Hub : Traits

Bone: minimum diameter

Tags: Physiology · Bone

Project: r01_doug_adams

5 loci · 17 genes with independent associations · 70 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	117463629	118343328	1	1	2.63e-10	5.57e-01	1.00e+00	Mst1
2	chr9	83390749	84777604	1	1	0.00e+00	1.65e-01	1.00e+00	Retreg2
3	chr10	54150761	55547289	1	1	4.50e-08	3.95e-04	6.76e-01	Shbg
4	chr10	89689463	93678531	46	13	9.52e-09	1.21e-08	1.00e+00	Ace Bptf C10h17orf58 Cyb561 Dcaf7 Helz Icam2 Kpna2 LOC134480889 Scn4a Taco1 Tlk2
5	chr10	93821746	96571013	21	1	9.16e-09	4.90e-07	3.47e-01	Gna13

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	291.4	3	1	5.9	0	1.00e+00	Cyb561 LOC134480889 Retreg2
BMI without tail	3371.9	9	1	5.9	0.98	8.62e-12	Ace C10h17orf58 Cyb561 Dcaf7 LOC134480889 Pecam1 Prr29 Retreg2 Strada
Body weight	4.38	32	5	29.4	0.59	6.01e-10	Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Ftsj3 Icam2 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Epididymis fat weight	18149.94	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Glucose	336.01	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Heart weight	3065.65	1	1	5.9	0	1.00e+00	Retreg2
Left kidney weight	55046.11	1	1	5.9	0	1.00e+00	Retreg2
Right kidney weight	20208.48	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Tail length	646.14	18	1	5.9	0.96	1.73e-24	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Ddx42 Ftsj3 Icam2 Kcnh6 Map3k3 Pecam1 Polg2 Prr29 Retreg2 Scn4a Strada Taco1 Tlk2
Length with tail	56.4	17	2	11.8	1	1.78e-30	Ace Ccdc47 Cyb561 Ddx42 Icam2 LOC120095203 Map3k3 Mst1 Pecam1 Polg2 Retreg2 Rgs9 Scn4a Strada Taco1 Tex2 Wipi1
Length without tail	23623.74	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Liver weight, left	707.06	5	2	11.8	-0.96	8.50e-03	Icam2 Mst1 Retreg2 Scn4a Taco1
Liver weight, right	44.57	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Parametrial fat weight	181.56	1	1	5.9	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1325.72	3	2	11.8	0	1.00e+00	Mst1 Retreg2 Shbg
Intraocular pressure	5198.27	2	1	5.9	0	1.00e+00	Retreg2 Shbg
Extensor digitorum longus weight	67.07	12	1	5.9	0.89	1.80e-06	Ace C10h17orf58 Ccdc47 Cyb561 Icam2 Kcnh6 Map3k3 Mst1 Retreg2 Scn4a Taco1 Tlk2
Soleus weight	20.71	1	1	5.9	0	1.00e+00	Retreg2
Tibialis anterior weight	1158.38	1	1	5.9	0	1.00e+00	Retreg2
Tibia length	396.37	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Number of licking bursts	67424.86	1	1	5.9	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	17761.06	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Times rat made contact with spout	71.66	1	1	5.9	0	1.00e+00	Retreg2
Mean time between licks in bursts	111630.35	1	1	5.9	0	1.00e+00	Retreg2
Mean num. licks in bursts	56750.08	1	1	5.9	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	34168.6	1	1	5.9	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	13063.24	3	1	5.9	0	1.00e+00	LOC102550334 Mst1 Retreg2
Patch foraging indifference point AUC	25114.54	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Indifference point function ln k	27906.36	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Indifference point function log k	27906.36	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	791.93	3	2	11.8	0	1.00e+00	Mst1 Pecam1 Retreg2
Patch foraging total patch changes 18 sec	20236.6	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 24 sec	37424.62	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 6 sec	1953.41	4	1	5.9	1	1.48e-03	LOC102550334 LOC120095200 Retreg2 Rgs9
Patch foraging time to switch 0 sec	66489.31	1	1	5.9	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	60426.37	1	1	5.9	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	70639.93	1	1	5.9	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	33728.57	1	1	5.9	0	1.00e+00	Retreg2
Patch foraging water rate 24 sec	523.92	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	837.86	1	1	5.9	0	1.00e+00	Retreg2
Locomotor activity	26.79	1	1	5.9	0	1.00e+00	Mst1
Locomotor testing distance	13845.45	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Locomotor testing rearing	31715.18	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Light reinforcement 1	66311.75	1	1	5.9	0	1.00e+00	Retreg2
Light reinforcement 2	18398.05	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Reaction time number correct	63471.78	1	1	5.9	0	1.00e+00	Retreg2
Reaction time mean minus median	119950.29	1	1	5.9	0	1.00e+00	Retreg2
Reaction time mean minus median AUC	62004.19	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms	7685.9	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	17513.8	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	63471.78	1	1	5.9	0	1.00e+00	Retreg2
Reaction time trials on left	60883.54	1	1	5.9	0	1.00e+00	Retreg2
Reaction time mean	29724.21	1	1	5.9	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	5.9	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	5.9	0	1.00e+00	Retreg2
Reaction time omissions	8364.84	1	1	5.9	0	1.00e+00	Retreg2
Reaction time false alarm rate	111.7	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Reaction time premature initiation rate	9733.76	1	1	5.9	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	5.9	0	1.00e+00	Retreg2
Std. dev. reaction times	30437.76	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Reaction time trials completed	60883.54	1	1	5.9	0	1.00e+00	Retreg2
Reaction time trials AUC	62130.65	1	1	5.9	0	1.00e+00	Retreg2
Social response proportion	4397.95	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Social responses	640.25	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Social time	11650.06	1	1	5.9	0	1.00e+00	Retreg2
Conditioned locomotion	1400.08	1	1	5.9	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	5.9	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	5.9	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	5.9	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	917.89	12	2	11.8	-0.94	4.60e-08	Ace C10h17orf58 Ccdc47 Cyb561 Icam2 Kcnh6 Mst1 Prr29 Retreg2 Scn4a Taco1 Tex2
Condit. Reinf. active-inactive response ratio	28713.86	1	1	5.9	0	1.00e+00	Retreg2
Condit. Reinf. active responses	92.39	18	2	11.8	-0.8	2.63e-07	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Gna13 Icam2 Kcnh6 LOC102550334 Mst1 Pecam1 Prr29 Retreg2 Scn4a Strada Taco1 Tex2 Wipi1
Condit. Reinf. inactive responses	5466.41	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1963.38	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever reinforcers received	52.11	11	1	5.9	-0.82	1.88e-03	Ace Bptf C10h17orf58 Gna13 Icam2 Kcnh6 Mst1 Prr29 Retreg2 Scn4a Wipi1
Pavlov. Cond. lever latency	1278.33	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	39811.91	1	1	5.9	0	1.00e+00	Retreg2
Pavlov. Cond. index score	6407.33	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	451	26	2	11.8	-0.8	1.28e-18	Ace Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Ftsj3 Icam2 Kcnh6 Kpna2 LOC108352141 LOC134480889 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	100795.1	1	1	5.9	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	32505.31	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	5172.85	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Intermittent access intake day 1-15 change	63945.95	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation	63041.23	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation 2	36175.43	1	1	5.9	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	90342.67	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Intermitt. access day 15 inactive lever presses	123608.2	1	1	5.9	0	1.00e+00	Retreg2
Intermitt. access escalation Index	46701.01	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Intermittent access day 1 total infusions	33063.01	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	48731.91	1	1	5.9	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	5.9	0	1.00e+00	Retreg2
Intermittent access total infusions	181.04	1	1	5.9	0	1.00e+00	Retreg2
Intermittent access day 1 locomotion	34964.22	1	1	5.9	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	85548.8	1	1	5.9	0	1.00e+00	Retreg2
Intermittent access total locomotion	17.28	14	1	5.9	0.77	2.47e-05	Bptf C10h17orf58 Ccdc47 Ddx42 Icam2 Kpna2 Map3k3 Pecam1 Prr29 Retreg2 Scn4a Strada Taco1 Tex2
Intermittent access standard deviation	56995.61	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Cocaine induced anxiety	69097.7	1	1	5.9	0	1.00e+00	Retreg2
Post-drug Anxiety	4753.56	1	1	5.9	0	1.00e+00	Retreg2
Baseline Anxiety	33506.24	1	1	5.9	0	1.00e+00	Retreg2
Lifetime Intake	1655.49	1	1	5.9	0	1.00e+00	Retreg2
Incentive Sensitization - Responses	71347.91	1	1	5.9	0	1.00e+00	Retreg2
Incentive Sensitization - Breakpoint	55273.76	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio test 1 active lever presses	31979.35	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	30292.17	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	31120.43	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Progressive ratio test 2 active lever presses	15263.76	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio test 2 breakpoint	8542.35	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	72504.33	1	1	5.9	0	1.00e+00	Retreg2
Total sessions with >9 infusions	1005.82	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Short access day 1 total inactive lever presses	19749.92	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Short access day 10 total inactive lever presses	69453.48	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Short access day 1 total infusions	19198	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Short access day 10 total infusions	11366.61	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Short access total infusions	8778.92	1	1	5.9	0	1.00e+00	Retreg2
Short access day 1 locomotion	24803.24	1	1	5.9	0	1.00e+00	Retreg2
Short access day 10 total locomotion	22050.66	4	1	5.9	1	4.97e-03	C10h17orf58 Mst1 Prr29 Retreg2
Short access total locomotion	9355.68	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Compulsive drug intake	9345.9	2	1	5.9	0	1.00e+00	Mst1 Retreg2
One hour access (0.3 mA shock)	2329.1	1	1	5.9	0	1.00e+00	Retreg2
One hour access (shock baseline)	54988.81	1	1	5.9	0	1.00e+00	Retreg2
Number of responses in last shaping day	13618.48	1	1	5.9	0	1.00e+00	Retreg2
Context. condit. distance diff. score	212.47	1	1	5.9	0	1.00e+00	Retreg2
Locomotion velocity, session 1	3523.61	1	1	5.9	0	1.00e+00	Retreg2
Locomotion distance, session 1	1024.77	1	1	5.9	0	1.00e+00	Retreg2
Locomotion velocity, session 2	1110.36	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	508.11	1	1	5.9	0	1.00e+00	Retreg2
Locomotion velocity, session 3	507.49	1	1	5.9	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	5.9	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	507.07	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving bouts, day 7	2509.72	1	1	5.9	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	2115.93	1	1	5.9	0	1.00e+00	Retreg2
Locomotion velocity, session 8	409.23	1	1	5.9	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	5.9	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	1027.5	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	5.9	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	5.9	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	5.9	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	2347.96	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Incentive salience index mean	1780.77	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	226.54	2	2	11.8	0	1.00e+00	Retreg2 Shbg
Total locomotion distance, hab. session 1	204.18	2	1	5.9	0	1.00e+00	Retreg2 Shbg
Locomotion velocity, hab. session 1	139.72	2	1	5.9	0	1.00e+00	Retreg2 Shbg
Time in familiar zone, hab. session 2	2966.16	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	30.27	3	1	5.9	0	1.00e+00	Mst1 Retreg2 Shbg
Total locomotion distance, hab. session 2	22.17	1	1	5.9	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	5.9	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7678.6	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	977.72	2	2	11.8	0	1.00e+00	Retreg2 Shbg
Total locomotion distance, NPP test	850.24	2	1	5.9	0	1.00e+00	Retreg2 Shbg
Locomotion velocity, NPP test	482.58	2	1	5.9	0	1.00e+00	Retreg2 Shbg
Pavlov. Cond. lever latency	276.98	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	5.9	0	1.00e+00	Retreg2
Pavlov. Cond. index score	214.07	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	372.95	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	82.71	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	127.76	4	2	11.8	-0.91	3.10e-02	Mst1 Retreg2 Taco1 Tlk2
Bone: apparent density	5461.77	1	1	5.9	0	1.00e+00	Retreg2
Bone surface	134.46	20	2	11.8	0.99	1.90e-38	Abca5 Abca6 Ace Arsg Ccdc47 Cyb561 Ddx42 Fam20a Ftsj3 Icam2 Kcnh6 LOC134480889 Mst1 Retreg2 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2
Bone volume	514.94	12	1	5.9	0.99	1.05e-14	Abca5 Abca6 Arsg Ccdc47 Cyb561 Fam20a Ftsj3 Icam2 Mst1 Retreg2 Taco1 Tlk2
Bone: connectivity density	838.02	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Bone: cortical apparent density	3012.38	4	1	5.9	-1	2.23e-03	Abca5 Abca6 LOC134480889 Retreg2
Bone: cortical area	2335.88	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: cortical porosity	29.92	16	1	5.9	-0.38	3.43e-02	Ace Ccdc47 Cyb561 Dcaf7 Ftsj3 Icam2 Kcnh6 LOC108352141 LOC134480889 Mrc2 Prr29 Retreg2 Scn4a Taco1 Tanc2 Tlk2
Bone: cortical porosity	61.1	11	1	5.9	0.98	5.60e-16	Cyb561 Dcaf7 Icam2 LOC108352141 LOC134480889 Mrc2 Prr29 Retreg2 Scn4a Taco1 Tlk2
Bone: cortical thickness	40.84	9	2	11.8	-0.84	1.48e-04	Abca5 Abca6 Arsg Fam20a Helz Icam2 Map2k6 Mst1 Retreg2
Bone: cortical thickness	1488.54	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: cortical tissue density	6506.29	2	1	5.9	0	1.00e+00	Abca5 Retreg2
Bone: elastic displacement	7604.03	1	1	5.9	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	89.73	39	35	205.9	0.99	2.35e-96	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: endosteal perimeter	116.87	38	37	217.6	0.98	3.92e-88	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: final force	840.18	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: final moment	146.88	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	93.45	39	35	205.9	0.98	8.75e-92	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: maximum diameter	140.48	24	2	11.8	0.99	1.20e-35	Abca5 Abca6 Ace Arsg Bptf Ccdc47 Cyb561 Dcaf7 Fam20a Ftsj3 Gna13 Helz Icam2 LOC120095203 LOC134480889 Mst1 Retreg2 Scn4a Shbg Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: maximum force	4390.32	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	3034.59	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	92.12	39	16	94.1	0.97	3.86e-77	Abca5 Abca6 Ace Arsg Bptf C10h17orf58 Ccdc47 Cyb561 Dcaf7 Ddx42 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kpna2 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Map3k3 Mrc2 Mst1 Pecam1 Polg2 Prr29 Retreg2 Rgs9 Scn4a Shbg Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: periosteal perimeter	165.84	28	2	11.8	0.97	1.31e-44	Abca5 Abca6 Ace Arsg C10h17orf58 Ccdc47 Cyb561 Dcaf7 Fam20a Gna13 Icam2 Kcnh6 LOC102550334 LOC108352141 LOC120095200 LOC120095203 LOC134480889 Map2k6 Mst1 Retreg2 Rgs9 Scn4a Shbg Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: post-yield work	6843.13	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	4554.23	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	5.9	0	1.00e+00	Retreg2
Bone: trabecular number	10739.78	1	1	5.9	0	1.00e+00	Retreg2
Bone: trabecular spacing	3991.76	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: trabecular thickness	4257.4	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	7288.79	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Breakpoint value in progressive ratio session	18809.48	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	50534.09	1	1	5.9	0	1.00e+00	Retreg2
Distance traveled after self-admin	32464.08	1	1	5.9	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	244.69	1	1	5.9	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	15131.21	1	1	5.9	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	18336.8	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Extinction: sum of active levers before priming	14221.72	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Active lever presses in extinction session 6	384.74	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Delta distance traveled before/after self-admin	2940.47	1	1	5.9	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	30849.75	1	1	5.9	0	1.00e+00	Retreg2
Time in closed arm before self-admin	13457.43	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Time in closed arm after self-admin	2326.29	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Time in open arm before self-admin	4379.48	2	1	5.9	0	1.00e+00	Mst1 Retreg2
Time in open arm after self-admin	277.78	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Sum of active levers in priming session hrs 5-6	978.69	1	1	5.9	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	6696.83	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Time to tail flick, vehicle, after self-admin	42142.71	1	1	5.9	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	8139.55	1	1	5.9	0	1.00e+00	Retreg2
Time to tail flick, test, after self-admin	1399.18	1	1	5.9	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	4924	2	2	11.8	0	1.00e+00	Mst1 Retreg2
Delta time to tail flick, test, before/after SA	15684.59	1	1	5.9	0	1.00e+00	Retreg2
Ambulatory time before self-admin	78874.38	1	1	5.9	0	1.00e+00	Retreg2
Ambulatory time after self-admin	26614.91	1	1	5.9	0	1.00e+00	Retreg2
Total heroin consumption	240.55	1	1	5.9	0	1.00e+00	Retreg2
Area under the delay curve	24791.27	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	21959.9	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	32437.06	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 4s delay	616.19	1	1	5.9	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	5.9	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	5.9	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	5.9	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	5.9	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	5669.94	1	1	5.9	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	13009.3	1	1	5.9	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	10785.17	1	1	5.9	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	5.9	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	22349.64	1	1	5.9	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	68821.85	1	1	5.9	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	5.9	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	71159.6	1	1	5.9	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	82029.05	1	1	5.9	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	99042.67	1	1	5.9	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	25503.09	1	1	5.9	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	8477.87	1	1	5.9	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	53555.35	1	1	5.9	0	1.00e+00	Retreg2
Weight adjusted by age	70782.25	1	1	5.9	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	13445.31	1	1	5.9	0	1.00e+00	Retreg2
Locomotion in novel chamber	3903.37	1	1	5.9	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	65422.89	1	1	5.9	0	1.00e+00	Retreg2
Progressive ratio	67888.93	1	1	5.9	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	1875.34	1	1	5.9	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	41283.25	1	1	5.9	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	5.9	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	7664.74	1	1	5.9	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	5.9	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	7166.92	1	1	5.9	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	1716.51	1	1	5.9	0	1.00e+00	Retreg2
Cd content in liver	11.83	1	0	0	0	1.00e+00	Shbg
Co content in liver	1133.25	1	1	5.9	0	1.00e+00	Retreg2
Cu content in liver	39.92	1	1	5.9	0	1.00e+00	Retreg2
Fe content in liver	1344.53	1	1	5.9	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	5.9	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	5.9	0	1.00e+00	Retreg2
Mn content in liver	1009.39	1	1	5.9	0	1.00e+00	Retreg2
Na content in liver	4018.36	1	1	5.9	0	1.00e+00	Retreg2
Rb content in liver	87.87	1	1	5.9	0	1.00e+00	Retreg2
Zn content in liver	3745.55	1	1	5.9	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.7
Adipose	alternative TSS	2	0.1	1.85
Adipose	gene expression	5	0.1	1.81
Adipose	isoform ratio	0	0	1.71
Adipose	intron excision ratio	0	0	2.09
Adipose	mRNA stability	1	0	1.76
BLA	alternative polyA	2	0.1	1.86
BLA	alternative TSS	0	0	1.78
BLA	gene expression	6	0.1	1.91
BLA	isoform ratio	0	0	1.74
BLA	intron excision ratio	1	0	1.82
BLA	mRNA stability	2	0.1	1.85
Brain	alternative polyA	0	0	1.74
Brain	alternative TSS	0	0	1.78
Brain	gene expression	5	0	1.82
Brain	isoform ratio	2	0	1.73
Brain	intron excision ratio	0	0	1.84
Brain	mRNA stability	2	0	1.75
Eye	alternative polyA	0	0	1.88
Eye	alternative TSS	0	0	2.04
Eye	gene expression	0	0	1.86
Eye	isoform ratio	0	0	2.02
Eye	intron excision ratio	0	0	1.79
Eye	mRNA stability	0	0	1.89
IC	alternative polyA	1	0.1	1.95
IC	alternative TSS	1	0.1	1.78
IC	gene expression	7	0.1	1.9
IC	isoform ratio	0	0	1.85
IC	intron excision ratio	0	0	1.88
IC	mRNA stability	1	0.1	1.88
IL	alternative polyA	0	0	1.84
IL	alternative TSS	1	0.1	1.67
IL	gene expression	4	0.1	1.87
IL	isoform ratio	1	0.1	1.82
IL	intron excision ratio	0	0	1.71
IL	mRNA stability	2	0.1	1.8
LHb	alternative polyA	0	0	1.72
LHb	alternative TSS	2	0.3	1.62
LHb	gene expression	2	0.1	1.82
LHb	isoform ratio	0	0	1.75
LHb	intron excision ratio	0	0	1.64
LHb	mRNA stability	1	0.1	1.8
Liver	alternative polyA	3	0.1	1.96
Liver	alternative TSS	4	0.1	1.88
Liver	gene expression	4	0	1.85
Liver	isoform ratio	3	0.1	1.87
Liver	intron excision ratio	2	0	1.93
Liver	mRNA stability	5	0.2	1.8
NAcc	alternative polyA	1	0	3.86
NAcc	alternative TSS	1	0	1.78
NAcc	gene expression	9	0.1	1.82
NAcc	isoform ratio	1	0	1.72
NAcc	intron excision ratio	1	0	1.77
NAcc	mRNA stability	1	0	1.87
OFC	alternative polyA	0	0	2.04
OFC	alternative TSS	2	0.3	1.84
OFC	gene expression	3	0.1	1.86
OFC	isoform ratio	0	0	1.73
OFC	intron excision ratio	0	0	1.62
OFC	mRNA stability	0	0	1.81
PL	alternative polyA	4	0.1	1.82
PL	alternative TSS	6	0.2	1.81
PL	gene expression	7	0.1	1.85
PL	isoform ratio	2	0	1.79
PL	intron excision ratio	1	0	1.78
PL	mRNA stability	0	0	1.82
pVTA	alternative polyA	0	0	1.81
pVTA	alternative TSS	0	0	1.83
pVTA	gene expression	7	0.1	1.89
pVTA	isoform ratio	0	0	1.76
pVTA	intron excision ratio	1	0	1.81
pVTA	mRNA stability	2	0.1	1.79
RMTg	alternative polyA	0	0	1.51
RMTg	alternative TSS	0	0	1.79
RMTg	gene expression	1	0.1	1.76
RMTg	isoform ratio	0	0	1.69
RMTg	intron excision ratio	0	0	1.87
RMTg	mRNA stability	0	0	1.79