Hub : Genes

Rarg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability ENSRNOG00000012499 0.05 0.04 1.3e-03 0.03 0.03 0.01 0.03 2e-03 1.1e-03 5.9e-02 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail2.37.47.42.7
BMI without tail0.30.70.70.8
Body weight0.62.32.31.5
Epididymis fat weight1.74.04.0-2.0
Glucose0.40.60.6-0.8
Heart weight0.10.10.1-0.3
Left kidney weight0.30.80.80.9
Right kidney weight1.02.82.81.7
Tail length0.41.11.1-1.1
Length with tail0.10.40.4-0.6
Length without tail0.10.10.10.3
Liver weight, left0.40.70.70.8
Liver weight, right0.20.40.40.6
Parametrial fat weight3.16.26.2-2.5
Retroperitoneal fat weight1.86.16.1-2.5
Intraocular pressure0.30.40.4-0.6
Extensor digitorum longus weight7.731.131.15.6
Soleus weight0.20.70.70.8
Tibialis anterior weight7.325.325.35.0
Tibia length0.41.21.21.1
Number of licking bursts0.00.00.00.0
Food consumed during 24 hour testing period0.00.00.00.1
Times rat made contact with spout0.10.10.10.3
Mean time between licks in bursts1.11.51.5-1.2
Mean num. licks in bursts0.00.00.0-0.1
Std. dev. time between licks in bursts0.91.11.1-1.0
Water consumed over 24 hours0.00.00.00.2
Indifference point 0 sec0.71.11.1-1.1
Indifference point AUC0.20.30.3-0.5
Indifference point function ln k1.62.32.31.5
Indifference point function log k1.62.32.31.5
Delay discounting total patch changes 0 sec1.11.71.7-1.3
Delay discounting total patch changes 12 sec1.72.32.3-1.5
Delay discounting total patch changes 18 sec1.62.12.1-1.4
Delay discounting total patch changes 24 sec0.00.00.0-0.2
Delay discounting total patch changes 6 sec0.71.11.1-1.0
Delay discounting time to switch 0 sec0.20.30.3-0.6
Delay discounting water rate 0 sec0.30.50.50.7
Delay discounting water rate 12 sec0.00.10.10.2
Delay discounting water rate 18 sec0.10.10.10.3
Delay discounting water rate 24 sec0.71.01.01.0
Delay discounting water rate 6 sec1.42.02.01.4
Locomotor activity0.10.10.1-0.3
Locomotor testing distance0.61.11.1-1.0
Locomotor testing rearing0.00.00.0-0.2
Light reinforcement 10.71.31.3-1.1
Light reinforcement 21.62.12.1-1.5
Reaction time number correct0.00.10.10.3
Reaction time mean minus median0.30.40.4-0.7
Reaction time mean minus median AUC0.20.30.3-0.6
Reaction time num false alarms2.33.13.1-1.8
Reaction time num false alarms AUC2.43.33.3-1.8
Reaction time trials correct on left0.00.10.10.3
Reaction time trials on left0.00.00.00.1
Reaction time mean0.00.00.00.1
Reaction time mean AUC0.10.10.10.3
Median of all reaction times0.20.20.20.5
Reaction time omissions2.43.33.3-1.8
Reaction time false alarm rate1.31.91.9-1.4
Reaction time premature initiation rate0.91.21.2-1.1
Reaction time premature initiations0.50.70.7-0.8
Std. dev. reaction times0.20.20.2-0.5
Reaction time trials completed0.00.00.00.1
Reaction time trials AUC0.10.10.10.4
Social response proportion2.12.22.2-1.5
Social responses1.82.32.3-1.5
Social time1.41.91.9-1.4
Conditioned locomotion0.70.80.8-0.9
Cocaine response after cond. corrected1.01.11.1-1.1
Cocaine response after cond. not corrected1.21.31.3-1.1
Cocaine response before conditioning0.20.20.2-0.4
Saline control response0.00.00.0-0.2
Condit. Reinf. active minus inactive responses0.81.01.01.0
Condit. Reinf. active-inactive response ratio0.60.70.70.8
Condit. Reinf. active responses0.81.11.11.1
Condit. Reinf. inactive responses0.00.00.0-0.0
Condit. Reinf. lever presses0.40.60.6-0.8
Condit. Reinf. lever reinforcers received0.10.20.20.5
Pavlov. Cond. lever latency1.52.12.11.5
Pavlov. Cond. magazine entry latency3.74.34.3-2.1
Pavlov. Cond. change in total contacts0.20.20.20.5
Pavlov. Cond. index score2.83.63.6-1.9
Pavlov. Cond. latency score2.53.13.1-1.8
Pavlov. Cond. lever contacts2.43.43.4-1.8
Pavlov. Cond. magazine entry number1.21.41.41.2
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.3
Pavlov. Cond. lever-magazine prob. diff.1.92.52.5-1.6
Pavlov. Cond. response bias2.02.82.8-1.7
Conditioned reinforcement - actives0.10.10.1-0.3
Conditioned reinforcement - inactives1.21.41.4-1.2
Conditioned locomotion0.00.00.0-0.2
Intermittent access intake day 1-15 change0.00.00.00.1
Intermittent access intake escalation0.20.20.20.4
Intermittent access intake escalation 20.20.20.20.5
Intermitt. access day 1 inactive lever presses0.00.00.00.2
Intermitt. access day 15 inactive lever presses0.60.60.6-0.8
Intermitt. access escalation Index0.80.70.70.9
Intermittent access day 1 total infusions0.20.30.3-0.5
Intermittent access day 15 total infusions0.30.40.4-0.6
Intermittent access terminal intake (last 3 days)0.00.00.0-0.1
Intermittent access total infusions0.00.00.00.1
Intermittent access day 1 locomotion0.20.20.2-0.5
Intermittent access day 15 total locomotion0.00.00.0-0.0
Intermittent access total locomotion0.00.00.0-0.0
Intermittent access standard deviation0.50.60.6-0.7
Cocaine induced anxiety0.80.90.91.0
Post-drug Anxiety4.55.05.02.2
Baseline Anxiety0.10.10.10.4
Lifetime Intake0.00.00.0-0.0
Incentive Sensitization - Responses1.41.41.41.2
Incentive Sensitization - Breakpoint2.02.02.01.4
Progressive ratio test 1 active lever presses1.81.91.9-1.4
Progressive ratio test 1 breakpoint1.51.61.6-1.3
Progressive ratio test 1 inactive lever presses0.91.01.0-1.0
Progressive ratio test 2 active lever presses0.00.00.00.1
Progressive ratio test 2 breakpoint0.00.00.00.2
Progressive ratio test 2 inactive lever presses0.10.10.1-0.3
Total sessions with >9 infusions1.01.11.11.0
Short access day 1 total inactive lever presses0.10.10.1-0.4
Short access day 10 total inactive lever presses0.30.40.40.6
Short access day 1 total infusions0.10.10.1-0.3
Short access day 10 total infusions0.50.60.6-0.8
Short access total infusions0.00.00.0-0.0
Short access day 1 locomotion0.40.40.4-0.7
Short access day 10 total locomotion0.40.50.5-0.7
Short access total locomotion0.50.50.5-0.7
Compulsive drug intake3.73.63.61.9
One hour access (0.3 mA shock)4.45.15.12.3
One hour access (shock baseline)1.31.51.51.2
Number of responses in last shaping day4.54.64.6-2.1
Context. condit. distance diff. score0.60.70.70.8
Locomotion velocity, session 16.87.37.3-2.7
Locomotion distance, session 13.03.93.9-2.0
Locomotion velocity, session 22.93.43.4-1.8
Locomotion distance, session 23.85.55.5-2.3
Locomotion velocity, session 34.35.05.0-2.2
Locomotion distance, session 32.22.42.4-1.5
Stereotopy head waving bouts, day 31.41.61.61.3
Stereotopy head waving duration, day 30.10.10.10.3
Locomotion velocity, session 71.51.71.7-1.3
Locomotion distance, session 73.74.74.7-2.2
Stereotopy head waving bouts, day 71.51.71.71.3
Stereotopy head waving duration, day 72.22.72.71.6
Locomotion velocity, session 80.10.10.1-0.2
Locomotion distance, session 81.62.32.3-1.5
Degree of sensitization distance0.00.00.0-0.1
Degree of sensitization stereotypy2.02.22.21.5
Condit. Reinf. active minus inactive responses0.50.60.6-0.8
Condit. Reinf. active-inactive response ratio0.30.40.4-0.6
Condit. Reinf. active responses1.51.91.9-1.4
Condit. Reinf. inactive responses2.73.13.1-1.8
Incentive salience index mean0.10.10.1-0.4
Condit. Reinf. lever presses0.20.20.20.5
Time in familiar zone, hab. session 10.60.60.6-0.8
Time in novel zone, hab. session 11.31.31.31.1
Total zone transitions, hab. session 10.30.50.5-0.7
Total locomotion distance, hab. session 11.72.52.5-1.6
Locomotion velocity, hab. session 11.31.81.8-1.4
Time in familiar zone, hab. session 20.70.70.70.8
Time in novel zone, hab. session 20.00.00.0-0.0
Total zone transitions, hab. session 21.21.51.5-1.2
Total locomotion distance, hab. session 21.41.91.9-1.4
Locomotion velocity, hab. session 21.62.22.2-1.5
Novel to familiar place preference ratio0.40.50.50.7
Novelty place preference0.40.40.40.6
Time in novel zone, NPP test0.60.60.60.8
Total zone transitions, NPP test4.05.85.8-2.4
Total locomotion distance, NPP test5.67.77.7-2.8
Locomotion velocity, NPP test5.57.97.9-2.8
Pavlov. Cond. lever latency1.92.42.4-1.6
Pavlov. Cond. magazine entry latency2.83.63.61.9
Pavlov. Cond. change in total contacts4.44.74.72.2
Pavlov. Cond. index score5.06.46.42.5
Pavlov. Cond. latency score5.16.66.62.6
Pavlov. Cond. lever contacts2.73.23.21.8
Pavlov. Cond. magazine entry number1.72.12.1-1.5
Pavlov. Cond. intertrial magazine entries4.45.35.3-2.3
Pavlov. Cond. lever-magazine prob. diff.4.86.16.12.5
Pavlov. Cond. response bias1.92.32.31.5
Bone: apparent density1.42.42.41.5
Bone surface3.25.75.72.4
Bone volume3.05.25.22.3
Bone: connectivity density0.00.10.10.3
Bone: cortical apparent density0.30.40.4-0.6
Bone: cortical area1.52.32.31.5
Bone: cortical porosity0.40.40.4-0.6
Bone: cortical porosity0.60.60.6-0.8
Bone: cortical thickness0.00.10.10.2
Bone: cortical thickness3.23.83.8-1.9
Bone: cortical tissue density0.40.60.6-0.7
Bone: elastic displacement5.25.95.9-2.4
Bone: elastic work2.33.03.0-1.7
Bone: endosteal estimation3.88.28.22.9
Bone: endosteal perimeter3.87.87.82.8
Bone: final force2.64.34.32.1
Bone: final moment3.55.85.82.4
Bone: marrow area3.88.28.22.9
Bone: maximum diameter1.01.91.91.4
Bone: maximum force3.35.75.72.4
Bone: maximum moment4.17.27.22.7
Bone: minimum diameter2.95.45.42.3
Bone: periosteal estimation4.08.28.22.9
Bone: periosteal perimeter3.86.36.32.5
Bone: post-yield work2.93.93.92.0
Bone: stiffness6.710.510.53.2
Bone: tissue strength2.42.32.31.5
Bone: trabecular number0.10.10.10.4
Bone: trabecular spacing0.10.20.20.4
Bone: trabecular thickness0.00.00.0-0.1
Bone: trabecular tissue density0.10.20.20.4
Breakpoint value in progressive ratio session2.73.13.11.7
Distance traveled before self-admin0.00.00.0-0.0
Distance traveled after self-admin0.10.10.1-0.3
Delta time in closed arm before/after self-admin0.50.50.50.7
Delta time in open arm before/after self-admin6.56.26.2-2.5
Diff in mean of infusions in LGA sessions0.30.30.30.5
Extinction: sum of active levers before priming4.44.44.42.1
Active lever presses in extinction session 60.90.80.80.9
Delta distance traveled before/after self-admin0.60.60.6-0.8
Delta ambulatory time before/after self-admin0.50.50.5-0.7
Time in closed arm before self-admin0.00.00.00.2
Time in closed arm after self-admin1.41.51.51.2
Time in open arm before self-admin1.81.91.91.4
Time in open arm after self-admin1.41.51.5-1.2
Sum of active levers in priming session hrs 5-60.00.00.00.0
Time to tail flick, vehicle, before self-admin0.00.00.00.0
Time to tail flick, vehicle, after self-admin0.70.70.70.9
Time to tail flick, test, before self-admin1.41.41.4-1.2
Time to tail flick, test, after self-admin1.11.11.11.1
Delta time to tail flick, vehicle, before/after SA0.80.80.80.9
Delta time to tail flick, test, before/after SA3.12.82.81.7
Ambulatory time before self-admin0.00.00.00.0
Ambulatory time after self-admin0.00.00.0-0.1
Total heroin consumption2.22.72.71.6
Area under the delay curve0.30.30.30.6
Delay disc. indifference point, 0s delay0.00.00.0-0.2
Delay disc. indifference point, 16s delay0.20.20.20.4
Delay disc. indifference point, 2s delay3.84.24.22.1
Delay disc. indifference point, 24s delay0.30.30.30.5
Delay disc. indifference point, 4s delay0.50.50.50.7
Delay disc. indifference point, 8s delay0.00.00.00.2
Delay discount exponential model param0.50.60.6-0.8
Delay discount hyperbolic model param0.80.90.9-0.9
Fecal boli incidents, locomotor time 13.74.14.1-2.0
Change in fecal boli incidents, locomotor task1.61.51.51.2
Time >=10cm from walls, locomotor time 10.60.60.6-0.8
Bouts of movement, locomotor time 11.11.21.2-1.1
Total resting periods, locomotor time 12.22.52.5-1.6
Rest time, locomotor task time 10.60.70.7-0.8
Distance moved, locomotor task time 10.80.80.80.9
Vertical activity count, locomotor time 11.01.11.11.0
Time >=10cm from walls, locomotor time 20.10.20.2-0.4
Bouts of movement, locomotor time 22.12.32.31.5
Total resting periods, locomotor time 22.02.22.21.5
Rest time, locomotor task time 20.60.60.6-0.8
Distance moved, locomotor task time 20.00.00.00.1
Vertical activity count, locomotor time 20.30.30.30.6
Weight adjusted by age0.30.40.4-0.6
Seeking ratio, delayed vs. immediate footshock0.10.10.1-0.4
Locomotion in novel chamber2.73.33.31.8
Locomotion in novel chamber post-restriction1.01.21.21.1
Progressive ratio0.00.10.10.2
Food seeking constrained by brief footshock0.00.00.0-0.0
Seeking ratio, punishment vs. effort0.10.10.1-0.3
Run reversals in cocaine runway, females0.10.10.10.3
Run reversals in cocaine runway, males0.00.00.0-0.1
Latency to leave start box in cocaine runway0.00.00.00.2
Latency to leave start box in cocaine runway, F0.30.30.3-0.6
Latency to leave start box in cocaine runway, M1.81.81.81.3
Cd content in liver0.30.30.3-0.6
Co content in liver1.01.21.21.1
Cu content in liver7.38.98.93.0
Fe content in liver0.20.20.2-0.4
K content in liver0.20.20.20.4
Mg content in liver0.00.00.00.2
Mn content in liver0.00.00.0-0.0
Na content in liver0.20.20.20.4
Rb content in liver0.91.11.11.0
Se content in liver1.72.12.1-1.4
Sr content in liver0.20.20.2-0.4
Zn content in liver1.51.61.6-1.3