Hub : Traits

Locomotor testing distance

Distance traveled in a novel 24 X 45 cm chamber in the 18-minute session for males and females [cm],locomotor_testing_distance

Tags: Behavior · Locomotion

Project: p50_david_dietz

4 loci · 4 genes with independent associations · 24 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr6	60576851	62029190	9	1	1.83e-08	1.29e-07	2.64e-99	Pnpla8
2	chr8	108585012	109845634	1	1	3.40e-25	2.31e-03	6.98e-13	Klhdc8b
3	chr9	75969545	77365260	1	1	7.32e-19	1.28e-02	1.00e+00	Zfand2b
4	chr10	24487967	27163082	13	1	6.12e-08	5.22e-08	1.00e+00	LOC102548672

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	13.63	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
BMI without tail	40.36	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Body weight	11.67	2	1	25	0	1.00e+00	Klhdc8b Pnpla8
Epididymis fat weight	111.28	1	1	25	0	1.00e+00	Zfand2b
Heart weight	44.47	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Left kidney weight	27.6	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Right kidney weight	32.19	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Tail length	66.87	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Length with tail	3.92	7	2	50	0.88	6.50e-11	Gabrg2 Klhdc8b LOC102548672 LOC103692619 LOC120103526 Pnpla8 Zfand2b
Length without tail	12.47	4	1	25	0.95	9.48e-06	LOC103692619 LOC120103526 Pnpla8 Zfand2b
Liver weight, left	13.45	1	0	0	0	1.00e+00	Klhdc8b
Liver weight, right	17.57	1	1	25	0	1.00e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1.00e+00	Zfand2b
Retroperitoneal fat weight	6.88	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Intraocular pressure	51.69	1	1	25	0	1.00e+00	Zfand2b
Soleus weight	8.84	1	0	0	0	1.00e+00	Klhdc8b
Tibialis anterior weight	4.8	1	0	0	0	1.00e+00	Pnpla8
Tibia length	10.96	1	1	25	0	1.00e+00	Klhdc8b
Number of licking bursts	28.51	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Food consumed during 24 hour testing period	12.4	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1.00e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	14.92	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	25	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	9.99	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Patch foraging indifference point AUC	24.2	1	1	25	0	1.00e+00	Zfand2b
Indifference point function ln k	45.4	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Indifference point function log k	45.4	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Patch foraging total patch changes 0 sec	16.18	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	25	0	1.00e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	25	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	25	0	1.00e+00	Zfand2b
Patch foraging time to switch 0 sec	10.56	4	1	25	-0.96	2.02e-06	Klhdc8b LOC103692619 LOC120103526 Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	25	0	1.00e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	25	0	1.00e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	25	0	1.00e+00	Zfand2b
Locomotor activity	12.46	8	4	100	0.98	1.71e-27	Ccng1 Gabrg2 Klhdc8b LOC102548672 LOC103692619 LOC120103526 Pnpla8 Zfand2b
Locomotor testing rearing	15.5	7	2	50	0.99	3.07e-30	Ccng1 Gabrg2 LOC102548672 LOC103692619 LOC120103526 Pnpla8 Zfand2b
Light reinforcement 1	19.25	1	1	25	0	1.00e+00	Zfand2b
Reaction time number correct	15.27	4	2	50	0.82	1.58e-07	Gabrg2 Klhdc8b LOC102548672 Zfand2b
Reaction time mean minus median	66.97	2	1	25	0	1.00e+00	Ccng1 Zfand2b
Reaction time mean minus median AUC	84.84	2	1	25	0	1.00e+00	Ccng1 Zfand2b
Reaction time num false alarms AUC	27.43	1	1	25	0	1.00e+00	Zfand2b
Reaction time trials correct on left	15.27	4	2	50	0.82	1.58e-07	Gabrg2 Klhdc8b LOC102548672 Zfand2b
Reaction time trials on left	15.2	4	2	50	0.82	1.46e-07	Gabrg2 Klhdc8b LOC102548672 Zfand2b
Reaction time mean	9.71	4	1	25	-1	8.56e-32	Ccng1 Gabrg2 LOC102548672 Zfand2b
Reaction time mean AUC	9.7	5	1	25	-0.98	2.68e-21	Ccng1 Gabrg2 Klhdc8b LOC102548672 Zfand2b
Median of all reaction times	10.97	4	0	0	-1	3.80e-05	Ccng1 Klhdc8b LOC102548672 Zfand2b
Reaction time omissions	35.15	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Reaction time false alarm rate	20.24	1	1	25	0	1.00e+00	Klhdc8b
Reaction time premature initiations	41.6	1	1	25	0	1.00e+00	Zfand2b
Std. dev. reaction times	30.84	2	1	25	0	1.00e+00	Ccng1 Zfand2b
Reaction time trials completed	15.2	4	2	50	0.82	1.46e-07	Gabrg2 Klhdc8b LOC102548672 Zfand2b
Reaction time trials AUC	15.87	4	2	50	0.82	1.42e-07	Gabrg2 Klhdc8b LOC102548672 Zfand2b
Conditioned locomotion	11.47	3	1	25	-1	1.56e-10	Klhdc8b LOC103692619 LOC120103526
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. not corrected	13.66	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Cocaine response before conditioning	38.66	1	1	25	0	1.00e+00	Klhdc8b
Saline control response	8.43	1	0	0	0	1.00e+00	Zfand2b
Pavlov. Cond. magazine entry number	30	1	1	25	0	1.00e+00	Klhdc8b
Conditioned reinforcement - actives	152.54	1	1	25	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	76.2	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	25	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	25	0	1.00e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	91.66	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Intermitt. access day 15 inactive lever presses	162.52	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	25	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	24.8	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access terminal intake (last 3 days)	24.92	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access total infusions	15.45	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access day 1 locomotion	18.98	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	25	0	1.00e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1.00e+00	Zfand2b
Intermittent access standard deviation	229.66	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Cocaine induced anxiety	69.5	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Baseline Anxiety	393.92	1	1	25	0	1.00e+00	Zfand2b
Lifetime Intake	9.49	1	0	0	0	1.00e+00	Klhdc8b
Incentive Sensitization - Responses	309.83	1	1	25	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	25	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	25	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 2 active lever presses	109.22	1	1	25	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	25	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	37.15	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Total sessions with >9 infusions	16	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 total inactive lever presses	17.49	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Short access day 10 total inactive lever presses	72.35	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Short access day 10 total infusions	13.17	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 locomotion	70.49	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Short access day 10 total locomotion	432.47	1	1	25	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	25	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	25	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	18.01	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Number of responses in last shaping day	67.75	1	1	25	0	1.00e+00	Zfand2b
Locomotion distance, session 1	23.98	1	1	25	0	1.00e+00	Klhdc8b
Locomotion velocity, session 2	10	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 2	33.15	1	1	25	0	1.00e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 3	14.51	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, session 8	9.36	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 8	52.78	1	1	25	0	1.00e+00	Klhdc8b
Degree of sensitization distance	24.75	1	0	0	0	1.00e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	35.59	1	1	25	0	1.00e+00	Klhdc8b
Condit. Reinf. active-inactive response ratio	25.6	1	1	25	0	1.00e+00	Klhdc8b
Condit. Reinf. active responses	18.23	1	0	0	0	1.00e+00	Klhdc8b
Incentive salience index mean	26.23	1	1	25	0	1.00e+00	Klhdc8b
Condit. Reinf. lever presses	10.81	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	25	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 1	13.1	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 1	37.38	1	1	25	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 1	10.76	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, hab. session 1	10.22	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 2	27.1	1	1	25	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 2	69.58	1	1	25	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 2	19.2	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, hab. session 2	21.15	1	1	25	0	1.00e+00	Klhdc8b
Novel to familiar place preference ratio	22.33	1	0	0	0	1.00e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1.00e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, NPP test	106.24	1	1	25	0	1.00e+00	Klhdc8b
Total locomotion distance, NPP test	47.64	1	1	25	0	1.00e+00	Klhdc8b
Locomotion velocity, NPP test	51.12	1	1	25	0	1.00e+00	Klhdc8b
Pavlov. Cond. change in total contacts	69.48	1	1	25	0	1.00e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. latency score	8.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	12.23	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. response bias	10.49	1	0	0	0	1.00e+00	Klhdc8b
Bone: maximum force	7.19	1	0	0	0	1.00e+00	Klhdc8b
Bone: stiffness	13.41	1	0	0	0	1.00e+00	Klhdc8b
Delta time in closed arm before/after self-admin	12.84	1	0	0	0	1.00e+00	Klhdc8b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	25	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	56.6	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	44.54	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Total heroin consumption	18.89	1	0	0	0	1.00e+00	Klhdc8b
Area under the delay curve	31.15	1	1	25	0	1.00e+00	Zfand2b
Delay disc. indifference point, 0s delay	28.7	1	1	25	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 16s delay	41.08	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 4s delay	41.82	1	1	25	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 8s delay	74.24	1	1	25	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	96.73	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	25	0	1.00e+00	Zfand2b
Rest time, locomotor task time 1	17.01	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Distance moved, locomotor task time 1	31.01	1	1	25	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 1	73.36	2	2	50	0	1.00e+00	Klhdc8b Zfand2b
Bouts of movement, locomotor time 2	21.88	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Total resting periods, locomotor time 2	28.25	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Rest time, locomotor task time 2	24.06	3	2	50	-0.22	7.77e-01	Ccng1 Klhdc8b Zfand2b
Distance moved, locomotor task time 2	45.67	3	2	50	0	1.00e+00	Ccng1 Klhdc8b Zfand2b
Vertical activity count, locomotor time 2	34.04	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Weight adjusted by age	20.12	2	1	25	0	1.00e+00	Klhdc8b Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	13.85	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	25	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	25	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	25	0	1.00e+00	Zfand2b
Cd content in liver	12.26	4	1	25	0.82	1.01e-07	Ccng1 Gabrg2 Klhdc8b LOC102548672
Fe content in liver	40.39	1	1	25	0	1.00e+00	Klhdc8b
K content in liver	12.22	1	0	0	0	1.00e+00	Klhdc8b
Mg content in liver	15.79	1	0	0	0	1.00e+00	Klhdc8b
Na content in liver	16.36	1	0	0	0	1.00e+00	Klhdc8b
Rb content in liver	51.88	1	1	25	0	1.00e+00	Klhdc8b
Sr content in liver	22.41	1	0	0	0	1.00e+00	Klhdc8b
Zn content in liver	9.95	1	0	0	0	1.00e+00	Klhdc8b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	4	0.1	1.76
Adipose	alternative TSS	0	0	1.52
Adipose	gene expression	1	0	1.62
Adipose	isoform ratio	1	0	1.63
Adipose	intron excision ratio	0	0	1.62
Adipose	mRNA stability	0	0	1.64
BLA	alternative polyA	0	0	1.63
BLA	alternative TSS	0	0	1.63
BLA	gene expression	1	0	1.73
BLA	isoform ratio	2	0.1	1.66
BLA	intron excision ratio	2	0.1	1.8
BLA	mRNA stability	1	0	1.73
Brain	alternative polyA	0	0	1.68
Brain	alternative TSS	0	0	1.67
Brain	gene expression	1	0	1.66
Brain	isoform ratio	1	0	1.65
Brain	intron excision ratio	1	0	1.72
Brain	mRNA stability	2	0	1.67
Eye	alternative polyA	0	0	1.59
Eye	alternative TSS	0	0	1.84
Eye	gene expression	0	0	1.67
Eye	isoform ratio	0	0	1.58
Eye	intron excision ratio	0	0	1.71
Eye	mRNA stability	0	0	1.64
IL	alternative polyA	0	0	1.64
IL	alternative TSS	0	0	1.55
IL	gene expression	1	0	1.71
IL	isoform ratio	0	0	1.68
IL	intron excision ratio	0	0	1.84
IL	mRNA stability	0	0	1.79
LHb	alternative polyA	0	0	1.63
LHb	alternative TSS	0	0	1.65
LHb	gene expression	0	0	1.67
LHb	isoform ratio	0	0	1.72
LHb	intron excision ratio	0	0	1.73
LHb	mRNA stability	0	0	1.73
Liver	alternative polyA	0	0	1.61
Liver	alternative TSS	0	0	1.56
Liver	gene expression	1	0	1.63
Liver	isoform ratio	0	0	1.56
Liver	intron excision ratio	0	0	1.55
Liver	mRNA stability	0	0	1.59
NAcc	alternative polyA	0	0	1.63
NAcc	alternative TSS	0	0	1.79
NAcc	gene expression	2	0	1.7
NAcc	isoform ratio	0	0	1.7
NAcc	intron excision ratio	3	0.1	1.63
NAcc	mRNA stability	2	0.1	1.67
OFC	alternative polyA	0	0	1.61
OFC	alternative TSS	0	0	1.63
OFC	gene expression	0	0	1.71
OFC	isoform ratio	0	0	1.66
OFC	intron excision ratio	0	0	1.76
OFC	mRNA stability	0	0	1.76
PL	alternative polyA	0	0	1.65
PL	alternative TSS	0	0	1.66
PL	gene expression	3	0	1.71
PL	isoform ratio	0	0	1.67
PL	intron excision ratio	1	0	1.69
PL	mRNA stability	1	0	1.71
pVTA	alternative polyA	2	0.1	1.62
pVTA	alternative TSS	0	0	1.78
pVTA	gene expression	1	0	1.65
pVTA	isoform ratio	0	0	1.69
pVTA	intron excision ratio	2	0.1	1.7
pVTA	mRNA stability	2	0.1	1.82
RMTg	alternative polyA	0	0	1.4
RMTg	alternative TSS	0	0	1.79
RMTg	gene expression	1	0.1	1.74
RMTg	isoform ratio	0	0	1.59
RMTg	intron excision ratio	0	0	1.73
RMTg	mRNA stability	0	0	1.74