| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | gene expression | ENSRNOG00000068106 | 0.100 | 0.0757 | 1.5e-03 | 0.037 | 0.018 | 0.008 | 0.024 | 4.7e-03 | 3.4e-02 | 1.1e-01 | 1.9e-02 |
| 2 | Brain | gene expression | ENSRNOG00000068106 | 0.220 | 0.1100 | 1.1e-16 | 0.170 | 0.161 | 0.146 | 0.164 | 1.6e-15 | 8.8e-15 | 1.9e-13 | 5.1e-15 |
| 3 | NAcc | gene expression | ENSRNOG00000068106 | 0.034 | 0.0280 | 6.1e-03 | 0.008 | 0.008 | 0.005 | 0.001 | 7.3e-02 | 8.0e-02 | 1.2e-01 | 2.8e-01 |
| 4 | PL | gene expression | ENSRNOG00000068106 | 0.176 | 0.0919 | 1.6e-09 | 0.110 | 0.107 | 0.107 | 0.110 | 1.0e-08 | 1.6e-08 | 1.6e-08 | 9.8e-09 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 |
|---|---|---|---|---|---|---|---|
| Pavlov. Cond. magazine entry number | 12.9 | 16.1 | 17.5 | 4.2 | 3.5 | 4.2 | 4.2 |
| Pavlov. Cond. magazine entry latency | 10.0 | 12.9 | 14.1 | -3.8 | -3.0 | -3.8 | -3.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 9.4 | 11.8 | 13.1 | -3.6 | -2.9 | -3.6 | -3.6 |
| Pavlov. Cond. response bias | 9.3 | 11.4 | 12.6 | -3.5 | -2.9 | -3.5 | -3.5 |
| Pavlov. Cond. index score | 8.4 | 10.7 | 11.8 | -3.4 | -2.8 | -3.4 | -3.4 |
| Extensor digitorum longus weight | 8.3 | 33.5 | 36.7 | 5.7 | 6.1 | 5.6 | 5.7 |
| Pavlov. Cond. change in total contacts | 7.9 | 8.4 | 9.6 | -3.0 | -2.4 | -3.1 | -3.1 |
| Locomotion velocity, session 8 | 7.3 | 8.8 | 9.2 | 2.9 | 3.0 | 3.0 | 3.0 |
| Pavlov. Cond. latency score | 6.6 | 8.4 | 9.4 | -3.0 | -2.4 | -3.0 | -3.1 |
| Locomotion in novel chamber | 6.2 | 7.7 | 9.0 | -2.1 | -3.0 | -3.0 | -2.9 |
| Body weight | 6.1 | 25.9 | 27.4 | 5.1 | 4.8 | 5.2 | 5.2 |
| Bone: cortical apparent density | 5.8 | 7.6 | 8.3 | -2.9 | -2.5 | -2.8 | -2.8 |
| Bone: cortical tissue density | 5.8 | 7.5 | 8.3 | -2.9 | -2.5 | -2.8 | -2.8 |
| Bone: trabecular number | 5.6 | 8.7 | 9.5 | -2.9 | -3.1 | -2.9 | -3.0 |
| Locomotor testing rearing | 5.5 | 8.7 | 10.1 | -2.8 | -3.2 | -3.0 | -2.8 |
| Length without tail | 5.2 | 11.3 | 12.4 | 3.2 | 3.4 | 3.4 | 3.5 |
| Bone: cortical thickness | 4.9 | 5.8 | 6.6 | -2.6 | -2.0 | -2.6 | -2.5 |
| Delay discounting total patch changes 12 sec | 4.8 | 6.3 | 7.1 | -2.7 | -2.6 | -2.4 | -2.4 |
| Length with tail | 4.7 | 17.2 | 18.4 | 4.2 | 3.8 | 4.3 | 4.3 |
| Cocaine response after cond. not corrected | 4.5 | 5.0 | 5.5 | -2.3 | -2.2 | -2.3 | -2.2 |
| Delta time in closed arm before/after self-admin | 4.2 | 4.1 | 4.5 | 2.1 | 2.1 | 1.9 | 1.9 |
| Heart weight | 3.8 | 5.4 | 5.7 | 2.4 | 2.3 | 2.3 | 2.3 |
| Locomotion distance, session 1 | 3.6 | 4.6 | 5.6 | 2.3 | 1.5 | 2.4 | 2.3 |
| Stereotopy head waving bouts, day 3 | 3.6 | 4.3 | 4.4 | -2.1 | -2.0 | -2.0 | -2.1 |
| Time in open arm before self-admin | 3.3 | 3.5 | 5.1 | 2.2 | 1.5 | 1.8 | 1.9 |
| Ambulatory time after self-admin | 3.3 | 3.6 | 4.2 | 1.9 | 1.6 | 2.0 | 2.0 |
| Baseline Anxiety | 3.2 | 3.4 | 3.6 | -1.8 | -1.9 | -1.8 | -1.9 |
| Bone: connectivity density | 3.2 | 5.0 | 5.6 | -2.1 | -2.4 | -2.1 | -2.3 |
| Cocaine response after cond. corrected | 3.0 | 3.3 | 3.5 | -1.9 | -1.8 | -1.8 | -1.8 |
| Latency to leave start box in cocaine runway | 2.9 | 3.2 | 3.8 | 1.9 | 1.6 | 1.8 | 1.7 |
| Se content in liver | 2.9 | 3.5 | 4.5 | -1.8 | -2.1 | -1.8 | -1.7 |
| Locomotor testing distance | 2.8 | 4.6 | 4.9 | -2.2 | -2.0 | -2.2 | -2.2 |
| Intermitt. access day 15 inactive lever presses | 2.8 | 3.0 | 3.8 | -1.3 | -1.7 | -1.9 | -1.9 |
| Run reversals in cocaine runway, females | 2.8 | 2.8 | 3.2 | 1.7 | 1.8 | 1.6 | 1.6 |
| Pavlov. Cond. lever latency | 2.7 | 3.5 | 3.9 | 2.0 | 1.5 | 1.9 | 2.0 |
| Bone: apparent density | 2.6 | 4.2 | 4.7 | -2.0 | -2.2 | -2.0 | -2.1 |
| Delay disc. indifference point, 2s delay | 2.5 | 2.8 | 3.0 | -1.7 | -1.7 | -1.6 | -1.7 |
| Delay discounting total patch changes 24 sec | 2.4 | 3.0 | 3.2 | -1.7 | -1.6 | -1.8 | -1.8 |
| Short access day 1 locomotion | 2.4 | 2.5 | 2.6 | -1.6 | -1.6 | -1.6 | -1.6 |
| Pavlov. Cond. lever contacts | 2.4 | 2.8 | 3.4 | -1.8 | -1.1 | -1.8 | -1.8 |
| Delta time to tail flick, test, before/after SA | 2.4 | 2.1 | 2.6 | -1.2 | -1.4 | -1.6 | -1.6 |
| Time >=10cm from walls, locomotor time 2 | 2.4 | 2.5 | 3.2 | -1.3 | -1.8 | -1.6 | -1.6 |
| Left kidney weight | 2.3 | 6.5 | 7.5 | 2.7 | 2.3 | 2.6 | 2.6 |
| Latency to leave start box in cocaine runway, F | 2.3 | 2.5 | 2.8 | 1.7 | 1.4 | 1.7 | 1.6 |
| Bone: endosteal estimation | 2.2 | 4.8 | 5.7 | 2.3 | 1.6 | 2.4 | 2.4 |
| Cocaine induced anxiety | 2.1 | 2.4 | 2.5 | 1.6 | 1.6 | 1.5 | 1.6 |
| Total zone transitions, hab. session 1 | 2.1 | 3.0 | 3.2 | 1.7 | 1.6 | 1.8 | 1.8 |
| Bone: marrow area | 2.1 | 4.5 | 5.4 | 2.2 | 1.6 | 2.3 | 2.3 |
| Distance traveled after self-admin | 2.1 | 2.3 | 2.8 | 1.5 | 1.2 | 1.6 | 1.7 |
| Condit. Reinf. inactive responses | 1.9 | 2.3 | 2.6 | -1.6 | -1.5 | -1.6 | -1.4 |
| Bone: endosteal perimeter | 1.9 | 3.9 | 4.6 | 2.1 | 1.4 | 2.1 | 2.2 |
| Delay discounting total patch changes 6 sec | 1.8 | 2.8 | 4.0 | -1.6 | -2.0 | -1.6 | -1.5 |
| Light reinforcement 1 | 1.8 | 3.2 | 4.0 | -1.8 | -2.0 | -1.7 | -1.7 |
| Short access day 10 total locomotion | 1.8 | 2.0 | 2.4 | -1.4 | -1.5 | -1.2 | -1.5 |
| Bone: cortical thickness | 1.8 | 3.0 | 3.7 | -1.8 | -1.2 | -1.9 | -1.9 |
| BMI with tail | 1.7 | 5.4 | 5.7 | 2.4 | 2.3 | 2.3 | 2.3 |
| Pavlov. Cond. intertrial magazine entries | 1.7 | 2.2 | 2.5 | 1.4 | 1.6 | 1.4 | 1.6 |
| Degree of sensitization stereotypy | 1.7 | 1.9 | 2.2 | -1.4 | -1.1 | -1.5 | -1.5 |
| Zn content in liver | 1.7 | 1.9 | 2.5 | -1.3 | -1.6 | -1.3 | -1.3 |
| Intraocular pressure | 1.6 | 2.3 | 3.1 | 1.4 | 1.8 | 1.3 | 1.5 |
| Indifference point 0 sec | 1.6 | 2.6 | 3.7 | -1.5 | -1.9 | -1.5 | -1.4 |
| Progressive ratio test 1 active lever presses | 1.5 | 1.5 | 1.7 | -1.3 | -1.3 | -1.1 | -1.2 |
| Breakpoint value in progressive ratio session | 1.5 | 1.6 | 1.7 | 1.3 | 1.2 | 1.3 | 1.3 |
| Mean time between licks in bursts | 1.4 | 2.0 | 2.1 | 1.4 | 1.4 | 1.4 | 1.4 |
| Locomotion distance, session 8 | 1.4 | 2.0 | 2.5 | 1.5 | 1.0 | 1.6 | 1.6 |
| Pavlov. Cond. intertrial magazine entries | 1.4 | 1.7 | 2.0 | 1.4 | 1.1 | 1.3 | 1.3 |
| Co content in liver | 1.4 | 1.6 | 1.7 | 1.2 | 1.3 | 1.3 | 1.3 |
| Fe content in liver | 1.4 | 1.6 | 1.9 | 1.4 | 1.2 | 1.3 | 1.3 |
| Rb content in liver | 1.4 | 1.7 | 3.1 | -1.1 | -1.8 | -1.1 | -1.2 |
| Tibialis anterior weight | 1.3 | 4.5 | 5.5 | 2.2 | 2.3 | 1.9 | 2.0 |
| Times rat made contact with spout | 1.3 | 1.5 | 1.7 | -1.1 | -1.2 | -1.2 | -1.3 |
| Progressive ratio test 1 breakpoint | 1.3 | 1.3 | 1.9 | -1.4 | -1.2 | -1.0 | -1.1 |
| Incentive salience index mean | 1.3 | 1.6 | 1.7 | -1.2 | -1.2 | -1.3 | -1.3 |
| Novel to familiar place preference ratio | 1.3 | 1.3 | 1.4 | 1.2 | 1.1 | 1.1 | 1.2 |
| Bone: final force | 1.3 | 2.1 | 2.3 | -1.5 | -1.5 | -1.3 | -1.4 |
| Delay disc. indifference point, 0s delay | 1.3 | 1.4 | 1.6 | -1.1 | -1.2 | -1.3 | -1.2 |
| Rest time, locomotor task time 2 | 1.3 | 1.5 | 1.8 | 1.3 | 1.2 | 1.2 | 1.2 |
| Conditioned reinforcement - actives | 1.2 | 1.2 | 1.6 | -1.2 | -1.1 | -0.9 | -1.1 |
| Progressive ratio test 2 active lever presses | 1.2 | 1.2 | 1.5 | -1.0 | -1.2 | -1.1 | -1.1 |
| Time in closed arm before self-admin | 1.2 | 1.4 | 1.9 | -1.4 | -1.2 | -1.1 | -1.0 |
| Delay discounting total patch changes 0 sec | 1.1 | 1.8 | 3.0 | -1.2 | -1.7 | -1.2 | -1.2 |
| Reaction time false alarm rate | 1.1 | 1.5 | 1.9 | -1.4 | -1.1 | -1.3 | -1.2 |
| Conditioned locomotion | 1.1 | 1.3 | 1.6 | -1.1 | -1.1 | -1.1 | -1.2 |
| Incentive Sensitization - Responses | 1.1 | 1.1 | 1.5 | -0.9 | -1.0 | -1.2 | -1.1 |
| Incentive Sensitization - Breakpoint | 1.1 | 1.1 | 1.5 | -0.8 | -1.0 | -1.2 | -1.1 |
| Bone: post-yield work | 1.1 | 1.4 | 1.6 | 1.2 | 1.2 | 1.2 | 1.2 |
| Mn content in liver | 1.1 | 1.3 | 3.1 | -0.8 | -1.8 | -0.8 | -0.8 |
| Pavlov. Cond. response bias | 1.0 | 1.4 | 1.5 | -1.1 | -1.2 | -1.2 | -1.2 |
| Progressive ratio test 2 breakpoint | 1.0 | 1.1 | 1.2 | -1.0 | -1.0 | -1.1 | -1.1 |
| Short access day 1 total inactive lever presses | 1.0 | 1.1 | 1.4 | -1.2 | -1.0 | -1.0 | -1.1 |
| Stereotopy head waving bouts, day 7 | 1.0 | 1.2 | 1.4 | -1.1 | -0.8 | -1.1 | -1.2 |
| Condit. Reinf. lever presses | 1.0 | 1.3 | 1.5 | -1.2 | -1.0 | -1.2 | -1.2 |
| Bone: final moment | 1.0 | 1.7 | 1.9 | -1.4 | -1.3 | -1.2 | -1.3 |
| Bone: trabecular spacing | 1.0 | 1.3 | 1.3 | 1.1 | 1.1 | 1.1 | 1.2 |
| Delta distance traveled before/after self-admin | 1.0 | 1.1 | 1.3 | 1.0 | 0.8 | 1.1 | 1.1 |
| Tail length | 0.9 | 2.7 | 3.6 | 1.9 | 1.3 | 1.7 | 1.7 |
| Extinction: sum of active levers before priming | 0.9 | 0.9 | 1.0 | 1.0 | 0.9 | 1.0 | 0.9 |
| Time >=10cm from walls, locomotor time 1 | 0.9 | 0.9 | 1.0 | -1.0 | -1.0 | -0.9 | -0.9 |
| Total resting periods, locomotor time 1 | 0.9 | 1.0 | 1.3 | 0.7 | 1.1 | 1.0 | 1.1 |
| Locomotion in novel chamber post-restriction | 0.9 | 1.1 | 1.4 | -1.0 | -1.2 | -0.9 | -1.0 |
| Tibia length | 0.8 | 2.2 | 3.0 | 1.4 | 1.7 | 1.4 | 1.4 |
| Food consumed during 24 hour testing period | 0.8 | 1.0 | 1.0 | 0.9 | 1.0 | 1.0 | 1.0 |
| Reaction time number correct | 0.8 | 1.1 | 1.2 | 1.1 | 1.1 | 1.0 | 0.9 |
| Reaction time trials correct on left | 0.8 | 1.1 | 1.2 | 1.1 | 1.1 | 1.0 | 0.9 |
| Cocaine response before conditioning | 0.8 | 1.0 | 1.3 | -1.1 | -0.8 | -1.1 | -0.9 |
| Condit. Reinf. active responses | 0.8 | 1.1 | 1.3 | -1.1 | -1.0 | -1.1 | -1.0 |
| Pavlov. Cond. lever contacts | 0.8 | 1.1 | 1.2 | -1.0 | -1.0 | -1.1 | -1.1 |
| Conditioned reinforcement - inactives | 0.8 | 0.9 | 1.1 | -1.0 | -1.0 | -0.9 | -1.0 |
| Short access day 10 total inactive lever presses | 0.8 | 0.9 | 1.2 | 0.7 | 1.1 | 1.0 | 0.9 |
| Locomotion distance, session 2 | 0.8 | 1.1 | 1.5 | 1.2 | 0.4 | 1.2 | 1.2 |
| Locomotion velocity, session 7 | 0.8 | 0.9 | 1.1 | 1.0 | 0.9 | 0.9 | 1.0 |
| Time in novel zone, hab. session 1 | 0.8 | 0.8 | 0.9 | -0.9 | -0.9 | -0.8 | -0.8 |
| Novelty place preference | 0.8 | 0.9 | 1.1 | 0.9 | 1.0 | 0.9 | 0.9 |
| Time to tail flick, test, before self-admin | 0.8 | 0.8 | 0.9 | 0.8 | 0.9 | 0.9 | 1.0 |
| Area under the delay curve | 0.8 | 0.8 | 1.0 | -0.9 | -1.0 | -0.8 | -0.9 |
| Delay disc. indifference point, 4s delay | 0.8 | 0.8 | 1.2 | -0.6 | -1.1 | -0.9 | -1.0 |
| K content in liver | 0.8 | 0.8 | 1.8 | -0.6 | -1.3 | -0.7 | -0.7 |
| Glucose | 0.7 | 1.1 | 1.1 | -1.0 | -1.1 | -1.0 | -1.1 |
| Number of licking bursts | 0.7 | 0.8 | 0.9 | -0.8 | -0.8 | -0.9 | -0.9 |
| Delay discounting total patch changes 18 sec | 0.7 | 0.9 | 1.2 | -1.0 | -1.1 | -0.8 | -0.7 |
| Delay discounting water rate 6 sec | 0.7 | 1.0 | 1.1 | -1.1 | -0.9 | -1.0 | -1.0 |
| Reaction time num false alarms | 0.7 | 1.0 | 1.1 | -1.0 | -0.9 | -1.0 | -1.0 |
| Reaction time trials on left | 0.7 | 1.0 | 1.2 | 1.1 | 1.1 | 1.0 | 0.9 |
| Reaction time omissions | 0.7 | 1.0 | 1.2 | -1.1 | -0.9 | -1.0 | -1.1 |
| Reaction time trials completed | 0.7 | 1.0 | 1.2 | 1.1 | 1.1 | 1.0 | 0.9 |
| Condit. Reinf. lever reinforcers received | 0.7 | 1.1 | 1.2 | -1.0 | -1.0 | -1.1 | -1.0 |
| Progressive ratio test 1 inactive lever presses | 0.7 | 0.8 | 1.0 | -1.0 | -0.8 | -0.8 | -0.9 |
| Total sessions with >9 infusions | 0.7 | 0.8 | 1.2 | -1.1 | -0.9 | -0.7 | -0.8 |
| Locomotion velocity, session 1 | 0.7 | 0.8 | 1.1 | 1.0 | 0.6 | 0.9 | 0.9 |
| Condit. Reinf. active responses | 0.7 | 0.8 | 1.0 | -0.9 | -0.7 | -1.0 | -1.0 |
| Locomotion velocity, hab. session 1 | 0.7 | 1.0 | 1.2 | 0.9 | 1.0 | 1.1 | 0.9 |
| Bone: cortical porosity | 0.7 | 0.8 | 1.0 | -1.0 | -0.4 | -1.0 | -1.0 |
| Bone: periosteal perimeter | 0.7 | 1.1 | 1.3 | 1.1 | 0.9 | 1.1 | 1.1 |
| Time in open arm after self-admin | 0.7 | 0.8 | 1.0 | 1.0 | 0.9 | 0.9 | 0.7 |
| Ambulatory time before self-admin | 0.7 | 0.7 | 1.3 | 1.1 | 0.7 | 0.7 | 0.8 |
| Delay disc. indifference point, 16s delay | 0.7 | 0.8 | 0.8 | -0.9 | -0.9 | -0.8 | -0.8 |
| Run reversals in cocaine runway, males | 0.7 | 0.7 | 1.0 | -0.2 | -1.0 | -0.9 | -0.9 |
| Cu content in liver | 0.7 | 0.9 | 1.3 | 1.0 | 0.2 | 1.2 | 1.0 |
| Locomotor activity | 0.6 | 1.0 | 1.1 | -1.0 | -0.8 | -1.0 | -1.1 |
| Light reinforcement 2 | 0.6 | 0.8 | 1.0 | -0.9 | -1.0 | -0.8 | -0.8 |
| Reaction time trials AUC | 0.6 | 0.8 | 1.0 | 1.0 | 1.0 | 0.8 | 0.8 |
| Intermitt. access escalation Index | 0.6 | 0.5 | 0.7 | 0.6 | 0.7 | 0.8 | 0.7 |
| Locomotion velocity, session 2 | 0.6 | 0.7 | 0.9 | 1.0 | 0.7 | 0.9 | 0.9 |
| Total zone transitions, hab. session 2 | 0.6 | 0.8 | 0.9 | 0.9 | 0.6 | 0.9 | 0.9 |
| Bone: cortical porosity | 0.6 | 0.7 | 0.8 | -0.9 | -0.5 | -0.9 | -0.9 |
| Diff in mean of infusions in LGA sessions | 0.6 | 0.6 | 0.8 | 0.6 | 0.7 | 0.9 | 0.9 |
| Time in closed arm after self-admin | 0.6 | 0.7 | 0.8 | 0.8 | 0.7 | 0.7 | 0.9 |
| Delay discount hyperbolic model param | 0.6 | 0.7 | 0.8 | 0.8 | 0.9 | 0.7 | 0.8 |
| Bouts of movement, locomotor time 1 | 0.6 | 0.7 | 0.9 | 0.6 | 1.0 | 0.8 | 0.9 |
| Mg content in liver | 0.6 | 0.6 | 1.0 | -0.6 | -1.0 | -0.7 | -0.7 |
| Soleus weight | 0.5 | 1.3 | 1.8 | -1.2 | -0.6 | -1.3 | -1.3 |
| Reaction time num false alarms AUC | 0.5 | 0.7 | 0.9 | -0.9 | -0.7 | -0.9 | -0.8 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.6 | 0.7 | -0.7 | -0.7 | -0.8 | -0.7 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.6 | 0.8 | -0.7 | -0.9 | -0.8 | -0.8 |
| Intermittent access day 15 total locomotion | 0.5 | 0.5 | 0.7 | -0.5 | -0.8 | -0.7 | -0.8 |
| Intermittent access total locomotion | 0.5 | 0.6 | 0.8 | -0.7 | -0.8 | -0.7 | -0.9 |
| Context. condit. distance diff. score | 0.5 | 0.6 | 0.9 | 0.6 | 1.0 | 0.7 | 0.7 |
| Locomotion distance, session 3 | 0.5 | 0.5 | 0.6 | 0.8 | 0.6 | 0.7 | 0.8 |
| Condit. Reinf. active-inactive response ratio | 0.5 | 0.6 | 0.7 | -0.8 | -0.7 | -0.8 | -0.8 |
| Condit. Reinf. inactive responses | 0.5 | 0.6 | 0.8 | -0.9 | -0.0 | -0.9 | -0.9 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 0.6 | -0.8 | -0.8 | -0.6 | -0.7 |
| Epididymis fat weight | 0.4 | 0.9 | 1.2 | 0.8 | 0.8 | 1.1 | 1.1 |
| Right kidney weight | 0.4 | 1.3 | 1.4 | 1.1 | 1.1 | 1.2 | 1.2 |
| Parametrial fat weight | 0.4 | 0.7 | 0.9 | -1.0 | -0.9 | -0.8 | -0.7 |
| Delay discounting water rate 18 sec | 0.4 | 0.5 | 0.8 | -0.6 | -0.4 | -0.7 | -0.9 |
| Intermitt. access day 1 inactive lever presses | 0.4 | 0.5 | 0.9 | -0.9 | -0.4 | -0.6 | -0.6 |
| Stereotopy head waving duration, day 3 | 0.4 | 0.5 | 0.7 | -0.8 | -0.6 | -0.7 | -0.8 |
| Degree of sensitization distance | 0.4 | 0.4 | 0.7 | 0.4 | 0.9 | 0.6 | 0.6 |
| Condit. Reinf. active minus inactive responses | 0.4 | 0.4 | 0.5 | -0.6 | -0.7 | -0.7 | -0.7 |
| Time in familiar zone, hab. session 1 | 0.4 | 0.3 | 0.5 | -0.6 | -0.3 | -0.7 | -0.7 |
| Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 0.5 | -0.6 | -0.7 | -0.6 | -0.6 |
| Locomotion velocity, hab. session 2 | 0.4 | 0.5 | 0.7 | 0.7 | 0.8 | 0.7 | 0.7 |
| Bone: minimum diameter | 0.4 | 0.8 | 1.0 | 0.9 | 0.4 | 1.0 | 1.0 |
| Bone: tissue strength | 0.4 | 0.4 | 0.7 | 0.5 | 0.8 | 0.5 | 0.5 |
| Distance traveled before self-admin | 0.4 | 0.4 | 0.8 | 0.9 | 0.5 | 0.5 | 0.6 |
| Total heroin consumption | 0.4 | 0.5 | 0.7 | -0.4 | -0.9 | -0.7 | -0.7 |
| Delay discount exponential model param | 0.4 | 0.4 | 0.5 | 0.6 | 0.7 | 0.6 | 0.7 |
| Na content in liver | 0.4 | 0.4 | 0.7 | -0.6 | -0.8 | -0.5 | -0.5 |
| Delay discounting water rate 12 sec | 0.3 | 0.4 | 0.6 | 0.8 | 0.8 | 0.6 | 0.5 |
| Median of all reaction times | 0.3 | 0.4 | 0.6 | -0.5 | -0.4 | -0.8 | -0.8 |
| Saline control response | 0.3 | 0.4 | 0.5 | -0.7 | -0.5 | -0.6 | -0.6 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.4 | -0.5 | -0.6 | -0.4 | -0.6 |
| Short access total locomotion | 0.3 | 0.3 | 0.5 | -0.7 | -0.5 | -0.3 | -0.5 |
| Stereotopy head waving duration, day 7 | 0.3 | 0.3 | 0.4 | -0.6 | -0.4 | -0.6 | -0.7 |
| Total zone transitions, NPP test | 0.3 | 0.4 | 0.5 | 0.7 | 0.3 | 0.7 | 0.7 |
| Active lever presses in extinction session 6 | 0.3 | 0.3 | 0.5 | -0.3 | -0.7 | -0.5 | -0.5 |
| Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 0.4 | 0.3 | 0.5 | 0.7 | 0.6 |
| Sum of active levers in priming session hrs 5-6 | 0.3 | 0.3 | 0.4 | -0.5 | -0.6 | -0.5 | -0.6 |
| Delta time to tail flick, vehicle, before/after SA | 0.3 | 0.3 | 0.5 | -0.7 | -0.4 | -0.6 | -0.5 |
| Food seeking constrained by brief footshock | 0.3 | 0.4 | 0.7 | -0.8 | -0.6 | -0.4 | -0.4 |
| Latency to leave start box in cocaine runway, M | 0.3 | 0.3 | 0.6 | 0.7 | 0.4 | 0.4 | 0.4 |
| Std. dev. time between licks in bursts | 0.2 | 0.2 | 0.4 | 0.6 | 0.4 | 0.5 | 0.4 |
| Reaction time mean minus median AUC | 0.2 | 0.2 | 0.4 | -0.5 | -0.1 | -0.6 | -0.5 |
| Reaction time premature initiation rate | 0.2 | 0.3 | 0.7 | -0.8 | -0.4 | -0.5 | -0.5 |
| Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.5 | -0.5 |
| Pavlov. Cond. lever latency | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | 0.5 | 0.6 |
| Pavlov. Cond. index score | 0.2 | 0.3 | 0.4 | -0.5 | -0.6 | -0.6 | -0.6 |
| Intermittent access terminal intake (last 3 days) | 0.2 | 0.2 | 0.3 | -0.6 | -0.5 | -0.5 | -0.4 |
| Short access day 10 total infusions | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.3 | -0.4 |
| Locomotion velocity, session 3 | 0.2 | 0.2 | 0.3 | 0.5 | 0.2 | 0.5 | 0.5 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.4 | 0.4 | 0.6 | 0.4 | 0.4 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.4 | 0.4 | 0.7 | 0.4 | 0.4 |
| Locomotion velocity, NPP test | 0.2 | 0.3 | 0.5 | 0.6 | 0.4 | 0.7 | 0.6 |
| Bone volume | 0.2 | 0.3 | 0.5 | -0.4 | -0.7 | -0.4 | -0.5 |
| Bone: cortical area | 0.2 | 0.4 | 0.4 | -0.6 | -0.5 | -0.6 | -0.7 |
| Bone: periosteal estimation | 0.2 | 0.4 | 0.5 | 0.6 | 0.3 | 0.7 | 0.7 |
| Time to tail flick, vehicle, before self-admin | 0.2 | 0.2 | 0.2 | -0.5 | -0.5 | -0.4 | -0.4 |
| Time to tail flick, vehicle, after self-admin | 0.2 | 0.2 | 0.2 | -0.4 | -0.4 | -0.5 | -0.4 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 0.3 | 0.6 | 0.4 | 0.4 | 0.3 |
| Distance moved, locomotor task time 1 | 0.2 | 0.2 | 0.2 | -0.4 | -0.5 | -0.4 | -0.5 |
| Seeking ratio, punishment vs. effort | 0.2 | 0.3 | 0.5 | -0.7 | -0.3 | -0.6 | -0.5 |
| BMI without tail | 0.1 | 0.1 | 0.4 | 0.6 | 0.2 | 0.3 | 0.3 |
| Liver weight, left | 0.1 | 0.1 | 0.2 | 0.5 | 0.2 | 0.4 | 0.3 |
| Retroperitoneal fat weight | 0.1 | 0.4 | 0.6 | 0.5 | 0.4 | 0.8 | 0.8 |
| Delay discounting water rate 24 sec | 0.1 | 0.2 | 0.4 | -0.4 | -0.3 | -0.4 | -0.6 |
| Reaction time mean minus median | 0.1 | 0.2 | 0.4 | 0.3 | 0.6 | 0.2 | 0.3 |
| Reaction time premature initiations | 0.1 | 0.1 | 0.2 | 0.0 | 0.4 | 0.3 | 0.3 |
| Social responses | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.3 | -0.2 |
| Conditioned locomotion | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.2 | -0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.2 | 0.2 | -0.3 | -0.4 | -0.4 | -0.5 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.2 | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.2 | -0.3 | -0.4 | -0.4 | -0.4 |
| Intermittent access intake day 1-15 change | 0.1 | 0.1 | 0.1 | -0.3 | -0.1 | -0.3 | -0.2 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.3 | 0.5 | 0.3 | 0.1 | 0.3 |
| Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.2 | -0.3 |
| Intermittent access day 15 total infusions | 0.1 | 0.2 | 0.2 | -0.4 | -0.5 | -0.3 | -0.4 |
| Intermittent access standard deviation | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | -0.5 | -0.3 |
| Progressive ratio test 2 inactive lever presses | 0.1 | 0.1 | 0.1 | 0.2 | -0.3 | -0.2 | -0.3 |
| Short access day 1 total infusions | 0.1 | 0.1 | 0.1 | -0.4 | -0.2 | -0.2 | -0.2 |
| Compulsive drug intake | 0.1 | 0.1 | 0.1 | -0.1 | 0.3 | 0.3 | 0.3 |
| One hour access (shock baseline) | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | -0.3 | -0.3 |
| Locomotion distance, session 7 | 0.1 | 0.2 | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 |
| Total locomotion distance, hab. session 1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.4 | 0.3 | 0.2 |
| Bone: maximum force | 0.1 | 0.1 | 0.1 | -0.4 | -0.3 | -0.2 | -0.3 |
| Bone: stiffness | 0.1 | 0.1 | 0.3 | -0.4 | -0.5 | -0.2 | -0.3 |
| Delta time in open arm before/after self-admin | 0.1 | 0.1 | 0.1 | -0.3 | -0.1 | -0.2 | -0.3 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | -0.4 | -0.4 |
| Delay disc. indifference point, 24s delay | 0.1 | 0.1 | 0.1 | -0.4 | -0.3 | -0.2 | -0.4 |
| Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.2 | -0.3 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.2 | 0.5 | 0.0 | 0.2 | 0.1 |
| Weight adjusted by age | 0.1 | 0.1 | 0.1 | 0.4 | 0.3 | 0.3 | 0.4 |
| Cd content in liver | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | -0.2 | -0.2 |
| Sr content in liver | 0.1 | 0.1 | 0.2 | 0.4 | 0.0 | 0.4 | 0.4 |
| Liver weight, right | 0.0 | 0.1 | 0.2 | -0.2 | -0.4 | -0.1 | -0.1 |
| Mean num. licks in bursts | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | -0.0 | -0.1 |
| Water consumed over 24 hours | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.0 | -0.0 |
| Indifference point AUC | 0.0 | 0.0 | 0.1 | -0.0 | -0.3 | 0.0 | 0.1 |
| Indifference point function ln k | 0.0 | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | -0.2 |
| Indifference point function log k | 0.0 | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | -0.2 |
| Delay discounting time to switch 0 sec | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.2 | -0.2 |
| Delay discounting water rate 0 sec | 0.0 | 0.0 | 0.0 | 0.2 | 0.0 | 0.2 | 0.1 |
| Reaction time mean | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.3 | -0.2 |
| Reaction time mean AUC | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | -0.1 |
| Std. dev. reaction times | 0.0 | 0.0 | 0.1 | -0.1 | 0.3 | -0.2 | -0.1 |
| Social response proportion | 0.0 | 0.0 | 0.1 | -0.1 | 0.3 | -0.1 | -0.0 |
| Social time | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.1 |
| Condit. Reinf. lever presses | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | -0.2 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | 0.0 |
| Intermittent access intake escalation | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | -0.2 | -0.1 |
| Intermittent access total infusions | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | 0.1 | 0.0 |
| Post-drug Anxiety | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 |
| Lifetime Intake | 0.0 | 0.0 | 0.0 | -0.1 | 0.0 | 0.1 | 0.1 |
| Short access total infusions | 0.0 | 0.0 | 0.0 | -0.2 | 0.1 | 0.2 | 0.1 |
| One hour access (0.3 mA shock) | 0.0 | 0.0 | 0.1 | -0.3 | -0.0 | 0.0 | 0.0 |
| Number of responses in last shaping day | 0.0 | 0.0 | 0.0 | 0.2 | 0.1 | -0.1 | 0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.2 | -0.3 |
| Total locomotion distance, NPP test | 0.0 | 0.0 | 0.0 | -0.1 | -0.2 | -0.0 | -0.1 |
| Bone surface | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.1 | -0.0 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.2 | -0.1 |
| Bone: elastic work | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 |
| Bone: maximum diameter | 0.0 | 0.0 | 0.1 | -0.1 | -0.3 | -0.2 | -0.1 |
| Bone: maximum moment | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.1 | -0.2 |
| Bone: trabecular thickness | 0.0 | 0.1 | 0.1 | -0.2 | -0.1 | -0.2 | -0.3 |
| Bone: trabecular tissue density | 0.0 | 0.0 | 0.0 | -0.1 | 0.2 | -0.1 | -0.1 |
| Rest time, locomotor task time 1 | 0.0 | 0.0 | 0.0 | -0.2 | -0.0 | -0.0 | 0.1 |
| Bouts of movement, locomotor time 2 | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | -0.3 | -0.1 |
| Total resting periods, locomotor time 2 | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | -0.0 | 0.1 |
| Distance moved, locomotor task time 2 | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.2 | -0.1 |
| Vertical activity count, locomotor time 2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | 0.2 |
| Seeking ratio, delayed vs. immediate footshock | 0.0 | 0.0 | 0.0 | 0.2 | -0.0 | -0.1 | -0.0 |
| Progressive ratio | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.0 | 0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.