Hub : Traits

Weight adjusted by age

Project: u01_tom_jhou

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 90636696 92031287 1 1 6.1e-14 0.036 6e-04 -168 Snx16

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
body_g 5.0 1 0 0 0 1 Snx16
dissection: PC 3 of all traits 18.0 1 1 100 0 1 Snx16
dissection: PC 2 of all traits 3.9 1 0 0 0 1 Snx16
heart_g 3.1 1 0 0 0 1 Snx16
os_mean 3.8 1 0 0 0 1 Snx16
EDL weight in grams 8.3 1 1 100 0 1 Snx16
TA weight in grams 8.2 1 1 100 0 1 Snx16
Average time between licks in bursts 3.0 1 0 0 0 1 Snx16
Delay discounting water rate 0 sec 3.6 1 0 0 0 1 Snx16
locomotor_testing_activity 2.5 1 0 0 0 1 Snx16
reaction_time_corr 5.6 1 0 0 0 1 Snx16
reaction_time_leftcorr 5.6 1 0 0 0 1 Snx16
delay_discounting_pc1800 4.8 1 0 0 0 1 Snx16
reaction_time_falsealarm 7.7 1 0 0 0 1 Snx16
reaction_time_peropfalsealarm_slope 3.2 1 0 0 0 1 Snx16
length 3.2 1 0 0 0 1 Snx16
tautz: manual_spc7 4.0 1 0 0 0 1 Snx16
tautz: manual_mpc15 5.0 1 0 0 0 1 Snx16
tautz: manual_mpc16 5.6 1 0 0 0 1 Snx16
tautz: manual_mpc4 14.1 1 0 0 0 1 Snx16
tautz: manual_mpc10 5.8 1 0 0 0 1 Snx16
tautz: manual_mpc5 9.2 1 0 0 0 1 Snx16
tautz: manual_spc22 3.0 1 0 0 0 1 Snx16
tautz: manual_mpc14 28.2 1 1 100 0 1 Snx16
tautz: manual_spc24 10.1 1 0 0 0 1 Snx16
tautz: manual_spc4 13.8 1 0 0 0 1 Snx16
tautz: manual_spc2 4.7 1 0 0 0 1 Snx16
tautz: manual_spc13 2.7 1 0 0 0 1 Snx16
tautz: manual_mpc19 3.5 1 0 0 0 1 Snx16
tautz: manual_spc10 3.6 1 0 0 0 1 Snx16
tautz: manual_spc6 4.2 1 0 0 0 1 Snx16
tautz: manual_spc20 14.7 1 0 0 0 1 Snx16
tautz: manual_mpc17 7.1 1 0 0 0 1 Snx16
tautz: manual_mpc2 3.5 1 0 0 0 1 Snx16
tautz: manual_spc16 4.5 1 0 0 0 1 Snx16
tautz: manual_spc5 6.7 1 0 0 0 1 Snx16
tautz: manual_spc3 18.0 1 0 0 0 1 Snx16
tautz: manual_mpc6 15.8 1 0 0 0 1 Snx16
tautz: manual_mpc11 14.4 1 0 0 0 1 Snx16
The total number of resting periods in time1 4.7 1 0 0 0 1 Snx16
punishment 16.8 1 0 0 0 1 Snx16
locomotor2 3.5 1 0 0 0 1 Snx16
Liver sodium concentration 3.7 1 0 0 0 1 Snx16

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.19
Adipose alternative TSS 0 0.000 1.13
Adipose gene expression 1 0.012 1.09
Adipose isoform ratio 0 0.000 1.15
Adipose intron excision ratio 0 0.000 1.11
Adipose mRNA stability 0 0.000 1.11
BLA alternative polyA 0 0.000 1.25
BLA alternative TSS 0 0.000 1.13
BLA gene expression 0 0.000 1.09
BLA isoform ratio 0 0.000 1.12
BLA intron excision ratio 0 0.000 1.26
BLA mRNA stability 0 0.000 1.14
Brain alternative polyA 0 0.000 1.15
Brain alternative TSS 0 0.000 1.09
Brain gene expression 0 0.000 1.08
Brain isoform ratio 0 0.000 1.05
Brain intron excision ratio 0 0.000 1.12
Brain mRNA stability 0 0.000 1.10
Eye alternative polyA 0 0.000 1.15
Eye alternative TSS 0 0.000 1.10
Eye gene expression 0 0.000 1.05
Eye isoform ratio 0 0.000 1.13
Eye intron excision ratio 0 0.000 1.11
Eye mRNA stability 0 0.000 1.15
IL alternative polyA 0 0.000 1.25
IL alternative TSS 0 0.000 0.94
IL gene expression 0 0.000 1.14
IL isoform ratio 0 0.000 1.21
IL intron excision ratio 0 0.000 1.27
IL mRNA stability 0 0.000 1.17
LHb alternative polyA 0 0.000 1.24
LHb alternative TSS 0 0.000 1.08
LHb gene expression 0 0.000 1.12
LHb isoform ratio 0 0.000 1.21
LHb intron excision ratio 0 0.000 1.33
LHb mRNA stability 0 0.000 1.08
Liver alternative polyA 0 0.000 1.08
Liver alternative TSS 0 0.000 1.03
Liver gene expression 0 0.000 1.04
Liver isoform ratio 0 0.000 1.08
Liver intron excision ratio 0 0.000 1.05
Liver mRNA stability 0 0.000 1.09
NAcc alternative polyA 0 0.000 1.14
NAcc alternative TSS 0 0.000 1.13
NAcc gene expression 0 0.000 1.09
NAcc isoform ratio 0 0.000 1.06
NAcc intron excision ratio 0 0.000 1.27
NAcc mRNA stability 0 0.000 1.14
NAcc2 alternative polyA 0 0.000 1.26
NAcc2 alternative TSS 0 0.000 1.19
NAcc2 gene expression 0 0.000 1.12
NAcc2 isoform ratio 0 0.000 1.12
NAcc2 intron excision ratio 0 0.000 1.17
NAcc2 mRNA stability 0 0.000 1.15
OFC alternative polyA 0 0.000 1.25
OFC alternative TSS 0 0.000 1.37
OFC gene expression 0 0.000 1.14
OFC isoform ratio 0 0.000 1.12
OFC intron excision ratio 0 0.000 1.32
OFC mRNA stability 0 0.000 1.13
PL alternative polyA 0 0.000 1.23
PL alternative TSS 0 0.000 1.22
PL gene expression 0 0.000 1.15
PL isoform ratio 0 0.000 1.09
PL intron excision ratio 0 0.000 1.18
PL mRNA stability 0 0.000 1.19
PL2 alternative polyA 0 0.000 1.27
PL2 alternative TSS 0 0.000 1.20
PL2 gene expression 0 0.000 1.12
PL2 isoform ratio 0 0.000 1.17
PL2 intron excision ratio 0 0.000 1.17
PL2 mRNA stability 0 0.000 1.13

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.