| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | isoform ratio | ENSRNOT00000019133 | 0.061 | 0.0320 | 1.6e-07 | 0.041 | 0.052 | 0.048 | 0.049 | 2.2e-05 | 1.9e-06 | 4.2e-06 | 3.6e-06 |
| 2 | BLA | gene expression | ENSRNOG00000003899 | 0.148 | 0.0682 | 2.3e-06 | 0.044 | 0.067 | 0.046 | 0.045 | 2.2e-03 | 1.8e-04 | 1.7e-03 | 1.9e-03 |
| 3 | BLA | intron excision ratio | chr10:85161705:85161805 | 0.091 | 0.0490 | 3.6e-04 | 0.034 | 0.037 | 0.027 | 0.026 | 6.0e-03 | 4.3e-03 | 1.4e-02 | 1.4e-02 |
| 4 | Brain | alternative TSS | ENSRNOT00000080167 | 0.033 | 0.0187 | 4.2e-04 | 0.024 | 0.027 | 0.007 | 0.015 | 2.6e-03 | 1.3e-03 | 6.8e-02 | 1.4e-02 |
| 5 | Brain | gene expression | ENSRNOG00000003899 | 0.084 | 0.0430 | 4.4e-06 | 0.070 | 0.068 | 0.068 | 0.067 | 5.0e-07 | 7.2e-07 | 7.2e-07 | 8.3e-07 |
| 6 | Brain | isoform ratio | ENSRNOT00000019133 | 0.192 | 0.0775 | 3.7e-13 | 0.169 | 0.138 | 0.142 | 0.153 | 1.7e-15 | 8.5e-13 | 4.0e-13 | 4.5e-14 |
| 7 | LHb | gene expression | ENSRNOG00000003899 | 0.226 | 0.1127 | 2.0e-04 | 0.143 | 0.140 | 0.174 | 0.171 | 2.9e-04 | 3.4e-04 | 6.5e-05 | 7.3e-05 |
| 8 | Liver | gene expression | ENSRNOG00000003899 | 0.080 | 0.0370 | 2.6e-10 | 0.090 | 0.091 | 0.086 | 0.087 | 3.8e-10 | 2.9e-10 | 7.9e-10 | 6.6e-10 |
| 9 | PL | gene expression | ENSRNOG00000003899 | 0.261 | 0.0819 | 0.0e+00 | 0.201 | 0.203 | 0.219 | 0.226 | 3.1e-15 | 2.3e-15 | 1.3e-16 | 3.8e-17 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mn content in liver | 13.7 | 15.7 | 17.7 | -4.2 | -4.0 | 4.1 | 3.9 | 3.4 | 3.7 | -4.0 | -4.1 | -4.0 |
| K content in liver | 6.4 | 6.4 | 7.2 | -2.7 | -2.7 | 2.6 | 2.4 | 2.3 | 2.4 | -2.5 | -2.7 | -2.4 |
| Extensor digitorum longus weight | 6.2 | 24.7 | 29.5 | 5.0 | 5.4 | -5.4 | -4.9 | -3.7 | -4.8 | 5.2 | 5.2 | 4.9 |
| Intermittent access intake escalation | 5.9 | 5.8 | 7.7 | -2.6 | -2.8 | 2.7 | 2.7 | 1.0 | 2.2 | -2.5 | -2.4 | -2.3 |
| Mg content in liver | 5.9 | 6.1 | 7.1 | -2.7 | -2.6 | 2.5 | 2.3 | 2.3 | 2.4 | -2.4 | -2.6 | -2.3 |
| Se content in liver | 5.8 | 7.0 | 8.9 | -2.6 | -2.7 | 2.5 | 2.1 | 2.4 | 2.7 | -3.0 | -3.0 | -2.7 |
| Ambulatory time before self-admin | 4.8 | 5.0 | 6.2 | 2.3 | 2.0 | -2.1 | -2.2 | -2.1 | -2.5 | 2.2 | 2.3 | 2.4 |
| Intraocular pressure | 4.4 | 6.3 | 9.4 | 2.5 | 3.0 | -3.1 | -2.9 | -1.3 | -2.4 | 2.3 | 2.4 | 2.3 |
| Intermittent access intake day 1-15 change | 4.1 | 4.1 | 6.3 | -2.2 | -2.5 | 2.4 | 2.4 | 0.4 | 1.6 | -2.0 | -1.9 | -1.8 |
| Stereotopy head waving duration, day 7 | 3.6 | 4.4 | 5.5 | -2.2 | -1.9 | 1.9 | 1.8 | 1.9 | 2.3 | -2.3 | -2.2 | -2.3 |
| Delta distance traveled before/after self-admin | 3.6 | 3.9 | 7.3 | -1.9 | -1.1 | 1.2 | 1.5 | 1.8 | 2.7 | -2.3 | -1.9 | -2.6 |
| Time to tail flick, vehicle, after self-admin | 3.6 | 3.9 | 4.9 | 2.2 | 2.1 | -2.2 | -2.0 | -1.4 | -1.8 | 1.8 | 2.0 | 2.0 |
| Intermittent access intake escalation 2 | 3.5 | 3.5 | 4.7 | -2.0 | -2.2 | 2.1 | 2.1 | 0.4 | 1.8 | -2.0 | -1.8 | -1.8 |
| Locomotion distance, session 7 | 3.5 | 4.4 | 6.1 | 2.2 | 2.1 | -1.8 | -1.8 | -1.3 | -2.3 | 2.4 | 2.3 | 2.5 |
| Bone: endosteal estimation | 3.5 | 7.5 | 12.9 | 2.8 | 2.0 | -1.9 | -1.7 | -3.6 | -2.9 | 3.0 | 3.0 | 3.1 |
| Pavlov. Cond. magazine entry latency | 3.4 | 4.4 | 6.4 | -2.3 | -2.5 | 2.4 | 2.1 | 1.2 | 1.8 | -2.0 | -2.3 | -1.8 |
| Time in familiar zone, hab. session 2 | 3.3 | 3.4 | 5.0 | -2.0 | -1.9 | 1.6 | 1.4 | 1.7 | 1.8 | -2.0 | -2.2 | -1.8 |
| Bone: marrow area | 3.3 | 7.1 | 12.3 | 2.6 | 2.0 | -1.9 | -1.6 | -3.5 | -2.9 | 3.0 | 2.9 | 3.0 |
| Pavlov. Cond. magazine entry number | 3.2 | 4.0 | 6.2 | 2.3 | 2.5 | -2.4 | -2.0 | -1.2 | -1.5 | 1.8 | 2.2 | 1.6 |
| Weight adjusted by age | 3.2 | 3.6 | 5.2 | 2.0 | 1.5 | -1.7 | -2.0 | -1.2 | -2.3 | 1.9 | 1.9 | 2.2 |
| Distance traveled before self-admin | 3.1 | 3.4 | 4.7 | 1.8 | 1.4 | -1.7 | -1.8 | -1.9 | -2.2 | 1.8 | 1.8 | 2.0 |
| Bone: cortical apparent density | 2.9 | 3.8 | 5.7 | -2.2 | -2.4 | 2.4 | 2.1 | 1.5 | 1.4 | -1.7 | -1.9 | -1.5 |
| Bone: cortical tissue density | 2.9 | 3.8 | 5.8 | -2.2 | -2.4 | 2.4 | 2.2 | 1.5 | 1.4 | -1.7 | -1.9 | -1.5 |
| Extinction: sum of active levers before priming | 2.8 | 2.9 | 3.8 | 1.7 | 1.5 | -1.5 | -1.4 | -1.9 | -1.7 | 1.8 | 1.7 | 2.0 |
| Delta ambulatory time before/after self-admin | 2.8 | 3.1 | 5.6 | -1.7 | -1.1 | 1.2 | 1.5 | 1.5 | 2.4 | -2.0 | -1.7 | -2.3 |
| Stereotopy head waving bouts, day 7 | 2.5 | 2.8 | 3.4 | -1.8 | -1.6 | 1.5 | 1.4 | 1.5 | 1.8 | -1.8 | -1.8 | -1.8 |
| Pavlov. Cond. change in total contacts | 2.4 | 2.5 | 4.8 | -1.9 | -1.4 | 1.3 | 1.0 | 2.2 | 1.4 | -1.6 | -1.9 | -1.5 |
| Time >=10cm from walls, locomotor time 2 | 2.4 | 2.6 | 3.2 | -1.7 | -1.7 | 1.8 | 1.7 | 1.6 | 1.0 | -1.6 | -1.6 | -1.7 |
| Number of licking bursts | 2.3 | 2.7 | 4.3 | -1.6 | -1.3 | 1.4 | 1.5 | 1.3 | 2.0 | -1.8 | -1.6 | -2.1 |
| Mean num. licks in bursts | 2.3 | 2.8 | 4.5 | 1.6 | 1.3 | -1.4 | -1.5 | -1.4 | -2.0 | 1.8 | 1.6 | 2.1 |
| Degree of sensitization stereotypy | 2.3 | 2.5 | 3.1 | -1.7 | -1.6 | 1.4 | 1.3 | 1.3 | 1.7 | -1.7 | -1.8 | -1.6 |
| Bone: elastic displacement | 2.2 | 2.5 | 3.6 | 1.7 | 1.2 | -1.3 | -1.4 | -1.6 | -1.9 | 1.7 | 1.5 | 1.9 |
| Total zone transitions, hab. session 1 | 2.1 | 2.9 | 4.7 | 1.6 | 2.0 | -2.2 | -2.2 | -0.2 | -1.6 | 1.7 | 1.5 | 1.6 |
| Intermitt. access day 15 inactive lever presses | 2.0 | 2.2 | 4.3 | -1.5 | -2.1 | 2.0 | 1.8 | 0.1 | 1.2 | -1.4 | -1.3 | -0.9 |
| Intermittent access standard deviation | 2.0 | 2.1 | 3.9 | -1.6 | -2.0 | 1.7 | 1.5 | 0.6 | 1.3 | -1.2 | -1.6 | -1.0 |
| Context. condit. distance diff. score | 2.0 | 2.4 | 4.8 | 1.3 | 1.7 | -2.0 | -2.2 | 0.3 | -1.4 | 1.4 | 1.2 | 1.6 |
| Total zone transitions, NPP test | 2.0 | 2.9 | 3.3 | 1.8 | 1.7 | -1.7 | -1.6 | -1.6 | -1.7 | 1.7 | 1.8 | 1.7 |
| Intermitt. access day 1 inactive lever presses | 1.9 | 2.1 | 2.8 | -1.5 | -1.4 | 1.2 | 1.0 | 1.6 | 1.7 | -1.5 | -1.6 | -1.3 |
| Time in closed arm after self-admin | 1.9 | 1.9 | 4.1 | -1.2 | -0.8 | 0.6 | 0.5 | 2.0 | 1.8 | -1.7 | -1.6 | -1.5 |
| Rb content in liver | 1.9 | 2.4 | 2.8 | -1.7 | -1.3 | 1.4 | 1.4 | 1.6 | 1.7 | -1.6 | -1.6 | -1.5 |
| Liver weight, right | 1.8 | 3.0 | 5.3 | -1.7 | -1.6 | 1.5 | 1.2 | 2.3 | 1.6 | -1.9 | -2.0 | -1.6 |
| Median of all reaction times | 1.8 | 2.5 | 3.4 | -1.7 | -1.9 | 1.8 | 1.5 | 1.4 | 1.4 | -1.4 | -1.6 | -1.5 |
| Delay disc. indifference point, 24s delay | 1.8 | 1.8 | 3.4 | 1.3 | 1.3 | -1.4 | -1.6 | 0.1 | -1.8 | 1.2 | 1.3 | 1.4 |
| Time in familiar zone, hab. session 1 | 1.7 | 1.6 | 1.9 | -1.4 | -1.2 | 1.3 | 1.3 | 1.3 | 1.3 | -1.2 | -1.4 | -1.2 |
| Locomotion velocity, NPP test | 1.7 | 2.4 | 2.7 | 1.5 | 1.6 | -1.5 | -1.4 | -1.4 | -1.5 | 1.6 | 1.6 | 1.7 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.7 | 2.1 | 2.8 | -1.6 | -1.6 | 1.7 | 1.5 | 1.0 | 1.2 | -1.4 | -1.6 | -1.3 |
| Stereotopy head waving bouts, day 3 | 1.6 | 1.9 | 2.2 | -1.4 | -1.4 | 1.4 | 1.2 | 1.3 | 1.4 | -1.5 | -1.5 | -1.4 |
| Locomotion velocity, session 8 | 1.6 | 1.9 | 3.2 | 1.3 | 1.8 | -1.6 | -1.5 | -0.7 | -1.3 | 1.4 | 1.4 | 1.2 |
| Time in closed arm before self-admin | 1.6 | 1.8 | 2.9 | -1.1 | -1.2 | 1.0 | 0.9 | 1.3 | 1.7 | -1.7 | -1.5 | -1.6 |
| Water consumed over 24 hours | 1.5 | 1.8 | 2.9 | -1.3 | -0.9 | 1.2 | 1.4 | 0.7 | 1.7 | -1.5 | -1.3 | -1.7 |
| Degree of sensitization distance | 1.5 | 1.6 | 2.3 | 1.3 | 1.5 | -1.1 | -0.9 | -0.8 | -1.2 | 1.4 | 1.5 | 1.2 |
| Bone: trabecular number | 1.5 | 2.4 | 5.0 | -1.7 | -2.2 | 2.0 | 1.7 | 0.1 | 1.0 | -1.3 | -1.6 | -1.1 |
| Vertical activity count, locomotor time 2 | 1.5 | 1.6 | 2.8 | 1.2 | 0.7 | -1.0 | -1.1 | -1.3 | -1.7 | 1.4 | 1.2 | 1.5 |
| Social time | 1.4 | 1.9 | 3.0 | 1.5 | 1.1 | -0.8 | -0.7 | -1.2 | -1.6 | 1.6 | 1.6 | 1.7 |
| Conditioned locomotion | 1.4 | 1.6 | 3.2 | 1.5 | 0.7 | -1.0 | -1.2 | -1.4 | -1.8 | 1.2 | 1.1 | 1.2 |
| Compulsive drug intake | 1.4 | 1.4 | 2.5 | 1.2 | 1.6 | -1.3 | -1.2 | -0.3 | -0.9 | 1.3 | 1.3 | 1.0 |
| Total heroin consumption | 1.4 | 1.7 | 2.7 | -1.3 | -1.3 | 1.2 | 1.3 | 0.4 | 1.5 | -1.4 | -1.5 | -1.6 |
| Delay disc. indifference point, 8s delay | 1.4 | 1.4 | 2.5 | 1.1 | 0.9 | -0.9 | -1.0 | -0.7 | -1.6 | 1.5 | 1.2 | 1.6 |
| Total resting periods, locomotor time 2 | 1.4 | 1.5 | 2.8 | 1.0 | 0.9 | -1.1 | -1.4 | 0.6 | -1.6 | 1.5 | 0.8 | 1.7 |
| Delay discounting total patch changes 12 sec | 1.3 | 1.7 | 3.0 | -1.1 | -1.7 | 1.7 | 1.5 | 0.7 | 1.2 | -1.1 | -1.3 | -1.2 |
| Reaction time num false alarms | 1.3 | 1.8 | 2.4 | -1.3 | -1.3 | 1.4 | 1.5 | 0.7 | 1.4 | -1.4 | -1.5 | -1.4 |
| Reaction time false alarm rate | 1.3 | 1.8 | 2.4 | -1.2 | -1.5 | 1.5 | 1.6 | 0.4 | 1.5 | -1.3 | -1.4 | -1.3 |
| Pavlov. Cond. index score | 1.3 | 1.6 | 2.4 | -1.5 | -1.5 | 1.6 | 1.4 | 0.7 | 1.0 | -1.1 | -1.4 | -1.1 |
| Bone: endosteal perimeter | 1.3 | 2.8 | 7.9 | 1.6 | 1.1 | -1.0 | -0.7 | -2.8 | -1.6 | 1.8 | 1.8 | 1.7 |
| Run reversals in cocaine runway, females | 1.3 | 1.3 | 2.9 | 1.0 | 1.4 | -1.4 | -1.7 | 0.5 | -0.9 | 0.9 | 0.9 | 1.0 |
| Right kidney weight | 1.2 | 3.5 | 8.0 | -1.4 | -1.1 | 1.2 | 1.1 | 2.8 | 2.2 | -2.2 | -1.7 | -2.3 |
| Delay discounting water rate 6 sec | 1.2 | 1.7 | 2.1 | -1.3 | -1.5 | 1.4 | 1.2 | 1.3 | 1.1 | -1.3 | -1.3 | -1.3 |
| Reaction time num false alarms AUC | 1.2 | 1.7 | 2.8 | -1.2 | -1.3 | 1.5 | 1.7 | 0.4 | 1.4 | -1.3 | -1.3 | -1.2 |
| Short access day 10 total infusions | 1.2 | 1.3 | 2.6 | 1.1 | 0.6 | -0.6 | -0.7 | -1.2 | -1.6 | 1.5 | 1.2 | 1.4 |
| Total zone transitions, hab. session 2 | 1.2 | 1.5 | 2.1 | 1.3 | 1.4 | -1.4 | -1.2 | -0.8 | -1.1 | 1.2 | 1.4 | 1.1 |
| Pavlov. Cond. response bias | 1.2 | 1.5 | 2.2 | -1.5 | -1.5 | 1.4 | 1.0 | 1.2 | 0.9 | -1.1 | -1.5 | -0.9 |
| Bone: periosteal estimation | 1.2 | 2.5 | 5.4 | 1.6 | 0.7 | -0.5 | -0.5 | -2.3 | -1.8 | 1.8 | 1.8 | 1.9 |
| Delta time to tail flick, vehicle, before/after SA | 1.2 | 1.2 | 2.4 | 1.2 | 0.7 | -0.7 | -0.7 | -1.1 | -1.6 | 1.1 | 1.1 | 1.3 |
| Reaction time omissions | 1.1 | 1.5 | 2.0 | -1.3 | -1.4 | 1.4 | 1.3 | 0.6 | 1.2 | -1.2 | -1.2 | -1.1 |
| Locomotion distance, session 1 | 1.1 | 1.4 | 2.0 | 1.2 | 1.0 | -0.9 | -0.8 | -1.4 | -1.3 | 1.2 | 1.3 | 1.3 |
| Locomotion distance, session 3 | 1.1 | 1.2 | 1.7 | 1.1 | 1.0 | -1.1 | -1.2 | -0.7 | -1.1 | 1.2 | 1.1 | 1.3 |
| Pavlov. Cond. latency score | 1.1 | 1.4 | 2.2 | -1.4 | -1.3 | 1.5 | 1.3 | 0.7 | 0.9 | -1.0 | -1.2 | -1.0 |
| Bone: cortical thickness | 1.1 | 1.3 | 2.7 | -1.0 | -1.5 | 1.3 | 0.7 | 1.6 | 0.7 | -1.0 | -1.3 | -0.8 |
| Change in fecal boli incidents, locomotor task | 1.1 | 1.0 | 2.0 | -0.9 | -0.5 | 0.5 | 0.4 | 1.4 | 1.3 | -1.3 | -1.1 | -1.0 |
| Bouts of movement, locomotor time 2 | 1.1 | 1.2 | 2.4 | 0.9 | 0.7 | -0.9 | -1.2 | 0.6 | -1.6 | 1.3 | 0.6 | 1.5 |
| Tail length | 1.0 | 3.0 | 4.6 | 1.8 | 1.6 | -1.7 | -2.0 | -0.5 | -2.1 | 1.8 | 1.6 | 1.9 |
| Tibialis anterior weight | 1.0 | 3.6 | 4.9 | 1.7 | 2.1 | -2.2 | -2.0 | -1.3 | -1.8 | 2.0 | 2.0 | 1.9 |
| Delay discounting water rate 18 sec | 1.0 | 1.3 | 1.8 | -1.2 | -0.9 | 1.2 | 1.2 | 1.3 | 1.4 | -1.1 | -0.9 | -1.1 |
| Locomotor activity | 1.0 | 1.7 | 2.1 | -1.2 | -1.4 | 1.4 | 1.3 | 0.6 | 1.2 | -1.4 | -1.5 | -1.3 |
| Locomotor testing distance | 1.0 | 1.7 | 3.0 | -1.3 | -1.7 | 1.5 | 1.3 | 0.2 | 1.1 | -1.4 | -1.5 | -1.2 |
| Condit. Reinf. inactive responses | 1.0 | 1.3 | 3.1 | -1.1 | -1.8 | 1.6 | 1.4 | -0.4 | 0.6 | -0.9 | -1.0 | -0.6 |
| Intermittent access day 15 total infusions | 0.9 | 1.0 | 1.9 | -1.1 | -1.4 | 1.2 | 1.1 | 0.4 | 0.7 | -1.0 | -1.0 | -0.9 |
| Bone: minimum diameter | 0.9 | 1.7 | 3.4 | 1.2 | 0.7 | -0.6 | -0.6 | -1.8 | -1.6 | 1.5 | 1.4 | 1.6 |
| Bone: post-yield work | 0.9 | 1.3 | 2.1 | 1.2 | 1.4 | -1.1 | -1.0 | -0.6 | -0.9 | 1.3 | 1.4 | 1.0 |
| Sum of active levers in priming session hrs 5-6 | 0.9 | 0.8 | 1.5 | -1.1 | -1.1 | 0.8 | 0.7 | 0.6 | 0.8 | -0.9 | -1.2 | -0.7 |
| Left kidney weight | 0.8 | 2.4 | 9.1 | -1.1 | -0.5 | 0.6 | 0.5 | 3.0 | 1.5 | -1.7 | -1.3 | -1.8 |
| Length with tail | 0.8 | 3.1 | 4.7 | 1.8 | 2.1 | -1.6 | -1.6 | -0.3 | -1.9 | 2.0 | 2.2 | 1.7 |
| Intermittent access day 1 total infusions | 0.8 | 0.9 | 1.3 | 0.9 | 0.8 | -0.8 | -0.9 | -0.7 | -1.1 | 1.1 | 1.0 | 0.9 |
| Novel to familiar place preference ratio | 0.8 | 0.8 | 1.3 | 0.8 | 0.8 | -0.9 | -1.1 | -0.7 | -1.0 | 0.9 | 0.8 | 1.0 |
| Bone: elastic work | 0.8 | 1.1 | 2.4 | 1.0 | 0.3 | -0.6 | -0.9 | -1.0 | -1.4 | 1.1 | 0.8 | 1.5 |
| Bone: maximum moment | 0.8 | 1.4 | 2.4 | 1.2 | 0.4 | -0.1 | -0.2 | -1.6 | -1.4 | 1.4 | 1.4 | 1.5 |
| Bone: trabecular spacing | 0.8 | 1.1 | 1.8 | 1.1 | 1.3 | -1.2 | -1.1 | -0.7 | -0.8 | 1.0 | 1.2 | 0.8 |
| Heart weight | 0.7 | 1.0 | 3.1 | 1.1 | 1.8 | -1.4 | -1.0 | 0.0 | -0.1 | 0.7 | 1.1 | 0.3 |
| Reaction time mean minus median | 0.7 | 0.9 | 1.3 | 0.9 | 0.9 | -0.7 | -0.5 | -1.0 | -1.1 | 1.1 | 1.1 | 1.0 |
| Reaction time mean | 0.7 | 1.0 | 1.4 | -1.1 | -1.2 | 1.2 | 1.0 | 1.0 | 0.8 | -0.7 | -1.0 | -0.9 |
| Intermittent access day 1 locomotion | 0.7 | 0.7 | 2.0 | 0.9 | 0.4 | -0.3 | -0.2 | -1.4 | -0.9 | 0.9 | 1.0 | 0.7 |
| Incentive Sensitization - Responses | 0.7 | 0.7 | 2.7 | 0.5 | -0.1 | 0.2 | 0.3 | -1.7 | -0.9 | 0.9 | 0.9 | 0.8 |
| Incentive Sensitization - Breakpoint | 0.7 | 0.7 | 2.7 | 0.4 | -0.3 | 0.4 | 0.4 | -1.7 | -0.8 | 0.9 | 0.8 | 0.7 |
| Short access day 10 total inactive lever presses | 0.7 | 0.7 | 1.4 | 0.8 | 0.7 | -0.8 | -0.9 | -0.4 | -0.4 | 1.2 | 0.8 | 1.2 |
| Locomotion distance, session 8 | 0.7 | 1.1 | 1.8 | 0.9 | 1.1 | -1.2 | -1.4 | -0.2 | -1.0 | 1.0 | 0.8 | 1.2 |
| Time in novel zone, hab. session 2 | 0.7 | 0.7 | 1.4 | 1.1 | 0.8 | -0.5 | -0.3 | -0.9 | -0.7 | 0.8 | 1.2 | 0.7 |
| Bone: cortical thickness | 0.7 | 1.1 | 2.0 | -0.9 | -1.1 | 1.3 | 1.0 | 1.4 | 0.7 | -0.9 | -0.9 | -0.9 |
| Time to tail flick, test, before self-admin | 0.7 | 0.7 | 1.0 | 1.0 | 0.8 | -0.8 | -0.7 | -1.0 | -0.8 | 0.8 | 1.0 | 0.7 |
| Delay discount exponential model param | 0.7 | 0.7 | 1.4 | -0.5 | -0.7 | 0.9 | 1.2 | -0.2 | 1.1 | -0.9 | -0.6 | -1.0 |
| Delay discount hyperbolic model param | 0.7 | 0.7 | 1.3 | -0.6 | -0.6 | 0.9 | 1.1 | -0.0 | 1.2 | -0.9 | -0.6 | -1.1 |
| Time >=10cm from walls, locomotor time 1 | 0.7 | 0.7 | 1.4 | -0.9 | -0.6 | 0.8 | 0.8 | 1.2 | 0.6 | -0.8 | -0.7 | -0.9 |
| Run reversals in cocaine runway, males | 0.7 | 0.7 | 1.5 | 0.9 | 0.6 | -0.6 | -0.8 | -0.1 | -1.2 | 0.8 | 1.0 | 1.0 |
| Na content in liver | 0.7 | 0.8 | 1.8 | -0.8 | -1.3 | 1.2 | 1.2 | -1.2 | 0.2 | -0.2 | -0.5 | -0.2 |
| Social response proportion | 0.6 | 0.6 | 2.1 | 0.6 | 0.9 | -1.1 | -1.1 | 1.4 | -0.1 | 0.0 | 0.1 | 0.2 |
| Intermittent access day 15 total locomotion | 0.6 | 0.7 | 1.8 | -0.4 | -1.0 | 1.1 | 1.3 | -1.2 | 0.3 | -0.2 | -0.2 | -0.4 |
| Novelty place preference | 0.6 | 0.6 | 1.0 | 0.8 | 0.7 | -0.8 | -1.0 | -0.4 | -0.8 | 0.8 | 0.7 | 0.8 |
| Diff in mean of infusions in LGA sessions | 0.6 | 0.7 | 1.4 | 0.9 | 0.5 | -0.8 | -1.0 | -0.5 | -0.7 | 1.0 | 0.5 | 1.2 |
| Area under the delay curve | 0.6 | 0.6 | 1.2 | 0.5 | 0.6 | -0.8 | -1.1 | 0.1 | -1.1 | 0.9 | 0.5 | 1.0 |
| Light reinforcement 1 | 0.5 | 0.9 | 1.6 | -0.8 | -1.2 | 1.2 | 0.8 | 1.3 | 0.3 | -0.9 | -1.0 | -0.6 |
| Conditioned locomotion | 0.5 | 0.6 | 1.0 | -0.6 | -0.6 | 0.5 | 0.3 | 1.0 | 0.8 | -0.9 | -0.9 | -1.0 |
| Saline control response | 0.5 | 0.6 | 1.0 | 0.7 | 0.7 | -0.6 | -0.7 | -0.5 | -0.9 | 1.0 | 0.8 | 1.0 |
| Condit. Reinf. active responses | 0.5 | 0.7 | 1.8 | -0.6 | -1.3 | 1.3 | 1.2 | -0.0 | 0.3 | -0.5 | -0.6 | -0.4 |
| Condit. Reinf. lever reinforcers received | 0.5 | 0.6 | 1.7 | -0.7 | -1.3 | 1.2 | 1.0 | 0.1 | 0.3 | -0.5 | -0.7 | -0.4 |
| Conditioned reinforcement - inactives | 0.5 | 0.6 | 1.5 | -0.7 | -0.8 | 1.1 | 1.2 | -0.1 | 0.5 | -0.5 | -0.4 | -0.9 |
| Intermittent access terminal intake (last 3 days) | 0.5 | 0.5 | 1.2 | -0.8 | -1.1 | 1.1 | 0.9 | 0.0 | 0.1 | -0.4 | -0.6 | -0.5 |
| Short access total locomotion | 0.5 | 0.5 | 1.0 | 0.6 | 0.1 | -0.1 | -0.1 | -1.0 | -0.9 | 1.0 | 0.6 | 0.9 |
| Number of responses in last shaping day | 0.5 | 0.5 | 1.0 | -0.6 | -1.0 | 0.8 | 0.6 | 0.0 | 0.7 | -0.7 | -0.8 | -0.7 |
| Locomotion velocity, hab. session 1 | 0.5 | 0.8 | 1.5 | 0.6 | 0.9 | -1.1 | -1.2 | 0.1 | -1.0 | 0.9 | 0.6 | 1.0 |
| Total locomotion distance, NPP test | 0.5 | 0.7 | 1.2 | 0.9 | 0.8 | -0.7 | -0.6 | -1.1 | -0.8 | 0.8 | 1.0 | 0.9 |
| Bone: connectivity density | 0.5 | 0.8 | 2.0 | -1.0 | -1.4 | 1.2 | 1.0 | -0.2 | 0.5 | -0.7 | -1.0 | -0.6 |
| Bone: cortical porosity | 0.5 | 0.5 | 1.2 | 0.5 | 0.0 | -0.4 | -0.5 | -1.1 | -1.0 | 0.8 | 0.4 | 1.0 |
| Bone: periosteal perimeter | 0.5 | 0.8 | 2.5 | 0.9 | 0.4 | -0.2 | -0.1 | -1.6 | -1.0 | 1.0 | 1.1 | 1.0 |
| Ambulatory time after self-admin | 0.5 | 0.6 | 1.1 | 0.8 | 1.0 | -1.1 | -0.8 | -1.0 | 0.1 | 0.4 | 0.8 | 0.1 |
| Delay disc. indifference point, 16s delay | 0.5 | 0.5 | 2.8 | -0.2 | 0.0 | -0.5 | -0.9 | 1.7 | -0.2 | -0.1 | -0.5 | 0.2 |
| Fecal boli incidents, locomotor time 1 | 0.5 | 0.6 | 1.4 | -0.5 | -0.4 | 0.5 | 1.0 | -0.5 | 1.0 | -0.8 | -0.4 | -1.2 |
| Cd content in liver | 0.5 | 0.6 | 1.7 | 0.5 | 1.0 | -1.3 | -1.2 | 0.5 | -0.4 | 0.5 | 0.3 | 0.5 |
| BMI without tail | 0.4 | 0.7 | 1.4 | 1.0 | 0.9 | -1.2 | -1.1 | -0.7 | -0.7 | 0.6 | 0.5 | 0.7 |
| Body weight | 0.4 | 1.8 | 4.2 | 1.5 | 2.0 | -1.4 | -0.8 | -1.1 | -1.0 | 1.2 | 1.8 | 0.7 |
| Locomotor testing rearing | 0.4 | 0.6 | 1.7 | -0.8 | -1.3 | 0.8 | 0.3 | 0.5 | 0.1 | -0.7 | -1.2 | -0.1 |
| Reaction time mean minus median AUC | 0.4 | 0.5 | 0.8 | 0.6 | 0.5 | -0.4 | -0.2 | -0.8 | -0.9 | 0.9 | 0.9 | 0.9 |
| Reaction time mean AUC | 0.4 | 0.5 | 0.9 | -0.8 | -1.0 | 0.8 | 0.7 | 0.7 | 0.5 | -0.4 | -0.7 | -0.5 |
| Cocaine response after cond. corrected | 0.4 | 0.4 | 0.6 | -0.4 | -0.8 | 0.8 | 0.5 | 0.5 | 0.6 | -0.8 | -0.7 | -0.6 |
| Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 1.5 | 0.3 | 1.2 | -0.9 | -0.8 | 1.0 | -0.3 | 0.5 | 0.4 | 0.5 |
| Pavlov. Cond. response bias | 0.4 | 0.6 | 0.9 | -0.6 | -0.9 | 0.9 | 0.8 | 0.4 | 0.7 | -0.8 | -0.7 | -0.8 |
| Intermittent access total locomotion | 0.4 | 0.4 | 0.9 | -0.4 | -0.9 | 0.9 | 0.9 | -0.4 | 0.4 | -0.5 | -0.4 | -0.6 |
| Short access total infusions | 0.4 | 0.5 | 1.3 | 0.4 | 0.2 | -0.2 | -0.6 | -0.1 | -1.2 | 1.1 | 0.6 | 0.9 |
| Short access day 10 total locomotion | 0.4 | 0.4 | 1.5 | -0.1 | -0.8 | 0.9 | 1.0 | -1.2 | -0.0 | 0.1 | -0.1 | -0.1 |
| Locomotion velocity, hab. session 2 | 0.4 | 0.5 | 0.7 | 0.6 | 0.9 | -0.8 | -0.6 | -0.7 | -0.5 | 0.6 | 0.7 | 0.6 |
| Pavlov. Cond. lever latency | 0.4 | 0.5 | 1.0 | 0.9 | 0.6 | -0.8 | -0.7 | -1.0 | -0.6 | 0.6 | 0.7 | 0.6 |
| Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 1.0 | 0.7 | 0.8 | -1.0 | -0.9 | -0.5 | -0.5 | 0.5 | 0.7 | 0.5 |
| Bone: apparent density | 0.4 | 0.7 | 1.9 | -0.8 | -1.4 | 1.2 | 1.0 | -0.6 | 0.3 | -0.5 | -0.8 | -0.4 |
| Bone surface | 0.4 | 0.7 | 3.4 | 0.5 | -0.1 | 0.3 | 0.2 | -1.9 | -0.9 | 0.8 | 0.7 | 0.9 |
| Bone volume | 0.4 | 0.6 | 3.3 | 0.1 | -0.6 | 0.8 | 0.8 | -1.8 | -0.4 | 0.4 | 0.3 | 0.5 |
| Bone: cortical porosity | 0.4 | 0.5 | 0.9 | 0.5 | 0.1 | -0.4 | -0.5 | -0.9 | -1.0 | 0.7 | 0.4 | 0.9 |
| Bone: maximum force | 0.4 | 0.8 | 1.6 | 0.9 | 0.1 | 0.2 | 0.1 | -1.3 | -1.0 | 1.0 | 1.1 | 1.1 |
| Bone: trabecular thickness | 0.4 | 0.4 | 1.0 | -0.3 | -0.8 | 0.9 | 1.0 | -0.9 | 0.5 | -0.5 | -0.3 | -0.4 |
| Breakpoint value in progressive ratio session | 0.4 | 0.5 | 1.1 | -0.8 | -0.6 | 0.3 | 0.2 | 0.9 | 0.7 | -0.5 | -1.1 | -0.6 |
| Active lever presses in extinction session 6 | 0.4 | 0.4 | 1.2 | -0.6 | -1.1 | 0.7 | 0.5 | 0.2 | 0.5 | -0.7 | -0.9 | -0.3 |
| Time in open arm before self-admin | 0.4 | 0.5 | 1.0 | 0.6 | 0.8 | -0.6 | -0.5 | 0.0 | -1.0 | 0.8 | 0.7 | 0.7 |
| Time in open arm after self-admin | 0.4 | 0.4 | 0.9 | 0.7 | 0.7 | -0.4 | -0.2 | -0.9 | -0.6 | 0.8 | 0.9 | 0.5 |
| Total resting periods, locomotor time 1 | 0.4 | 0.5 | 0.8 | 0.6 | 0.8 | -0.7 | -0.5 | -0.5 | -0.6 | 0.9 | 0.8 | 0.6 |
| Vertical activity count, locomotor time 1 | 0.4 | 0.4 | 0.7 | 0.6 | 0.3 | -0.4 | -0.7 | -0.8 | -0.6 | 0.6 | 0.6 | 0.8 |
| Latency to leave start box in cocaine runway, F | 0.4 | 0.5 | 1.1 | 0.6 | 0.9 | -1.0 | -1.0 | 0.4 | -0.1 | 0.5 | 0.3 | 0.5 |
| Mean time between licks in bursts | 0.3 | 0.4 | 1.3 | -0.4 | 0.1 | 0.1 | 0.7 | -0.0 | 1.1 | -0.8 | -0.4 | -1.1 |
| Indifference point AUC | 0.3 | 0.4 | 0.5 | -0.7 | -0.6 | 0.6 | 0.7 | 0.7 | 0.6 | -0.6 | -0.7 | -0.7 |
| Reaction time premature initiation rate | 0.3 | 0.4 | 0.8 | -0.5 | -0.9 | 0.5 | -0.0 | 0.9 | 0.5 | -0.7 | -0.9 | -0.4 |
| Cocaine response after cond. not corrected | 0.3 | 0.3 | 0.5 | -0.1 | -0.6 | 0.7 | 0.5 | 0.5 | 0.6 | -0.6 | -0.4 | -0.6 |
| Conditioned reinforcement - actives | 0.3 | 0.3 | 1.0 | 0.6 | 0.4 | -0.5 | -0.6 | -0.3 | -1.0 | 0.5 | 0.4 | 0.5 |
| Cocaine induced anxiety | 0.3 | 0.4 | 1.1 | 0.4 | 0.7 | -0.9 | -1.0 | 0.5 | -0.5 | 0.6 | 0.4 | 0.5 |
| Post-drug Anxiety | 0.3 | 0.3 | 1.1 | 0.2 | 0.7 | -0.9 | -1.0 | 0.6 | -0.1 | 0.4 | 0.1 | 0.1 |
| Progressive ratio test 1 inactive lever presses | 0.3 | 0.3 | 0.7 | -0.5 | -0.5 | 0.7 | 0.5 | 0.5 | 0.9 | -0.3 | -0.4 | -0.5 |
| Total sessions with >9 infusions | 0.3 | 0.3 | 0.8 | 0.5 | 0.2 | -0.5 | -0.8 | 0.0 | -0.5 | 0.9 | 0.3 | 0.7 |
| One hour access (0.3 mA shock) | 0.3 | 0.4 | 0.9 | 0.5 | 0.2 | -0.2 | -0.3 | -0.7 | -1.0 | 0.8 | 0.7 | 0.7 |
| Locomotion velocity, session 3 | 0.3 | 0.4 | 1.0 | 0.6 | 0.6 | -0.8 | -1.0 | 0.2 | -0.6 | 0.5 | 0.4 | 0.7 |
| Locomotion velocity, session 7 | 0.3 | 0.3 | 0.6 | 0.7 | 0.7 | -0.3 | -0.0 | -0.4 | -0.3 | 0.5 | 0.8 | 0.4 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.4 | 1.3 | -0.5 | -0.6 | 0.2 | -0.1 | 1.1 | 0.4 | -0.5 | -0.8 | -0.3 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.4 | 0.9 | 0.3 | 0.6 | -0.8 | -1.0 | 0.6 | -0.7 | 0.6 | 0.3 | 0.7 |
| Bone: final force | 0.3 | 0.5 | 1.9 | -0.3 | -0.9 | 1.4 | 1.3 | -0.0 | 0.2 | -0.3 | -0.1 | -0.3 |
| Bone: tissue strength | 0.3 | 0.3 | 0.8 | 0.5 | 0.9 | -0.5 | -0.2 | 0.1 | -0.5 | 0.6 | 0.7 | 0.6 |
| Time to tail flick, vehicle, before self-admin | 0.3 | 0.3 | 1.4 | 0.4 | 0.6 | -0.4 | -0.1 | -1.2 | 0.3 | 0.3 | 0.6 | 0.1 |
| Time to tail flick, test, after self-admin | 0.3 | 0.3 | 0.7 | -0.6 | -0.4 | 0.6 | 0.8 | 0.2 | 0.4 | -0.6 | -0.4 | -0.7 |
| Delta time to tail flick, test, before/after SA | 0.3 | 0.3 | 0.6 | -0.5 | -0.3 | 0.5 | 0.5 | 0.7 | 0.5 | -0.5 | -0.5 | -0.5 |
| Distance moved, locomotor task time 2 | 0.3 | 0.3 | 1.3 | 0.5 | 0.1 | -0.2 | -0.5 | -0.4 | -1.1 | 0.4 | 0.6 | 0.6 |
| Locomotion in novel chamber post-restriction | 0.3 | 0.3 | 1.9 | -0.1 | -0.5 | 0.5 | 0.5 | -1.4 | -0.2 | -0.2 | 0.0 | -0.1 |
| Sr content in liver | 0.3 | 0.2 | 0.6 | -0.1 | -0.1 | 0.2 | 0.2 | 0.8 | 0.6 | -0.6 | -0.3 | -0.7 |
| Zn content in liver | 0.3 | 0.3 | 0.6 | -0.7 | -0.5 | 0.2 | 0.2 | 0.8 | 0.6 | -0.6 | -0.8 | -0.5 |
| Food consumed during 24 hour testing period | 0.2 | 0.2 | 0.5 | -0.5 | 0.2 | -0.1 | 0.1 | 0.7 | 0.6 | -0.4 | -0.4 | -0.6 |
| Indifference point function ln k | 0.2 | 0.2 | 0.4 | 0.4 | 0.6 | -0.3 | -0.4 | 0.1 | -0.6 | 0.4 | 0.6 | 0.6 |
| Indifference point function log k | 0.2 | 0.2 | 0.4 | 0.4 | 0.6 | -0.3 | -0.4 | 0.1 | -0.6 | 0.4 | 0.6 | 0.6 |
| Delay discounting total patch changes 24 sec | 0.2 | 0.2 | 0.5 | -0.4 | -0.7 | 0.6 | 0.3 | 0.6 | 0.4 | -0.2 | -0.6 | -0.3 |
| Reaction time number correct | 0.2 | 0.2 | 0.6 | 0.4 | 0.8 | -0.6 | -0.3 | -0.4 | -0.5 | 0.4 | 0.6 | 0.4 |
| Reaction time trials correct on left | 0.2 | 0.2 | 0.6 | 0.4 | 0.8 | -0.6 | -0.3 | -0.4 | -0.5 | 0.4 | 0.6 | 0.4 |
| Social responses | 0.2 | 0.2 | 1.4 | -0.2 | 0.0 | -0.1 | -0.1 | 1.2 | 0.4 | -0.4 | -0.5 | -0.2 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.6 | -0.4 | -0.7 | 0.8 | 0.7 | 0.3 | 0.2 | -0.3 | -0.3 | -0.3 |
| Condit. Reinf. lever presses | 0.2 | 0.2 | 0.5 | 0.3 | -0.1 | -0.2 | -0.5 | -0.5 | -0.7 | 0.5 | 0.2 | 0.7 |
| Pavlov. Cond. change in total contacts | 0.2 | 0.3 | 0.7 | -0.5 | -0.8 | 0.8 | 0.8 | 0.1 | 0.4 | -0.4 | -0.4 | -0.5 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.6 | -0.4 | -0.8 | 0.6 | 0.6 | 0.1 | 0.5 | -0.6 | -0.5 | -0.6 |
| Baseline Anxiety | 0.2 | 0.3 | 0.8 | 0.5 | 0.1 | -0.2 | -0.2 | -0.9 | -0.5 | 0.6 | 0.4 | 0.5 |
| Lifetime Intake | 0.2 | 0.2 | 0.7 | 0.3 | 0.0 | -0.0 | -0.3 | -0.3 | -0.8 | 0.7 | 0.5 | 0.6 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.7 | 0.2 | 0.1 | -0.0 | -0.2 | -0.1 | -0.6 | 0.8 | 0.3 | 0.7 |
| Progressive ratio test 2 active lever presses | 0.2 | 0.2 | 0.4 | -0.1 | -0.5 | 0.6 | 0.5 | -0.6 | -0.4 | 0.4 | 0.2 | 0.3 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.3 | 0.8 | 0.1 | -0.4 | 0.5 | 0.4 | -0.9 | -0.6 | 0.6 | 0.4 | 0.5 |
| Progressive ratio test 2 inactive lever presses | 0.2 | 0.2 | 0.6 | -0.3 | -0.7 | 0.8 | 0.7 | -0.5 | 0.2 | -0.1 | -0.0 | -0.1 |
| Short access day 1 total infusions | 0.2 | 0.2 | 0.9 | 0.1 | -0.0 | 0.0 | -0.3 | 0.1 | -0.9 | 0.5 | 0.3 | 0.5 |
| Short access day 1 locomotion | 0.2 | 0.2 | 0.7 | 0.1 | -0.4 | 0.1 | -0.3 | -0.2 | -0.8 | 0.6 | -0.0 | 0.8 |
| Locomotion velocity, session 1 | 0.2 | 0.2 | 0.8 | 0.5 | -0.2 | 0.3 | 0.2 | -0.9 | -0.5 | 0.4 | 0.4 | 0.5 |
| Incentive salience index mean | 0.2 | 0.3 | 0.8 | -0.6 | -0.6 | 0.4 | 0.1 | 0.9 | 0.3 | -0.4 | -0.8 | -0.2 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.2 | 0.6 | 0.4 | 0.6 | -0.5 | -0.3 | -0.8 | -0.3 | 0.4 | 0.5 | 0.4 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.4 | -0.6 | -0.3 | 0.4 | 0.4 | 0.4 | 0.4 | -0.3 | -0.4 | -0.4 |
| Bone: final moment | 0.2 | 0.4 | 1.4 | -0.0 | -0.7 | 1.2 | 1.1 | -0.4 | -0.1 | 0.0 | 0.2 | 0.1 |
| Bone: maximum diameter | 0.2 | 0.3 | 1.0 | 0.2 | -0.4 | 0.6 | 0.5 | -1.0 | -0.5 | 0.5 | 0.5 | 0.5 |
| Bone: trabecular tissue density | 0.2 | 0.3 | 1.8 | 0.2 | 0.6 | -0.2 | -0.3 | 1.3 | 0.1 | 0.1 | 0.3 | 0.1 |
| Distance traveled after self-admin | 0.2 | 0.2 | 0.5 | 0.2 | 0.6 | -0.7 | -0.5 | -0.3 | 0.5 | -0.1 | 0.2 | -0.4 |
| Delta time in open arm before/after self-admin | 0.2 | 0.2 | 0.6 | -0.4 | -0.2 | 0.2 | 0.3 | -0.1 | 0.8 | -0.5 | -0.3 | -0.6 |
| Delay disc. indifference point, 0s delay | 0.2 | 0.2 | 0.4 | 0.1 | -0.2 | -0.1 | -0.3 | -0.7 | -0.6 | 0.5 | 0.2 | 0.6 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.3 | 0.9 | 0.2 | -0.4 | 0.3 | 0.2 | -0.9 | -0.6 | 0.5 | 0.3 | 0.7 |
| Rest time, locomotor task time 2 | 0.2 | 0.2 | 0.9 | 0.4 | 0.9 | -0.7 | -0.4 | -0.1 | 0.1 | 0.4 | 0.5 | 0.2 |
| Seeking ratio, delayed vs. immediate footshock | 0.2 | 0.2 | 1.0 | -0.2 | 0.2 | -0.5 | -0.7 | 1.0 | -0.1 | 0.2 | -0.2 | 0.3 |
| Locomotion in novel chamber | 0.2 | 0.2 | 0.6 | -0.4 | -0.7 | 0.4 | -0.1 | 0.4 | -0.6 | 0.1 | -0.5 | 0.2 |
| Seeking ratio, punishment vs. effort | 0.2 | 0.2 | 0.6 | -0.2 | -0.1 | 0.2 | 0.3 | 0.8 | 0.7 | -0.3 | -0.3 | -0.5 |
| Latency to leave start box in cocaine runway, M | 0.2 | 0.2 | 0.5 | -0.3 | -0.6 | 0.7 | 0.5 | 0.7 | -0.3 | -0.1 | -0.3 | -0.1 |
| Co content in liver | 0.2 | 0.2 | 0.5 | 0.2 | 0.7 | -0.7 | -0.6 | 0.5 | -0.1 | 0.2 | 0.2 | 0.2 |
| Fe content in liver | 0.2 | 0.2 | 1.2 | -0.1 | 0.3 | -0.3 | -0.3 | 1.1 | 0.2 | -0.1 | -0.2 | -0.2 |
| BMI with tail | 0.1 | 0.2 | 0.5 | 0.2 | 0.7 | -0.6 | -0.1 | -0.5 | 0.5 | -0.3 | 0.1 | -0.5 |
| Epididymis fat weight | 0.1 | 0.1 | 0.4 | 0.5 | 0.7 | -0.4 | -0.2 | 0.0 | -0.1 | 0.5 | 0.4 | 0.3 |
| Glucose | 0.1 | 0.2 | 0.4 | -0.3 | -0.5 | 0.3 | 0.4 | -0.6 | 0.6 | -0.6 | -0.5 | -0.4 |
| Length without tail | 0.1 | 0.2 | 0.8 | 0.2 | 0.7 | -0.0 | 0.2 | 0.0 | -0.3 | 0.6 | 0.9 | 0.1 |
| Liver weight, left | 0.1 | 0.2 | 0.6 | 0.3 | 0.2 | -0.3 | -0.4 | 0.1 | -0.8 | 0.7 | 0.3 | 0.7 |
| Soleus weight | 0.1 | 0.3 | 1.8 | 0.6 | 0.1 | -0.1 | 0.1 | -1.4 | -0.1 | 0.2 | 0.5 | 0.1 |
| Tibia length | 0.1 | 0.2 | 0.8 | 0.2 | 0.9 | -0.4 | -0.0 | -0.1 | -0.0 | 0.3 | 0.6 | -0.1 |
| Times rat made contact with spout | 0.1 | 0.1 | 0.1 | -0.1 | -0.2 | 0.2 | 0.4 | -0.3 | 0.4 | -0.3 | -0.1 | -0.3 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.2 | -0.1 | -0.3 | 0.2 | 0.3 | -0.4 | 0.1 | -0.2 | -0.2 | -0.3 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.3 | 0.5 | 0.4 | -0.2 | -0.4 | -0.0 | -0.3 | 0.4 | 0.5 | 0.4 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.2 | 0.4 | 0.6 | 0.5 | -0.3 | -0.4 | -0.2 | -0.3 | 0.5 | 0.6 | 0.4 |
| Delay discounting total patch changes 18 sec | 0.1 | 0.1 | 0.1 | -0.0 | -0.3 | 0.3 | 0.3 | 0.2 | 0.3 | -0.2 | -0.2 | -0.4 |
| Delay discounting total patch changes 6 sec | 0.1 | 0.1 | 0.3 | 0.5 | 0.4 | -0.4 | -0.5 | 0.0 | -0.2 | 0.3 | 0.3 | 0.3 |
| Delay discounting time to switch 0 sec | 0.1 | 0.1 | 0.4 | 0.3 | 0.1 | -0.4 | -0.5 | -0.1 | -0.6 | 0.4 | 0.0 | 0.4 |
| Delay discounting water rate 12 sec | 0.1 | 0.1 | 0.2 | -0.2 | -0.4 | 0.5 | 0.4 | 0.1 | 0.1 | -0.4 | -0.1 | -0.2 |
| Reaction time trials on left | 0.1 | 0.2 | 0.5 | 0.3 | 0.7 | -0.5 | -0.2 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Reaction time premature initiations | 0.1 | 0.1 | 0.2 | -0.1 | -0.2 | -0.0 | -0.3 | 0.4 | 0.2 | -0.3 | -0.4 | -0.1 |
| Reaction time trials completed | 0.1 | 0.2 | 0.5 | 0.3 | 0.7 | -0.5 | -0.2 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Reaction time trials AUC | 0.1 | 0.1 | 0.4 | 0.2 | 0.6 | -0.4 | -0.1 | -0.3 | -0.3 | 0.2 | 0.4 | 0.2 |
| Cocaine response before conditioning | 0.1 | 0.1 | 0.4 | 0.4 | 0.6 | -0.2 | -0.1 | 0.0 | -0.2 | 0.5 | 0.6 | 0.3 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | -0.1 | -0.2 | 0.0 | -0.4 | 0.4 | 0.4 | 0.4 |
| Pavlov. Cond. lever latency | 0.1 | 0.2 | 0.5 | 0.4 | 0.7 | -0.6 | -0.5 | 0.3 | -0.3 | 0.4 | 0.3 | 0.4 |
| Pavlov. Cond. index score | 0.1 | 0.1 | 0.2 | -0.1 | -0.5 | 0.4 | 0.4 | -0.3 | 0.3 | -0.3 | -0.1 | -0.4 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | -0.0 | -0.3 | 0.3 | 0.4 | -0.5 | 0.2 | -0.2 | -0.0 | -0.2 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.2 | 0.4 | 0.2 | 0.5 | -0.6 | -0.6 | -0.0 | -0.4 | 0.4 | 0.2 | 0.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.2 | -0.1 | -0.4 | 0.4 | 0.4 | -0.2 | 0.2 | -0.3 | -0.1 | -0.3 |
| Intermitt. access escalation Index | 0.1 | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | -0.4 | 0.0 | -0.2 | 0.2 | 0.3 | 0.3 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.2 | 0.6 | 0.1 | -0.0 | 0.1 | -0.1 | -0.1 | -0.6 | 0.7 | 0.2 | 0.6 |
| Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.5 | 0.1 | -0.0 | 0.2 | 0.1 | -0.3 | -0.7 | 0.5 | 0.4 | 0.4 |
| One hour access (shock baseline) | 0.1 | 0.1 | 0.2 | 0.0 | -0.4 | 0.2 | 0.0 | -0.5 | -0.4 | 0.1 | 0.0 | 0.3 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.2 | 0.3 | -0.3 | -0.4 | 0.6 | 0.5 | 0.3 | 0.3 | -0.4 | -0.3 | -0.4 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.3 | -0.4 | -0.6 | 0.3 | -0.1 | 0.5 | 0.0 | -0.2 | -0.6 | 0.0 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.4 | -0.5 | -0.6 | 0.3 | 0.0 | 0.3 | -0.1 | -0.1 | -0.5 | 0.1 |
| Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.3 | 0.0 | -0.3 | 0.2 | 0.1 | -0.6 | -0.5 | 0.4 | 0.2 | 0.5 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.4 | -0.2 | 0.1 | -0.1 | -0.2 | 0.6 | -0.2 | 0.2 | -0.2 | 0.2 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.3 | 0.5 | 0.2 | -0.2 | -0.2 | -0.3 | -0.2 | 0.1 | 0.4 | 0.1 |
| Time in novel zone, NPP test | 0.1 | 0.1 | 0.3 | 0.4 | 0.3 | -0.4 | -0.6 | -0.2 | -0.4 | 0.4 | 0.3 | 0.4 |
| Bone: cortical area | 0.1 | 0.2 | 0.4 | 0.3 | -0.3 | 0.6 | 0.5 | -0.5 | -0.5 | 0.4 | 0.5 | 0.4 |
| Bone: stiffness | 0.1 | 0.1 | 0.3 | -0.1 | -0.3 | 0.6 | 0.5 | 0.2 | 0.1 | -0.0 | 0.1 | -0.0 |
| Delay disc. indifference point, 4s delay | 0.1 | 0.1 | 0.3 | -0.2 | -0.2 | -0.2 | -0.4 | 0.1 | -0.6 | 0.4 | -0.1 | 0.5 |
| Bouts of movement, locomotor time 1 | 0.1 | 0.1 | 0.3 | 0.2 | 0.4 | -0.4 | -0.3 | -0.2 | -0.3 | 0.6 | 0.4 | 0.3 |
| Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.7 | 0.1 | 0.3 | -0.2 | 0.2 | -0.9 | -0.2 | 0.3 | 0.3 | 0.1 |
| Distance moved, locomotor task time 1 | 0.1 | 0.1 | 0.3 | 0.0 | -0.2 | -0.0 | -0.5 | 0.4 | -0.5 | -0.1 | -0.0 | 0.3 |
| Progressive ratio | 0.1 | 0.2 | 0.6 | 0.0 | -0.2 | 0.0 | -0.0 | -0.8 | -0.6 | 0.4 | 0.1 | 0.5 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.3 | -0.4 | -0.4 | 0.5 | 0.4 | 0.6 | 0.4 | 0.0 | -0.3 | -0.1 |
| Latency to leave start box in cocaine runway | 0.1 | 0.1 | 0.3 | 0.3 | 0.4 | -0.3 | -0.3 | 0.6 | -0.0 | 0.1 | 0.1 | 0.2 |
| Cu content in liver | 0.1 | 0.1 | 0.6 | 0.0 | 0.2 | -0.4 | -0.5 | 0.8 | -0.2 | -0.0 | -0.1 | 0.0 |
| Parametrial fat weight | 0.0 | 0.1 | 0.3 | 0.1 | -0.5 | 0.5 | 0.3 | -0.2 | -0.1 | -0.1 | -0.2 | -0.1 |
| Retroperitoneal fat weight | 0.0 | 0.1 | 0.5 | 0.4 | 0.3 | -0.0 | -0.0 | 0.7 | 0.4 | 0.0 | 0.1 | -0.1 |
| Delay discounting water rate 0 sec | 0.0 | 0.0 | 0.1 | 0.3 | 0.3 | -0.2 | -0.1 | 0.1 | 0.1 | 0.0 | 0.3 | -0.0 |
| Delay discounting water rate 24 sec | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | 0.0 | -0.1 | -0.0 | -0.0 |
| Light reinforcement 2 | 0.0 | 0.1 | 0.2 | -0.1 | -0.4 | 0.3 | -0.0 | 0.3 | -0.1 | -0.3 | -0.2 | 0.0 |
| Std. dev. reaction times | 0.0 | 0.1 | 0.3 | -0.1 | -0.3 | 0.4 | 0.5 | -0.2 | -0.1 | 0.1 | 0.0 | 0.0 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.1 | 0.3 | 0.3 | -0.2 | -0.1 | -0.2 | -0.1 | 0.2 | 0.3 | 0.0 |
| Intermittent access total infusions | 0.0 | 0.0 | 0.2 | -0.0 | -0.2 | 0.2 | 0.0 | -0.1 | -0.4 | 0.3 | 0.1 | 0.2 |
| Locomotion velocity, session 2 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | -0.0 | -0.1 | 0.4 | -0.2 | 0.0 | 0.0 | 0.1 |
| Locomotion distance, session 2 | 0.0 | 0.1 | 0.1 | 0.3 | 0.2 | -0.1 | -0.1 | -0.4 | -0.4 | 0.3 | 0.3 | 0.3 |
| Delta time in closed arm before/after self-admin | 0.0 | 0.0 | 0.1 | -0.3 | 0.2 | -0.0 | 0.2 | 0.4 | 0.0 | -0.0 | -0.1 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.