Best TWAS P=3.236551e-10 · Best GWAS P=1.592392e-10 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Ralyl | intron excision ratio | chr2:87631467:87663759 | 0.06 | 0.02 | top1 | 1 | 0.02 | 3.7e-03 | 5.6 | -5.6 | 1.7e-08 | -0.84 | 0.09 | 0.03 | FALSE |
| 2 | LHb | Ralyl | alternative TSS | ENSRNOT00000015195 | 0.60 | 0.20 | enet | 18 | 0.22 | 5.1e-06 | 6.3 | 6.3 | 3.2e-10 | 0.98 | 0.19 | 0.80 | TRUE |
| 3 | LHb | Ralyl | alternative TSS | ENSRNOT00000100768 | 0.60 | 0.16 | enet | 5 | 0.27 | 4.0e-07 | 6.3 | -6.1 | 1.0e-09 | -0.98 | 0.34 | 0.65 | FALSE |
| 4 | LHb | Ralyl | alternative TSS | ENSRNOT00000015195 | 0.58 | 0.16 | enet | 17 | 0.20 | 1.7e-05 | 6.4 | 6.2 | 5.7e-10 | 0.97 | 0.22 | 0.77 | FALSE |
| 5 | LHb | Ralyl | alternative TSS | ENSRNOT00000100768 | 0.52 | 0.14 | enet | 6 | 0.22 | 6.6e-06 | 6.3 | -6.2 | 6.3e-10 | -0.98 | 0.31 | 0.67 | FALSE |
| 6 | LHb | Ralyl | gene expression | ENSRNOG00000011400 | 0.73 | 0.13 | top1 | 1 | 0.13 | 6.6e-04 | 5.4 | 5.4 | 8.7e-08 | 0.72 | 0.13 | 0.05 | FALSE |
| 7 | LHb | Ralyl | mRNA stability | ENSRNOG00000011400 | 0.41 | 0.10 | enet | 6 | 0.15 | 2.2e-04 | -4.6 | 5.9 | 3.7e-09 | 0.92 | 0.38 | 0.53 | FALSE |
| 8 | OFC | Ralyl | alternative TSS | ENSRNOT00000100768 | 0.33 | 0.11 | enet | 5 | 0.11 | 1.2e-03 | 4.7 | -5.7 | 1.0e-08 | -0.87 | 0.57 | 0.27 | FALSE |
| 9 | OFC | Ralyl | intron excision ratio | chr2:87663834:87750876 | 0.24 | 0.06 | top1 | 1 | 0.06 | 1.3e-02 | 5.6 | 5.6 | 2.0e-08 | 0.77 | 0.13 | 0.05 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.