Hub : Traits : Extensor digitorum longus weight : ← →

chr2:99,787,494-102,500,927

Trait: Extensor digitorum longus weight

Best TWAS P=1.872138e-08 · Best GWAS P=1.139092e-08 conditioned to 0.1162616

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Cyp7b1	gene expression	ENSRNOG00000009730	0.43	0.27	enet	71	0.29	5.8e-16	-5.6	5.5	2.9e-08	-0.92	0.51	0.49	FALSE
2	Brain	Cyp7b1	gene expression	ENSRNOG00000009730	0.32	0.27	enet	271	0.28	7.1e-26	-5.3	5.3	9.3e-08	-0.92	0.79	0.21	FALSE
3	Brain	Pde7a	gene expression	ENSRNOG00000013048	0.03	0.03	top1	1	0.03	3.9e-04	-5.2	-5.2	1.8e-07	0.85	0.06	0.05	FALSE
4	Brain	Bhlhe22	gene expression	ENSRNOG00000021745	0.07	0.04	top1	1	0.04	8.5e-05	-5.2	-5.2	2.5e-07	0.93	0.25	0.05	FALSE
5	Brain	Cyp7b1	intron excision ratio	chr2:100638373:100669465	0.04	0.02	enet	17	0.04	2.6e-04	-5.7	5.6	1.9e-08	-0.89	0.58	0.35	TRUE
6	Brain	Cyp7b1	intron excision ratio	chr2:100660904:100669465	0.04	0.02	enet	17	0.04	1.1e-04	-5.7	-5.5	4.3e-08	0.85	0.56	0.35	FALSE
7	Brain	Cyp7b1	mRNA stability	ENSRNOG00000009730	0.05	0.03	top1	1	0.03	7.4e-04	-5.3	5.3	1.1e-07	-0.89	0.10	0.04	FALSE
8	IL	Cyp7b1	gene expression	ENSRNOG00000009730	0.18	0.08	top1	1	0.08	6.5e-03	-5.3	5.3	1.1e-07	-0.87	0.12	0.05	FALSE
9	LHb	Armc1	gene expression	ENSRNOG00000013253	0.31	0.20	top1	1	0.20	1.4e-05	-5.4	-5.4	5.5e-08	0.93	0.09	0.09	FALSE
10	Liver	NA	mRNA stability	ENSRNOG00000066523	0.48	0.30	blup	2080	0.30	1.6e-33	-5.4	5.6	2.7e-08	-0.99	0.47	0.53	FALSE
11	NAcc	Mtfr1	gene expression	ENSRNOG00000021359	0.06	0.04	top1	1	0.04	3.3e-04	-5.5	-5.5	5.0e-08	0.92	0.06	0.08	FALSE
12	NAcc	Bhlhe22	gene expression	ENSRNOG00000021745	0.11	0.07	top1	1	0.07	6.0e-06	-5.2	5.2	1.7e-07	-0.92	0.37	0.09	FALSE
13	PL	Cyp7b1	gene expression	ENSRNOG00000009730	0.10	0.06	blup	2233	0.07	3.9e-06	-5.4	5.5	3.7e-08	-0.95	0.59	0.41	FALSE
14	PL	Armc1	gene expression	ENSRNOG00000013253	0.06	0.04	top1	1	0.04	5.1e-04	-5.3	-5.3	9.7e-08	0.86	0.07	0.08	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.