Hub : Genes

Khdc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000054460 0.06 0.04 4.6e-05 0.03 0.03 0.02 0.03 1.1e-04 2.8e-04 1.4e-03 6.1e-04
2 BLA gene expression ENSRNOG00000054460 0.1 0.06 1.2e-04 0.06 0.01 0.01 0.02 6.4e-04 7.8e-02 6.0e-02 1.8e-02
3 Brain gene expression ENSRNOG00000054460 0.04 0.02 2.0e-04 0.05 0.04 0.03 0.04 2.1e-05 1.8e-04 2.1e-03 6.4e-05
4 PL gene expression ENSRNOG00000054460 0.11 0.06 5.1e-07 0.06 0.07 0.08 0.08 1.9e-05 4.4e-06 8.1e-07 1.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail5.417.420.74.04.14.64.0
BMI without tail1.32.75.11.21.21.62.3
Body weight2.811.915.23.33.33.93.2
Epididymis fat weight0.51.12.0-1.3-1.4-0.6-0.5
Glucose0.71.01.31.11.00.81.1
Heart weight0.20.20.60.0-0.20.80.6
Left kidney weight2.05.68.42.01.92.92.6
Right kidney weight0.92.63.51.41.41.91.7
Tail length0.41.42.2-1.3-1.5-1.2-0.4
Length with tail0.10.30.50.40.30.70.6
Length without tail2.65.67.72.52.52.81.5
Liver weight, left0.91.52.21.11.21.11.5
Liver weight, right2.03.34.11.82.01.42.0
Parametrial fat weight0.51.01.9-1.4-1.2-0.7-0.5
Retroperitoneal fat weight0.20.71.4-1.1-1.2-0.20.0
Intraocular pressure0.20.30.6-0.8-0.80.10.0
Extensor digitorum longus weight6.325.228.44.94.75.15.3
Soleus weight14.141.243.46.46.36.36.6
Tibialis anterior weight14.449.851.47.07.07.17.2
Tibia length0.20.61.10.91.00.7-0.2
Number of licking bursts2.02.33.0-1.6-1.4-1.7-1.4
Food consumed during 24 hour testing period1.92.32.81.71.71.41.3
Times rat made contact with spout0.00.00.1-0.3-0.30.1-0.0
Mean time between licks in bursts0.60.81.1-0.8-0.9-1.0-1.0
Mean num. licks in bursts2.12.53.81.61.31.91.5
Std. dev. time between licks in bursts0.00.00.0-0.1-0.0-0.00.2
Water consumed over 24 hours0.10.10.2-0.0-0.1-0.2-0.4
Indifference point 0 sec0.10.10.30.00.30.50.4
Indifference point AUC1.82.13.1-1.2-1.5-1.8-1.2
Indifference point function ln k2.43.33.91.72.02.01.6
Indifference point function log k2.43.33.91.72.02.01.6
Delay discounting total patch changes 0 sec0.20.30.60.10.40.80.6
Delay discounting total patch changes 12 sec0.71.01.4-1.2-1.2-0.9-0.6
Delay discounting total patch changes 18 sec0.10.10.3-0.5-0.5-0.2-0.2
Delay discounting total patch changes 24 sec0.70.91.6-1.2-1.3-0.7-0.3
Delay discounting total patch changes 6 sec0.30.50.9-1.0-0.8-0.6-0.1
Delay discounting time to switch 0 sec0.40.71.2-0.5-0.6-0.9-1.1
Delay discounting water rate 0 sec1.82.94.11.51.52.01.8
Delay discounting water rate 12 sec2.94.47.41.41.32.62.7
Delay discounting water rate 18 sec0.30.51.00.20.21.00.9
Delay discounting water rate 24 sec0.20.30.5-0.7-0.7-0.40.1
Delay discounting water rate 6 sec0.40.61.00.50.50.91.0
Locomotor activity5.28.210.12.72.93.22.7
Locomotor testing distance3.45.77.62.02.42.82.3
Locomotor testing rearing0.81.21.60.81.11.21.3
Light reinforcement 11.22.32.91.41.41.71.5
Light reinforcement 20.10.10.5-0.0-0.1-0.1-0.7
Reaction time number correct1.42.02.91.01.31.51.7
Reaction time mean minus median0.30.40.6-0.5-0.6-0.6-0.8
Reaction time mean minus median AUC0.81.01.1-1.0-1.0-1.0-1.0
Reaction time num false alarms0.20.20.3-0.5-0.5-0.4-0.3
Reaction time num false alarms AUC0.00.10.1-0.3-0.30.10.3
Reaction time trials correct on left1.42.02.91.01.31.51.7
Reaction time trials on left1.41.92.81.01.31.51.7
Reaction time mean2.23.04.6-1.4-1.5-1.8-2.1
Reaction time mean AUC2.23.04.6-1.3-1.4-1.9-2.1
Median of all reaction times2.73.75.7-1.5-1.6-2.0-2.4
Reaction time omissions0.00.00.1-0.2-0.3-0.2-0.1
Reaction time false alarm rate0.60.91.2-0.9-1.1-0.9-0.8
Reaction time premature initiation rate0.71.01.31.01.10.61.1
Reaction time premature initiations1.82.63.61.41.71.41.9
Std. dev. reaction times1.62.22.7-1.3-1.5-1.4-1.6
Reaction time trials completed1.41.92.81.01.31.51.7
Reaction time trials AUC1.21.72.61.01.21.41.6
Social response proportion1.31.42.51.51.60.70.5
Social responses0.10.10.20.30.30.30.4
Social time0.60.71.00.91.00.80.7
Conditioned locomotion0.00.00.1-0.10.10.2-0.2
Cocaine response after cond. corrected6.87.68.92.82.73.02.5
Cocaine response after cond. not corrected5.56.17.02.62.52.62.1
Cocaine response before conditioning1.01.21.8-0.9-0.9-1.3-1.3
Saline control response0.10.10.2-0.20.20.30.4
Condit. Reinf. active minus inactive responses2.22.73.11.61.61.61.8
Condit. Reinf. active-inactive response ratio2.52.63.11.61.61.71.5
Condit. Reinf. active responses1.01.41.61.11.21.11.2
Condit. Reinf. inactive responses0.60.81.1-1.1-0.8-1.0-0.7
Condit. Reinf. lever presses0.10.10.3-0.00.2-0.2-0.5
Condit. Reinf. lever reinforcers received0.71.01.20.91.11.00.9
Pavlov. Cond. lever latency0.60.81.20.80.71.01.1
Pavlov. Cond. magazine entry latency4.55.15.5-2.3-2.3-2.1-2.3
Pavlov. Cond. change in total contacts1.31.82.3-1.5-1.4-1.1-1.2
Pavlov. Cond. index score1.82.32.6-1.6-1.5-1.5-1.5
Pavlov. Cond. latency score1.21.51.8-1.4-1.2-1.1-1.3
Pavlov. Cond. lever contacts0.40.60.9-0.6-0.5-0.8-1.0
Pavlov. Cond. magazine entry number3.64.44.52.12.12.12.0
Pavlov. Cond. intertrial magazine entries1.11.41.71.11.21.11.3
Pavlov. Cond. lever-magazine prob. diff.2.12.73.0-1.7-1.5-1.6-1.7
Pavlov. Cond. response bias1.92.63.2-1.5-1.5-1.7-1.8
Conditioned reinforcement - actives0.00.00.10.20.30.20.2
Conditioned reinforcement - inactives0.10.10.3-0.2-0.20.60.4
Conditioned locomotion0.20.20.70.10.0-0.3-0.8
Intermittent access intake day 1-15 change0.50.51.0-1.0-1.0-0.20.3
Intermittent access intake escalation0.20.10.2-0.4-0.4-0.40.2
Intermittent access intake escalation 20.10.10.20.20.20.30.5
Intermitt. access day 1 inactive lever presses0.00.00.10.00.1-0.1-0.2
Intermitt. access day 15 inactive lever presses0.10.10.1-0.4-0.4-0.1-0.3
Intermitt. access escalation Index0.40.41.40.20.21.20.2
Intermittent access day 1 total infusions0.10.10.20.00.00.0-0.5
Intermittent access day 15 total infusions0.10.10.2-0.3-0.3-0.4-0.4
Intermittent access terminal intake (last 3 days)0.10.10.20.10.1-0.2-0.5
Intermittent access total infusions0.00.00.10.30.20.2-0.1
Intermittent access day 1 locomotion0.30.31.0-0.1-0.2-0.6-1.0
Intermittent access day 15 total locomotion0.10.10.50.20.10.0-0.7
Intermittent access total locomotion0.20.20.40.60.50.50.0
Intermittent access standard deviation0.10.10.1-0.3-0.3-0.3-0.4
Cocaine induced anxiety0.40.50.9-0.4-0.4-0.9-0.8
Post-drug Anxiety3.03.45.5-1.6-1.6-2.4-1.6
Baseline Anxiety1.21.31.7-1.3-1.3-1.1-0.8
Lifetime Intake0.00.00.10.10.0-0.0-0.3
Incentive Sensitization - Responses1.81.82.91.21.21.71.2
Incentive Sensitization - Breakpoint1.31.42.41.01.01.51.0
Progressive ratio test 1 active lever presses0.50.50.50.70.70.70.7
Progressive ratio test 1 breakpoint0.20.20.30.50.50.30.3
Progressive ratio test 1 inactive lever presses0.00.00.10.10.1-0.3-0.1
Progressive ratio test 2 active lever presses1.11.11.41.11.01.21.0
Progressive ratio test 2 breakpoint1.21.42.21.01.01.51.1
Progressive ratio test 2 inactive lever presses0.00.00.1-0.1-0.00.2-0.4
Total sessions with >9 infusions0.60.71.01.01.00.30.9
Short access day 1 total inactive lever presses1.21.42.10.90.81.41.4
Short access day 10 total inactive lever presses0.10.20.2-0.4-0.5-0.2-0.5
Short access day 1 total infusions0.10.10.20.50.40.3-0.1
Short access day 10 total infusions0.10.10.30.00.0-0.2-0.5
Short access total infusions0.10.10.2-0.0-0.0-0.4-0.5
Short access day 1 locomotion0.50.50.91.00.90.40.4
Short access day 10 total locomotion0.40.40.60.80.70.70.4
Short access total locomotion0.10.10.30.30.2-0.2-0.6
Compulsive drug intake0.40.30.40.50.60.50.7
One hour access (0.3 mA shock)0.30.30.40.60.70.60.3
One hour access (shock baseline)0.10.10.40.20.1-0.1-0.6
Number of responses in last shaping day0.20.20.40.60.60.20.2
Context. condit. distance diff. score0.00.00.10.10.1-0.1-0.3
Locomotion velocity, session 11.01.01.90.70.61.11.4
Locomotion distance, session 10.30.40.7-0.8-0.8-0.6-0.2
Locomotion velocity, session 20.10.10.4-0.4-0.6-0.2-0.1
Locomotion distance, session 20.00.10.1-0.2-0.3-0.10.3
Locomotion velocity, session 30.10.10.1-0.3-0.3-0.20.3
Locomotion distance, session 32.83.03.4-1.7-1.8-1.8-1.5
Stereotopy head waving bouts, day 31.72.12.61.61.61.31.2
Stereotopy head waving duration, day 32.63.23.51.81.91.81.6
Locomotion velocity, session 70.70.71.0-0.7-0.8-1.0-0.9
Locomotion distance, session 71.31.72.1-1.3-1.3-1.5-1.0
Stereotopy head waving bouts, day 70.80.91.70.70.71.01.3
Stereotopy head waving duration, day 71.11.32.21.00.91.11.5
Locomotion velocity, session 80.20.20.60.20.20.20.8
Locomotion distance, session 80.40.60.9-0.8-0.9-1.0-0.5
Degree of sensitization distance0.00.10.1-0.3-0.2-0.2-0.0
Degree of sensitization stereotypy0.60.61.30.50.40.91.1
Condit. Reinf. active minus inactive responses1.61.72.0-1.3-1.3-1.3-1.4
Condit. Reinf. active-inactive response ratio0.50.51.5-0.3-0.3-0.6-1.2
Condit. Reinf. active responses1.31.62.0-1.4-1.4-1.3-0.8
Condit. Reinf. inactive responses0.81.01.5-1.2-1.2-1.00.3
Incentive salience index mean1.11.31.6-1.0-1.0-1.2-1.3
Condit. Reinf. lever presses0.60.81.2-0.7-0.7-1.1-1.0
Time in familiar zone, hab. session 10.10.10.3-0.5-0.4-0.2-0.2
Time in novel zone, hab. session 10.00.00.10.30.30.1-0.0
Total zone transitions, hab. session 11.31.83.4-1.7-1.8-0.7-0.5
Total locomotion distance, hab. session 10.50.71.3-1.2-1.1-0.5-0.0
Locomotion velocity, hab. session 10.20.30.6-0.8-0.8-0.20.2
Time in familiar zone, hab. session 20.20.20.5-0.7-0.6-0.4-0.0
Time in novel zone, hab. session 20.60.61.01.01.00.70.2
Total zone transitions, hab. session 20.50.71.2-1.0-1.1-0.6-0.3
Total locomotion distance, hab. session 20.30.40.8-0.9-0.8-0.40.0
Locomotion velocity, hab. session 20.20.30.6-0.8-0.7-0.4-0.1
Novel to familiar place preference ratio1.01.11.51.21.11.00.8
Novelty place preference1.41.42.11.41.31.10.8
Time in novel zone, NPP test2.02.12.91.71.61.41.1
Total zone transitions, NPP test0.30.51.1-0.9-1.1-0.20.0
Total locomotion distance, NPP test0.20.30.5-0.7-0.7-0.00.5
Locomotion velocity, NPP test0.50.81.5-1.2-1.2-0.50.1
Pavlov. Cond. lever latency0.81.11.31.01.11.00.9
Pavlov. Cond. magazine entry latency4.86.27.4-2.4-2.4-2.4-2.7
Pavlov. Cond. change in total contacts1.11.21.5-0.9-1.0-1.2-1.2
Pavlov. Cond. index score4.05.15.5-2.1-2.2-2.3-2.3
Pavlov. Cond. latency score3.34.24.5-2.0-2.1-2.1-2.0
Pavlov. Cond. lever contacts1.31.51.6-1.1-1.2-1.3-1.3
Pavlov. Cond. magazine entry number4.86.07.12.32.42.42.7
Pavlov. Cond. intertrial magazine entries0.10.20.6-0.3-0.2-0.10.8
Pavlov. Cond. lever-magazine prob. diff.3.64.54.9-2.0-2.1-2.2-2.2
Pavlov. Cond. response bias3.03.74.7-1.7-1.8-1.9-2.2
Bone: apparent density0.20.30.5-0.7-0.7-0.3-0.4
Bone surface0.20.30.50.20.30.70.7
Bone volume0.20.30.60.20.30.80.6
Bone: connectivity density1.72.73.6-1.9-1.9-1.5-1.2
Bone: cortical apparent density0.40.50.6-0.7-0.8-0.7-0.8
Bone: cortical area1.01.52.91.21.21.70.8
Bone: cortical porosity0.60.61.2-0.6-0.8-0.5-1.1
Bone: cortical porosity1.31.42.6-0.9-1.1-1.1-1.6
Bone: cortical thickness0.10.20.5-0.3-0.30.1-0.7
Bone: cortical thickness0.10.10.20.50.2-0.1-0.5
Bone: cortical tissue density0.50.60.7-0.7-0.8-0.8-0.8
Bone: elastic displacement0.10.10.20.40.30.20.2
Bone: elastic work0.00.10.10.30.20.1-0.3
Bone: endosteal estimation2.75.76.12.42.52.42.3
Bone: endosteal perimeter3.67.48.92.62.73.02.6
Bone: final force1.11.72.31.31.31.51.0
Bone: final moment0.91.52.11.31.31.40.9
Bone: marrow area2.96.36.82.52.62.52.4
Bone: maximum diameter3.56.59.02.42.43.02.3
Bone: maximum force1.01.82.61.31.31.61.1
Bone: maximum moment1.01.72.51.31.31.60.9
Bone: minimum diameter0.30.61.30.70.71.10.1
Bone: periosteal estimation2.85.77.02.32.42.62.1
Bone: periosteal perimeter3.15.25.92.32.32.42.1
Bone: post-yield work0.10.10.20.10.10.30.5
Bone: stiffness1.82.83.31.61.71.71.8
Bone: tissue strength0.60.60.9-0.7-0.6-0.8-1.0
Bone: trabecular number1.11.82.5-1.5-1.6-1.2-1.0
Bone: trabecular spacing0.10.10.1-0.1-0.3-0.2-0.4
Bone: trabecular thickness0.40.51.00.30.71.00.6
Bone: trabecular tissue density9.613.518.03.53.54.23.4
Breakpoint value in progressive ratio session0.10.10.20.20.2-0.4-0.1
Distance traveled before self-admin0.40.50.91.00.90.30.1
Distance traveled after self-admin3.43.84.22.02.01.91.8
Delta time in closed arm before/after self-admin0.10.10.20.30.30.50.1
Delta time in open arm before/after self-admin0.90.81.0-1.0-1.0-0.9-0.7
Diff in mean of infusions in LGA sessions0.91.01.91.41.4-0.10.5
Extinction: sum of active levers before priming0.40.40.5-0.6-0.6-0.7-0.6
Active lever presses in extinction session 60.10.10.20.30.3-0.40.0
Delta distance traveled before/after self-admin3.33.54.71.71.71.92.2
Delta ambulatory time before/after self-admin2.42.63.31.41.41.81.8
Time in closed arm before self-admin0.20.30.4-0.4-0.4-0.6-0.6
Time in closed arm after self-admin0.00.00.00.10.10.00.1
Time in open arm before self-admin2.12.22.41.51.51.41.4
Time in open arm after self-admin0.20.20.30.50.50.40.4
Sum of active levers in priming session hrs 5-60.30.30.40.60.60.40.5
Time to tail flick, vehicle, before self-admin1.01.02.2-0.8-0.8-1.5-0.6
Time to tail flick, vehicle, after self-admin1.92.03.21.81.81.00.9
Time to tail flick, test, before self-admin1.31.31.7-1.1-1.1-1.0-1.3
Time to tail flick, test, after self-admin1.31.31.5-1.2-1.2-1.1-1.0
Delta time to tail flick, vehicle, before/after SA1.61.52.21.51.51.20.5
Delta time to tail flick, test, before/after SA0.20.20.30.40.40.60.5
Ambulatory time before self-admin0.10.10.30.20.2-0.4-0.5
Ambulatory time after self-admin3.23.64.32.12.11.71.6
Total heroin consumption0.80.91.70.90.90.51.3
Area under the delay curve0.10.10.1-0.2-0.20.1-0.4
Delay disc. indifference point, 0s delay1.81.92.4-1.4-1.6-1.3-1.3
Delay disc. indifference point, 16s delay0.10.10.3-0.2-0.20.1-0.6
Delay disc. indifference point, 2s delay0.10.10.2-0.5-0.4-0.3-0.3
Delay disc. indifference point, 24s delay0.30.30.6-0.7-0.6-0.2-0.4
Delay disc. indifference point, 4s delay0.50.50.8-0.6-0.7-0.6-0.9
Delay disc. indifference point, 8s delay0.10.10.20.30.30.40.3
Delay discount exponential model param0.00.00.10.20.1-0.20.3
Delay discount hyperbolic model param0.00.10.10.20.2-0.00.4
Fecal boli incidents, locomotor time 10.40.50.9-0.6-0.5-0.5-1.0
Change in fecal boli incidents, locomotor task3.73.54.22.02.01.81.6
Time >=10cm from walls, locomotor time 10.70.71.00.91.00.60.7
Bouts of movement, locomotor time 10.00.00.10.20.40.00.0
Total resting periods, locomotor time 10.00.00.10.10.2-0.0-0.1
Rest time, locomotor task time 10.10.20.5-0.20.0-0.1-0.7
Distance moved, locomotor task time 10.10.10.3-0.3-0.5-0.40.1
Vertical activity count, locomotor time 10.10.10.1-0.1-0.3-0.3-0.2
Time >=10cm from walls, locomotor time 20.00.00.20.00.00.4-0.1
Bouts of movement, locomotor time 20.30.30.70.40.40.60.8
Total resting periods, locomotor time 20.40.40.80.50.50.60.9
Rest time, locomotor task time 20.10.20.3-0.20.1-0.5-0.6
Distance moved, locomotor task time 20.10.10.2-0.4-0.5-0.00.3
Vertical activity count, locomotor time 20.50.60.8-0.9-0.8-0.6-0.8
Weight adjusted by age6.16.97.62.82.72.62.4
Seeking ratio, delayed vs. immediate footshock1.92.13.01.71.71.01.2
Locomotion in novel chamber0.10.10.5-0.0-0.0-0.3-0.7
Locomotion in novel chamber post-restriction0.40.40.5-0.7-0.7-0.6-0.5
Progressive ratio0.70.81.7-0.2-0.1-1.3-1.2
Food seeking constrained by brief footshock0.50.51.00.50.60.81.0
Seeking ratio, punishment vs. effort2.83.55.81.11.12.42.4
Run reversals in cocaine runway, females0.20.20.20.20.40.50.5
Run reversals in cocaine runway, males0.10.10.2-0.4-0.4-0.10.4
Latency to leave start box in cocaine runway1.61.82.01.41.41.41.1
Latency to leave start box in cocaine runway, F0.20.30.30.60.50.40.6
Latency to leave start box in cocaine runway, M2.42.34.71.31.32.21.1
Cd content in liver0.91.01.6-1.3-1.2-0.6-0.5
Co content in liver0.20.30.4-0.5-0.5-0.4-0.7
Cu content in liver0.20.30.50.70.60.50.3
Fe content in liver0.91.01.5-1.0-1.2-1.2-0.5
K content in liver0.70.71.10.60.71.01.0
Mg content in liver2.42.52.61.61.61.61.6
Mn content in liver0.80.91.41.01.20.90.4
Na content in liver1.41.51.71.31.31.11.2
Rb content in liver1.62.03.41.31.11.31.8
Se content in liver0.60.71.1-1.1-1.0-0.7-0.5
Sr content in liver0.90.91.1-1.1-0.9-0.9-0.9
Zn content in liver0.20.30.5-0.4-0.4-0.4-0.7