Hub : Genes

Arhgap23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000022771	0.08	0.06	2.1e-07	0.06	0.06	0.06	0.06	2.6e-07	7.0e-07	2.7e-07	4.6e-07
2	Adipose	mRNA stability	ENSRNOG00000022771	0.04	0.03	5.7e-05	0.03	0.03	0.02	0.03	3.7e-04	4.8e-04	9.2e-04	4.7e-04
3	BLA	gene expression	ENSRNOG00000022771	0.12	0.08	1.9e-03	-0	0.02	0.02	0.01	5.0e-01	4.7e-02	3.7e-02	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	3.9	12.7	31.1	-1.8	2.0	-5.6
BMI without tail	0.4	0.8	1.9	-0.5	0.5	-1.4
Body weight	5.1	21.7	23.3	-4.4	4.8	-4.7
Epididymis fat weight	0.2	0.4	0.6	-0.8	0.5	-0.6
Glucose	0.3	0.5	0.8	0.8	-0.9	-0.2
Heart weight	2.8	4.0	4.7	-2.0	1.8	-2.2
Left kidney weight	2.5	7.1	8.5	-2.9	2.8	-2.2
Right kidney weight	0.9	2.6	3.4	-1.5	1.4	-1.9
Tail length	1.4	4.2	4.7	-2.0	2.0	2.2
Length with tail	3.4	12.4	18.7	-4.3	4.3	-0.3
Length without tail	3.5	7.7	9.1	-3.0	3.0	-2.2
Liver weight, left	0.2	0.3	0.4	-0.6	0.3	0.6
Liver weight, right	0.2	0.3	0.7	-0.2	-0.2	0.9
Parametrial fat weight	0.9	1.8	2.2	1.5	-1.3	1.2
Retroperitoneal fat weight	0.1	0.3	0.8	-0.2	0.3	-0.9
Intraocular pressure	0.8	1.1	2.2	-1.5	1.1	0.0
Extensor digitorum longus weight	7.1	28.7	32.3	-5.4	5.7	-4.9
Soleus weight	0.3	1.0	1.6	1.3	-1.1	-0.1
Tibialis anterior weight	1.1	3.7	4.9	-2.2	2.2	-1.3
Tibia length	1.1	3.1	4.1	-1.7	1.6	-2.0
Number of licking bursts	0.4	0.5	0.6	0.7	-0.7	0.8
Food consumed during 24 hour testing period	0.9	1.1	1.8	-1.2	1.3	-0.1
Times rat made contact with spout	0.6	0.7	0.8	0.8	-0.8	0.9
Mean time between licks in bursts	1.1	1.5	1.7	-1.1	1.3	-1.3
Mean num. licks in bursts	0.0	0.0	0.1	0.1	-0.1	0.2
Std. dev. time between licks in bursts	0.6	0.8	1.8	-0.4	0.6	-1.3
Water consumed over 24 hours	0.1	0.1	0.2	0.2	0.1	0.4
Indifference point 0 sec	1.1	1.7	3.0	1.7	-1.4	0.3
Indifference point AUC	0.3	0.4	0.6	-0.8	0.6	-0.3
Indifference point function ln k	0.0	0.1	0.1	0.3	-0.3	0.1
Indifference point function log k	0.0	0.1	0.1	0.3	-0.3	0.1
Delay discounting total patch changes 0 sec	0.7	1.1	2.0	1.4	-1.1	0.0
Delay discounting total patch changes 12 sec	3.1	4.2	5.9	2.4	-2.2	1.3
Delay discounting total patch changes 18 sec	0.3	0.3	0.5	0.6	-0.4	-0.7
Delay discounting total patch changes 24 sec	0.7	0.9	1.5	1.2	-1.1	0.0
Delay discounting total patch changes 6 sec	0.6	0.9	1.7	1.3	-1.0	-0.0
Delay discounting time to switch 0 sec	0.1	0.2	0.3	0.5	-0.3	0.2
Delay discounting water rate 0 sec	0.3	0.5	1.1	-0.5	0.2	-1.1
Delay discounting water rate 12 sec	0.3	0.5	0.8	-0.9	0.8	-0.4
Delay discounting water rate 18 sec	0.8	1.0	1.6	0.7	-1.0	1.3
Delay discounting water rate 24 sec	0.2	0.3	0.6	0.6	-0.8	-0.0
Delay discounting water rate 6 sec	0.5	0.8	1.2	0.6	-1.1	0.8
Locomotor activity	0.4	0.6	1.1	1.0	-0.9	-0.1
Locomotor testing distance	2.6	4.3	6.1	2.5	-2.4	0.9
Locomotor testing rearing	4.0	6.3	8.7	2.5	-2.9	2.0
Light reinforcement 1	1.8	3.3	4.6	2.1	-2.0	1.2
Light reinforcement 2	0.5	0.7	0.9	1.0	-0.9	0.5
Reaction time number correct	0.4	0.6	1.1	-0.7	1.0	-0.4
Reaction time mean minus median	0.0	0.0	0.1	0.3	0.1	0.1
Reaction time mean minus median AUC	0.6	0.8	1.3	1.1	-0.7	0.8
Reaction time num false alarms	0.9	1.2	1.4	0.9	-1.2	1.2
Reaction time num false alarms AUC	0.7	1.0	1.3	0.8	-1.0	1.1
Reaction time trials correct on left	0.4	0.6	1.1	-0.7	1.0	-0.4
Reaction time trials on left	0.4	0.5	1.0	-0.7	1.0	-0.4
Reaction time mean	0.1	0.1	0.1	0.3	0.0	-0.4
Reaction time mean AUC	0.0	0.1	0.1	0.2	0.1	-0.3
Median of all reaction times	0.1	0.2	0.3	0.6	-0.4	-0.2
Reaction time omissions	0.6	0.8	1.1	1.0	-1.0	0.7
Reaction time false alarm rate	1.1	1.5	2.2	1.1	-1.5	1.1
Reaction time premature initiation rate	0.5	0.7	0.9	1.0	-0.5	0.9
Reaction time premature initiations	0.1	0.2	0.3	0.3	0.3	0.5
Std. dev. reaction times	0.1	0.1	0.2	0.5	-0.1	0.0
Reaction time trials completed	0.4	0.5	1.0	-0.7	1.0	-0.4
Reaction time trials AUC	0.3	0.4	0.8	-0.6	0.9	-0.2
Social response proportion	0.3	0.3	0.6	0.5	-0.2	0.8
Social responses	0.2	0.2	0.3	0.5	-0.4	0.5
Social time	0.0	0.0	0.0	0.0	-0.0	0.1
Conditioned locomotion	0.2	0.2	0.3	0.5	-0.4	-0.5
Cocaine response after cond. corrected	1.3	1.4	2.1	1.4	-1.3	-0.7
Cocaine response after cond. not corrected	2.0	2.2	3.4	1.8	-1.8	0.1
Cocaine response before conditioning	1.8	2.2	3.9	0.9	-1.3	2.0
Saline control response	0.7	0.9	1.1	1.1	-0.8	1.0
Condit. Reinf. active minus inactive responses	0.7	0.9	1.4	1.2	-0.9	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.7	-0.4	0.1
Condit. Reinf. active responses	1.2	1.7	2.2	1.5	-1.4	1.0
Condit. Reinf. inactive responses	2.7	3.4	3.7	1.9	-1.9	1.7
Condit. Reinf. lever presses	0.3	0.4	0.7	0.5	-0.3	0.9
Condit. Reinf. lever reinforcers received	1.2	1.8	2.2	1.5	-1.3	1.2
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.6	0.5	0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.2	0.2	0.4
Pavlov. Cond. change in total contacts	0.4	0.6	1.0	1.0	-0.8	0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	-0.4	-0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	0.3	-0.3	-0.0
Pavlov. Cond. lever contacts	0.6	0.8	1.4	1.2	-1.1	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.8	-1.3	1.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.3	-0.2	-0.2
Pavlov. Cond. response bias	0.7	1.0	1.6	1.2	-1.1	0.3
Conditioned reinforcement - actives	1.8	1.8	2.6	1.6	-1.6	0.5
Conditioned reinforcement - inactives	2.6	2.9	3.5	1.7	-1.5	1.9
Conditioned locomotion	1.4	1.7	2.7	1.6	-1.5	-0.4
Intermittent access intake day 1-15 change	0.3	0.3	0.5	0.3	-0.6	-0.7
Intermittent access intake escalation	0.3	0.3	0.7	0.3	-0.4	-0.8
Intermittent access intake escalation 2	0.7	0.7	1.6	-0.5	0.4	-1.3
Intermitt. access day 1 inactive lever presses	1.7	1.8	2.4	1.3	-1.2	1.5
Intermitt. access day 15 inactive lever presses	2.2	2.5	3.3	1.8	-1.7	1.1
Intermitt. access escalation Index	1.9	1.7	3.7	-0.7	1.0	-1.9
Intermittent access day 1 total infusions	0.3	0.3	0.5	0.3	-0.6	0.7
Intermittent access day 15 total infusions	0.3	0.3	0.7	0.6	-0.8	0.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.5	-0.8	0.1
Intermittent access total infusions	0.1	0.1	0.2	0.2	-0.5	0.2
Intermittent access day 1 locomotion	0.7	0.7	0.8	0.7	-0.8	0.9
Intermittent access day 15 total locomotion	0.5	0.5	1.1	0.6	-1.1	0.3
Intermittent access total locomotion	0.7	0.8	1.3	1.0	-1.1	0.3
Intermittent access standard deviation	0.3	0.3	0.3	0.4	-0.6	-0.6
Cocaine induced anxiety	2.2	2.6	2.9	-1.7	1.6	-1.5
Post-drug Anxiety	0.0	0.0	0.1	-0.1	0.2	0.3
Baseline Anxiety	3.5	3.7	5.0	2.2	-1.8	1.7
Lifetime Intake	0.1	0.1	0.1	0.1	-0.4	0.3
Incentive Sensitization - Responses	0.8	0.8	1.1	0.9	-1.0	0.8
Incentive Sensitization - Breakpoint	0.7	0.7	0.9	0.8	-1.0	0.6
Progressive ratio test 1 active lever presses	1.1	1.1	1.3	1.1	-1.2	0.9
Progressive ratio test 1 breakpoint	1.4	1.4	1.5	1.2	-1.2	1.1
Progressive ratio test 1 inactive lever presses	1.5	1.6	2.0	1.4	-1.3	1.0
Progressive ratio test 2 active lever presses	1.1	1.2	1.5	1.1	-1.2	1.0
Progressive ratio test 2 breakpoint	0.9	1.0	1.4	0.9	-1.2	0.9
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.0	-0.3	0.4
Total sessions with >9 infusions	0.6	0.7	1.2	0.9	-1.1	0.3
Short access day 1 total inactive lever presses	3.8	4.3	7.9	1.4	-1.7	2.8
Short access day 10 total inactive lever presses	0.2	0.2	0.3	-0.3	0.5	0.4
Short access day 1 total infusions	0.2	0.2	0.3	0.3	-0.5	0.4
Short access day 10 total infusions	0.1	0.1	0.2	-0.0	-0.5	-0.1
Short access total infusions	0.0	0.0	0.0	-0.1	-0.1	-0.1
Short access day 1 locomotion	1.6	1.6	2.3	1.5	-1.5	0.6
Short access day 10 total locomotion	1.5	1.7	2.4	1.4	-1.6	0.7
Short access total locomotion	0.6	0.6	0.9	0.9	-0.9	0.1
Compulsive drug intake	1.3	1.3	3.7	0.1	0.1	1.9
One hour access (0.3 mA shock)	0.4	0.4	0.9	0.3	-0.5	0.9
One hour access (shock baseline)	0.4	0.4	0.6	0.5	-0.7	-0.6
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.3	-0.4
Context. condit. distance diff. score	0.5	0.6	0.7	-0.9	0.6	-0.8
Locomotion velocity, session 1	1.0	1.1	1.3	-0.9	1.1	-1.1
Locomotion distance, session 1	2.5	3.2	5.5	-1.9	2.3	-0.6
Locomotion velocity, session 2	0.6	0.7	1.0	-1.0	1.0	-0.1
Locomotion distance, session 2	0.8	1.1	1.9	-1.2	1.4	0.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.1	0.4	-0.2
Locomotion distance, session 3	0.6	0.6	0.8	-0.9	0.9	0.6
Stereotopy head waving bouts, day 3	2.5	3.0	4.8	2.0	-2.2	0.2
Stereotopy head waving duration, day 3	0.6	0.7	0.9	1.0	-0.9	-0.4
Locomotion velocity, session 7	0.2	0.2	0.4	-0.5	0.6	0.2
Locomotion distance, session 7	0.6	0.7	2.2	-0.3	0.0	1.5
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	0.8	-0.9	0.1
Stereotopy head waving duration, day 7	0.1	0.1	0.1	0.3	-0.3	-0.2
Locomotion velocity, session 8	6.0	7.1	8.0	-2.8	2.8	-2.4
Locomotion distance, session 8	1.3	2.0	2.8	-1.7	1.7	-0.7
Degree of sensitization distance	0.1	0.1	0.1	-0.3	0.2	-0.2
Degree of sensitization stereotypy	1.1	1.2	1.5	1.1	-1.2	1.0
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	0.5	-0.7	0.8
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.1	0.9	-1.1	0.7
Condit. Reinf. active responses	0.5	0.6	0.8	0.7	-0.8	0.9
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.8	-0.6	0.9
Incentive salience index mean	1.3	1.6	2.1	1.2	-1.2	1.5
Condit. Reinf. lever presses	1.4	1.8	3.1	1.2	-1.0	1.8
Time in familiar zone, hab. session 1	0.9	0.8	1.3	0.6	-0.9	1.2
Time in novel zone, hab. session 1	0.6	0.6	0.9	1.0	-0.7	-0.5
Total zone transitions, hab. session 1	1.7	2.3	3.7	-1.7	1.9	0.6
Total locomotion distance, hab. session 1	0.4	0.6	1.7	-0.0	0.1	1.3
Locomotion velocity, hab. session 1	0.5	0.7	0.8	-0.7	0.9	0.9
Time in familiar zone, hab. session 2	0.5	0.5	0.7	0.8	-0.9	0.4
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	-0.1	0.1
Total zone transitions, hab. session 2	0.4	0.5	0.7	-0.8	0.9	0.5
Total locomotion distance, hab. session 2	0.0	0.0	0.0	-0.0	0.2	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.3	0.4	-0.1
Novel to familiar place preference ratio	1.4	1.4	2.4	-1.6	1.3	-0.6
Novelty place preference	0.8	0.8	1.6	-1.3	0.9	-0.3
Time in novel zone, NPP test	0.2	0.3	0.6	-0.7	0.4	0.1
Total zone transitions, NPP test	0.4	0.6	1.0	-0.5	0.8	1.0
Total locomotion distance, NPP test	0.2	0.2	0.7	0.2	0.0	0.8
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.4	0.7	0.5
Pavlov. Cond. lever latency	3.7	4.7	6.4	-2.0	1.9	-2.5
Pavlov. Cond. magazine entry latency	8.4	10.9	13.3	3.4	-3.6	2.8
Pavlov. Cond. change in total contacts	7.2	7.6	9.6	2.4	-2.7	3.1
Pavlov. Cond. index score	7.9	10.1	10.8	3.2	-3.3	3.1
Pavlov. Cond. latency score	6.2	8.0	8.1	2.8	-2.8	2.8
Pavlov. Cond. lever contacts	3.3	3.9	5.7	1.8	-1.7	2.4
Pavlov. Cond. magazine entry number	10.6	13.3	15.3	-3.7	3.9	-3.3
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.1	-1.3	1.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	8.8	11.1	12.1	3.3	-3.5	3.2
Pavlov. Cond. response bias	8.8	10.8	11.7	3.3	-3.4	3.2
Bone: apparent density	1.0	1.7	2.6	1.6	-1.6	0.2
Bone surface	0.1	0.3	0.6	-0.3	0.3	-0.7
Bone volume	0.2	0.3	0.8	0.1	-0.0	-0.9
Bone: connectivity density	1.9	3.0	3.8	1.9	-1.9	1.3
Bone: cortical apparent density	6.6	8.6	15.1	2.2	-2.4	3.9
Bone: cortical area	0.0	0.1	0.1	0.3	-0.3	0.2
Bone: cortical porosity	0.6	0.7	1.2	1.1	-0.9	0.3
Bone: cortical porosity	1.0	1.1	1.7	1.3	-1.1	0.5
Bone: cortical thickness	0.9	1.5	1.9	1.1	-1.2	1.4
Bone: cortical thickness	5.0	5.8	6.8	2.2	-2.4	2.6
Bone: cortical tissue density	6.7	8.7	15.5	2.2	-2.4	3.9
Bone: elastic displacement	0.0	0.0	0.1	0.3	-0.1	-0.1
Bone: elastic work	0.0	0.0	0.0	-0.1	0.2	-0.1
Bone: endosteal estimation	1.8	3.9	4.3	-1.9	1.9	-2.1
Bone: endosteal perimeter	1.7	3.4	4.2	-1.7	1.8	-2.0
Bone: final force	0.8	1.2	1.8	1.2	-1.3	0.7
Bone: final moment	0.6	1.0	1.4	1.2	-1.2	0.5
Bone: marrow area	1.7	3.6	3.7	-1.9	1.9	-1.9
Bone: maximum diameter	0.1	0.1	0.3	0.0	0.0	-0.6
Bone: maximum force	0.0	0.1	0.2	0.0	-0.2	-0.5
Bone: maximum moment	0.1	0.1	0.3	-0.0	-0.1	-0.6
Bone: minimum diameter	0.5	0.9	1.1	-1.1	0.9	-0.9
Bone: periosteal estimation	0.3	0.6	1.0	-0.6	0.6	-1.0
Bone: periosteal perimeter	0.7	1.2	1.5	-1.0	1.0	-1.2
Bone: post-yield work	0.9	1.2	1.4	-1.2	1.1	-1.0
Bone: stiffness	0.0	0.0	0.1	0.1	-0.2	-0.0
Bone: tissue strength	0.6	0.6	0.7	-0.8	0.8	-0.7
Bone: trabecular number	3.3	5.1	6.8	2.6	-2.6	1.4
Bone: trabecular spacing	0.5	0.6	0.9	-0.8	0.9	-0.6
Bone: trabecular thickness	0.2	0.3	0.8	-0.0	0.1	-0.9
Bone: trabecular tissue density	0.1	0.1	0.2	0.2	-0.1	0.4
Breakpoint value in progressive ratio session	0.9	1.0	1.1	-1.0	1.0	1.0
Distance traveled before self-admin	0.1	0.1	0.4	0.1	0.0	0.6
Distance traveled after self-admin	1.6	1.8	2.8	-1.1	1.1	-1.7
Delta time in closed arm before/after self-admin	2.7	2.6	3.3	-1.8	1.8	-1.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.3	-0.1	0.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	-0.2	0.0	0.8
Extinction: sum of active levers before priming	0.6	0.6	1.5	-1.2	0.7	0.0
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.5	0.3
Delta distance traveled before/after self-admin	2.3	2.4	4.8	-1.2	1.1	-2.2
Delta ambulatory time before/after self-admin	1.3	1.4	3.5	-0.6	0.6	-1.9
Time in closed arm before self-admin	1.3	1.5	3.2	1.8	-1.1	0.1
Time in closed arm after self-admin	0.7	0.8	1.4	-0.4	0.9	-1.2
Time in open arm before self-admin	2.5	2.7	3.7	-1.9	1.7	-1.3
Time in open arm after self-admin	0.3	0.3	0.5	-0.7	0.6	-0.1
Sum of active levers in priming session hrs 5-6	1.5	1.5	3.8	-0.0	-0.8	2.0
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.8	-0.0	-0.5	1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.3	-0.2	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	0.8	-0.9	0.7	-0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.5	0.0	-0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.6	-0.5	-0.4
Delta time to tail flick, test, before/after SA	1.1	1.0	1.1	0.9	-1.0	1.0
Ambulatory time before self-admin	0.1	0.1	0.1	-0.2	0.4	0.2
Ambulatory time after self-admin	3.6	3.9	5.7	-1.8	1.7	-2.4
Total heroin consumption	0.6	0.7	1.9	0.0	-0.5	1.4
Area under the delay curve	0.9	0.9	1.0	0.9	-1.0	1.0
Delay disc. indifference point, 0s delay	1.5	1.6	2.3	1.2	-1.1	1.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	0.6	-0.8	0.1
Delay disc. indifference point, 2s delay	2.3	2.5	3.0	1.7	-1.6	1.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.4	-0.1	0.2
Delay disc. indifference point, 4s delay	1.1	1.2	2.8	0.6	-0.6	1.7
Delay disc. indifference point, 8s delay	1.0	1.1	1.1	1.0	-1.1	1.1
Delay discount exponential model param	0.4	0.5	0.6	-0.6	0.7	-0.8
Delay discount hyperbolic model param	0.8	0.8	1.1	-0.8	0.9	-1.0
Fecal boli incidents, locomotor time 1	1.1	1.1	2.7	-0.6	0.7	-1.6
Change in fecal boli incidents, locomotor task	0.7	0.7	1.8	0.2	-0.5	1.3
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.3	1.0	-1.0	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.3	0.5	-0.3
Total resting periods, locomotor time 1	0.3	0.3	0.3	-0.4	0.6	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.2	0.5	0.1	-0.0
Distance moved, locomotor task time 1	0.6	0.6	1.4	0.2	-0.7	1.2
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.3	-0.2	0.3
Time >=10cm from walls, locomotor time 2	2.3	2.5	3.0	1.4	-1.5	1.7
Bouts of movement, locomotor time 2	0.2	0.2	0.3	0.5	-0.6	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.4	0.2
Rest time, locomotor task time 2	0.4	0.5	1.0	-0.7	1.0	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.2	0.0	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	-0.3
Weight adjusted by age	0.2	0.2	0.4	-0.6	0.5	0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.2	0.1	-0.7
Locomotion in novel chamber	2.6	3.2	4.4	1.4	-1.8	2.1
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	1.0	-0.6	-0.4
Progressive ratio	0.2	0.2	0.4	0.4	0.0	0.6
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.5	-0.6	0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.1	-0.5	-0.0
Run reversals in cocaine runway, females	1.6	1.5	2.5	-1.6	1.2	-0.8
Run reversals in cocaine runway, males	0.4	0.4	0.7	0.9	-0.7	0.1
Latency to leave start box in cocaine runway	3.5	3.9	6.0	-1.5	1.8	-2.4
Latency to leave start box in cocaine runway, F	3.7	4.0	7.4	-1.2	1.8	-2.7
Latency to leave start box in cocaine runway, M	0.6	0.6	0.9	-1.0	0.6	-0.8
Cd content in liver	0.5	0.5	1.2	0.4	-0.5	1.1
Co content in liver	1.3	1.5	1.8	-1.3	1.3	-1.0
Cu content in liver	0.6	0.7	1.3	-1.0	1.1	0.1
Fe content in liver	1.1	1.3	1.9	-1.3	1.4	-0.2
K content in liver	0.1	0.1	0.1	0.3	-0.3	-0.0
Mg content in liver	0.3	0.3	0.6	0.4	-0.3	0.8
Mn content in liver	0.9	1.1	2.5	0.5	-0.6	1.6
Na content in liver	0.2	0.2	0.3	0.6	-0.3	-0.3
Rb content in liver	1.3	1.6	2.2	1.5	-1.2	1.0
Se content in liver	1.4	1.7	2.3	1.4	-1.5	0.9
Sr content in liver	0.3	0.2	0.3	-0.5	0.4	0.5
Zn content in liver	1.9	2.1	2.9	1.7	-1.4	1.1