| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000053405 | 0.0800 | 0.0670 | 2.5e-08 | 0.053 | 0.061 | 0.054 | 0.054 | 1.5e-06 | 2.3e-07 | 1.2e-06 | 1.2e-06 |
| 2 | Adipose | isoform ratio | ENSRNOT00000083926 | 0.4200 | 0.2100 | 7.6e-04 | 0.012 | 0.019 | 0.028 | 0.029 | 1.6e-02 | 2.9e-03 | 4.2e-04 | 3.4e-04 |
| 3 | Adipose | mRNA stability | ENSRNOG00000053405 | 0.0410 | 0.0380 | 1.4e-04 | 0.016 | 0.030 | 0.016 | 0.017 | 6.3e-03 | 2.7e-04 | 5.3e-03 | 4.9e-03 |
| 4 | BLA | gene expression | ENSRNOG00000053405 | 0.5726 | 0.2089 | 0.0e+00 | 0.354 | 0.121 | 0.390 | 0.161 | 9.0e-20 | 5.3e-07 | 3.7e-22 | 5.6e-09 |
| 5 | Brain | gene expression | ENSRNOG00000053405 | 0.1700 | 0.1100 | 0.0e+00 | 0.184 | 0.187 | 0.179 | 0.187 | 8.0e-17 | 4.6e-17 | 2.3e-16 | 4.4e-17 |
| 6 | Brain | mRNA stability | ENSRNOG00000053405 | 0.0666 | 0.0493 | 2.2e-07 | 0.065 | 0.074 | 0.056 | 0.067 | 1.2e-06 | 2.0e-07 | 6.8e-06 | 7.6e-07 |
| 7 | IL | isoform ratio | ENSRNOT00000111323 | 0.1780 | 0.1420 | 5.7e-04 | 0.096 | 0.117 | 0.075 | 0.082 | 2.7e-03 | 9.5e-04 | 7.3e-03 | 5.3e-03 |
| 8 | IL | intron excision ratio | chr7:128813961:128814331 | 0.1700 | 0.1360 | 8.1e-04 | 0.100 | 0.107 | 0.078 | 0.094 | 2.2e-03 | 1.6e-03 | 6.3e-03 | 2.9e-03 |
| 9 | IL | intron excision ratio | chr7:128814428:128815307 | 0.1300 | 0.1190 | 5.4e-03 | 0.064 | 0.070 | 0.061 | 0.054 | 1.2e-02 | 9.2e-03 | 1.4e-02 | 2.0e-02 |
| 10 | LHb | gene expression | ENSRNOG00000053405 | 0.1489 | 0.1271 | 4.5e-03 | 0.075 | 0.075 | 0.048 | 0.068 | 7.5e-03 | 7.7e-03 | 2.8e-02 | 1.1e-02 |
| 11 | Liver | gene expression | ENSRNOG00000053405 | 0.4900 | 0.1500 | 0.0e+00 | 0.433 | 0.451 | 0.437 | 0.439 | 1.6e-52 | 2.6e-55 | 3.8e-53 | 2.6e-53 |
| 12 | Liver | mRNA stability | ENSRNOG00000053405 | 0.0813 | 0.0666 | 1.1e-08 | 0.052 | 0.063 | 0.055 | 0.054 | 1.7e-06 | 1.5e-07 | 9.5e-07 | 1.1e-06 |
| 13 | NAcc | gene expression | ENSRNOG00000053405 | 0.2200 | 0.1400 | 2.1e-15 | 0.166 | 0.186 | 0.183 | 0.182 | 2.0e-12 | 7.6e-14 | 1.3e-13 | 1.5e-13 |
| 14 | NAcc | intron excision ratio | chr7:128838537:128839475 | 0.0381 | 0.0397 | 5.2e-03 | 0.016 | 0.012 | -0.002 | 0.009 | 2.1e-02 | 4.2e-02 | 5.4e-01 | 6.3e-02 |
| 15 | OFC | gene expression | ENSRNOG00000053405 | 0.3068 | 0.1745 | 3.2e-06 | 0.162 | 0.172 | 0.159 | 0.130 | 1.2e-04 | 6.8e-05 | 1.4e-04 | 5.5e-04 |
| 16 | PL | alternative TSS | ENSRNOT00000083926 | 0.0480 | 0.0450 | 8.6e-04 | 0.026 | 0.027 | 0.017 | 0.016 | 4.2e-03 | 3.6e-03 | 1.6e-02 | 2.1e-02 |
| 17 | PL | alternative TSS | ENSRNOT00000106326 | 0.0520 | 0.0490 | 5.4e-04 | 0.028 | 0.028 | 0.021 | 0.021 | 3.3e-03 | 2.9e-03 | 8.9e-03 | 9.8e-03 |
| 18 | PL | alternative TSS | ENSRNOT00000083926 | 0.0490 | 0.0480 | 9.7e-04 | 0.017 | 0.026 | 0.015 | 0.014 | 1.7e-02 | 4.5e-03 | 2.4e-02 | 2.8e-02 |
| 19 | PL | alternative TSS | ENSRNOT00000106326 | 0.0500 | 0.0490 | 9.2e-04 | 0.025 | 0.025 | 0.017 | 0.016 | 5.1e-03 | 5.2e-03 | 1.7e-02 | 1.9e-02 |
| 20 | PL | gene expression | ENSRNOG00000053405 | 0.4213 | 0.2127 | 0.0e+00 | 0.312 | 0.300 | 0.327 | 0.309 | 3.7e-24 | 4.0e-23 | 1.7e-25 | 5.9e-24 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bone: stiffness | 15.4 | 24.3 | 25.7 | -4.9 | -5.1 | -5.0 | -5.0 | -4.8 | -5.0 | 4.9 | -4.9 | 4.9 | -5.1 | -4.9 | -5.0 | -4.9 | -4.7 | -4.9 | 5.0 | -5.0 | 5.0 | -4.8 | -5.0 |
| Bone: maximum force | 12.5 | 21.8 | 22.9 | -4.7 | -4.8 | -4.7 | -4.7 | -4.7 | -4.7 | 4.7 | -4.7 | 4.7 | -4.7 | -4.6 | -4.7 | -4.7 | -4.4 | -4.6 | 4.7 | -4.7 | 4.7 | -4.7 | -4.6 |
| Bone: maximum moment | 12.5 | 21.7 | 22.8 | -4.7 | -4.8 | -4.7 | -4.7 | -4.7 | -4.7 | 4.7 | -4.7 | 4.7 | -4.7 | -4.6 | -4.7 | -4.6 | -4.4 | -4.6 | 4.7 | -4.7 | 4.7 | -4.7 | -4.6 |
| Bone: periosteal estimation | 12.0 | 24.5 | 25.7 | -5.0 | -5.1 | -5.0 | -4.9 | -4.9 | -5.0 | 5.0 | -4.9 | 4.9 | -5.0 | -4.9 | -5.0 | -4.9 | -4.8 | -4.9 | 5.0 | -5.0 | 5.0 | -4.9 | -4.9 |
| Bone: periosteal perimeter | 11.0 | 18.3 | 18.8 | -4.3 | -4.3 | -4.3 | -4.3 | -4.2 | -4.3 | 4.3 | -4.3 | 4.3 | -4.3 | -4.3 | -4.3 | -4.3 | -4.2 | -4.3 | 4.3 | -4.3 | 4.3 | -4.2 | -4.1 |
| Intraocular pressure | 10.5 | 14.8 | 17.3 | 3.9 | 3.9 | 3.9 | 4.2 | 4.1 | 3.9 | -3.9 | 3.8 | -3.7 | 4.0 | 4.0 | 3.9 | 3.6 | 3.2 | 3.9 | -4.0 | 4.0 | -4.0 | 3.9 | 3.0 |
| Bone surface | 10.2 | 18.0 | 18.3 | -4.2 | -4.2 | -4.3 | -4.3 | -4.3 | -4.3 | 4.2 | -4.2 | 4.2 | -4.2 | -4.2 | -4.3 | -4.3 | -4.2 | -4.2 | 4.3 | -4.3 | 4.3 | -4.2 | -4.2 |
| Bone: final moment | 10.1 | 16.6 | 17.7 | -4.1 | -4.2 | -4.1 | -4.1 | -4.1 | -4.1 | 4.1 | -4.1 | 4.1 | -4.1 | -4.0 | -4.1 | -4.1 | -3.9 | -4.0 | 4.1 | -4.1 | 4.1 | -4.1 | -4.2 |
| Bone: cortical area | 10.0 | 15.1 | 18.2 | -3.9 | -4.1 | -3.9 | -3.9 | -3.8 | -3.9 | 3.9 | -3.9 | 3.9 | -3.9 | -3.8 | -3.9 | -3.9 | -3.7 | -3.8 | 3.9 | -3.9 | 3.9 | -3.8 | -4.3 |
| Bone: final force | 10.0 | 16.4 | 17.4 | -4.1 | -4.2 | -4.1 | -4.1 | -4.0 | -4.1 | 4.0 | -4.0 | 4.0 | -4.1 | -4.0 | -4.1 | -4.0 | -3.8 | -4.0 | 4.1 | -4.1 | 4.1 | -4.1 | -4.2 |
| Reaction time omissions | 9.6 | 12.9 | 14.5 | 3.5 | 3.8 | 3.6 | 3.6 | 3.5 | 3.6 | -3.6 | 3.5 | -3.5 | 3.8 | 3.6 | 3.7 | 3.6 | 3.6 | 3.6 | -3.7 | 3.7 | -3.7 | 3.5 | 3.4 |
| Reaction time mean minus median | 9.2 | 12.0 | 13.2 | 3.4 | 3.5 | 3.5 | 3.6 | 3.5 | 3.5 | -3.5 | 3.5 | -3.5 | 3.5 | 3.5 | 3.5 | 3.5 | 3.6 | 3.5 | -3.5 | 3.5 | -3.5 | 3.6 | 2.6 |
| Social responses | 9.1 | 11.8 | 13.8 | 3.4 | 3.4 | 3.4 | 3.3 | 3.4 | 3.4 | -3.4 | 3.4 | -3.5 | 3.2 | 3.4 | 3.4 | 3.5 | 3.7 | 3.4 | -3.4 | 3.4 | -3.4 | 3.6 | 3.6 |
| Bone: post-yield work | 8.4 | 11.4 | 12.1 | -3.5 | -3.2 | -3.4 | -3.5 | -3.5 | -3.5 | 3.4 | -3.5 | 3.5 | -3.5 | -3.4 | -3.4 | -3.4 | -3.2 | -3.5 | 3.4 | -3.4 | 3.4 | -3.4 | -2.5 |
| Length without tail | 8.2 | 17.8 | 19.1 | -4.3 | -4.2 | -4.3 | -4.4 | -4.4 | -4.3 | 4.3 | -4.2 | 4.2 | -4.3 | -4.3 | -4.2 | -4.2 | -4.1 | -4.3 | 4.3 | -4.3 | 4.3 | -4.0 | -3.8 |
| Bone: minimum diameter | 7.8 | 14.4 | 15.7 | -3.8 | -4.0 | -3.8 | -3.8 | -3.8 | -3.8 | 3.8 | -3.8 | 3.8 | -3.8 | -3.7 | -3.8 | -3.8 | -3.6 | -3.7 | 3.8 | -3.8 | 3.8 | -3.8 | -3.8 |
| Bone: apparent density | 7.6 | 12.6 | 15.8 | -3.5 | -3.6 | -3.6 | -3.6 | -3.5 | -3.6 | 3.5 | -3.5 | 3.5 | -3.5 | -3.4 | -3.6 | -3.5 | -3.3 | -3.4 | 3.6 | -3.6 | 3.6 | -3.5 | -4.0 |
| Bone: marrow area | 7.6 | 16.3 | 16.8 | -4.1 | -4.0 | -4.1 | -4.1 | -4.1 | -4.1 | 4.1 | -4.1 | 4.1 | -4.1 | -4.1 | -4.1 | -4.0 | -4.1 | -4.1 | 4.1 | -4.1 | 4.1 | -4.1 | -3.4 |
| Bone: endosteal estimation | 7.5 | 16.2 | 16.7 | -4.0 | -4.0 | -4.1 | -4.0 | -4.1 | -4.1 | 4.1 | -4.0 | 4.0 | -4.0 | -4.0 | -4.1 | -4.0 | -4.0 | -4.1 | 4.1 | -4.1 | 4.1 | -4.0 | -3.4 |
| Body weight | 7.4 | 31.2 | 35.0 | -5.5 | -5.9 | -5.6 | -5.8 | -5.6 | -5.6 | 5.6 | -5.4 | 5.4 | -5.8 | -5.6 | -5.7 | -5.4 | -5.2 | -5.5 | 5.7 | -5.7 | 5.7 | -5.3 | -5.8 |
| Cocaine response before conditioning | 6.9 | 8.4 | 9.2 | 2.9 | 3.0 | 2.9 | 3.0 | 2.9 | 2.9 | -2.9 | 2.9 | -2.8 | 2.9 | 3.0 | 2.9 | 2.8 | 2.8 | 3.0 | -2.9 | 2.9 | -2.9 | 2.9 | 2.7 |
| Bone: endosteal perimeter | 6.9 | 14.1 | 14.6 | -3.8 | -3.8 | -3.8 | -3.8 | -3.8 | -3.8 | 3.8 | -3.8 | 3.8 | -3.8 | -3.7 | -3.8 | -3.7 | -3.7 | -3.8 | 3.8 | -3.8 | 3.8 | -3.8 | -3.4 |
| Std. dev. reaction times | 6.8 | 9.3 | 10.3 | 3.0 | 3.0 | 3.1 | 3.2 | 3.0 | 3.0 | -3.1 | 3.0 | -3.0 | 3.2 | 3.1 | 3.1 | 3.1 | 3.2 | 3.1 | -3.1 | 3.1 | -3.1 | 3.2 | 2.1 |
| Reaction time mean minus median AUC | 6.7 | 8.6 | 9.9 | 2.9 | 2.9 | 3.0 | 3.1 | 2.9 | 2.9 | -3.0 | 2.9 | -2.9 | 3.1 | 3.0 | 3.0 | 3.0 | 3.1 | 2.9 | -3.0 | 3.0 | -3.0 | 3.1 | 1.9 |
| Bone volume | 6.6 | 11.2 | 12.5 | -3.3 | -3.4 | -3.4 | -3.4 | -3.3 | -3.4 | 3.3 | -3.3 | 3.3 | -3.3 | -3.3 | -3.4 | -3.3 | -3.2 | -3.3 | 3.4 | -3.4 | 3.4 | -3.3 | -3.5 |
| Extensor digitorum longus weight | 6.2 | 25.1 | 27.3 | -5.1 | -4.8 | -5.1 | -5.2 | -5.2 | -5.1 | 5.1 | -5.1 | 5.0 | -5.0 | -5.1 | -5.1 | -5.0 | -4.8 | -5.1 | 5.1 | -5.1 | 5.1 | -5.2 | -3.5 |
| Tibia length | 6.1 | 17.1 | 22.3 | -4.1 | -4.4 | -4.1 | -4.0 | -4.0 | -4.1 | 4.1 | -4.1 | 4.1 | -4.0 | -4.0 | -4.2 | -4.2 | -4.2 | -4.0 | 4.1 | -4.1 | 4.1 | -4.0 | -4.7 |
| Bone: connectivity density | 5.8 | 9.1 | 11.1 | -3.0 | -3.0 | -3.0 | -3.1 | -3.0 | -3.0 | 3.0 | -3.0 | 3.0 | -3.0 | -3.0 | -3.0 | -3.0 | -2.8 | -3.0 | 3.0 | -3.0 | 3.0 | -3.0 | -3.3 |
| Locomotion distance, session 3 | 5.1 | 5.5 | 5.9 | 2.4 | 2.4 | 2.4 | 2.4 | 2.4 | 2.4 | -2.4 | 2.4 | -2.4 | 2.4 | 2.3 | 2.4 | 2.3 | 2.0 | 2.4 | -2.4 | 2.4 | -2.4 | 2.4 | 2.1 |
| BMI with tail | 5.0 | 16.3 | 27.8 | -4.0 | -4.5 | -4.0 | -4.3 | -3.7 | -4.0 | 4.0 | -3.9 | 3.9 | -4.1 | -4.0 | -4.0 | -3.9 | -3.6 | -3.9 | 4.0 | -4.0 | 4.1 | -3.4 | -5.3 |
| Delay discounting water rate 6 sec | 4.9 | 7.1 | 9.6 | -2.7 | -2.7 | -2.6 | -2.5 | -2.9 | -2.6 | 2.7 | -2.7 | 2.7 | -2.7 | -2.7 | -2.6 | -2.7 | -3.1 | -2.7 | 2.6 | -2.6 | 2.6 | -2.9 | -1.8 |
| Bone: elastic displacement | 4.9 | 5.6 | 6.3 | 2.4 | 2.4 | 2.4 | 2.5 | 2.4 | 2.4 | -2.4 | 2.3 | -2.3 | 2.5 | 2.4 | 2.4 | 2.3 | 2.1 | 2.4 | -2.4 | 2.4 | -2.4 | 2.4 | 2.1 |
| Bone: maximum diameter | 4.8 | 8.8 | 9.6 | -3.0 | -3.1 | -3.0 | -3.0 | -2.8 | -3.0 | 3.0 | -3.0 | 3.0 | -3.1 | -2.9 | -3.0 | -2.9 | -2.7 | -3.0 | 3.0 | -3.0 | 3.0 | -2.8 | -3.1 |
| Delay discounting water rate 0 sec | 4.7 | 7.5 | 8.3 | -2.8 | -2.8 | -2.7 | -2.7 | -2.7 | -2.7 | 2.8 | -2.8 | 2.8 | -2.8 | -2.8 | -2.7 | -2.8 | -2.9 | -2.8 | 2.7 | -2.7 | 2.7 | -2.5 | -2.6 |
| Post-drug Anxiety | 4.4 | 4.9 | 6.3 | -2.2 | -2.1 | -2.2 | -2.1 | -2.0 | -2.2 | 2.2 | -2.3 | 2.3 | -2.1 | -2.2 | -2.2 | -2.3 | -2.5 | -2.2 | 2.2 | -2.2 | 2.2 | -2.2 | -2.3 |
| Bone: cortical thickness | 4.1 | 6.9 | 9.5 | -2.6 | -2.7 | -2.6 | -2.6 | -2.5 | -2.6 | 2.6 | -2.6 | 2.6 | -2.6 | -2.5 | -2.6 | -2.6 | -2.5 | -2.6 | 2.6 | -2.6 | 2.6 | -2.5 | -3.1 |
| Bone: trabecular number | 4.1 | 6.4 | 8.3 | -2.5 | -2.5 | -2.5 | -2.6 | -2.5 | -2.6 | 2.5 | -2.5 | 2.5 | -2.5 | -2.5 | -2.5 | -2.5 | -2.4 | -2.5 | 2.5 | -2.5 | 2.5 | -2.5 | -2.9 |
| Delay disc. indifference point, 8s delay | 4.1 | 4.2 | 6.8 | -2.0 | -2.0 | -2.0 | -2.1 | -2.3 | -2.0 | 2.1 | -2.0 | 2.0 | -2.0 | -2.1 | -2.0 | -2.1 | -2.2 | -2.1 | 2.0 | -2.0 | 2.0 | -2.6 | -1.2 |
| Delta time in open arm before/after self-admin | 3.9 | 3.7 | 8.7 | 1.9 | 2.0 | 1.9 | 1.9 | 1.5 | 1.9 | -1.9 | 1.8 | -1.8 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | -1.9 | 1.9 | -1.9 | 1.5 | 2.9 |
| Ambulatory time before self-admin | 3.9 | 4.1 | 4.7 | 2.0 | 2.0 | 2.0 | 2.1 | 2.0 | 2.0 | -2.0 | 2.0 | -2.0 | 2.0 | 2.1 | 2.0 | 2.0 | 2.0 | 2.0 | -2.0 | 2.0 | -2.0 | 1.8 | 2.2 |
| Delay discounting water rate 12 sec | 3.7 | 5.6 | 6.7 | -2.4 | -2.3 | -2.4 | -2.3 | -2.4 | -2.4 | 2.4 | -2.3 | 2.3 | -2.5 | -2.4 | -2.4 | -2.4 | -2.6 | -2.4 | 2.4 | -2.4 | 2.4 | -2.5 | -1.7 |
| Reaction time premature initiation rate | 3.7 | 4.9 | 9.7 | 2.2 | 2.5 | 2.2 | 2.2 | 1.9 | 2.2 | -2.2 | 2.1 | -2.1 | 2.4 | 2.1 | 2.3 | 2.1 | 1.9 | 2.1 | -2.3 | 2.3 | -2.3 | 1.7 | 3.1 |
| Delay discounting water rate 24 sec | 3.6 | 5.0 | 7.5 | -2.2 | -2.3 | -2.2 | -2.1 | -2.1 | -2.2 | 2.3 | -2.3 | 2.3 | -2.1 | -2.2 | -2.2 | -2.4 | -2.7 | -2.2 | 2.2 | -2.2 | 2.1 | -2.1 | -2.2 |
| Intermitt. access day 1 inactive lever presses | 3.5 | 3.7 | 5.9 | 1.9 | 2.0 | 1.9 | 2.0 | 2.1 | 1.9 | -1.9 | 1.8 | -1.8 | 1.9 | 1.9 | 1.9 | 1.9 | 1.8 | 1.9 | -1.9 | 1.9 | -1.9 | 1.9 | 2.4 |
| Total resting periods, locomotor time 2 | 3.5 | 3.8 | 4.0 | -1.9 | -2.0 | -2.0 | -2.0 | -1.9 | -2.0 | 2.0 | -1.9 | 1.9 | -2.0 | -1.9 | -2.0 | -1.9 | -1.9 | -1.9 | 2.0 | -2.0 | 2.0 | -2.0 | -1.6 |
| Bouts of movement, locomotor time 2 | 3.4 | 3.6 | 3.8 | -1.9 | -1.9 | -1.9 | -1.9 | -1.8 | -1.9 | 1.9 | -1.9 | 1.9 | -1.9 | -1.9 | -1.9 | -1.9 | -1.9 | -1.9 | 1.9 | -1.9 | 1.9 | -1.9 | -1.7 |
| Indifference point function ln k | 3.3 | 4.6 | 5.8 | -2.1 | -2.4 | -2.2 | -2.2 | -2.1 | -2.2 | 2.1 | -2.0 | 2.0 | -2.2 | -2.1 | -2.2 | -2.0 | -2.0 | -2.1 | 2.2 | -2.2 | 2.2 | -2.0 | -2.4 |
| Indifference point function log k | 3.3 | 4.6 | 5.8 | -2.1 | -2.4 | -2.2 | -2.2 | -2.1 | -2.2 | 2.1 | -2.0 | 2.0 | -2.2 | -2.1 | -2.2 | -2.0 | -2.0 | -2.1 | 2.2 | -2.2 | 2.2 | -2.0 | -2.4 |
| Progressive ratio test 1 active lever presses | 3.3 | 3.5 | 4.1 | 1.9 | 1.9 | 1.9 | 1.9 | 2.0 | 1.9 | -1.9 | 1.8 | -1.8 | 2.0 | 1.9 | 1.9 | 1.8 | 1.8 | 1.9 | -1.9 | 1.9 | -1.9 | 1.7 | 1.8 |
| Delay discounting time to switch 0 sec | 3.2 | 4.9 | 5.5 | 2.2 | 2.3 | 2.2 | 2.3 | 2.1 | 2.2 | -2.2 | 2.2 | -2.2 | 2.3 | 2.2 | 2.2 | 2.2 | 2.2 | 2.2 | -2.2 | 2.2 | -2.2 | 2.1 | 2.3 |
| Delay discounting total patch changes 18 sec | 3.1 | 4.1 | 6.9 | 2.0 | 2.1 | 2.0 | 1.9 | 1.8 | 2.0 | -2.0 | 2.0 | -1.9 | 2.0 | 2.0 | 2.0 | 2.0 | 1.9 | 2.0 | -2.0 | 2.0 | -2.0 | 2.0 | 2.6 |
| Reaction time num false alarms AUC | 3.1 | 4.4 | 5.0 | 2.1 | 2.1 | 2.1 | 2.1 | 2.2 | 2.1 | -2.1 | 2.1 | -2.1 | 2.0 | 2.0 | 2.1 | 2.1 | 2.2 | 2.1 | -2.1 | 2.1 | -2.1 | 2.0 | 1.8 |
| Progressive ratio test 1 breakpoint | 3.1 | 3.2 | 3.8 | 1.8 | 1.7 | 1.8 | 1.8 | 2.0 | 1.8 | -1.8 | 1.7 | -1.7 | 1.9 | 1.8 | 1.8 | 1.8 | 1.8 | 1.8 | -1.8 | 1.8 | -1.8 | 1.8 | 1.6 |
| Condit. Reinf. inactive responses | 3.1 | 3.7 | 6.5 | 1.9 | 1.9 | 1.9 | 1.8 | 1.7 | 1.9 | -1.9 | 2.0 | -2.0 | 1.8 | 1.9 | 1.9 | 2.0 | 1.9 | 1.9 | -1.9 | 1.9 | -1.8 | 1.7 | 2.5 |
| Locomotion velocity, session 3 | 3.0 | 3.5 | 3.9 | 1.9 | 1.9 | 1.9 | 1.8 | 2.0 | 1.9 | -1.9 | 1.9 | -1.9 | 1.8 | 1.8 | 1.9 | 1.9 | 1.7 | 1.8 | -1.9 | 1.9 | -1.9 | 2.0 | 1.7 |
| Right kidney weight | 2.9 | 8.3 | 9.7 | -2.9 | -3.1 | -2.9 | -3.0 | -3.1 | -2.9 | 2.9 | -2.8 | 2.8 | -3.0 | -2.9 | -2.9 | -2.7 | -2.3 | -2.9 | 3.0 | -3.0 | 3.0 | -2.9 | -2.6 |
| Progressive ratio test 2 inactive lever presses | 2.9 | 3.4 | 4.2 | 1.8 | 1.7 | 1.8 | 1.8 | 2.1 | 1.8 | -1.8 | 1.8 | -1.9 | 1.8 | 1.8 | 1.8 | 1.9 | 1.9 | 1.8 | -1.8 | 1.8 | -1.8 | 2.0 | 1.8 |
| Light reinforcement 1 | 2.8 | 5.2 | 6.1 | 2.3 | 2.2 | 2.3 | 2.2 | 2.2 | 2.3 | -2.3 | 2.3 | -2.3 | 2.5 | 2.3 | 2.2 | 2.2 | 2.2 | 2.3 | -2.3 | 2.3 | -2.3 | 2.1 | 2.4 |
| Bone: cortical porosity | 2.8 | 3.0 | 3.8 | 1.7 | 1.9 | 1.7 | 1.8 | 1.9 | 1.7 | -1.7 | 1.6 | -1.6 | 1.7 | 1.8 | 1.7 | 1.6 | 1.6 | 1.7 | -1.7 | 1.7 | -1.7 | 1.9 | 1.5 |
| Locomotor testing distance | 2.7 | 4.5 | 5.9 | 2.1 | 1.9 | 2.1 | 2.2 | 2.2 | 2.1 | -2.2 | 2.1 | -2.1 | 2.1 | 2.2 | 2.1 | 2.2 | 2.3 | 2.1 | -2.1 | 2.1 | -2.1 | 2.4 | 1.3 |
| Locomotion distance, session 1 | 2.7 | 3.5 | 4.0 | 1.9 | 1.8 | 1.9 | 1.8 | 1.8 | 1.9 | -1.9 | 1.9 | -1.9 | 1.9 | 1.8 | 1.9 | 2.0 | 2.0 | 1.9 | -1.9 | 1.9 | -1.9 | 1.8 | 1.5 |
| Tibialis anterior weight | 2.6 | 9.1 | 10.0 | -3.0 | -3.0 | -3.1 | -3.1 | -3.1 | -3.0 | 3.1 | -3.0 | 3.0 | -3.1 | -3.1 | -3.1 | -3.0 | -2.9 | -3.1 | 3.1 | -3.1 | 3.1 | -3.2 | -2.0 |
| Locomotor testing rearing | 2.6 | 4.1 | 5.5 | 2.1 | 1.8 | 2.0 | 2.0 | 1.9 | 2.0 | -2.1 | 2.1 | -2.1 | 2.1 | 2.1 | 2.0 | 2.2 | 2.3 | 2.1 | -2.0 | 2.0 | -2.0 | 2.1 | 1.6 |
| Latency to leave start box in cocaine runway, M | 2.6 | 2.5 | 4.3 | -1.5 | -1.6 | -1.5 | -1.5 | -1.8 | -1.5 | 1.5 | -1.5 | 1.5 | -1.5 | -1.6 | -1.5 | -1.6 | -1.7 | -1.6 | 1.5 | -1.5 | 1.5 | -2.1 | -1.0 |
| Intermittent access terminal intake (last 3 days) | 2.5 | 2.7 | 3.2 | 1.7 | 1.5 | 1.7 | 1.5 | 1.6 | 1.7 | -1.7 | 1.7 | -1.7 | 1.8 | 1.6 | 1.7 | 1.7 | 1.7 | 1.7 | -1.6 | 1.6 | -1.6 | 1.5 | 1.6 |
| Progressive ratio test 1 inactive lever presses | 2.5 | 2.6 | 3.8 | 1.6 | 1.7 | 1.6 | 1.4 | 1.9 | 1.6 | -1.6 | 1.6 | -1.6 | 1.6 | 1.5 | 1.6 | 1.7 | 1.7 | 1.6 | -1.6 | 1.5 | -1.5 | 1.9 | 1.6 |
| Total locomotion distance, NPP test | 2.5 | 3.4 | 3.7 | 1.9 | 1.9 | 1.9 | 1.9 | 1.8 | 1.9 | -1.9 | 1.9 | -1.9 | 1.9 | 1.8 | 1.9 | 1.8 | 1.6 | 1.9 | -1.9 | 1.9 | -1.9 | 1.8 | 1.7 |
| Total heroin consumption | 2.5 | 3.0 | 3.3 | -1.8 | -1.6 | -1.8 | -1.8 | -1.5 | -1.8 | 1.8 | -1.8 | 1.8 | -1.7 | -1.7 | -1.8 | -1.8 | -1.8 | -1.8 | 1.8 | -1.8 | 1.8 | -1.8 | -1.3 |
| Reaction time false alarm rate | 2.4 | 3.4 | 3.9 | 1.8 | 1.8 | 1.8 | 1.8 | 1.9 | 1.8 | -1.8 | 1.9 | -1.9 | 1.8 | 1.8 | 1.8 | 1.9 | 1.9 | 1.8 | -1.8 | 1.8 | -1.8 | 1.6 | 2.0 |
| Intermittent access day 15 total infusions | 2.4 | 2.7 | 3.1 | 1.7 | 1.5 | 1.6 | 1.5 | 1.6 | 1.7 | -1.6 | 1.7 | -1.7 | 1.8 | 1.6 | 1.6 | 1.7 | 1.7 | 1.6 | -1.6 | 1.6 | -1.6 | 1.4 | 1.7 |
| Intermittent access total infusions | 2.4 | 2.7 | 3.1 | 1.6 | 1.5 | 1.6 | 1.6 | 1.6 | 1.7 | -1.6 | 1.6 | -1.6 | 1.8 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | 1.4 | 1.7 |
| Intermittent access total locomotion | 2.4 | 2.8 | 5.3 | 1.7 | 1.7 | 1.6 | 1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | 1.8 | 1.7 | 1.6 | 1.5 | 1.5 | 1.7 | -1.7 | 1.7 | -1.7 | 1.2 | 2.3 |
| Bone: cortical porosity | 2.4 | 2.6 | 3.3 | 1.6 | 1.7 | 1.6 | 1.6 | 1.8 | 1.6 | -1.6 | 1.6 | -1.6 | 1.5 | 1.7 | 1.6 | 1.6 | 1.7 | 1.7 | -1.6 | 1.6 | -1.6 | 1.8 | 1.4 |
| Delay discounting total patch changes 6 sec | 2.3 | 3.6 | 5.4 | 1.9 | 1.9 | 1.9 | 1.8 | 1.7 | 1.9 | -1.9 | 1.8 | -1.8 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | 1.9 | -1.9 | 1.9 | -1.9 | 1.9 | 2.3 |
| Pavlov. Cond. intertrial magazine entries | 2.3 | 3.0 | 4.0 | 1.7 | 2.0 | 1.8 | 1.8 | 1.8 | 1.8 | -1.7 | 1.6 | -1.6 | 1.7 | 1.6 | 1.8 | 1.7 | 1.5 | 1.6 | -1.8 | 1.8 | -1.8 | 1.9 | 1.9 |
| Progressive ratio test 2 breakpoint | 2.3 | 2.5 | 3.7 | 1.6 | 1.5 | 1.6 | 1.5 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | 1.7 | 1.6 | 1.6 | 1.6 | 1.7 | 1.6 | -1.6 | 1.6 | -1.6 | 1.4 | 1.9 |
| Weight adjusted by age | 2.3 | 2.6 | 3.6 | -1.6 | -1.8 | -1.7 | -1.7 | -1.9 | -1.7 | 1.6 | -1.5 | 1.5 | -1.8 | -1.6 | -1.7 | -1.5 | -1.3 | -1.6 | 1.7 | -1.7 | 1.7 | -1.4 | -1.2 |
| Length with tail | 2.1 | 7.8 | 9.8 | -2.8 | -2.8 | -2.9 | -2.9 | -3.1 | -2.8 | 2.8 | -2.7 | 2.7 | -3.0 | -2.8 | -2.9 | -2.7 | -2.6 | -2.8 | 2.9 | -2.9 | 2.9 | -3.0 | -1.8 |
| Liver weight, left | 2.1 | 3.4 | 5.8 | -1.8 | -1.8 | -1.8 | -1.7 | -1.8 | -1.8 | 1.8 | -1.9 | 1.9 | -1.7 | -1.7 | -1.8 | -1.9 | -1.9 | -1.8 | 1.8 | -1.8 | 1.7 | -1.9 | -2.4 |
| Reaction time premature initiations | 2.1 | 3.0 | 4.5 | 1.7 | 1.9 | 1.8 | 1.7 | 1.5 | 1.8 | -1.7 | 1.6 | -1.6 | 1.9 | 1.6 | 1.8 | 1.6 | 1.4 | 1.7 | -1.8 | 1.8 | -1.8 | 1.4 | 2.1 |
| Locomotion distance, session 2 | 2.1 | 3.0 | 3.3 | 1.7 | 1.8 | 1.8 | 1.7 | 1.7 | 1.8 | -1.7 | 1.7 | -1.7 | 1.7 | 1.6 | 1.8 | 1.7 | 1.5 | 1.7 | -1.8 | 1.8 | -1.8 | 1.7 | 1.7 |
| Liver weight, right | 2.0 | 3.3 | 5.0 | -1.8 | -2.0 | -1.8 | -1.8 | -1.8 | -1.8 | 1.8 | -1.8 | 1.8 | -1.8 | -1.7 | -1.8 | -1.7 | -1.5 | -1.8 | 1.8 | -1.8 | 1.8 | -1.8 | -2.2 |
| Reaction time num false alarms | 1.9 | 2.6 | 3.1 | 1.6 | 1.6 | 1.6 | 1.5 | 1.8 | 1.6 | -1.6 | 1.7 | -1.7 | 1.6 | 1.5 | 1.6 | 1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.6 | 1.5 | 1.7 |
| Stereotopy head waving duration, day 7 | 1.9 | 2.3 | 3.0 | -1.5 | -1.5 | -1.5 | -1.5 | -1.5 | -1.5 | 1.6 | -1.6 | 1.6 | -1.4 | -1.6 | -1.5 | -1.6 | -1.7 | -1.6 | 1.5 | -1.5 | 1.5 | -1.5 | -1.1 |
| Latency to leave start box in cocaine runway, F | 1.9 | 2.1 | 3.1 | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.4 | 1.4 | 1.4 | 1.5 | 1.6 | 1.4 | -1.4 | 1.4 | -1.4 | 1.3 | 1.8 |
| Lifetime Intake | 1.8 | 2.0 | 2.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.6 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.3 | 1.5 |
| Delay disc. indifference point, 16s delay | 1.8 | 1.8 | 2.8 | -1.3 | -1.3 | -1.4 | -1.4 | -1.5 | -1.4 | 1.3 | -1.3 | 1.3 | -1.3 | -1.3 | -1.4 | -1.3 | -1.3 | -1.3 | 1.4 | -1.4 | 1.4 | -1.7 | -0.7 |
| Progressive ratio test 2 active lever presses | 1.7 | 1.8 | 3.1 | 1.3 | 1.3 | 1.3 | 1.3 | 1.3 | 1.3 | -1.3 | 1.3 | -1.3 | 1.4 | 1.4 | 1.3 | 1.4 | 1.5 | 1.4 | -1.3 | 1.3 | -1.3 | 1.2 | 1.8 |
| Area under the delay curve | 1.6 | 1.7 | 3.0 | -1.3 | -1.3 | -1.3 | -1.4 | -1.5 | -1.3 | 1.3 | -1.3 | 1.2 | -1.3 | -1.3 | -1.3 | -1.3 | -1.2 | -1.3 | 1.3 | -1.3 | 1.3 | -1.7 | -0.6 |
| Delay disc. indifference point, 0s delay | 1.6 | 1.7 | 2.2 | -1.3 | -1.4 | -1.3 | -1.4 | -1.4 | -1.3 | 1.3 | -1.2 | 1.2 | -1.4 | -1.3 | -1.4 | -1.3 | -1.2 | -1.3 | 1.4 | -1.4 | 1.4 | -1.5 | -0.5 |
| Conditioned reinforcement - actives | 1.5 | 1.5 | 2.3 | 1.2 | 1.3 | 1.2 | 1.2 | 1.5 | 1.2 | -1.2 | 1.1 | -1.1 | 1.3 | 1.2 | 1.2 | 1.1 | 1.0 | 1.2 | -1.2 | 1.2 | -1.2 | 1.2 | 1.3 |
| Intermittent access day 1 total infusions | 1.5 | 1.7 | 2.3 | 1.3 | 1.1 | 1.3 | 1.2 | 1.4 | 1.3 | -1.3 | 1.3 | -1.3 | 1.3 | 1.3 | 1.3 | 1.3 | 1.5 | 1.3 | -1.3 | 1.3 | -1.3 | 1.4 | 0.7 |
| Delay disc. indifference point, 24s delay | 1.5 | 1.5 | 2.2 | -1.2 | -1.3 | -1.2 | -1.2 | -1.4 | -1.2 | 1.2 | -1.2 | 1.2 | -1.3 | -1.2 | -1.3 | -1.2 | -1.1 | -1.2 | 1.2 | -1.2 | 1.3 | -1.5 | -0.8 |
| Cu content in liver | 1.5 | 1.8 | 2.0 | -1.4 | -1.3 | -1.3 | -1.3 | -1.3 | -1.3 | 1.4 | -1.4 | 1.4 | -1.3 | -1.4 | -1.3 | -1.3 | -1.4 | -1.4 | 1.3 | -1.3 | 1.3 | -1.3 | -1.1 |
| K content in liver | 1.5 | 1.5 | 1.8 | -1.3 | -1.2 | -1.2 | -1.3 | -1.4 | -1.2 | 1.2 | -1.2 | 1.2 | -1.2 | -1.3 | -1.2 | -1.2 | -1.3 | -1.3 | 1.3 | -1.3 | 1.3 | -1.3 | -0.9 |
| Indifference point 0 sec | 1.4 | 2.2 | 2.9 | 1.5 | 1.2 | 1.5 | 1.5 | 1.5 | 1.5 | -1.5 | 1.5 | -1.5 | 1.5 | 1.5 | 1.5 | 1.6 | 1.5 | 1.5 | -1.5 | 1.5 | -1.5 | 1.7 | 1.0 |
| Delay discount exponential model param | 1.4 | 1.4 | 2.7 | 1.2 | 1.2 | 1.2 | 1.2 | 1.4 | 1.2 | -1.2 | 1.1 | -1.1 | 1.2 | 1.2 | 1.2 | 1.1 | 1.1 | 1.2 | -1.2 | 1.2 | -1.2 | 1.6 | 0.6 |
| Food consumed during 24 hour testing period | 1.3 | 1.6 | 2.3 | -1.3 | -1.2 | -1.2 | -1.2 | -1.3 | -1.2 | 1.2 | -1.2 | 1.2 | -1.2 | -1.3 | -1.2 | -1.3 | -1.2 | -1.2 | 1.2 | -1.2 | 1.2 | -1.3 | -1.5 |
| Delay discounting total patch changes 0 sec | 1.3 | 2.2 | 2.6 | 1.5 | 1.2 | 1.5 | 1.5 | 1.5 | 1.5 | -1.5 | 1.5 | -1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.4 | 1.5 | -1.5 | 1.5 | -1.5 | 1.6 | 1.0 |
| Locomotion velocity, NPP test | 1.3 | 1.9 | 2.1 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.2 | 1.4 | -1.4 | 1.4 | -1.4 | 1.4 | 1.2 |
| Run reversals in cocaine runway, males | 1.3 | 1.3 | 2.8 | 1.0 | 1.3 | 1.0 | 1.0 | 1.5 | 1.0 | -1.1 | 1.1 | -1.1 | 1.0 | 1.0 | 1.0 | 1.1 | 1.3 | 1.0 | -1.0 | 1.0 | -1.0 | 1.7 | 1.0 |
| Soleus weight | 1.2 | 3.4 | 3.9 | -1.9 | -1.8 | -1.8 | -1.8 | -1.9 | -1.8 | 1.9 | -1.9 | 1.9 | -1.9 | -1.9 | -1.8 | -1.8 | -1.9 | -1.9 | 1.8 | -1.8 | 1.8 | -2.0 | -1.2 |
| Cocaine induced anxiety | 1.2 | 1.3 | 1.9 | -1.2 | -1.0 | -1.2 | -1.2 | -0.9 | -1.2 | 1.2 | -1.2 | 1.2 | -1.1 | -1.2 | -1.2 | -1.2 | -1.4 | -1.2 | 1.1 | -1.1 | 1.1 | -1.0 | -1.2 |
| Locomotion distance, session 7 | 1.2 | 1.6 | 2.0 | 1.3 | 1.2 | 1.2 | 1.2 | 1.4 | 1.2 | -1.3 | 1.3 | -1.3 | 1.2 | 1.3 | 1.2 | 1.3 | 1.2 | 1.3 | -1.2 | 1.2 | -1.2 | 1.4 | 0.9 |
| Delay discount hyperbolic model param | 1.2 | 1.3 | 2.5 | 1.1 | 1.2 | 1.1 | 1.2 | 1.3 | 1.1 | -1.1 | 1.1 | -1.1 | 1.2 | 1.2 | 1.1 | 1.1 | 1.0 | 1.1 | -1.2 | 1.2 | -1.2 | 1.6 | 0.5 |
| Vertical activity count, locomotor time 1 | 1.2 | 1.3 | 1.9 | -1.1 | -1.1 | -1.1 | -1.1 | -1.0 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -1.1 | -1.1 | -1.2 | -1.4 | -1.1 | 1.1 | -1.1 | 1.1 | -1.2 | -1.1 |
| Delay discounting total patch changes 12 sec | 1.1 | 1.5 | 2.1 | 1.2 | 1.3 | 1.2 | 1.3 | 1.1 | 1.2 | -1.2 | 1.1 | -1.1 | 1.3 | 1.2 | 1.2 | 1.1 | 1.0 | 1.2 | -1.3 | 1.3 | -1.3 | 1.4 | 1.4 |
| Pavlov. Cond. magazine entry number | 1.1 | 1.3 | 1.6 | 1.1 | 1.3 | 1.2 | 1.1 | 1.2 | 1.2 | -1.1 | 1.1 | -1.1 | 1.1 | 1.1 | 1.2 | 1.2 | 1.1 | 1.1 | -1.2 | 1.2 | -1.2 | 1.2 | 1.3 |
| Intermittent access day 1 locomotion | 1.1 | 1.2 | 1.7 | 1.1 | 1.0 | 1.0 | 1.0 | 1.3 | 1.0 | -1.1 | 1.1 | -1.1 | 1.1 | 1.1 | 1.0 | 1.1 | 1.1 | 1.1 | -1.0 | 1.0 | -1.0 | 1.1 | 0.9 |
| Baseline Anxiety | 1.1 | 1.2 | 2.5 | -1.1 | -1.2 | -1.1 | -1.0 | -1.1 | -1.1 | 1.0 | -1.1 | 1.1 | -1.1 | -1.0 | -1.0 | -1.0 | -0.9 | -1.0 | 1.1 | -1.1 | 1.1 | -1.1 | -1.6 |
| Stereotopy head waving bouts, day 7 | 1.1 | 1.2 | 1.5 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -1.1 | -1.1 | -1.2 | -1.2 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -0.9 |
| Bone: trabecular spacing | 1.1 | 1.4 | 1.8 | 1.2 | 1.1 | 1.2 | 1.2 | 1.2 | 1.2 | -1.2 | 1.1 | -1.1 | 1.1 | 1.2 | 1.2 | 1.2 | 1.2 | 1.1 | -1.2 | 1.2 | -1.2 | 1.2 | 1.4 |
| Distance traveled before self-admin | 1.1 | 1.2 | 1.5 | 1.1 | 1.0 | 1.0 | 1.1 | 1.2 | 1.1 | -1.1 | 1.0 | -1.0 | 1.2 | 1.1 | 1.0 | 1.1 | 1.2 | 1.1 | -1.1 | 1.1 | -1.1 | 1.0 | 1.0 |
| Time to tail flick, vehicle, before self-admin | 1.1 | 1.1 | 1.8 | 1.0 | 1.2 | 1.1 | 1.1 | 1.4 | 1.1 | -1.0 | 1.0 | -1.0 | 1.0 | 1.1 | 1.1 | 1.0 | 0.9 | 1.0 | -1.1 | 1.1 | -1.1 | 1.4 | 0.5 |
| Ambulatory time after self-admin | 1.1 | 1.2 | 1.8 | 1.1 | 1.2 | 1.1 | 1.3 | 1.3 | 1.1 | -1.1 | 0.9 | -0.9 | 1.3 | 1.1 | 1.2 | 0.9 | 0.6 | 1.1 | -1.2 | 1.2 | -1.2 | 0.7 | 1.3 |
| Std. dev. time between licks in bursts | 1.0 | 1.2 | 1.5 | 1.1 | 1.1 | 1.1 | 1.2 | 1.2 | 1.1 | -1.1 | 1.0 | -1.0 | 1.2 | 1.2 | 1.1 | 1.0 | 1.0 | 1.1 | -1.1 | 1.1 | -1.1 | 1.2 | 0.7 |
| Delay discounting total patch changes 24 sec | 1.0 | 1.3 | 1.8 | 1.2 | 1.1 | 1.1 | 1.2 | 1.0 | 1.1 | -1.2 | 1.1 | -1.1 | 1.1 | 1.2 | 1.1 | 1.1 | 1.0 | 1.2 | -1.2 | 1.2 | -1.2 | 1.1 | 1.4 |
| Condit. Reinf. inactive responses | 1.0 | 1.2 | 1.7 | 1.1 | 1.1 | 1.1 | 1.2 | 1.0 | 1.1 | -1.1 | 1.1 | -1.1 | 1.2 | 1.1 | 1.1 | 1.1 | 0.9 | 1.1 | -1.1 | 1.1 | -1.1 | 1.0 | 1.3 |
| Conditioned reinforcement - inactives | 1.0 | 1.2 | 2.1 | 1.0 | 1.2 | 1.1 | 1.0 | 1.2 | 1.1 | -1.1 | 1.0 | -1.0 | 1.2 | 1.0 | 1.1 | 1.1 | 1.1 | 1.0 | -1.1 | 1.1 | -1.1 | 0.9 | 1.4 |
| Intermitt. access day 15 inactive lever presses | 1.0 | 1.1 | 1.7 | 1.1 | 1.0 | 1.0 | 0.9 | 1.0 | 1.0 | -1.0 | 1.1 | -1.1 | 1.0 | 1.0 | 1.0 | 1.1 | 1.3 | 1.0 | -1.0 | 1.0 | -1.0 | 1.3 | 1.0 |
| Intermittent access day 15 total locomotion | 1.0 | 1.1 | 2.6 | 1.0 | 1.0 | 1.0 | 0.9 | 1.0 | 1.0 | -1.0 | 1.0 | -1.0 | 1.1 | 1.0 | 1.0 | 1.1 | 1.2 | 1.1 | -1.0 | 1.0 | -1.0 | 0.9 | 1.6 |
| Diff in mean of infusions in LGA sessions | 1.0 | 1.1 | 1.5 | -1.1 | -1.0 | -1.1 | -1.2 | -1.1 | -1.1 | 1.0 | -1.0 | 1.0 | -1.1 | -1.1 | -1.1 | -1.0 | -0.6 | -1.1 | 1.1 | -1.1 | 1.1 | -0.8 | -1.0 |
| Time in open arm before self-admin | 1.0 | 1.0 | 3.2 | -1.0 | -1.1 | -1.0 | -1.0 | -0.9 | -1.0 | 1.0 | -0.9 | 0.9 | -1.1 | -1.0 | -1.0 | -0.9 | -0.7 | -0.9 | 1.0 | -1.0 | 1.0 | -0.6 | -1.8 |
| Sr content in liver | 1.0 | 0.9 | 1.1 | -0.9 | -1.0 | -0.9 | -0.9 | -0.9 | -0.9 | 0.9 | -0.9 | 1.0 | -0.9 | -0.9 | -0.9 | -1.0 | -1.0 | -0.9 | 0.9 | -0.9 | 0.9 | -0.9 | -1.1 |
| Locomotor activity | 0.9 | 1.4 | 2.3 | 1.2 | 1.0 | 1.2 | 1.3 | 1.3 | 1.2 | -1.2 | 1.2 | -1.2 | 1.2 | 1.3 | 1.2 | 1.2 | 1.2 | 1.2 | -1.2 | 1.2 | -1.2 | 1.5 | 0.6 |
| Light reinforcement 2 | 0.9 | 1.2 | 1.4 | 1.2 | 1.1 | 1.1 | 1.0 | 1.1 | 1.1 | -1.1 | 1.2 | -1.2 | 1.2 | 1.1 | 1.1 | 1.1 | 1.1 | 1.2 | -1.1 | 1.1 | -1.1 | 1.1 | 1.0 |
| Social time | 0.9 | 1.2 | 2.3 | 1.1 | 0.8 | 1.1 | 1.1 | 1.1 | 1.0 | -1.1 | 1.2 | -1.2 | 1.0 | 1.2 | 1.0 | 1.2 | 1.5 | 1.2 | -1.0 | 1.0 | -1.0 | 1.3 | -0.2 |
| Intermittent access intake day 1-15 change | 0.9 | 0.9 | 1.4 | 1.0 | 0.9 | 1.0 | 0.9 | 0.9 | 1.0 | -0.9 | 1.0 | -1.0 | 1.1 | 0.8 | 1.0 | 0.9 | 0.5 | 0.9 | -1.0 | 1.0 | -1.0 | 0.6 | 1.2 |
| Novel to familiar place preference ratio | 0.9 | 1.0 | 1.4 | -0.9 | -1.1 | -1.0 | -1.0 | -0.9 | -1.0 | 0.9 | -0.9 | 0.9 | -1.0 | -0.8 | -1.0 | -0.9 | -0.6 | -0.9 | 1.0 | -1.0 | 1.0 | -0.9 | -1.2 |
| Total zone transitions, NPP test | 0.9 | 1.3 | 1.5 | 1.1 | 1.2 | 1.2 | 1.1 | 1.1 | 1.2 | -1.1 | 1.1 | -1.1 | 1.2 | 1.1 | 1.2 | 1.1 | 1.0 | 1.1 | -1.2 | 1.2 | -1.2 | 1.1 | 1.0 |
| Delay disc. indifference point, 2s delay | 0.9 | 1.0 | 1.6 | -1.0 | -1.1 | -1.0 | -1.0 | -1.1 | -1.0 | 1.0 | -0.9 | 0.9 | -1.1 | -1.0 | -1.0 | -0.9 | -0.9 | -1.0 | 1.0 | -1.0 | 1.1 | -1.3 | -0.1 |
| Parametrial fat weight | 0.8 | 1.5 | 2.1 | 1.2 | 1.2 | 1.3 | 1.4 | 1.4 | 1.3 | -1.2 | 1.2 | -1.2 | 1.3 | 1.2 | 1.3 | 1.1 | 0.5 | 1.2 | -1.4 | 1.4 | -1.4 | 1.5 | 0.4 |
| Delay discounting water rate 18 sec | 0.8 | 1.1 | 1.6 | -1.0 | -1.0 | -1.0 | -1.0 | -1.1 | -1.0 | 1.1 | -1.1 | 1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -1.3 | -1.1 | 1.0 | -1.0 | 1.0 | -1.1 | -0.8 |
| Reaction time trials AUC | 0.8 | 1.1 | 2.7 | -1.0 | -1.1 | -1.0 | -1.1 | -1.0 | -1.0 | 1.0 | -1.0 | 1.0 | -1.1 | -1.1 | -1.0 | -1.1 | -1.1 | -1.0 | 1.0 | -1.0 | 1.0 | -0.8 | -1.6 |
| Pavlov. Cond. change in total contacts | 0.8 | 1.1 | 2.0 | -1.0 | -1.1 | -1.0 | -1.0 | -1.1 | -1.0 | 1.0 | -1.0 | 1.0 | -0.8 | -0.9 | -1.0 | -1.1 | -1.2 | -0.9 | 1.0 | -1.0 | 1.0 | -1.1 | -1.4 |
| Intermittent access intake escalation 2 | 0.8 | 0.8 | 2.0 | 0.8 | 1.0 | 0.9 | 0.8 | 0.7 | 0.9 | -0.9 | 0.8 | -0.8 | 1.1 | 0.8 | 0.9 | 0.8 | 0.6 | 0.8 | -0.9 | 0.9 | -0.9 | 0.5 | 1.4 |
| Stereotopy head waving bouts, day 3 | 0.8 | 0.9 | 1.1 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | 1.0 | -1.0 | 1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | 1.0 | -1.0 | 1.0 | -1.0 | -0.8 |
| Locomotion distance, session 8 | 0.8 | 1.1 | 1.3 | 1.1 | 1.2 | 1.1 | 1.1 | 1.0 | 1.1 | -1.1 | 1.0 | -1.0 | 1.1 | 1.0 | 1.1 | 1.0 | 0.8 | 1.0 | -1.1 | 1.1 | -1.1 | 1.0 | 0.8 |
| Time in closed arm before self-admin | 0.8 | 0.9 | 1.2 | -0.9 | -1.1 | -1.0 | -1.1 | -0.8 | -1.0 | 1.0 | -0.9 | 0.9 | -1.1 | -1.0 | -1.1 | -0.9 | -0.8 | -0.9 | 1.0 | -1.1 | 1.1 | -1.1 | -0.3 |
| Time to tail flick, test, before self-admin | 0.8 | 0.8 | 1.6 | 0.9 | 0.9 | 0.8 | 0.7 | 0.6 | 0.8 | -0.9 | 1.0 | -1.0 | 0.8 | 0.9 | 0.8 | 1.0 | 1.3 | 0.9 | -0.8 | 0.8 | -0.8 | 0.9 | 1.3 |
| Time >=10cm from walls, locomotor time 1 | 0.8 | 0.8 | 1.5 | -0.8 | -0.8 | -0.8 | -0.7 | -1.1 | -0.8 | 0.9 | -0.9 | 0.9 | -0.8 | -0.9 | -0.8 | -0.9 | -1.2 | -0.9 | 0.8 | -0.8 | 0.8 | -0.9 | -1.1 |
| Epididymis fat weight | 0.7 | 1.6 | 2.3 | -1.3 | -1.2 | -1.2 | -1.2 | -1.4 | -1.3 | 1.3 | -1.3 | 1.3 | -1.2 | -1.3 | -1.2 | -1.3 | -1.5 | -1.3 | 1.2 | -1.2 | 1.2 | -1.4 | -1.1 |
| Reaction time mean | 0.7 | 1.0 | 1.5 | 1.0 | 1.0 | 1.0 | 1.2 | 0.8 | 1.0 | -1.0 | 0.9 | -0.9 | 1.2 | 1.1 | 1.0 | 0.9 | 0.9 | 1.0 | -1.0 | 1.0 | -1.0 | 1.0 | 0.4 |
| Social response proportion | 0.7 | 0.8 | 1.4 | 0.9 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | -0.9 | 0.9 | -0.9 | 0.7 | 0.9 | 0.8 | 1.0 | 1.1 | 0.9 | -0.8 | 0.8 | -0.8 | 1.2 | 0.7 |
| Cocaine response after cond. not corrected | 0.7 | 0.8 | 1.1 | 0.8 | 1.1 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 | 0.9 | -0.9 | 0.9 | 0.8 | 0.9 | 0.9 | 1.1 | 0.8 | -0.9 | 0.9 | -0.9 | 0.9 | 0.8 |
| Short access day 1 total inactive lever presses | 0.7 | 0.7 | 1.1 | 0.9 | 1.0 | 0.9 | 0.9 | 1.0 | 0.9 | -0.8 | 0.8 | -0.8 | 1.0 | 0.8 | 0.9 | 0.7 | 0.5 | 0.8 | -0.9 | 0.9 | -0.9 | 0.8 | 0.9 |
| Degree of sensitization distance | 0.7 | 0.8 | 0.9 | -0.9 | -0.9 | -0.9 | -0.9 | -0.8 | -0.9 | 0.9 | -0.8 | 0.8 | -1.0 | -0.8 | -0.9 | -0.8 | -0.7 | -0.9 | 0.9 | -0.9 | 0.9 | -0.8 | -0.8 |
| Degree of sensitization stereotypy | 0.7 | 0.7 | 1.2 | -0.9 | -0.8 | -0.9 | -0.8 | -0.8 | -0.8 | 0.9 | -0.9 | 0.9 | -0.8 | -0.9 | -0.8 | -0.9 | -1.1 | -0.9 | 0.8 | -0.8 | 0.8 | -0.8 | -0.5 |
| Condit. Reinf. active responses | 0.7 | 0.8 | 2.0 | 0.9 | 0.9 | 0.9 | 0.8 | 0.8 | 0.9 | -0.9 | 0.9 | -0.9 | 0.8 | 0.8 | 0.9 | 0.9 | 0.8 | 0.9 | -0.9 | 0.9 | -0.8 | 0.8 | 1.4 |
| Locomotion in novel chamber | 0.7 | 0.9 | 1.6 | -1.0 | -1.0 | -1.0 | -1.0 | -1.3 | -1.0 | 1.0 | -0.9 | 0.9 | -1.1 | -1.0 | -1.0 | -0.8 | -0.7 | -1.0 | 1.0 | -1.0 | 1.0 | -0.9 | 0.0 |
| Locomotion in novel chamber post-restriction | 0.7 | 0.8 | 1.6 | -0.9 | -0.8 | -0.9 | -0.8 | -1.1 | -0.8 | 0.9 | -0.9 | 0.9 | -0.8 | -0.9 | -0.9 | -0.9 | -1.3 | -0.9 | 0.9 | -0.9 | 0.9 | -1.1 | -0.0 |
| Intermittent access standard deviation | 0.6 | 0.7 | 1.0 | 0.8 | 0.6 | 0.8 | 0.7 | 0.8 | 0.8 | -0.8 | 0.9 | -0.9 | 0.9 | 0.8 | 0.8 | 0.9 | 1.0 | 0.8 | -0.8 | 0.8 | -0.8 | 0.6 | 0.6 |
| Short access day 10 total infusions | 0.6 | 0.7 | 1.3 | 0.8 | 0.7 | 0.8 | 0.7 | 0.8 | 0.8 | -0.8 | 0.9 | -0.9 | 0.9 | 0.7 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 0.5 | 1.1 |
| Compulsive drug intake | 0.6 | 0.6 | 2.1 | -0.7 | -0.8 | -0.7 | -0.7 | -0.6 | -0.7 | 0.7 | -0.7 | 0.7 | -0.8 | -0.7 | -0.7 | -0.7 | -0.8 | -0.7 | 0.7 | -0.7 | 0.7 | -0.5 | -1.5 |
| Locomotion velocity, session 1 | 0.6 | 0.6 | 2.3 | 0.8 | 0.7 | 0.8 | 0.7 | 0.6 | 0.8 | -0.8 | 0.8 | -0.9 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | 0.7 | -0.7 | 0.7 | -0.7 | 0.6 | 1.5 |
| Bone: cortical tissue density | 0.6 | 0.8 | 1.0 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | -0.9 | 0.9 | -0.9 | 1.0 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | -0.9 | 0.9 | -0.9 | 0.8 | 1.0 |
| Change in fecal boli incidents, locomotor task | 0.6 | 0.6 | 1.0 | -0.7 | -0.9 | -0.8 | -0.9 | -0.9 | -0.8 | 0.7 | -0.7 | 0.6 | -0.9 | -0.7 | -0.8 | -0.6 | -0.3 | -0.7 | 0.9 | -0.9 | 0.9 | -1.0 | 0.2 |
| Left kidney weight | 0.5 | 1.4 | 2.0 | -1.2 | -1.1 | -1.1 | -1.4 | -1.4 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | -1.3 | -1.1 | -1.1 | -1.0 | -1.2 | 1.2 | -1.2 | 1.2 | -1.3 | -1.2 |
| Mean time between licks in bursts | 0.5 | 0.7 | 0.9 | 0.9 | 0.8 | 0.8 | 0.9 | 0.9 | 0.8 | -0.8 | 0.8 | -0.8 | 0.9 | 0.9 | 0.8 | 0.8 | 0.7 | 0.9 | -0.8 | 0.8 | -0.8 | 1.0 | 0.6 |
| Reaction time number correct | 0.5 | 0.8 | 2.0 | -0.8 | -0.9 | -0.8 | -0.9 | -0.8 | -0.8 | 0.9 | -0.9 | 0.9 | -0.9 | -0.9 | -0.8 | -0.9 | -1.0 | -0.8 | 0.8 | -0.8 | 0.8 | -0.6 | -1.4 |
| Reaction time trials correct on left | 0.5 | 0.8 | 2.0 | -0.8 | -0.9 | -0.8 | -0.9 | -0.8 | -0.8 | 0.9 | -0.9 | 0.9 | -0.9 | -0.9 | -0.8 | -0.9 | -1.0 | -0.8 | 0.8 | -0.8 | 0.8 | -0.6 | -1.4 |
| Condit. Reinf. lever reinforcers received | 0.5 | 0.7 | 1.9 | 0.9 | 0.9 | 0.8 | 0.8 | 0.7 | 0.8 | -0.8 | 0.8 | -0.9 | 0.9 | 0.8 | 0.8 | 0.8 | 0.7 | 0.8 | -0.8 | 0.8 | -0.8 | 0.7 | 1.4 |
| Intermittent access intake escalation | 0.5 | 0.5 | 1.3 | 0.7 | 0.7 | 0.8 | 0.6 | 0.6 | 0.8 | -0.7 | 0.8 | -0.8 | 0.9 | 0.6 | 0.8 | 0.7 | 0.3 | 0.7 | -0.8 | 0.8 | -0.8 | 0.3 | 1.1 |
| Novelty place preference | 0.5 | 0.5 | 0.8 | -0.6 | -0.8 | -0.7 | -0.7 | -0.6 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.6 | -0.8 | -0.7 | -0.3 | -0.6 | 0.7 | -0.7 | 0.7 | -0.6 | -0.9 |
| Pavlov. Cond. intertrial magazine entries | 0.5 | 0.6 | 1.1 | 0.8 | 0.6 | 0.8 | 0.7 | 0.6 | 0.8 | -0.8 | 0.8 | -0.8 | 0.8 | 0.7 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.7 | 0.6 | 1.0 |
| Bone: cortical apparent density | 0.5 | 0.7 | 0.7 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 0.7 | 0.8 |
| Extinction: sum of active levers before priming | 0.5 | 0.6 | 0.7 | -0.8 | -0.6 | -0.8 | -0.9 | -0.6 | -0.8 | 0.8 | -0.8 | 0.8 | -0.7 | -0.7 | -0.8 | -0.7 | -0.6 | -0.8 | 0.8 | -0.8 | 0.8 | -0.8 | -0.5 |
| Delay disc. indifference point, 4s delay | 0.5 | 0.5 | 1.0 | -0.7 | -0.7 | -0.7 | -0.7 | -0.8 | -0.7 | 0.7 | -0.6 | 0.6 | -0.7 | -0.7 | -0.7 | -0.6 | -0.6 | -0.7 | 0.7 | -0.7 | 0.7 | -1.0 | -0.3 |
| Fecal boli incidents, locomotor time 1 | 0.5 | 0.6 | 0.8 | 0.7 | 0.9 | 0.8 | 0.8 | 0.6 | 0.8 | -0.8 | 0.7 | -0.7 | 0.9 | 0.7 | 0.9 | 0.6 | 0.5 | 0.7 | -0.9 | 0.9 | -0.9 | 0.7 | 0.3 |
| Reaction time trials on left | 0.4 | 0.5 | 1.6 | -0.7 | -0.7 | -0.7 | -0.7 | -0.6 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.8 | -0.8 | -0.7 | 0.6 | -0.6 | 0.6 | -0.4 | -1.3 |
| Reaction time mean AUC | 0.4 | 0.5 | 0.9 | 0.7 | 0.8 | 0.8 | 0.9 | 0.6 | 0.7 | -0.7 | 0.6 | -0.6 | 1.0 | 0.8 | 0.8 | 0.7 | 0.6 | 0.7 | -0.8 | 0.8 | -0.8 | 0.8 | 0.1 |
| Reaction time trials completed | 0.4 | 0.5 | 1.6 | -0.7 | -0.7 | -0.7 | -0.7 | -0.6 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.8 | -0.8 | -0.7 | 0.6 | -0.6 | 0.6 | -0.4 | -1.3 |
| Total sessions with >9 infusions | 0.4 | 0.4 | 0.7 | 0.7 | 0.5 | 0.6 | 0.6 | 0.8 | 0.6 | -0.6 | 0.7 | -0.7 | 0.7 | 0.7 | 0.6 | 0.7 | 0.7 | 0.7 | -0.6 | 0.6 | -0.6 | 0.5 | 0.3 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 2.4 | 0.5 | 0.8 | 0.5 | 0.6 | 0.3 | 0.6 | -0.5 | 0.5 | -0.5 | 0.7 | 0.5 | 0.5 | 0.5 | 0.4 | 0.5 | -0.6 | 0.6 | -0.6 | 0.5 | 1.6 |
| Number of responses in last shaping day | 0.4 | 0.4 | 0.9 | -0.5 | -0.7 | -0.6 | -0.8 | -0.9 | -0.6 | 0.6 | -0.4 | 0.4 | -0.6 | -0.6 | -0.7 | -0.5 | -0.4 | -0.6 | 0.7 | -0.7 | 0.7 | -0.7 | -0.1 |
| Context. condit. distance diff. score | 0.4 | 0.5 | 0.8 | -0.7 | -0.8 | -0.7 | -0.7 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.7 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -0.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.4 | 0.5 | 1.6 | -0.7 | -0.6 | -0.7 | -0.6 | -0.5 | -0.7 | 0.7 | -0.8 | 0.8 | -0.7 | -0.7 | -0.7 | -0.8 | -0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.5 | -1.3 |
| Bone: trabecular thickness | 0.4 | 0.4 | 0.6 | 0.7 | 0.6 | 0.7 | 0.6 | 0.6 | 0.7 | -0.7 | 0.7 | -0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | -0.7 | 0.7 | -0.6 | 0.6 | 0.2 |
| Active lever presses in extinction session 6 | 0.4 | 0.4 | 0.7 | -0.6 | -0.6 | -0.6 | -0.7 | -0.6 | -0.6 | 0.6 | -0.5 | 0.5 | -0.6 | -0.7 | -0.6 | -0.5 | -0.5 | -0.6 | 0.6 | -0.6 | 0.6 | -0.9 | -0.1 |
| Delta time to tail flick, test, before/after SA | 0.4 | 0.4 | 1.3 | -0.6 | -0.7 | -0.6 | -0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 0.6 | -0.7 | -0.6 | -0.6 | -0.6 | -0.5 | -0.6 | 0.6 | -0.6 | 0.6 | -0.3 | -1.1 |
| Run reversals in cocaine runway, females | 0.4 | 0.4 | 0.9 | 0.6 | 0.5 | 0.6 | 0.6 | 0.8 | 0.6 | -0.6 | 0.6 | -0.6 | 0.4 | 0.7 | 0.6 | 0.7 | 1.0 | 0.6 | -0.6 | 0.6 | -0.5 | 0.6 | 0.3 |
| Zn content in liver | 0.4 | 0.4 | 0.8 | 0.6 | 0.6 | 0.6 | 0.6 | 0.7 | 0.6 | -0.6 | 0.6 | -0.6 | 0.6 | 0.6 | 0.6 | 0.7 | 0.7 | 0.6 | -0.6 | 0.6 | -0.6 | 0.6 | 0.9 |
| Number of licking bursts | 0.3 | 0.3 | 0.8 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | -0.5 | 0.6 | -0.6 | 0.5 | 0.6 | 0.5 | 0.6 | 0.6 | 0.6 | -0.5 | 0.5 | -0.5 | 0.6 | 0.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 0.7 | -0.6 | -0.6 | -0.6 | -0.5 | -0.7 | -0.6 | 0.6 | -0.6 | 0.6 | -0.4 | -0.5 | -0.6 | -0.7 | -0.8 | -0.5 | 0.6 | -0.6 | 0.6 | -0.7 | -0.8 |
| Conditioned locomotion | 0.3 | 0.3 | 1.0 | 0.5 | 0.6 | 0.5 | 0.6 | 0.7 | 0.5 | -0.5 | 0.5 | -0.5 | 0.7 | 0.6 | 0.5 | 0.4 | 0.3 | 0.5 | -0.6 | 0.6 | -0.6 | 0.4 | 1.0 |
| Intermitt. access escalation Index | 0.3 | 0.3 | 0.7 | 0.5 | 0.4 | 0.5 | 0.7 | 0.7 | 0.6 | -0.5 | 0.4 | -0.4 | 0.5 | 0.6 | 0.6 | 0.5 | 0.4 | 0.5 | -0.6 | 0.6 | -0.6 | 0.8 | -0.3 |
| Total zone transitions, hab. session 1 | 0.3 | 0.4 | 0.8 | 0.6 | 0.7 | 0.6 | 0.7 | 0.5 | 0.6 | -0.6 | 0.6 | -0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.3 | 0.6 | -0.6 | 0.6 | -0.6 | 0.5 | 0.9 |
| Time in novel zone, NPP test | 0.3 | 0.3 | 0.6 | -0.5 | -0.7 | -0.6 | -0.5 | -0.5 | -0.6 | 0.5 | -0.5 | 0.5 | -0.6 | -0.4 | -0.6 | -0.5 | -0.2 | -0.4 | 0.6 | -0.6 | 0.6 | -0.5 | -0.8 |
| Pavlov. Cond. lever contacts | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.6 | 0.7 | 0.7 | 0.6 | -0.6 | 0.6 | -0.6 | 0.6 | 0.7 | 0.6 | 0.5 | 0.5 | 0.7 | -0.6 | 0.6 | -0.6 | 0.7 | 0.3 |
| Bone: tissue strength | 0.3 | 0.3 | 0.5 | -0.5 | -0.5 | -0.6 | -0.5 | -0.6 | -0.6 | 0.6 | -0.6 | 0.6 | -0.4 | -0.5 | -0.6 | -0.6 | -0.7 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.4 |
| Bouts of movement, locomotor time 1 | 0.3 | 0.4 | 3.4 | -0.5 | -0.5 | -0.5 | -0.6 | -0.1 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | -0.5 | -0.4 | -0.5 | -0.3 | -0.5 | 0.5 | -0.5 | 0.5 | 0.2 | -1.8 |
| Distance moved, locomotor task time 2 | 0.3 | 0.3 | 0.5 | 0.6 | 0.7 | 0.6 | 0.7 | 0.6 | 0.6 | -0.6 | 0.5 | -0.5 | 0.7 | 0.6 | 0.6 | 0.5 | 0.4 | 0.6 | -0.6 | 0.6 | -0.6 | 0.4 | 0.4 |
| Seeking ratio, delayed vs. immediate footshock | 0.3 | 0.3 | 0.5 | -0.5 | -0.6 | -0.5 | -0.7 | -0.7 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.6 | -0.5 | -0.5 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | 0.1 |
| Cd content in liver | 0.3 | 0.3 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.6 | 0.6 | -0.6 | 0.6 | -0.7 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | -0.5 | 0.5 | -0.5 | 0.5 | 0.8 |
| Se content in liver | 0.3 | 0.4 | 0.5 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 | 0.6 | -0.6 | 0.7 | -0.7 | 0.6 | 0.6 | 0.6 | 0.7 | 0.6 | 0.6 | -0.6 | 0.6 | -0.6 | 0.5 | 0.7 |
| Water consumed over 24 hours | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.4 | -0.5 | -0.5 | -0.4 | 0.5 | -0.5 | 0.5 | -0.4 | -0.5 | -0.4 | -0.5 | -0.5 | -0.5 | 0.4 | -0.4 | 0.4 | -0.5 | -0.4 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.3 | 0.9 | 0.5 | 0.5 | 0.5 | 0.3 | 0.4 | 0.5 | -0.5 | 0.6 | -0.6 | 0.4 | 0.4 | 0.4 | 0.6 | 0.6 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | 0.9 |
| Condit. Reinf. active responses | 0.2 | 0.3 | 1.2 | 0.6 | 0.6 | 0.5 | 0.5 | 0.4 | 0.5 | -0.5 | 0.6 | -0.6 | 0.6 | 0.5 | 0.5 | 0.5 | 0.4 | 0.5 | -0.5 | 0.5 | -0.5 | 0.4 | 1.1 |
| Pavlov. Cond. magazine entry latency | 0.2 | 0.3 | 0.7 | -0.5 | -0.6 | -0.5 | -0.5 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | -0.4 | -0.5 | -0.5 | -0.4 | -0.4 | 0.5 | -0.5 | 0.5 | -0.5 | -0.8 |
| Pavlov. Cond. latency score | 0.2 | 0.2 | 0.8 | -0.4 | -0.5 | -0.5 | -0.4 | -0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.3 | -0.4 | -0.5 | -0.5 | -0.6 | -0.4 | 0.5 | -0.5 | 0.5 | -0.5 | -0.9 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.6 | 0.6 | 0.6 | 0.6 | 0.7 | 0.5 | 0.6 | -0.6 | 0.6 | -0.5 | 0.8 | 0.6 | 0.6 | 0.5 | 0.1 | 0.6 | -0.6 | 0.6 | -0.6 | 0.5 | 0.1 |
| Short access day 10 total locomotion | 0.2 | 0.2 | 2.3 | 0.4 | 0.4 | 0.3 | 0.4 | 0.2 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.4 | 0.3 | 0.3 | 0.2 | 0.4 | -0.3 | 0.3 | -0.3 | -0.1 | 1.5 |
| Short access total locomotion | 0.2 | 0.2 | 0.8 | 0.4 | 0.4 | 0.4 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.4 | 0.3 | 0.4 | 0.3 | 0.4 | -0.4 | 0.4 | -0.3 | 0.2 | 0.9 |
| One hour access (0.3 mA shock) | 0.2 | 0.2 | 0.7 | 0.4 | 0.5 | 0.4 | 0.2 | 0.4 | 0.4 | -0.4 | 0.5 | -0.5 | 0.5 | 0.4 | 0.4 | 0.5 | 0.8 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.6 |
| Locomotion velocity, session 2 | 0.2 | 0.2 | 0.4 | 0.4 | 0.4 | 0.5 | 0.5 | 0.4 | 0.5 | -0.4 | 0.4 | -0.4 | 0.5 | 0.4 | 0.5 | 0.4 | 0.2 | 0.4 | -0.5 | 0.5 | -0.5 | 0.4 | 0.6 |
| Stereotopy head waving duration, day 3 | 0.2 | 0.3 | 0.4 | -0.5 | -0.6 | -0.5 | -0.5 | -0.6 | -0.5 | 0.5 | -0.5 | 0.6 | -0.5 | -0.5 | -0.5 | -0.6 | -0.6 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.3 |
| Locomotion velocity, session 8 | 0.2 | 0.3 | 0.7 | -0.5 | -0.4 | -0.5 | -0.5 | -0.5 | -0.4 | 0.5 | -0.5 | 0.5 | -0.5 | -0.6 | -0.5 | -0.5 | -0.8 | -0.6 | 0.5 | -0.5 | 0.5 | -0.5 | -0.4 |
| Condit. Reinf. lever presses | 0.2 | 0.2 | 0.4 | -0.5 | -0.4 | -0.5 | -0.4 | -0.6 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | -0.4 | -0.5 | -0.5 | -0.6 | -0.4 | 0.5 | -0.5 | 0.5 | -0.6 | -0.0 |
| Bone: cortical thickness | 0.2 | 0.3 | 1.1 | -0.5 | -0.6 | -0.5 | -0.6 | -0.4 | -0.5 | 0.5 | -0.4 | 0.4 | -0.6 | -0.5 | -0.5 | -0.4 | -0.1 | -0.4 | 0.5 | -0.5 | 0.5 | -0.4 | -1.0 |
| Breakpoint value in progressive ratio session | 0.2 | 0.2 | 0.3 | -0.5 | -0.2 | -0.4 | -0.4 | -0.3 | -0.4 | 0.5 | -0.6 | 0.6 | -0.2 | -0.4 | -0.4 | -0.5 | -0.5 | -0.5 | 0.4 | -0.4 | 0.4 | -0.4 | -0.6 |
| Delta distance traveled before/after self-admin | 0.2 | 0.2 | 0.6 | -0.5 | -0.4 | -0.4 | -0.4 | -0.4 | -0.4 | 0.5 | -0.5 | 0.6 | -0.4 | -0.5 | -0.4 | -0.6 | -0.8 | -0.5 | 0.4 | -0.4 | 0.4 | -0.5 | -0.6 |
| Time in closed arm after self-admin | 0.2 | 0.3 | 0.7 | -0.5 | -0.6 | -0.5 | -0.6 | -0.3 | -0.5 | 0.5 | -0.4 | 0.4 | -0.6 | -0.5 | -0.6 | -0.4 | -0.1 | -0.4 | 0.6 | -0.6 | 0.6 | -0.0 | -0.9 |
| Time in open arm after self-admin | 0.2 | 0.3 | 0.6 | 0.5 | 0.5 | 0.5 | 0.5 | 0.3 | 0.5 | -0.5 | 0.5 | -0.5 | 0.4 | 0.6 | 0.5 | 0.6 | 0.8 | 0.5 | -0.5 | 0.5 | -0.5 | 0.4 | 0.5 |
| Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.5 | -0.4 | -0.6 | -0.5 | -0.4 | -0.7 | -0.5 | 0.4 | -0.4 | 0.4 | -0.4 | -0.4 | -0.5 | -0.4 | -0.3 | -0.4 | 0.5 | -0.5 | 0.5 | -0.6 | -0.5 |
| Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.4 | 0.4 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | -0.4 | 0.4 | -0.4 | 0.5 | 0.5 | 0.5 | 0.4 | 0.3 | 0.4 | -0.5 | 0.5 | -0.5 | 0.6 | 0.1 |
| Rest time, locomotor task time 2 | 0.2 | 0.2 | 0.6 | -0.4 | -0.5 | -0.4 | -0.6 | -0.5 | -0.4 | 0.4 | -0.4 | 0.3 | -0.5 | -0.4 | -0.4 | -0.3 | -0.1 | -0.4 | 0.4 | -0.4 | 0.5 | -0.1 | -0.8 |
| Vertical activity count, locomotor time 2 | 0.2 | 0.2 | 0.6 | -0.5 | -0.5 | -0.5 | -0.4 | -0.2 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | -0.5 | -0.5 | -0.5 | -0.4 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.8 |
| Co content in liver | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.5 | 0.6 | 0.5 | 0.5 | -0.5 | 0.5 | -0.5 | 0.5 | 0.6 | 0.5 | 0.4 | 0.5 | 0.5 | -0.5 | 0.5 | -0.5 | 0.5 | 0.2 |
| Mn content in liver | 0.2 | 0.2 | 0.3 | -0.5 | -0.4 | -0.5 | -0.5 | -0.5 | -0.4 | 0.5 | -0.4 | 0.4 | -0.5 | -0.5 | -0.4 | -0.4 | -0.3 | -0.5 | 0.5 | -0.5 | 0.5 | -0.5 | 0.3 |
| Na content in liver | 0.2 | 0.2 | 0.3 | -0.4 | -0.3 | -0.4 | -0.5 | -0.6 | -0.4 | 0.4 | -0.4 | 0.4 | -0.5 | -0.5 | -0.4 | -0.3 | -0.5 | -0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 |
| BMI without tail | 0.1 | 0.2 | 1.6 | -0.3 | -0.7 | -0.4 | -0.4 | -0.2 | -0.4 | 0.3 | -0.2 | 0.2 | -0.4 | -0.3 | -0.4 | -0.3 | -0.1 | -0.3 | 0.4 | -0.4 | 0.4 | -0.2 | -1.3 |
| Glucose | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.3 | -0.3 | -0.3 | -0.2 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.4 |
| Times rat made contact with spout | 0.1 | 0.1 | 0.2 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.3 | 0.4 | -0.3 | 0.3 | -0.3 | -0.4 | -0.3 | -0.3 | -0.4 | -0.4 | 0.3 | -0.3 | 0.3 | -0.3 | -0.3 |
| Mean num. licks in bursts | 0.1 | 0.1 | 0.6 | -0.3 | -0.2 | -0.2 | -0.3 | -0.3 | -0.2 | 0.3 | -0.3 | 0.3 | -0.2 | -0.4 | -0.2 | -0.3 | -0.3 | -0.3 | 0.2 | -0.2 | 0.2 | -0.3 | -0.8 |
| Indifference point AUC | 0.1 | 0.1 | 1.3 | 0.3 | 0.5 | 0.3 | 0.2 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 1.1 |
| Cocaine response after cond. corrected | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | -0.2 | -0.4 | -0.2 | -0.2 | 0.3 | -0.2 | 0.2 | -0.2 | -0.4 | -0.2 | -0.2 | -0.1 | -0.3 | 0.2 | -0.2 | 0.2 | -0.3 | -0.4 |
| Saline control response | 0.1 | 0.1 | 0.2 | 0.4 | 0.5 | 0.4 | 0.4 | 0.2 | 0.4 | -0.4 | 0.4 | -0.3 | 0.5 | 0.5 | 0.4 | 0.3 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.2 | 0.2 |
| Pavlov. Cond. index score | 0.1 | 0.2 | 0.5 | -0.3 | -0.4 | -0.4 | -0.3 | -0.4 | -0.4 | 0.4 | -0.4 | 0.4 | -0.2 | -0.3 | -0.4 | -0.4 | -0.6 | -0.3 | 0.4 | -0.4 | 0.4 | -0.4 | -0.7 |
| Pavlov. Cond. response bias | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | 0.4 | 0.5 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.6 | 0.5 | 0.4 | 0.3 | 0.1 | 0.5 | -0.4 | 0.4 | -0.4 | 0.3 | 0.2 |
| Incentive Sensitization - Responses | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | -0.2 | -0.3 | -0.1 | -0.2 | 0.2 | -0.1 | 0.1 | -0.3 | -0.2 | -0.2 | -0.1 | 0.3 | -0.2 | 0.3 | -0.3 | 0.3 | 0.1 | -0.4 |
| Short access total infusions | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | 0.4 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.4 | 0.4 | 0.4 | 0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.3 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | -0.3 | 0.4 | -0.4 | 0.3 | 0.3 | 0.3 | 0.3 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.5 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.3 | -0.4 | -0.4 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.4 | -0.3 | -0.3 | -0.3 | -0.4 | 0.3 | -0.3 | 0.3 | -0.4 | -0.4 |
| Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | 0.4 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.3 | 0.4 | 0.4 | 0.4 | 0.3 | -0.4 | 0.4 | -0.4 | 0.4 | 0.1 |
| Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.2 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.2 | 0.2 | 0.3 | 0.3 | 0.2 | 0.2 | -0.3 | 0.3 | -0.3 | 0.2 | 0.3 |
| Total locomotion distance, hab. session 2 | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 | 0.4 | 0.5 | 0.4 | -0.4 | 0.5 | -0.5 | 0.4 | 0.4 | 0.4 | 0.5 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.2 |
| Pavlov. Cond. index score | 0.1 | 0.1 | 0.8 | -0.3 | -0.2 | -0.3 | -0.3 | -0.1 | -0.3 | 0.3 | -0.4 | 0.4 | -0.3 | -0.3 | -0.3 | -0.4 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.1 | -0.9 |
| Pavlov. Cond. response bias | 0.1 | 0.1 | 0.2 | 0.2 | 0.4 | 0.3 | 0.3 | 0.5 | 0.2 | -0.2 | 0.2 | -0.2 | 0.3 | 0.3 | 0.3 | 0.2 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.5 | -0.5 |
| Bone: elastic work | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 | -0.3 | 0.2 | -0.2 | 0.4 | 0.4 | 0.3 | 0.2 | 0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.2 |
| Bone: trabecular tissue density | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | 0.4 | 0.4 | 0.3 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.3 | 0.6 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 1.1 | -0.3 | -0.3 | -0.3 | -0.4 | -0.2 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.0 | -1.1 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.2 | 0.6 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.3 | 0.4 | -0.4 | 0.4 | -0.3 | -0.4 | -0.3 | -0.5 | -0.8 | -0.4 | 0.3 | -0.3 | 0.3 | -0.5 | -0.3 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.3 | 0.3 | 0.5 | 0.4 | 0.3 | 0.3 | 0.4 | -0.3 | 0.3 | -0.3 | 0.5 | 0.4 | 0.4 | 0.3 | 0.3 | 0.3 | -0.4 | 0.4 | -0.4 | 0.1 | 0.3 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.3 | -0.4 | -0.5 | -0.3 | 0.3 | -0.2 | 0.2 | -0.4 | -0.3 | -0.3 | -0.1 | 0.2 | -0.3 | 0.3 | -0.3 | 0.4 | 0.1 | -0.4 |
| Total resting periods, locomotor time 1 | 0.1 | 0.1 | 1.7 | 0.1 | 0.1 | 0.1 | -0.1 | 0.4 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.7 | -1.3 |
| Rest time, locomotor task time 1 | 0.1 | 0.2 | 0.9 | 0.2 | 0.2 | 0.2 | 0.1 | 0.6 | 0.2 | -0.3 | 0.2 | -0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.6 | 0.2 | -0.2 | 0.2 | -0.2 | 0.8 | -1.0 |
| Distance moved, locomotor task time 1 | 0.1 | 0.1 | 1.1 | 0.3 | 0.4 | 0.3 | 0.4 | -0.0 | 0.4 | -0.3 | 0.3 | -0.3 | 0.4 | 0.3 | 0.3 | 0.2 | -0.2 | 0.3 | -0.3 | 0.3 | -0.4 | -0.2 | 1.0 |
| Progressive ratio | 0.1 | 0.1 | 1.9 | -0.1 | -0.1 | -0.1 | -0.1 | -0.4 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | -0.1 | -0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.7 | 1.4 |
| Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 1.4 | -0.1 | -0.0 | -0.1 | -0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.2 | 0.0 | -0.1 | -0.1 | -0.2 | -0.3 | -0.1 | 0.1 | -0.0 | 0.0 | 0.4 | -1.2 |
| Fe content in liver | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.4 | 0.4 | 0.5 | 0.4 | -0.3 | 0.3 | -0.3 | 0.4 | 0.4 | 0.4 | 0.3 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.5 | -0.2 |
| Heart weight | 0.0 | 0.0 | 0.3 | -0.1 | 0.1 | -0.0 | -0.2 | -0.2 | -0.0 | 0.1 | 0.0 | -0.0 | 0.0 | -0.2 | -0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.2 | 0.6 |
| Tail length | 0.0 | 0.1 | 0.4 | 0.4 | 0.3 | 0.3 | 0.4 | 0.2 | 0.4 | -0.4 | 0.5 | -0.5 | 0.3 | 0.4 | 0.3 | 0.4 | 0.4 | 0.4 | -0.3 | 0.3 | -0.3 | -0.0 | 0.7 |
| Retroperitoneal fat weight | 0.0 | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | 0.2 | 0.1 | 0.3 | -0.2 | 0.2 | -0.2 | 0.3 | 0.1 | 0.3 | 0.2 | 0.0 | 0.1 | -0.3 | 0.3 | -0.3 | 0.1 | 0.3 |
| Median of all reaction times | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | -0.0 | 0.2 | -0.3 | -0.0 | 0.0 | -0.1 | 0.1 | 0.2 | 0.1 | 0.0 | -0.1 | -0.2 | 0.0 | -0.0 | 0.0 | -0.0 | -0.0 | -0.1 |
| Conditioned locomotion | 0.0 | 0.0 | 0.1 | 0.2 | -0.0 | 0.1 | 0.1 | 0.2 | 0.1 | -0.2 | 0.2 | -0.2 | 0.1 | 0.2 | 0.1 | 0.2 | 0.1 | 0.2 | -0.1 | 0.1 | -0.1 | 0.3 | 0.3 |
| Condit. Reinf. active minus inactive responses | 0.0 | 0.0 | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | -0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | 0.5 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.2 | 0.1 | 0.1 | 0.0 | -0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | 0.1 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.2 | -0.2 | 0.2 | -0.2 | 0.1 | -0.4 | -0.2 | -0.2 | -0.1 | 0.2 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.2 |
| Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.3 | -0.0 | -0.1 | -0.1 | -0.2 | 0.1 | -0.1 | 0.0 | 0.0 | -0.0 | -0.1 | 0.0 | -0.1 | 0.1 | 0.5 | -0.0 | 0.1 | -0.1 | 0.1 | 0.4 | -0.3 |
| Short access day 1 total infusions | 0.0 | 0.0 | 0.3 | -0.1 | -0.2 | -0.2 | -0.3 | 0.0 | -0.2 | 0.1 | -0.1 | 0.1 | -0.2 | -0.1 | -0.2 | -0.0 | 0.2 | -0.1 | 0.2 | -0.2 | 0.2 | 0.0 | -0.5 |
| Short access day 1 locomotion | 0.0 | 0.1 | 0.4 | 0.1 | -0.2 | -0.0 | -0.1 | 0.4 | -0.0 | -0.1 | 0.2 | -0.2 | -0.1 | 0.1 | -0.1 | 0.2 | 0.6 | 0.1 | 0.1 | -0.1 | 0.1 | 0.3 | -0.4 |
| One hour access (shock baseline) | 0.0 | 0.0 | 0.3 | 0.1 | 0.1 | 0.1 | -0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.5 | 0.1 | -0.1 | 0.0 | -0.0 | 0.2 | 0.3 |
| Locomotion velocity, session 7 | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | 0.4 | 0.2 | -0.1 | 0.2 | -0.2 | 0.1 | 0.2 | 0.1 | 0.2 | -0.1 | 0.2 | -0.1 | 0.1 | -0.1 | 0.4 | -0.1 |
| Incentive salience index mean | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | -0.1 | -0.1 | -0.2 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.2 | -0.1 | -0.1 | -0.3 | -0.1 | 0.1 | -0.1 | 0.1 | -0.2 | 0.3 |
| Time in novel zone, hab. session 1 | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.3 | -0.1 | -0.2 | -0.3 | 0.2 | -0.2 | 0.2 | -0.2 | -0.1 | -0.3 | -0.3 | -0.2 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.0 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.2 | 0.3 | 0.2 | 0.2 | 0.1 | 0.2 | -0.2 | 0.2 | -0.1 | 0.3 | 0.2 | 0.2 | 0.1 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.1 | 0.3 |
| Locomotion velocity, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.1 | 0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.2 | 0.1 | 0.1 | -0.0 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | 0.2 |
| Time in familiar zone, hab. session 2 | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 | -0.2 | -0.3 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | -0.2 | -0.1 | -0.1 | -0.1 | 0.2 | -0.2 | 0.2 | -0.3 | 0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.2 | 0.2 |
| Locomotion velocity, hab. session 2 | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.1 | 0.3 | 0.2 | -0.2 | 0.2 | -0.2 | 0.2 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | -0.2 | 0.2 | -0.2 | 0.3 | -0.1 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.2 | 0.2 | -0.1 | 0.1 | -0.2 | -0.3 | -0.2 | -0.1 | -0.1 | -0.2 | 0.2 | -0.2 | 0.2 | -0.3 | 0.3 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.4 | 0.1 | 0.2 | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | 0.0 | -0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.3 | -0.7 |
| Pavlov. Cond. change in total contacts | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 | 0.0 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | -0.0 | -0.1 |
| Pavlov. Cond. latency score | 0.0 | 0.1 | 0.6 | -0.2 | -0.1 | -0.2 | -0.1 | 0.0 | -0.2 | 0.2 | -0.2 | 0.3 | -0.2 | -0.1 | -0.2 | -0.3 | -0.2 | -0.2 | 0.2 | -0.2 | 0.2 | -0.0 | -0.8 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.0 | 0.4 | -0.0 | -0.2 | -0.1 | -0.1 | -0.3 | -0.0 | 0.0 | 0.0 | -0.0 | -0.0 | -0.1 | -0.1 | 0.0 | -0.0 | -0.0 | 0.1 | -0.1 | 0.1 | -0.3 | 0.6 |
| Distance traveled after self-admin | 0.0 | 0.0 | 0.2 | 0.1 | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | -0.1 | -0.0 | 0.0 | 0.4 | 0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.3 | 0.3 | -0.3 | -0.1 | 0.2 |
| Time to tail flick, vehicle, after self-admin | 0.0 | 0.0 | 0.2 | 0.0 | -0.2 | -0.0 | -0.1 | -0.1 | -0.1 | -0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.5 | 0.1 | 0.1 | -0.1 | 0.1 | 0.2 | -0.3 |
| Food seeking constrained by brief footshock | 0.0 | 0.1 | 0.5 | -0.2 | -0.0 | -0.1 | -0.1 | -0.3 | -0.1 | 0.2 | -0.3 | 0.3 | -0.0 | -0.2 | -0.1 | -0.3 | -0.7 | -0.2 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
| Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.7 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | -0.3 | 0.8 |
| Mg content in liver | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.2 | -0.3 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.2 | -0.2 | -0.1 | -0.1 | -0.2 | 0.2 | -0.2 | 0.2 | -0.3 | 0.1 |
| Rb content in liver | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.1 | -0.1 | 0.1 | -0.1 | -0.0 | 0.4 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.