Hub : Traits : Extensor digitorum longus weight : ← →

chr10:87,148,755-89,011,911

Trait: Extensor digitorum longus weight

Best TWAS P=8.887881e-08 · Best GWAS P=1.742587e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Acbd4	alternative polyA	ENSRNOT00000004163	0.57	0.48	enet	153	0.52	1.4e-67	5.2	5.2	1.8e-07	0.93	0.21	0.79	FALSE
2	Adipose	Acbd4	alternative polyA	ENSRNOT00000118852	0.59	0.47	enet	213	0.51	1.3e-65	5.2	-5.2	2.2e-07	-0.91	0.21	0.79	TRUE
3	Adipose	Acbd4	gene expression	ENSRNOG00000003108	0.77	0.53	enet	252	0.66	4.8e-97	5.2	5.3	8.9e-08	0.89	0.21	0.79	TRUE
4	Adipose	Acbd4	isoform ratio	ENSRNOT00000004163	0.56	0.46	enet	256	0.48	6.7e-61	5.2	5.3	1.3e-07	0.94	0.21	0.79	FALSE
5	Adipose	Acbd4	isoform ratio	ENSRNOT00000118852	0.57	0.47	enet	241	0.50	2.0e-64	5.2	-5.2	1.6e-07	-0.95	0.21	0.79	FALSE
6	Adipose	Fmnl1	mRNA stability	ENSRNOG00000003207	0.10	0.09	top1	1	0.09	3.2e-10	5.1	-5.1	2.7e-07	-0.90	0.23	0.77	FALSE
7	BLA	Acbd4	alternative polyA	ENSRNOT00000118852	0.32	0.25	enet	229	0.27	7.6e-15	3.3	-5.2	2.4e-07	-0.92	1.00	0.00	FALSE
8	Brain	Acbd4	alternative polyA	ENSRNOT00000004163	0.23	0.26	top1	1	0.26	3.6e-24	5.1	5.1	3.4e-07	0.95	0.27	0.73	FALSE
9	Brain	Acbd4	alternative polyA	ENSRNOT00000118852	0.23	0.27	top1	1	0.27	1.9e-25	5.1	-5.1	3.4e-07	-0.95	0.27	0.73	FALSE
10	Brain	Arhgap27	alternative TSS	ENSRNOT00000038836	0.13	0.07	top1	1	0.07	3.1e-07	5.1	5.1	2.7e-07	0.97	0.24	0.74	TRUE
11	Brain	Arhgap27	alternative TSS	ENSRNOT00000119071	0.12	0.07	top1	1	0.07	5.0e-07	5.2	-5.2	2.3e-07	-0.97	0.22	0.76	FALSE
12	IL	Eftud2	gene expression	ENSRNOG00000002818	0.38	0.32	top1	1	0.32	1.8e-08	5.1	5.1	3.4e-07	0.97	0.20	0.48	FALSE
13	IL	Gfap	gene expression	ENSRNOG00000002919	0.18	0.09	lasso	2	0.12	6.8e-04	3.4	-5.1	3.5e-07	0.07	0.31	0.45	TRUE
14	IL	Acbd4	intron excision ratio	chr10:88052617:88053211	0.24	0.15	lasso	3	0.15	2.0e-04	5.1	-5.1	3.4e-07	-0.80	0.41	0.38	TRUE
15	LHb	Acbd4	alternative polyA	ENSRNOT00000004163	0.37	0.41	top1	1	0.41	8.4e-11	5.1	5.1	3.4e-07	0.96	0.25	0.67	FALSE
16	LHb	Acbd4	alternative polyA	ENSRNOT00000118852	0.38	0.39	lasso	2	0.40	1.3e-10	5.1	-5.1	3.4e-07	-1.00	0.24	0.76	FALSE
17	LHb	Acbd4	isoform ratio	ENSRNOT00000004163	0.39	0.28	top1	1	0.28	3.0e-07	5.1	5.1	3.4e-07	0.95	0.20	0.43	FALSE
18	LHb	Acbd4	isoform ratio	ENSRNOT00000118852	0.35	0.26	top1	1	0.26	6.5e-07	5.1	-5.1	3.4e-07	-0.95	0.18	0.36	FALSE
19	Liver	Acbd4	mRNA stability	ENSRNOG00000003108	0.10	0.05	blup	2232	0.07	1.1e-08	5.1	5.2	2.4e-07	0.88	0.33	0.67	FALSE
20	Liver	Dcakd	mRNA stability	ENSRNOG00000021682	0.03	0.02	top1	1	0.02	1.4e-03	5.1	5.1	2.7e-07	0.87	0.07	0.06	FALSE
21	NAcc	Gfap	gene expression	ENSRNOG00000002919	0.08	0.08	top1	1	0.08	1.5e-06	5.1	-5.1	2.7e-07	-0.97	0.20	0.67	FALSE
22	NAcc	Acbd4	intron excision ratio	chr10:88050047:88050475	0.16	0.17	top1	1	0.17	9.2e-13	5.2	-5.2	2.4e-07	-0.94	0.21	0.79	FALSE
23	OFC	Gfap	gene expression	ENSRNOG00000002919	0.28	0.14	lasso	4	0.19	2.7e-05	5.2	-5.2	2.2e-07	-0.55	0.30	0.68	FALSE
24	OFC	Acbd4	intron excision ratio	chr10:88050047:88050282	0.27	0.14	top1	1	0.14	3.5e-04	5.1	5.1	2.7e-07	0.90	0.12	0.08	FALSE
25	PL	Gfap	gene expression	ENSRNOG00000002919	0.16	0.10	blup	2103	0.12	2.5e-09	5.1	-5.2	2.6e-07	-0.95	0.22	0.78	FALSE
26	PL	Acbd4	gene expression	ENSRNOG00000003108	0.17	0.16	top1	1	0.16	2.1e-12	5.1	-5.1	2.7e-07	-0.91	0.23	0.77	FALSE
27	PL	Acbd4	intron excision ratio	chr10:88050047:88050475	0.15	0.12	top1	1	0.12	1.3e-09	5.2	-5.2	2.4e-07	-0.98	0.21	0.79	FALSE
28	PL	Dcakd	mRNA stability	ENSRNOG00000021682	0.09	0.07	top1	1	0.07	6.1e-06	5.2	5.2	2.5e-07	0.93	0.17	0.57	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.