Hub : Traits

Locomotor testing distance

Distance traveled in a novel 24 X 45 cm chamber in the 18-minute session for males and females [cm],locomotor_testing_distance

Tags: Behavior · Locomotion

Project: p50_david_dietz

6 significantly associated models · 4 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	60576851	62029190	2	1	2.4e-07	1.3e-07	2.2e-81	-1210	Pnpla8
2	10	25764403	27626792	2	1	8.8e-08	5.2e-08	1.0e+00	100	Gabrg2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Length with tail	3.5	4	0	0	-0.53	0.277	Gabrg2 Gabrb2 Pnpla8 NA
Length without tail	4.9	3	0	0	-0.86	0.065	Gabrg2 Pnpla8 NA
Tibialis anterior weight	2.7	2	0	0	0.00	1.000	Pnpla8 NA
Times rat made contact with spout	6.7	2	0	0	0.00	1.000	Pnpla8 NA
Delay discounting time to switch 0 sec	7.7	2	0	0	0.00	1.000	Pnpla8 NA
Locomotor activity	11.5	4	2	100	-0.58	0.224	Gabrg2 Gabrb2 Pnpla8 NA
Locomotor testing rearing	12.6	4	0	0	0.83	0.041	Gabrg2 Gabrb2 Pnpla8 NA
Reaction time number correct	11.5	2	0	0	0.66	0.336	Gabrg2 Gabrb2
Reaction time mean minus median	6.5	2	0	0	-0.50	0.504	Gabrg2 Gabrb2
Reaction time trials correct on left	11.5	2	0	0	0.66	0.336	Gabrg2 Gabrb2
Reaction time trials on left	11.7	2	0	0	0.66	0.342	Gabrg2 Gabrb2
Reaction time mean	8.7	2	0	0	-0.09	0.914	Gabrg2 Gabrb2
Reaction time mean AUC	8.4	2	0	0	0.01	0.995	Gabrg2 Gabrb2
Median of all reaction times	6.8	2	0	0	0.23	0.768	Gabrg2 Gabrb2
Std. dev. reaction times	5.5	1	0	0	0.00	1.000	Gabrg2
Reaction time trials completed	11.7	2	0	0	0.66	0.342	Gabrg2 Gabrb2
Reaction time trials AUC	12.3	2	0	0	0.59	0.408	Gabrg2 Gabrb2
Conditioned locomotion	9.1	2	0	0	0.00	1.000	Pnpla8 NA
Condit. Reinf. active responses	5.1	1	0	0	0.00	1.000	Gabrg2
Condit. Reinf. lever reinforcers received	5.2	2	0	0	-0.36	0.638	Gabrg2 Gabrb2
Bone: cortical area	4.8	1	0	0	0.00	1.000	Gabrb2
Bone: cortical thickness	5.0	1	0	0	0.00	1.000	Gabrb2
Run reversals in cocaine runway, females	7.6	2	0	0	0.00	1.000	Pnpla8 NA
Cd content in liver	10.8	2	0	0	-0.35	0.649	Gabrg2 Gabrb2
Co content in liver	7.2	2	0	0	0.00	1.000	Pnpla8 NA

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	0	0.000	1.7
Adipose	alternative TSS	0	0.000	1.6
Adipose	gene expression	1	0.012	1.6
Adipose	isoform ratio	0	0.000	1.7
Adipose	intron excision ratio	0	0.000	1.7
Adipose	mRNA stability	0	0.000	1.7
BLA	alternative polyA	0	0.000	1.6
BLA	alternative TSS	0	0.000	1.7
BLA	gene expression	1	0.016	1.7
BLA	isoform ratio	0	0.000	1.7
BLA	intron excision ratio	0	0.000	1.7
BLA	mRNA stability	0	0.000	1.8
Brain	alternative polyA	0	0.000	1.6
Brain	alternative TSS	0	0.000	1.6
Brain	gene expression	0	0.000	1.7
Brain	isoform ratio	0	0.000	1.7
Brain	intron excision ratio	0	0.000	1.7
Brain	mRNA stability	1	0.023	1.7
Eye	alternative polyA	0	0.000	1.9
Eye	alternative TSS	0	0.000	1.5
Eye	gene expression	0	0.000	1.7
Eye	isoform ratio	0	0.000	1.6
Eye	intron excision ratio	0	0.000	1.8
Eye	mRNA stability	0	0.000	1.6
IL	alternative polyA	0	0.000	1.6
IL	alternative TSS	0	0.000	2.0
IL	gene expression	0	0.000	1.7
IL	isoform ratio	0	0.000	1.5
IL	intron excision ratio	0	0.000	1.8
IL	mRNA stability	1	0.090	1.8
LHb	alternative polyA	0	0.000	1.4
LHb	alternative TSS	0	0.000	1.7
LHb	gene expression	0	0.000	1.7
LHb	isoform ratio	0	0.000	1.8
LHb	intron excision ratio	0	0.000	1.7
LHb	mRNA stability	0	0.000	1.7
Liver	alternative polyA	0	0.000	1.6
Liver	alternative TSS	0	0.000	1.5
Liver	gene expression	0	0.000	1.6
Liver	isoform ratio	0	0.000	1.6
Liver	intron excision ratio	0	0.000	1.5
Liver	mRNA stability	0	0.000	1.6
NAcc	alternative polyA	0	0.000	1.6
NAcc	alternative TSS	0	0.000	1.7
NAcc	gene expression	0	0.000	1.7
NAcc	isoform ratio	0	0.000	1.7
NAcc	intron excision ratio	0	0.000	1.7
NAcc	mRNA stability	1	0.044	1.7
OFC	alternative polyA	0	0.000	1.5
OFC	alternative TSS	0	0.000	1.9
OFC	gene expression	1	0.027	1.7
OFC	isoform ratio	0	0.000	1.6
OFC	intron excision ratio	0	0.000	1.9
OFC	mRNA stability	0	0.000	1.8
PL	alternative polyA	0	0.000	1.5
PL	alternative TSS	0	0.000	1.8
PL	gene expression	0	0.000	1.7
PL	isoform ratio	0	0.000	1.7
PL	intron excision ratio	0	0.000	1.6
PL	mRNA stability	0	0.000	1.7

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.