Hub : Genes

Mta2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000019913 0.07 0.05 5.9e-04 0.01 0.02 0.01 0.02 1.5e-02 2.7e-03 1.2e-02 3.4e-03
2 Eye gene expression ENSRNOG00000019913 0.55 0.17 6.9e-04 0.12 0.1 0.1 0.1 6.7e-03 1.4e-02 1.3e-02 1.3e-02
3 LHb gene expression ENSRNOG00000019913 0.12 0.08 6.6e-03 -0 0.05 -0.01 -0.01 3.4e-01 2.7e-02 8.1e-01 6.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.34.26.0-1.0-2.5-2.4
BMI without tail1.02.02.3-1.3-1.5-1.4
Body weight2.912.116.2-2.3-4.0-3.9
Epididymis fat weight0.40.91.30.61.11.1
Glucose2.74.15.31.42.32.3
Heart weight0.60.91.4-0.50.91.2
Left kidney weight0.10.10.40.70.1-0.1
Right kidney weight0.20.51.41.2-0.2-0.4
Tail length1.23.53.8-1.8-1.9-1.9
Length with tail2.07.59.9-1.8-3.1-3.1
Length without tail1.43.14.5-0.7-2.1-2.1
Liver weight, left0.20.30.6-0.10.60.8
Liver weight, right0.10.10.2-0.5-0.10.2
Parametrial fat weight1.63.13.51.71.71.9
Retroperitoneal fat weight1.96.29.61.22.73.1
Intraocular pressure0.10.20.30.50.60.2
Extensor digitorum longus weight5.020.227.7-2.5-5.3-5.2
Soleus weight1.85.38.90.92.53.0
Tibialis anterior weight7.826.938.0-2.3-6.1-6.2
Tibia length1.03.04.31.6-1.4-2.1
Number of licking bursts0.00.00.00.0-0.20.1
Food consumed during 24 hour testing period0.30.30.50.70.60.3
Times rat made contact with spout0.60.71.4-1.2-0.7-0.4
Mean time between licks in bursts1.92.76.3-2.5-1.0-0.9
Mean num. licks in bursts0.10.10.3-0.60.10.0
Std. dev. time between licks in bursts0.70.92.3-1.50.30.4
Water consumed over 24 hours0.50.60.7-0.9-0.8-0.7
Indifference point 0 sec0.50.81.2-0.6-1.1-1.0
Indifference point AUC1.51.73.10.9-1.1-1.7
Indifference point function ln k2.53.56.0-1.61.42.5
Indifference point function log k2.53.56.0-1.61.42.5
Delay discounting total patch changes 0 sec0.71.21.4-1.1-1.2-1.0
Delay discounting total patch changes 12 sec4.86.310.4-0.6-2.9-3.2
Delay discounting total patch changes 18 sec0.40.50.90.3-0.8-1.0
Delay discounting total patch changes 24 sec6.17.711.1-1.3-3.3-3.2
Delay discounting total patch changes 6 sec1.01.52.1-0.8-1.4-1.4
Delay discounting time to switch 0 sec0.30.50.70.8-0.5-0.7
Delay discounting water rate 0 sec0.30.40.7-0.50.60.8
Delay discounting water rate 12 sec1.32.02.9-1.51.01.7
Delay discounting water rate 18 sec1.21.63.8-2.00.21.0
Delay discounting water rate 24 sec0.81.22.0-0.81.01.4
Delay discounting water rate 6 sec1.01.42.0-1.40.71.4
Locomotor activity0.81.32.6-1.60.51.0
Locomotor testing distance1.21.94.4-2.10.41.1
Locomotor testing rearing0.81.31.6-1.11.01.3
Light reinforcement 10.00.10.1-0.00.30.4
Light reinforcement 21.82.35.82.41.00.5
Reaction time number correct0.71.01.6-1.3-0.8-0.8
Reaction time mean minus median0.91.23.11.80.1-0.7
Reaction time mean minus median AUC0.30.41.01.00.1-0.5
Reaction time num false alarms0.81.13.1-1.80.20.4
Reaction time num false alarms AUC1.21.74.7-2.2-0.5-0.2
Reaction time trials correct on left0.71.01.6-1.3-0.8-0.8
Reaction time trials on left0.71.01.6-1.3-0.8-0.9
Reaction time mean0.60.92.21.50.60.1
Reaction time mean AUC0.81.12.51.60.80.3
Median of all reaction times0.30.41.01.00.2-0.1
Reaction time omissions0.10.10.2-0.1-0.2-0.4
Reaction time false alarm rate0.40.51.4-1.20.10.4
Reaction time premature initiation rate4.56.06.9-2.5-2.6-2.3
Reaction time premature initiations5.88.39.0-3.0-3.0-2.7
Std. dev. reaction times0.71.02.51.60.70.1
Reaction time trials completed0.71.01.6-1.3-0.8-0.9
Reaction time trials AUC0.60.91.6-1.3-0.8-0.7
Social response proportion0.10.10.3-0.5-0.0-0.3
Social responses0.20.30.6-0.8-0.3-0.3
Social time0.20.30.6-0.8-0.4-0.1
Conditioned locomotion0.60.71.0-0.6-1.0-0.9
Cocaine response after cond. corrected0.50.61.0-1.00.10.9
Cocaine response after cond. not corrected0.40.40.7-0.60.40.8
Cocaine response before conditioning0.40.50.91.00.5-0.5
Saline control response2.43.23.8-1.6-2.0-1.8
Condit. Reinf. active minus inactive responses0.91.12.21.50.90.6
Condit. Reinf. active-inactive response ratio2.52.75.92.41.20.8
Condit. Reinf. active responses0.00.10.20.40.10.0
Condit. Reinf. inactive responses0.70.92.4-1.6-0.5-0.3
Condit. Reinf. lever presses0.40.51.00.4-0.6-1.0
Condit. Reinf. lever reinforcers received0.10.10.20.4-0.1-0.3
Pavlov. Cond. lever latency0.10.20.4-0.20.40.6
Pavlov. Cond. magazine entry latency2.42.85.6-0.5-1.6-2.4
Pavlov. Cond. change in total contacts0.71.01.71.0-0.6-1.3
Pavlov. Cond. index score1.11.53.20.4-1.0-1.8
Pavlov. Cond. latency score1.01.32.80.5-0.9-1.7
Pavlov. Cond. lever contacts0.10.20.40.3-0.1-0.6
Pavlov. Cond. magazine entry number4.04.99.50.32.23.1
Pavlov. Cond. intertrial magazine entries1.21.52.20.91.21.5
Pavlov. Cond. lever-magazine prob. diff.1.31.73.70.3-1.1-1.9
Pavlov. Cond. response bias0.70.92.10.0-0.8-1.5
Conditioned reinforcement - actives3.13.14.02.01.81.4
Conditioned reinforcement - inactives1.82.13.31.81.31.1
Conditioned locomotion2.02.42.81.41.61.7
Intermittent access intake day 1-15 change2.32.33.41.91.61.0
Intermittent access intake escalation1.61.52.51.61.30.8
Intermittent access intake escalation 20.70.71.81.30.4-0.1
Intermitt. access day 1 inactive lever presses1.81.92.21.21.41.5
Intermitt. access day 15 inactive lever presses0.50.51.51.20.2-0.1
Intermitt. access escalation Index0.40.40.9-0.90.10.5
Intermittent access day 1 total infusions0.91.11.30.91.01.1
Intermittent access day 15 total infusions4.55.05.52.32.32.0
Intermittent access terminal intake (last 3 days)2.02.24.42.11.20.9
Intermittent access total infusions1.82.02.91.71.31.1
Intermittent access day 1 locomotion0.10.10.3-0.00.20.5
Intermittent access day 15 total locomotion0.60.71.41.20.60.4
Intermittent access total locomotion0.91.02.51.60.50.5
Intermittent access standard deviation1.81.92.41.41.51.1
Cocaine induced anxiety0.20.20.30.5-0.3-0.6
Post-drug Anxiety0.50.60.80.7-0.6-0.9
Baseline Anxiety1.11.21.4-0.9-1.2-1.2
Lifetime Intake1.11.21.41.01.21.1
Incentive Sensitization - Responses0.30.30.80.90.1-0.2
Incentive Sensitization - Breakpoint0.40.41.11.00.2-0.1
Progressive ratio test 1 active lever presses1.92.02.61.11.61.5
Progressive ratio test 1 breakpoint2.22.33.01.21.71.6
Progressive ratio test 1 inactive lever presses0.10.10.3-0.6-0.2-0.2
Progressive ratio test 2 active lever presses2.52.73.21.81.71.4
Progressive ratio test 2 breakpoint3.43.84.52.02.11.8
Progressive ratio test 2 inactive lever presses1.51.72.71.61.30.9
Total sessions with >9 infusions1.31.42.30.31.41.5
Short access day 1 total inactive lever presses0.60.71.20.20.91.1
Short access day 10 total inactive lever presses1.51.63.0-0.31.31.7
Short access day 1 total infusions0.70.81.20.11.01.1
Short access day 10 total infusions0.30.30.50.40.60.7
Short access total infusions0.30.40.7-0.10.70.8
Short access day 1 locomotion0.10.10.1-0.4-0.2-0.0
Short access day 10 total locomotion0.00.00.00.1-0.20.1
Short access total locomotion0.10.10.2-0.3-0.4-0.2
Compulsive drug intake3.43.46.7-2.6-1.4-1.1
One hour access (0.3 mA shock)4.04.75.31.92.32.3
One hour access (shock baseline)7.28.310.73.32.82.5
Number of responses in last shaping day0.30.31.0-1.0-0.1-0.0
Context. condit. distance diff. score0.20.20.4-0.50.20.7
Locomotion velocity, session 10.60.61.6-1.3-0.6-0.0
Locomotion distance, session 11.11.42.1-1.3-1.5-0.7
Locomotion velocity, session 22.42.84.3-0.8-2.1-1.8
Locomotion distance, session 20.60.91.2-1.1-1.1-0.6
Locomotion velocity, session 30.40.40.7-0.7-0.8-0.3
Locomotion distance, session 30.20.30.6-0.8-0.4-0.1
Stereotopy head waving bouts, day 30.10.10.10.1-0.30.4
Stereotopy head waving duration, day 30.10.10.1-0.2-0.40.4
Locomotion velocity, session 70.00.00.10.3-0.10.2
Locomotion distance, session 70.20.20.6-0.8-0.10.4
Stereotopy head waving bouts, day 70.40.40.90.9-0.6-0.3
Stereotopy head waving duration, day 71.31.62.5-0.1-1.5-1.6
Locomotion velocity, session 80.50.61.6-1.3-0.50.1
Locomotion distance, session 80.10.10.3-0.1-0.00.6
Degree of sensitization distance0.00.00.10.10.10.3
Degree of sensitization stereotypy0.80.91.10.7-1.0-1.0
Condit. Reinf. active minus inactive responses0.70.81.2-0.3-1.1-1.1
Condit. Reinf. active-inactive response ratio0.40.40.5-0.6-0.7-0.7
Condit. Reinf. active responses0.60.71.00.5-0.9-1.0
Condit. Reinf. inactive responses0.60.71.91.40.40.1
Incentive salience index mean0.81.01.4-0.3-1.2-1.2
Condit. Reinf. lever presses0.40.50.8-0.2-0.9-0.8
Time in familiar zone, hab. session 10.00.00.0-0.20.1-0.2
Time in novel zone, hab. session 10.90.81.5-0.21.01.2
Total zone transitions, hab. session 10.40.61.2-0.5-1.1-0.7
Total locomotion distance, hab. session 10.10.20.50.7-0.20.3
Locomotion velocity, hab. session 10.20.30.50.4-0.7-0.4
Time in familiar zone, hab. session 20.50.50.6-0.80.70.6
Time in novel zone, hab. session 20.40.40.60.0-0.8-0.7
Total zone transitions, hab. session 21.62.12.9-1.3-1.7-1.3
Total locomotion distance, hab. session 20.20.20.5-0.4-0.7-0.2
Locomotion velocity, hab. session 20.10.10.3-0.0-0.6-0.1
Novel to familiar place preference ratio1.21.32.50.2-1.2-1.6
Novelty place preference0.70.71.40.3-0.8-1.2
Time in novel zone, NPP test0.70.81.50.1-0.8-1.2
Total zone transitions, NPP test1.52.23.3-1.2-1.8-1.3
Total locomotion distance, NPP test0.30.40.6-0.7-0.8-0.3
Locomotion velocity, NPP test0.20.30.5-0.5-0.7-0.2
Pavlov. Cond. lever latency0.60.81.2-0.11.01.1
Pavlov. Cond. magazine entry latency0.50.71.10.8-0.5-1.0
Pavlov. Cond. change in total contacts0.70.82.21.50.1-0.5
Pavlov. Cond. index score0.30.40.60.6-0.4-0.8
Pavlov. Cond. latency score0.20.30.50.4-0.4-0.7
Pavlov. Cond. lever contacts0.10.10.20.2-0.3-0.4
Pavlov. Cond. magazine entry number0.50.60.9-0.90.30.9
Pavlov. Cond. intertrial magazine entries0.20.20.60.80.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.60.90.8-0.5-0.9
Pavlov. Cond. response bias0.40.50.80.8-0.4-0.9
Bone: apparent density0.10.20.20.2-0.5-0.5
Bone surface0.91.62.70.6-1.3-1.6
Bone volume0.50.81.01.0-0.7-0.9
Bone: connectivity density0.91.42.3-0.4-1.3-1.5
Bone: cortical apparent density0.60.71.2-0.5-1.1-0.9
Bone: cortical area0.40.71.10.4-0.9-1.0
Bone: cortical porosity0.00.00.10.2-0.10.0
Bone: cortical porosity0.10.10.2-0.2-0.4-0.3
Bone: cortical thickness2.94.75.7-1.8-2.3-2.4
Bone: cortical thickness0.91.11.9-1.4-0.9-0.8
Bone: cortical tissue density0.70.91.4-0.6-1.2-1.0
Bone: elastic displacement0.40.40.6-0.80.50.7
Bone: elastic work1.41.93.0-1.7-1.2-1.0
Bone: endosteal estimation1.63.44.02.01.71.8
Bone: endosteal perimeter3.16.59.83.12.22.2
Bone: final force1.22.03.0-0.2-1.7-1.7
Bone: final moment1.11.92.8-0.2-1.7-1.7
Bone: marrow area1.73.74.02.01.81.9
Bone: maximum diameter0.40.72.01.4-0.2-0.3
Bone: maximum force1.32.23.60.3-1.7-1.9
Bone: maximum moment1.22.13.40.3-1.7-1.8
Bone: minimum diameter1.22.23.41.91.21.2
Bone: periosteal estimation0.51.12.91.70.40.4
Bone: periosteal perimeter0.61.02.71.70.40.2
Bone: post-yield work1.92.66.32.51.00.7
Bone: stiffness0.50.80.91.0-0.7-1.0
Bone: tissue strength0.30.30.50.00.70.6
Bone: trabecular number0.30.50.80.2-0.7-0.9
Bone: trabecular spacing0.30.40.7-0.90.50.5
Bone: trabecular thickness0.80.91.91.40.70.6
Bone: trabecular tissue density2.63.76.00.82.12.5
Breakpoint value in progressive ratio session1.21.42.80.0-1.2-1.7
Distance traveled before self-admin1.41.52.60.3-1.3-1.6
Distance traveled after self-admin0.20.20.30.4-0.3-0.6
Delta time in closed arm before/after self-admin4.03.97.2-2.7-1.8-1.2
Delta time in open arm before/after self-admin1.21.21.71.0-0.9-1.3
Diff in mean of infusions in LGA sessions1.51.72.6-0.7-1.4-1.6
Extinction: sum of active levers before priming2.82.84.4-0.4-2.0-2.1
Active lever presses in extinction session 61.71.63.10.4-1.3-1.8
Delta distance traveled before/after self-admin0.40.40.7-0.50.60.8
Delta ambulatory time before/after self-admin0.60.71.1-0.60.81.0
Time in closed arm before self-admin0.50.61.61.30.50.1
Time in closed arm after self-admin0.40.40.6-0.50.60.8
Time in open arm before self-admin1.51.64.0-2.00.20.9
Time in open arm after self-admin0.10.20.2-0.5-0.4-0.3
Sum of active levers in priming session hrs 5-61.41.42.51.6-0.5-1.2
Time to tail flick, vehicle, before self-admin0.20.20.30.4-0.5-0.6
Time to tail flick, vehicle, after self-admin0.80.81.3-1.1-0.9-0.6
Time to tail flick, test, before self-admin0.70.61.1-1.0-0.9-0.3
Time to tail flick, test, after self-admin0.10.10.10.20.30.3
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.8-0.4-0.1
Delta time to tail flick, test, before/after SA0.30.30.60.80.5-0.0
Ambulatory time before self-admin1.31.32.20.9-1.0-1.5
Ambulatory time after self-admin0.30.30.80.9-0.1-0.4
Total heroin consumption2.93.55.5-0.9-2.1-2.3
Area under the delay curve0.10.10.3-0.6-0.3-0.0
Delay disc. indifference point, 0s delay0.30.30.7-0.80.00.5
Delay disc. indifference point, 16s delay0.10.10.10.3-0.1-0.2
Delay disc. indifference point, 2s delay0.20.20.30.30.50.5
Delay disc. indifference point, 24s delay0.60.51.2-1.1-0.6-0.3
Delay disc. indifference point, 4s delay1.21.22.5-1.6-1.0-0.5
Delay disc. indifference point, 8s delay0.40.40.8-0.90.10.5
Delay discount exponential model param0.10.10.40.60.30.0
Delay discount hyperbolic model param0.10.20.40.60.30.1
Fecal boli incidents, locomotor time 11.51.73.81.91.00.5
Change in fecal boli incidents, locomotor task0.90.91.8-1.40.10.8
Time >=10cm from walls, locomotor time 13.93.95.82.41.81.6
Bouts of movement, locomotor time 10.10.20.40.3-0.1-0.6
Total resting periods, locomotor time 10.20.20.30.5-0.0-0.6
Rest time, locomotor task time 11.01.11.50.61.21.2
Distance moved, locomotor task time 10.20.20.2-0.3-0.5-0.5
Vertical activity count, locomotor time 10.40.50.80.20.70.9
Time >=10cm from walls, locomotor time 20.80.92.11.40.70.3
Bouts of movement, locomotor time 21.11.21.7-0.6-1.2-1.3
Total resting periods, locomotor time 20.50.50.8-0.3-0.8-0.9
Rest time, locomotor task time 22.42.84.20.81.92.1
Distance moved, locomotor task time 20.30.40.8-0.3-0.6-0.9
Vertical activity count, locomotor time 20.40.41.1-1.1-0.2-0.0
Weight adjusted by age0.91.01.90.1-1.0-1.4
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.3-0.1-0.1
Locomotion in novel chamber3.54.35.22.32.11.7
Locomotion in novel chamber post-restriction1.92.33.01.11.61.7
Progressive ratio0.10.10.40.70.00.1
Food seeking constrained by brief footshock0.20.20.6-0.7-0.10.3
Seeking ratio, punishment vs. effort0.50.72.0-1.4-0.20.1
Run reversals in cocaine runway, females2.22.23.9-2.0-1.4-0.7
Run reversals in cocaine runway, males0.30.30.50.10.60.7
Latency to leave start box in cocaine runway0.30.30.50.40.60.7
Latency to leave start box in cocaine runway, F0.00.00.00.20.0-0.1
Latency to leave start box in cocaine runway, M2.52.43.70.81.71.9
Cd content in liver1.21.31.51.11.21.2
Co content in liver1.21.42.0-1.11.11.4
Cu content in liver0.70.81.7-1.3-0.7-0.5
Fe content in liver0.10.10.30.50.10.0
K content in liver0.50.50.80.2-0.8-0.9
Mg content in liver0.20.20.30.1-0.6-0.4
Mn content in liver1.21.42.6-0.1-1.3-1.6
Na content in liver0.40.40.60.6-0.5-0.8
Rb content in liver0.91.12.3-0.11.11.5
Se content in liver0.70.82.21.50.1-0.5
Sr content in liver4.54.16.3-0.6-2.3-2.5
Zn content in liver2.93.25.1-0.2-2.1-2.3