Pavlov. Cond. response bias

Pavlovian Conditioned Approach, Sign/goal-tracking, average lever minus magazine contact number on days 4 and 5 of testing, normalized to 1/-1 by dividing by total contact number

Tags: Behavior · Learning and memory · Pavlovian conditioned approach

Project: p50_shelly_flagel_2014

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr2 175255218 176649376 1 1 1.34e-12 4.66e-03 2.49e-17 Ilf2

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
Left kidney weight 2.28 1 0 0 0 1e+00 Ilf2
Right kidney weight 2.38 1 0 0 0 1e+00 Ilf2
Liver weight, left 2.88 1 0 0 0 1e+00 Ilf2
Intraocular pressure 5.72 1 0 0 0 1e+00 Ilf2
Extensor digitorum longus weight 1.85 1 0 0 0 1e+00 Ilf2
Patch foraging total patch changes 12 sec 5.98 1 0 0 0 1e+00 Ilf2
Patch foraging time to switch 0 sec 2.52 1 0 0 0 1e+00 Ilf2
Patch foraging water rate 18 sec 3.4 1 0 0 0 1e+00 Ilf2
Locomotor activity 3.02 1 0 0 0 1e+00 Ilf2
Locomotor testing distance 2.69 1 0 0 0 1e+00 Ilf2
Light reinforcement 2 4.21 1 0 0 0 1e+00 Ilf2
Reaction time mean 2.9 1 0 0 0 1e+00 Ilf2
Reaction time mean AUC 3.59 1 0 0 0 1e+00 Ilf2
Reaction time premature initiation rate 20.51 1 1 100 0 1e+00 Ilf2
Reaction time premature initiations 12.93 1 0 0 0 1e+00 Ilf2
Std. dev. reaction times 3.86 1 0 0 0 1e+00 Ilf2
Social response proportion 11.26 1 0 0 0 1e+00 Ilf2
Social time 4.65 1 0 0 0 1e+00 Ilf2
Conditioned reinforcement - inactives 4.5 1 0 0 0 1e+00 Ilf2
Conditioned locomotion 6.8 1 0 0 0 1e+00 Ilf2
Intermittent access intake day 1-15 change 5.14 1 0 0 0 1e+00 Ilf2
Intermittent access intake escalation 2 6.44 1 0 0 0 1e+00 Ilf2
Intermitt. access escalation Index 4.8 1 0 0 0 1e+00 Ilf2
Intermittent access day 1 locomotion 5.42 1 0 0 0 1e+00 Ilf2
Intermittent access day 15 total locomotion 5.95 1 0 0 0 1e+00 Ilf2
Intermittent access total locomotion 6.46 1 0 0 0 1e+00 Ilf2
Intermittent access standard deviation 3.81 1 0 0 0 1e+00 Ilf2
Progressive ratio test 2 inactive lever presses 3.96 1 0 0 0 1e+00 Ilf2
Short access day 10 total infusions 3.77 1 0 0 0 1e+00 Ilf2
Short access day 10 total locomotion 3.47 1 0 0 0 1e+00 Ilf2
Locomotion velocity, session 2 6.62 1 0 0 0 1e+00 Ilf2
Stereotopy head waving bouts, day 3 7.08 1 0 0 0 1e+00 Ilf2
Stereotopy head waving duration, day 3 5.56 1 0 0 0 1e+00 Ilf2
Locomotion velocity, session 8 12.45 1 0 0 0 1e+00 Ilf2
Condit. Reinf. inactive responses 3.83 1 0 0 0 1e+00 Ilf2
Condit. Reinf. lever presses 10.84 1 0 0 0 1e+00 Ilf2
Novel to familiar place preference ratio 7.16 1 0 0 0 1e+00 Ilf2
Novelty place preference 6.43 1 0 0 0 1e+00 Ilf2
Time in novel zone, NPP test 4.7 1 0 0 0 1e+00 Ilf2
Pavlov. Cond. lever latency 21.9 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. magazine entry latency 28.91 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. change in total contacts 18.74 1 0 0 0 1e+00 Ilf2
Pavlov. Cond. index score 34.08 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. latency score 30.82 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. lever contacts 37.24 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. magazine entry number 42.75 1 1 100 0 1e+00 Ilf2
Pavlov. Cond. intertrial magazine entries 13.5 1 0 0 0 1e+00 Ilf2
Pavlov. Cond. lever-magazine prob. diff. 35.53 1 1 100 0 1e+00 Ilf2
Bone volume 3.15 1 0 0 0 1e+00 Ilf2
Bone: cortical area 8.85 1 0 0 0 1e+00 Ilf2
Bone: elastic work 4.68 1 0 0 0 1e+00 Ilf2
Bone: endosteal estimation 5.57 1 0 0 0 1e+00 Ilf2
Bone: endosteal perimeter 2.98 1 0 0 0 1e+00 Ilf2
Bone: final force 22.01 1 1 100 0 1e+00 Ilf2
Bone: final moment 20.22 1 1 100 0 1e+00 Ilf2
Bone: marrow area 5.59 1 0 0 0 1e+00 Ilf2
Bone: maximum force 24.61 1 1 100 0 1e+00 Ilf2
Bone: maximum moment 21.5 1 1 100 0 1e+00 Ilf2
Bone: minimum diameter 7.24 1 0 0 0 1e+00 Ilf2
Bone: periosteal estimation 7.49 1 0 0 0 1e+00 Ilf2
Bone: periosteal perimeter 4.34 1 0 0 0 1e+00 Ilf2
Bone: post-yield work 5.96 1 0 0 0 1e+00 Ilf2
Bone: stiffness 12.05 1 0 0 0 1e+00 Ilf2
Distance traveled before self-admin 4.78 1 0 0 0 1e+00 Ilf2
Distance traveled after self-admin 5.06 1 0 0 0 1e+00 Ilf2
Delta time in open arm before/after self-admin 7.55 1 0 0 0 1e+00 Ilf2
Time in open arm before self-admin 9.47 1 0 0 0 1e+00 Ilf2
Time to tail flick, test, before self-admin 5.28 1 0 0 0 1e+00 Ilf2
Delta time to tail flick, test, before/after SA 4.98 1 0 0 0 1e+00 Ilf2
Ambulatory time after self-admin 5.09 1 0 0 0 1e+00 Ilf2
Bouts of movement, locomotor time 2 4.23 1 0 0 0 1e+00 Ilf2
Total resting periods, locomotor time 2 3.88 1 0 0 0 1e+00 Ilf2
Rest time, locomotor task time 2 4.3 1 0 0 0 1e+00 Ilf2
Distance moved, locomotor task time 2 9.43 1 0 0 0 1e+00 Ilf2
Seeking ratio, delayed vs. immediate footshock 3.47 1 0 0 0 1e+00 Ilf2
Locomotion in novel chamber 4.37 1 0 0 0 1e+00 Ilf2
Progressive ratio 12.89 1 0 0 0 1e+00 Ilf2
Seeking ratio, punishment vs. effort 3.9 1 0 0 0 1e+00 Ilf2
Run reversals in cocaine runway, males 6.86 1 0 0 0 1e+00 Ilf2
Latency to leave start box in cocaine runway 7.72 1 0 0 0 1e+00 Ilf2
Latency to leave start box in cocaine runway, M 14.76 1 0 0 0 1e+00 Ilf2
Cd content in liver 13.38 1 0 0 0 1e+00 Ilf2
Na content in liver 4.96 1 0 0 0 1e+00 Ilf2
Sr content in liver 7.23 1 0 0 0 1e+00 Ilf2
Zn content in liver 4.99 1 0 0 0 1e+00 Ilf2

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.25
Adipose alternative TSS 0 0 1.22
Adipose gene expression 0 0 1.23
Adipose isoform ratio 0 0 1.2
Adipose intron excision ratio 0 0 1.23
Adipose mRNA stability 0 0 1.2
BLA alternative polyA 0 0 1.26
BLA alternative TSS 0 0 1.18
BLA gene expression 0 0 1.21
BLA isoform ratio 0 0 1.24
BLA intron excision ratio 0 0 1.26
BLA mRNA stability 0 0 1.2
Brain alternative polyA 0 0 1.23
Brain alternative TSS 0 0 1.17
Brain gene expression 0 0 1.23
Brain isoform ratio 0 0 1.19
Brain intron excision ratio 0 0 1.27
Brain mRNA stability 0 0 1.2
Eye alternative polyA 0 0 1.2
Eye alternative TSS 0 0 1.26
Eye gene expression 0 0 1.22
Eye isoform ratio 0 0 1.32
Eye intron excision ratio 0 0 1.33
Eye mRNA stability 0 0 1.27
IL alternative polyA 0 0 1.18
IL alternative TSS 0 0 1.39
IL gene expression 0 0 1.18
IL isoform ratio 0 0 1.31
IL intron excision ratio 0 0 1.33
IL mRNA stability 0 0 1.24
LHb alternative polyA 0 0 1.19
LHb alternative TSS 0 0 1.17
LHb gene expression 0 0 1.19
LHb isoform ratio 0 0 1.21
LHb intron excision ratio 0 0 1.21
LHb mRNA stability 0 0 1.27
Liver alternative polyA 0 0 1.22
Liver alternative TSS 0 0 1.07
Liver gene expression 0 0 1.21
Liver isoform ratio 0 0 1.18
Liver intron excision ratio 0 0 1.19
Liver mRNA stability 0 0 1.22
NAcc alternative polyA 0 0 1.24
NAcc alternative TSS 0 0 1.13
NAcc gene expression 1 0 1.23
NAcc isoform ratio 0 0 1.22
NAcc intron excision ratio 0 0 1.25
NAcc mRNA stability 0 0 1.18
OFC alternative polyA 0 0 1.22
OFC alternative TSS 0 0 1.14
OFC gene expression 0 0 1.21
OFC isoform ratio 0 0 1.21
OFC intron excision ratio 0 0 1.45
OFC mRNA stability 0 0 1.17
PL alternative polyA 0 0 1.22
PL alternative TSS 0 0 1.25
PL gene expression 0 0 1.24
PL isoform ratio 0 0 1.19
PL intron excision ratio 0 0 1.23
PL mRNA stability 0 0 1.19
pVTA alternative polyA 0 0 1.18
pVTA alternative TSS 0 0 1.2
pVTA gene expression 0 0 1.18
pVTA isoform ratio 0 0 1.23
pVTA intron excision ratio 0 0 1.26
pVTA mRNA stability 0 0 1.15
RMTg alternative polyA 0 0 1.16
RMTg alternative TSS 0 0 1.27
RMTg gene expression 0 0 1.25
RMTg isoform ratio 0 0 1.18
RMTg intron excision ratio 0 0 1.26
RMTg mRNA stability 0 0 1.19