Best TWAS P=1.668169e-07 · Best GWAS P=9.37038e-07 conditioned to 2.491888e-65
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver | Gde1 | gene expression | ENSRNOG00000050445 | 0.32 | 0.15 | lasso | 36 | 0.20 | 4.8e-22 | -4.6 | -5.2 | 1.8e-07 | 0.86 | 0.53 | 0.47 | FALSE |
| 2 | Liver | RGD1559600 | intron excision ratio | chr1:173974388:173987413 | 0.53 | 0.01 | lasso | 2 | 0.01 | 3.5e-02 | -4.5 | -5.2 | 2.0e-07 | 0.90 | 0.25 | 0.38 | FALSE |
| 3 | PL | Rps15a | isoform ratio | ENSRNOT00000092513 | 0.04 | 0.03 | blup | 2641 | 0.04 | 1.0e-03 | -4.4 | 5.1 | 3.4e-07 | -0.71 | 0.69 | 0.29 | FALSE |
| 4 | PL | Rps15a | intron excision ratio | chr1:172426036:172426864 | 0.05 | 0.02 | blup | 2641 | 0.03 | 2.0e-03 | -4.4 | 5.2 | 1.7e-07 | -0.84 | 0.58 | 0.41 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.