Hub : Genes

Arl5c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	ENSRNOG00000036880	0.05	0.04	1.7e-03	0.02	0.02	0.02	0.01	8.1e-03	1.3e-02	2.1e-02	2.4e-02
2	PL	gene expression	ENSRNOG00000036880	0.05	0.04	1.2e-03	0.04	0.04	0.02	0.03	1.0e-03	7.1e-04	1.0e-02	1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.6	5.2	5.3	2.3	-2.3
BMI without tail	0.1	0.2	0.2	0.3	-0.5
Body weight	6.3	26.6	27.1	5.2	-5.1
Epididymis fat weight	0.4	0.9	1.2	1.1	-0.8
Glucose	0.7	1.0	1.0	-1.0	1.0
Heart weight	3.5	5.0	5.5	2.3	-2.1
Left kidney weight	2.4	6.8	7.1	2.6	-2.7
Right kidney weight	0.5	1.4	1.5	1.2	-1.2
Tail length	1.0	3.0	3.3	1.7	-1.8
Length with tail	5.0	18.3	18.4	4.3	-4.3
Length without tail	5.1	11.1	11.6	3.4	-3.3
Liver weight, left	0.1	0.1	0.2	0.4	-0.3
Liver weight, right	0.0	0.0	0.0	-0.1	0.2
Parametrial fat weight	0.4	0.8	1.1	-0.8	1.0
Retroperitoneal fat weight	0.1	0.4	0.6	0.8	-0.5
Intraocular pressure	1.2	1.7	1.8	1.3	-1.3
Extensor digitorum longus weight	8.1	32.6	33.4	5.6	-5.8
Soleus weight	0.5	1.6	1.7	-1.3	1.2
Tibialis anterior weight	1.2	4.1	4.6	1.9	-2.1
Tibia length	0.7	2.1	2.2	1.4	-1.5
Number of licking bursts	0.7	0.8	0.9	-0.9	0.8
Food consumed during 24 hour testing period	0.9	1.1	1.2	1.0	-1.1
Times rat made contact with spout	1.1	1.3	1.5	-1.2	1.0
Mean time between licks in bursts	1.4	2.0	2.0	1.4	-1.4
Mean num. licks in bursts	0.0	0.0	0.0	-0.0	0.0
Std. dev. time between licks in bursts	0.2	0.3	0.3	0.5	-0.6
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.0
Indifference point 0 sec	1.3	2.1	2.2	-1.5	1.5
Indifference point AUC	0.0	0.0	0.0	0.0	-0.2
Indifference point function ln k	0.0	0.0	0.0	-0.1	0.1
Indifference point function log k	0.0	0.0	0.0	-0.1	0.1
Delay discounting total patch changes 0 sec	0.9	1.4	1.4	-1.2	1.2
Delay discounting total patch changes 12 sec	4.4	5.8	6.0	-2.4	2.4
Delay discounting total patch changes 18 sec	0.5	0.6	0.7	-0.8	0.7
Delay discounting total patch changes 24 sec	2.3	2.9	3.2	-1.8	1.6
Delay discounting total patch changes 6 sec	1.5	2.3	2.5	-1.6	1.4
Delay discounting time to switch 0 sec	0.0	0.1	0.1	-0.2	0.3
Delay discounting water rate 0 sec	0.0	0.0	0.0	0.2	-0.2
Delay discounting water rate 12 sec	0.3	0.4	0.4	0.6	-0.7
Delay discounting water rate 18 sec	0.5	0.6	0.7	-0.7	0.8
Delay discounting water rate 24 sec	0.2	0.3	0.4	-0.4	0.6
Delay discounting water rate 6 sec	0.8	1.1	1.2	-1.0	1.1
Locomotor activity	0.7	1.1	1.1	-1.0	1.0
Locomotor testing distance	3.1	5.2	5.4	-2.2	2.3
Locomotor testing rearing	5.8	9.0	9.1	-3.0	3.0
Light reinforcement 1	1.7	3.2	3.5	-1.7	1.9
Light reinforcement 2	0.5	0.7	0.8	-0.8	0.9
Reaction time number correct	0.7	1.0	1.0	1.0	-1.0
Reaction time mean minus median	0.0	0.0	0.1	0.2	-0.2
Reaction time mean minus median AUC	0.3	0.4	0.4	-0.6	0.6
Reaction time num false alarms	0.8	1.1	1.1	-1.0	1.1
Reaction time num false alarms AUC	0.6	0.8	0.9	-0.9	0.9
Reaction time trials correct on left	0.7	1.0	1.0	1.0	-1.0
Reaction time trials on left	0.7	1.0	1.0	1.0	-1.0
Reaction time mean	0.0	0.0	0.1	-0.3	0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.2	0.0
Median of all reaction times	0.3	0.5	0.6	-0.8	0.6
Reaction time omissions	0.7	0.9	1.0	-1.0	0.9
Reaction time false alarm rate	1.2	1.7	1.8	-1.3	1.3
Reaction time premature initiation rate	0.2	0.3	0.4	-0.5	0.6
Reaction time premature initiations	0.0	0.1	0.1	0.3	-0.2
Std. dev. reaction times	0.0	0.0	0.0	-0.2	0.1
Reaction time trials completed	0.7	1.0	1.0	1.0	-1.0
Reaction time trials AUC	0.5	0.7	0.8	0.8	-0.9
Social response proportion	0.0	0.0	0.0	-0.1	0.1
Social responses	0.1	0.1	0.1	-0.3	0.3
Social time	0.0	0.0	0.0	0.1	-0.1
Conditioned locomotion	0.1	0.1	0.1	-0.2	0.4
Cocaine response after cond. corrected	2.6	2.9	3.2	-1.8	1.6
Cocaine response after cond. not corrected	4.2	4.7	5.1	-2.3	2.1
Cocaine response before conditioning	1.0	1.2	1.3	-1.1	1.1
Saline control response	0.3	0.4	0.5	-0.6	0.7
Condit. Reinf. active minus inactive responses	0.5	0.7	0.7	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. active responses	1.0	1.4	1.4	-1.1	1.2
Condit. Reinf. inactive responses	2.2	2.7	3.0	-1.6	1.7
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.2	0.2
Condit. Reinf. lever reinforcers received	0.9	1.3	1.3	-1.1	1.1
Pavlov. Cond. lever latency	0.2	0.3	0.3	0.5	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.0	-0.1
Pavlov. Cond. change in total contacts	0.4	0.6	0.6	-0.8	0.8
Pavlov. Cond. index score	0.2	0.3	0.3	-0.6	0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.4	0.3
Pavlov. Cond. lever contacts	0.8	1.1	1.1	-1.1	1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	-0.3
Pavlov. Cond. intertrial magazine entries	1.5	2.0	2.0	1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.4	0.3
Pavlov. Cond. response bias	1.0	1.3	1.4	-1.2	1.1
Conditioned reinforcement - actives	1.2	1.2	1.6	-0.9	1.3
Conditioned reinforcement - inactives	1.0	1.1	1.4	-0.9	1.2
Conditioned locomotion	1.1	1.4	1.6	-1.1	1.3
Intermittent access intake day 1-15 change	0.1	0.1	0.1	-0.3	0.4
Intermittent access intake escalation	0.0	0.0	0.0	-0.2	0.2
Intermittent access intake escalation 2	0.1	0.1	0.1	0.1	-0.3
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.7	-0.6	0.9
Intermitt. access day 15 inactive lever presses	3.1	3.5	3.8	-1.9	1.8
Intermitt. access escalation Index	0.8	0.7	0.7	0.8	-0.8
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.2	0.4
Intermittent access day 15 total infusions	0.2	0.2	0.3	-0.3	0.5
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.3	-0.5	0.6
Intermittent access total infusions	0.0	0.0	0.0	0.1	0.2
Intermittent access day 1 locomotion	0.3	0.3	0.4	-0.4	0.6
Intermittent access day 15 total locomotion	0.5	0.6	0.7	-0.7	0.8
Intermittent access total locomotion	0.6	0.7	0.8	-0.7	0.9
Intermittent access standard deviation	0.2	0.2	0.2	-0.5	0.4
Cocaine induced anxiety	2.2	2.5	2.6	1.5	-1.6
Post-drug Anxiety	0.0	0.0	0.0	0.1	-0.1
Baseline Anxiety	3.2	3.4	3.5	-1.8	1.9
Lifetime Intake	0.0	0.0	0.0	0.1	0.1
Incentive Sensitization - Responses	1.3	1.3	1.5	-1.2	1.1
Incentive Sensitization - Breakpoint	1.3	1.3	1.5	-1.2	1.1
Progressive ratio test 1 active lever presses	1.2	1.3	1.4	-1.1	1.2
Progressive ratio test 1 breakpoint	1.1	1.1	1.3	-1.0	1.2
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.0	-0.8	1.0
Progressive ratio test 2 active lever presses	1.2	1.3	1.3	-1.1	1.1
Progressive ratio test 2 breakpoint	1.1	1.2	1.2	-1.1	1.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.2	0.2
Total sessions with >9 infusions	0.6	0.7	0.9	-0.7	0.9
Short access day 1 total inactive lever presses	1.2	1.3	1.7	-1.0	1.3
Short access day 10 total inactive lever presses	0.8	0.8	1.0	1.0	-0.8
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	0.4
Short access day 10 total infusions	0.1	0.2	0.2	-0.3	0.5
Short access total infusions	0.0	0.0	0.0	0.2	0.0
Short access day 1 locomotion	2.4	2.5	2.5	-1.6	1.6
Short access day 10 total locomotion	1.7	1.9	2.2	-1.2	1.5
Short access total locomotion	0.3	0.3	0.4	-0.3	0.7
Compulsive drug intake	0.1	0.1	0.1	0.3	-0.2
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.0	0.2
One hour access (shock baseline)	0.1	0.1	0.2	-0.3	0.4
Number of responses in last shaping day	0.0	0.0	0.0	-0.1	-0.2
Context. condit. distance diff. score	0.4	0.5	0.5	0.7	-0.7
Locomotion velocity, session 1	0.8	0.9	1.0	0.9	-1.0
Locomotion distance, session 1	4.3	5.5	5.6	2.4	-2.3
Locomotion velocity, session 2	0.7	0.9	0.9	0.9	-0.9
Locomotion distance, session 2	1.1	1.6	1.7	1.2	-1.3
Locomotion velocity, session 3	0.2	0.2	0.3	0.5	-0.5
Locomotion distance, session 3	0.6	0.6	0.7	0.7	-0.8
Stereotopy head waving bouts, day 3	3.6	4.4	4.6	-2.0	2.1
Stereotopy head waving duration, day 3	0.5	0.6	0.7	-0.7	0.8
Locomotion velocity, session 7	0.8	0.8	0.9	0.9	-0.9
Locomotion distance, session 7	0.1	0.1	0.2	0.5	-0.3
Stereotopy head waving bouts, day 7	1.1	1.2	1.3	-1.1	1.0
Stereotopy head waving duration, day 7	0.3	0.3	0.4	-0.6	0.5
Locomotion velocity, session 8	7.4	8.8	9.0	3.0	-2.9
Locomotion distance, session 8	1.7	2.5	2.6	1.6	-1.6
Degree of sensitization distance	0.3	0.3	0.3	0.6	-0.4
Degree of sensitization stereotypy	1.8	2.0	2.1	-1.5	1.4
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.8	-0.8	0.9
Condit. Reinf. active responses	0.7	0.9	0.9	-1.0	0.9
Condit. Reinf. inactive responses	0.6	0.8	0.8	-0.9	0.8
Incentive salience index mean	1.3	1.6	1.6	-1.3	1.3
Condit. Reinf. lever presses	1.0	1.4	1.4	-1.2	1.2
Time in familiar zone, hab. session 1	0.6	0.5	0.6	-0.7	0.8
Time in novel zone, hab. session 1	0.7	0.7	0.7	-0.8	0.8
Total zone transitions, hab. session 1	2.4	3.3	3.5	1.8	-1.9
Total locomotion distance, hab. session 1	0.1	0.1	0.1	0.3	-0.2
Locomotion velocity, hab. session 1	0.7	1.1	1.2	1.1	-1.0
Time in familiar zone, hab. session 2	0.4	0.4	0.5	-0.6	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	0.2
Total zone transitions, hab. session 2	0.7	0.9	0.9	0.9	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.4	-0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.5	0.7	-0.6
Novel to familiar place preference ratio	1.3	1.4	1.5	1.1	-1.2
Novelty place preference	0.8	0.8	0.8	0.9	-0.9
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.4
Total zone transitions, NPP test	0.4	0.5	0.5	0.7	-0.7
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.0	0.0
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	-0.7
Pavlov. Cond. lever latency	3.0	3.8	3.9	1.9	-2.0
Pavlov. Cond. magazine entry latency	10.9	14.1	14.1	-3.8	3.7
Pavlov. Cond. change in total contacts	8.6	9.2	9.3	-3.1	3.0
Pavlov. Cond. index score	9.1	11.6	11.7	-3.4	3.4
Pavlov. Cond. latency score	7.2	9.2	9.3	-3.0	3.0
Pavlov. Cond. lever contacts	2.8	3.3	3.3	-1.8	1.8
Pavlov. Cond. magazine entry number	13.7	17.2	17.4	4.2	-4.1
Pavlov. Cond. intertrial magazine entries	1.5	1.9	2.0	1.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	10.3	12.9	13.0	-3.6	3.6
Pavlov. Cond. response bias	10.2	12.5	12.5	-3.5	3.5
Bone: apparent density	2.2	3.7	3.9	-2.0	1.9
Bone surface	0.0	0.0	0.0	0.1	-0.1
Bone volume	0.1	0.1	0.1	-0.4	0.3
Bone: connectivity density	2.9	4.5	4.6	-2.1	2.1
Bone: cortical apparent density	6.0	7.8	7.9	-2.8	2.8
Bone: cortical area	0.2	0.4	0.4	-0.6	0.6
Bone: cortical porosity	0.8	0.8	0.8	-0.9	0.9
Bone: cortical porosity	1.0	1.1	1.1	-1.0	1.1
Bone: cortical thickness	1.9	3.1	3.5	-1.9	1.6
Bone: cortical thickness	5.5	6.5	6.6	-2.6	2.5
Bone: cortical tissue density	6.0	7.8	7.9	-2.8	2.8
Bone: elastic displacement	0.0	0.0	0.0	-0.2	0.1
Bone: elastic work	0.0	0.0	0.0	0.0	-0.0
Bone: endosteal estimation	2.4	5.1	5.6	2.4	-2.2
Bone: endosteal perimeter	2.1	4.3	4.6	2.1	-2.0
Bone: final force	1.2	2.0	2.1	-1.3	1.5
Bone: final moment	1.0	1.6	1.7	-1.2	1.3
Bone: marrow area	2.2	4.8	5.2	2.3	-2.1
Bone: maximum diameter	0.0	0.0	0.0	-0.2	0.1
Bone: maximum force	0.0	0.1	0.1	-0.2	0.3
Bone: maximum moment	0.0	0.0	0.0	-0.1	0.2
Bone: minimum diameter	0.5	0.9	1.0	1.0	-0.9
Bone: periosteal estimation	0.2	0.4	0.5	0.7	-0.6
Bone: periosteal perimeter	0.7	1.1	1.1	1.1	-1.0
Bone: post-yield work	1.0	1.4	1.5	1.2	-1.1
Bone: stiffness	0.0	0.1	0.1	-0.2	0.3
Bone: tissue strength	0.3	0.3	0.4	0.5	-0.6
Bone: trabecular number	5.2	8.2	8.2	-2.9	2.8
Bone: trabecular spacing	0.9	1.2	1.3	1.1	-1.0
Bone: trabecular thickness	0.0	0.0	0.1	-0.2	0.1
Bone: trabecular tissue density	0.0	0.0	0.0	-0.1	0.1
Breakpoint value in progressive ratio session	1.3	1.5	1.7	1.3	-1.1
Distance traveled before self-admin	0.2	0.2	0.3	0.5	-0.4
Distance traveled after self-admin	2.0	2.3	2.6	1.6	-1.4
Delta time in closed arm before/after self-admin	3.8	3.7	3.7	1.9	-1.9
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.2	0.2
Diff in mean of infusions in LGA sessions	0.5	0.5	0.8	0.9	-0.5
Extinction: sum of active levers before priming	0.8	0.8	0.9	1.0	-0.8
Active lever presses in extinction session 6	0.3	0.3	0.3	-0.5	0.5
Delta distance traveled before/after self-admin	1.2	1.3	1.3	1.1	-1.1
Delta ambulatory time before/after self-admin	0.4	0.4	0.4	0.7	-0.6
Time in closed arm before self-admin	1.1	1.2	1.3	-1.1	1.1
Time in closed arm after self-admin	0.6	0.6	0.7	0.7	-0.8
Time in open arm before self-admin	3.2	3.4	3.5	1.8	-1.9
Time in open arm after self-admin	0.6	0.7	0.8	0.9	-0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.4	-0.5	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.2	-0.5	0.3
Time to tail flick, test, before self-admin	0.8	0.8	0.9	0.9	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.4	-0.6	0.6
Delta time to tail flick, test, before/after SA	2.4	2.1	2.5	-1.6	1.3
Ambulatory time before self-admin	0.5	0.5	0.5	0.7	-0.6
Ambulatory time after self-admin	3.5	3.9	4.2	2.0	-1.9
Total heroin consumption	0.4	0.4	0.5	-0.7	0.6
Area under the delay curve	0.8	0.8	0.9	-0.8	1.0
Delay disc. indifference point, 0s delay	1.4	1.5	1.6	-1.3	1.2
Delay disc. indifference point, 16s delay	0.7	0.7	0.8	-0.8	0.9
Delay disc. indifference point, 2s delay	2.4	2.6	2.8	-1.6	1.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	0.3
Delay disc. indifference point, 4s delay	0.7	0.7	0.8	-0.9	0.8
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	-0.6	0.8
Delay discount exponential model param	0.4	0.4	0.5	0.6	-0.7
Delay discount hyperbolic model param	0.6	0.6	0.7	0.7	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.2	0.4	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.2	0.4
Time >=10cm from walls, locomotor time 1	0.8	0.8	0.9	-0.9	0.9
Bouts of movement, locomotor time 1	0.5	0.6	0.6	0.8	-0.7
Total resting periods, locomotor time 1	0.8	0.9	1.0	1.0	-0.9
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.0	-0.0
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.4	0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.2	-0.1
Time >=10cm from walls, locomotor time 2	2.4	2.5	2.6	-1.6	1.6
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.3	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	0.0
Rest time, locomotor task time 2	1.1	1.3	1.4	1.2	-1.1
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.2	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	-0.1
Weight adjusted by age	0.1	0.1	0.2	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	0.0
Locomotion in novel chamber	6.1	7.6	9.0	-3.0	2.5
Locomotion in novel chamber post-restriction	0.7	0.8	0.8	-0.9	0.9
Progressive ratio	0.0	0.0	0.0	0.0	0.0
Food seeking constrained by brief footshock	0.2	0.2	0.2	-0.4	0.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.3	-0.6	0.5
Run reversals in cocaine runway, females	2.4	2.4	2.4	1.6	-1.5
Run reversals in cocaine runway, males	0.8	0.7	0.8	-0.9	0.8
Latency to leave start box in cocaine runway	3.0	3.3	3.4	1.8	-1.8
Latency to leave start box in cocaine runway, F	2.6	2.9	2.9	1.7	-1.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.4	-0.5
Cd content in liver	0.1	0.1	0.1	-0.2	0.3
Co content in liver	1.5	1.7	1.7	1.3	-1.3
Cu content in liver	1.0	1.2	1.3	1.2	-1.1
Fe content in liver	1.5	1.8	1.8	1.3	-1.4
K content in liver	0.4	0.4	0.4	-0.7	0.5
Mg content in liver	0.4	0.4	0.5	-0.7	0.6
Mn content in liver	0.6	0.6	0.7	-0.8	0.8
Na content in liver	0.2	0.3	0.3	-0.5	0.5
Rb content in liver	1.1	1.3	1.4	-1.1	1.2
Se content in liver	2.5	3.1	3.2	-1.8	1.7
Sr content in liver	0.2	0.2	0.2	0.4	-0.4
Zn content in liver	1.6	1.8	2.0	-1.3	1.4