Hub : Genes

Scyl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000023668 0.05 0.03 2.1e-03 0.02 0.02 0.02 0.02 1.9e-03 3.0e-03 5.5e-03 9.4e-04
2 Adipose mRNA stability ENSRNOG00000023668 0.15 0.07 3.1e-11 0.1 0.09 0.09 0.1 2.8e-11 9.1e-10 1.4e-10 1.1e-10
3 BLA mRNA stability ENSRNOG00000023668 0.07 0.05 5.1e-04 0.04 0.06 0.06 0.05 5.8e-03 4.6e-04 6.1e-04 1.0e-03
4 IL mRNA stability ENSRNOG00000023668 0.26 0.14 3.3e-03 0.05 0.07 0.09 0.03 2.4e-02 1.0e-02 3.5e-03 6.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail4.915.929.31.7-5.44.43.4
BMI without tail2.04.16.31.0-2.52.51.7
Body weight2.39.820.9-1.3-4.14.60.4
Epididymis fat weight1.43.36.32.5-0.1-2.31.4
Glucose1.82.85.52.3-0.9-1.11.9
Heart weight1.62.34.21.90.7-2.10.9
Left kidney weight0.30.91.91.10.1-1.40.7
Right kidney weight0.10.20.8-0.1-0.1-0.9-0.1
Tail length1.13.56.5-2.41.10.6-2.6
Length with tail1.45.09.4-3.1-0.72.2-2.4
Length without tail1.43.04.3-2.0-1.62.1-1.2
Liver weight, left0.10.10.20.4-0.3-0.20.2
Liver weight, right0.10.20.30.6-0.6-0.3-0.4
Parametrial fat weight2.34.69.03.0-1.0-1.42.5
Retroperitoneal fat weight2.99.718.24.30.5-4.02.2
Intraocular pressure0.70.92.7-0.50.7-1.6-0.5
Extensor digitorum longus weight3.715.034.9-3.2-3.85.9-0.6
Soleus weight1.95.512.32.81.2-3.50.9
Tibialis anterior weight5.318.331.9-4.9-3.35.7-2.6
Tibia length0.72.03.1-1.7-1.81.2-0.7
Number of licking bursts0.10.20.4-0.4-0.30.60.1
Food consumed during 24 hour testing period0.50.51.1-1.00.5-0.3-0.9
Times rat made contact with spout0.30.40.8-0.60.50.9-0.1
Mean time between licks in bursts0.50.71.5-0.80.50.7-1.2
Mean num. licks in bursts0.20.20.70.20.8-0.3-0.0
Std. dev. time between licks in bursts0.40.51.1-0.20.9-0.4-1.0
Water consumed over 24 hours0.91.02.0-1.40.90.9-0.8
Indifference point 0 sec0.00.00.10.20.1-0.10.3
Indifference point AUC1.82.13.9-2.0-0.61.9-0.8
Indifference point function ln k4.36.111.43.01.8-3.40.8
Indifference point function log k4.36.111.43.01.8-3.40.8
Delay discounting total patch changes 0 sec0.10.10.2-0.10.5-0.2-0.3
Delay discounting total patch changes 12 sec2.22.97.2-1.8-1.02.7-0.3
Delay discounting total patch changes 18 sec0.30.41.0-0.3-0.71.00.3
Delay discounting total patch changes 24 sec1.41.83.2-1.8-0.31.5-1.3
Delay discounting total patch changes 6 sec0.40.61.8-0.6-0.41.3-0.2
Delay discounting time to switch 0 sec2.74.17.60.4-2.72.41.7
Delay discounting water rate 0 sec3.35.211.10.42.7-3.3-1.4
Delay discounting water rate 12 sec6.49.519.11.23.9-4.4-1.6
Delay discounting water rate 18 sec1.92.55.71.21.6-2.4-0.6
Delay discounting water rate 24 sec2.73.89.01.02.1-3.0-1.0
Delay discounting water rate 6 sec3.04.48.90.82.5-3.0-1.4
Locomotor activity1.72.64.70.12.1-2.2-1.2
Locomotor testing distance2.43.96.80.32.6-2.5-1.5
Locomotor testing rearing1.52.44.40.42.1-2.1-0.8
Light reinforcement 10.30.61.5-0.31.2-0.6-0.7
Light reinforcement 20.40.61.70.7-0.2-1.30.1
Reaction time number correct0.40.51.1-0.9-0.10.3-1.1
Reaction time mean minus median2.02.54.5-1.3-2.02.10.2
Reaction time mean minus median AUC1.01.31.8-1.3-1.21.3-0.4
Reaction time num false alarms0.30.51.20.21.1-0.6-0.5
Reaction time num false alarms AUC0.20.20.6-0.20.70.1-0.6
Reaction time trials correct on left0.40.51.1-0.9-0.10.3-1.1
Reaction time trials on left0.40.61.3-1.0-0.10.3-1.1
Reaction time mean0.10.10.2-0.4-0.40.20.4
Reaction time mean AUC0.10.20.4-0.2-0.50.20.6
Median of all reaction times0.10.10.30.0-0.2-0.10.6
Reaction time omissions0.71.02.0-1.1-0.81.4-0.1
Reaction time false alarm rate0.20.20.50.50.7-0.4-0.0
Reaction time premature initiation rate1.62.12.8-1.70.31.6-1.7
Reaction time premature initiations2.83.96.5-2.50.32.0-2.3
Std. dev. reaction times0.50.71.1-0.9-1.01.10.1
Reaction time trials completed0.40.61.3-1.0-0.10.3-1.1
Reaction time trials AUC0.30.41.0-0.8-0.00.2-1.0
Social response proportion0.50.61.0-0.8-0.81.0-0.1
Social responses0.30.40.8-0.90.10.3-0.9
Social time0.40.51.0-1.00.00.4-1.0
Conditioned locomotion0.91.01.7-1.1-0.81.3-0.7
Cocaine response after cond. corrected0.70.81.51.20.4-1.20.1
Cocaine response after cond. not corrected0.60.61.31.10.1-1.10.1
Cocaine response before conditioning0.30.40.7-0.7-0.60.80.1
Saline control response1.92.65.6-1.6-1.22.4-0.9
Condit. Reinf. active minus inactive responses0.20.20.50.4-0.5-0.30.7
Condit. Reinf. active-inactive response ratio1.21.21.61.2-1.3-0.71.2
Condit. Reinf. active responses0.20.20.50.1-0.40.50.7
Condit. Reinf. inactive responses0.30.31.0-0.30.41.00.2
Condit. Reinf. lever presses1.31.73.0-1.0-1.71.70.0
Condit. Reinf. lever reinforcers received0.20.30.5-0.3-0.40.70.5
Pavlov. Cond. lever latency0.50.71.80.31.4-0.8-0.2
Pavlov. Cond. magazine entry latency1.92.25.7-1.1-1.32.40.3
Pavlov. Cond. change in total contacts1.31.93.3-0.7-1.71.80.9
Pavlov. Cond. index score1.52.03.9-0.9-1.72.00.5
Pavlov. Cond. latency score1.41.73.2-0.6-1.81.80.5
Pavlov. Cond. lever contacts0.40.50.8-0.9-0.80.5-0.5
Pavlov. Cond. magazine entry number3.23.99.81.71.7-3.1-0.1
Pavlov. Cond. intertrial magazine entries0.50.71.90.90.3-1.40.2
Pavlov. Cond. lever-magazine prob. diff.1.72.24.8-1.0-1.72.20.4
Pavlov. Cond. response bias1.01.42.4-1.2-1.31.6-0.2
Conditioned reinforcement - actives0.20.20.6-0.1-0.1-0.8-0.2
Conditioned reinforcement - inactives3.03.38.91.11.6-3.00.7
Conditioned locomotion4.14.913.81.32.1-3.7-0.1
Intermittent access intake day 1-15 change0.80.81.8-0.40.8-1.3-0.6
Intermittent access intake escalation0.40.41.3-0.10.6-1.1-0.2
Intermittent access intake escalation 20.60.60.7-0.70.8-0.9-0.6
Intermitt. access day 1 inactive lever presses1.11.22.60.80.8-1.60.8
Intermitt. access day 15 inactive lever presses1.21.33.50.80.6-1.90.8
Intermitt. access escalation Index2.52.35.52.30.6-1.21.3
Intermittent access day 1 total infusions5.36.012.73.6-0.9-1.82.7
Intermittent access day 15 total infusions4.34.99.42.70.3-3.11.6
Intermittent access terminal intake (last 3 days)3.74.07.02.7-0.4-2.41.7
Intermittent access total infusions4.04.48.73.0-0.7-1.92.2
Intermittent access day 1 locomotion4.34.49.43.1-0.9-1.32.4
Intermittent access day 15 total locomotion2.62.85.21.90.3-2.31.5
Intermittent access total locomotion5.56.211.63.4-0.9-2.12.8
Intermittent access standard deviation0.60.72.20.10.6-1.5-0.2
Cocaine induced anxiety0.00.00.10.0-0.4-0.2-0.1
Post-drug Anxiety0.91.01.7-1.3-0.90.8-0.9
Baseline Anxiety1.51.63.3-1.8-0.41.4-1.0
Lifetime Intake3.74.28.62.9-0.8-1.72.2
Incentive Sensitization - Responses0.40.40.60.8-0.2-0.60.7
Incentive Sensitization - Breakpoint0.50.50.70.9-0.1-0.90.7
Progressive ratio test 1 active lever presses1.51.63.41.40.7-1.80.7
Progressive ratio test 1 breakpoint1.41.43.31.30.8-1.80.4
Progressive ratio test 1 inactive lever presses0.70.81.10.90.8-1.10.6
Progressive ratio test 2 active lever presses2.42.55.21.90.4-2.31.1
Progressive ratio test 2 breakpoint2.83.17.71.81.1-2.80.7
Progressive ratio test 2 inactive lever presses4.55.29.92.61.0-3.11.8
Total sessions with >9 infusions1.81.94.62.1-0.6-1.01.3
Short access day 1 total inactive lever presses1.92.13.61.70.8-1.91.2
Short access day 10 total inactive lever presses1.92.14.11.11.7-2.00.3
Short access day 1 total infusions3.43.68.12.8-0.6-1.12.2
Short access day 10 total infusions4.54.99.03.0-1.7-0.32.8
Short access total infusions2.52.86.02.5-1.1-0.61.9
Short access day 1 locomotion2.52.76.12.5-0.6-1.11.8
Short access day 10 total locomotion2.22.45.22.3-0.6-0.81.9
Short access total locomotion2.12.14.62.1-0.6-0.61.8
Compulsive drug intake2.22.23.4-1.80.81.5-1.6
One hour access (0.3 mA shock)5.15.914.12.71.2-3.81.0
One hour access (shock baseline)4.65.312.22.60.5-3.51.5
Number of responses in last shaping day0.90.91.80.31.3-1.4-0.4
Context. condit. distance diff. score0.91.12.01.30.5-1.40.6
Locomotion velocity, session 10.20.20.6-0.30.3-0.1-0.8
Locomotion distance, session 10.81.11.70.6-1.31.30.8
Locomotion velocity, session 21.61.94.9-0.5-1.52.20.3
Locomotion distance, session 20.70.92.20.4-1.01.50.7
Locomotion velocity, session 31.01.21.91.4-1.30.11.0
Locomotion distance, session 30.00.00.10.2-0.2-0.10.1
Stereotopy head waving bouts, day 31.21.53.31.8-1.2-0.30.9
Stereotopy head waving duration, day 30.70.81.91.4-0.6-0.60.7
Locomotion velocity, session 72.42.64.22.1-1.40.12.0
Locomotion distance, session 70.50.61.11.1-0.60.30.9
Stereotopy head waving bouts, day 70.50.61.10.8-0.7-0.11.0
Stereotopy head waving duration, day 70.91.11.9-0.0-1.21.41.0
Locomotion velocity, session 80.70.81.6-1.0-0.10.8-1.3
Locomotion distance, session 80.81.11.91.4-1.2-0.11.0
Degree of sensitization distance0.80.81.11.0-1.00.40.9
Degree of sensitization stereotypy0.50.50.8-0.1-0.90.80.7
Condit. Reinf. active minus inactive responses0.10.20.40.1-0.10.60.5
Condit. Reinf. active-inactive response ratio0.10.10.4-0.20.60.20.2
Condit. Reinf. active responses0.40.50.80.5-0.70.50.9
Condit. Reinf. inactive responses1.01.12.11.1-1.50.11.1
Incentive salience index mean0.60.71.00.5-0.91.01.0
Condit. Reinf. lever presses0.60.92.20.3-1.50.80.7
Time in familiar zone, hab. session 10.50.51.11.1-0.4-0.20.8
Time in novel zone, hab. session 10.80.81.2-0.61.1-0.7-1.1
Total zone transitions, hab. session 10.30.51.5-0.4-0.51.20.3
Total locomotion distance, hab. session 10.50.81.31.1-0.8-0.21.1
Locomotion velocity, hab. session 10.30.50.80.7-0.80.20.9
Time in familiar zone, hab. session 20.40.51.3-0.20.6-0.4-1.2
Time in novel zone, hab. session 20.40.41.10.1-0.30.61.0
Total zone transitions, hab. session 22.12.74.70.6-1.92.21.5
Total locomotion distance, hab. session 21.41.92.51.5-1.40.71.6
Locomotion velocity, hab. session 21.72.33.11.7-1.70.51.8
Novel to familiar place preference ratio0.80.81.4-0.6-1.11.20.7
Novelty place preference0.50.50.7-0.3-0.70.80.8
Time in novel zone, NPP test0.30.40.5-0.3-0.60.70.7
Total zone transitions, NPP test1.52.15.1-0.6-1.62.30.6
Total locomotion distance, NPP test0.60.81.10.7-1.00.71.0
Locomotion velocity, NPP test0.50.71.10.6-0.90.81.1
Pavlov. Cond. lever latency0.40.51.1-0.31.0-0.8-0.6
Pavlov. Cond. magazine entry latency0.81.11.90.6-1.01.01.4
Pavlov. Cond. change in total contacts0.60.61.60.4-0.70.51.3
Pavlov. Cond. index score0.10.20.3-0.0-0.50.50.5
Pavlov. Cond. latency score0.20.30.40.3-0.60.50.6
Pavlov. Cond. lever contacts0.10.20.20.4-0.50.30.5
Pavlov. Cond. magazine entry number0.10.20.30.60.1-0.5-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.1-0.01.1-1.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.1-0.70.80.6
Pavlov. Cond. response bias0.10.10.1-0.2-0.10.40.3
Bone: apparent density1.42.23.90.8-2.01.41.6
Bone surface3.15.511.3-0.8-3.43.00.9
Bone volume2.03.47.60.1-2.81.91.5
Bone: connectivity density2.03.25.7-0.1-2.42.41.1
Bone: cortical apparent density0.50.61.2-0.81.10.6-0.4
Bone: cortical area0.40.61.3-0.6-1.10.8-0.2
Bone: cortical porosity0.30.40.60.4-0.60.60.8
Bone: cortical porosity0.40.51.1-0.1-0.71.10.4
Bone: cortical thickness1.82.95.7-2.40.31.7-1.8
Bone: cortical thickness1.11.32.2-1.31.00.4-1.5
Bone: cortical tissue density0.60.71.3-1.01.20.6-0.5
Bone: elastic displacement2.02.23.9-0.32.0-1.6-1.5
Bone: elastic work0.91.12.2-1.30.60.6-1.5
Bone: endosteal estimation2.24.77.22.7-2.5-0.72.2
Bone: endosteal perimeter2.45.07.12.7-2.6-0.92.3
Bone: final force1.72.85.3-1.1-2.12.3-0.0
Bone: final moment1.52.54.6-1.0-2.02.2-0.0
Bone: marrow area2.34.87.72.8-2.5-0.72.3
Bone: maximum diameter0.40.83.0-0.1-1.70.20.1
Bone: maximum force3.05.311.4-0.4-3.42.91.1
Bone: maximum moment2.74.610.2-0.3-3.22.71.1
Bone: minimum diameter2.44.47.02.6-1.9-0.22.6
Bone: periosteal estimation1.12.25.71.2-2.40.11.2
Bone: periosteal perimeter0.71.23.60.5-1.90.40.8
Bone: post-yield work8.411.418.62.6-4.32.04.0
Bone: stiffness2.54.07.7-0.3-2.82.61.2
Bone: tissue strength0.10.10.20.1-0.40.20.3
Bone: trabecular number1.21.93.80.4-1.91.21.4
Bone: trabecular spacing0.40.51.50.11.2-0.5-0.5
Bone: trabecular thickness0.60.81.71.1-0.4-0.31.3
Bone: trabecular tissue density1.72.46.21.21.3-2.50.2
Breakpoint value in progressive ratio session1.51.73.6-1.5-1.01.9-0.2
Distance traveled before self-admin0.50.50.9-0.6-1.00.80.2
Distance traveled after self-admin0.10.20.4-0.7-0.00.40.0
Delta time in closed arm before/after self-admin0.20.20.5-0.20.30.1-0.7
Delta time in open arm before/after self-admin0.10.10.4-0.60.2-0.0-0.0
Diff in mean of infusions in LGA sessions0.40.51.2-1.10.10.4-0.7
Extinction: sum of active levers before priming2.62.66.8-1.0-1.52.60.6
Active lever presses in extinction session 61.61.53.0-1.7-0.81.0-1.2
Delta distance traveled before/after self-admin0.20.20.7-0.20.8-0.3-0.4
Delta ambulatory time before/after self-admin0.30.30.8-0.40.9-0.2-0.6
Time in closed arm before self-admin0.20.20.50.2-0.70.20.5
Time in closed arm after self-admin0.10.10.20.4-0.20.00.2
Time in open arm before self-admin0.50.51.50.51.2-0.5-0.3
Time in open arm after self-admin0.70.81.9-0.51.4-0.6-0.7
Sum of active levers in priming session hrs 5-61.61.64.3-2.1-0.40.4-1.4
Time to tail flick, vehicle, before self-admin0.80.82.00.3-1.40.90.6
Time to tail flick, vehicle, after self-admin1.11.22.60.2-1.41.60.4
Time to tail flick, test, before self-admin1.51.53.51.9-0.7-0.21.4
Time to tail flick, test, after self-admin0.10.10.2-0.30.2-0.1-0.5
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.1-0.40.90.1
Delta time to tail flick, test, before/after SA3.12.75.5-2.41.00.3-2.1
Ambulatory time before self-admin0.40.41.1-0.4-1.00.60.3
Ambulatory time after self-admin0.20.30.90.3-0.2-0.01.0
Total heroin consumption2.73.37.6-1.9-1.32.7-0.5
Area under the delay curve0.40.41.10.7-0.00.31.1
Delay disc. indifference point, 0s delay0.60.61.51.2-0.0-0.11.0
Delay disc. indifference point, 16s delay0.80.81.91.00.4-0.61.4
Delay disc. indifference point, 2s delay0.20.20.50.7-0.2-0.10.5
Delay disc. indifference point, 24s delay0.30.20.8-0.20.9-0.2-0.4
Delay disc. indifference point, 4s delay0.20.30.50.70.50.00.6
Delay disc. indifference point, 8s delay0.10.10.20.40.10.20.4
Delay discount exponential model param0.30.30.7-0.5-0.1-0.3-0.9
Delay discount hyperbolic model param0.20.20.6-0.5-0.1-0.3-0.8
Fecal boli incidents, locomotor time 10.40.41.2-0.2-1.10.00.5
Change in fecal boli incidents, locomotor task0.10.10.30.5-0.20.3-0.0
Time >=10cm from walls, locomotor time 12.92.94.11.9-1.9-0.32.0
Bouts of movement, locomotor time 11.11.23.0-1.70.41.2-0.4
Total resting periods, locomotor time 10.70.71.9-1.40.11.0-0.1
Rest time, locomotor task time 10.60.72.20.40.4-1.5-0.4
Distance moved, locomotor task time 10.60.60.80.8-0.80.70.9
Vertical activity count, locomotor time 10.70.71.50.80.8-1.20.4
Time >=10cm from walls, locomotor time 20.10.10.20.0-0.50.30.5
Bouts of movement, locomotor time 20.40.40.9-0.90.40.80.0
Total resting periods, locomotor time 20.20.20.5-0.60.30.70.2
Rest time, locomotor task time 21.11.32.61.40.3-1.60.6
Distance moved, locomotor task time 20.50.61.1-1.0-0.21.1-0.6
Vertical activity count, locomotor time 21.41.52.7-0.91.4-0.6-1.6
Weight adjusted by age1.21.42.1-1.4-1.01.4-0.6
Seeking ratio, delayed vs. immediate footshock0.40.41.10.6-0.10.31.1
Locomotion in novel chamber2.32.87.11.90.4-2.70.7
Locomotion in novel chamber post-restriction1.61.94.11.60.8-2.00.6
Progressive ratio3.74.28.10.5-2.82.41.7
Food seeking constrained by brief footshock0.20.20.3-0.50.40.3-0.6
Seeking ratio, punishment vs. effort3.13.98.5-0.22.9-2.1-1.6
Run reversals in cocaine runway, females1.51.51.81.1-1.21.41.2
Run reversals in cocaine runway, males1.51.52.2-0.71.3-1.2-1.5
Latency to leave start box in cocaine runway0.91.01.71.1-1.00.31.3
Latency to leave start box in cocaine runway, F0.40.41.10.6-0.30.41.0
Latency to leave start box in cocaine runway, M0.40.41.20.6-1.1-0.00.3
Cd content in liver0.80.92.70.10.9-1.6-0.3
Co content in liver3.13.69.3-0.63.1-1.7-1.4
Cu content in liver0.20.30.7-0.3-0.10.80.6
Fe content in liver0.10.20.5-0.2-0.70.2-0.4
K content in liver2.22.24.40.3-2.11.81.0
Mg content in liver2.12.23.71.3-1.51.11.9
Mn content in liver1.31.52.8-1.1-1.41.7-0.2
Na content in liver0.70.71.0-1.0-0.90.8-0.6
Rb content in liver1.11.32.61.60.3-0.81.4
Se content in liver0.30.40.90.3-0.90.00.7
Sr content in liver2.52.35.3-2.30.31.2-1.5
Zn content in liver0.60.72.0-0.6-0.51.40.3