Fibp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	alternative TSS	ENSRNOT00000027927	0.27	0.14	1.2e-03	0.09	0.07	0.13	0.07	4.2e-03	1.1e-02	5.4e-04	1.2e-02
2	IL	alternative TSS	ENSRNOT00000097955	0.28	0.14	1.1e-03	0.09	0.07	0.13	0.07	4.2e-03	1.0e-02	4.4e-04	1.1e-02
3	NAcc	gene expression	ENSRNOG00000020567	0.1	0.06	5.3e-06	0.07	0.07	0.06	0.07	6.9e-06	5.6e-06	2.4e-05	1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	6.5	21.1	24.9	-5.0	5.0	-3.7
BMI without tail	2.8	5.8	7.0	-2.7	2.6	-1.8
Body weight	2.6	11.1	20.0	-2.6	2.6	-4.5
Epididymis fat weight	0.8	2.0	5.9	0.0	-0.0	2.4
Glucose	1.1	1.6	2.3	-1.1	1.1	1.5
Heart weight	1.3	1.9	5.8	0.0	-0.0	2.4
Left kidney weight	0.1	0.4	1.1	0.3	-0.2	1.1
Right kidney weight	0.2	0.4	0.6	0.8	-0.8	0.2
Tail length	0.9	2.6	3.5	1.9	-1.9	-0.9
Length with tail	0.8	2.8	7.0	0.9	-0.8	-2.6
Length without tail	0.9	2.0	6.0	-0.2	0.2	-2.4
Liver weight, left	0.0	0.0	0.1	-0.0	0.0	0.2
Liver weight, right	0.1	0.2	0.3	0.3	-0.3	0.5
Parametrial fat weight	1.2	2.4	3.0	-1.4	1.5	1.7
Retroperitoneal fat weight	1.7	5.8	17.3	0.1	-0.1	4.2
Intraocular pressure	1.3	1.8	2.2	1.5	-1.5	1.0
Extensor digitorum longus weight	3.9	15.7	36.9	-2.3	2.3	-6.1
Soleus weight	1.7	5.0	13.1	1.0	-0.9	3.6
Tibialis anterior weight	4.0	13.9	41.5	-0.3	0.3	-6.4
Tibia length	0.6	1.7	4.7	0.4	-0.4	-2.2
Number of licking bursts	0.2	0.3	0.6	-0.4	0.4	-0.8
Food consumed during 24 hour testing period	0.6	0.7	1.1	1.0	-1.0	-0.1
Times rat made contact with spout	0.2	0.3	0.4	-0.5	0.5	-0.6
Mean time between licks in bursts	0.1	0.1	0.1	0.3	-0.3	-0.3
Mean num. licks in bursts	0.1	0.2	0.4	0.1	-0.1	0.7
Std. dev. time between licks in bursts	0.5	0.6	0.6	0.8	-0.8	0.7
Water consumed over 24 hours	0.2	0.2	0.6	0.2	-0.2	-0.8
Indifference point 0 sec	0.0	0.1	0.1	-0.3	0.3	0.2
Indifference point AUC	1.6	1.8	5.3	-0.3	0.3	-2.3
Indifference point function ln k	4.0	5.7	15.1	1.0	-1.0	3.9
Indifference point function log k	4.0	5.7	15.1	1.0	-1.0	3.9
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	0.2	-0.2	0.3
Delay discounting total patch changes 12 sec	2.7	3.6	7.9	-1.2	1.2	-2.8
Delay discounting total patch changes 18 sec	0.7	0.9	1.2	-0.8	0.8	-1.1
Delay discounting total patch changes 24 sec	0.8	1.0	2.9	0.2	-0.2	-1.7
Delay discounting total patch changes 6 sec	0.6	0.9	1.6	-0.8	0.8	-1.3
Delay discounting time to switch 0 sec	4.2	6.5	7.2	-2.7	2.7	-2.2
Delay discounting water rate 0 sec	5.3	8.4	9.3	2.8	-2.8	3.0
Delay discounting water rate 12 sec	10.1	15.1	20.8	3.5	-3.5	4.6
Delay discounting water rate 18 sec	2.9	3.8	6.9	1.5	-1.5	2.6
Delay discounting water rate 24 sec	4.8	6.6	9.0	2.3	-2.3	3.0
Delay discounting water rate 6 sec	5.0	7.3	9.4	2.5	-2.5	3.1
Locomotor activity	2.5	4.0	4.9	1.9	-1.9	2.2
Locomotor testing distance	3.7	6.1	7.7	2.3	-2.3	2.8
Locomotor testing rearing	2.3	3.6	6.5	1.4	-1.5	2.6
Light reinforcement 1	0.3	0.5	0.5	0.7	-0.7	0.7
Light reinforcement 2	0.4	0.6	0.7	0.7	-0.7	0.8
Reaction time number correct	0.6	0.8	1.1	1.0	-1.1	-0.5
Reaction time mean minus median	2.3	3.1	6.3	-1.2	1.2	-2.5
Reaction time mean minus median AUC	0.8	1.1	3.1	-0.3	0.3	-1.8
Reaction time num false alarms	0.3	0.4	0.7	0.6	-0.6	0.8
Reaction time num false alarms AUC	0.1	0.1	0.1	0.3	-0.3	0.1
Reaction time trials correct on left	0.6	0.8	1.1	1.0	-1.1	-0.5
Reaction time trials on left	0.7	0.9	1.2	1.1	-1.1	-0.6
Reaction time mean	0.1	0.2	0.2	-0.4	0.4	-0.5
Reaction time mean AUC	0.3	0.3	0.4	-0.6	0.6	-0.5
Median of all reaction times	0.1	0.1	0.2	-0.4	0.4	0.0
Reaction time omissions	0.7	1.0	2.6	-0.5	0.5	-1.6
Reaction time false alarm rate	0.1	0.1	0.4	0.0	-0.0	0.6
Reaction time premature initiation rate	0.5	0.6	1.8	0.2	-0.3	-1.3
Reaction time premature initiations	1.1	1.6	3.5	0.8	-0.8	-1.9
Std. dev. reaction times	0.7	0.9	1.9	-0.6	0.6	-1.4
Reaction time trials completed	0.7	0.9	1.2	1.1	-1.1	-0.6
Reaction time trials AUC	0.5	0.7	1.0	1.0	-1.0	-0.4
Social response proportion	0.5	0.6	1.1	-0.6	0.6	-1.1
Social responses	0.1	0.1	0.1	0.3	-0.3	-0.3
Social time	0.2	0.3	0.3	0.6	-0.6	-0.4
Conditioned locomotion	0.5	0.6	1.9	0.0	0.0	-1.4
Cocaine response after cond. corrected	0.8	0.9	2.5	0.4	-0.4	1.6
Cocaine response after cond. not corrected	0.6	0.7	2.0	0.2	-0.2	1.4
Cocaine response before conditioning	0.4	0.5	1.2	-0.4	0.4	-1.1
Saline control response	1.4	1.9	4.9	-0.6	0.6	-2.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.4	0.4	0.3
Condit. Reinf. active responses	0.3	0.5	0.7	-0.8	0.8	-0.4
Condit. Reinf. inactive responses	0.4	0.6	0.7	-0.9	0.8	-0.5
Condit. Reinf. lever presses	1.4	1.9	4.6	-0.7	0.7	-2.1
Condit. Reinf. lever reinforcers received	0.4	0.5	0.5	-0.7	0.7	-0.7
Pavlov. Cond. lever latency	0.4	0.5	1.2	0.4	-0.4	1.1
Pavlov. Cond. magazine entry latency	2.8	3.2	5.9	-1.4	1.3	-2.4
Pavlov. Cond. change in total contacts	2.0	2.8	5.2	-1.3	1.3	-2.3
Pavlov. Cond. index score	2.0	2.6	5.3	-1.1	1.1	-2.3
Pavlov. Cond. latency score	1.8	2.2	4.4	-1.1	1.1	-2.1
Pavlov. Cond. lever contacts	0.3	0.4	0.9	0.3	-0.3	-1.0
Pavlov. Cond. magazine entry number	4.2	5.2	11.1	1.5	-1.5	3.3
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.9	0.5	-0.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	6.1	-1.2	1.2	-2.5
Pavlov. Cond. response bias	1.0	1.3	3.6	-0.5	0.5	-1.9
Conditioned reinforcement - actives	0.3	0.3	0.4	0.7	-0.6	0.4
Conditioned reinforcement - inactives	2.7	3.1	6.9	1.1	-1.1	2.6
Conditioned locomotion	5.3	6.3	11.6	1.9	-1.9	3.4
Intermittent access intake day 1-15 change	1.3	1.3	1.6	1.3	-1.3	0.8
Intermittent access intake escalation	0.7	0.6	0.7	0.9	-0.8	0.7
Intermittent access intake escalation 2	0.8	0.8	1.1	1.1	-1.1	0.4
Intermitt. access day 1 inactive lever presses	0.7	0.8	2.3	0.2	-0.2	1.5
Intermitt. access day 15 inactive lever presses	0.8	0.9	2.1	0.5	-0.5	1.5
Intermitt. access escalation Index	1.4	1.2	3.3	-0.4	0.4	1.8
Intermittent access day 1 total infusions	2.4	2.7	4.9	-1.3	1.3	2.2
Intermittent access day 15 total infusions	2.6	2.9	8.4	0.4	-0.3	2.9
Intermittent access terminal intake (last 3 days)	1.5	1.7	5.1	-0.0	0.0	2.3
Intermittent access total infusions	1.4	1.6	3.8	-0.7	0.7	2.0
Intermittent access day 1 locomotion	2.2	2.2	3.1	-1.3	1.3	1.8
Intermittent access day 15 total locomotion	1.4	1.5	4.6	0.1	-0.0	2.2
Intermittent access total locomotion	2.2	2.5	5.1	-1.1	1.1	2.3
Intermittent access standard deviation	1.0	1.1	1.4	1.0	-0.9	1.2
Cocaine induced anxiety	0.1	0.1	0.1	0.3	-0.3	-0.1
Post-drug Anxiety	0.7	0.7	1.6	0.5	-0.5	-1.3
Baseline Anxiety	0.8	0.9	2.6	0.2	-0.2	-1.6
Lifetime Intake	1.4	1.6	3.4	-0.8	0.9	1.8
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	0.2	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.1	0.1	0.6
Progressive ratio test 1 active lever presses	1.2	1.2	3.3	0.4	-0.4	1.8
Progressive ratio test 1 breakpoint	1.2	1.2	3.1	0.6	-0.6	1.8
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.5	-0.0	0.0	1.2
Progressive ratio test 2 active lever presses	1.4	1.5	4.2	0.4	-0.3	2.0
Progressive ratio test 2 breakpoint	2.4	2.6	6.2	0.9	-0.9	2.5
Progressive ratio test 2 inactive lever presses	2.8	3.2	9.5	0.2	-0.2	3.1
Total sessions with >9 infusions	0.8	0.9	1.7	-0.7	0.7	1.3
Short access day 1 total inactive lever presses	1.3	1.4	4.3	-0.1	0.1	2.1
Short access day 10 total inactive lever presses	1.8	2.0	5.0	0.7	-0.7	2.2
Short access day 1 total infusions	1.8	1.9	2.3	-1.3	1.3	1.5
Short access day 10 total infusions	2.6	2.9	4.1	-2.0	2.0	0.7
Short access total infusions	1.2	1.4	1.6	-1.3	1.3	1.0
Short access day 1 locomotion	1.3	1.4	2.1	-1.0	1.0	1.4
Short access day 10 total locomotion	1.1	1.2	1.2	-1.1	1.1	1.1
Short access total locomotion	1.2	1.2	1.3	-1.1	1.1	1.0
Compulsive drug intake	0.7	0.6	1.6	0.4	-0.4	-1.3
One hour access (0.3 mA shock)	4.4	5.2	13.0	1.1	-1.1	3.6
One hour access (shock baseline)	3.0	3.5	9.5	0.7	-0.7	3.1
Number of responses in last shaping day	1.2	1.2	2.1	0.9	-0.9	1.4
Context. condit. distance diff. score	0.7	0.9	2.7	0.0	-0.0	1.6
Locomotion velocity, session 1	0.2	0.2	0.3	0.6	-0.6	0.2
Locomotion distance, session 1	1.3	1.7	2.2	-1.5	1.5	-0.9
Locomotion velocity, session 2	2.2	2.6	4.4	-1.3	1.3	-2.1
Locomotion distance, session 2	1.1	1.5	1.7	-1.3	1.3	-1.1
Locomotion velocity, session 3	0.6	0.7	1.1	-1.0	1.0	0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.0	0.2
Stereotopy head waving bouts, day 3	0.7	0.8	0.9	-0.9	0.9	0.8
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.5	0.5	1.0
Locomotion velocity, session 7	1.9	2.1	3.1	-1.8	1.8	0.2
Locomotion distance, session 7	0.5	0.7	1.0	-1.0	1.0	0.1
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	-0.7	0.7	0.1
Stereotopy head waving duration, day 7	1.5	1.9	1.9	-1.4	1.4	-1.4
Locomotion velocity, session 8	0.3	0.3	0.5	0.5	-0.5	-0.7
Locomotion distance, session 8	0.4	0.6	0.8	-0.9	0.9	0.3
Degree of sensitization distance	0.7	0.8	1.1	-1.1	1.1	-0.1
Degree of sensitization stereotypy	0.8	0.9	1.1	-0.9	0.9	-1.1
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.7	0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.2	-0.2
Condit. Reinf. active responses	0.5	0.7	0.9	-0.9	0.9	-0.5
Condit. Reinf. inactive responses	0.6	0.7	1.0	-1.0	1.0	-0.2
Incentive salience index mean	1.0	1.3	1.5	-1.2	1.2	-0.8
Condit. Reinf. lever presses	0.6	0.8	0.9	-0.9	0.9	-1.0
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.6	0.6	0.3
Time in novel zone, hab. session 1	1.1	1.1	1.3	1.1	-1.1	0.8
Total zone transitions, hab. session 1	0.6	0.9	1.5	-0.7	0.8	-1.2
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.8	0.8	0.3
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.8	0.8	-0.1
Time in familiar zone, hab. session 2	0.5	0.5	0.7	0.8	-0.8	0.5
Time in novel zone, hab. session 2	0.7	0.7	0.9	-1.0	1.0	-0.5
Total zone transitions, hab. session 2	3.6	4.7	5.9	-2.4	2.4	-1.5
Total locomotion distance, hab. session 2	1.7	2.3	3.4	-1.9	1.9	-0.1
Locomotion velocity, hab. session 2	1.7	2.3	3.4	-1.8	1.8	-0.0
Novel to familiar place preference ratio	1.2	1.3	2.2	-0.9	0.9	-1.5
Novelty place preference	0.8	0.8	1.1	-0.8	0.8	-1.1
Time in novel zone, NPP test	0.6	0.6	0.8	-0.7	0.7	-0.9
Total zone transitions, NPP test	2.1	3.0	4.3	-1.5	1.5	-2.1
Total locomotion distance, NPP test	0.8	1.1	1.6	-1.3	1.3	-0.5
Locomotion velocity, NPP test	0.8	1.2	1.6	-1.2	1.2	-0.6
Pavlov. Cond. lever latency	0.5	0.7	0.8	0.9	-0.9	0.7
Pavlov. Cond. magazine entry latency	1.6	2.0	2.8	-1.6	1.7	-0.8
Pavlov. Cond. change in total contacts	0.9	1.0	1.2	-1.1	1.1	-0.7
Pavlov. Cond. index score	0.3	0.3	0.3	-0.6	0.6	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.7	0.7	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.5	0.6	-0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.2	-0.2	0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	0.8	-0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.8	-0.8	0.8	-0.9
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.3	0.3	-0.5
Bone: apparent density	1.9	3.2	4.3	-2.1	2.1	-1.0
Bone surface	3.6	6.4	9.8	-2.2	2.2	-3.1
Bone volume	2.5	4.2	4.2	-2.1	2.1	-2.0
Bone: connectivity density	2.9	4.6	4.6	-2.2	2.1	-2.1
Bone: cortical apparent density	0.1	0.1	0.3	-0.0	0.0	-0.6
Bone: cortical area	0.4	0.5	1.6	-0.0	0.0	-1.3
Bone: cortical porosity	0.7	0.7	1.0	-1.0	1.0	-0.4
Bone: cortical porosity	0.7	0.8	0.8	-0.9	0.9	-0.8
Bone: cortical thickness	1.1	1.9	4.3	0.8	-0.8	-2.1
Bone: cortical thickness	0.6	0.7	1.0	1.0	-1.0	-0.5
Bone: cortical tissue density	0.1	0.1	0.4	0.0	-0.0	-0.6
Bone: elastic displacement	3.2	3.6	4.1	2.0	-2.0	1.6
Bone: elastic work	0.5	0.6	0.8	0.9	-0.9	-0.5
Bone: endosteal estimation	0.8	1.8	2.3	-1.5	1.5	0.9
Bone: endosteal perimeter	0.8	1.7	2.1	-1.4	1.4	1.0
Bone: final force	1.6	2.7	5.9	-1.0	1.0	-2.4
Bone: final moment	1.4	2.4	5.2	-1.0	1.0	-2.3
Bone: marrow area	0.9	1.9	2.4	-1.6	1.6	1.0
Bone: maximum diameter	0.1	0.2	0.5	0.1	-0.1	-0.7
Bone: maximum force	3.6	6.3	8.8	-2.2	2.2	-3.0
Bone: maximum moment	3.1	5.4	7.5	-2.1	2.1	-2.7
Bone: minimum diameter	1.6	3.0	4.3	-2.1	2.1	0.6
Bone: periosteal estimation	0.2	0.5	0.7	-0.8	0.9	-0.3
Bone: periosteal perimeter	0.3	0.5	0.5	-0.7	0.7	-0.6
Bone: post-yield work	10.0	13.5	18.8	-4.3	4.3	-1.8
Bone: stiffness	3.5	5.6	6.9	-2.2	2.2	-2.6
Bone: tissue strength	0.1	0.1	0.1	-0.3	0.3	-0.3
Bone: trabecular number	1.5	2.4	2.9	-1.7	1.7	-1.2
Bone: trabecular spacing	0.3	0.4	0.6	0.6	-0.6	0.7
Bone: trabecular thickness	0.5	0.7	0.9	-0.9	0.9	0.5
Bone: trabecular tissue density	1.9	2.7	5.4	1.2	-1.1	2.3
Breakpoint value in progressive ratio session	1.9	2.1	5.1	-0.8	0.8	-2.3
Distance traveled before self-admin	0.4	0.4	1.0	-0.4	0.4	-1.0
Distance traveled after self-admin	0.2	0.2	0.4	-0.2	0.3	-0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.2	-0.2	-0.4
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.4	-0.4	-0.6
Extinction: sum of active levers before priming	4.6	4.6	7.1	-1.8	1.8	-2.7
Active lever presses in extinction session 6	1.1	1.1	2.7	0.5	-0.5	-1.6
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	-0.3	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.4	-0.4	0.3
Time in closed arm before self-admin	0.1	0.2	0.2	-0.4	0.4	-0.4
Time in closed arm after self-admin	0.1	0.1	0.1	-0.4	0.4	0.1
Time in open arm before self-admin	0.5	0.5	1.3	0.3	-0.3	1.1
Time in open arm after self-admin	0.7	0.7	0.9	0.9	-0.9	0.6
Sum of active levers in priming session hrs 5-6	1.6	1.5	2.0	1.2	-1.1	-1.4
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.0	-1.0	1.0	-0.9
Time to tail flick, vehicle, after self-admin	1.3	1.4	1.4	-1.2	1.2	-1.2
Time to tail flick, test, before self-admin	1.0	1.0	1.2	-1.1	1.1	0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.5	-0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.3	-0.5	0.5	-0.6
Delta time to tail flick, test, before/after SA	2.4	2.1	2.9	1.7	-1.7	-0.8
Ambulatory time before self-admin	0.4	0.4	0.9	-0.4	0.4	-0.9
Ambulatory time after self-admin	0.5	0.5	0.8	-0.9	0.9	-0.1
Total heroin consumption	2.9	3.4	8.3	-1.0	1.0	-2.9
Area under the delay curve	0.4	0.4	0.6	-0.8	0.8	0.2
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	-0.6	0.6	0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.4	0.4	0.7
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	-0.2	0.2	0.3
Delay disc. indifference point, 24s delay	0.3	0.2	0.3	0.5	-0.5	0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.4	0.4	0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	0.3	0.3
Delay discount exponential model param	0.3	0.3	0.4	0.6	-0.6	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	-0.5	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.2	0.2	-0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	-0.5	0.5	0.2
Time >=10cm from walls, locomotor time 1	1.5	1.5	2.2	-1.5	1.5	0.3
Bouts of movement, locomotor time 1	0.6	0.6	1.8	-0.1	0.1	-1.4
Total resting periods, locomotor time 1	0.5	0.6	1.5	-0.3	0.3	-1.2
Rest time, locomotor task time 1	1.4	1.5	1.7	1.2	-1.2	1.3
Distance moved, locomotor task time 1	0.8	0.9	1.3	-1.1	1.1	-0.5
Vertical activity count, locomotor time 1	0.5	0.5	1.5	0.2	-0.2	1.2
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.2	-0.4	0.4	-0.4
Bouts of movement, locomotor time 2	0.4	0.4	0.7	-0.5	0.5	-0.9
Total resting periods, locomotor time 2	0.4	0.4	0.4	-0.6	0.6	-0.7
Rest time, locomotor task time 2	1.0	1.1	3.0	0.4	-0.4	1.7
Distance moved, locomotor task time 2	0.4	0.5	1.4	-0.0	0.0	-1.2
Vertical activity count, locomotor time 2	1.3	1.4	2.0	1.4	-1.4	0.5
Weight adjusted by age	1.0	1.1	3.2	-0.1	0.1	-1.8
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.1	-1.0	1.0	-0.0
Locomotion in novel chamber	1.9	2.4	5.5	0.9	-0.9	2.3
Locomotion in novel chamber post-restriction	1.2	1.4	3.7	0.5	-0.5	1.9
Progressive ratio	4.6	5.3	6.0	-2.4	2.4	-2.0
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	-0.1	-0.2
Seeking ratio, punishment vs. effort	3.3	4.0	4.0	2.0	-2.0	2.0
Run reversals in cocaine runway, females	2.3	2.3	3.2	-1.8	1.8	-0.7
Run reversals in cocaine runway, males	2.5	2.5	3.4	1.8	-1.8	0.8
Latency to leave start box in cocaine runway	1.0	1.1	1.6	-1.3	1.3	-0.2
Latency to leave start box in cocaine runway, F	0.6	0.7	1.0	-1.0	1.0	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.3	-0.1
Cd content in liver	1.4	1.5	1.5	1.2	-1.2	1.2
Co content in liver	2.7	3.2	3.4	1.8	-1.8	1.8
Cu content in liver	0.6	0.7	0.7	-0.8	0.8	-0.8
Fe content in liver	0.1	0.1	0.1	0.3	-0.3	-0.4
K content in liver	2.9	2.9	3.1	-1.8	1.8	-1.6
Mg content in liver	3.4	3.5	5.0	-2.2	2.2	-0.6
Mn content in liver	1.3	1.5	4.1	-0.5	0.5	-2.0
Na content in liver	0.5	0.6	1.5	0.3	-0.3	-1.2
Rb content in liver	0.8	1.1	1.7	-0.8	0.9	1.3
Se content in liver	0.1	0.2	0.2	-0.4	0.4	-0.3
Sr content in liver	1.4	1.3	2.6	0.8	-0.8	-1.6
Zn content in liver	1.1	1.2	1.9	-0.9	0.9	-1.4