Best TWAS P=4.408588e-09 · Best GWAS P=3.371323e-07 conditioned to 0.3900322
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pecam1 | gene expression | ENSRNOG00000066008 | 0.08 | 0.05 | enet | 66 | 0.05 | 3.6e-06 | 3.6 | 5.4 | 5.2e-08 | 0.20 | 0.41 | 0.53 | FALSE |
| 2 | Adipose | Ace | mRNA stability | ENSRNOG00000062101 | 0.17 | 0.11 | enet | 32 | 0.12 | 3.8e-13 | 4.8 | -5.3 | 9.7e-08 | -0.66 | 0.22 | 0.78 | FALSE |
| 3 | Brain | Dcaf7 | mRNA stability | ENSRNOG00000042245 | 0.06 | 0.03 | lasso | 12 | 0.04 | 1.5e-04 | 3.6 | -5.2 | 1.7e-07 | -0.82 | 0.33 | 0.63 | FALSE |
| 4 | Liver | Map3k3 | gene expression | ENSRNOG00000061424 | 0.03 | 0.00 | blup | 1859 | 0.01 | 1.1e-02 | 3.9 | 5.9 | 4.4e-09 | 0.78 | 0.38 | 0.48 | TRUE |
| 5 | Liver | Ddx42 | mRNA stability | ENSRNOG00000009474 | 0.04 | 0.01 | blup | 2012 | 0.01 | 9.5e-03 | 4.1 | 5.5 | 3.9e-08 | 0.63 | 0.19 | 0.70 | FALSE |
| 6 | NAcc2 | Ace | isoform ratio | ENSRNOT00000119881 | 0.11 | 0.03 | enet | 15 | 0.06 | 4.2e-04 | 4.7 | -5.3 | 9.9e-08 | -0.48 | 0.23 | 0.63 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.