4 | 5.6 | 0.4 | -1.4 | -1.9 | 1.4 | 0.8 | 1.4 | -1.5 | 1.8 | -1.4 | 0.1 | -0.1 | 2.4 | -1.1 | 1.6 | 2.2 | -1.6 | 2.3 | -1.7 | -1.4 |
Reaction time mean minus median | 1.8 | 2.3 | 5.0 | -0.5 | 1.3 | 1.9 | -1.3 | -1.0 | -1.3 | 1.4 | -1.8 | 1.4 | -0.1 | -0.3 | -2.2 | 1.1 | -1.5 | -2.2 | 1.4 | -2.2 | 2.1 | 1.3 |
Short access total infusions | 1.8 | 2.0 | 4.3 | -1.1 | -1.5 | -1.0 | 1.5 | -1.1 | 2.1 | -1.9 | 0.2 | -1.5 | 0.1 | -2.1 | 1.6 | -1.1 | 1.1 | 1.6 | -1.4 | 1.4 | -1.3 | -1.5 |
Total zone transitions, NPP test | 1.8 | 2.6 | 4.3 | 0.7 | 1.6 | 2.0 | -1.6 | -1.5 | -1.3 | 1.5 | -2.1 | 1.6 | -1.2 | -0.5 | -1.8 | 1.6 | -1.8 | -1.8 | 1.7 | -2.0 | 1.8 | 1.6 |
Bone: connectivity density | 1.8 | 2.7 | 5.9 | 0.0 | 1.6 | 2.1 | -1.6 | -2.2 | -0.9 | 1.2 | -2.4 | 1.6 | -0.9 | -1.4 | -2.0 | 1.5 | -2.0 | -2.0 | 1.6 | -1.9 | 1.1 | 1.6 |
Bone: final moment | 1.8 | 3.0 | 5.2 | 0.1 | 1.7 | 2.2 | -1.8 | -1.8 | -1.3 | 1.5 | -2.3 | 1.8 | -0.8 | -0.7 | -2.2 | 1.5 | -2.0 | -2.1 | 1.8 | -2.1 | 1.8 | 1.7 |
Time >=10cm from walls, locomotor time 1 | 1.8 | 1.8 | 4.4 | -2.1 | -1.2 | -0.6 | 1.3 | -1.3 | 2.0 | -1.8 | -0.2 | -1.3 | 1.7 | -2.1 | 0.8 | -1.5 | 0.8 | 1.0 | -1.3 | 0.7 | -1.1 | -1.2 |
Weight adjusted by age | 1.8 | 2.0 | 5.1 | 0.5 | 1.6 | 1.6 | -1.5 | -0.7 | -1.4 | 1.5 | -1.3 | 1.5 | -0.4 | -0.1 | -1.7 | 1.1 | -1.5 | -1.7 | 1.4 | -1.8 | 2.3 | 1.6 |
K content in liver | 1.8 | 1.8 | 4.4 | 0.3 | 1.4 | 1.7 | -1.4 | -2.1 | -0.5 | 0.8 | -2.1 | 1.4 | -0.8 | -1.0 | -1.3 | 1.3 | -1.7 | -1.3 | 1.3 | -1.2 | 1.0 | 1.4 |
Intermitt. access escalation Index | 1.7 | 1.5 | 3.9 | -0.2 | -1.1 | -1.4 | 1.1 | 0.4 | 1.5 | -1.5 | 1.0 | -1.1 | 0.1 | -1.3 | 1.5 | -0.8 | 1.1 | 1.7 | -1.2 | 1.8 | -2.0 | -1.1 |
Intermittent access standard deviation | 1.7 | 1.8 | 2.9 | -1.1 | -1.4 | -1.5 | 1.4 | 1.0 | 1.2 | -1.3 | 1.5 | -1.4 | 1.7 | 0.5 | 1.3 | -1.6 | 1.5 | 1.4 | -1.5 | 1.2 | -1.1 | -1.4 |
Intraocular pressure | 1.6 | 2.2 | 6.1 | -1.3 | -1.3 | -1.6 | 1.4 | 2.5 | 0.8 | -1.1 | 2.0 | -1.3 | 2.3 | 0.2 | 1.1 | -1.9 | 1.5 | 1.0 | -1.6 | 1.4 | -0.6 | -1.3 |
Pavlov. Cond. lever-magazine prob. diff. | 1.6 | 2.1 | 4.5 | -0.3 | 1.3 | 1.8 | -1.4 | -1.0 | -1.3 | 1.4 | -1.8 | 1.4 | -0.0 | -0.6 | -2.1 | 1.1 | -1.5 | -2.1 | 1.4 | -2.1 | 1.8 | 1.3 |
Short access day 10 total locomotion | 1.6 | 1.8 | 3.5 | -0.9 | -1.4 | -1.1 | 1.3 | -0.5 | 1.9 | -1.8 | 0.5 | -1.3 | 0.9 | -1.7 | 1.4 | -1.2 | 1.1 | 1.4 | -1.4 | 1.5 | -1.5 | -1.4 |
Bone: stiffness | 1.6 | 2.5 | 5.6 | -0.8 | 1.3 | 2.1 | -1.3 | -2.1 | -0.8 | 1.1 | -2.4 | 1.3 | -0.1 | -1.5 | -2.1 | 1.1 | -1.7 | -2.0 | 1.3 | -2.2 | 1.8 | 1.3 |
Incentive Sensitization - Breakpoint | 1.5 | 1.5 | 2.6 | -1.5 | -1.4 | -1.1 | 1.3 | 0.4 | 1.3 | -1.3 | 0.9 | -1.4 | 1.6 | -0.8 | 1.0 | -1.5 | 1.2 | 1.0 | -1.3 | 1.1 | -0.8 | -1.4 |
Short access total locomotion | 1.5 | 1.5 | 3.2 | -0.7 | -1.3 | -1.0 | 1.3 | -0.8 | 1.8 | -1.6 | 0.3 | -1.3 | 0.5 | -1.7 | 1.4 | -0.9 | 1.0 | 1.4 | -1.3 | 1.3 | -1.2 | -1.3 |
Active lever presses in extinction session 6 | 1.5 | 1.4 | 3.5 | -0.2 | 1.1 | 1.4 | -1.1 | -0.1 | -1.4 | 1.4 | -1.0 | 1.1 | 0.1 | 0.0 | -1.9 | 0.7 | -1.1 | -1.9 | 1.3 | -1.7 | 1.4 | 1.1 |
Cd content in liver | 1.5 | 1.6 | 2.9 | -1.4 | -1.3 | -1.4 | 1.4 | 0.8 | 1.1 | -1.2 | 1.4 | -1.1 | 1.6 | 0.8 | 0.9 | -1.7 | 1.5 | 0.9 | -1.4 | 1.1 | -1.2 | -1.3 |
Locomotor testing distance | 1.4 | 2.3 | 5.4 | 1.4 | -1.1 | -1.8 | 1.1 | 1.0 | 1.0 | -1.1 | 1.9 | -1.0 | -0.3 | 2.0 | 2.3 | -0.8 | 1.3 | 2.2 | -1.3 | 2.3 | -1.8 | -1.1 |
Conditioned locomotion | 1.4 | 1.6 | 2.5 | 0.8 | 1.3 | 1.5 | -1.4 | -0.7 | -1.3 | 1.4 | -1.3 | 1.3 | -1.3 | 0.1 | -1.3 | 1.3 | -1.4 | -1.3 | 1.3 | -1.4 | 1.6 | 1.3 |
Bone: endosteal estimation | 1.4 | 3.0 | 8.4 | -2.3 | -1.6 | -0.8 | 1.5 | -2.2 | 2.5 | -2.2 | -0.3 | -1.5 | 1.6 | -2.9 | 1.3 | -1.5 | 0.9 | 1.3 | -1.5 | 1.3 | -1.8 | -1.6 |
Bone: marrow area | 1.4 | 3.0 | 8.5 | -2.2 | -1.6 | -0.9 | 1.6 | -2.2 | 2.6 | -2.3 | -0.2 | -1.6 | 1.5 | -2.9 | 1.4 | -1.5 | 0.9 | 1.4 | -1.5 | 1.3 | -1.8 | -1.6 |
Delay discounting time to switch 0 sec | 1.3 | 1.9 | 4.9 | -0.6 | 1.1 | 1.7 | -1.1 | -2.2 | -0.4 | 0.7 | -2.2 | 1.2 | -0.6 | -1.5 | -1.7 | 1.0 | -1.6 | -1.7 | 1.2 | -1.7 | 1.1 | 1.1 |
Pavlov. Cond. index score | 1.3 | 1.6 | 3.6 | -0.5 | 1.1 | 1.6 | -1.1 | -1.0 | -1.0 | 1.2 | -1.6 | 1.1 | 0.2 | -0.7 | -1.9 | 0.9 | -1.3 | -1.9 | 1.1 | -1.9 | 1.6 | 1.1 |
Total zone transitions, hab. session 2 | 1.3 | 1.7 | 3.9 | 0.5 | 1.2 | 1.6 | -1.2 | -1.7 | -0.6 | 0.9 | -2.0 | 1.2 | -1.4 | -1.4 | -1.2 | 1.4 | -1.5 | -1.1 | 1.3 | -1.4 | 1.2 | 1.2 |
Bone: cortical thickness | 1.3 | 1.5 | 3.6 | 1.9 | 1.3 | 0.9 | -1.2 | -0.0 | -1.4 | 1.4 | -0.5 | 1.3 | -1.6 | 1.9 | -0.9 | 1.3 | -1.0 | -0.8 | 1.3 | -0.8 | 0.8 | 1.3 |
Bone: elastic work | 1.3 | 1.7 | 3.9 | 2.0 | 1.5 | 1.1 | -1.4 | -0.1 | -1.4 | 1.4 | -0.7 | 1.4 | -1.7 | 1.6 | -0.9 | 1.5 | -1.2 | -0.9 | 1.5 | -0.7 | 0.9 | 1.5 |
Delta time to tail flick, test, before/after SA | 1.3 | 1.1 | 4.2 | 0.4 | 1.0 | 0.6 | -1.0 | 1.3 | -1.7 | 1.5 | 0.1 | 1.0 | 0.0 | 1.0 | -1.2 | 0.5 | -0.6 | -1.2 | 0.8 | -1.2 | 2.0 | 1.0 |
Rest time, locomotor task time 1 | 1.3 | 1.4 | 2.1 | -0.5 | -1.1 | -1.4 | 1.1 | 1.5 | 1.0 | -1.1 | 1.5 | -1.3 | 0.9 | 0.5 | 1.3 | -1.3 | 1.4 | 1.2 | -1.3 | 1.4 | -1.1 | -1.1 |
Co content in liver | 1.3 | 1.5 | 7.0 | 1.4 | -0.5 | -1.3 | 0.5 | 2.4 | -0.2 | -0.1 | 1.9 | -0.4 | -0.6 | 2.7 | 1.2 | -0.3 | 1.0 | 1.2 | -0.5 | 1.2 | -0.9 | -0.5 |
Mn content in liver | 1.3 | 1.5 | 3.5 | -0.3 | 1.2 | 1.5 | -1.1 | -0.4 | -1.2 | 1.2 | -1.3 | 1.0 | 0.1 | -0.4 | -1.9 | 0.9 | -1.2 | -1.9 | 1.2 | -1.6 | 1.8 | 1.2 |
Tail length | 1.2 | 3.6 | 7.7 | 2.3 | 2.1 | 1.5 | -2.1 | 0.1 | -2.4 | 2.3 | -0.8 | 2.1 | -1.5 | 2.8 | -1.8 | 1.8 | -1.7 | -1.8 | 2.1 | -1.5 | 1.7 | 2.1 |
Length without tail | 1.2 | 2.6 | 5.3 | 0.7 | 1.5 | 2.0 | -1.5 | -1.0 | -1.7 | 1.8 | -1.8 | 1.5 | -1.8 | -0.4 | -1.8 | 1.6 | -1.7 | -1.8 | 1.6 | -2.3 | 1.8 | 1.5 |
Mean time between licks in bursts | 1.2 | 1.7 | 4.6 | 2.1 | 1.4 | 1.1 | -1.4 | -0.1 | -1.3 | 1.4 | -0.8 | 1.4 | -2.0 | 1.2 | -0.8 | 1.7 | -1.3 | -0.7 | 1.5 | -0.5 | 0.8 | 1.4 |
Intermittent access intake day 1-15 change | 1.2 | 1.2 | 4.1 | -1.1 | -1.0 | -1.2 | 1.0 | 1.3 | 0.7 | -0.8 | 1.4 | -1.0 | 2.0 | 0.4 | 0.8 | -1.5 | 1.2 | 0.9 | -1.1 | 0.9 | -0.5 | -1.0 |
Locomotion velocity, session 8 | 1.2 | 1.5 | 2.3 | 1.4 | 1.4 | 1.3 | -1.3 | -1.0 | -1.2 | 1.3 | -1.2 | 1.3 | -1.3 | 0.6 | -1.1 | 1.4 | -1.3 | -1.1 | 1.5 | -1.1 | 0.7 | 1.4 |
Bone: minimum diameter | 1.2 | 2.3 | 5.7 | -2.0 | -1.5 | -0.8 | 1.4 | -1.8 | 2.2 | -2.0 | -0.1 | -1.4 | 1.6 | -2.4 | 1.2 | -1.3 | 0.9 | 1.2 | -1.4 | 1.1 | -1.6 | -1.5 |
Seeking ratio, punishment vs. effort | 1.2 | 1.5 | 3.6 | 1.0 | -0.9 | -1.6 | 0.9 | 1.6 | 0.4 | -0.6 | 1.9 | -0.9 | -0.3 | 1.7 | 1.4 | -0.6 | 1.3 | 1.5 | -0.7 | 1.7 | -1.3 | -0.9 |
Run reversals in cocaine runway, females | 1.2 | 1.2 | 3.5 | 1.3 | 0.9 | 1.2 | -1.0 | -1.7 | -0.3 | 0.5 | -1.6 | 1.0 | -1.9 | -1.0 | -0.6 | 1.5 | -1.2 | -0.6 | 1.1 | -0.6 | 0.4 | 0.9 |
Rb content in liver | 1.2 | 1.5 | 2.7 | -0.6 | -1.3 | -1.3 | 1.3 | -0.4 | 1.5 | -1.4 | 0.8 | -1.2 | 0.7 | -0.3 | 1.5 | -1.0 | 1.2 | 1.5 | -1.3 | 1.6 | -1.6 | -1.3 |
Water consumed over 24 hours | 1.1 | 1.3 | 2.7 | 1.2 | 1.1 | 0.8 | -1.2 | 0.8 | -1.6 | 1.4 | -0.3 | 1.2 | -0.9 | 1.6 | -1.1 | 1.1 | -0.9 | -1.0 | 1.1 | -1.0 | 1.1 | 1.1 |
Locomotor activity | 1.1 | 1.7 | 3.8 | 0.9 | -1.0 | -1.6 | 1.0 | 1.0 | 0.9 | -1.0 | 1.7 | -0.9 | 0.1 | 1.5 | 1.9 | -0.9 | 1.2 | 1.8 | -1.4 | 1.9 | -1.5 | -1.0 |
Locomotor testing rearing | 1.1 | 1.8 | 4.0 | 0.9 | -1.0 | -1.6 | 1.1 | 0.6 | 1.0 | -1.1 | 1.6 | -1.0 | 0.3 | 1.8 | 1.9 | -0.8 | 1.2 | 1.9 | -1.2 | 2.0 | -1.7 | -1.0 |
Intermittent access intake escalation | 1.1 | 1.0 | 3.3 | -1.1 | -1.0 | -1.1 | 1.0 | 1.1 | 0.7 | -0.9 | 1.2 | -1.0 | 1.8 | 0.1 | 0.8 | -1.3 | 1.1 | 0.8 | -1.0 | 0.8 | -0.4 | -1.0 |
Incentive Sensitization - Responses | 1.1 | 1.1 | 2.0 | -1.4 | -1.2 | -0.9 | 1.1 | 0.2 | 1.1 | -1.1 | 0.7 | -1.2 | 1.4 | -0.9 | 0.8 | -1.3 | 1.0 | 0.8 | -1.1 | 0.9 | -0.7 | -1.2 |
Progressive ratio test 1 inactive lever presses | 1.1 | 1.2 | 2.1 | -0.3 | -1.2 | -1.3 | 1.2 | 0.7 | 1.1 | -1.1 | 1.1 | -1.2 | 0.2 | -0.0 | 1.4 | -1.0 | 1.2 | 1.4 | -1.3 | 1.3 | -1.4 | -1.2 |
Context. condit. distance diff. score | 1.1 | 1.3 | 3.2 | -0.3 | -1.1 | -1.3 | 1.1 | 0.0 | 1.3 | -1.3 | 1.0 | -1.1 | 0.7 | 0.0 | 1.5 | -1.0 | 1.1 | 1.4 | -1.1 | 1.6 | -1.8 | -1.1 |
Bouts of movement, locomotor time 1 | 1.1 | 1.2 | 4.6 | 0.4 | 0.7 | 0.7 | -0.8 | 2.2 | -1.8 | 1.6 | 0.1 | 0.7 | -0.1 | 1.1 | -1.2 | 0.9 | -0.5 | -1.0 | 0.8 | -1.1 | 1.8 | 0.7 |
Reaction time mean minus median AUC | 1.0 | 1.3 | 2.7 | -0.1 | 1.1 | 1.3 | -1.1 | -0.3 | -1.2 | 1.2 | -1.1 | 1.2 | -0.4 | 0.3 | -1.6 | 0.8 | -1.1 | -1.6 | 1.1 | -1.5 | 1.6 | 1.1 |
Pavlov. Cond. latency score | 1.0 | 1.3 | 2.8 | -0.6 | 0.9 | 1.5 | -0.9 | -1.1 | -0.8 | 0.9 | -1.5 | 0.9 | 0.3 | -0.9 | -1.7 | 0.7 | -1.1 | -1.7 | 0.9 | -1.6 | 1.3 | 0.9 |
Number of responses in last shaping day | 1.0 | 1.0 | 1.7 | 0.2 | -1.1 | -1.2 | 1.1 | 1.0 | 0.7 | -0.8 | 1.3 | -1.1 | -0.2 | 0.5 | 1.2 | -0.8 | 1.2 | 1.3 | -1.0 | 1.3 | -0.8 | -1.1 |
Delta time to tail flick, vehicle, before/after SA | 1.0 | 1.0 | 1.7 | 1.0 | 1.3 | 1.0 | -1.3 | -0.8 | -0.7 | 0.8 | -1.1 | 1.3 | -1.0 | 0.5 | -0.8 | 1.2 | -1.3 | -0.8 | 1.2 | -0.5 | 0.5 | 1.3 |
Vertical activity count, locomotor time 1 | 1.0 | 1.1 | 1.7 | -0.5 | -1.1 | -1.2 | 1.1 | -0.3 | 1.2 | -1.2 | 0.9 | -1.0 | 0.6 | -0.4 | 1.3 | -1.1 | 1.0 | 1.3 | -1.2 | 1.2 | -1.1 | -1.1 |
Distance moved, locomotor task time 2 | 1.0 | 1.1 | 2.2 | 0.6 | 1.1 | 1.1 | -1.0 | 0.1 | -1.3 | 1.3 | -0.7 | 1.2 | -0.7 | -0.4 | -1.3 | 1.0 | -1.1 | -1.2 | 1.1 | -1.3 | 1.5 | 1.1 |
Condit. Reinf. lever presses | 0.9 | 1.3 | 2.9 | -0.6 | 0.9 | 1.4 | -0.9 | -1.1 | -0.9 | 1.0 | -1.5 | 0.9 | 0.1 | -0.3 | -1.7 | 0.6 | -1.0 | -1.7 | 0.9 | -1.6 | 1.7 | 0.9 |
Pavlov. Cond. response bias | 0.9 | 1.2 | 2.9 | -0.3 | 1.0 | 1.4 | -0.9 | -0.6 | -1.1 | 1.1 | -1.2 | 0.9 | -0.0 | -0.2 | -1.7 | 0.7 | -1.0 | -1.7 | 1.0 | -1.6 | 1.4 | 1.0 |
Conditioned reinforcement - actives | 0.9 | 0.8 | 2.0 | -1.4 | -1.1 | -0.8 | 1.0 | 0.4 | 0.8 | -0.8 | 0.8 | -1.0 | 1.3 | -0.7 | 0.6 | -1.3 | 1.0 | 0.6 | -0.9 | 0.4 | -0.3 | -1.1 |
Locomotion velocity, session 7 | 0.9 | 1.0 | 5.3 | -0.9 | -0.9 | -0.4 | 1.0 | -1.3 | 1.4 | -1.2 | -0.2 | -1.0 | 0.5 | -2.3 | 0.9 | -0.5 | 0.5 | 1.0 | -0.8 | 0.7 | -0.9 | -0.9 |
Pavlov. Cond. intertrial magazine entries | 0.9 | 1.1 | 2.9 | -0.8 | -1.1 | -1.2 | 1.1 | 1.7 | 0.5 | -0.7 | 1.4 | -1.1 | 1.4 | 0.2 | 0.8 | -1.1 | 1.3 | 0.8 | -1.0 | 0.9 | -0.6 | -1.1 |
Bone volume | 0.9 | 1.5 | 4.5 | -1.5 | 0.7 | 1.5 | -0.7 | -2.1 | -0.1 | 0.4 | -1.9 | 0.7 | 0.7 | -1.9 | -1.6 | 0.4 | -1.1 | -1.5 | 0.7 | -1.6 | 0.9 | 0.7 |
Delay disc. indifference point, 16s delay | 0.9 | 0.9 | 1.3 | -0.9 | -1.1 | -1.0 | 1.2 | 0.2 | 1.0 | -1.1 | 0.8 | -1.1 | 1.0 | -0.2 | 0.8 | -1.0 | 1.1 | 0.8 | -1.0 | 1.0 | -0.9 | -1.1 |
Times rat made contact with spout | 0.8 | 0.9 | 1.6 | 1.2 | 1.0 | 0.8 | -1.0 | 0.3 | -1.1 | 1.1 | -0.5 | 1.0 | -0.9 | 1.2 | -0.7 | 1.1 | -0.9 | -0.7 | 1.0 | -0.7 | 0.8 | 1.0 |
Pavlov. Cond. intertrial magazine entries | 0.8 | 1.1 | 1.8 | -0.6 | -0.9 | -1.2 | 1.0 | 0.5 | 1.2 | -1.2 | 1.0 | -1.0 | 1.1 | -0.2 | 1.3 | -1.1 | 0.9 | 1.3 | -1.2 | 1.3 | -1.2 | -0.9 |
Locomotion distance, session 2 | 0.8 | 1.2 | 2.3 | 1.1 | 1.0 | 1.2 | -1.0 | -1.2 | -0.6 | 0.8 | -1.4 | 1.1 | -1.5 | -1.2 | -0.8 | 1.3 | -1.2 | -0.7 | 1.2 | -0.9 | 0.7 | 1.0 |
Bone: trabecular thickness | 0.8 | 1.0 | 1.9 | -1.1 | -1.1 | -0.8 | 1.1 | -0.4 | 1.2 | -1.2 | 0.4 | -1.1 | 1.1 | -0.9 | 0.9 | -1.0 | 0.9 | 0.9 | -1.1 | 0.8 | -1.4 | -1.1 |
Delta time in closed arm before/after self-admin | 0.8 | 0.7 | 3.9 | 1.9 | 0.7 | 0.5 | -0.7 | -0.7 | -0.4 | 0.5 | -0.5 | 0.7 | -2.0 | 0.8 | 0.1 | 1.1 | -0.7 | 0.1 | 0.7 | -0.2 | 0.1 | 0.7 |
Zn content in liver | 0.8 | 0.9 | 1.9 | 0.3 | 1.0 | 1.1 | -1.0 | -0.2 | -1.0 | 1.0 | -0.9 | 0.8 | -0.5 | -0.1 | -1.2 | 1.0 | -1.0 | -1.2 | 0.9 | -1.4 | 1.0 | 1.0 |
Delay discounting total patch changes 6 sec | 0.7 | 1.1 | 1.5 | 0.7 | 1.1 | 1.2 | -1.1 | -0.8 | -1.0 | 1.1 | -1.2 | 1.1 | -0.7 | 0.1 | -1.1 | 1.2 | -1.1 | -1.1 | 1.2 | -1.1 | 1.0 | 1.1 |
Cocaine response after cond. corrected | 0.7 | 0.8 | 2.3 | 0.2 | -0.8 | -1.0 | 0.8 | -0.3 | 1.1 | -1.0 | 0.7 | -0.7 | 0.0 | -0.1 | 1.5 | -0.5 | 0.7 | 1.5 | -0.8 | 1.4 | -1.3 | -0.8 |
Condit. Reinf. inactive responses | 0.7 | 0.9 | 2.1 | 1.4 | 1.1 | 0.8 | -1.0 | 0.0 | -1.0 | 1.0 | -0.6 | 1.0 | -1.5 | 1.0 | -0.7 | 1.2 | -0.9 | -0.7 | 1.0 | -0.6 | 0.4 | 1.1 |
Pavlov. Cond. change in total contacts | 0.7 | 1.0 | 2.9 | -1.3 | 0.5 | 1.1 | -0.5 | -0.6 | -0.7 | 0.7 | -1.1 | 0.5 | 0.9 | -0.9 | -1.7 | 0.2 | -0.6 | -1.7 | 0.6 | -1.6 | 1.6 | 0.5 |
Intermittent access intake escalation 2 | 0.7 | 0.7 | 3.0 | -0.9 | -0.7 | -0.8 | 0.7 | 1.2 | 0.2 | -0.4 | 1.1 | -0.7 | 1.7 | 0.8 | 0.3 | -1.0 | 0.9 | 0.5 | -0.7 | 0.4 | 0.2 | -0.7 |
Locomotion distance, session 1 | 0.7 | 0.9 | 3.1 | 0.7 | 0.8 | 1.1 | -0.8 | -1.8 | -0.2 | 0.4 | -1.5 | 0.8 | -1.0 | -1.0 | -0.6 | 1.1 | -1.1 | -0.6 | 1.0 | -0.7 | 0.6 | 0.8 |
Stereotopy head waving bouts, day 3 | 0.7 | 0.9 | 3.8 | -0.4 | -0.6 | -0.3 | 0.6 | -1.9 | 1.4 | -1.1 | -0.4 | -0.6 | 0.0 | -1.8 | 1.1 | -0.3 | 0.2 | 1.1 | -0.7 | 0.8 | -0.9 | -0.6 |
Stereotopy head waving duration, day 3 | 0.7 | 0.9 | 2.1 | -0.7 | -0.9 | -0.7 | 0.9 | -0.7 | 1.3 | -1.2 | 0.3 | -0.9 | 0.5 | -1.5 | 1.2 | -0.7 | 0.7 | 1.1 | -1.0 | 1.0 | -0.9 | -0.9 |
Bone: elastic displacement | 0.7 | 0.8 | 2.2 | 1.1 | -0.5 | -1.1 | 0.5 | 1.4 | 0.1 | -0.3 | 1.4 | -0.6 | -0.4 | 1.5 | 1.1 | -0.3 | 0.8 | 1.1 | -0.5 | 1.3 | -0.9 | -0.5 |
Sum of active levers in priming session hrs 5-6 | 0.7 | 0.7 | 2.6 | -1.0 | 0.2 | 0.5 | -0.2 | 1.0 | -1.0 | 0.8 | 0.0 | 0.2 | 1.3 | 0.3 | -1.2 | -0.3 | -0.1 | -1.3 | 0.4 | -1.2 | 1.6 | 0.2 |
Time to tail flick, vehicle, before self-admin | 0.7 | 0.7 | 3.3 | -0.3 | 0.7 | 1.0 | -0.6 | -1.8 | -0.1 | 0.3 | -1.3 | 0.6 | -0.1 | -1.1 | -0.8 | 0.5 | -0.9 | -0.8 | 0.6 | -0.9 | 0.9 | 0.7 |
Total resting periods, locomotor time 1 | 0.7 | 0.8 | 3.8 | 0.1 | 0.5 | 0.5 | -0.6 | 2.0 | -1.4 | 1.2 | 0.2 | 0.5 | 0.2 | 0.6 | -1.0 | 0.5 | -0.3 | -0.8 | 0.6 | -0.9 | 1.6 | 0.5 |
Na content in liver | 0.7 | 0.7 | 1.5 | -0.1 | 0.8 | 1.0 | -0.8 | -0.7 | -0.8 | 0.8 | -1.0 | 0.7 | -0.3 | 0.2 | -1.1 | 0.6 | -0.8 | -1.1 | 0.8 | -1.2 | 1.2 | 0.8 |
Left kidney weight | 0.6 | 1.9 | 2.6 | -1.4 | -1.4 | -1.4 | 1.3 | 0.5 | 1.5 | -1.6 | 1.2 | -1.5 | 1.1 | -1.2 | 1.3 | -1.6 | 1.4 | 1.3 | -1.6 | 1.3 | -1.4 | -1.4 |
Reaction time omissions | 0.6 | 0.9 | 3.2 | 0.5 | 0.6 | 1.0 | -0.6 | -0.1 | -1.1 | 1.1 | -0.8 | 0.7 | -1.1 | -0.2 | -1.0 | 0.9 | -0.7 | -1.1 | 0.8 | -1.2 | 1.8 | 0.6 |
Social response proportion | 0.6 | 0.7 | 1.3 | 0.1 | 0.8 | 1.0 | -0.9 | -0.7 | -0.8 | 0.8 | -0.9 | 0.9 | -0.9 | -0.1 | -1.1 | 0.6 | -0.9 | -1.0 | 0.8 | -1.2 | 0.8 | 0.8 |
Post-drug Anxiety | 0.6 | 0.7 | 1.6 | -0.4 | 0.7 | 1.0 | -0.7 | -0.5 | -0.8 | 0.8 | -0.8 | 0.7 | 0.4 | -0.4 | -1.2 | 0.4 | -0.8 | -1.1 | 0.8 | -1.2 | 1.3 | 0.7 |
Time to tail flick, test, before self-admin | 0.6 | 0.6 | 1.5 | -0.1 | -0.6 | -0.4 | 0.6 | -1.1 | 1.2 | -1.0 | -0.2 | -0.6 | -0.2 | -1.2 | 0.9 | -0.2 | 0.3 | 0.9 | -0.6 | 0.9 | -1.1 | -0.6 |
Se content in liver | 0.6 | 0.7 | 3.7 | -1.9 | -0.6 | -0.3 | 0.7 | 0.2 | 0.6 | -0.7 | 0.2 | -0.7 | 1.8 | -1.4 | -0.1 | -1.1 | 0.6 | -0.1 | -0.8 | 0.1 | -0.4 | -0.6 |
Social responses | 0.5 | 0.6 | 1.3 | 0.8 | 1.1 | 0.6 | -1.1 | 0.1 | -0.8 | 0.8 | -0.4 | 1.1 | -0.8 | 0.6 | -0.6 | 0.6 | -0.9 | -0.6 | 0.6 | -0.6 | 0.3 | 1.1 |
Social time | 0.5 | 0.6 | 1.1 | 0.9 | 1.0 | 0.7 | -1.0 | -0.1 | -0.9 | 0.9 | -0.5 | 1.0 | -0.7 | 0.5 | -0.6 | 0.8 | -0.9 | -0.7 | 0.7 | -0.7 | 0.5 | 1.0 |
Cocaine response after cond. not corrected | 0.5 | 0.6 | 1.7 | 0.2 | -0.6 | -0.8 | 0.5 | -0.5 | 1.0 | -0.9 | 0.4 | -0.5 | 0.2 | -0.2 | 1.3 | -0.4 | 0.4 | 1.2 | -0.7 | 1.3 | -1.1 | -0.6 |
Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 2.5 | -1.3 | -0.8 | -0.6 | 0.8 | -0.1 | 0.8 | -0.8 | 0.4 | -0.8 | 1.6 | -0.3 | 0.4 | -0.9 | 0.7 | 0.4 | -0.9 | 0.5 | -0.0 | -0.8 |
Locomotion velocity, session 3 | 0.5 | 0.6 | 3.9 | -0.4 | -0.5 | -0.1 | 0.5 | -2.0 | 1.2 | -0.9 | -0.6 | -0.5 | -0.0 | -1.2 | 0.7 | -0.2 | 0.1 | 0.7 | -0.4 | 0.5 | -0.6 | -0.5 |
Stereotopy head waving bouts, day 7 | 0.5 | 0.6 | 2.0 | -1.4 | -0.9 | -0.4 | 0.9 | -0.3 | 0.9 | -0.8 | 0.2 | -0.8 | 1.0 | -1.1 | 0.3 | -0.9 | 0.7 | 0.3 | -0.8 | 0.3 | -0.3 | -0.9 |
Stereotopy head waving duration, day 7 | 0.5 | 0.6 | 1.5 | -0.7 | 0.5 | 1.0 | -0.5 | -0.7 | -0.5 | 0.6 | -1.1 | 0.6 | 0.2 | -0.8 | -1.2 | 0.5 | -0.7 | -1.2 | 0.6 | -1.2 | 1.0 | 0.5 |
Novel to familiar place preference ratio | 0.5 | 0.6 | 1.5 | -0.9 | 0.5 | 0.8 | -0.5 | -0.4 | -0.5 | 0.6 | -0.8 | 0.5 | 0.5 | -0.6 | -1.2 | 0.2 | -0.5 | -1.2 | 0.4 | -1.2 | 1.2 | 0.5 |
Bone: cortical tissue density | 0.5 | 0.7 | 1.9 | 1.1 | 0.7 | 0.4 | -0.7 | 1.1 | -1.2 | 1.1 | 0.0 | 0.7 | -0.6 | 1.4 | -0.6 | 0.8 | -0.4 | -0.6 | 0.7 | -0.6 | 1.1 | 0.7 |
Bone: periosteal estimation | 0.5 | 1.0 | 4.5 | -2.0 | -0.7 | 0.0 | 0.6 | -1.8 | 1.3 | -1.1 | -0.7 | -0.6 | 1.3 | -2.1 | 0.1 | -0.8 | 0.1 | 0.1 | -0.6 | 0.1 | -0.6 | -0.7 |
Time in open arm before self-admin | 0.5 | 0.5 | 3.9 | 2.0 | 0.2 | -0.4 | -0.2 | 0.2 | -0.1 | 0.1 | 0.4 | 0.2 | -1.7 | 0.7 | 0.8 | 0.7 | -0.0 | 0.8 | 0.1 | 0.8 | -0.0 | 0.2 |
Change in fecal boli incidents, locomotor task | 0.5 | 0.4 | 2.1 | 1.5 | 0.5 | 0.4 | -0.5 | -0.8 | -0.0 | 0.2 | -0.6 | 0.5 | -1.4 | -0.1 | 0.4 | 0.9 | -0.6 | 0.3 | 0.5 | 0.2 | -0.6 | 0.5 |
Food seeking constrained by brief footshock | 0.5 | 0.6 | 2.1 | 1.4 | 0.8 | 0.6 | -0.9 | -0.3 | -0.7 | 0.7 | -0.5 | 0.8 | -1.1 | 0.5 | -0.4 | 0.9 | -0.8 | -0.4 | 0.9 | -0.2 | -0.1 | 0.8 |
Right kidney weight | 0.4 | 1.0 | 3.0 | -1.7 | -1.1 | -1.0 | 1.1 | 0.3 | 1.0 | -1.0 | 0.9 | -1.0 | 1.1 | -0.3 | 0.6 | -1.5 | 1.1 | 0.6 | -1.4 | 0.5 | -0.7 | -1.1 |
Tibia length | 0.4 | 1.2 | 3.5 | -1.5 | 0.6 | 1.2 | -0.7 | -0.4 | -0.9 | 0.9 | -1.0 | 0.7 | 0.9 | -0.5 | -1.9 | -0.0 | -0.8 | -1.9 | 0.7 | -1.8 | 1.6 | 0.6 |
Delay discounting total patch changes 18 sec | 0.4 | 0.5 | 1.1 | -0.2 | 0.8 | 0.8 | -0.8 | -0.2 | -0.6 | 0.6 | -0.8 | 0.6 | 0.2 | -0.1 | -1.0 | 0.5 | -0.8 | -1.0 | 0.7 | -1.0 | 1.0 | 0.8 |
Reaction time num false alarms AUC | 0.4 | 0.6 | 3.4 | 1.9 | 0.7 | 0.3 | -0.7 | 0.3 | -0.7 | 0.7 | -0.2 | 0.6 | -1.6 | 0.3 | 0.1 | 1.1 | -0.6 | 0.1 | 0.6 | -0.0 | 0.1 | 0.7 |
Reaction time trials on left | 0.4 | 0.5 | 0.9 | 0.7 | 0.8 | 0.7 | -0.8 | 0.1 | -0.9 | 0.9 | -0.4 | 0.8 | -0.6 | 0.2 | -0.7 | 0.7 | -0.8 | -0.8 | 0.7 | -0.7 | 0.9 | 0.8 |
Reaction time trials completed | 0.4 | 0.5 | 0.9 | 0.7 | 0.8 | 0.7 | -0.8 | 0.1 | -0.9 | 0.9 | -0.4 | 0.8 | -0.6 | 0.2 | -0.7 | 0.7 | -0.8 | -0.8 | 0.7 | -0.7 | 0.9 | 0.8 |
Cocaine response before conditioning | 0.4 | 0.5 | 1.2 | -0.2 | 0.7 | 0.8 | -0.7 | -0.1 | -0.7 | 0.7 | -0.6 | 0.7 | 0.4 | -0.1 | -1.1 | 0.4 | -0.7 | -1.1 | 0.7 | -0.9 | 1.1 | 0.7 |
Condit. Reinf. inactive responses | 0.4 | 0.5 | 3.4 | -1.0 | -0.6 | -0.1 | 0.6 | -0.9 | 1.0 | -0.9 | -0.4 | -0.6 | 0.7 | -1.8 | 0.4 | -0.5 | 0.2 | 0.4 | -0.5 | 0.2 | -0.5 | -0.6 |
Total zone transitions, hab. session 1 | 0.4 | 0.6 | 1.4 | 0.4 | 0.7 | 0.9 | -0.7 | -0.2 | -0.8 | 0.8 | -0.8 | 0.7 | -0.5 | 0.1 | -0.9 | 0.8 | -0.7 | -0.9 | 0.8 | -1.1 | 1.2 | 0.7 |
Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 1.9 | 1.4 | 0.6 | 0.3 | -0.7 | 0.1 | -0.5 | 0.5 | -0.2 | 0.7 | -1.4 | 0.7 | -0.1 | 0.7 | -0.6 | -0.2 | 0.8 | 0.1 | -0.3 | 0.6 |
Bone: apparent density | 0.4 | 0.7 | 3.5 | -0.6 | 0.5 | 1.0 | -0.5 | -1.9 | 0.2 | 0.1 | -1.5 | 0.5 | -0.1 | -1.6 | -0.8 | 0.5 | -0.9 | -0.7 | 0.5 | -0.7 | -0.1 | 0.5 |
Bone: cortical apparent density | 0.4 | 0.5 | 1.6 | 0.9 | 0.6 | 0.4 | -0.6 | 1.0 | -1.1 | 0.9 | 0.1 | 0.6 | -0.5 | 1.3 | -0.5 | 0.7 | -0.3 | -0.5 | 0.6 | -0.5 | 1.0 | 0.6 |
Bone: cortical porosity | 0.4 | 0.4 | 0.7 | 0.2 | 0.7 | 0.9 | -0.7 | -0.1 | -0.6 | 0.7 | -0.8 | 0.7 | -0.5 | -0.1 | -0.7 | 0.8 | -0.8 | -0.7 | 0.7 | -0.8 | 0.6 | 0.7 |
Bone: trabecular number | 0.4 | 0.6 | 3.0 | -1.1 | 0.3 | 0.8 | -0.3 | -1.5 | 0.2 | -0.0 | -1.2 | 0.3 | 0.4 | -1.7 | -0.9 | 0.1 | -0.6 | -0.8 | 0.3 | -0.9 | 0.1 | 0.3 |
Diff in mean of infusions in LGA sessions | 0.4 | 0.4 | 0.9 | 0.6 | 0.6 | 0.5 | -0.6 | 0.4 | -0.9 | 0.8 | -0.2 | 0.6 | -0.1 | 1.0 | -0.9 | 0.5 | -0.5 | -0.9 | 0.8 | -0.6 | 0.8 | 0.6 |
Ambulatory time after self-admin | 0.4 | 0.5 | 1.8 | -1.3 | -0.8 | -0.5 | 0.8 | 0.4 | 0.7 | -0.7 | 0.4 | -0.7 | 1.2 | -0.5 | 0.3 | -0.9 | 0.7 | 0.3 | -0.7 | 0.4 | -0.4 | -0.8 |
Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 1.9 | 1.4 | 0.7 | 0.2 | -0.6 | -0.9 | -0.0 | 0.1 | -0.5 | 0.6 | -1.0 | 1.0 | 0.1 | 0.7 | -0.6 | 0.1 | 0.5 | 0.2 | -0.2 | 0.7 |
Bouts of movement, locomotor time 2 | 0.4 | 0.4 | 1.0 | 0.5 | 0.5 | 0.5 | -0.6 | 0.5 | -1.0 | 0.9 | -0.1 | 0.5 | -0.2 | 1.0 | -0.7 | 0.7 | -0.4 | -0.8 | 0.6 | -0.6 | 0.8 | 0.5 |
Run reversals in cocaine runway, males | 0.4 | 0.3 | 4.2 | 0.3 | 0.1 | -0.5 | -0.1 | 0.4 | 0.1 | -0.2 | 0.7 | 0.1 | 0.1 | 2.1 | 0.4 | -0.4 | 0.2 | 0.4 | -0.2 | 0.6 | -0.6 | 0.1 |
Std. dev. time between licks in bursts | 0.3 | 0.4 | 2.3 | 1.5 | 0.3 | 0.0 | -0.3 | 0.3 | -0.3 | 0.3 | 0.1 | 0.4 | -1.2 | 1.0 | 0.3 | 0.7 | -0.3 | 0.4 | 0.4 | 0.5 | -0.3 | 0.3 |
Reaction time number correct | 0.3 | 0.4 | 0.7 | 0.7 | 0.8 | 0.6 | -0.7 | 0.0 | -0.8 | 0.8 | -0.3 | 0.7 | -0.6 | 0.2 | -0.6 | 0.6 | -0.7 | -0.7 | 0.6 | -0.6 | 0.8 | 0.8 |
Reaction time trials correct on left | 0.3 | 0.4 | 0.7 | 0.7 | 0.8 | 0.6 | -0.7 | 0.0 | -0.8 | 0.8 | -0.3 | 0.7 | -0.6 | 0.2 | -0.6 | 0.6 | -0.7 | -0.7 | 0.6 | -0.6 | 0.8 | 0.8 |
Median of all reaction times | 0.3 | 0.4 | 0.9 | -1.0 | -0.8 | -0.6 | 0.8 | 0.2 | 0.5 | -0.5 | 0.5 | -0.8 | 0.7 | -0.2 | 0.4 | -0.7 | 0.8 | 0.3 | -0.7 | 0.3 | -0.2 | -0.8 |
Std. dev. reaction times | 0.3 | 0.4 | 1.4 | -0.6 | 0.3 | 0.7 | -0.3 | -0.1 | -0.7 | 0.7 | -0.6 | 0.4 | 0.1 | -0.3 | -1.1 | 0.3 | -0.4 | -1.1 | 0.5 | -1.1 | 1.2 | 0.3 |
Locomotion distance, session 8 | 0.3 | 0.4 | 2.3 | -0.4 | -0.4 | -0.1 | 0.4 | -1.5 | 1.0 | -0.8 | -0.5 | -0.4 | 0.2 | -1.4 | 0.5 | -0.2 | 0.0 | 0.5 | -0.3 | 0.5 | -0.7 | -0.4 |
Incentive salience index mean | 0.3 | 0.4 | 0.9 | 0.3 | 0.7 | 0.8 | -0.7 | -0.6 | -0.3 | 0.4 | -0.9 | 0.7 | -0.1 | -0.4 | -0.4 | 0.7 | -0.8 | -0.5 | 0.5 | -0.6 | 0.7 | 0.7 |
Condit. Reinf. lever presses | 0.3 | 0.4 | 1.1 | -0.3 | 0.5 | 0.8 | -0.5 | -1.0 | 0.0 | 0.1 | -1.0 | 0.5 | -0.0 | -1.0 | -0.5 | 0.4 | -0.7 | -0.5 | 0.4 | -0.6 | 0.6 | 0.5 |
Time in familiar zone, hab. session 1 | 0.3 | 0.3 | 0.5 | -0.5 | -0.5 | -0.4 | 0.5 | -0.3 | 0.7 | -0.7 | 0.1 | -0.5 | -0.1 | -0.7 | 0.6 | -0.4 | 0.4 | 0.6 | -0.5 | 0.5 | -0.7 | -0.5 |
Total locomotion distance, hab. session 1 | 0.3 | 0.4 | 1.1 | -0.6 | -0.7 | -0.4 | 0.7 | -0.7 | 1.0 | -0.9 | 0.0 | -0.7 | 0.3 | -0.8 | 0.7 | -0.6 | 0.4 | 0.7 | -0.7 | 0.6 | -0.5 | -0.7 |
Total locomotion distance, hab. session 2 | 0.3 | 0.4 | 2.1 | 0.0 | 0.2 | 0.4 | -0.2 | -1.4 | 0.6 | -0.4 | -1.0 | 0.1 | -0.7 | -1.5 | 0.2 | 0.4 | -0.5 | 0.2 | 0.1 | 0.0 | -0.2 | 0.2 |
Locomotion velocity, hab. session 2 | 0.3 | 0.4 | 3.2 | -0.4 | -0.2 | 0.1 | 0.2 | -1.4 | 1.0 | -0.7 | -0.8 | -0.2 | -0.3 | -1.8 | 0.4 | -0.0 | -0.2 | 0.4 | -0.3 | 0.2 | -0.4 | -0.2 |
Novelty place preference | 0.3 | 0.3 | 0.9 | -0.9 | 0.2 | 0.5 | -0.2 | -0.2 | -0.3 | 0.3 | -0.4 | 0.3 | 0.8 | -0.5 | -0.8 | -0.1 | -0.2 | -0.7 | 0.1 | -0.8 | 0.8 | 0.2 |
Pavlov. Cond. lever latency | 0.3 | 0.4 | 0.9 | 0.0 | -0.6 | -0.8 | 0.6 | 0.8 | 0.2 | -0.3 | 0.9 | -0.7 | 0.2 | 0.8 | 0.6 | -0.5 | 0.8 | 0.6 | -0.5 | 0.6 | -0.6 | -0.6 |
Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.3 | 0.6 | -0.2 | 0.6 | 0.7 | -0.6 | -0.2 | -0.5 | 0.5 | -0.7 | 0.6 | -0.0 | -0.3 | -0.7 | 0.4 | -0.6 | -0.8 | 0.4 | -0.7 | 0.8 | 0.6 |
Bone: cortical area | 0.3 | 0.5 | 1.2 | -0.5 | 0.6 | 0.9 | -0.6 | -0.6 | -0.5 | 0.6 | -0.9 | 0.6 | 0.2 | -0.5 | -1.1 | 0.3 | -0.7 | -1.0 | 0.6 | -0.9 | 0.7 | 0.6 |
Bone: maximum diameter | 0.3 | 0.5 | 2.9 | -1.7 | -0.2 | 0.4 | 0.2 | -1.0 | 0.4 | -0.3 | -0.6 | -0.1 | 1.3 | -1.3 | -0.6 | -0.6 | -0.1 | -0.6 | -0.2 | -0.5 | 0.2 | -0.2 |
Bone: periosteal perimeter | 0.3 | 0.5 | 2.3 | -1.5 | -0.3 | 0.3 | 0.3 | -1.4 | 0.6 | -0.5 | -0.7 | -0.2 | 0.9 | -1.4 | -0.3 | -0.4 | -0.1 | -0.2 | -0.3 | -0.4 | -0.1 | -0.3 |
Distance traveled before self-admin | 0.3 | 0.3 | 0.7 | -0.7 | 0.3 | 0.6 | -0.3 | -0.4 | -0.4 | 0.4 | -0.6 | 0.3 | 0.5 | -0.2 | -0.8 | 0.1 | -0.4 | -0.8 | 0.3 | -0.9 | 0.7 | 0.3 |
Delta time in open arm before/after self-admin | 0.3 | 0.3 | 2.0 | -1.1 | -0.0 | -0.1 | 0.0 | 0.7 | -0.2 | 0.1 | 0.3 | 0.0 | 1.4 | 0.5 | -0.5 | -0.6 | 0.1 | -0.4 | -0.2 | -0.2 | 0.0 | -0.0 |
Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 2.4 | 0.8 | 0.3 | 0.1 | -0.1 | -1.5 | 0.5 | -0.3 | -0.6 | 0.2 | -0.8 | 0.5 | 0.3 | 0.4 | -0.3 | 0.3 | 0.3 | 0.4 | -0.6 | 0.3 |
Delay disc. indifference point, 24s delay | 0.3 | 0.3 | 1.5 | 1.2 | 0.4 | 0.0 | -0.4 | 0.4 | -0.4 | 0.4 | 0.2 | 0.3 | -0.7 | 1.2 | 0.1 | 0.5 | -0.2 | 0.1 | 0.4 | 0.2 | 0.2 | 0.4 |
Delay disc. indifference point, 8s delay | 0.3 | 0.3 | 1.0 | 0.9 | 0.3 | 0.3 | -0.4 | -0.8 | -0.1 | 0.2 | -0.4 | 0.5 | -0.9 | 1.0 | 0.0 | 0.7 | -0.5 | 0.0 | 0.5 | 0.0 | -0.1 | 0.3 |
Fecal boli incidents, locomotor time 1 | 0.3 | 0.3 | 2.1 | -1.4 | -0.2 | -0.0 | 0.2 | -0.3 | 0.3 | -0.3 | -0.1 | -0.3 | 1.2 | -0.6 | -0.5 | -0.7 | 0.2 | -0.5 | -0.3 | -0.3 | 0.2 | -0.2 |
Distance moved, locomotor task time 1 | 0.3 | 0.4 | 1.8 | 0.0 | 0.4 | 0.5 | -0.4 | -1.3 | 0.1 | 0.1 | -0.9 | 0.5 | -0.3 | -1.3 | -0.4 | 0.4 | -0.7 | -0.4 | 0.4 | -0.4 | 0.2 | 0.4 |
Mg content in liver | 0.3 | 0.3 | 1.7 | -0.3 | 0.1 | 0.5 | -0.1 | -1.3 | 0.4 | -0.2 | -1.0 | 0.1 | -0.1 | -1.3 | -0.1 | 0.4 | -0.5 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 |
Light reinforcement 1 | 0.2 | 0.3 | 1.3 | 0.2 | -0.3 | -0.6 | 0.2 | 0.9 | -0.0 | -0.1 | 0.8 | -0.3 | 0.9 | 1.2 | 0.5 | -0.3 | 0.6 | 0.4 | -0.5 | 0.4 | -0.5 | -0.3 |
Reaction time num false alarms | 0.2 | 0.3 | 2.3 | 1.5 | 0.0 | -0.3 | 0.0 | 0.5 | -0.0 | 0.0 | 0.4 | -0.1 | -1.2 | 0.2 | 0.7 | 0.5 | 0.1 | 0.8 | 0.0 | 0.7 | -0.5 | 0.0 |
Reaction time mean AUC | 0.2 | 0.2 | 1.0 | -1.0 | -0.5 | -0.2 | 0.5 | 0.2 | 0.2 | -0.2 | 0.2 | -0.5 | 0.8 | -0.2 | -0.0 | -0.5 | 0.5 | -0.1 | -0.4 | -0.1 | 0.3 | -0.5 |
Reaction time false alarm rate | 0.2 | 0.2 | 1.4 | 1.2 | 0.0 | -0.2 | -0.0 | 0.2 | 0.1 | -0.1 | 0.2 | -0.0 | -0.9 | 0.1 | 0.7 | 0.4 | 0.0 | 0.7 | 0.1 | 0.6 | -0.7 | 0.0 |
Reaction time trials AUC | 0.2 | 0.3 | 0.5 | 0.7 | 0.7 | 0.5 | -0.7 | -0.0 | -0.7 | 0.7 | -0.3 | 0.6 | -0.6 | 0.2 | -0.5 | 0.6 | -0.6 | -0.6 | 0.6 | -0.5 | 0.7 | 0.7 |
Pavlov. Cond. lever latency | 0.2 | 0.3 | 0.8 | 0.8 | -0.3 | -0.7 | 0.3 | 0.9 | 0.1 | -0.2 | 0.8 | -0.3 | -0.5 | 0.8 | 0.8 | -0.1 | 0.4 | 0.8 | -0.2 | 0.7 | -0.6 | -0.3 |
Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.7 | -0.6 | 0.3 | 0.6 | -0.3 | -0.2 | -0.4 | 0.4 | -0.5 | 0.3 | 0.5 | -0.3 | -0.8 | 0.0 | -0.3 | -0.8 | 0.3 | -0.8 | 0.6 | 0.3 |
Locomotion velocity, session 1 | 0.2 | 0.3 | 0.8 | 0.9 | 0.5 | 0.3 | -0.5 | -0.7 | -0.3 | 0.3 | -0.4 | 0.4 | -0.9 | 0.7 | -0.0 | 0.5 | -0.4 | -0.1 | 0.4 | -0.2 | 0.3 | 0.5 |
Locomotion distance, session 7 | 0.2 | 0.2 | 1.1 | 0.5 | -0.0 | 0.1 | 0.0 | -1.0 | 0.5 | -0.3 | -0.4 | -0.0 | -0.6 | -1.0 | 0.5 | 0.3 | -0.2 | 0.5 | 0.0 | 0.3 | -0.4 | -0.0 |
Degree of sensitization distance | 0.2 | 0.2 | 1.8 | -0.1 | -0.1 | 0.2 | 0.1 | -1.2 | 0.6 | -0.4 | -0.6 | -0.1 | -0.2 | -1.3 | 0.4 | 0.2 | -0.2 | 0.4 | -0.1 | 0.1 | -0.3 | -0.1 |
Degree of sensitization stereotypy | 0.2 | 0.3 | 1.2 | -1.1 | -0.1 | 0.4 | 0.1 | -0.4 | -0.1 | 0.1 | -0.5 | -0.0 | 0.5 | -0.6 | -0.8 | -0.1 | -0.0 | -0.8 | 0.1 | -0.8 | 0.7 | -0.1 |
Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.4 | 0.4 | 0.5 | 0.4 | -0.5 | -0.0 | -0.4 | 0.4 | -0.4 | 0.5 | 0.0 | 0.2 | -0.3 | 0.6 | -0.5 | -0.3 | 0.4 | -0.4 | 0.6 | 0.5 |
Time in novel zone, hab. session 1 | 0.2 | 0.2 | 1.2 | 1.0 | 0.1 | -0.3 | -0.1 | 0.3 | -0.2 | 0.1 | 0.4 | 0.1 | -0.4 | 1.1 | 0.3 | 0.1 | 0.1 | 0.4 | 0.1 | 0.4 | -0.2 | 0.1 |
Time in novel zone, NPP test | 0.2 | 0.2 | 0.6 | -0.7 | 0.2 | 0.4 | -0.2 | -0.3 | -0.2 | 0.2 | -0.4 | 0.3 | 0.7 | -0.3 | -0.7 | -0.0 | -0.2 | -0.6 | 0.1 | -0.7 | 0.6 | 0.2 |
Pavlov. Cond. magazine entry latency | 0.2 | 0.3 | 0.7 | -0.3 | 0.4 | 0.6 | -0.4 | -0.9 | -0.1 | 0.2 | -0.8 | 0.4 | 0.1 | -0.5 | -0.5 | 0.4 | -0.6 | -0.6 | 0.3 | -0.5 | 0.6 | 0.4 |
Pavlov. Cond. change in total contacts | 0.2 | 0.2 | 1.2 | -1.1 | -0.3 | -0.0 | 0.3 | -0.0 | 0.3 | -0.3 | -0.1 | -0.3 | 1.0 | -1.0 | -0.2 | -0.4 | 0.2 | -0.2 | -0.4 | -0.3 | 0.4 | -0.3 |
Bone: trabecular spacing | 0.2 | 0.3 | 1.3 | 1.1 | 0.0 | -0.4 | -0.0 | 1.1 | -0.2 | 0.1 | 0.6 | -0.0 | -0.6 | 1.0 | 0.6 | 0.2 | 0.2 | 0.6 | -0.0 | 0.5 | -0.0 | 0.0 |
Delta ambulatory time before/after self-admin | 0.2 | 0.2 | 1.0 | 1.0 | 0.2 | -0.0 | -0.3 | 0.3 | -0.3 | 0.3 | 0.1 | 0.3 | -0.9 | 0.9 | 0.1 | 0.4 | -0.1 | 0.1 | 0.3 | 0.2 | 0.0 | 0.2 |
Time in closed arm before self-admin | 0.2 | 0.2 | 1.2 | -1.1 | -0.2 | 0.1 | 0.2 | -0.1 | 0.3 | -0.2 | -0.2 | -0.1 | 1.0 | -0.8 | -0.2 | -0.4 | 0.0 | -0.2 | -0.2 | -0.2 | -0.2 | -0.2 |
Time in open arm after self-admin | 0.2 | 0.2 | 1.4 | 0.4 | 0.0 | -0.5 | -0.0 | 1.2 | -0.4 | 0.2 | 0.9 | -0.0 | 0.0 | 1.0 | 0.2 | -0.1 | 0.3 | 0.2 | -0.1 | 0.4 | -0.0 | 0.0 |
Ambulatory time before self-admin | 0.2 | 0.3 | 1.6 | -1.3 | -0.1 | 0.3 | 0.1 | -0.2 | -0.1 | 0.1 | -0.3 | -0.1 | 1.1 | -0.5 | -0.6 | -0.3 | -0.1 | -0.6 | -0.0 | -0.6 | 0.4 | -0.1 |
Delay discount exponential model param | 0.2 | 0.2 | 0.5 | -0.6 | -0.3 | -0.2 | 0.4 | 0.7 | 0.0 | -0.1 | 0.4 | -0.4 | 0.5 | -0.7 | 0.1 | -0.5 | 0.4 | 0.1 | -0.4 | 0.0 | -0.2 | -0.3 |
Delay discount hyperbolic model param | 0.2 | 0.2 | 0.8 | -0.6 | -0.4 | -0.3 | 0.4 | 0.9 | 0.0 | -0.1 | 0.5 | -0.5 | 0.5 | -0.7 | 0.1 | -0.5 | 0.5 | 0.1 | -0.4 | 0.1 | -0.3 | -0.4 |
Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.8 | -0.9 | -0.4 | -0.1 | 0.4 | 0.5 | 0.1 | -0.1 | 0.1 | -0.4 | 0.9 | -0.3 | -0.2 | -0.4 | 0.3 | -0.1 | -0.3 | -0.4 | 0.1 | -0.4 |
Total resting periods, locomotor time 2 | 0.2 | 0.2 | 0.9 | 0.3 | 0.3 | 0.2 | -0.4 | 0.4 | -0.6 | 0.5 | -0.0 | 0.3 | -0.0 | 0.9 | -0.4 | 0.4 | -0.2 | -0.6 | 0.3 | -0.3 | 0.4 | 0.3 |
Vertical activity count, locomotor time 2 | 0.2 | 0.3 | 1.4 | 1.2 | 0.4 | -0.1 | -0.3 | 0.9 | -0.6 | 0.5 | 0.5 | 0.4 | -0.8 | 0.4 | 0.1 | 0.3 | -0.2 | 0.2 | 0.3 | 0.0 | 0.3 | 0.4 |
Latency to leave start box in cocaine runway | 0.2 | 0.3 | 1.0 | -0.8 | -0.3 | -0.0 | 0.5 | -0.9 | 0.7 | -0.6 | -0.4 | -0.5 | 0.3 | -1.0 | 0.2 | -0.2 | 0.2 | 0.2 | -0.3 | 0.1 | -0.6 | -0.3 |
Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 1.2 | -0.5 | -0.4 | 0.0 | 0.4 | -1.1 | 0.7 | -0.5 | -0.4 | -0.4 | 0.1 | -0.6 | 0.3 | -0.2 | 0.1 | 0.1 | -0.2 | 0.3 | -0.7 | -0.4 |
Cu content in liver | 0.2 | 0.3 | 0.4 | 0.4 | 0.6 | 0.5 | -0.6 | 0.6 | -0.7 | 0.6 | -0.3 | 0.6 | -0.3 | 0.1 | -0.6 | 0.6 | -0.5 | -0.6 | 0.5 | -0.6 | 0.2 | 0.6 |
Liver weight, left | 0.1 | 0.1 | 1.3 | -0.3 | -0.2 | -0.1 | 0.2 | -1.2 | 0.5 | -0.4 | -0.2 | -0.1 | 0.0 | 0.3 | 0.3 | -0.2 | 0.1 | 0.3 | -0.2 | 0.2 | -0.5 | -0.2 |
Liver weight, right | 0.1 | 0.2 | 2.3 | 0.4 | 0.2 | 0.2 | -0.2 | -1.5 | 0.4 | -0.2 | -0.6 | 0.3 | -0.6 | 0.0 | 0.1 | 0.3 | -0.4 | 0.1 | 0.3 | 0.2 | -0.4 | 0.2 |
Number of licking bursts | 0.1 | 0.1 | 0.4 | -0.1 | 0.3 | 0.4 | -0.3 | -0.1 | -0.4 | 0.4 | -0.4 | 0.3 | -0.3 | -0.1 | -0.5 | 0.3 | -0.3 | -0.5 | 0.3 | -0.7 | 0.5 | 0.3 |
Food consumed during 24 hour testing period | 0.1 | 0.1 | 0.9 | -0.3 | -0.1 | -0.2 | 0.1 | 0.9 | -0.4 | 0.2 | 0.5 | -0.1 | 0.7 | 0.4 | -0.2 | -0.4 | 0.3 | -0.2 | -0.2 | -0.3 | 0.2 | -0.1 |
Mean num. licks in bursts | 0.1 | 0.1 | 0.5 | 0.6 | -0.0 | -0.3 | 0.0 | 0.5 | -0.1 | 0.0 | 0.4 | -0.1 | -0.0 | 0.7 | 0.4 | 0.1 | 0.2 | 0.4 | -0.0 | 0.5 | -0.3 | -0.0 |
Indifference point 0 sec | 0.1 | 0.1 | 0.3 | -0.3 | -0.3 | -0.3 | 0.3 | 0.5 | 0.2 | -0.3 | 0.3 | -0.4 | 0.6 | -0.5 | 0.4 | -0.3 | 0.4 | 0.3 | -0.4 | 0.2 | -0.2 | -0.3 |
Reaction time mean | 0.1 | 0.2 | 0.8 | -0.9 | -0.4 | -0.2 | 0.4 | 0.2 | 0.1 | -0.1 | 0.2 | -0.4 | 0.7 | -0.1 | -0.1 | -0.5 | 0.4 | -0.2 | -0.4 | -0.2 | 0.3 | -0.4 |
Condit. Reinf. lever reinforcers received | 0.1 | 0.1 | 0.6 | -0.4 | 0.2 | 0.3 | -0.2 | -0.0 | -0.3 | 0.3 | -0.3 | 0.2 | 0.5 | 0.3 | -0.5 | 0.0 | -0.2 | -0.5 | 0.1 | -0.5 | 0.8 | 0.2 |
Cocaine induced anxiety | 0.1 | 0.1 | 0.6 | -0.8 | -0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -0.0 | -0.1 | 0.7 | -0.3 | -0.1 | -0.4 | 0.1 | -0.0 | -0.1 | -0.1 | 0.1 | -0.1 |
Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.6 | 0.4 | 0.3 | 0.0 | -0.3 | 0.8 | -0.5 | 0.4 | 0.2 | 0.3 | 0.2 | 0.8 | -0.1 | 0.3 | -0.1 | -0.1 | 0.1 | -0.1 | 0.4 | 0.3 |
Condit. Reinf. active responses | 0.1 | 0.1 | 0.5 | -0.3 | 0.0 | 0.2 | 0.0 | -0.2 | 0.2 | -0.2 | -0.3 | 0.0 | 0.5 | -0.7 | 0.0 | 0.0 | -0.1 | 0.0 | -0.1 | -0.1 | 0.2 | 0.0 |
Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.4 | -0.3 | -0.2 | -0.0 | 0.2 | -0.4 | 0.5 | -0.4 | -0.3 | -0.2 | 0.0 | -0.6 | 0.2 | -0.1 | 0.0 | 0.2 | -0.2 | 0.1 | -0.0 | -0.2 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.6 | -0.6 | -0.1 | 0.0 | 0.1 | -0.2 | 0.1 | -0.1 | -0.1 | -0.2 | 0.8 | -0.3 | -0.1 | -0.1 | 0.1 | -0.0 | -0.2 | -0.2 | 0.5 | -0.1 |
Total locomotion distance, NPP test | 0.1 | 0.2 | 1.4 | 0.2 | 0.2 | 0.4 | -0.2 | -1.2 | 0.3 | -0.1 | -0.8 | 0.2 | -0.7 | -0.7 | -0.0 | 0.4 | -0.4 | 0.0 | 0.2 | -0.2 | 0.1 | 0.2 |
Locomotion velocity, NPP test | 0.1 | 0.1 | 0.7 | 0.1 | 0.2 | 0.4 | -0.1 | -0.8 | 0.2 | -0.0 | -0.7 | 0.2 | -0.6 | -0.6 | -0.1 | 0.3 | -0.3 | -0.1 | 0.2 | -0.3 | 0.3 | 0.2 |
Pavlov. Cond. index score | 0.1 | 0.1 | 0.3 | -0.2 | 0.4 | 0.4 | -0.4 | -0.0 | -0.3 | 0.3 | -0.4 | 0.4 | 0.1 | -0.3 | -0.5 | 0.2 | -0.4 | -0.6 | 0.2 | -0.5 | 0.6 | 0.4 |
Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | -0.1 | 0.4 | 0.4 | -0.4 | -0.3 | -0.1 | 0.2 | -0.5 | 0.4 | 0.0 | -0.4 | -0.4 | 0.2 | -0.4 | -0.4 | 0.2 | -0.3 | 0.3 | 0.4 |
Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.2 | 0.1 | 0.4 | 0.3 | -0.4 | -0.4 | 0.0 | 0.1 | -0.5 | 0.4 | -0.3 | -0.3 | -0.1 | 0.3 | -0.5 | -0.1 | 0.2 | -0.1 | 0.2 | 0.4 |
Pavlov. Cond. magazine entry number | 0.1 | 0.2 | 0.6 | 0.4 | -0.3 | -0.3 | 0.3 | -0.4 | 0.5 | -0.4 | 0.1 | -0.3 | -0.4 | -0.2 | 0.7 | -0.0 | 0.2 | 0.7 | -0.1 | 0.6 | -0.7 | -0.3 |
Pavlov. Cond. response bias | 0.1 | 0.1 | 0.4 | -0.3 | 0.2 | 0.2 | -0.3 | 0.2 | -0.3 | 0.2 | -0.1 | 0.3 | 0.2 | 0.1 | -0.3 | 0.0 | -0.2 | -0.4 | 0.0 | -0.4 | 0.6 | 0.2 |
Bone: tissue strength | 0.1 | 0.1 | 0.8 | -0.6 | -0.3 | -0.1 | 0.3 | 0.2 | 0.2 | -0.2 | 0.1 | -0.3 | 0.5 | -0.9 | 0.0 | -0.3 | 0.2 | 0.0 | -0.3 | 0.1 | 0.1 | -0.3 |
Distance traveled after self-admin | 0.1 | 0.1 | 0.4 | -0.5 | 0.0 | 0.2 | -0.0 | 0.6 | -0.3 | 0.3 | 0.0 | 0.1 | 0.4 | 0.1 | -0.4 | -0.1 | 0.0 | -0.4 | 0.1 | -0.4 | 0.4 | 0.0 |
Delta distance traveled before/after self-admin | 0.1 | 0.1 | 0.5 | 0.6 | 0.0 | -0.2 | -0.0 | 0.5 | -0.1 | 0.1 | 0.3 | 0.1 | -0.6 | 0.7 | 0.2 | 0.1 | 0.1 | 0.3 | 0.1 | 0.3 | -0.2 | 0.0 |
Time in closed arm after self-admin | 0.1 | 0.1 | 0.5 | 0.6 | -0.2 | -0.1 | 0.2 | -0.3 | 0.3 | -0.2 | -0.1 | -0.1 | -0.7 | -0.3 | 0.4 | 0.2 | -0.0 | 0.5 | -0.1 | 0.2 | -0.4 | -0.2 |
Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.9 | 0.1 | 0.4 | 0.2 | -0.4 | -0.1 | -0.2 | 0.2 | -0.1 | 0.4 | 0.0 | 0.0 | -0.1 | 0.1 | -0.3 | -0.2 | 0.1 | -0.0 | 0.9 | 0.4 |
Area under the delay curve | 0.1 | 0.1 | 0.8 | 0.5 | 0.3 | 0.2 | -0.3 | -0.9 | 0.1 | -0.0 | -0.5 | 0.3 | -0.5 | 0.6 | -0.0 | 0.4 | -0.4 | -0.0 | 0.3 | 0.0 | 0.1 | 0.3 |
Delay disc. indifference point, 2s delay | 0.1 | 0.1 | 0.7 | -0.2 | 0.1 | 0.0 | 0.0 | -0.9 | 0.5 | -0.4 | -0.3 | 0.0 | 0.0 | -0.4 | 0.1 | -0.1 | -0.1 | 0.1 | -0.0 | 0.1 | 0.0 | 0.1 |
Seeking ratio, delayed vs. immediate footshock | 0.1 | 0.1 | 0.6 | 0.2 | 0.0 | -0.3 | 0.0 | 0.6 | 0.2 | -0.2 | 0.2 | -0.0 | -0.1 | -0.8 | 0.4 | 0.1 | -0.0 | 0.4 | -0.3 | 0.3 | -0.2 | 0.0 |
Fe content in liver | 0.1 | 0.2 | 0.6 | -0.5 | 0.3 | 0.4 | -0.2 | -0.7 | -0.1 | 0.2 | -0.5 | 0.3 | 0.4 | -0.3 | -0.6 | 0.0 | -0.3 | -0.6 | 0.3 | -0.4 | 0.5 | 0.3 |
Delay discounting total patch changes 0 sec | 0.0 | 0.1 | 0.4 | 0.2 | -0.1 | -0.2 | 0.1 | 0.6 | -0.1 | 0.0 | 0.4 | -0.2 | 0.2 | -0.1 | 0.3 | -0.0 | 0.2 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 |
Condit. Reinf. active responses | 0.0 | 0.0 | 0.3 | -0.5 | -0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.5 | 0.2 | -0.2 | -0.2 | 0.1 | -0.1 | -0.2 | -0.0 | 0.3 | -0.1 |
Locomotion distance, session 3 | 0.0 | 0.0 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | -0.4 | 0.2 | -0.2 | -0.1 | -0.1 | -0.2 | 0.1 | 0.2 | -0.0 | 0.0 | 0.2 | -0.0 | 0.3 | -0.2 | -0.1 |
Bone: cortical porosity | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | 0.3 | -0.1 | 0.1 | -0.1 | 0.1 | -0.3 | 0.1 | -0.2 | -0.4 | -0.1 | 0.2 | -0.2 | -0.2 | 0.1 | -0.3 | 0.1 | 0.1 |
Latency to leave start box in cocaine runway, F | 0.0 | 0.0 | 0.2 | -0.5 | 0.1 | 0.1 | 0.1 | -0.3 | 0.1 | -0.1 | -0.2 | -0.1 | 0.2 | -0.4 | -0.1 | -0.0 | 0.0 | -0.1 | 0.0 | -0.2 | -0.0 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.