Best TWAS P=1.754608e-07 · Best GWAS P=9.37038e-07 conditioned to 6.740244e-77
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Liver | Gde1 | gene expression | ENSRNOG00000050445 | 0.32 | 0.15 | lasso | 36 | 0.20 | 4.8e-22 | -4.6 | -5.2 | 1.8e-07 | 0.86 | 0.53 | 0.47 | TRUE |
2 | Liver | RGD1559600 | intron excision ratio | chr1:173974388:173987413 | 0.53 | 0.01 | lasso | 2 | 0.01 | 3.5e-02 | -4.5 | -5.2 | 2.0e-07 | 0.90 | 0.25 | 0.38 | FALSE |
3 | PL2 | Rps15a | isoform ratio | ENSRNOT00000092282 | 0.07 | 0.03 | blup | 2643 | 0.07 | 1.8e-04 | -4.0 | -5.2 | 2.1e-07 | 0.78 | 0.67 | 0.30 | FALSE |
4 | PL2 | Rps15a | isoform ratio | ENSRNOT00000092513 | 0.07 | 0.03 | blup | 2643 | 0.07 | 1.7e-04 | -4.0 | 5.2 | 1.9e-07 | -0.79 | 0.64 | 0.33 | FALSE |
5 | PL2 | Syt17 | intron excision ratio | chr1:172757188:172757416 | 0.06 | 0.03 | blup | 2590 | 0.04 | 2.5e-03 | -4.5 | -5.1 | 2.9e-07 | 0.78 | 0.52 | 0.37 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.