Hub : Traits

Bone: minimum diameter

Tags: Physiology · Bone

Project: r01_doug_adams

5 loci · 22 genes with independent associations · 71 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	117463629	118343328	1	1	4.30e-08	5.57e-01	1.00e+00	Mst1
2	chr9	83390749	84777604	1	1	0.00e+00	1.65e-01	1.00e+00	Retreg2
3	chr10	54150761	55547289	1	1	4.25e-08	3.95e-04	6.37e-01	Shbg
4	chr10	89689463	93678531	46	18	9.52e-09	1.21e-08	1.00e+00	Ace Bptf C10h17orf58 Cyb561 Dcaf7 Helz Icam2 Kpna2 LOC134480889 Mrc2 Polg2 Scn4a Taco1 Tanc2 Tex2 Tlk2
5	chr10	93821746	96571013	22	1	9.16e-09	4.90e-07	3.47e-01	Gna13

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1281.99	3	1	4.5	0	1.00e+00	Cyb561 LOC134480889 Retreg2
BMI without tail	8473.79	9	1	4.5	0.99	2.61e-16	Ace C10h17orf58 Cyb561 Dcaf7 LOC134480889 Pecam1 Prr29 Retreg2 Strada
Body weight	4.38	32	5	22.7	0.34	8.50e-04	Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Ftsj3 Icam2 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Epididymis fat weight	54228.13	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Glucose	1235.87	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Heart weight	13509	1	1	4.5	0	1.00e+00	Retreg2
Left kidney weight	141259.46	1	1	4.5	0	1.00e+00	Retreg2
Right kidney weight	58428.02	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Tail length	2049.59	18	1	4.5	0.99	1.60e-36	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Ddx42 Ftsj3 Icam2 Kcnh6 Map3k3 Pecam1 Polg2 Prr29 Retreg2 Scn4a Strada Taco1 Tlk2
Length with tail	222.48	17	2	9.1	1	5.35e-39	Ace Ccdc47 Cyb561 Ddx42 Icam2 LOC120095203 Map3k3 Mst1 Pecam1 Polg2 Retreg2 Rgs9 Scn4a Strada Taco1 Tex2 Wipi1
Length without tail	64659.67	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Liver weight, left	2911.34	5	2	9.1	-0.99	5.16e-04	Icam2 Mst1 Retreg2 Scn4a Taco1
Liver weight, right	143.89	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Parametrial fat weight	615.65	1	1	4.5	0	1.00e+00	Retreg2
Retroperitoneal fat weight	5361.95	3	2	9.1	0	1.00e+00	Mst1 Retreg2 Shbg
Intraocular pressure	20040.55	2	1	4.5	0	1.00e+00	Retreg2 Shbg
Extensor digitorum longus weight	279.01	12	1	4.5	0.97	5.21e-11	Ace C10h17orf58 Ccdc47 Cyb561 Icam2 Kcnh6 Map3k3 Retreg2 Scn4a Taco1 Tex2 Tlk2
Soleus weight	115.65	1	1	4.5	0	1.00e+00	Retreg2
Tibialis anterior weight	4881.94	1	1	4.5	0	1.00e+00	Retreg2
Tibia length	1639.71	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Number of licking bursts	157119.65	1	1	4.5	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	53101.62	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Times rat made contact with spout	305.36	1	1	4.5	0	1.00e+00	Retreg2
Mean time between licks in bursts	199507.71	1	1	4.5	0	1.00e+00	Retreg2
Mean num. licks in bursts	142600.29	1	1	4.5	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	94042.02	1	1	4.5	0	1.00e+00	Retreg2
Water consumed over 24 hours	103408.69	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	57504.43	2	1	4.5	0	1.00e+00	LOC102550334 Retreg2
Patch foraging indifference point AUC	66581.81	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Indifference point function ln k	71040.92	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Indifference point function log k	71040.92	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 0 sec	120264.14	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging total patch changes 12 sec	3635.63	3	2	9.1	0	1.00e+00	Mst1 Pecam1 Retreg2
Patch foraging total patch changes 18 sec	58889.67	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 24 sec	83554.6	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 6 sec	6534.25	4	1	4.5	1	9.04e-06	LOC102550334 LOC120095200 Retreg2 Rgs9
Patch foraging time to switch 0 sec	156618.53	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	148807.58	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	161858.08	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	103280.07	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 24 sec	2351.36	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	3954.86	1	1	4.5	0	1.00e+00	Retreg2
Locomotor activity	15.72	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Locomotor testing distance	44732.22	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotor testing rearing	76214.5	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Light reinforcement 1	155242.72	1	1	4.5	0	1.00e+00	Retreg2
Light reinforcement 2	53965.57	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Reaction time number correct	153465.22	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean minus median	205810.62	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean minus median AUC	104201.52	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms	28542.61	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	53251.53	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	153465.22	1	1	4.5	0	1.00e+00	Retreg2
Reaction time trials on left	149991.58	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean	94380.53	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean AUC	113341.21	1	1	4.5	0	1.00e+00	Retreg2
Median of all reaction times	31417.12	1	1	4.5	0	1.00e+00	Retreg2
Reaction time omissions	34267.91	1	1	4.5	0	1.00e+00	Retreg2
Reaction time false alarm rate	451.08	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time premature initiation rate	36877.02	1	1	4.5	0	1.00e+00	Retreg2
Reaction time premature initiations	138718.63	1	1	4.5	0	1.00e+00	Retreg2
Std. dev. reaction times	74746.42	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time trials completed	149991.58	1	1	4.5	0	1.00e+00	Retreg2
Reaction time trials AUC	151696.42	1	1	4.5	0	1.00e+00	Retreg2
Social response proportion	17657.99	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Social responses	2847.52	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Social time	44238.34	1	1	4.5	0	1.00e+00	Retreg2
Conditioned locomotion	6074.35	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	65812.39	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	64247.35	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response before conditioning	2800.41	1	1	4.5	0	1.00e+00	Retreg2
Saline control response	6522.43	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	3346.62	12	1	4.5	-0.99	6.82e-13	Ace C10h17orf58 Ccdc47 Cyb561 Icam2 Kcnh6 Mst1 Prr29 Retreg2 Scn4a Taco1 Tex2
Condit. Reinf. active-inactive response ratio	91582.24	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	355.78	18	2	9.1	-0.96	4.73e-16	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Gna13 Icam2 Kcnh6 LOC102550334 Mst1 Pecam1 Prr29 Retreg2 Scn4a Strada Taco1 Tex2 Wipi1
Condit. Reinf. inactive responses	21067.54	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	7960.29	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever reinforcers received	190.87	11	1	4.5	-0.95	5.96e-06	Ace Bptf C10h17orf58 Gna13 Icam2 Kcnh6 Mst1 Prr29 Retreg2 Scn4a Wipi1
Pavlov. Cond. lever latency	5465.68	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	24773.4	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	114781.94	1	1	4.5	0	1.00e+00	Retreg2
Pavlov. Cond. index score	24017.04	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	29259.45	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	11053	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	8453.95	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	1337.48	26	2	9.1	-0.95	3.23e-40	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Ftsj3 Icam2 Kcnh6 Kpna2 LOC108352141 LOC134480889 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2
Pavlov. Cond. lever-magazine prob. diff.	22461.1	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	2629.8	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	191492.54	1	1	4.5	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	77543.68	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	41346.85	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access intake day 1-15 change	105304.97	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation	104773.43	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation 2	107995.31	1	1	4.5	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	118279.42	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Intermitt. access day 15 inactive lever presses	208241.66	1	1	4.5	0	1.00e+00	Retreg2
Intermitt. access escalation Index	92516.01	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Intermittent access day 1 total infusions	77765.1	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	131485.34	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	83205.14	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access total infusions	675.9	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access day 1 locomotion	104459.41	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	177836.92	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access total locomotion	45.91	13	1	4.5	0.91	7.28e-09	Bptf C10h17orf58 Ccdc47 Ddx42 Icam2 Map3k3 Pecam1 Prr29 Retreg2 Scn4a Strada Taco1 Tex2
Intermittent access standard deviation	100956.84	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Cocaine induced anxiety	160280.46	1	1	4.5	0	1.00e+00	Retreg2
Post-drug Anxiety	20460.83	1	1	4.5	0	1.00e+00	Retreg2
Baseline Anxiety	103471.3	1	1	4.5	0	1.00e+00	Retreg2
Lifetime Intake	6830.03	1	1	4.5	0	1.00e+00	Retreg2
Incentive Sensitization - Responses	163579.25	1	1	4.5	0	1.00e+00	Retreg2
Incentive Sensitization - Breakpoint	142790.8	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 active lever presses	99872.69	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	96247.61	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	75556.75	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Progressive ratio test 2 active lever presses	57222.6	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 2 breakpoint	34975.96	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	164104.71	1	1	4.5	0	1.00e+00	Retreg2
Total sessions with >9 infusions	3995.08	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 1 total inactive lever presses	57219.08	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 10 total inactive lever presses	108578.43	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 1 total infusions	111479.43	1	1	4.5	0	1.00e+00	Retreg2
Short access day 10 total infusions	38157.63	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access total infusions	33946.03	1	1	4.5	0	1.00e+00	Retreg2
Short access day 1 locomotion	84055.65	1	1	4.5	0	1.00e+00	Retreg2
Short access day 10 total locomotion	45402.16	4	1	4.5	1	1.07e-03	C10h17orf58 Mst1 Prr29 Retreg2
Short access total locomotion	34144.06	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Compulsive drug intake	65439.45	1	1	4.5	0	1.00e+00	Retreg2
One hour access (0.3 mA shock)	9669.44	1	1	4.5	0	1.00e+00	Retreg2
One hour access (shock baseline)	140263.4	1	1	4.5	0	1.00e+00	Retreg2
Number of responses in last shaping day	51289.19	1	1	4.5	0	1.00e+00	Retreg2
Context. condit. distance diff. score	970.59	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, session 1	14615.25	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 1	4416.18	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, session 2	4702.2	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	2393.66	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, session 3	2332.53	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	4.5	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	2943.11	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	6074.03	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	708.6	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	1934.91	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving bouts, day 7	10466.92	1	1	4.5	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	8847.36	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, session 8	1892.98	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 8	673.32	1	1	4.5	0	1.00e+00	Retreg2
Degree of sensitization distance	7696.03	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	8496.38	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	4120.78	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	1097.66	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	11664.93	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	9693.11	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Incentive salience index mean	7398.25	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	10735.09	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	41873.03	1	1	4.5	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	17770.84	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	920.97	2	2	9.1	0	1.00e+00	Retreg2 Shbg
Total locomotion distance, hab. session 1	850.74	2	1	4.5	0	1.00e+00	Retreg2 Shbg
Locomotion velocity, hab. session 1	571.87	2	1	4.5	0	1.00e+00	Retreg2 Shbg
Time in familiar zone, hab. session 2	11707.23	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	12499.19	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	101.7	3	1	4.5	0	1.00e+00	Mst1 Retreg2 Shbg
Total locomotion distance, hab. session 2	96.8	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	145.53	1	1	4.5	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	27762.34	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Novelty place preference	27201.76	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	20429.72	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	4124.77	2	2	9.1	0	1.00e+00	Retreg2 Shbg
Total locomotion distance, NPP test	3563.56	2	1	4.5	0	1.00e+00	Retreg2 Shbg
Locomotion velocity, NPP test	2026.67	2	1	4.5	0	1.00e+00	Retreg2 Shbg
Pavlov. Cond. lever latency	1120.34	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	4539.35	1	1	4.5	0	1.00e+00	Retreg2
Pavlov. Cond. index score	899.58	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	935.96	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	1539.83	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2162.19	1	1	4.5	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	277.69	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	979.4	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	530.67	4	1	4.5	-0.98	4.12e-03	Mst1 Retreg2 Taco1 Tlk2
Bone: apparent density	22268.03	1	1	4.5	0	1.00e+00	Retreg2
Bone surface	520.07	20	2	9.1	1	1.64e-52	Abca5 Abca6 Ace Arsg Ccdc47 Cyb561 Ddx42 Fam20a Ftsj3 Icam2 Kcnh6 LOC134480889 Mst1 Retreg2 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2
Bone volume	1996.85	12	1	4.5	1	1.16e-19	Abca5 Abca6 Arsg Ccdc47 Cyb561 Fam20a Ftsj3 Icam2 Mst1 Retreg2 Taco1 Tlk2
Bone: connectivity density	7098.55	1	1	4.5	0	1.00e+00	Retreg2
Bone: cortical apparent density	11322.9	4	1	4.5	-1	4.57e-04	Abca5 Abca6 LOC134480889 Retreg2
Bone: cortical area	9496.01	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: cortical porosity	73.7	16	1	4.5	-0.81	2.14e-08	Ace Ccdc47 Cyb561 Dcaf7 Ftsj3 Icam2 Kcnh6 LOC108352141 LOC134480889 Mrc2 Prr29 Retreg2 Scn4a Taco1 Tanc2 Tlk2
Bone: cortical porosity	214.82	11	1	4.5	0.99	1.19e-21	Cyb561 Dcaf7 Icam2 LOC108352141 LOC134480889 Mrc2 Prr29 Retreg2 Scn4a Taco1 Tlk2
Bone: cortical thickness	128.4	9	2	9.1	-0.96	3.38e-08	Abca5 Abca6 Arsg Fam20a Helz Icam2 Map2k6 Mst1 Retreg2
Bone: cortical thickness	6116.53	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: cortical tissue density	24230.99	2	1	4.5	0	1.00e+00	Abca5 Retreg2
Bone: elastic displacement	29626.25	1	1	4.5	0	1.00e+00	Retreg2
Bone: elastic work	757.88	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	304.02	38	35	159.1	1	6.45e-125	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: endosteal perimeter	382.7	38	37	168.2	0.99	1.87e-117	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: final force	3544.85	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: final moment	548.75	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	315.75	39	35	159.1	0.99	1.78e-120	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: maximum diameter	526.73	25	2	9.1	1	9.63e-50	Abca5 Abca6 Ace Arsg Bptf Ccdc47 Cyb561 Dcaf7 Fam20a Ftsj3 Gna13 Helz Icam2 Kpna2 LOC120095203 LOC134480889 Mst1 Retreg2 Scn4a Shbg Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: maximum force	17305.93	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	12386.14	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	320.94	39	16	72.7	0.99	2.29e-106	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: periosteal perimeter	591.87	28	2	9.1	0.99	9.38e-65	Abca5 Abca6 Ace Arsg C10h17orf58 Ccdc47 Cyb561 Dcaf7 Fam20a Gna13 Icam2 Kcnh6 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Mst1 Retreg2 Rgs9 Scn4a Shbg Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: post-yield work	25428.45	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	17808.98	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	12264.67	1	1	4.5	0	1.00e+00	Retreg2
Bone: trabecular number	41138.39	1	1	4.5	0	1.00e+00	Retreg2
Bone: trabecular spacing	15656.57	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: trabecular thickness	16647.3	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	26817.91	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Breakpoint value in progressive ratio session	56217.72	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	134013.73	1	1	4.5	0	1.00e+00	Retreg2
Distance traveled after self-admin	100820.36	1	1	4.5	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	1271.86	1	1	4.5	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	54811.83	1	1	4.5	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	54252.87	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Extinction: sum of active levers before priming	45807.86	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Active lever presses in extinction session 6	1571.88	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Delta distance traveled before/after self-admin	12434.77	1	1	4.5	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	96034.01	1	1	4.5	0	1.00e+00	Retreg2
Time in closed arm before self-admin	44133.6	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in closed arm after self-admin	9759.54	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in open arm before self-admin	34587.99	1	1	4.5	0	1.00e+00	Retreg2
Time in open arm after self-admin	979.73	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Sum of active levers in priming session hrs 5-6	3877.89	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	25677.46	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Time to tail flick, vehicle, after self-admin	118286.85	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	32803.11	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, test, after self-admin	5828.87	1	1	4.5	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	18281.67	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Delta time to tail flick, test, before/after SA	56832.34	1	1	4.5	0	1.00e+00	Retreg2
Ambulatory time before self-admin	171079.71	1	1	4.5	0	1.00e+00	Retreg2
Ambulatory time after self-admin	88230.17	1	1	4.5	0	1.00e+00	Retreg2
Total heroin consumption	961.5	1	1	4.5	0	1.00e+00	Retreg2
Area under the delay curve	81605.23	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	9477.47	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	74803.61	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	825.84	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	99983.64	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 4s delay	2525.7	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	101423.99	1	1	4.5	0	1.00e+00	Retreg2
Delay discount exponential model param	60214.95	1	1	4.5	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	45715.54	1	1	4.5	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	150160.89	1	1	4.5	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	23481.3	1	1	4.5	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	49255.61	1	1	4.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	41590.88	1	1	4.5	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	11802.64	1	1	4.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	75951.88	1	1	4.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	159283.67	1	1	4.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	219061.96	1	1	4.5	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	161986.9	1	1	4.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	174298.32	1	1	4.5	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	190079.87	1	1	4.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	83778.18	1	1	4.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	34268.85	1	1	4.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	138414.05	1	1	4.5	0	1.00e+00	Retreg2
Weight adjusted by age	161973.18	1	1	4.5	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	49395.56	1	1	4.5	0	1.00e+00	Retreg2
Locomotion in novel chamber	16301.47	1	1	4.5	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	154642.04	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio	157894.89	1	1	4.5	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	7338.76	1	1	4.5	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	118281.2	1	1	4.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	37174.37	1	1	4.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	29861.56	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	58575.8	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	28379.24	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	7140.1	1	1	4.5	0	1.00e+00	Retreg2
Cd content in liver	12.23	1	0	0	0	1.00e+00	Shbg
Co content in liver	4721.74	1	1	4.5	0	1.00e+00	Retreg2
Cu content in liver	162.43	1	1	4.5	0	1.00e+00	Retreg2
Fe content in liver	5656.2	1	1	4.5	0	1.00e+00	Retreg2
K content in liver	6593.53	1	1	4.5	0	1.00e+00	Retreg2
Mg content in liver	24493.99	1	1	4.5	0	1.00e+00	Retreg2
Mn content in liver	4374.36	1	1	4.5	0	1.00e+00	Retreg2
Na content in liver	16641.94	1	1	4.5	0	1.00e+00	Retreg2
Rb content in liver	428.45	1	1	4.5	0	1.00e+00	Retreg2
Zn content in liver	15755.62	1	1	4.5	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.7
Adipose	alternative TSS	2	0.1	1.84
Adipose	gene expression	5	0.1	1.81
Adipose	isoform ratio	0	0	1.71
Adipose	intron excision ratio	0	0	2.09
Adipose	mRNA stability	1	0	1.76
BLA	alternative polyA	2	0.1	1.86
BLA	alternative TSS	0	0	1.78
BLA	gene expression	6	0.1	1.9
BLA	isoform ratio	0	0	1.77
BLA	intron excision ratio	1	0	1.82
BLA	mRNA stability	2	0.1	1.84
Brain	alternative polyA	0	0	1.74
Brain	alternative TSS	0	0	1.77
Brain	gene expression	5	0	1.82
Brain	isoform ratio	2	0	1.72
Brain	intron excision ratio	0	0	1.85
Brain	mRNA stability	2	0	1.76
Eye	alternative polyA	0	0	1.92
Eye	alternative TSS	0	0	2.03
Eye	gene expression	0	0	1.85
Eye	isoform ratio	0	0	1.99
Eye	intron excision ratio	0	0	1.79
Eye	mRNA stability	0	0	1.85
IC	alternative polyA	1	0.1	1.94
IC	alternative TSS	1	0.1	1.78
IC	gene expression	7	0.1	1.9
IC	isoform ratio	0	0	1.85
IC	intron excision ratio	0	0	1.89
IC	mRNA stability	1	0.1	1.87
IL	alternative polyA	0	0	1.84
IL	alternative TSS	1	0.1	1.66
IL	gene expression	4	0.1	1.86
IL	isoform ratio	1	0.1	1.8
IL	intron excision ratio	0	0	1.71
IL	mRNA stability	2	0.1	1.81
LHb	alternative polyA	0	0	1.73
LHb	alternative TSS	2	0.3	1.62
LHb	gene expression	2	0.1	1.82
LHb	isoform ratio	0	0	1.74
LHb	intron excision ratio	0	0	1.64
LHb	mRNA stability	1	0.1	1.79
Liver	alternative polyA	3	0.1	1.96
Liver	alternative TSS	4	0.1	1.88
Liver	gene expression	5	0.1	1.85
Liver	isoform ratio	3	0.1	1.86
Liver	intron excision ratio	2	0	1.93
Liver	mRNA stability	5	0.2	1.81
NAcc	alternative polyA	1	0	11.01
NAcc	alternative TSS	1	0	1.79
NAcc	gene expression	9	0.1	1.82
NAcc	isoform ratio	1	0	1.73
NAcc	intron excision ratio	1	0	1.77
NAcc	mRNA stability	1	0	1.87
OFC	alternative polyA	0	0	2.04
OFC	alternative TSS	2	0.3	1.82
OFC	gene expression	3	0.1	1.86
OFC	isoform ratio	0	0	1.73
OFC	intron excision ratio	0	0	1.6
OFC	mRNA stability	0	0	1.8
PL	alternative polyA	4	0.1	1.81
PL	alternative TSS	6	0.2	1.83
PL	gene expression	7	0.1	1.85
PL	isoform ratio	2	0	1.79
PL	intron excision ratio	1	0	1.77
PL	mRNA stability	0	0	1.84
pVTA	alternative polyA	0	0	1.82
pVTA	alternative TSS	0	0	1.82
pVTA	gene expression	7	0.1	1.89
pVTA	isoform ratio	0	0	1.77
pVTA	intron excision ratio	1	0	1.8
pVTA	mRNA stability	2	0.1	1.79
RMTg	alternative polyA	0	0	1.5
RMTg	alternative TSS	0	0	1.75
RMTg	gene expression	1	0	1.76
RMTg	isoform ratio	0	0	1.66
RMTg	intron excision ratio	0	0	1.92
RMTg	mRNA stability	0	0	1.77