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chr12:27,006-4,653,252

Best TWAS P=1.007955e-08 · Best GWAS P=7.062254e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Pet100	alternative TSS	ENSRNOT00000071928	0.22	0.10	enet	116	0.13	3.4e-14	-5.0	5.1	3.2e-07	-0.79	0.32	0.68	FALSE
2	Adipose	Pet100	alternative TSS	ENSRNOT00000107172	0.22	0.10	enet	122	0.13	2.6e-14	-4.6	-5.1	2.9e-07	0.80	0.34	0.66	FALSE
3	Adipose	Insr	gene expression	ENSRNOG00000029986	0.13	0.02	top1	1	0.02	4.3e-03	-5.1	5.1	2.8e-07	-0.81	0.05	0.06	TRUE
4	Adipose	Pet100	isoform ratio	ENSRNOT00000071928	0.23	0.11	enet	64	0.13	1.8e-14	-5.0	5.2	2.5e-07	-0.78	0.26	0.73	FALSE
5	Adipose	Pet100	isoform ratio	ENSRNOT00000107172	0.23	0.09	enet	66	0.13	2.6e-14	-5.0	-5.2	2.4e-07	0.78	0.26	0.74	FALSE
6	Adipose	Zfp958	isoform ratio	ENSRNOT00000102786	0.03	0.00	enet	169	0.01	6.9e-03	-4.6	5.3	9.8e-08	-0.94	0.28	0.35	FALSE
7	Adipose	Zfp958	intron excision ratio	chr12:3971128:3971331	0.03	0.00	blup	1113	0.01	2.8e-02	-4.4	5.3	1.0e-07	-0.84	0.21	0.24	TRUE
8	Adipose	Elavl1	mRNA stability	ENSRNOG00000001069	0.16	0.06	blup	2406	0.07	9.4e-09	-4.7	5.6	2.8e-08	-0.84	0.57	0.43	FALSE
9	BLA	Pet100	intron excision ratio	chr12:1680794:1680963	0.36	0.12	lasso	13	0.19	1.7e-10	-4.9	-5.2	2.5e-07	0.81	0.25	0.75	FALSE
10	BLA	Cers4	mRNA stability	ENSRNOG00000001072	0.16	0.06	blup	2109	0.08	5.0e-05	-4.7	5.4	6.3e-08	-0.79	0.58	0.39	FALSE
11	Brain	Elavl1	gene expression	ENSRNOG00000001069	0.07	0.01	blup	2406	0.02	4.4e-03	-4.8	-5.6	2.7e-08	0.88	0.46	0.41	FALSE
12	Brain	Arhgef18	gene expression	ENSRNOG00000028090	0.12	0.06	enet	11	0.08	1.2e-07	-4.8	-5.5	3.3e-08	0.92	0.23	0.77	FALSE
13	Brain	Trappc5	intron excision ratio	chr12:1737769:1740114	0.05	0.02	enet	18	0.03	5.1e-04	-4.4	-5.7	1.0e-08	0.76	0.42	0.45	TRUE
14	Eye	Elavl1	intron excision ratio	chr12:2667464:2684652	0.69	0.25	lasso	30	0.31	1.3e-05	-4.5	5.4	8.4e-08	-0.85	0.41	0.31	FALSE
15	IL	Snapc2	gene expression	ENSRNOG00000001056	0.35	0.00	lasso	5	0.03	8.2e-02	-5.0	-5.6	1.8e-08	0.58	0.25	0.34	FALSE
16	Liver	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.10	0.04	blup	681	0.07	2.3e-08	-5.0	5.1	3.1e-07	-0.97	0.18	0.82	FALSE
17	Liver	N4bp2l2	alternative polyA	ENSRNOT00000118063	0.10	0.04	blup	681	0.07	1.5e-08	-5.0	-5.1	2.8e-07	0.97	0.18	0.82	TRUE
18	Liver	Timm44	gene expression	ENSRNOG00000001058	0.11	0.03	enet	10	0.04	7.4e-05	-4.7	5.5	4.9e-08	-0.62	0.36	0.62	FALSE
19	Liver	Pet100	intron excision ratio	chr12:1680794:1680963	0.21	0.04	blup	1823	0.09	1.9e-10	-4.5	-5.3	1.0e-07	0.87	0.44	0.56	FALSE
20	Liver	Pet100	intron excision ratio	chr12:1680995:1681508	0.18	0.05	enet	152	0.07	3.1e-08	-4.8	5.2	2.5e-07	-0.49	0.30	0.70	FALSE
21	Liver	Zfp958	intron excision ratio	chr12:3953566:3958666	0.03	0.00	blup	1113	0.01	1.1e-02	-4.2	-5.5	4.5e-08	0.77	0.23	0.33	FALSE
22	NAcc2	Cers4	gene expression	ENSRNOG00000001072	0.33	0.31	enet	105	0.34	2.6e-19	-4.8	5.4	7.7e-08	-0.42	0.44	0.56	TRUE
23	NAcc2	Arhgef18	gene expression	ENSRNOG00000028090	0.14	0.05	blup	1531	0.09	2.0e-05	-4.9	-5.3	1.5e-07	0.91	0.32	0.67	FALSE
24	NAcc2	Zfp958	gene expression	ENSRNOG00000065430	0.14	0.08	blup	1115	0.14	5.4e-08	-4.6	-5.3	9.2e-08	0.85	0.46	0.53	FALSE
25	OFC	Snapc2	gene expression	ENSRNOG00000001056	0.54	0.04	blup	2272	0.12	1.0e-03	-4.8	-5.4	5.9e-08	0.62	0.29	0.44	FALSE
26	PL2	Stxbp2	gene expression	ENSRNOG00000000994	0.27	0.05	blup	1821	0.12	5.2e-07	-4.6	-5.3	1.2e-07	0.65	0.45	0.54	FALSE
27	PL2	Pet100	intron excision ratio	chr12:1680794:1680963	0.44	0.19	blup	1824	0.25	1.5e-13	-4.8	-5.2	1.8e-07	0.87	0.20	0.80	FALSE
28	PL2	Pet100	intron excision ratio	chr12:1680995:1681508	0.44	0.20	lasso	9	0.24	2.5e-13	-4.8	5.2	1.9e-07	-0.01	0.20	0.80	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.