Hub : Genes

tGap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	isoform ratio	ENSRNOT00000033404	0.44	0.17	2.5e-04	-0.01	0.09	0.05	0.06	7.2e-01	4.7e-03	2.6e-02	1.3e-02
2	OFC	isoform ratio	ENSRNOT00000082912	0.48	0.17	7.1e-05	0.03	0.11	0.06	0.08	7.0e-02	1.5e-03	1.4e-02	5.4e-03
3	PL	isoform ratio	ENSRNOT00000082912	0.06	0.04	5.6e-03	0.02	0.01	0.01	0.01	2.1e-02	2.6e-02	3.4e-02	5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.9	2.9	3.3	1.8	-1.8	-1.5
BMI without tail	1.6	3.4	4.3	1.7	-1.7	-2.1
Body weight	0.4	1.9	2.2	1.5	-1.5	-1.1
Epididymis fat weight	0.3	0.8	1.3	-1.1	1.0	-0.2
Glucose	0.7	1.1	1.2	1.1	-1.1	-1.0
Heart weight	0.8	1.2	1.4	-1.2	1.2	0.9
Left kidney weight	1.3	3.7	4.4	-2.1	2.1	1.5
Right kidney weight	1.6	4.5	5.3	-2.3	2.3	1.7
Tail length	0.1	0.2	0.5	0.2	-0.2	-0.7
Length with tail	0.0	0.0	0.0	0.2	-0.2	-0.1
Length without tail	0.1	0.2	0.6	0.2	-0.1	0.7
Liver weight, left	2.5	4.1	4.8	1.9	-2.0	-2.2
Liver weight, right	0.0	0.0	0.1	-0.2	0.2	-0.2
Parametrial fat weight	0.2	0.4	1.1	-0.1	0.0	-1.1
Retroperitoneal fat weight	0.1	0.2	0.3	-0.6	0.5	0.2
Intraocular pressure	2.7	3.8	4.5	2.1	-2.1	-1.5
Extensor digitorum longus weight	8.9	35.6	47.2	5.4	-5.6	-6.9
Soleus weight	1.1	3.1	4.3	1.5	-1.6	-2.1
Tibialis anterior weight	7.2	24.7	26.9	4.8	-4.9	-5.2
Tibia length	1.7	4.7	4.8	-2.1	2.2	2.2
Number of licking bursts	0.6	0.7	1.7	-0.4	0.5	1.3
Food consumed during 24 hour testing period	2.1	2.5	2.7	1.6	-1.7	-1.5
Times rat made contact with spout	0.0	0.0	0.1	-0.2	0.2	0.2
Mean time between licks in bursts	1.7	2.4	3.0	1.7	-1.7	-1.0
Mean num. licks in bursts	0.3	0.3	0.9	0.2	-0.3	-1.0
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	-0.3	0.4
Water consumed over 24 hours	0.2	0.2	0.3	0.5	-0.5	-0.3
Indifference point 0 sec	1.7	2.8	3.0	-1.7	1.7	1.6
Indifference point AUC	0.1	0.1	0.1	-0.4	0.4	0.1
Indifference point function ln k	0.2	0.2	0.6	0.2	-0.2	-0.8
Indifference point function log k	0.2	0.2	0.6	0.2	-0.2	-0.8
Delay discounting total patch changes 0 sec	1.5	2.4	2.8	-1.7	1.7	1.3
Delay discounting total patch changes 12 sec	2.4	3.2	3.3	-1.8	1.8	1.8
Delay discounting total patch changes 18 sec	0.1	0.1	0.1	-0.4	0.3	-0.1
Delay discounting total patch changes 24 sec	1.1	1.4	1.7	-1.3	1.3	0.9
Delay discounting total patch changes 6 sec	0.4	0.7	0.9	-0.9	0.9	0.5
Delay discounting time to switch 0 sec	3.8	5.8	6.7	2.6	-2.6	-2.0
Delay discounting water rate 0 sec	1.0	1.6	1.8	-1.4	1.4	1.0
Delay discounting water rate 12 sec	1.2	1.9	2.0	-1.3	1.4	1.4
Delay discounting water rate 18 sec	0.5	0.6	1.2	-0.5	0.6	1.1
Delay discounting water rate 24 sec	0.9	1.2	1.8	-1.3	1.3	0.4
Delay discounting water rate 6 sec	1.4	2.0	2.8	-1.2	1.3	1.7
Locomotor activity	0.1	0.1	0.2	0.2	-0.2	-0.4
Locomotor testing distance	0.2	0.3	0.3	0.6	-0.6	-0.6
Locomotor testing rearing	0.3	0.5	0.6	-0.7	0.7	0.7
Light reinforcement 1	0.2	0.4	1.0	0.1	-0.2	-1.0
Light reinforcement 2	1.6	2.1	3.9	1.0	-1.1	-2.0
Reaction time number correct	0.1	0.2	0.2	0.5	-0.4	0.4
Reaction time mean minus median	3.1	4.0	7.9	1.4	-1.5	-2.8
Reaction time mean minus median AUC	3.9	5.0	8.8	1.7	-1.8	-3.0
Reaction time num false alarms	0.4	0.6	1.7	0.1	-0.0	1.3
Reaction time num false alarms AUC	0.4	0.5	1.6	0.0	0.1	1.3
Reaction time trials correct on left	0.1	0.2	0.2	0.5	-0.4	0.4
Reaction time trials on left	0.2	0.2	0.3	0.6	-0.5	0.3
Reaction time mean	3.8	5.2	6.1	2.1	-2.2	-2.5
Reaction time mean AUC	4.2	5.7	6.6	2.2	-2.3	-2.6
Median of all reaction times	3.6	4.9	5.3	2.3	-2.3	-2.1
Reaction time omissions	2.4	3.2	5.2	1.4	-1.5	-2.3
Reaction time false alarm rate	0.2	0.2	0.4	-0.4	0.4	0.6
Reaction time premature initiation rate	2.0	2.7	2.8	-1.6	1.6	1.7
Reaction time premature initiations	1.3	1.8	2.5	-1.2	1.2	1.6
Std. dev. reaction times	2.0	2.7	5.2	1.1	-1.2	-2.3
Reaction time trials completed	0.2	0.2	0.3	0.6	-0.5	0.3
Reaction time trials AUC	0.2	0.3	0.4	0.7	-0.6	0.2
Social response proportion	0.2	0.2	0.6	-0.1	0.0	-0.8
Social responses	0.4	0.5	1.6	0.0	-0.1	-1.3
Social time	0.1	0.1	0.2	0.4	-0.4	-0.4
Conditioned locomotion	0.2	0.2	0.3	0.4	-0.4	-0.5
Cocaine response after cond. corrected	1.3	1.4	1.9	-1.1	1.1	1.4
Cocaine response after cond. not corrected	2.3	2.5	3.5	-1.4	1.5	1.9
Cocaine response before conditioning	0.1	0.1	0.3	-0.1	0.1	0.6
Saline control response	0.5	0.6	0.8	0.9	-0.8	0.7
Condit. Reinf. active minus inactive responses	0.9	1.2	2.9	0.6	-0.4	1.7
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.5	0.6	-0.5	1.2
Condit. Reinf. active responses	1.0	1.4	3.9	0.4	-0.3	2.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	-0.2	0.1
Condit. Reinf. lever presses	0.4	0.5	1.2	0.5	-0.4	1.1
Condit. Reinf. lever reinforcers received	1.1	1.6	4.6	0.3	-0.1	2.1
Pavlov. Cond. lever latency	0.9	1.2	2.2	0.8	-0.9	-1.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	-0.0
Pavlov. Cond. change in total contacts	0.6	0.9	1.4	1.2	-1.1	0.3
Pavlov. Cond. index score	0.2	0.3	0.3	0.5	-0.5	0.5
Pavlov. Cond. latency score	0.1	0.2	0.5	0.2	-0.1	0.7
Pavlov. Cond. lever contacts	0.4	0.5	1.2	-0.4	0.4	1.1
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.7	0.7	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.6	0.7	0.8	-0.8	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.4	-0.4	0.6
Pavlov. Cond. response bias	0.2	0.3	0.7	0.3	-0.2	0.8
Conditioned reinforcement - actives	1.2	1.2	2.3	-0.7	0.8	1.5
Conditioned reinforcement - inactives	0.2	0.2	0.2	0.4	-0.4	-0.5
Conditioned locomotion	0.6	0.7	1.7	-0.4	0.5	1.3
Intermittent access intake day 1-15 change	6.1	6.1	6.2	-2.5	2.5	2.4
Intermittent access intake escalation	4.6	4.6	4.7	-2.1	2.1	2.2
Intermittent access intake escalation 2	5.3	5.2	7.3	-2.0	2.1	2.7
Intermitt. access day 1 inactive lever presses	0.8	0.8	2.2	-0.4	0.3	-1.5
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.5	-1.2	1.1	-0.7
Intermitt. access escalation Index	0.0	0.0	0.1	0.1	-0.1	-0.3
Intermittent access day 1 total infusions	0.4	0.5	1.2	-0.4	0.4	1.1
Intermittent access day 15 total infusions	3.9	4.4	6.2	-1.8	1.9	2.5
Intermittent access terminal intake (last 3 days)	5.5	6.0	8.4	-2.2	2.3	2.9
Intermittent access total infusions	2.6	2.9	4.2	-1.5	1.5	2.0
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.3	0.3	0.5
Intermittent access day 15 total locomotion	0.8	0.9	1.9	-0.6	0.6	1.4
Intermittent access total locomotion	1.0	1.1	1.4	-1.0	1.0	1.2
Intermittent access standard deviation	5.6	6.0	7.0	-2.6	2.6	2.0
Cocaine induced anxiety	0.2	0.2	0.5	-0.2	0.1	-0.7
Post-drug Anxiety	1.5	1.6	3.7	0.7	-0.8	-1.9
Baseline Anxiety	0.1	0.1	0.2	0.5	-0.5	-0.1
Lifetime Intake	3.1	3.5	4.4	-1.7	1.8	2.1
Incentive Sensitization - Responses	0.4	0.4	0.8	0.5	-0.4	0.9
Incentive Sensitization - Breakpoint	0.4	0.4	0.9	0.4	-0.3	0.9
Progressive ratio test 1 active lever presses	3.6	3.8	4.8	-2.2	2.2	1.4
Progressive ratio test 1 breakpoint	3.6	3.8	4.6	-2.1	2.1	1.5
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	-0.9	0.8	-0.3
Progressive ratio test 2 active lever presses	1.8	1.9	2.7	-1.2	1.2	1.6
Progressive ratio test 2 breakpoint	1.3	1.5	2.6	-0.9	1.0	1.6
Progressive ratio test 2 inactive lever presses	0.7	0.9	0.9	-0.9	0.9	0.9
Total sessions with >9 infusions	2.2	2.4	2.9	-1.7	1.7	1.2
Short access day 1 total inactive lever presses	0.5	0.5	0.8	-0.9	0.9	0.3
Short access day 10 total inactive lever presses	0.4	0.4	0.5	-0.6	0.5	-0.7
Short access day 1 total infusions	3.1	3.3	3.4	-1.8	1.8	1.9
Short access day 10 total infusions	2.4	2.7	2.9	-1.7	1.7	1.5
Short access total infusions	3.3	3.6	3.7	-1.9	1.9	1.9
Short access day 1 locomotion	0.9	1.0	1.3	-1.2	1.1	0.6
Short access day 10 total locomotion	0.2	0.3	0.8	0.0	-0.1	-0.9
Short access total locomotion	0.6	0.6	0.8	-0.9	0.9	0.4
Compulsive drug intake	2.2	2.2	3.1	1.3	-1.3	-1.8
One hour access (0.3 mA shock)	2.1	2.4	4.6	-1.1	1.2	2.1
One hour access (shock baseline)	5.1	5.9	8.5	-2.1	2.2	2.9
Number of responses in last shaping day	0.4	0.5	0.7	-0.8	0.8	0.3
Context. condit. distance diff. score	0.1	0.2	0.2	-0.5	0.4	-0.2
Locomotion velocity, session 1	1.7	1.8	2.9	1.1	-1.1	-1.7
Locomotion distance, session 1	2.3	3.0	3.3	1.8	-1.8	-1.5
Locomotion velocity, session 2	1.4	1.7	2.3	1.1	-1.2	-1.5
Locomotion distance, session 2	2.1	3.0	3.5	1.9	-1.9	-1.4
Locomotion velocity, session 3	0.1	0.1	0.3	0.1	-0.2	-0.5
Locomotion distance, session 3	0.4	0.4	0.6	0.8	-0.7	-0.2
Stereotopy head waving bouts, day 3	0.4	0.4	0.6	0.8	-0.7	-0.4
Stereotopy head waving duration, day 3	0.6	0.7	1.2	0.7	-0.7	-1.1
Locomotion velocity, session 7	0.9	0.9	2.8	0.2	-0.1	1.7
Locomotion distance, session 7	1.5	1.9	4.1	-0.9	1.0	2.0
Stereotopy head waving bouts, day 7	0.9	1.0	1.1	1.0	-1.0	-1.0
Stereotopy head waving duration, day 7	0.6	0.8	1.5	0.6	-0.6	-1.2
Locomotion velocity, session 8	1.9	2.3	4.3	1.1	-1.1	-2.1
Locomotion distance, session 8	1.1	1.7	2.6	1.1	-1.1	-1.6
Degree of sensitization distance	1.1	1.1	1.7	-0.8	0.9	1.3
Degree of sensitization stereotypy	1.0	1.1	1.8	0.8	-0.9	-1.3
Condit. Reinf. active minus inactive responses	6.5	7.2	8.6	2.9	-2.9	-2.1
Condit. Reinf. active-inactive response ratio	8.2	8.9	10.5	3.2	-3.2	-2.4
Condit. Reinf. active responses	5.9	7.2	8.7	2.9	-2.9	-2.1
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.5	-0.5	-0.6
Incentive salience index mean	7.5	9.0	10.5	3.2	-3.2	-2.4
Condit. Reinf. lever presses	3.2	4.3	4.8	2.2	-2.2	-1.8
Time in familiar zone, hab. session 1	0.4	0.4	0.6	-0.8	0.7	-0.2
Time in novel zone, hab. session 1	0.2	0.1	0.3	-0.2	0.2	0.6
Total zone transitions, hab. session 1	2.2	3.1	3.6	1.9	-1.9	-1.4
Total locomotion distance, hab. session 1	1.6	2.2	3.0	1.7	-1.7	-0.9
Locomotion velocity, hab. session 1	2.0	2.9	3.7	1.9	-1.9	-1.2
Time in familiar zone, hab. session 2	2.1	2.2	3.1	-1.8	1.7	0.7
Time in novel zone, hab. session 2	0.9	0.9	1.5	1.2	-1.2	-0.1
Total zone transitions, hab. session 2	0.6	0.8	1.7	0.6	-0.7	-1.3
Total locomotion distance, hab. session 2	0.5	0.7	0.8	0.8	-0.8	-0.9
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.6	-0.6	-0.8
Novel to familiar place preference ratio	0.0	0.0	0.1	0.0	-0.0	0.3
Novelty place preference	0.1	0.1	0.2	-0.2	0.2	0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	0.4	0.4
Total zone transitions, NPP test	1.5	2.2	3.3	1.2	-1.3	-1.8
Total locomotion distance, NPP test	1.4	2.0	2.3	1.5	-1.5	-1.1
Locomotion velocity, NPP test	1.0	1.4	1.8	1.3	-1.3	-0.8
Pavlov. Cond. lever latency	1.1	1.5	1.7	-1.3	1.3	1.0
Pavlov. Cond. magazine entry latency	0.7	0.9	1.2	1.1	-1.1	-0.5
Pavlov. Cond. change in total contacts	2.4	2.6	3.1	1.8	-1.8	-1.2
Pavlov. Cond. index score	1.1	1.4	1.5	1.2	-1.2	-1.1
Pavlov. Cond. latency score	1.0	1.3	1.4	1.2	-1.2	-1.1
Pavlov. Cond. lever contacts	1.7	2.0	2.6	1.6	-1.6	-0.9
Pavlov. Cond. magazine entry number	0.7	0.8	0.9	-1.0	1.0	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.1	-0.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	1.5	1.2	-1.2	-1.0
Pavlov. Cond. response bias	1.2	1.4	1.9	1.4	-1.4	-0.7
Bone: apparent density	0.7	1.1	3.2	-0.2	0.3	1.8
Bone surface	1.2	2.2	6.5	0.0	0.2	2.5
Bone volume	1.1	1.9	5.5	0.2	-0.0	2.4
Bone: connectivity density	0.8	1.2	3.1	-0.5	0.6	1.8
Bone: cortical apparent density	0.8	1.1	2.2	0.7	-0.8	-1.5
Bone: cortical area	0.2	0.3	0.4	0.6	-0.5	0.6
Bone: cortical porosity	0.1	0.1	0.1	0.4	-0.3	0.3
Bone: cortical porosity	0.2	0.2	0.3	0.5	-0.5	0.0
Bone: cortical thickness	0.6	0.9	1.4	1.2	-1.1	-0.2
Bone: cortical thickness	1.0	1.2	1.3	1.1	-1.2	-1.0
Bone: cortical tissue density	0.8	1.1	2.3	0.7	-0.7	-1.5
Bone: elastic displacement	0.9	1.1	1.5	1.2	-1.2	-0.5
Bone: elastic work	0.4	0.5	0.7	0.9	-0.8	0.1
Bone: endosteal estimation	0.3	0.7	1.8	0.5	-0.4	1.4
Bone: endosteal perimeter	0.4	0.7	1.8	-0.4	0.5	1.3
Bone: final force	0.1	0.2	0.4	0.4	-0.3	0.6
Bone: final moment	0.2	0.3	1.0	0.1	-0.0	1.0
Bone: marrow area	0.3	0.7	1.5	0.6	-0.5	1.2
Bone: maximum diameter	0.3	0.5	0.9	-0.5	0.5	0.9
Bone: maximum force	0.2	0.3	0.5	0.4	-0.3	0.7
Bone: maximum moment	0.2	0.4	1.2	0.1	-0.0	1.1
Bone: minimum diameter	1.7	3.1	5.0	2.2	-2.1	-0.0
Bone: periosteal estimation	0.5	1.1	1.2	1.1	-0.9	1.1
Bone: periosteal perimeter	0.3	0.5	1.4	-0.2	0.3	1.2
Bone: post-yield work	3.1	4.2	6.3	-1.7	1.8	2.5
Bone: stiffness	0.1	0.2	0.5	-0.0	0.1	0.7
Bone: tissue strength	2.8	2.7	2.9	-1.7	1.7	1.6
Bone: trabecular number	0.4	0.6	1.5	-0.3	0.3	1.2
Bone: trabecular spacing	0.6	0.7	2.0	0.3	-0.4	-1.4
Bone: trabecular thickness	1.0	1.2	3.5	0.1	0.1	1.9
Bone: trabecular tissue density	0.8	1.1	2.5	0.6	-0.7	-1.6
Breakpoint value in progressive ratio session	2.3	2.5	3.5	1.4	-1.5	-1.9
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	0.1	-0.3
Distance traveled after self-admin	0.5	0.6	0.9	-1.0	0.9	0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	-0.5	0.4	0.4
Delta time in open arm before/after self-admin	0.4	0.4	0.5	-0.7	0.7	0.3
Diff in mean of infusions in LGA sessions	1.8	2.0	2.0	1.4	-1.4	-1.4
Extinction: sum of active levers before priming	0.4	0.4	0.4	0.6	-0.6	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	0.4	0.3
Delta distance traveled before/after self-admin	1.4	1.4	1.7	-1.1	1.2	1.3
Delta ambulatory time before/after self-admin	2.6	2.8	3.5	-1.6	1.6	1.9
Time in closed arm before self-admin	0.3	0.4	0.4	-0.7	0.7	0.6
Time in closed arm after self-admin	0.6	0.7	0.8	-0.9	0.9	0.7
Time in open arm before self-admin	0.9	1.0	1.5	1.2	-1.2	-0.3
Time in open arm after self-admin	0.4	0.4	0.6	0.5	-0.5	-0.8
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.9	-0.8	-0.1
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.6	-0.6	0.7	1.2
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.9	-1.0	1.1	2.0
Time to tail flick, test, before self-admin	0.6	0.6	0.9	-1.0	0.9	-0.1
Time to tail flick, test, after self-admin	2.0	2.0	2.2	-1.5	1.5	1.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.4	0.5	0.9
Delta time to tail flick, test, before/after SA	0.9	0.8	0.9	-0.9	0.9	0.9
Ambulatory time before self-admin	0.2	0.2	0.4	0.2	-0.3	-0.7
Ambulatory time after self-admin	0.4	0.5	0.6	-0.8	0.8	0.6
Total heroin consumption	0.6	0.7	0.7	0.9	-0.9	-0.8
Area under the delay curve	0.9	0.9	2.2	0.5	-0.6	-1.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.6	0.6	0.5
Delay disc. indifference point, 16s delay	1.3	1.3	3.1	0.6	-0.7	-1.8
Delay disc. indifference point, 2s delay	1.6	1.7	2.2	1.5	-1.5	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	0.1	-0.4
Delay disc. indifference point, 4s delay	1.0	1.1	2.6	0.6	-0.6	-1.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.4	0.4	-0.5
Delay discount exponential model param	0.8	0.8	1.8	-0.5	0.6	1.3
Delay discount hyperbolic model param	1.0	1.0	2.1	-0.6	0.7	1.5
Fecal boli incidents, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	-0.4
Change in fecal boli incidents, locomotor task	1.7	1.6	2.8	-0.9	1.0	1.7
Time >=10cm from walls, locomotor time 1	1.5	1.5	3.7	-0.6	0.7	1.9
Bouts of movement, locomotor time 1	2.3	2.6	3.9	-2.0	1.9	0.5
Total resting periods, locomotor time 1	1.8	2.0	2.9	-1.7	1.6	0.6
Rest time, locomotor task time 1	1.5	1.6	2.0	-1.4	1.4	0.9
Distance moved, locomotor task time 1	0.3	0.3	0.4	0.5	-0.5	-0.6
Vertical activity count, locomotor time 1	1.2	1.2	1.6	1.3	-1.2	-0.6
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.8	-0.0	0.1	1.3
Bouts of movement, locomotor time 2	0.7	0.8	1.1	-1.0	0.9	-0.6
Total resting periods, locomotor time 2	0.7	0.8	1.0	-1.0	0.9	-0.6
Rest time, locomotor task time 2	0.0	0.1	0.1	-0.2	0.1	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	0.2	0.0
Vertical activity count, locomotor time 2	1.7	1.9	2.1	1.4	-1.4	-1.2
Weight adjusted by age	0.9	1.0	1.3	1.2	-1.1	-0.5
Seeking ratio, delayed vs. immediate footshock	6.9	7.8	10.6	-2.5	2.6	3.3
Locomotion in novel chamber	1.0	1.2	1.6	1.2	-1.2	-0.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	0.1	-0.3
Progressive ratio	1.6	1.9	2.5	-1.6	1.6	0.9
Food seeking constrained by brief footshock	3.5	4.3	4.9	2.2	-2.2	-1.7
Seeking ratio, punishment vs. effort	4.9	6.0	7.1	2.7	-2.7	-2.0
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.3	-0.2
Run reversals in cocaine runway, males	3.3	3.2	3.4	1.8	-1.8	-1.7
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.4	0.4	0.8
Latency to leave start box in cocaine runway, F	1.8	2.0	3.5	-1.1	1.1	1.9
Latency to leave start box in cocaine runway, M	2.2	2.1	2.7	1.3	-1.4	-1.6
Cd content in liver	0.2	0.2	0.4	-0.4	0.3	-0.6
Co content in liver	0.2	0.3	0.7	-0.3	0.3	-0.8
Cu content in liver	4.7	5.7	7.0	-2.2	2.3	2.6
Fe content in liver	0.7	0.9	1.3	1.1	-1.0	0.4
K content in liver	0.8	0.8	1.1	-1.0	1.0	0.5
Mg content in liver	0.1	0.1	0.2	-0.4	0.4	0.4
Mn content in liver	0.5	0.6	1.1	0.6	-0.6	-1.0
Na content in liver	1.4	1.5	1.6	-1.2	1.3	1.2
Rb content in liver	0.1	0.1	0.1	-0.4	0.3	-0.2
Se content in liver	0.2	0.3	0.4	-0.6	0.6	0.4
Sr content in liver	0.9	0.8	1.0	0.9	-0.9	-1.0
Zn content in liver	2.0	2.2	2.3	-1.5	1.5	1.4