Hub : Genes

Krt86

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000008367 0.03 0.02 1.1e-03 0.01 0.01 0 0 5.2e-02 5.1e-02 2.2e-01 7.6e-02
2 BLA gene expression ENSRNOG00000008367 0.08 0.05 2.2e-05 0.11 0.07 0.09 0.08 1.6e-06 8.0e-05 1.4e-05 4.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail1.75.57.72.8-1.8
BMI without tail0.20.40.80.9-0.2
Body weight0.31.32.31.5-0.5
Epididymis fat weight4.19.510.9-2.93.3
Glucose0.20.20.4-0.30.6
Heart weight0.00.00.0-0.0-0.1
Left kidney weight0.00.10.20.4-0.2
Right kidney weight0.20.70.80.9-0.7
Tail length0.31.01.3-0.91.1
Length with tail0.20.61.1-0.41.0
Length without tail0.00.10.10.3-0.0
Liver weight, left0.10.10.2-0.50.2
Liver weight, right0.10.20.4-0.60.2
Parametrial fat weight2.85.55.6-2.42.3
Retroperitoneal fat weight1.75.56.5-2.52.1
Intraocular pressure0.40.60.9-1.0-0.4
Extensor digitorum longus weight6.626.631.05.6-4.7
Soleus weight0.00.00.00.1-0.1
Tibialis anterior weight9.532.638.96.2-5.1
Tibia length0.00.10.10.1-0.3
Number of licking bursts0.20.20.40.3-0.6
Food consumed during 24 hour testing period0.60.70.9-1.00.6
Times rat made contact with spout0.50.50.7-0.80.6
Mean time between licks in bursts0.71.01.2-1.10.8
Mean num. licks in bursts1.21.41.6-1.11.3
Std. dev. time between licks in bursts1.31.51.6-1.31.2
Water consumed over 24 hours0.70.81.3-1.10.6
Indifference point 0 sec0.10.20.4-0.60.2
Indifference point AUC0.40.50.50.7-0.7
Indifference point function ln k0.10.10.20.00.4
Indifference point function log k0.10.10.20.00.4
Delay discounting total patch changes 0 sec0.40.71.0-1.00.7
Delay discounting total patch changes 12 sec0.00.10.1-0.2-0.3
Delay discounting total patch changes 18 sec0.10.20.3-0.6-0.2
Delay discounting total patch changes 24 sec0.30.40.8-0.0-0.9
Delay discounting total patch changes 6 sec0.10.10.1-0.3-0.3
Delay discounting time to switch 0 sec0.10.20.20.5-0.3
Delay discounting water rate 0 sec0.00.00.0-0.1-0.0
Delay discounting water rate 12 sec0.50.80.9-0.90.9
Delay discounting water rate 18 sec0.00.00.00.1-0.2
Delay discounting water rate 24 sec0.30.50.60.6-0.8
Delay discounting water rate 6 sec0.10.10.2-0.50.2
Locomotor activity0.10.10.2-0.40.1
Locomotor testing distance0.50.81.1-1.10.7
Locomotor testing rearing0.50.70.9-0.90.8
Light reinforcement 10.00.10.2-0.1-0.4
Light reinforcement 20.10.10.2-0.10.5
Reaction time number correct0.60.91.1-0.81.1
Reaction time mean minus median0.00.00.0-0.1-0.0
Reaction time mean minus median AUC0.10.10.20.3-0.5
Reaction time num false alarms0.20.30.6-0.30.8
Reaction time num false alarms AUC0.10.10.2-0.10.5
Reaction time trials correct on left0.60.91.1-0.81.1
Reaction time trials on left0.71.01.3-0.91.2
Reaction time mean0.10.10.10.2-0.3
Reaction time mean AUC0.10.10.10.3-0.3
Median of all reaction times0.10.10.10.2-0.4
Reaction time omissions1.62.12.7-1.21.6
Reaction time false alarm rate0.20.30.40.6-0.4
Reaction time premature initiation rate0.81.11.7-1.30.6
Reaction time premature initiations1.52.12.8-1.71.2
Std. dev. reaction times0.00.00.00.1-0.2
Reaction time trials completed0.71.01.3-0.91.2
Reaction time trials AUC0.50.71.0-0.71.0
Social response proportion1.71.92.0-1.41.3
Social responses0.60.81.2-0.61.1
Social time2.02.63.5-1.31.9
Conditioned locomotion0.40.40.8-0.30.9
Cocaine response after cond. corrected0.10.10.20.40.3
Cocaine response after cond. not corrected0.10.10.20.10.4
Cocaine response before conditioning0.80.91.6-1.30.5
Saline control response0.00.00.0-0.2-0.2
Condit. Reinf. active minus inactive responses1.41.72.01.2-1.4
Condit. Reinf. active-inactive response ratio0.50.50.70.6-0.8
Condit. Reinf. active responses1.72.33.11.2-1.8
Condit. Reinf. inactive responses0.30.40.50.5-0.7
Condit. Reinf. lever presses0.20.30.5-0.70.2
Condit. Reinf. lever reinforcers received0.70.91.50.7-1.2
Pavlov. Cond. lever latency0.81.11.51.2-0.8
Pavlov. Cond. magazine entry latency3.23.74.3-1.72.1
Pavlov. Cond. change in total contacts1.01.41.51.2-1.2
Pavlov. Cond. index score1.52.02.0-1.41.4
Pavlov. Cond. latency score1.41.71.7-1.31.3
Pavlov. Cond. lever contacts1.62.22.6-1.61.3
Pavlov. Cond. magazine entry number0.81.01.10.9-1.1
Pavlov. Cond. intertrial magazine entries0.81.01.3-1.10.8
Pavlov. Cond. lever-magazine prob. diff.1.01.31.4-1.11.2
Pavlov. Cond. response bias1.72.32.8-1.71.3
Conditioned reinforcement - actives0.90.91.50.5-1.2
Conditioned reinforcement - inactives0.00.00.0-0.10.1
Conditioned locomotion0.20.30.5-0.3-0.7
Intermittent access intake day 1-15 change0.40.40.8-0.90.2
Intermittent access intake escalation0.40.40.8-0.9-0.2
Intermittent access intake escalation 20.30.30.6-0.8-0.0
Intermitt. access day 1 inactive lever presses0.10.10.2-0.0-0.5
Intermitt. access day 15 inactive lever presses0.70.70.8-0.80.9
Intermitt. access escalation Index2.72.43.71.1-1.9
Intermittent access day 1 total infusions0.30.40.80.1-0.9
Intermittent access day 15 total infusions0.30.30.3-0.6-0.5
Intermittent access terminal intake (last 3 days)1.01.12.30.0-1.5
Intermittent access total infusions1.21.42.70.1-1.6
Intermittent access day 1 locomotion0.30.30.4-0.6-0.5
Intermittent access day 15 total locomotion0.91.01.9-1.40.3
Intermittent access total locomotion0.50.60.6-0.7-0.8
Intermittent access standard deviation1.21.31.6-1.31.0
Cocaine induced anxiety0.10.20.2-0.3-0.5
Post-drug Anxiety1.01.11.90.6-1.4
Baseline Anxiety0.00.00.00.20.0
Lifetime Intake1.01.12.1-0.3-1.4
Incentive Sensitization - Responses0.40.40.50.5-0.7
Incentive Sensitization - Breakpoint0.70.70.80.7-0.9
Progressive ratio test 1 active lever presses0.60.60.7-0.9-0.7
Progressive ratio test 1 breakpoint0.50.50.5-0.7-0.7
Progressive ratio test 1 inactive lever presses0.30.30.6-0.1-0.8
Progressive ratio test 2 active lever presses0.80.81.6-0.2-1.3
Progressive ratio test 2 breakpoint0.70.81.6-0.2-1.2
Progressive ratio test 2 inactive lever presses0.30.30.3-0.6-0.6
Total sessions with >9 infusions2.02.24.30.3-2.1
Short access day 1 total inactive lever presses0.20.20.2-0.4-0.5
Short access day 10 total inactive lever presses0.10.10.1-0.40.2
Short access day 1 total infusions0.10.10.2-0.2-0.4
Short access day 10 total infusions0.50.61.1-0.3-1.1
Short access total infusions0.50.60.9-0.5-0.9
Short access day 1 locomotion0.00.00.1-0.20.3
Short access day 10 total locomotion0.00.00.0-0.10.1
Short access total locomotion0.00.00.1-0.1-0.3
Compulsive drug intake2.72.73.81.3-1.9
One hour access (0.3 mA shock)3.23.76.11.1-2.5
One hour access (shock baseline)1.11.32.10.7-1.4
Number of responses in last shaping day1.41.42.7-0.41.6
Context. condit. distance diff. score0.10.20.30.0-0.6
Locomotion velocity, session 14.24.55.4-1.92.3
Locomotion distance, session 10.81.01.6-0.71.3
Locomotion velocity, session 23.74.46.0-1.72.5
Locomotion distance, session 20.91.31.7-0.91.3
Locomotion velocity, session 34.45.15.2-2.32.3
Locomotion distance, session 33.94.25.0-2.21.8
Stereotopy head waving bouts, day 31.72.02.51.6-1.2
Stereotopy head waving duration, day 30.10.10.10.4-0.0
Locomotion velocity, session 70.50.61.1-1.00.2
Locomotion distance, session 72.93.74.7-2.21.6
Stereotopy head waving bouts, day 73.43.84.52.1-1.8
Stereotopy head waving duration, day 73.03.64.22.1-1.7
Locomotion velocity, session 80.00.00.0-0.1-0.1
Locomotion distance, session 81.01.41.6-1.31.1
Degree of sensitization distance0.30.30.40.7-0.5
Degree of sensitization stereotypy3.23.53.61.9-1.9
Condit. Reinf. active minus inactive responses0.30.40.6-0.30.8
Condit. Reinf. active-inactive response ratio0.70.70.9-0.71.0
Condit. Reinf. active responses0.81.01.6-0.61.3
Condit. Reinf. inactive responses0.50.61.1-0.51.0
Incentive salience index mean0.10.10.10.00.4
Condit. Reinf. lever presses0.50.60.91.0-0.6
Time in familiar zone, hab. session 10.70.70.9-0.61.0
Time in novel zone, hab. session 12.52.42.71.4-1.6
Total zone transitions, hab. session 10.50.71.01.0-0.7
Total locomotion distance, hab. session 10.30.40.6-0.40.8
Locomotion velocity, hab. session 10.40.61.0-0.51.0
Time in familiar zone, hab. session 20.10.10.1-0.40.3
Time in novel zone, hab. session 20.80.80.80.8-0.9
Total zone transitions, hab. session 20.20.30.3-0.50.6
Total locomotion distance, hab. session 20.70.91.3-0.61.2
Locomotion velocity, hab. session 21.01.42.1-0.91.4
Novel to familiar place preference ratio0.91.01.51.2-0.7
Novelty place preference0.70.71.11.0-0.6
Time in novel zone, NPP test0.90.91.31.2-0.8
Total zone transitions, NPP test0.60.91.2-0.71.1
Total locomotion distance, NPP test2.33.34.2-1.52.0
Locomotion velocity, NPP test2.84.05.2-1.72.3
Pavlov. Cond. lever latency2.02.63.2-1.41.8
Pavlov. Cond. magazine entry latency3.74.75.42.0-2.3
Pavlov. Cond. change in total contacts4.14.45.02.0-2.2
Pavlov. Cond. index score4.65.96.82.2-2.6
Pavlov. Cond. latency score4.45.76.82.1-2.6
Pavlov. Cond. lever contacts1.92.22.91.3-1.7
Pavlov. Cond. magazine entry number1.82.32.9-1.31.7
Pavlov. Cond. intertrial magazine entries1.82.22.2-1.51.5
Pavlov. Cond. lever-magazine prob. diff.4.65.76.82.2-2.6
Pavlov. Cond. response bias1.82.32.81.3-1.7
Bone: apparent density0.00.00.10.3-0.1
Bone surface0.30.50.70.6-0.8
Bone volume0.40.70.70.8-0.8
Bone: connectivity density0.10.20.2-0.40.4
Bone: cortical apparent density1.01.32.01.4-0.7
Bone: cortical area0.40.70.70.8-0.8
Bone: cortical porosity1.61.71.8-1.31.3
Bone: cortical porosity1.51.61.7-1.21.3
Bone: cortical thickness0.10.10.10.4-0.2
Bone: cortical thickness1.41.62.4-0.91.6
Bone: cortical tissue density0.81.01.71.3-0.6
Bone: elastic displacement4.55.15.5-2.32.2
Bone: elastic work3.74.95.5-2.02.4
Bone: endosteal estimation0.40.91.10.8-1.1
Bone: endosteal perimeter0.81.61.61.3-1.3
Bone: final force0.00.00.10.2-0.2
Bone: final moment0.00.10.10.2-0.3
Bone: marrow area0.40.91.20.8-1.1
Bone: maximum diameter0.61.21.50.9-1.2
Bone: maximum force0.40.70.80.8-0.9
Bone: maximum moment0.40.70.80.8-0.9
Bone: minimum diameter0.71.31.41.1-1.2
Bone: periosteal estimation0.61.21.61.0-1.2
Bone: periosteal perimeter1.72.83.11.8-1.6
Bone: post-yield work0.50.60.90.6-1.0
Bone: stiffness1.82.93.11.7-1.7
Bone: tissue strength1.31.31.61.0-1.3
Bone: trabecular number0.30.40.4-0.60.6
Bone: trabecular spacing1.21.52.20.9-1.5
Bone: trabecular thickness0.10.10.10.30.3
Bone: trabecular tissue density2.12.93.61.9-1.5
Breakpoint value in progressive ratio session0.91.02.10.0-1.4
Distance traveled before self-admin0.10.10.2-0.1-0.5
Distance traveled after self-admin0.40.50.9-1.0-0.1
Delta time in closed arm before/after self-admin0.20.20.40.1-0.6
Delta time in open arm before/after self-admin6.05.76.5-2.22.6
Diff in mean of infusions in LGA sessions0.50.51.11.0-0.2
Extinction: sum of active levers before priming0.90.90.90.9-1.0
Active lever presses in extinction session 60.00.00.1-0.1-0.3
Delta distance traveled before/after self-admin2.22.42.9-1.71.4
Delta ambulatory time before/after self-admin1.92.12.8-1.71.1
Time in closed arm before self-admin0.40.51.01.0-0.2
Time in closed arm after self-admin3.03.13.81.6-1.9
Time in open arm before self-admin3.63.84.71.7-2.2
Time in open arm after self-admin0.91.01.7-0.51.3
Sum of active levers in priming session hrs 5-60.70.71.30.2-1.1
Time to tail flick, vehicle, before self-admin0.10.10.20.4-0.3
Time to tail flick, vehicle, after self-admin0.20.20.20.40.5
Time to tail flick, test, before self-admin0.30.30.40.60.4
Time to tail flick, test, after self-admin0.10.10.10.3-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.2-0.30.5
Delta time to tail flick, test, before/after SA0.20.10.3-0.0-0.5
Ambulatory time before self-admin0.20.20.4-0.4-0.6
Ambulatory time after self-admin0.80.91.8-1.3-0.1
Total heroin consumption0.20.20.3-0.4-0.6
Area under the delay curve0.10.10.10.3-0.2
Delay disc. indifference point, 0s delay0.10.10.10.10.3
Delay disc. indifference point, 16s delay0.10.10.10.2-0.2
Delay disc. indifference point, 2s delay6.06.77.22.7-2.5
Delay disc. indifference point, 24s delay0.00.00.10.2-0.2
Delay disc. indifference point, 4s delay0.20.20.30.4-0.5
Delay disc. indifference point, 8s delay0.10.10.1-0.40.3
Delay discount exponential model param0.10.20.2-0.40.4
Delay discount hyperbolic model param0.40.50.5-0.70.7
Fecal boli incidents, locomotor time 13.74.04.2-2.01.9
Change in fecal boli incidents, locomotor task1.11.11.31.2-0.9
Time >=10cm from walls, locomotor time 10.20.20.3-0.50.4
Bouts of movement, locomotor time 10.10.10.1-0.40.1
Total resting periods, locomotor time 10.50.60.6-0.80.7
Rest time, locomotor task time 10.40.50.5-0.70.7
Distance moved, locomotor task time 11.31.52.10.9-1.5
Vertical activity count, locomotor time 12.72.83.31.5-1.8
Time >=10cm from walls, locomotor time 20.10.20.3-0.6-0.0
Bouts of movement, locomotor time 22.62.73.81.3-1.9
Total resting periods, locomotor time 23.03.23.91.6-2.0
Rest time, locomotor task time 20.30.30.60.10.8
Distance moved, locomotor task time 20.00.00.1-0.0-0.2
Vertical activity count, locomotor time 20.30.30.50.2-0.7
Weight adjusted by age0.40.50.60.60.8
Seeking ratio, delayed vs. immediate footshock0.00.00.00.20.1
Locomotion in novel chamber1.72.22.31.5-1.4
Locomotion in novel chamber post-restriction1.51.73.40.1-1.9
Progressive ratio0.10.10.1-0.3-0.3
Food seeking constrained by brief footshock1.01.22.4-0.2-1.5
Seeking ratio, punishment vs. effort0.10.10.20.0-0.4
Run reversals in cocaine runway, females0.00.00.0-0.1-0.1
Run reversals in cocaine runway, males0.90.91.71.3-0.2
Latency to leave start box in cocaine runway0.40.40.50.6-0.7
Latency to leave start box in cocaine runway, F0.30.30.40.7-0.5
Latency to leave start box in cocaine runway, M0.60.60.90.5-1.0
Cd content in liver0.10.10.3-0.50.1
Co content in liver0.10.10.2-0.0-0.5
Cu content in liver2.02.44.50.6-2.1
Fe content in liver0.10.10.2-0.4-0.0
K content in liver0.10.10.2-0.50.3
Mg content in liver0.10.20.3-0.50.1
Mn content in liver0.00.00.10.10.2
Na content in liver0.10.10.20.0-0.4
Rb content in liver0.40.61.0-0.4-1.0
Se content in liver0.40.50.5-0.70.7
Sr content in liver1.71.51.6-1.31.2
Zn content in liver1.01.11.5-1.20.9