Hub : Genes

Lbhd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr6:130442448:130444051	0.12	0.08	1.7e-08	0.2	0.13	0.12	0.16	5.6e-11	1.2e-07	4.8e-07	8.5e-09
2	BLA	intron excision ratio	chr6:130442458:130444051	0.05	0.04	2.4e-03	0.01	0.01	-0	0.01	6.5e-02	5.0e-02	3.4e-01	6.5e-02
3	Brain	gene expression	ENSRNOG00000043137	0.05	0.05	5.8e-04	0.03	0.03	0.02	0.03	1.2e-03	8.4e-04	3.1e-03	1.2e-03
4	Brain	intron excision ratio	chr6:130442448:130444051	0.71	0.07	0.0e+00	0.17	0.22	0.23	0.23	8.8e-16	4.2e-20	5.4e-21	7.6e-21
5	PL	intron excision ratio	chr6:130442448:130444051	0.17	0.18	1.1e-05	0.07	0.07	0.07	0.06	6.0e-06	6.6e-06	4.4e-06	1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	2.6	8.5	9.7	3.0	-2.7	-2.9	3.1	2.8
BMI without tail	0.5	1.0	1.4	0.8	-0.9	-1.0	1.2	0.9
Body weight	0.1	0.3	0.5	-0.5	0.7	0.6	-0.6	-0.5
Epididymis fat weight	4.9	11.3	12.4	3.3	-3.3	-3.3	3.5	3.4
Glucose	0.7	1.1	1.5	-0.8	1.1	1.1	-1.2	-1.1
Heart weight	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.3
Left kidney weight	0.6	1.6	2.2	-1.5	1.3	1.2	-1.4	-0.9
Right kidney weight	0.3	0.7	1.1	-1.1	0.8	0.7	-1.0	-0.5
Tail length	3.4	10.2	11.5	-3.4	3.1	3.1	-3.3	-3.0
Length with tail	4.2	15.4	17.6	-4.0	3.9	3.9	-4.2	-3.7
Length without tail	1.6	3.5	4.5	-1.7	1.9	1.8	-2.1	-1.8
Liver weight, left	3.7	6.1	6.9	-2.6	2.4	2.4	-2.5	-2.3
Liver weight, right	0.0	0.0	0.0	-0.2	0.1	0.0	-0.1	0.0
Parametrial fat weight	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	-0.1
Retroperitoneal fat weight	0.2	0.6	0.8	0.7	-0.7	-0.8	0.9	0.9
Intraocular pressure	0.1	0.1	0.1	0.4	-0.3	-0.3	0.3	0.2
Extensor digitorum longus weight	6.0	24.2	27.0	-4.8	4.9	4.9	-5.2	-4.8
Soleus weight	0.0	0.1	0.1	0.1	-0.2	-0.2	0.2	0.3
Tibialis anterior weight	0.3	1.1	1.2	-1.1	1.1	1.0	-1.1	-1.1
Tibia length	0.6	1.7	2.2	-1.5	1.2	1.3	-1.2	-1.3
Number of licking bursts	0.1	0.2	0.4	-0.6	0.4	0.4	-0.3	-0.4
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.2	0.4	0.4	-0.4	-0.5
Times rat made contact with spout	0.2	0.3	0.4	-0.2	0.6	0.5	-0.6	-0.6
Mean time between licks in bursts	0.9	1.3	1.6	1.0	-1.2	-1.1	1.3	1.1
Mean num. licks in bursts	0.0	0.0	0.2	0.4	-0.1	-0.0	0.0	0.0
Std. dev. time between licks in bursts	0.6	0.7	1.0	0.6	-0.9	-0.9	1.0	0.8
Water consumed over 24 hours	3.0	3.5	4.2	-1.4	2.0	1.9	-2.0	-2.0
Indifference point 0 sec	2.9	4.7	6.0	-2.1	2.2	2.1	-2.4	-2.0
Indifference point AUC	2.4	2.8	3.2	-1.4	1.7	1.7	-1.8	-1.8
Indifference point function ln k	0.6	0.9	1.4	-1.2	0.8	0.8	-0.9	-0.9
Indifference point function log k	0.6	0.9	1.4	-1.2	0.8	0.8	-0.9	-0.9
Delay discounting total patch changes 0 sec	3.1	5.0	6.5	-2.1	2.3	2.2	-2.6	-2.0
Delay discounting total patch changes 12 sec	3.0	4.0	5.1	-1.7	2.1	2.0	-2.3	-2.0
Delay discounting total patch changes 18 sec	1.0	1.4	2.0	-0.9	1.2	1.1	-1.4	-1.2
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	0.1	0.4	0.3	-0.4	-0.2
Delay discounting total patch changes 6 sec	1.6	2.4	3.1	-1.3	1.7	1.5	-1.8	-1.4
Delay discounting time to switch 0 sec	11.5	17.5	19.9	4.2	-4.1	-4.2	4.5	4.0
Delay discounting water rate 0 sec	18.7	29.8	34.7	-5.2	5.5	5.4	-5.9	-5.3
Delay discounting water rate 12 sec	9.8	14.7	16.2	-3.8	3.9	3.8	-4.0	-3.6
Delay discounting water rate 18 sec	5.3	7.0	8.0	-2.7	2.6	2.6	-2.8	-2.5
Delay discounting water rate 24 sec	4.2	5.8	6.3	-2.3	2.4	2.5	-2.5	-2.4
Delay discounting water rate 6 sec	4.8	7.0	8.1	-2.7	2.6	2.6	-2.8	-2.5
Locomotor activity	0.0	0.1	0.1	-0.2	0.2	0.2	-0.4	0.0
Locomotor testing distance	0.2	0.3	0.5	-0.5	0.5	0.6	-0.7	-0.4
Locomotor testing rearing	1.7	2.7	3.0	1.7	-1.6	-1.6	1.6	1.6
Light reinforcement 1	0.0	0.1	0.2	0.5	-0.2	-0.2	0.2	0.3
Light reinforcement 2	1.3	1.7	2.4	1.2	-1.3	-1.2	1.5	1.2
Reaction time number correct	2.8	4.0	5.1	-1.9	2.0	1.9	-2.3	-1.9
Reaction time mean minus median	0.1	0.1	0.1	-0.0	-0.3	-0.3	0.3	0.4
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3	0.3
Reaction time num false alarms	0.6	0.8	1.3	-0.7	1.0	0.9	-1.1	-0.8
Reaction time num false alarms AUC	1.2	1.6	2.2	-1.1	1.3	1.3	-1.5	-1.1
Reaction time trials correct on left	2.8	4.0	5.1	-1.9	2.0	1.9	-2.3	-1.9
Reaction time trials on left	2.8	4.0	5.1	-2.0	2.0	1.9	-2.3	-1.9
Reaction time mean	0.8	1.1	1.5	0.6	-1.1	-1.1	1.1	1.2
Reaction time mean AUC	0.5	0.7	1.0	0.4	-0.8	-0.9	0.9	1.0
Median of all reaction times	0.6	0.8	1.1	0.5	-0.9	-0.9	0.9	1.1
Reaction time omissions	1.2	1.6	2.3	-1.5	1.2	1.2	-1.3	-1.1
Reaction time false alarm rate	0.1	0.1	0.1	-0.2	0.3	0.3	-0.4	-0.2
Reaction time premature initiation rate	0.7	1.0	1.1	-0.8	1.0	1.0	-1.1	-1.1
Reaction time premature initiations	2.3	3.3	4.0	-1.7	1.8	1.7	-2.0	-1.8
Std. dev. reaction times	0.2	0.3	0.4	0.1	-0.6	-0.6	0.7	0.6
Reaction time trials completed	2.8	4.0	5.1	-2.0	2.0	1.9	-2.3	-1.9
Reaction time trials AUC	3.0	4.3	5.5	-2.0	2.1	2.0	-2.3	-1.9
Social response proportion	0.2	0.2	0.4	-0.4	0.5	0.4	-0.6	-0.4
Social responses	0.1	0.1	0.3	0.6	-0.3	-0.3	0.3	0.3
Social time	0.9	1.2	1.4	-1.2	1.1	1.0	-1.1	-1.1
Conditioned locomotion	1.2	1.5	1.8	-1.3	1.1	1.1	-1.3	-1.1
Cocaine response after cond. corrected	0.4	0.4	0.5	0.2	-0.7	-0.7	0.7	0.7
Cocaine response after cond. not corrected	1.7	1.9	2.3	1.2	-1.4	-1.4	1.5	1.4
Cocaine response before conditioning	3.0	3.6	4.9	2.2	-1.8	-1.8	1.9	1.8
Saline control response	0.2	0.2	0.3	0.3	-0.6	-0.5	0.6	0.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	-0.5	0.7	0.6	-0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	-0.5	0.7	0.6	-0.7	-0.7
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Condit. Reinf. inactive responses	0.6	0.8	1.0	0.6	-0.9	-0.9	0.9	1.0
Condit. Reinf. lever presses	1.7	2.3	2.8	1.5	-1.5	-1.5	1.7	1.4
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1	0.1
Pavlov. Cond. lever latency	2.2	2.9	3.6	-1.6	1.8	1.7	-1.9	-1.6
Pavlov. Cond. magazine entry latency	5.4	6.2	6.9	2.4	-2.4	-2.5	2.6	2.5
Pavlov. Cond. change in total contacts	4.2	5.9	6.7	2.2	-2.5	-2.5	2.6	2.4
Pavlov. Cond. index score	5.4	7.1	8.1	2.6	-2.6	-2.6	2.8	2.6
Pavlov. Cond. latency score	5.3	6.7	7.6	2.5	-2.6	-2.6	2.8	2.5
Pavlov. Cond. lever contacts	2.8	3.9	5.0	1.8	-2.0	-2.0	2.2	1.8
Pavlov. Cond. magazine entry number	4.4	5.4	5.9	-2.2	2.3	2.4	-2.4	-2.4
Pavlov. Cond. intertrial magazine entries	5.0	6.5	7.8	-2.3	2.5	2.5	-2.8	-2.5
Pavlov. Cond. lever-magazine prob. diff.	6.1	7.9	8.9	2.7	-2.8	-2.8	3.0	2.8
Pavlov. Cond. response bias	4.0	5.6	6.6	2.1	-2.4	-2.4	2.6	2.3
Conditioned reinforcement - actives	2.1	2.1	2.4	-1.5	1.4	1.4	-1.6	-1.4
Conditioned reinforcement - inactives	0.3	0.4	0.5	-0.7	0.6	0.6	-0.7	-0.6
Conditioned locomotion	0.8	0.9	1.0	0.9	-1.0	-0.9	1.0	0.9
Intermittent access intake day 1-15 change	1.4	1.4	1.5	1.1	-1.2	-1.1	1.2	1.1
Intermittent access intake escalation	1.6	1.6	1.7	1.3	-1.3	-1.2	1.3	1.2
Intermittent access intake escalation 2	0.1	0.1	0.1	0.2	-0.4	-0.3	0.3	0.2
Intermitt. access day 1 inactive lever presses	2.6	2.8	3.3	-1.6	1.7	1.7	-1.8	-1.6
Intermitt. access day 15 inactive lever presses	0.9	0.9	1.1	-1.1	0.9	0.9	-1.0	-0.9
Intermitt. access escalation Index	0.2	0.2	0.4	-0.2	0.6	0.5	-0.5	-0.4
Intermittent access day 1 total infusions	0.4	0.5	0.6	0.7	-0.7	-0.7	0.7	0.7
Intermittent access day 15 total infusions	2.0	2.3	2.5	1.6	-1.5	-1.5	1.6	1.5
Intermittent access terminal intake (last 3 days)	2.2	2.4	2.7	1.3	-1.6	-1.6	1.6	1.6
Intermittent access total infusions	0.9	1.0	1.0	1.0	-1.0	-1.0	1.0	1.0
Intermittent access day 1 locomotion	1.1	1.1	1.2	1.0	-1.0	-1.0	1.1	1.0
Intermittent access day 15 total locomotion	0.4	0.4	0.4	0.6	-0.6	-0.6	0.6	0.6
Intermittent access total locomotion	0.5	0.6	0.6	0.8	-0.8	-0.7	0.8	0.7
Intermittent access standard deviation	3.6	3.8	4.5	1.8	-2.0	-1.9	2.1	1.9
Cocaine induced anxiety	3.2	3.6	4.0	-1.9	1.9	1.9	-2.0	-1.9
Post-drug Anxiety	2.6	2.9	3.3	-1.7	1.7	1.7	-1.8	-1.7
Baseline Anxiety	1.7	1.8	1.9	1.3	-1.3	-1.3	1.4	1.3
Lifetime Intake	0.5	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7
Incentive Sensitization - Responses	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	0.0	-0.0	-0.0	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4
Progressive ratio test 1 inactive lever presses	2.9	3.1	3.5	-1.8	1.7	1.7	-1.9	-1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1	-0.2	0.1	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.1	-0.9	0.9	0.9	-1.0	-0.9
Total sessions with >9 infusions	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.4	-0.3	-0.3	0.2	0.4
Short access day 10 total inactive lever presses	0.4	0.4	0.5	-0.6	0.7	0.6	-0.7	-0.6
Short access day 1 total infusions	0.2	0.2	0.2	-0.2	0.4	0.4	-0.5	-0.4
Short access day 10 total infusions	0.5	0.6	0.6	0.7	-0.7	-0.8	0.8	0.8
Short access total infusions	0.3	0.3	0.3	0.6	-0.6	-0.6	0.6	0.5
Short access day 1 locomotion	0.9	0.9	0.9	0.9	-1.0	-1.0	1.0	1.0
Short access day 10 total locomotion	0.7	0.8	0.9	0.9	-0.9	-0.8	0.9	0.9
Short access total locomotion	0.1	0.1	0.1	0.4	-0.3	-0.3	0.3	0.3
Compulsive drug intake	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.3	0.2	0.2	-0.3	-0.2
One hour access (shock baseline)	0.0	0.0	0.0	0.2	-0.2	-0.2	0.1	0.1
Number of responses in last shaping day	0.3	0.3	0.5	0.5	-0.6	-0.6	0.7	0.5
Context. condit. distance diff. score	1.7	2.1	2.4	-1.2	1.4	1.5	-1.6	-1.5
Locomotion velocity, session 1	0.4	0.4	0.6	-0.6	0.6	0.7	-0.5	-0.8
Locomotion distance, session 1	0.3	0.3	0.6	0.6	-0.6	-0.5	0.7	0.3
Locomotion velocity, session 2	0.0	0.0	0.1	0.3	-0.1	-0.2	0.1	0.2
Locomotion distance, session 2	0.3	0.4	0.6	0.6	-0.6	-0.6	0.8	0.5
Locomotion velocity, session 3	0.2	0.3	0.4	0.6	-0.5	-0.5	0.5	0.5
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	0.1	0.2	-0.1	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	0.4	0.4	-0.4	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.4	0.5	0.5	-0.5	-0.5
Locomotion velocity, session 7	0.4	0.5	0.6	0.8	-0.7	-0.7	0.6	0.7
Locomotion distance, session 7	0.8	1.1	1.2	1.1	-1.1	-1.0	1.1	0.9
Stereotopy head waving bouts, day 7	0.9	1.0	1.2	-1.1	1.0	1.0	-1.1	-0.9
Stereotopy head waving duration, day 7	0.3	0.3	0.4	-0.6	0.6	0.5	-0.7	-0.5
Locomotion velocity, session 8	0.1	0.1	0.2	-0.3	0.4	0.4	-0.4	-0.4
Locomotion distance, session 8	0.0	0.0	0.1	0.2	-0.2	-0.0	0.2	-0.0
Degree of sensitization distance	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4	0.3
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.6	0.4	0.5	-0.5	-0.4
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	0.7	-0.7	-0.7	0.9	0.7
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.2	1.6	-1.6	-1.6	1.8	1.5
Condit. Reinf. active responses	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.4
Condit. Reinf. inactive responses	1.9	2.2	2.6	-1.4	1.5	1.5	-1.6	-1.5
Incentive salience index mean	0.4	0.5	0.7	0.8	-0.7	-0.7	0.8	0.6
Condit. Reinf. lever presses	0.1	0.2	0.3	0.6	-0.4	-0.4	0.4	0.3
Time in familiar zone, hab. session 1	0.9	0.8	1.0	1.0	-0.9	-0.9	0.8	0.9
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.2	0.1
Total zone transitions, hab. session 1	0.6	0.8	1.0	0.9	-0.9	-0.8	1.0	0.8
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.2	-0.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.6	0.6	-0.7	0.7	0.8	-0.8	-0.7
Time in familiar zone, hab. session 2	1.0	1.0	1.3	1.2	-0.9	-1.0	0.9	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.3	0.0	0.1	0.1	-0.0
Total zone transitions, hab. session 2	0.6	0.7	1.1	0.8	-0.9	-0.8	1.0	0.7
Total locomotion distance, hab. session 2	0.5	0.7	0.8	-0.9	0.7	0.8	-0.8	-0.9
Locomotion velocity, hab. session 2	0.7	1.0	1.1	-1.0	0.9	1.0	-0.9	-1.0
Novel to familiar place preference ratio	0.2	0.2	0.3	0.3	-0.5	-0.5	0.6	0.5
Novelty place preference	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4
Time in novel zone, NPP test	0.1	0.1	0.1	0.2	-0.3	-0.3	0.4	0.3
Total zone transitions, NPP test	0.1	0.1	0.2	0.2	-0.3	-0.3	0.5	0.2
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.5	0.2	0.3	-0.2	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.5	0.3	0.4	-0.3	-0.4
Pavlov. Cond. lever latency	0.7	0.9	1.1	-1.0	0.9	0.9	-1.0	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	0.9	0.9	-0.8	-0.8	0.9	0.7
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	0.8	-0.6	-0.6	0.6	0.6
Pavlov. Cond. index score	0.9	1.2	1.4	1.1	-1.1	-1.1	1.2	1.0
Pavlov. Cond. latency score	0.6	0.7	0.9	0.9	-0.9	-0.8	1.0	0.8
Pavlov. Cond. lever contacts	0.9	1.1	1.2	1.0	-1.0	-1.0	1.1	1.0
Pavlov. Cond. magazine entry number	1.1	1.4	1.6	-1.2	1.2	1.2	-1.3	-1.1
Pavlov. Cond. intertrial magazine entries	5.7	6.9	7.6	-2.6	2.6	2.6	-2.8	-2.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	0.9	-0.9	-0.8	1.0	0.8
Pavlov. Cond. response bias	1.3	1.6	1.8	1.3	-1.3	-1.2	1.3	1.2
Bone: apparent density	0.0	0.1	0.1	0.2	-0.3	-0.2	0.2	0.2
Bone surface	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.0
Bone volume	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1
Bone: connectivity density	0.0	0.0	0.1	-0.1	0.2	0.2	-0.3	-0.1
Bone: cortical apparent density	8.5	11.1	13.5	-3.1	3.4	3.3	-3.7	-3.2
Bone: cortical area	1.5	2.3	2.7	-1.6	1.4	1.5	-1.4	-1.6
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0	0.1
Bone: cortical porosity	0.2	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5
Bone: cortical thickness	1.4	2.3	2.6	-1.6	1.3	1.5	-1.5	-1.6
Bone: cortical thickness	1.1	1.3	1.6	-1.2	1.0	1.2	-1.1	-1.2
Bone: cortical tissue density	8.6	11.2	13.6	-3.1	3.4	3.3	-3.7	-3.2
Bone: elastic displacement	0.8	0.9	1.1	-1.0	0.8	0.9	-0.9	-0.9
Bone: elastic work	0.2	0.3	0.4	-0.7	0.5	0.6	-0.4	-0.7
Bone: endosteal estimation	0.2	0.3	0.6	0.6	-0.5	-0.6	0.8	0.4
Bone: endosteal perimeter	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.3
Bone: final force	0.5	0.8	1.1	-1.0	0.7	0.9	-0.8	-1.0
Bone: final moment	0.6	1.0	1.3	-1.1	0.8	1.0	-0.8	-1.1
Bone: marrow area	0.1	0.3	0.5	0.5	-0.5	-0.5	0.7	0.3
Bone: maximum diameter	0.1	0.3	0.4	-0.6	0.4	0.5	-0.3	-0.6
Bone: maximum force	0.5	0.8	1.1	-1.0	0.8	0.9	-0.8	-1.1
Bone: maximum moment	0.5	0.8	1.1	-1.0	0.8	0.9	-0.8	-1.1
Bone: minimum diameter	0.8	1.4	1.6	-1.2	1.2	1.2	-1.1	-1.3
Bone: periosteal estimation	0.2	0.5	0.7	-0.7	0.6	0.7	-0.4	-0.8
Bone: periosteal perimeter	0.2	0.3	0.5	-0.7	0.4	0.5	-0.3	-0.6
Bone: post-yield work	1.1	1.5	1.7	-1.3	1.2	1.2	-1.3	-1.2
Bone: stiffness	2.0	3.2	3.6	-1.9	1.7	1.8	-1.7	-1.9
Bone: tissue strength	0.2	0.2	0.3	-0.5	0.4	0.5	-0.3	-0.5
Bone: trabecular number	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2	-0.0
Bone: trabecular spacing	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	0.1
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	0.4	0.4	-0.4	-0.4
Bone: trabecular tissue density	0.1	0.2	0.3	-0.2	0.5	0.4	-0.6	-0.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.3	-0.1	-0.0	0.2	-0.0
Distance traveled before self-admin	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.3
Distance traveled after self-admin	0.5	0.6	0.8	-0.7	0.7	0.8	-0.9	-0.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	0.3
Delta time in open arm before/after self-admin	0.4	0.4	0.5	-0.6	0.7	0.6	-0.6	-0.7
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.6	0.1	0.1	-0.2	-0.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.0	-0.1	-0.0	0.0	0.0
Active lever presses in extinction session 6	1.3	1.2	1.4	-1.0	1.1	1.1	-1.2	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.2	0.1	0.2	-0.2	-0.2
Delta ambulatory time before/after self-admin	0.5	0.5	0.7	-0.5	0.7	0.8	-0.8	-0.8
Time in closed arm before self-admin	3.1	3.5	3.9	1.9	-1.8	-1.8	2.0	1.8
Time in closed arm after self-admin	1.6	1.7	1.8	1.1	-1.3	-1.4	1.3	1.4
Time in open arm before self-admin	5.3	5.7	6.8	-2.3	2.3	2.3	-2.6	-2.3
Time in open arm after self-admin	3.1	3.4	3.9	-1.7	1.9	1.8	-2.0	-1.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.1	1.1	-0.5	-0.4	0.6	0.4
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.7	-0.6	0.8	0.8	-0.8	-0.8
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.5	-0.5	-0.5	0.4	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.3
Time to tail flick, test, after self-admin	1.9	1.9	2.3	-1.4	1.4	1.3	-1.5	-1.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	0.3
Delta time to tail flick, test, before/after SA	1.2	1.0	1.3	-1.1	1.0	1.0	-1.1	-0.9
Ambulatory time before self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.2	0.4
Ambulatory time after self-admin	0.0	0.0	0.0	0.2	-0.1	-0.1	0.0	0.1
Total heroin consumption	1.2	1.4	1.7	-0.9	1.2	1.2	-1.2	-1.3
Area under the delay curve	0.2	0.2	0.4	0.6	-0.2	-0.4	0.4	0.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	0.3	0.2	-0.2	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.6	-0.1	-0.3	0.2	0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.5	-0.2	-0.2	0.3	0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2	0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.1	0.3	0.2	-0.3	-0.2
Delay disc. indifference point, 8s delay	0.4	0.4	0.7	0.8	-0.4	-0.6	0.6	0.6
Delay discount exponential model param	0.1	0.1	0.3	-0.6	0.2	0.3	-0.3	-0.3
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.6	0.2	0.4	-0.3	-0.3
Fecal boli incidents, locomotor time 1	1.4	1.5	2.3	1.2	-1.2	-1.2	1.5	1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.6	0.7	-0.7	-0.7	0.8	0.6
Bouts of movement, locomotor time 1	0.9	1.0	1.5	1.1	-1.0	-1.0	1.2	0.7
Total resting periods, locomotor time 1	1.0	1.1	1.5	1.1	-1.1	-1.0	1.2	0.8
Rest time, locomotor task time 1	0.4	0.4	0.5	-0.7	0.6	0.5	-0.6	-0.7
Distance moved, locomotor task time 1	0.6	0.7	0.9	1.0	-0.8	-0.7	0.7	0.9
Vertical activity count, locomotor time 1	0.4	0.4	0.6	-0.3	0.7	0.7	-0.8	-0.6
Time >=10cm from walls, locomotor time 2	0.7	0.7	0.9	-0.9	0.7	0.8	-0.8	-1.0
Bouts of movement, locomotor time 2	2.5	2.7	3.2	-1.6	1.6	1.6	-1.6	-1.8
Total resting periods, locomotor time 2	1.8	2.0	2.2	-1.4	1.4	1.4	-1.4	-1.5
Rest time, locomotor task time 2	0.5	0.5	0.6	-0.8	0.8	0.7	-0.7	-0.6
Distance moved, locomotor task time 2	0.4	0.5	0.8	0.9	-0.7	-0.6	0.6	0.6
Vertical activity count, locomotor time 2	0.4	0.5	0.7	-0.6	0.6	0.7	-0.8	-0.8
Weight adjusted by age	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	-0.2	0.6	0.6	-0.6	-0.9
Locomotion in novel chamber	5.5	6.8	7.7	-2.6	2.6	2.6	-2.8	-2.4
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2	0.1
Progressive ratio	0.4	0.5	0.6	-0.5	0.7	0.8	-0.7	-0.7
Food seeking constrained by brief footshock	2.2	2.7	2.9	-1.7	1.5	1.6	-1.6	-1.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.5	0.3	0.3	-0.3	-0.4
Run reversals in cocaine runway, females	1.1	1.1	1.2	1.0	-1.0	-1.1	1.1	1.1
Run reversals in cocaine runway, males	1.1	1.1	1.3	-1.2	1.0	1.0	-1.1	-1.0
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.6	-0.4	-0.5	0.4	0.5
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	0.7	-0.4	-0.5	0.4	0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3	0.4
Cd content in liver	0.5	0.6	0.7	-0.8	0.7	0.8	-0.7	-0.8
Co content in liver	0.9	1.0	1.4	-1.2	0.9	1.0	-1.0	-1.0
Cu content in liver	0.9	1.1	1.4	1.0	-1.0	-1.1	1.2	1.1
Fe content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3	0.4	0.4
K content in liver	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.2
Mg content in liver	0.0	0.0	0.1	-0.1	0.2	0.1	-0.3	-0.1
Mn content in liver	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.1	-0.1
Na content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	0.1
Rb content in liver	0.6	0.7	0.9	-0.9	0.8	0.8	-1.0	-0.7
Se content in liver	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.3	0.1
Sr content in liver	0.5	0.4	0.5	-0.7	0.6	0.7	-0.6	-0.7
Zn content in liver	0.3	0.3	0.3	-0.5	0.5	0.5	-0.5	-0.6