Hub : Genes

Krt71

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression ENSRNOG00000049495 0.21 0.13 4.9e-04 0.14 0.11 0.08 0.12 4.2e-04 1.6e-03 5.7e-03 7.4e-04
2 Liver gene expression ENSRNOG00000049495 0.23 0.11 3.1e-13 0.1 0.1 0.11 0.1 1.7e-11 1.4e-11 6.6e-12 2.0e-11
3 NAcc gene expression ENSRNOG00000049495 0.13 0.06 3.5e-13 0.11 0.17 0.17 0.16 1.2e-08 1.3e-12 2.0e-12 5.7e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.37.411.9-1.7-3.42.7
BMI without tail0.40.92.2-0.2-1.50.7
Body weight0.41.83.4-0.3-1.81.3
Epididymis fat weight3.48.011.53.42.0-2.9
Glucose0.20.30.60.80.1-0.6
Heart weight0.00.00.0-0.1-0.1-0.0
Left kidney weight0.00.10.3-0.1-0.20.5
Right kidney weight0.20.71.1-0.4-0.81.1
Tail length0.41.31.61.11.2-1.1
Length with tail0.20.81.11.00.9-0.7
Length without tail0.00.10.10.1-0.20.3
Liver weight, left0.00.00.10.00.4-0.1
Liver weight, right0.10.10.2-0.10.5-0.2
Parametrial fat weight4.07.811.62.33.4-2.5
Retroperitoneal fat weight2.06.67.42.42.7-2.5
Intraocular pressure0.60.82.2-0.01.5-0.5
Extensor digitorum longus weight7.831.342.8-4.4-6.55.6
Soleus weight0.20.41.20.3-1.10.3
Tibialis anterior weight10.034.441.4-5.0-6.46.1
Tibia length0.00.10.2-0.0-0.10.4
Number of licking bursts0.20.30.5-0.70.40.4
Food consumed during 24 hour testing period0.50.60.90.71.0-0.7
Times rat made contact with spout0.40.50.80.60.9-0.6
Mean time between licks in bursts0.81.11.40.90.9-1.2
Mean num. licks in bursts0.81.01.81.30.3-1.0
Std. dev. time between licks in bursts1.41.61.91.21.2-1.4
Water consumed over 24 hours0.40.40.50.60.6-0.7
Indifference point 0 sec0.40.61.50.01.2-0.6
Indifference point AUC0.20.20.5-0.7-0.00.5
Indifference point function ln k0.30.41.00.4-1.00.2
Indifference point function log k0.30.41.00.4-1.00.2
Delay discounting total patch changes 0 sec0.81.32.40.51.6-1.1
Delay discounting total patch changes 12 sec0.70.92.4-0.41.5-0.3
Delay discounting total patch changes 18 sec0.81.12.8-0.21.7-0.6
Delay discounting total patch changes 24 sec0.30.30.8-0.90.40.2
Delay discounting total patch changes 6 sec0.30.40.9-0.51.0-0.2
Delay discounting time to switch 0 sec0.10.10.1-0.30.30.3
Delay discounting water rate 0 sec0.00.00.0-0.2-0.20.1
Delay discounting water rate 12 sec0.40.50.80.90.6-0.7
Delay discounting water rate 18 sec0.00.10.1-0.30.20.2
Delay discounting water rate 24 sec0.40.60.7-0.9-0.60.8
Delay discounting water rate 6 sec0.00.00.00.20.2-0.1
Locomotor activity0.10.10.20.10.5-0.3
Locomotor testing distance0.81.32.40.61.5-1.0
Locomotor testing rearing0.40.60.70.70.7-0.8
Light reinforcement 10.20.30.7-0.40.8-0.2
Light reinforcement 20.20.20.30.50.4-0.5
Reaction time number correct0.70.91.50.91.2-0.7
Reaction time mean minus median0.00.00.00.1-0.1-0.1
Reaction time mean minus median AUC0.10.10.2-0.4-0.40.2
Reaction time num false alarms0.60.91.60.71.3-0.8
Reaction time num false alarms AUC0.40.61.40.41.2-0.6
Reaction time trials correct on left0.70.91.50.91.2-0.7
Reaction time trials on left0.81.11.61.01.2-0.8
Reaction time mean0.10.20.4-0.2-0.60.3
Reaction time mean AUC0.20.30.6-0.1-0.80.3
Median of all reaction times0.20.20.5-0.2-0.70.3
Reaction time omissions1.31.72.41.60.7-1.5
Reaction time false alarm rate0.10.10.2-0.50.20.2
Reaction time premature initiation rate1.11.53.10.61.8-1.1
Reaction time premature initiations1.92.75.01.22.2-1.4
Std. dev. reaction times0.00.10.2-0.0-0.40.1
Reaction time trials completed0.81.11.61.01.2-0.8
Reaction time trials AUC0.50.81.20.91.1-0.6
Social response proportion2.12.33.31.21.8-1.4
Social responses0.71.01.11.00.9-1.0
Social time1.62.13.11.71.0-1.5
Conditioned locomotion0.30.40.70.80.5-0.6
Cocaine response after cond. corrected0.00.00.00.1-0.1-0.0
Cocaine response after cond. not corrected0.10.10.10.30.3-0.3
Cocaine response before conditioning1.01.22.40.61.6-0.9
Saline control response0.10.20.5-0.10.7-0.1
Condit. Reinf. active minus inactive responses1.11.41.7-1.2-0.91.3
Condit. Reinf. active-inactive response ratio0.50.50.7-0.7-0.50.8
Condit. Reinf. active responses1.31.72.6-1.6-0.81.4
Condit. Reinf. inactive responses0.10.20.4-0.60.00.4
Condit. Reinf. lever presses0.40.51.10.31.0-0.6
Condit. Reinf. lever reinforcers received0.40.61.1-1.0-0.20.8
Pavlov. Cond. lever latency1.21.73.0-0.8-1.71.2
Pavlov. Cond. magazine entry latency2.83.34.02.01.4-2.0
Pavlov. Cond. change in total contacts0.71.01.6-1.3-0.41.1
Pavlov. Cond. index score1.82.42.61.41.6-1.6
Pavlov. Cond. latency score1.62.12.41.31.6-1.5
Pavlov. Cond. lever contacts2.23.04.51.42.1-1.7
Pavlov. Cond. magazine entry number0.70.91.1-1.0-0.71.0
Pavlov. Cond. intertrial magazine entries0.70.90.90.91.0-0.9
Pavlov. Cond. lever-magazine prob. diff.1.21.51.61.21.3-1.3
Pavlov. Cond. response bias1.92.63.21.41.8-1.6
Conditioned reinforcement - actives0.60.61.3-1.10.40.6
Conditioned reinforcement - inactives0.20.20.60.00.8-0.2
Conditioned locomotion0.30.40.7-0.70.80.0
Intermittent access intake day 1-15 change0.60.61.40.21.2-0.5
Intermittent access intake escalation0.40.41.1-0.21.1-0.4
Intermittent access intake escalation 20.20.20.5-0.00.7-0.3
Intermitt. access day 1 inactive lever presses0.20.20.4-0.70.00.3
Intermitt. access day 15 inactive lever presses0.80.81.01.00.9-0.8
Intermitt. access escalation Index2.42.13.6-1.9-1.11.3
Intermittent access day 1 total infusions0.30.30.6-0.80.50.2
Intermittent access day 15 total infusions0.50.51.3-0.41.1-0.3
Intermittent access terminal intake (last 3 days)0.90.92.0-1.40.80.4
Intermittent access total infusions0.91.02.4-1.60.50.5
Intermittent access day 1 locomotion0.70.81.9-0.51.4-0.3
Intermittent access day 15 total locomotion0.90.92.00.31.4-0.8
Intermittent access total locomotion0.70.81.7-0.71.3-0.2
Intermittent access standard deviation1.01.01.31.00.9-1.1
Cocaine induced anxiety0.10.10.2-0.50.00.2
Post-drug Anxiety1.21.41.9-1.4-0.91.2
Baseline Anxiety0.10.10.30.0-0.60.2
Lifetime Intake0.70.81.8-1.30.80.2
Incentive Sensitization - Responses0.30.30.6-0.6-0.10.8
Incentive Sensitization - Breakpoint0.60.60.9-0.8-0.31.0
Progressive ratio test 1 active lever presses1.71.74.5-0.62.1-0.6
Progressive ratio test 1 breakpoint1.31.43.5-0.61.9-0.5
Progressive ratio test 1 inactive lever presses0.50.51.0-0.71.00.0
Progressive ratio test 2 active lever presses0.90.91.4-1.21.10.3
Progressive ratio test 2 breakpoint0.70.81.4-1.21.00.3
Progressive ratio test 2 inactive lever presses0.40.51.2-0.41.1-0.2
Total sessions with >9 infusions1.41.63.8-2.00.00.9
Short access day 1 total inactive lever presses0.50.51.4-0.41.2-0.1
Short access day 10 total inactive lever presses0.00.00.00.20.1-0.0
Short access day 1 total infusions0.20.20.6-0.30.8-0.0
Short access day 10 total infusions0.40.50.9-1.00.7-0.0
Short access total infusions0.30.40.7-0.80.6-0.1
Short access day 1 locomotion0.10.10.10.20.3-0.3
Short access day 10 total locomotion0.00.00.0-0.10.0-0.2
Short access total locomotion0.10.10.1-0.40.2-0.1
Compulsive drug intake2.52.53.8-1.9-1.01.6
One hour access (0.3 mA shock)3.03.56.1-2.5-1.11.8
One hour access (shock baseline)1.41.62.2-1.5-1.21.1
Number of responses in last shaping day1.71.72.71.61.1-1.1
Context. condit. distance diff. score0.10.10.2-0.50.30.4
Locomotion velocity, session 15.25.65.72.32.4-2.4
Locomotion distance, session 11.31.71.91.41.3-1.2
Locomotion velocity, session 23.33.95.52.41.2-2.1
Locomotion distance, session 21.52.12.11.41.5-1.5
Locomotion velocity, session 35.46.36.72.42.6-2.5
Locomotion distance, session 34.65.05.32.22.3-2.3
Stereotopy head waving bouts, day 32.12.52.6-1.6-1.61.6
Stereotopy head waving duration, day 30.10.20.2-0.4-0.50.4
Locomotion velocity, session 71.01.12.20.31.5-0.9
Locomotion distance, session 73.13.94.81.81.9-2.2
Stereotopy head waving bouts, day 73.03.44.0-1.9-1.62.0
Stereotopy head waving duration, day 73.03.74.4-2.1-1.62.1
Locomotion velocity, session 80.10.20.40.20.6-0.2
Locomotion distance, session 81.72.53.21.41.8-1.5
Degree of sensitization distance0.50.50.6-0.7-0.80.6
Degree of sensitization stereotypy2.72.93.7-1.9-1.21.9
Condit. Reinf. active minus inactive responses0.40.50.70.70.8-0.6
Condit. Reinf. active-inactive response ratio0.50.60.80.70.9-0.7
Condit. Reinf. active responses1.11.31.51.21.1-1.0
Condit. Reinf. inactive responses1.11.31.71.31.0-1.1
Incentive salience index mean0.10.10.20.20.5-0.2
Condit. Reinf. lever presses0.40.50.7-0.7-0.60.8
Time in familiar zone, hab. session 10.70.71.21.10.3-0.9
Time in novel zone, hab. session 12.42.43.3-1.8-1.11.6
Total zone transitions, hab. session 10.20.30.5-0.7-0.20.5
Total locomotion distance, hab. session 10.60.81.00.81.0-0.9
Locomotion velocity, hab. session 10.60.91.01.00.9-1.0
Time in familiar zone, hab. session 20.00.00.10.2-0.2-0.1
Time in novel zone, hab. session 20.40.40.6-0.7-0.50.7
Total zone transitions, hab. session 20.40.50.60.50.8-0.7
Total locomotion distance, hab. session 20.81.01.51.20.6-1.1
Locomotion velocity, hab. session 21.11.52.31.50.7-1.3
Novel to familiar place preference ratio0.70.70.9-0.6-1.00.9
Novelty place preference0.50.50.7-0.5-0.80.8
Time in novel zone, NPP test0.70.81.0-0.7-1.00.9
Total zone transitions, NPP test1.21.82.41.11.6-1.3
Total locomotion distance, NPP test2.94.14.62.11.8-2.1
Locomotion velocity, NPP test3.44.95.72.41.9-2.3
Pavlov. Cond. lever latency1.82.33.51.91.0-1.6
Pavlov. Cond. magazine entry latency3.44.45.5-2.3-1.62.2
Pavlov. Cond. change in total contacts4.14.35.4-2.3-1.72.2
Pavlov. Cond. index score4.55.87.1-2.7-2.02.5
Pavlov. Cond. latency score4.45.67.2-2.7-1.92.5
Pavlov. Cond. lever contacts1.82.23.0-1.7-1.01.5
Pavlov. Cond. magazine entry number1.62.02.61.61.1-1.6
Pavlov. Cond. intertrial magazine entries2.12.52.81.51.6-1.7
Pavlov. Cond. lever-magazine prob. diff.4.45.66.9-2.6-1.92.5
Pavlov. Cond. response bias1.82.22.7-1.6-1.21.6
Bone: apparent density0.20.40.9-0.0-1.00.5
Bone surface0.71.21.9-0.7-1.41.1
Bone volume0.81.32.0-0.8-1.41.2
Bone: connectivity density0.10.10.20.40.0-0.3
Bone: cortical apparent density0.60.80.8-0.9-0.90.9
Bone: cortical area0.60.91.1-0.7-1.01.0
Bone: cortical porosity1.41.51.71.31.2-1.2
Bone: cortical porosity1.51.61.71.31.2-1.2
Bone: cortical thickness0.10.10.2-0.2-0.50.4
Bone: cortical thickness1.41.62.51.60.8-1.3
Bone: cortical tissue density0.50.60.7-0.8-0.80.8
Bone: elastic displacement4.95.66.22.22.5-2.4
Bone: elastic work3.03.95.22.31.5-2.1
Bone: endosteal estimation0.71.52.1-0.8-1.51.3
Bone: endosteal perimeter1.12.33.1-1.0-1.81.6
Bone: final force0.40.61.4-0.2-1.20.7
Bone: final moment0.40.71.5-0.2-1.20.7
Bone: marrow area0.71.52.0-0.8-1.41.3
Bone: maximum diameter0.50.91.4-0.9-0.61.2
Bone: maximum force0.91.52.5-0.8-1.61.2
Bone: maximum moment0.91.62.7-0.7-1.71.3
Bone: minimum diameter1.01.82.4-0.9-1.51.4
Bone: periosteal estimation0.91.82.2-1.0-1.51.5
Bone: periosteal perimeter2.03.44.3-1.4-2.12.0
Bone: post-yield work0.81.01.3-0.9-1.11.0
Bone: stiffness2.84.45.8-1.7-2.42.1
Bone: tissue strength1.91.92.2-1.3-1.51.3
Bone: trabecular number0.20.20.50.70.0-0.5
Bone: trabecular spacing1.01.32.7-1.60.21.1
Bone: trabecular thickness0.10.10.20.4-0.3-0.0
Bone: trabecular tissue density1.41.92.5-1.6-0.91.6
Breakpoint value in progressive ratio session1.21.32.1-1.4-1.10.8
Distance traveled before self-admin0.10.10.2-0.40.50.1
Distance traveled after self-admin1.41.54.20.22.1-0.5
Delta time in closed arm before/after self-admin0.50.50.9-0.6-0.90.4
Delta time in open arm before/after self-admin5.04.86.02.31.8-2.4
Diff in mean of infusions in LGA sessions1.11.33.2-0.3-1.80.8
Extinction: sum of active levers before priming2.02.03.6-1.1-1.91.2
Active lever presses in extinction session 60.20.20.4-0.5-0.70.3
Delta distance traveled before/after self-admin2.72.94.51.52.1-1.5
Delta ambulatory time before/after self-admin2.52.74.61.32.2-1.4
Time in closed arm before self-admin0.10.10.4-0.0-0.10.6
Time in closed arm after self-admin2.62.73.5-1.9-1.41.7
Time in open arm before self-admin2.72.83.8-1.9-1.11.9
Time in open arm after self-admin0.90.91.81.40.5-0.9
Sum of active levers in priming session hrs 5-60.80.82.1-1.5-0.30.5
Time to tail flick, vehicle, before self-admin0.40.41.0-0.4-1.00.4
Time to tail flick, vehicle, after self-admin0.10.10.20.3-0.50.2
Time to tail flick, test, before self-admin0.00.00.00.2-0.10.1
Time to tail flick, test, after self-admin0.70.81.9-0.4-1.40.5
Delta time to tail flick, vehicle, before/after SA0.10.10.20.40.5-0.2
Delta time to tail flick, test, before/after SA0.50.51.0-0.4-1.00.5
Ambulatory time before self-admin0.20.20.4-0.70.20.0
Ambulatory time after self-admin1.21.33.50.31.9-0.7
Total heroin consumption0.10.20.2-0.5-0.40.3
Area under the delay curve0.10.10.2-0.3-0.40.4
Delay disc. indifference point, 0s delay0.10.10.20.4-0.40.0
Delay disc. indifference point, 16s delay0.10.10.2-0.3-0.40.4
Delay disc. indifference point, 2s delay5.96.67.4-2.6-2.32.7
Delay disc. indifference point, 24s delay0.10.10.1-0.4-0.30.4
Delay disc. indifference point, 4s delay0.20.20.3-0.4-0.40.5
Delay disc. indifference point, 8s delay0.10.10.20.20.4-0.2
Delay discount exponential model param0.20.20.30.40.5-0.6
Delay discount hyperbolic model param0.50.60.70.70.7-0.9
Fecal boli incidents, locomotor time 13.84.14.91.72.2-2.1
Change in fecal boli incidents, locomotor task1.71.62.8-0.8-1.71.1
Time >=10cm from walls, locomotor time 10.50.60.90.60.9-0.6
Bouts of movement, locomotor time 10.50.61.10.51.1-0.6
Total resting periods, locomotor time 11.21.41.61.11.3-1.1
Rest time, locomotor task time 10.60.71.10.61.1-0.8
Distance moved, locomotor task time 11.31.41.5-1.2-1.21.1
Vertical activity count, locomotor time 12.32.42.9-1.7-1.31.6
Time >=10cm from walls, locomotor time 20.50.51.20.31.1-0.5
Bouts of movement, locomotor time 21.92.12.7-1.7-1.11.5
Total resting periods, locomotor time 22.52.73.2-1.8-1.41.7
Rest time, locomotor task time 20.00.00.00.20.2-0.2
Distance moved, locomotor task time 20.00.00.10.3-0.1-0.0
Vertical activity count, locomotor time 20.10.10.2-0.4-0.30.4
Weight adjusted by age0.50.61.40.6-1.20.1
Seeking ratio, delayed vs. immediate footshock0.10.10.30.1-0.50.0
Locomotion in novel chamber2.42.94.2-1.4-2.01.6
Locomotion in novel chamber post-restriction1.11.32.4-1.5-1.00.7
Progressive ratio0.00.00.0-0.20.2-0.0
Food seeking constrained by brief footshock1.31.62.9-1.31.70.2
Seeking ratio, punishment vs. effort0.20.20.4-0.40.60.1
Run reversals in cocaine runway, females0.10.10.20.40.00.0
Run reversals in cocaine runway, males0.80.81.7-0.1-1.30.8
Latency to leave start box in cocaine runway0.30.30.5-0.7-0.30.6
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.00.4
Latency to leave start box in cocaine runway, M0.90.91.2-1.1-0.80.9
Cd content in liver0.50.61.50.11.2-0.4
Co content in liver0.10.20.4-0.6-0.10.3
Cu content in liver2.12.55.1-2.3-0.01.5
Fe content in liver0.10.10.2-0.10.4-0.4
K content in liver0.10.10.10.00.4-0.3
Mg content in liver0.30.30.9-0.10.9-0.3
Mn content in liver0.00.00.10.2-0.3-0.0
Na content in liver0.10.10.4-0.60.10.2
Rb content in liver0.70.91.5-1.11.20.3
Se content in liver0.70.81.40.61.2-0.8
Sr content in liver1.11.01.51.20.5-1.2
Zn content in liver2.22.45.10.72.3-1.2