Best TWAS P=2.16e-08 · Best GWAS P=2.35e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Slc43a2 | alternative polyA | NM_001105812.1 | 0.15 | 1035 | 0.07 | 1.3e-08 | -5.25 | 1.54e-07 | 0.78 | FALSE |
| Adipose | Slc43a2 | alternative polyA | XM_039085518.1 | 0.15 | 1035 | 0.07 | 1.8e-08 | 5.25 | 1.49e-07 | 0.78 | FALSE |
| Adipose | Slc43a2 | alternative polyA | NM_001105812.1 | 0.12 | 1 | 0.05 | 1.6e-06 | 5.47 | 4.58e-08 | 0.75 | FALSE |
| Adipose | Slc43a2 | alternative polyA | XM_039085518.1 | 0.12 | 1 | 0.05 | 1.5e-06 | -5.47 | 4.58e-08 | 0.75 | FALSE |
| Adipose | Slc43a2 | isoform ratio | NM_001105812.1 | 0.16 | 1035 | 0.06 | 6.6e-07 | -5.38 | 7.30e-08 | 0.78 | FALSE |
| Adipose | Slc43a2 | isoform ratio | XM_006246893.4 | 0.04 | 1 | 0.02 | 1.9e-03 | -5.47 | 4.58e-08 | 0.06 | FALSE |
| Adipose | Myo1c | intron excision ratio | chr10_60499487_60505081 | 0.08 | 1 | 0.03 | 1.2e-04 | -5.53 | 3.18e-08 | 0.37 | FALSE |
| Adipose | Crk | mRNA stability | Crk | 0.18 | 23 | 0.14 | 8.2e-16 | 5.41 | 6.35e-08 | 0.8 | FALSE |
| BLA | Rap1gap2 | alternative TSS | NM_001401654.1 | 0.08 | 1 | 0.04 | 4.8e-03 | 5.19 | 2.09e-07 | 0.06 | FALSE |
| BLA | Crk | gene expression | Crk | 0.16 | 1 | 0.11 | 1.5e-06 | -5.5 | 3.89e-08 | 0.65 | FALSE |
| BLA | Inpp5k | gene expression | Inpp5k | 0.2 | 1 | 0.17 | 1.7e-09 | -5.49 | 4.05e-08 | 0.8 | FALSE |
| BLA | Rtn4rl1 | gene expression | Rtn4rl1 | 0.17 | 1 | 0.09 | 1.4e-05 | -5.33 | 9.82e-08 | 0.44 | FALSE |
| BLA | Smyd4 | intron excision ratio | chr10_60200371_60201453 | 0.07 | 812 | 0.04 | 5.6e-03 | -5.54 | 3.06e-08 | 0.69 | FALSE |
| BLA | Crk | mRNA stability | Crk | 0.33 | 1 | 0.32 | 1.1e-17 | -5.49 | 3.98e-08 | 0.82 | FALSE |
| Brain | Crk | gene expression | Crk | 0.31 | 1179 | 0.27 | 1.3e-25 | 5.2 | 1.97e-07 | 0.83 | FALSE |
| Brain | Rap1gap2 | gene expression | Rap1gap2 | 0.39 | 16 | 0.53 | 3.0e-58 | 5.22 | 1.84e-07 | 0.78 | FALSE |
| Brain | Rtn4rl1 | gene expression | Rtn4rl1 | 0.58 | 1 | 0.18 | 1.4e-16 | -5.5 | 3.82e-08 | 0.8 | FALSE |
| Brain | Crk | mRNA stability | Crk | 0.46 | 3 | 0.27 | 3.5e-25 | 5.6 | 2.16e-08 | 0.82 | TRUE |
| Brain | Doc2b | mRNA stability | Doc2b | 0.65 | 51 | 0.43 | 2.3e-43 | 5.32 | 1.03e-07 | 0.84 | FALSE |
| Brain | Rap1gap2 | mRNA stability | Rap1gap2 | 0.15 | 5 | 0.18 | 7.8e-17 | 5.32 | 1.03e-07 | 0.84 | FALSE |
| Brain | Slc43a2 | mRNA stability | Slc43a2 | 0.11 | 3 | 0.1 | 6.1e-10 | -5.49 | 3.97e-08 | 0.78 | FALSE |
| Eye | Serpinf1 | gene expression | Serpinf1 | 0.35 | 1 | 0.13 | 4.8e-03 | 5.54 | 3.10e-08 | 0.06 | FALSE |
| Eye | LOC102549294 | mRNA stability | LOC102549294 | 0.56 | 15 | 0.05 | 6.2e-02 | -5.51 | 3.59e-08 | 0.24 | FALSE |
| IL | Crk | gene expression | Crk | 0.16 | 5 | 0.05 | 2.5e-02 | 5.29 | 1.24e-07 | 0.45 | FALSE |
| IL | Rap1gap2 | gene expression | Rap1gap2 | 0.89 | 68 | 0.39 | 1.8e-10 | -5.26 | 1.41e-07 | 0.89 | FALSE |
| IL | Rtn4rl1 | gene expression | Rtn4rl1 | 0.34 | 29 | 0.19 | 2.1e-05 | 5.53 | 3.16e-08 | 0.73 | FALSE |
| IL | Crk | mRNA stability | Crk | 0.22 | 2 | 0.12 | 9.1e-04 | 5.46 | 4.87e-08 | 0.6 | FALSE |
| LHb | Mettl16 | isoform ratio | NM_001402033.1 | 0.53 | 30 | 0.26 | 8.2e-07 | 5.37 | 7.95e-08 | 0.08 | TRUE |
| Liver | Smyd4 | isoform ratio | NM_001105810.1 | 0.02 | 1 | 0.02 | 5.6e-03 | 5.43 | 5.62e-08 | 0.04 | FALSE |
| Liver | Smyd4 | intron excision ratio | chr10_60200371_60201453 | 0.02 | 1 | 0.01 | 1.2e-02 | 5.39 | 6.94e-08 | 0.03 | FALSE |
| Liver | Crk | mRNA stability | Crk | 0.1 | 1 | 0.04 | 6.0e-05 | -5.49 | 3.97e-08 | 0.64 | FALSE |
| NAcc | Doc2b | gene expression | Doc2b | 0.49 | 1 | 0.39 | 1.7e-48 | -5.53 | 3.19e-08 | 0.87 | FALSE |
| NAcc | Smyd4 | intron excision ratio | chr10_60200371_60201453 | 0.09 | 164 | 0.09 | 3.5e-10 | 5.57 | 2.56e-08 | 0.65 | FALSE |
| NAcc | Crk | mRNA stability | Crk | 0.22 | 20 | 0.21 | 2.9e-24 | 5.38 | 7.42e-08 | 0.82 | FALSE |
| NAcc | Doc2b | mRNA stability | Doc2b | 0.04 | 1286 | 0.03 | 4.8e-04 | -5.26 | 1.45e-07 | 0.78 | FALSE |
| OFC | Rph3al | gene expression | Rph3al | 0.25 | 48 | 0.17 | 6.6e-05 | -5.36 | 8.55e-08 | 0.78 | FALSE |
| OFC | Serpinf1 | gene expression | Serpinf1 | 0.15 | 922 | 0.1 | 2.4e-03 | -5.42 | 5.99e-08 | 0.65 | FALSE |
| PL | Crk | gene expression | Crk | 0.22 | 1179 | 0.22 | 1.3e-23 | 5.29 | 1.21e-07 | 0.82 | FALSE |
| PL | Doc2b | gene expression | Doc2b | 0.28 | 1 | 0.17 | 2.1e-18 | -5.53 | 3.19e-08 | 0.87 | FALSE |
| PL | Inpp5k | isoform ratio | NM_001013859.1 | 0.05 | 135 | 0.03 | 2.0e-04 | -5.5 | 3.84e-08 | 0.78 | FALSE |
| PL | Inpp5k | isoform ratio | XM_039085519.1 | 0.04 | 69 | 0.03 | 3.3e-04 | 5.48 | 4.23e-08 | 0.76 | FALSE |
| PL | Ccdc92b | mRNA stability | Ccdc92b | 0.03 | 3 | 0.03 | 2.0e-04 | 5.39 | 7.16e-08 | 0.68 | FALSE |
| PL | Crk | mRNA stability | Crk | 0.26 | 10 | 0.29 | 1.9e-32 | 5.41 | 6.20e-08 | 0.82 | FALSE |
| PL | Myo1c | mRNA stability | Myo1c | 0.03 | 1 | 0.02 | 3.4e-03 | 5.5 | 3.91e-08 | 0.07 | FALSE |
| pVTA | Rph3al | alternative TSS | XM_008767941.3 | 0.19 | 1 | 0.1 | 5.4e-05 | -5.5 | 3.91e-08 | 0.24 | FALSE |
| pVTA | Smyd4 | intron excision ratio | chr10_60200371_60201453 | 0.12 | 1 | 0.09 | 9.2e-05 | -5.5 | 3.76e-08 | 0.76 | FALSE |
| RMTg | Crk | gene expression | Crk | 0.18 | 13 | 0.11 | 6.7e-04 | 5.49 | 3.97e-08 | 0.61 | FALSE |