Hub : Genes

Stac2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000004805	0.07	0.05	4.6e-08	0.07	0.08	0.08	0.08	2.1e-07	6.2e-08	1.3e-07	1.1e-07
2	IL	gene expression	ENSRNOG00000004805	0.16	0.14	4.6e-03	0.12	0.09	0.11	0.09	6.9e-04	3.2e-03	1.1e-03	3.4e-03
3	OFC	gene expression	ENSRNOG00000004805	0.23	0.2	2.2e-03	0.08	-0.01	0	-0	6.2e-03	4.9e-01	2.7e-01	3.8e-01
4	PL	alternative TSS	ENSRNOT00000066855	0.04	0.03	5.1e-03	0.02	0.03	0.01	0.02	8.0e-03	3.1e-03	8.0e-02	2.1e-02
5	PL	alternative TSS	ENSRNOT00000091978	0.04	0.03	4.9e-03	0.02	0.03	0.01	0.02	8.1e-03	3.1e-03	7.0e-02	1.7e-02
6	PL	gene expression	ENSRNOG00000004805	0.15	0.08	4.7e-12	0.12	0.13	0.12	0.12	1.8e-09	8.5e-10	2.0e-09	2.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	1.6	5.3	5.9	-2.4	-2.1	-2.1	2.4	-2.4	-2.4
BMI without tail	0.1	0.2	0.3	-0.4	-0.6	-0.6	0.4	-0.4	-0.4
Body weight	6.1	25.7	27.2	-5.2	-4.7	-4.9	5.2	-5.2	-5.2
Epididymis fat weight	0.3	0.6	0.8	-0.9	-0.5	-0.8	0.9	-0.9	-0.9
Glucose	0.6	0.9	1.0	1.0	0.9	0.9	-1.0	1.0	1.0
Heart weight	3.2	4.5	5.3	-2.2	-1.7	-2.1	2.2	-2.2	-2.3
Left kidney weight	2.3	6.7	7.6	-2.5	-2.6	-2.8	2.6	-2.6	-2.5
Right kidney weight	0.5	1.4	1.8	-1.1	-1.2	-1.3	1.2	-1.2	-1.1
Tail length	1.0	3.1	4.3	-1.6	-1.9	-2.1	1.7	-1.7	-1.6
Length with tail	4.8	17.7	18.3	-4.2	-4.1	-4.3	4.2	-4.2	-4.2
Length without tail	4.7	10.4	11.3	-3.3	-3.0	-3.0	3.3	-3.3	-3.4
Liver weight, left	0.1	0.1	0.4	-0.3	-0.3	-0.6	0.3	-0.3	-0.3
Liver weight, right	0.0	0.1	0.1	0.3	0.2	0.2	-0.2	0.2	0.3
Parametrial fat weight	0.6	1.3	2.1	1.1	1.4	1.2	-1.0	1.0	1.0
Retroperitoneal fat weight	0.1	0.2	0.3	-0.5	-0.3	-0.3	0.6	-0.6	-0.5
Intraocular pressure	1.3	1.9	2.5	-1.5	-1.0	-1.2	1.4	-1.4	-1.6
Extensor digitorum longus weight	8.5	34.1	35.5	-5.9	-5.8	-5.6	5.9	-5.9	-6.0
Soleus weight	0.4	1.2	1.4	1.0	1.0	1.2	-1.1	1.1	1.0
Tibialis anterior weight	1.4	4.7	5.0	-2.2	-2.2	-2.1	2.1	-2.1	-2.2
Tibia length	0.8	2.3	2.6	-1.6	-1.5	-1.3	1.5	-1.5	-1.6
Number of licking bursts	0.5	0.6	0.7	0.8	0.7	0.8	-0.8	0.8	0.8
Food consumed during 24 hour testing period	1.0	1.2	1.7	-1.1	-1.3	-1.1	1.1	-1.1	-1.0
Times rat made contact with spout	1.0	1.2	1.4	1.1	0.7	1.1	-1.1	1.1	1.2
Mean time between licks in bursts	1.5	2.1	2.4	-1.4	-1.4	-1.5	1.4	-1.4	-1.4
Mean num. licks in bursts	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	0.1
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.5	-0.7	-0.3	0.5	-0.5	-0.4
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0	-0.0	-0.1
Indifference point 0 sec	1.5	2.5	2.7	1.6	1.5	1.6	-1.5	1.5	1.6
Indifference point AUC	0.1	0.1	0.3	-0.1	-0.5	-0.4	0.1	-0.1	0.0
Indifference point function ln k	0.0	0.0	0.1	0.0	0.2	0.3	-0.0	0.0	-0.0
Indifference point function log k	0.0	0.0	0.1	0.0	0.2	0.3	-0.0	0.0	-0.0
Delay discounting total patch changes 0 sec	1.0	1.6	1.8	1.3	1.2	1.3	-1.3	1.3	1.3
Delay discounting total patch changes 12 sec	4.7	6.3	7.2	2.6	2.3	2.4	-2.5	2.5	2.7
Delay discounting total patch changes 18 sec	0.4	0.6	0.9	0.9	0.5	0.4	-0.8	0.8	0.9
Delay discounting total patch changes 24 sec	1.9	2.4	3.1	1.7	1.3	1.1	-1.7	1.7	1.8
Delay discounting total patch changes 6 sec	1.5	2.3	3.0	1.6	1.2	1.3	-1.6	1.6	1.7
Delay discounting time to switch 0 sec	0.0	0.1	0.1	0.3	0.3	0.2	-0.2	0.2	0.2
Delay discounting water rate 0 sec	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1	-0.1
Delay discounting water rate 12 sec	0.3	0.5	0.6	-0.7	-0.8	-0.7	0.6	-0.6	-0.7
Delay discounting water rate 18 sec	0.5	0.6	1.0	0.8	1.0	0.7	-0.8	0.8	0.7
Delay discounting water rate 24 sec	0.3	0.4	0.8	0.6	0.9	0.6	-0.6	0.6	0.6
Delay discounting water rate 6 sec	0.9	1.3	1.4	1.2	1.2	1.0	-1.1	1.1	1.2
Locomotor activity	0.6	0.9	1.0	1.0	0.9	1.0	-1.0	1.0	1.0
Locomotor testing distance	3.1	5.2	6.4	2.2	2.5	2.3	-2.2	2.2	2.1
Locomotor testing rearing	5.8	9.2	9.4	3.0	3.1	3.0	-3.0	3.0	3.0
Light reinforcement 1	2.1	3.9	4.4	2.0	2.1	2.0	-1.9	1.9	2.0
Light reinforcement 2	0.8	1.0	1.1	1.0	1.0	1.0	-1.0	1.0	1.0
Reaction time number correct	0.8	1.1	1.3	-1.1	-1.1	-1.2	1.0	-1.0	-1.1
Reaction time mean minus median	0.1	0.1	0.1	-0.3	-0.2	-0.0	0.3	-0.3	-0.4
Reaction time mean minus median AUC	0.2	0.3	0.5	0.5	0.7	0.7	-0.5	0.5	0.4
Reaction time num false alarms	0.8	1.1	1.4	1.0	1.2	1.0	-1.0	1.0	1.0
Reaction time num false alarms AUC	0.6	0.8	1.1	0.9	1.0	0.9	-0.9	0.9	0.9
Reaction time trials correct on left	0.8	1.1	1.3	-1.1	-1.1	-1.2	1.0	-1.0	-1.1
Reaction time trials on left	0.8	1.1	1.3	-1.0	-1.1	-1.1	1.0	-1.0	-1.0
Reaction time mean	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0	0.0	0.0
Median of all reaction times	0.3	0.3	0.5	0.7	0.3	0.5	-0.6	0.6	0.7
Reaction time omissions	0.7	1.0	1.2	1.0	0.8	1.0	-1.0	1.0	1.1
Reaction time false alarm rate	1.3	1.8	2.2	1.3	1.5	1.4	-1.3	1.3	1.3
Reaction time premature initiation rate	0.3	0.5	0.8	0.6	0.9	0.8	-0.6	0.6	0.5
Reaction time premature initiations	0.0	0.0	0.1	-0.2	0.0	-0.1	0.2	-0.2	-0.3
Std. dev. reaction times	0.0	0.0	0.1	0.1	0.1	0.3	-0.1	0.1	0.0
Reaction time trials completed	0.8	1.1	1.3	-1.0	-1.1	-1.1	1.0	-1.0	-1.0
Reaction time trials AUC	0.6	0.9	1.1	-0.9	-1.0	-1.0	0.9	-0.9	-0.9
Social response proportion	0.0	0.0	0.0	-0.0	0.1	0.1	-0.0	0.0	-0.1
Social responses	0.1	0.1	0.2	0.3	0.3	0.4	-0.3	0.3	0.3
Social time	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1	-0.1	-0.1
Conditioned locomotion	0.1	0.2	0.4	0.3	0.4	0.6	-0.3	0.3	0.3
Cocaine response after cond. corrected	2.3	2.6	3.0	1.7	1.3	1.5	-1.7	1.7	1.7
Cocaine response after cond. not corrected	3.8	4.2	4.5	2.1	1.8	2.1	-2.1	2.1	2.1
Cocaine response before conditioning	1.0	1.3	2.0	1.0	1.3	1.4	-1.0	1.0	0.9
Saline control response	0.3	0.4	1.0	0.5	0.8	1.0	-0.6	0.6	0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.8	0.8	1.0	-0.8	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	0.6	0.3	0.4	-0.5	0.5	0.6
Condit. Reinf. active responses	1.1	1.6	2.3	1.2	1.2	1.5	-1.2	1.2	1.2
Condit. Reinf. inactive responses	2.5	3.1	4.0	1.7	1.9	2.0	-1.7	1.7	1.6
Condit. Reinf. lever presses	0.1	0.1	0.3	0.2	0.2	0.6	-0.2	0.2	0.2
Condit. Reinf. lever reinforcers received	1.1	1.5	2.2	1.2	1.2	1.5	-1.2	1.2	1.2
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.5	-0.4	-0.8	0.5	-0.5	-0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.5	0.7	0.8	0.8	0.7	0.9	-0.8	0.8	0.9
Pavlov. Cond. index score	0.2	0.3	0.6	0.5	0.3	0.8	-0.5	0.5	0.5
Pavlov. Cond. latency score	0.1	0.2	0.5	0.4	0.2	0.7	-0.4	0.4	0.4
Pavlov. Cond. lever contacts	0.8	1.2	1.8	1.0	0.9	1.3	-1.1	1.1	1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.3	-0.2	-0.6	0.3	-0.3	-0.3
Pavlov. Cond. intertrial magazine entries	1.7	2.1	2.3	-1.5	-1.3	-1.5	1.5	-1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.3	0.1	0.6	-0.3	0.3	0.4
Pavlov. Cond. response bias	1.0	1.4	1.9	1.2	0.9	1.4	-1.2	1.2	1.2
Conditioned reinforcement - actives	1.5	1.5	2.1	1.1	1.5	1.4	-1.1	1.1	1.1
Conditioned reinforcement - inactives	1.3	1.5	2.0	1.2	1.4	1.2	-1.2	1.2	1.1
Conditioned locomotion	1.2	1.4	1.9	1.1	1.4	1.2	-1.2	1.2	1.1
Intermittent access intake day 1-15 change	0.2	0.2	0.3	0.3	0.5	0.5	-0.3	0.3	0.3
Intermittent access intake escalation	0.1	0.1	0.1	0.2	0.3	0.3	-0.2	0.2	0.2
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3	-0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.9	0.9	1.4	0.9	1.2	1.0	-0.9	0.9	0.9
Intermitt. access day 15 inactive lever presses	2.9	3.2	3.7	1.9	1.6	1.5	-1.9	1.9	1.8
Intermitt. access escalation Index	0.9	0.8	0.9	-1.0	-0.9	-0.6	0.9	-0.9	-1.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	0.5	0.4	-0.4	0.4	0.4
Intermittent access day 15 total infusions	0.3	0.3	0.4	0.5	0.7	0.6	-0.5	0.5	0.5
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.6	0.6	0.7	0.6	-0.6	0.6	0.6
Intermittent access total infusions	0.0	0.0	0.1	0.1	0.3	0.2	-0.1	0.1	0.1
Intermittent access day 1 locomotion	0.4	0.4	0.5	0.6	0.7	0.7	-0.6	0.6	0.6
Intermittent access day 15 total locomotion	0.6	0.6	0.8	0.8	0.9	0.9	-0.8	0.8	0.7
Intermittent access total locomotion	0.7	0.8	1.1	0.9	1.0	0.9	-0.9	0.9	0.8
Intermittent access standard deviation	0.2	0.2	0.3	0.5	0.5	0.4	-0.5	0.5	0.5
Cocaine induced anxiety	2.2	2.6	2.6	-1.6	-1.6	-1.6	1.6	-1.6	-1.6
Post-drug Anxiety	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	-0.2	-0.2
Baseline Anxiety	3.2	3.4	3.5	1.8	1.9	1.9	-1.9	1.9	1.8
Lifetime Intake	0.0	0.0	0.1	0.1	0.3	0.2	-0.1	0.1	0.1
Incentive Sensitization - Responses	1.1	1.1	1.2	1.1	0.9	0.9	-1.1	1.1	1.1
Incentive Sensitization - Breakpoint	1.1	1.1	1.2	1.1	0.9	0.9	-1.1	1.1	1.1
Progressive ratio test 1 active lever presses	1.3	1.3	1.4	1.2	1.1	1.1	-1.2	1.2	1.2
Progressive ratio test 1 breakpoint	1.2	1.3	1.3	1.1	1.1	1.1	-1.1	1.1	1.1
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.3	1.0	1.1	1.1	-1.0	1.0	1.0
Progressive ratio test 2 active lever presses	1.1	1.2	1.3	1.1	1.1	1.0	-1.1	1.1	1.1
Progressive ratio test 2 breakpoint	1.0	1.1	1.2	1.1	1.1	1.0	-1.1	1.1	1.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	0.1	-0.0	-0.3	0.3	0.3
Total sessions with >9 infusions	0.9	0.9	1.2	0.9	1.0	1.1	-0.9	0.9	1.0
Short access day 1 total inactive lever presses	1.6	1.8	2.5	1.3	1.6	1.2	-1.3	1.3	1.3
Short access day 10 total inactive lever presses	0.5	0.6	0.7	-0.8	-0.6	-0.7	0.8	-0.8	-0.8
Short access day 1 total infusions	0.2	0.2	0.4	0.4	0.6	0.4	-0.4	0.4	0.4
Short access day 10 total infusions	0.2	0.2	0.2	0.5	0.5	0.4	-0.5	0.5	0.5
Short access total infusions	0.0	0.0	0.0	0.1	0.2	0.1	-0.0	0.0	0.1
Short access day 1 locomotion	2.6	2.7	3.1	1.7	1.5	1.5	-1.7	1.7	1.8
Short access day 10 total locomotion	2.2	2.4	3.1	1.5	1.6	1.8	-1.5	1.5	1.4
Short access total locomotion	0.5	0.5	0.8	0.6	0.9	0.9	-0.6	0.6	0.6
Compulsive drug intake	0.1	0.1	0.1	-0.3	-0.1	-0.1	0.3	-0.3	-0.2
One hour access (0.3 mA shock)	0.0	0.1	0.2	0.1	0.4	0.3	-0.1	0.1	0.0
One hour access (shock baseline)	0.2	0.2	0.4	0.4	0.7	0.5	-0.4	0.4	0.3
Number of responses in last shaping day	0.0	0.0	0.1	0.0	-0.3	-0.2	0.0	-0.0	0.1
Context. condit. distance diff. score	0.5	0.6	0.7	-0.8	-0.6	-0.6	0.8	-0.8	-0.9
Locomotion velocity, session 1	0.8	0.9	1.1	-0.9	-1.1	-1.0	0.9	-0.9	-0.8
Locomotion distance, session 1	3.8	4.9	5.2	-2.2	-2.3	-2.2	2.3	-2.3	-2.2
Locomotion velocity, session 2	0.7	0.8	1.1	-0.8	-1.0	-1.1	0.9	-0.9	-0.8
Locomotion distance, session 2	0.9	1.3	1.9	-1.1	-1.4	-1.2	1.2	-1.2	-1.0
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.4	-0.4	-0.4
Locomotion distance, session 3	0.5	0.6	0.7	-0.7	-0.9	-0.7	0.8	-0.8	-0.7
Stereotopy head waving bouts, day 3	3.7	4.5	4.8	2.1	2.2	2.2	-2.1	2.1	2.1
Stereotopy head waving duration, day 3	0.5	0.7	0.9	0.7	0.9	0.9	-0.8	0.8	0.7
Locomotion velocity, session 7	0.7	0.8	1.0	-1.0	-0.7	-0.6	0.9	-0.9	-1.0
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.4	-0.4	-0.4
Stereotopy head waving bouts, day 7	1.0	1.1	1.3	1.0	0.9	1.2	-1.0	1.1	1.1
Stereotopy head waving duration, day 7	0.2	0.3	0.3	0.6	0.4	0.5	-0.5	0.5	0.6
Locomotion velocity, session 8	7.2	8.6	9.3	-3.0	-2.8	-2.7	3.0	-3.0	-3.0
Locomotion distance, session 8	1.6	2.4	2.7	-1.6	-1.6	-1.5	1.6	-1.6	-1.5
Degree of sensitization distance	0.3	0.3	0.4	-0.6	-0.3	-0.6	0.5	-0.5	-0.6
Degree of sensitization stereotypy	1.7	1.8	2.1	1.4	1.2	1.4	-1.4	1.4	1.3
Condit. Reinf. active minus inactive responses	0.5	0.5	0.6	0.7	0.7	0.8	-0.7	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.1	0.9	1.1	1.0	-0.9	0.9	0.8
Condit. Reinf. active responses	0.7	0.9	1.0	1.0	0.8	0.9	-0.9	0.9	1.0
Condit. Reinf. inactive responses	0.5	0.6	0.7	0.8	0.7	0.7	-0.8	0.8	0.8
Incentive salience index mean	1.5	1.8	1.9	1.4	1.3	1.3	-1.3	1.3	1.4
Condit. Reinf. lever presses	1.1	1.4	1.6	1.3	1.1	1.1	-1.2	1.2	1.3
Time in familiar zone, hab. session 1	0.6	0.6	0.8	0.7	0.9	0.9	-0.7	0.7	0.7
Time in novel zone, hab. session 1	0.6	0.6	0.7	0.8	0.8	0.7	-0.8	0.8	0.8
Total zone transitions, hab. session 1	2.4	3.4	3.8	-1.8	-1.9	-1.8	1.8	-1.8	-1.8
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	0.0	0.2	-0.2	-0.2
Locomotion velocity, hab. session 1	0.6	0.8	0.9	-1.0	-0.9	-0.7	1.0	-1.0	-0.9
Time in familiar zone, hab. session 2	0.5	0.6	0.7	0.7	0.8	0.9	-0.7	0.7	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.2	0.1	-0.2	0.2	0.2
Total zone transitions, hab. session 2	0.7	0.9	0.9	-0.9	-0.9	-0.9	0.9	-0.9	-0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.4	-0.4	-0.4
Locomotion velocity, hab. session 2	0.3	0.3	0.5	-0.7	-0.4	-0.3	0.6	-0.6	-0.7
Novel to familiar place preference ratio	1.4	1.5	1.6	-1.2	-1.3	-1.2	1.2	-1.2	-1.2
Novelty place preference	0.9	0.9	0.9	-1.0	-0.9	-0.9	0.9	-0.9	-1.0
Time in novel zone, NPP test	0.2	0.2	0.2	-0.5	-0.5	-0.4	0.4	-0.4	-0.5
Total zone transitions, NPP test	0.3	0.5	0.5	-0.7	-0.7	-0.6	0.7	-0.7	-0.7
Total locomotion distance, NPP test	0.0	0.0	0.1	0.1	0.0	0.3	-0.0	0.0	0.1
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.6	-0.6	-0.3	0.6	-0.6	-0.6
Pavlov. Cond. lever latency	3.1	3.9	4.1	-2.0	-1.9	-2.0	2.0	-2.0	-2.0
Pavlov. Cond. magazine entry latency	11.0	14.3	14.6	3.8	3.7	3.8	-3.8	3.8	3.8
Pavlov. Cond. change in total contacts	8.7	9.3	9.8	3.1	2.8	3.0	-3.1	3.1	3.1
Pavlov. Cond. index score	9.2	11.8	12.1	3.5	3.3	3.5	-3.5	3.4	3.5
Pavlov. Cond. latency score	7.2	9.3	9.5	3.1	2.9	3.1	-3.1	3.1	3.1
Pavlov. Cond. lever contacts	2.8	3.3	3.4	1.8	1.7	1.8	-1.8	1.8	1.8
Pavlov. Cond. magazine entry number	13.8	17.2	17.9	-4.2	-3.9	-4.2	4.2	-4.2	-4.2
Pavlov. Cond. intertrial magazine entries	1.7	2.1	2.6	-1.4	-1.4	-1.6	1.4	-1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	10.5	13.1	13.4	3.7	3.5	3.6	-3.6	3.6	3.6
Pavlov. Cond. response bias	10.3	12.7	13.0	3.6	3.4	3.6	-3.6	3.6	3.6
Bone: apparent density	2.2	3.6	4.2	2.0	1.7	1.7	-2.0	2.0	2.0
Bone surface	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.1	-0.1	0.1
Bone volume	0.1	0.1	0.2	0.4	0.1	0.2	-0.4	0.4	0.5
Bone: connectivity density	2.9	4.6	5.0	2.2	2.0	2.1	-2.2	2.2	2.2
Bone: cortical apparent density	6.1	7.9	8.8	2.9	2.6	2.7	-2.9	2.9	3.0
Bone: cortical area	0.2	0.3	0.3	0.5	0.4	0.5	-0.6	0.6	0.5
Bone: cortical porosity	0.7	0.8	0.9	0.8	0.9	0.9	-0.9	0.9	0.8
Bone: cortical porosity	0.9	0.9	1.3	0.9	1.1	1.0	-1.0	1.0	0.8
Bone: cortical thickness	1.6	2.6	2.9	1.7	1.3	1.5	-1.7	1.7	1.7
Bone: cortical thickness	5.4	6.4	6.5	2.6	2.5	2.5	-2.5	2.5	2.5
Bone: cortical tissue density	6.1	7.9	8.8	2.9	2.6	2.7	-2.9	2.9	3.0
Bone: elastic displacement	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.1
Bone: elastic work	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.0	0.1
Bone: endosteal estimation	2.2	4.7	5.1	-2.2	-2.0	-2.1	2.2	-2.2	-2.2
Bone: endosteal perimeter	1.9	3.9	4.0	-2.0	-1.9	-1.9	2.0	-2.0	-2.0
Bone: final force	1.2	2.0	2.1	1.4	1.4	1.5	-1.4	1.4	1.4
Bone: final moment	1.0	1.6	1.7	1.3	1.3	1.3	-1.3	1.3	1.2
Bone: marrow area	2.1	4.4	4.8	-2.2	-1.9	-2.0	2.2	-2.2	-2.2
Bone: maximum diameter	0.0	0.0	0.0	0.1	-0.0	0.1	-0.1	0.1	0.2
Bone: maximum force	0.0	0.1	0.1	0.2	0.3	0.4	-0.3	0.3	0.2
Bone: maximum moment	0.0	0.0	0.1	0.1	0.1	0.2	-0.1	0.1	0.1
Bone: minimum diameter	0.4	0.8	0.9	-0.9	-0.9	-0.7	0.9	-0.9	-0.9
Bone: periosteal estimation	0.2	0.4	0.4	-0.6	-0.6	-0.6	0.6	-0.6	-0.6
Bone: periosteal perimeter	0.7	1.1	1.2	-1.1	-1.0	-1.0	1.1	-1.1	-1.1
Bone: post-yield work	1.0	1.3	1.7	-1.2	-0.9	-1.0	1.2	-1.2	-1.3
Bone: stiffness	0.1	0.1	0.1	0.3	0.3	0.4	-0.3	0.3	0.3
Bone: tissue strength	0.4	0.4	0.5	-0.6	-0.7	-0.5	0.6	-0.6	-0.6
Bone: trabecular number	5.2	8.1	8.8	2.9	2.7	2.7	-2.9	2.9	3.0
Bone: trabecular spacing	0.9	1.1	1.4	-1.1	-0.8	-0.9	1.1	-1.1	-1.2
Bone: trabecular thickness	0.0	0.0	0.1	0.2	-0.0	-0.0	-0.2	0.2	0.3
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	0.1	0.1
Breakpoint value in progressive ratio session	1.1	1.2	1.6	-1.1	-0.9	-1.2	1.1	-1.1	-1.1
Distance traveled before self-admin	0.2	0.2	0.3	-0.5	-0.1	-0.4	0.4	-0.4	-0.6
Distance traveled after self-admin	1.7	1.9	2.2	-1.5	-1.0	-1.2	1.5	-1.5	-1.5
Delta time in closed arm before/after self-admin	3.7	3.6	4.2	-2.0	-1.8	-1.6	2.0	-2.0	-2.0
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.2	0.2	-0.1	-0.2	0.2	0.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	-0.7	0.2	-0.4	0.6	-0.6	-0.8
Extinction: sum of active levers before priming	0.8	0.8	1.2	-1.0	-0.5	-0.8	1.0	-1.0	-1.1
Active lever presses in extinction session 6	0.4	0.4	0.5	0.6	0.7	0.6	-0.6	0.6	0.6
Delta distance traveled before/after self-admin	1.1	1.2	1.4	-1.2	-0.9	-1.0	1.2	-1.2	-1.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	-0.7	-0.4	-0.3	0.7	-0.7	-0.7
Time in closed arm before self-admin	1.2	1.4	1.6	1.2	1.3	1.1	-1.2	1.2	1.2
Time in closed arm after self-admin	0.6	0.6	0.7	-0.8	-0.8	-0.6	0.8	-0.8	-0.8
Time in open arm before self-admin	3.2	3.5	3.7	-1.9	-1.9	-1.7	1.9	-1.9	-1.9
Time in open arm after self-admin	0.6	0.7	0.9	-0.8	-0.7	-0.9	0.8	-0.8	-0.9
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.7	0.6	0.8	0.6	-0.6	0.6	0.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.4	0.5	0.6	-0.4	0.4	0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.4	0.1	0.4	-0.4	0.4	0.4
Time to tail flick, test, before self-admin	0.8	0.8	1.1	-1.0	-0.6	-0.7	0.9	-0.9	-1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.0	0.1	-0.3	0.3	0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.3	0.6	0.4	0.4	-0.6	0.6	0.6
Delta time to tail flick, test, before/after SA	2.2	2.0	2.6	1.6	1.0	1.1	-1.5	1.5	1.6
Ambulatory time before self-admin	0.5	0.5	0.9	-0.7	-0.5	-0.9	0.7	-0.7	-0.8
Ambulatory time after self-admin	3.1	3.4	3.8	-1.9	-1.6	-1.8	1.9	-1.9	-1.9
Total heroin consumption	0.3	0.4	0.6	0.7	0.5	0.2	-0.7	0.7	0.8
Area under the delay curve	0.8	0.8	1.3	0.9	1.1	0.8	-0.9	0.9	0.9
Delay disc. indifference point, 0s delay	1.3	1.4	1.7	1.2	1.3	0.9	-1.2	1.2	1.2
Delay disc. indifference point, 16s delay	0.8	0.8	0.8	0.9	0.9	0.8	-0.9	0.9	0.9
Delay disc. indifference point, 2s delay	2.4	2.7	2.9	1.6	1.7	1.5	-1.7	1.7	1.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.3	0.3
Delay disc. indifference point, 4s delay	0.6	0.6	0.8	0.9	0.7	0.3	-0.9	0.9	0.9
Delay disc. indifference point, 8s delay	0.6	0.6	1.3	0.7	1.2	0.6	-0.7	0.7	0.6
Delay discount exponential model param	0.4	0.4	0.7	-0.6	-0.8	-0.5	0.7	-0.7	-0.6
Delay discount hyperbolic model param	0.6	0.7	1.0	-0.8	-1.0	-0.6	0.8	-0.8	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.3	0.4	-0.4	-0.6	-0.6	0.4	-0.4	-0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.3	0.7	0.6	-0.3	0.3	0.2
Time >=10cm from walls, locomotor time 1	0.8	0.8	0.9	0.9	0.9	0.8	-0.9	0.9	0.9
Bouts of movement, locomotor time 1	0.6	0.6	1.0	-0.8	-0.3	-1.0	0.8	-0.8	-0.9
Total resting periods, locomotor time 1	0.8	0.9	1.2	-1.0	-0.5	-1.1	1.0	-1.0	-1.1
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.0	0.1	-0.3	0.0	-0.0	-0.0
Distance moved, locomotor task time 1	0.3	0.3	0.6	0.5	0.4	0.8	-0.5	0.5	0.6
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1	-0.1	-0.2
Time >=10cm from walls, locomotor time 2	2.0	2.1	2.4	1.5	1.5	1.1	-1.5	1.5	1.5
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.2	0.5	-0.0	-0.2	0.2	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	0.3	-0.2	0.0	-0.0	-0.2
Rest time, locomotor task time 2	1.3	1.5	2.3	-1.2	-0.9	-1.5	1.2	-1.2	-1.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	-0.1	0.3	-0.2	0.2	0.3
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	0.2	0.1	-0.1	-0.1
Weight adjusted by age	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.4	-0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.1	0.1	0.1
Locomotion in novel chamber	5.1	6.2	7.7	2.7	1.8	2.1	-2.7	2.7	2.8
Locomotion in novel chamber post-restriction	0.8	0.9	1.1	1.0	0.7	1.0	-1.0	1.0	1.1
Progressive ratio	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	0.1	0.2
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.5	0.4	0.4	-0.5	0.5	0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	0.4	0.3
Run reversals in cocaine runway, females	2.5	2.5	3.0	-1.7	-1.3	-1.4	1.6	-1.6	-1.7
Run reversals in cocaine runway, males	0.6	0.6	0.6	0.8	0.7	0.7	-0.8	0.8	0.7
Latency to leave start box in cocaine runway	3.1	3.4	4.4	-1.7	-1.9	-2.1	1.8	-1.8	-1.7
Latency to leave start box in cocaine runway, F	2.7	2.9	3.6	-1.6	-1.8	-1.9	1.7	-1.7	-1.6
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	-0.3	-0.6	-0.9	0.4	-0.4	-0.3
Cd content in liver	0.1	0.1	0.2	0.3	0.3	0.4	-0.3	0.3	0.3
Co content in liver	1.3	1.5	1.7	-1.2	-1.3	-1.2	1.3	-1.3	-1.2
Cu content in liver	0.8	0.9	1.4	-0.9	-1.1	-1.2	0.9	-1.0	-0.8
Fe content in liver	1.5	1.7	1.9	-1.3	-1.4	-1.3	1.3	-1.3	-1.3
K content in liver	0.4	0.4	0.7	0.7	0.3	0.2	-0.7	0.7	0.8
Mg content in liver	0.3	0.4	0.6	0.7	0.3	0.3	-0.7	0.7	0.8
Mn content in liver	0.6	0.7	1.1	1.0	0.6	0.5	-0.9	0.9	1.1
Na content in liver	0.2	0.2	0.3	0.5	0.3	0.2	-0.5	0.5	0.6
Rb content in liver	1.2	1.5	1.7	1.3	1.2	1.1	-1.2	1.2	1.3
Se content in liver	2.6	3.2	4.2	1.9	1.5	1.4	-1.9	1.9	2.0
Sr content in liver	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.3	-0.3	-0.3
Zn content in liver	1.9	2.1	2.3	1.5	1.5	1.3	-1.4	1.4	1.5