Hub : Traits

Intermittent access day 1 total infusions

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201063126 202422121 1 1 7.4e-08 0.00018 0.033 67 Rhod
2 5 74868378 76264539 1 1 5.0e-10 0.00578 0.025 34 RGD1566134
3 7 16845355 16970279 1 1 1.0e-14 NaN NA NA NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 171.8 1 1 33 0 1 NA
Body weight 6.3 2 1 33 0 1 NA RGD1566134
Epididymis fat weight 136.2 1 1 33 0 1 NA
Glucose 5.9 2 0 0 0 1 Rhod NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 62.7 1 1 33 0 1 NA
Right kidney weight 67.3 1 1 33 0 1 NA
Tail length 91.1 1 1 33 0 1 NA
Length with tail 3.6 2 0 0 0 1 Rhod NA
Length without tail 61.4 2 1 33 0 1 NA RGD1566134
Liver weight, left 23.6 1 1 33 0 1 NA
Liver weight, right 9.6 1 0 0 0 1 NA
Parametrial fat weight 15.3 2 1 33 0 1 Rhod NA
Retroperitoneal fat weight 3.3 2 0 0 0 1 Rhod NA
Intraocular pressure 29.4 1 1 33 0 1 NA
Extensor digitorum longus weight 20.7 2 1 33 0 1 Rhod NA
Soleus weight 21.9 1 1 33 0 1 NA
Tibialis anterior weight 51.7 2 1 33 0 1 Rhod NA
Tibia length 5.5 2 0 0 0 1 Rhod NA
Number of licking bursts 242.4 1 1 33 0 1 NA
Food consumed during 24 hour testing period 11.6 2 0 0 0 1 NA RGD1566134
Times rat made contact with spout 121.6 1 1 33 0 1 NA
Mean time between licks in bursts 90.5 1 1 33 0 1 NA
Mean num. licks in bursts 258.2 1 1 33 0 1 NA
Std. dev. time between licks in bursts 291.0 1 1 33 0 1 NA
Water consumed over 24 hours 7.4 2 0 0 0 1 NA RGD1566134
Indifference point 0 sec 21.3 1 1 33 0 1 NA
Indifference point AUC 36.7 2 1 33 0 1 Rhod NA
Indifference point function ln k 4.5 2 0 0 0 1 Rhod NA
Indifference point function log k 4.5 2 0 0 0 1 Rhod NA
Delay discounting total patch changes 0 sec 20.1 1 1 33 0 1 NA
Delay discounting total patch changes 12 sec 81.5 2 1 33 0 1 Rhod NA
Delay discounting total patch changes 18 sec 277.7 1 1 33 0 1 NA
Delay discounting total patch changes 24 sec 20.4 3 1 33 0 1 Rhod NA RGD1566134
Delay discounting total patch changes 6 sec 75.6 2 1 33 0 1 NA RGD1566134
Delay discounting time to switch 0 sec 4.3 1 0 0 0 1 RGD1566134
Delay discounting water rate 0 sec 11.8 1 0 0 0 1 NA
Delay discounting water rate 12 sec 44.2 1 1 33 0 1 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0 1 NA
Delay discounting water rate 24 sec 100.9 1 1 33 0 1 NA
Delay discounting water rate 6 sec 70.2 1 1 33 0 1 NA
Locomotor testing distance 14.0 1 0 0 0 1 NA
Locomotor testing rearing 23.9 1 1 33 0 1 NA
Light reinforcement 1 43.7 2 1 33 0 1 NA RGD1566134
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 90.1 1 1 33 0 1 NA
Reaction time num false alarms AUC 128.2 1 1 33 0 1 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 62.5 1 1 33 0 1 NA
Reaction time mean AUC 89.1 1 1 33 0 1 NA
Median of all reaction times 80.2 1 1 33 0 1 NA
Reaction time false alarm rate 104.2 1 1 33 0 1 NA
Reaction time premature initiation rate 47.3 1 1 33 0 1 NA
Reaction time premature initiations 49.8 1 1 33 0 1 NA
Std. dev. reaction times 27.0 1 1 33 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social responses 108.6 1 1 33 0 1 NA
Social time 7.8 1 0 0 0 1 NA
Conditioned locomotion 6.1 1 0 0 0 1 RGD1566134
Cocaine response after cond. corrected 135.7 1 1 33 0 1 NA
Cocaine response after cond. not corrected 176.6 1 1 33 0 1 NA
Cocaine response before conditioning 28.6 1 1 33 0 1 NA
Saline control response 34.0 2 1 33 0 1 NA RGD1566134
Condit. Reinf. active minus inactive responses 46.4 1 1 33 0 1 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 33 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 14.3 1 0 0 0 1 RGD1566134
Pavlov. Cond. lever latency 45.0 2 2 67 0 1 NA RGD1566134
Pavlov. Cond. magazine entry latency 93.7 2 1 33 0 1 NA RGD1566134
Pavlov. Cond. change in total contacts 116.5 2 1 33 0 1 NA RGD1566134
Pavlov. Cond. index score 62.2 2 2 67 0 1 NA RGD1566134
Pavlov. Cond. latency score 68.0 2 2 67 0 1 NA RGD1566134
Pavlov. Cond. lever contacts 24.2 2 2 67 0 1 NA RGD1566134
Pavlov. Cond. magazine entry number 131.5 2 1 33 0 1 NA RGD1566134
Pavlov. Cond. intertrial magazine entries 106.2 1 1 33 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 55.2 2 1 33 0 1 NA RGD1566134
Pavlov. Cond. response bias 35.8 2 2 67 0 1 NA RGD1566134
Conditioned reinforcement - actives 18.5 1 0 0 0 1 NA
Conditioned reinforcement - inactives 5.3 2 0 0 0 1 Rhod RGD1566134
Conditioned locomotion 9.9 1 0 0 0 1 NA
Intermittent access intake day 1-15 change 104.0 1 1 33 0 1 NA
Intermittent access intake escalation 141.1 1 1 33 0 1 NA
Intermittent access intake escalation 2 42.5 1 1 33 0 1 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 33 0 1 NA
Intermitt. access escalation Index 9.2 1 0 0 0 1 NA
Intermittent access day 15 total infusions 11.5 1 0 0 0 1 Rhod
Intermittent access terminal intake (last 3 days) 11.8 1 0 0 0 1 Rhod
Intermittent access total infusions 9.7 2 0 0 0 1 Rhod RGD1566134
Intermittent access day 1 locomotion 22.6 2 1 33 0 1 Rhod NA
Intermittent access day 15 total locomotion 8.7 1 0 0 0 1 Rhod
Intermittent access total locomotion 12.8 2 0 0 0 1 Rhod RGD1566134
Post-drug Anxiety 20.6 1 0 0 0 1 NA
Baseline Anxiety 17.3 1 0 0 0 1 RGD1566134
Lifetime Intake 18.7 2 1 33 0 1 Rhod RGD1566134
Progressive ratio test 1 active lever presses 10.6 2 0 0 0 1 NA RGD1566134
Progressive ratio test 1 breakpoint 10.0 2 0 0 0 1 NA RGD1566134
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0 1 NA
Progressive ratio test 2 active lever presses 11.3 3 0 0 0 1 Rhod NA RGD1566134
Progressive ratio test 2 breakpoint 27.4 3 1 33 0 1 Rhod NA RGD1566134
Progressive ratio test 2 inactive lever presses 15.0 1 0 0 0 1 Rhod
Total sessions with >9 infusions 15.1 1 0 0 0 1 RGD1566134
Short access day 1 total inactive lever presses 7.2 1 0 0 0 1 Rhod
Short access day 10 total inactive lever presses 12.2 1 0 0 0 1 NA
Short access day 1 total infusions 16.4 2 0 0 0 1 Rhod RGD1566134
Short access day 10 total infusions 19.3 3 1 33 0 1 Rhod NA RGD1566134
Short access total infusions 32.5 2 1 33 0 1 Rhod RGD1566134
Short access day 1 locomotion 13.9 2 0 0 0 1 NA RGD1566134
Short access day 10 total locomotion 5.3 2 0 0 0 1 Rhod RGD1566134
Short access total locomotion 5.7 1 0 0 0 1 Rhod
Compulsive drug intake 20.9 3 1 33 0 1 Rhod NA RGD1566134
One hour access (0.3 mA shock) 8.8 3 0 0 0 1 Rhod NA RGD1566134
One hour access (shock baseline) 8.0 1 0 0 0 1 Rhod
Context. condit. distance diff. score 123.5 2 1 33 0 1 NA RGD1566134
Locomotion velocity, session 1 190.8 1 1 33 0 1 NA
Locomotion distance, session 1 609.6 1 1 33 0 1 NA
Locomotion velocity, session 2 139.6 1 1 33 0 1 NA
Locomotion distance, session 2 1269.9 1 1 33 0 1 NA
Locomotion velocity, session 3 178.9 1 1 33 0 1 NA
Locomotion distance, session 3 117.5 1 1 33 0 1 NA
Stereotopy head waving bouts, day 3 7.7 2 0 0 0 1 NA RGD1566134
Stereotopy head waving duration, day 3 24.4 2 1 33 0 1 NA RGD1566134
Locomotion velocity, session 7 98.9 1 1 33 0 1 NA
Locomotion distance, session 7 31.8 1 1 33 0 1 NA
Stereotopy head waving bouts, day 7 47.4 2 2 67 0 1 NA RGD1566134
Stereotopy head waving duration, day 7 60.0 2 1 33 0 1 NA RGD1566134
Locomotion distance, session 8 171.7 1 1 33 0 1 NA
Degree of sensitization distance 198.5 1 1 33 0 1 NA
Degree of sensitization stereotypy 26.8 2 1 33 0 1 NA RGD1566134
Condit. Reinf. active minus inactive responses 8.5 2 0 0 0 1 NA RGD1566134
Condit. Reinf. active-inactive response ratio 107.3 1 1 33 0 1 NA
Condit. Reinf. active responses 16.6 2 0 0 0 1 NA RGD1566134
Condit. Reinf. inactive responses 12.8 2 0 0 0 1 NA RGD1566134
Incentive salience index mean 13.1 2 0 0 0 1 NA RGD1566134
Condit. Reinf. lever presses 20.5 2 1 33 0 1 NA RGD1566134
Time in familiar zone, hab. session 1 16.4 1 0 0 0 1 NA
Time in novel zone, hab. session 1 17.4 1 0 0 0 1 NA
Total zone transitions, hab. session 1 673.8 1 1 33 0 1 NA
Total locomotion distance, hab. session 1 279.4 1 1 33 0 1 NA
Locomotion velocity, hab. session 1 349.5 1 1 33 0 1 NA
Time in familiar zone, hab. session 2 48.9 1 1 33 0 1 NA
Time in novel zone, hab. session 2 58.4 1 1 33 0 1 NA
Total zone transitions, hab. session 2 421.2 1 1 33 0 1 NA
Total locomotion distance, hab. session 2 110.4 2 1 33 0 1 NA RGD1566134
Locomotion velocity, hab. session 2 116.3 2 1 33 0 1 NA RGD1566134
Total zone transitions, NPP test 376.1 1 1 33 0 1 NA
Total locomotion distance, NPP test 269.3 1 1 33 0 1 NA
Locomotion velocity, NPP test 317.8 1 1 33 0 1 NA
Pavlov. Cond. lever latency 7.4 2 0 0 0 1 NA RGD1566134
Pavlov. Cond. magazine entry latency 95.9 1 1 33 0 1 NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0 1 NA
Pavlov. Cond. index score 51.9 1 1 33 0 1 NA
Pavlov. Cond. latency score 16.6 1 0 0 0 1 NA
Pavlov. Cond. lever contacts 16.1 1 0 0 0 1 NA
Pavlov. Cond. magazine entry number 61.6 1 1 33 0 1 NA
Pavlov. Cond. intertrial magazine entries 6.5 1 0 0 0 1 RGD1566134
Pavlov. Cond. lever-magazine prob. diff. 88.1 1 1 33 0 1 NA
Pavlov. Cond. response bias 52.4 1 1 33 0 1 NA
Bone: apparent density 21.4 2 1 33 0 1 NA RGD1566134
Bone surface 27.9 2 1 33 0 1 NA RGD1566134
Bone volume 29.6 2 1 33 0 1 NA RGD1566134
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical apparent density 5.4 1 0 0 0 1 RGD1566134
Bone: cortical porosity 188.5 1 1 33 0 1 NA
Bone: cortical porosity 155.8 1 1 33 0 1 NA
Bone: cortical thickness 6.2 2 0 0 0 1 Rhod NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: cortical tissue density 5.2 1 0 0 0 1 RGD1566134
Bone: elastic displacement 28.2 1 1 33 0 1 NA
Bone: endosteal estimation 11.4 2 1 33 0 1 NA RGD1566134
Bone: endosteal perimeter 7.0 1 0 0 0 1 RGD1566134
Bone: final force 57.4 1 1 33 0 1 NA
Bone: final moment 45.6 1 1 33 0 1 NA
Bone: marrow area 9.7 2 1 33 0 1 NA RGD1566134
Bone: maximum diameter 7.2 1 0 0 0 1 RGD1566134
Bone: maximum force 60.3 1 1 33 0 1 NA
Bone: maximum moment 41.2 1 1 33 0 1 NA
Bone: minimum diameter 86.7 1 1 33 0 1 NA
Bone: periosteal estimation 10.0 1 0 0 0 1 NA
Bone: periosteal perimeter 8.8 1 0 0 0 1 NA
Bone: post-yield work 124.3 1 1 33 0 1 NA
Bone: stiffness 136.8 1 1 33 0 1 NA
Bone: tissue strength 136.0 1 1 33 0 1 NA
Bone: trabecular number 64.1 1 1 33 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 12.4 2 0 0 0 1 NA RGD1566134
Bone: trabecular tissue density 66.6 1 1 33 0 1 NA
Distance traveled before self-admin 12.6 1 0 0 0 1 NA
Delta time in closed arm before/after self-admin 6.3 1 0 0 0 1 RGD1566134
Delta time in open arm before/after self-admin 40.2 1 1 33 0 1 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0 1 NA
Active lever presses in extinction session 6 8.8 3 0 0 0 1 Rhod NA RGD1566134
Delta distance traveled before/after self-admin 11.3 1 0 0 0 1 NA
Time in closed arm before self-admin 78.0 1 1 33 0 1 NA
Time in closed arm after self-admin 40.2 1 1 33 0 1 NA
Time in open arm after self-admin 31.3 1 1 33 0 1 NA
Sum of active levers in priming session hrs 5-6 14.2 1 0 0 0 1 Rhod
Time to tail flick, test, before self-admin 8.2 1 0 0 0 1 Rhod
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0 1 NA
Delta time to tail flick, test, before/after SA 16.2 2 0 0 0 1 Rhod NA
Ambulatory time before self-admin 5.7 1 0 0 0 1 NA
Total heroin consumption 5.5 1 0 0 0 1 Rhod
Area under the delay curve 6.6 1 0 0 0 1 Rhod
Delay disc. indifference point, 0s delay 9.4 2 0 0 0 1 Rhod RGD1566134
Delay disc. indifference point, 4s delay 23.4 1 0 0 0 1 RGD1566134
Delay discount exponential model param 6.1 1 0 0 0 1 Rhod
Delay discount hyperbolic model param 5.9 1 0 0 0 1 Rhod
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 14.1 2 0 0 0 1 Rhod NA
Time >=10cm from walls, locomotor time 2 21.0 2 1 33 0 1 NA RGD1566134
Total resting periods, locomotor time 2 5.7 2 0 0 0 1 NA RGD1566134
Rest time, locomotor task time 2 8.8 1 0 0 0 1 NA
Distance moved, locomotor task time 2 9.1 2 0 0 0 1 NA RGD1566134
Weight adjusted by age 16.4 2 1 33 0 1 NA RGD1566134
Seeking ratio, delayed vs. immediate footshock 14.6 2 1 33 0 1 NA RGD1566134
Locomotion in novel chamber 9.0 2 0 0 0 1 Rhod NA
Run reversals in cocaine runway, females 11.1 1 0 0 0 1 RGD1566134
Run reversals in cocaine runway, males 39.3 1 1 33 0 1 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0 1 NA
Cd content in liver 239.3 1 1 33 0 1 NA
Co content in liver 143.3 1 1 33 0 1 NA
Fe content in liver 9.6 2 0 0 0 1 NA RGD1566134
K content in liver 87.3 1 1 33 0 1 NA
Mn content in liver 207.1 1 1 33 0 1 NA
Na content in liver 15.7 1 0 0 0 1 RGD1566134
Rb content in liver 14.1 3 1 33 0 1 Rhod NA RGD1566134
Se content in liver 47.0 1 1 33 0 1 NA
Zn content in liver 30.5 2 1 33 0 1 NA RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.07
Adipose alternative TSS 0 0.000 1.22
Adipose gene expression 0 0.000 1.13
Adipose isoform ratio 0 0.000 1.16
Adipose intron excision ratio 0 0.000 1.08
Adipose mRNA stability 0 0.000 1.15
BLA alternative polyA 0 0.000 1.09
BLA alternative TSS 0 0.000 1.13
BLA gene expression 0 0.000 1.12
BLA isoform ratio 0 0.000 1.13
BLA intron excision ratio 0 0.000 1.12
BLA mRNA stability 0 0.000 1.16
Brain alternative polyA 0 0.000 1.09
Brain alternative TSS 0 0.000 1.14
Brain gene expression 0 0.000 1.13
Brain isoform ratio 0 0.000 1.19
Brain intron excision ratio 0 0.000 1.14
Brain mRNA stability 0 0.000 1.17
Eye alternative polyA 0 0.000 1.22
Eye alternative TSS 0 0.000 1.10
Eye gene expression 0 0.000 1.21
Eye isoform ratio 0 0.000 1.11
Eye intron excision ratio 0 0.000 1.04
Eye mRNA stability 0 0.000 1.24
IL alternative polyA 0 0.000 1.08
IL alternative TSS 0 0.000 1.25
IL gene expression 0 0.000 1.14
IL isoform ratio 0 0.000 1.12
IL intron excision ratio 0 0.000 1.17
IL mRNA stability 0 0.000 1.23
LHb alternative polyA 0 0.000 1.16
LHb alternative TSS 0 0.000 1.11
LHb gene expression 0 0.000 1.20
LHb isoform ratio 0 0.000 1.21
LHb intron excision ratio 0 0.000 1.13
LHb mRNA stability 0 0.000 1.17
Liver alternative polyA 0 0.000 0.95
Liver alternative TSS 0 0.000 1.14
Liver gene expression 1 0.014 1.15
Liver isoform ratio 0 0.000 1.17
Liver intron excision ratio 1 0.023 1.16
Liver mRNA stability 0 0.000 1.18
NAcc alternative polyA 0 0.000 1.06
NAcc alternative TSS 0 0.000 1.21
NAcc gene expression 0 0.000 1.13
NAcc isoform ratio 0 0.000 1.11
NAcc intron excision ratio 0 0.000 1.09
NAcc mRNA stability 0 0.000 1.13
OFC alternative polyA 0 0.000 1.17
OFC alternative TSS 0 0.000 1.02
OFC gene expression 0 0.000 1.16
OFC isoform ratio 0 0.000 1.11
OFC intron excision ratio 0 0.000 1.09
OFC mRNA stability 0 0.000 1.16
PL alternative polyA 0 0.000 1.06
PL alternative TSS 0 0.000 1.08
PL gene expression 0 0.000 1.14
PL isoform ratio 1 0.045 1.14
PL intron excision ratio 0 0.000 1.10
PL mRNA stability 0 0.000 1.18

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.