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chr2:99,787,494-102,500,927

Best TWAS P=1.406089e-08 · Best GWAS P=1.139092e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Cyp7b1	gene expression	ENSRNOG00000009730	0.43	0.27	enet	71	0.29	5.8e-16	-5.6	5.5	2.9e-08	-0.92	0.51	0.49	FALSE
2	Brain	Cyp7b1	gene expression	ENSRNOG00000009730	0.32	0.27	enet	271	0.28	7.1e-26	-5.3	5.3	9.3e-08	-0.92	0.79	0.21	FALSE
3	Brain	Pde7a	gene expression	ENSRNOG00000013048	0.03	0.03	top1	1	0.03	3.9e-04	-5.2	-5.2	1.8e-07	0.85	0.06	0.05	FALSE
4	Brain	Bhlhe22	gene expression	ENSRNOG00000021745	0.07	0.04	top1	1	0.04	8.5e-05	-5.2	-5.2	2.5e-07	0.93	0.25	0.05	FALSE
5	Brain	Cyp7b1	intron excision ratio	chr2:100638373:100669465	0.04	0.02	enet	17	0.04	2.6e-04	-5.7	5.6	1.9e-08	-0.89	0.58	0.35	FALSE
6	Brain	Cyp7b1	intron excision ratio	chr2:100660904:100669465	0.04	0.02	enet	17	0.04	1.1e-04	-5.7	-5.5	4.3e-08	0.85	0.56	0.35	FALSE
7	Brain	Cyp7b1	mRNA stability	ENSRNOG00000009730	0.05	0.03	top1	1	0.03	7.4e-04	-5.3	5.3	1.1e-07	-0.89	0.10	0.04	FALSE
8	IL	Cyp7b1	gene expression	ENSRNOG00000009730	0.18	0.08	top1	1	0.08	6.5e-03	-5.3	5.3	1.1e-07	-0.87	0.12	0.05	FALSE
9	LHb	Armc1	gene expression	ENSRNOG00000013253	0.31	0.20	top1	1	0.20	1.4e-05	-5.4	-5.4	5.5e-08	0.93	0.09	0.09	FALSE
10	Liver	NA	mRNA stability	ENSRNOG00000066523	0.48	0.30	blup	2080	0.30	1.6e-33	-5.4	5.6	2.7e-08	-0.99	0.47	0.53	FALSE
11	NAcc2	Cyp7b1	gene expression	ENSRNOG00000009730	0.23	0.19	lasso	18	0.19	1.4e-10	-5.7	5.7	1.4e-08	-0.99	0.60	0.41	TRUE
12	NAcc2	Armc1	gene expression	ENSRNOG00000013253	0.19	0.04	top1	1	0.04	2.2e-03	-5.2	-5.2	1.6e-07	0.85	0.08	0.06	FALSE
13	NAcc2	Bhlhe22	gene expression	ENSRNOG00000021745	0.08	0.06	lasso	15	0.06	4.4e-04	-5.2	5.2	2.1e-07	-0.90	0.60	0.30	FALSE
14	PL2	Cyp7b1	gene expression	ENSRNOG00000009730	0.20	0.15	blup	2258	0.17	1.5e-09	-5.3	5.2	2.4e-07	-0.87	0.64	0.36	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.