| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | alternative polyA | ENSRNOT00000100410 | 0.0411 | 0.0289 | 6.2e-04 | 0.033 | 0.013 | 0.017 | 0.024 | 0.00012 | 1.2e-02 | 4.9e-03 | 0.00110 |
| 2 | Adipose | alternative TSS | ENSRNOT00000105874 | 0.0390 | 0.0247 | 2.9e-04 | 0.025 | 0.016 | 0.019 | 0.017 | 0.00073 | 6.0e-03 | 3.0e-03 | 0.00470 |
| 3 | Adipose | alternative TSS | ENSRNOT00000105874 | 0.0289 | 0.0195 | 2.5e-03 | 0.015 | 0.004 | 0.001 | 0.004 | 0.00720 | 1.2e-01 | 2.3e-01 | 0.10000 |
| 4 | Adipose | gene expression | ENSRNOG00000070897 | 0.0440 | 0.0270 | 1.6e-04 | 0.005 | 0.012 | 0.006 | 0.002 | 0.08700 | 1.3e-02 | 6.2e-02 | 0.16000 |
| 5 | Liver | alternative TSS | ENSRNOT00000105874 | 0.0401 | 0.0263 | 1.2e-03 | 0.005 | 0.017 | 0.017 | 0.012 | 0.08000 | 4.8e-03 | 4.5e-03 | 0.01300 |
| 6 | Liver | isoform ratio | ENSRNOT00000100410 | 0.1855 | 0.0882 | 1.4e-06 | 0.026 | 0.040 | 0.044 | 0.034 | 0.00062 | 2.7e-05 | 1.2e-05 | 0.00011 |
| 7 | Liver | isoform ratio | ENSRNOT00000100754 | 0.1331 | 0.0749 | 1.2e-05 | 0.016 | 0.024 | 0.011 | 0.016 | 0.00600 | 1.0e-03 | 2.0e-02 | 0.00580 |
| 8 | NAcc | alternative polyA | ENSRNOT00000100410 | 0.0361 | 0.0267 | 3.9e-03 | 0.015 | 0.025 | 0.009 | 0.015 | 0.02500 | 5.6e-03 | 7.0e-02 | 0.02300 |
| 9 | NAcc | gene expression | ENSRNOG00000070897 | 0.0480 | 0.0390 | 5.0e-03 | 0.023 | 0.015 | -0.003 | 0.012 | 0.00710 | 2.6e-02 | 5.9e-01 | 0.04200 |
| 10 | PL | isoform ratio | ENSRNOT00000099092 | 0.0460 | 0.0340 | 7.8e-03 | 0.029 | 0.014 | 0.010 | 0.024 | 0.00270 | 2.6e-02 | 5.8e-02 | 0.00570 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intermittent access total locomotion | 6.4 | 7.2 | 13.6 | -3.4 | -3.7 | -3.7 | 3.0 | 1.2 | 0.9 | 0.1 | -3.2 | -3.4 | 0.7 |
| Intermittent access day 1 total infusions | 6.3 | 7.2 | 13.8 | -3.3 | -3.5 | -3.5 | 3.1 | 1.4 | 0.3 | 0.6 | -3.1 | -3.7 | 1.1 |
| Bone: post-yield work | 6.0 | 8.1 | 15.7 | -2.9 | -2.9 | -2.9 | 3.7 | 4.0 | -1.0 | 3.0 | -0.6 | -2.1 | 3.5 |
| Tibialis anterior weight | 5.6 | 19.2 | 46.5 | 5.8 | 4.7 | 4.7 | -3.9 | 0.2 | -3.9 | 1.9 | 6.8 | 5.8 | 0.4 |
| Short access day 10 total infusions | 5.4 | 6.0 | 9.3 | -2.4 | -2.9 | -2.9 | 3.0 | 2.3 | -1.1 | 1.8 | -1.8 | -3.0 | 2.3 |
| Progressive ratio test 2 inactive lever presses | 5.3 | 6.1 | 12.1 | -3.2 | -3.1 | -3.1 | 2.2 | -0.0 | 2.0 | -1.2 | -3.5 | -3.1 | -0.5 |
| Intermittent access day 1 locomotion | 5.2 | 5.3 | 10.6 | -2.5 | -2.9 | -2.9 | 2.8 | 1.6 | -0.4 | 1.0 | -2.4 | -3.3 | 1.3 |
| One hour access (shock baseline) | 5.1 | 5.9 | 11.3 | -2.9 | -3.0 | -3.0 | 1.7 | -0.5 | 2.6 | -1.9 | -3.4 | -2.5 | -1.2 |
| Intermittent access day 15 total infusions | 4.6 | 5.2 | 10.0 | -2.8 | -3.0 | -3.0 | 1.9 | -0.1 | 2.0 | -1.3 | -3.2 | -2.6 | -0.5 |
| One hour access (0.3 mA shock) | 4.6 | 5.4 | 12.4 | -2.6 | -2.8 | -2.8 | 1.6 | -0.7 | 2.0 | -1.8 | -3.5 | -2.8 | -1.2 |
| Intermittent access total infusions | 4.4 | 4.9 | 9.1 | -2.7 | -3.0 | -3.0 | 2.5 | 1.0 | 0.7 | 0.1 | -2.6 | -2.9 | 0.7 |
| Lifetime Intake | 4.2 | 4.7 | 8.8 | -2.6 | -2.9 | -2.9 | 2.5 | 1.1 | 0.4 | 0.4 | -2.5 | -3.0 | 0.9 |
| Short access day 1 total infusions | 4.2 | 4.4 | 8.9 | -2.5 | -2.8 | -2.8 | 2.4 | 1.1 | 0.2 | 0.6 | -2.3 | -3.0 | 1.1 |
| Conditioned locomotion | 3.9 | 4.7 | 9.5 | -1.8 | -1.6 | -1.6 | 0.1 | -2.2 | 3.1 | -2.9 | -3.0 | -1.4 | -2.3 |
| Intermittent access terminal intake (last 3 days) | 3.9 | 4.2 | 7.7 | -2.6 | -2.8 | -2.8 | 1.9 | 0.3 | 1.7 | -0.8 | -2.7 | -2.4 | -0.2 |
| Delay discounting water rate 12 sec | 3.6 | 5.3 | 11.7 | -1.1 | -0.3 | -0.3 | -0.9 | -3.3 | 2.8 | -3.4 | -3.1 | -1.3 | -3.0 |
| Short access day 1 locomotion | 3.3 | 3.5 | 6.9 | -2.0 | -2.4 | -2.4 | 2.2 | 1.3 | -0.3 | 0.8 | -1.9 | -2.6 | 1.1 |
| Extensor digitorum longus weight | 3.2 | 12.9 | 32.7 | 3.9 | 3.1 | 3.1 | -2.0 | 1.7 | -4.9 | 3.5 | 5.7 | 3.9 | 2.1 |
| Intermittent access day 15 total locomotion | 3.2 | 3.4 | 6.2 | -2.3 | -2.5 | -2.5 | 1.6 | 0.2 | 1.4 | -0.8 | -2.5 | -2.1 | -0.2 |
| Conditioned reinforcement - inactives | 3.1 | 3.6 | 6.7 | -2.1 | -1.9 | -1.9 | 0.8 | -1.1 | 2.5 | -2.1 | -2.6 | -1.5 | -1.6 |
| Total zone transitions, hab. session 2 | 3.1 | 4.0 | 10.1 | -1.1 | -0.5 | -0.5 | 2.1 | 2.9 | -2.3 | 3.0 | 0.6 | -1.1 | 3.2 |
| Delta time to tail flick, test, before/after SA | 3.1 | 2.8 | 4.4 | 1.5 | 2.0 | 2.0 | -2.0 | -1.3 | 0.8 | -1.2 | 1.5 | 2.1 | -1.6 |
| Reaction time premature initiations | 3.0 | 4.3 | 9.0 | 2.2 | 3.0 | 3.0 | -2.0 | -0.4 | -1.8 | 0.5 | 2.7 | 2.3 | -0.2 |
| Short access total infusions | 2.9 | 3.2 | 6.5 | -1.9 | -2.2 | -2.2 | 2.1 | 1.4 | -0.6 | 1.1 | -1.6 | -2.5 | 1.4 |
| Bone: cortical thickness | 2.9 | 4.8 | 8.9 | 3.0 | 2.3 | 2.3 | -2.6 | -1.0 | -1.5 | 0.0 | 2.9 | 3.0 | -0.4 |
| BMI with tail | 2.8 | 9.2 | 23.9 | -0.2 | -1.1 | -1.1 | 2.5 | 4.1 | -4.1 | 4.9 | 1.8 | -0.8 | 4.6 |
| Retroperitoneal fat weight | 2.8 | 9.4 | 21.1 | -4.0 | -3.6 | -3.6 | 2.2 | -0.8 | 3.0 | -1.7 | -4.6 | -3.6 | -0.8 |
| Indifference point function ln k | 2.8 | 4.0 | 12.0 | -1.7 | -1.9 | -1.9 | 0.7 | -1.7 | 1.8 | -1.9 | -3.5 | -2.1 | -1.6 |
| Indifference point function log k | 2.8 | 4.0 | 12.0 | -1.7 | -1.9 | -1.9 | 0.7 | -1.7 | 1.8 | -1.9 | -3.5 | -2.1 | -1.6 |
| Delay discounting water rate 0 sec | 2.8 | 4.4 | 11.0 | -1.0 | -0.1 | -0.1 | -1.1 | -2.9 | 3.1 | -3.3 | -2.1 | -0.2 | -2.9 |
| Short access day 10 total locomotion | 2.8 | 3.1 | 5.1 | -1.7 | -2.2 | -2.2 | 2.1 | 1.4 | -0.8 | 0.9 | -1.7 | -2.3 | 1.4 |
| Short access total locomotion | 2.8 | 2.9 | 5.3 | -1.7 | -2.1 | -2.1 | 2.1 | 1.4 | -0.8 | 1.0 | -1.5 | -2.3 | 1.3 |
| Sum of active levers in priming session hrs 5-6 | 2.8 | 2.7 | 7.3 | 1.3 | 1.5 | 1.5 | -2.0 | -1.2 | 1.1 | -1.5 | 1.7 | 2.7 | -1.5 |
| Progressive ratio test 2 active lever presses | 2.6 | 2.7 | 4.9 | -2.0 | -2.2 | -2.2 | 1.4 | -0.0 | 1.4 | -0.9 | -2.2 | -1.9 | -0.3 |
| Progressive ratio test 2 breakpoint | 2.6 | 2.8 | 5.8 | -1.9 | -2.0 | -2.0 | 1.0 | -0.6 | 1.8 | -1.5 | -2.4 | -1.8 | -0.9 |
| Locomotion in novel chamber | 2.6 | 3.2 | 6.3 | -1.9 | -2.0 | -2.0 | 0.8 | -1.1 | 2.1 | -1.9 | -2.5 | -1.4 | -1.5 |
| Mg content in liver | 2.6 | 2.7 | 4.5 | -1.1 | -1.4 | -1.4 | 2.1 | 2.1 | -1.3 | 2.1 | -0.3 | -1.5 | 2.1 |
| Intermitt. access escalation Index | 2.5 | 2.2 | 5.3 | -1.8 | -1.8 | -1.8 | 1.5 | 0.1 | 0.4 | 0.1 | -2.2 | -2.3 | 0.5 |
| Compulsive drug intake | 2.5 | 2.5 | 4.6 | 2.1 | 2.1 | 2.1 | -1.4 | -0.2 | -1.6 | 0.7 | 1.9 | 1.6 | 0.2 |
| Time >=10cm from walls, locomotor time 1 | 2.4 | 2.4 | 4.4 | -2.0 | -2.1 | -2.1 | 2.0 | 1.4 | 0.3 | 0.6 | -1.3 | -1.6 | 1.0 |
| Pavlov. Cond. magazine entry number | 2.3 | 2.9 | 7.2 | -1.1 | -1.0 | -1.0 | -0.2 | -2.2 | 2.0 | -2.1 | -2.7 | -1.4 | -1.8 |
| Bone: connectivity density | 2.3 | 3.5 | 9.0 | -0.7 | 0.0 | 0.0 | 1.7 | 3.0 | -2.1 | 2.8 | 1.3 | -0.6 | 3.0 |
| Progressive ratio | 2.3 | 2.6 | 6.6 | -0.4 | -0.5 | -0.5 | 1.6 | 2.5 | -1.9 | 2.6 | 0.9 | -0.6 | 2.4 |
| Sr content in liver | 2.3 | 2.1 | 3.9 | 1.6 | 1.9 | 1.9 | -1.6 | -0.6 | -0.1 | -0.3 | 2.0 | 2.0 | -0.9 |
| Glucose | 2.2 | 3.4 | 6.4 | -2.3 | -2.2 | -2.2 | 2.2 | 1.0 | 0.6 | 0.5 | -2.2 | -2.5 | 0.9 |
| Delay discounting water rate 24 sec | 2.2 | 3.1 | 7.2 | -0.6 | -0.3 | -0.3 | -0.8 | -2.6 | 2.2 | -2.7 | -2.1 | -0.4 | -2.5 |
| Short access day 1 total inactive lever presses | 2.2 | 2.5 | 5.4 | -2.0 | -1.8 | -1.8 | 1.3 | -0.2 | 1.4 | -0.7 | -2.3 | -2.1 | -0.2 |
| Total heroin consumption | 2.2 | 2.6 | 7.1 | 1.6 | 1.7 | 1.7 | -0.9 | 0.8 | -1.2 | 1.3 | 2.7 | 2.0 | 1.2 |
| Parametrial fat weight | 2.1 | 4.1 | 8.0 | -2.8 | -2.7 | -2.7 | 2.0 | 0.4 | 1.2 | 0.0 | -2.6 | -2.6 | 0.5 |
| Bone: endosteal perimeter | 2.1 | 4.3 | 8.1 | -2.8 | -2.5 | -2.5 | 2.7 | 1.6 | 1.1 | 0.4 | -2.2 | -2.4 | 1.3 |
| Bone: minimum diameter | 2.1 | 3.9 | 6.4 | -2.1 | -2.5 | -2.5 | 2.5 | 1.7 | -0.0 | 1.1 | -1.7 | -2.3 | 1.7 |
| Bone surface | 2.0 | 3.4 | 9.3 | -0.2 | 0.6 | 0.6 | 1.3 | 3.0 | -1.7 | 2.7 | 2.1 | 0.3 | 2.8 |
| Active lever presses in extinction session 6 | 2.0 | 1.9 | 4.9 | 1.7 | 1.5 | 1.5 | -1.5 | -0.5 | -0.2 | -0.4 | 1.9 | 2.2 | -0.5 |
| Run reversals in cocaine runway, males | 2.0 | 2.0 | 4.1 | 1.2 | 1.0 | 1.0 | -1.9 | -2.0 | 0.9 | -1.8 | 0.2 | 1.2 | -1.8 |
| Delay discounting total patch changes 12 sec | 1.9 | 2.6 | 6.4 | 1.1 | 1.5 | 1.5 | -0.3 | 1.4 | -2.0 | 1.9 | 2.5 | 1.4 | 1.3 |
| Saline control response | 1.9 | 2.6 | 5.0 | 1.6 | 1.8 | 1.8 | -0.3 | 1.2 | -2.1 | 1.7 | 2.2 | 1.1 | 1.3 |
| Length with tail | 1.8 | 6.5 | 11.9 | 3.4 | 3.1 | 3.1 | -2.7 | -0.7 | -1.8 | 0.3 | 3.5 | 3.4 | -0.1 |
| Reaction time premature initiation rate | 1.8 | 2.4 | 5.2 | 1.6 | 2.3 | 2.3 | -1.2 | 0.0 | -1.7 | 0.8 | 1.9 | 1.4 | 0.2 |
| Bone: apparent density | 1.8 | 3.0 | 7.2 | -1.2 | -0.8 | -0.8 | 2.1 | 2.7 | -1.3 | 2.3 | 0.1 | -1.4 | 2.6 |
| Extinction: sum of active levers before priming | 1.8 | 1.8 | 4.4 | 1.0 | 0.6 | 0.6 | -0.0 | 1.4 | -1.6 | 1.8 | 2.1 | 1.3 | 1.6 |
| Body weight | 1.7 | 7.1 | 16.2 | 2.4 | 1.7 | 1.7 | -0.4 | 2.2 | -4.0 | 3.3 | 3.8 | 2.1 | 2.9 |
| Epididymis fat weight | 1.7 | 3.9 | 8.1 | -2.7 | -2.4 | -2.4 | 1.5 | -0.4 | 2.0 | -1.0 | -2.8 | -2.3 | -0.1 |
| Baseline Anxiety | 1.7 | 1.7 | 3.6 | 1.5 | 1.9 | 1.9 | -1.2 | -0.0 | -0.6 | 0.2 | 1.9 | 1.7 | 0.0 |
| Total sessions with >9 infusions | 1.7 | 1.9 | 4.1 | -1.5 | -1.9 | -1.9 | 1.5 | 0.6 | -0.1 | 0.4 | -1.6 | -2.0 | 0.7 |
| Time to tail flick, test, before self-admin | 1.7 | 1.6 | 3.0 | -0.8 | -1.3 | -1.3 | 1.5 | 1.0 | -1.3 | 1.1 | -1.1 | -1.7 | 1.4 |
| Run reversals in cocaine runway, females | 1.7 | 1.7 | 5.6 | 0.1 | -0.6 | -0.6 | 0.9 | 1.4 | -2.4 | 2.1 | 0.3 | -0.9 | 1.6 |
| Soleus weight | 1.6 | 4.6 | 12.5 | -1.3 | -2.3 | -2.3 | 0.5 | -2.1 | 2.4 | -2.4 | -3.5 | -1.7 | -1.5 |
| Delay discounting time to switch 0 sec | 1.6 | 2.5 | 6.3 | 0.1 | -0.5 | -0.5 | 1.3 | 2.5 | -2.0 | 2.5 | 1.2 | -0.1 | 2.3 |
| Delay discounting water rate 6 sec | 1.6 | 2.3 | 6.5 | -0.3 | 0.1 | 0.1 | -1.0 | -2.6 | 1.4 | -2.4 | -1.8 | -0.4 | -2.0 |
| Pavlov. Cond. magazine entry latency | 1.6 | 1.8 | 3.8 | 0.7 | 0.6 | 0.6 | 0.3 | 1.8 | -1.8 | 1.9 | 1.9 | 0.8 | 1.5 |
| Progressive ratio test 1 active lever presses | 1.6 | 1.6 | 3.3 | -1.5 | -1.6 | -1.6 | 1.0 | -0.0 | 1.1 | -0.6 | -1.8 | -1.7 | -0.3 |
| Bone: cortical thickness | 1.6 | 1.8 | 3.5 | 1.9 | 1.5 | 1.5 | -1.8 | -1.1 | -1.0 | -0.2 | 1.4 | 1.5 | -0.9 |
| Bone: trabecular tissue density | 1.6 | 2.3 | 4.9 | -0.8 | -1.2 | -1.2 | -0.1 | -1.7 | 2.2 | -2.2 | -2.1 | -0.6 | -1.2 |
| Rb content in liver | 1.6 | 2.0 | 4.7 | -1.3 | -1.6 | -1.6 | 1.8 | 1.0 | 0.1 | 0.6 | -1.7 | -2.2 | 1.0 |
| Heart weight | 1.5 | 2.2 | 5.5 | -2.2 | -1.4 | -1.4 | 1.3 | -0.1 | 1.0 | -0.5 | -2.3 | -2.2 | -0.4 |
| Indifference point AUC | 1.5 | 1.7 | 5.0 | 1.4 | 1.3 | 1.3 | -0.9 | 0.5 | -1.1 | 0.9 | 2.2 | 1.8 | 0.6 |
| Locomotion velocity, session 7 | 1.5 | 1.7 | 3.3 | -1.1 | -1.8 | -1.8 | 1.3 | 1.0 | -0.7 | 1.1 | -0.8 | -1.3 | 1.4 |
| Total locomotion distance, hab. session 2 | 1.5 | 2.0 | 3.5 | -1.1 | -1.3 | -1.3 | 1.7 | 1.6 | -1.1 | 1.6 | -0.6 | -1.4 | 1.9 |
| Locomotion velocity, hab. session 2 | 1.5 | 2.0 | 3.1 | -1.3 | -1.6 | -1.6 | 1.8 | 1.5 | -0.8 | 1.4 | -0.8 | -1.4 | 1.8 |
| Bone: marrow area | 1.5 | 3.1 | 4.9 | -2.1 | -2.2 | -2.2 | 2.2 | 1.1 | 0.4 | 0.6 | -2.0 | -2.2 | 1.2 |
| BMI without tail | 1.4 | 2.9 | 7.8 | 0.1 | -0.7 | -0.7 | 1.2 | 2.1 | -2.6 | 2.8 | 0.9 | -0.6 | 2.6 |
| Tail length | 1.4 | 4.1 | 6.9 | 2.6 | 2.5 | 2.5 | -2.6 | -1.8 | -0.7 | -1.0 | 1.9 | 2.5 | -1.2 |
| Length without tail | 1.4 | 3.0 | 7.5 | 2.0 | 2.1 | 2.1 | -1.2 | 0.5 | -1.5 | 1.0 | 2.7 | 2.2 | 0.7 |
| Conditioned locomotion | 1.4 | 1.7 | 3.1 | 1.7 | 1.3 | 1.3 | -1.4 | -0.4 | -1.4 | 0.4 | 1.7 | 1.7 | 0.3 |
| Bone volume | 1.4 | 2.3 | 7.0 | -0.8 | -0.3 | -0.3 | 1.7 | 2.6 | -1.0 | 2.1 | 0.9 | -0.4 | 2.4 |
| Bone: endosteal estimation | 1.4 | 3.0 | 4.7 | -2.1 | -2.2 | -2.2 | 2.1 | 1.1 | 0.4 | 0.5 | -1.9 | -2.1 | 1.2 |
| Bone: maximum force | 1.4 | 2.5 | 5.8 | 0.4 | 0.3 | 0.3 | 0.7 | 2.2 | -2.0 | 2.2 | 2.0 | 0.8 | 2.4 |
| Bone: trabecular number | 1.4 | 2.2 | 6.2 | -1.1 | -0.6 | -0.6 | 1.8 | 2.5 | -0.8 | 1.9 | 0.4 | -0.9 | 2.3 |
| Locomotion in novel chamber post-restriction | 1.4 | 1.7 | 3.8 | -1.4 | -1.3 | -1.3 | 0.5 | -0.8 | 1.4 | -1.3 | -2.0 | -1.3 | -1.1 |
| K content in liver | 1.4 | 1.4 | 3.7 | 0.3 | -0.3 | -0.3 | 0.8 | 1.6 | -1.9 | 1.9 | 1.0 | 0.0 | 1.6 |
| Delay discounting total patch changes 24 sec | 1.3 | 1.6 | 3.8 | 1.2 | 1.7 | 1.7 | -1.0 | 0.3 | -1.1 | 0.7 | 1.9 | 1.5 | 0.3 |
| Post-drug Anxiety | 1.3 | 1.4 | 3.1 | 1.3 | 1.5 | 1.5 | -1.3 | -0.4 | 0.3 | -0.4 | 1.5 | 1.8 | -0.7 |
| Progressive ratio test 1 breakpoint | 1.3 | 1.3 | 2.8 | -1.3 | -1.4 | -1.4 | 0.8 | -0.2 | 1.1 | -0.7 | -1.7 | -1.5 | -0.5 |
| Locomotion velocity, session 2 | 1.3 | 1.5 | 3.9 | 1.2 | 0.5 | 0.5 | -0.1 | 1.0 | -2.0 | 1.6 | 1.7 | 1.0 | 1.4 |
| Bone: elastic work | 1.3 | 1.7 | 2.9 | 1.6 | 1.6 | 1.6 | -1.7 | -1.0 | -1.3 | -0.0 | 1.4 | 1.5 | -0.1 |
| Breakpoint value in progressive ratio session | 1.3 | 1.4 | 4.4 | 1.3 | 1.1 | 1.1 | -0.7 | 0.7 | -0.8 | 0.8 | 2.1 | 1.7 | 0.7 |
| Vertical activity count, locomotor time 2 | 1.3 | 1.4 | 2.3 | 1.2 | 1.4 | 1.4 | -1.5 | -1.5 | -0.2 | -1.0 | 0.5 | 1.1 | -1.4 |
| Weight adjusted by age | 1.3 | 1.5 | 3.7 | 1.5 | 1.2 | 1.2 | -1.0 | 0.2 | -1.2 | 0.5 | 1.9 | 1.7 | 0.5 |
| Intraocular pressure | 1.2 | 1.7 | 6.0 | -0.8 | -0.2 | -0.2 | -0.7 | -1.4 | 2.5 | -2.0 | -0.7 | 0.3 | -1.8 |
| Intermitt. access day 1 inactive lever presses | 1.2 | 1.3 | 2.7 | -1.3 | -1.3 | -1.3 | 0.8 | -0.3 | 1.5 | -1.0 | -1.6 | -1.0 | -0.6 |
| Intermitt. access day 15 inactive lever presses | 1.2 | 1.3 | 2.2 | -1.2 | -1.4 | -1.4 | 0.6 | -0.3 | 1.5 | -1.2 | -1.5 | -0.8 | -0.7 |
| Locomotion distance, session 1 | 1.2 | 1.5 | 3.9 | -0.3 | -0.3 | -0.3 | 1.1 | 1.6 | -1.9 | 1.8 | 0.3 | -0.7 | 2.0 |
| Bone: maximum moment | 1.2 | 2.1 | 4.9 | 0.3 | 0.3 | 0.3 | 0.7 | 2.0 | -1.9 | 2.1 | 1.8 | 0.7 | 2.2 |
| Bone: stiffness | 1.2 | 1.9 | 5.0 | -0.1 | 0.0 | 0.0 | 1.0 | 2.2 | -1.4 | 2.0 | 1.5 | 0.4 | 2.0 |
| Bone: trabecular thickness | 1.2 | 1.5 | 2.9 | -1.3 | -1.2 | -1.2 | 1.7 | 1.4 | 0.1 | 0.8 | -1.0 | -1.6 | 1.3 |
| Time to tail flick, vehicle, after self-admin | 1.2 | 1.3 | 4.6 | 0.8 | 0.3 | 0.3 | 0.3 | 1.2 | -2.1 | 1.8 | 1.0 | -0.1 | 1.5 |
| Delay disc. indifference point, 16s delay | 1.2 | 1.2 | 2.3 | -1.5 | -1.5 | -1.5 | 1.3 | 0.8 | 0.5 | 0.0 | -1.2 | -1.2 | 0.4 |
| Seeking ratio, punishment vs. effort | 1.2 | 1.5 | 4.4 | 0.6 | 0.5 | 0.5 | -1.3 | -2.1 | 0.9 | -1.9 | -0.8 | 0.4 | -1.8 |
| Condit. Reinf. active-inactive response ratio | 1.1 | 1.1 | 2.1 | -1.4 | -1.4 | -1.4 | 0.9 | 0.3 | 1.4 | -0.6 | -1.0 | -0.6 | 0.4 |
| Condit. Reinf. inactive responses | 1.1 | 1.4 | 3.4 | -0.7 | 0.1 | 0.1 | 1.2 | 1.8 | -1.4 | 1.8 | 0.3 | -1.0 | 1.5 |
| Short access day 10 total inactive lever presses | 1.1 | 1.2 | 3.7 | -1.0 | -1.0 | -1.0 | 0.5 | -0.8 | 1.0 | -1.1 | -1.9 | -1.2 | -0.9 |
| Locomotion distance, session 2 | 1.1 | 1.5 | 4.8 | 0.5 | -0.1 | -0.1 | 0.6 | 1.3 | -2.2 | 1.8 | 0.8 | -0.1 | 2.0 |
| Total zone transitions, NPP test | 1.1 | 1.5 | 3.8 | 0.4 | 0.4 | 0.4 | 0.5 | 1.5 | -2.0 | 1.8 | 1.4 | 0.4 | 1.8 |
| Delay disc. indifference point, 0s delay | 1.1 | 1.2 | 3.1 | -0.8 | -0.8 | -0.8 | 1.2 | 0.6 | -1.5 | 0.9 | -1.2 | -1.7 | 1.0 |
| Delay discounting water rate 18 sec | 1.0 | 1.4 | 3.8 | -0.4 | -0.5 | -0.5 | -0.1 | -1.6 | 1.2 | -1.6 | -1.9 | -1.0 | -1.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.0 | 1.2 | 3.4 | 0.9 | 0.3 | 0.3 | 0.2 | 1.5 | -1.1 | 1.4 | 1.8 | 1.1 | 1.2 |
| Bone: elastic displacement | 1.0 | 1.1 | 3.8 | 0.6 | 0.7 | 0.7 | -1.4 | -1.9 | 0.4 | -1.5 | -0.4 | 0.5 | -1.2 |
| Bone: final force | 1.0 | 1.7 | 4.3 | 1.5 | 1.2 | 1.2 | -0.5 | 0.9 | -1.6 | 1.2 | 2.1 | 1.3 | 1.1 |
| Rest time, locomotor task time 2 | 1.0 | 1.2 | 3.3 | -1.1 | -1.3 | -1.3 | 0.6 | -0.6 | 1.1 | -0.9 | -1.8 | -1.2 | -0.5 |
| Cd content in liver | 1.0 | 1.1 | 3.7 | -0.8 | -0.4 | -0.4 | -0.2 | -0.9 | 1.9 | -1.7 | -1.1 | -0.0 | -1.2 |
| Locomotor testing distance | 0.9 | 1.4 | 3.6 | -0.3 | 0.6 | 0.6 | -0.7 | -1.9 | 0.7 | -1.7 | -1.5 | -0.7 | -1.7 |
| Light reinforcement 2 | 0.9 | 1.2 | 4.4 | -0.8 | -0.8 | -0.8 | 0.1 | -0.7 | 2.1 | -1.6 | -1.1 | -0.1 | -1.2 |
| Condit. Reinf. active responses | 0.9 | 1.2 | 2.8 | -1.5 | -0.6 | -0.6 | 1.5 | 1.7 | -0.1 | 1.0 | -0.2 | -1.0 | 1.6 |
| Intermittent access intake day 1-15 change | 0.9 | 0.9 | 2.5 | -0.0 | -0.0 | -0.0 | -0.7 | -1.2 | 1.5 | -1.6 | -0.4 | 0.6 | -1.3 |
| Locomotion velocity, session 8 | 0.9 | 1.1 | 2.5 | 1.1 | 1.6 | 1.6 | -0.8 | -0.1 | -1.1 | 0.4 | 1.2 | 1.0 | 0.0 |
| Bone: final moment | 0.9 | 1.5 | 3.7 | 1.3 | 1.1 | 1.1 | -0.4 | 0.8 | -1.5 | 1.2 | 1.9 | 1.2 | 1.0 |
| Mn content in liver | 0.9 | 1.0 | 3.3 | 0.1 | 0.8 | 0.8 | -0.3 | 1.3 | -0.8 | 0.9 | 1.8 | 1.3 | 1.0 |
| Locomotor activity | 0.8 | 1.2 | 3.2 | -0.4 | 0.6 | 0.6 | -0.8 | -1.8 | 0.9 | -1.7 | -1.2 | -0.3 | -1.5 |
| Reaction time mean minus median | 0.8 | 1.1 | 4.1 | 0.6 | 0.7 | 0.7 | -0.3 | 1.1 | -0.7 | 1.0 | 2.0 | 1.5 | 0.6 |
| Pavlov. Cond. index score | 0.8 | 1.0 | 2.8 | 0.7 | 0.2 | 0.2 | 0.2 | 1.4 | -0.9 | 1.2 | 1.7 | 1.0 | 1.0 |
| Intermittent access intake escalation 2 | 0.8 | 0.8 | 2.0 | 0.2 | 0.2 | 0.2 | -0.9 | -1.1 | 1.3 | -1.4 | -0.1 | 0.8 | -1.2 |
| Context. condit. distance diff. score | 0.8 | 1.0 | 2.8 | -1.1 | -1.0 | -1.0 | 0.6 | -0.4 | 0.8 | -0.6 | -1.7 | -1.3 | -0.8 |
| Stereotopy head waving bouts, day 3 | 0.8 | 0.9 | 2.1 | -0.8 | -1.1 | -1.1 | 1.1 | 0.6 | -0.3 | 0.6 | -1.1 | -1.4 | 0.9 |
| Stereotopy head waving duration, day 3 | 0.8 | 1.0 | 2.3 | -1.1 | -1.2 | -1.2 | 1.1 | 0.4 | 0.4 | 0.2 | -1.4 | -1.5 | 0.5 |
| Stereotopy head waving duration, day 7 | 0.8 | 1.0 | 3.4 | -0.6 | -0.3 | -0.3 | 1.1 | 1.9 | -0.3 | 1.4 | 0.6 | -0.2 | 1.5 |
| Pavlov. Cond. magazine entry latency | 0.8 | 1.1 | 2.1 | -1.2 | -1.0 | -1.0 | 1.3 | 1.4 | -0.3 | 1.1 | -0.2 | -0.7 | 1.3 |
| Area under the delay curve | 0.8 | 0.9 | 1.6 | -0.7 | -0.7 | -0.7 | 1.2 | 1.0 | -0.9 | 1.0 | -0.6 | -1.3 | 1.1 |
| Rest time, locomotor task time 1 | 0.8 | 0.9 | 2.3 | -0.5 | -0.4 | -0.4 | -0.2 | -1.1 | 1.5 | -1.5 | -1.1 | -0.2 | -1.3 |
| Latency to leave start box in cocaine runway | 0.8 | 0.9 | 1.4 | -0.9 | -1.1 | -1.1 | 1.2 | 1.2 | -0.3 | 0.9 | -0.3 | -0.8 | 0.9 |
| Co content in liver | 0.8 | 0.9 | 1.9 | 0.7 | 0.6 | 0.6 | -1.1 | -1.4 | 0.7 | -1.4 | -0.9 | -0.1 | -1.4 |
| Na content in liver | 0.8 | 0.8 | 2.1 | 0.9 | 1.0 | 1.0 | -1.1 | -0.2 | 0.1 | -0.4 | 1.2 | 1.5 | -0.6 |
| Tibia length | 0.7 | 1.8 | 6.3 | 1.5 | 1.0 | 1.0 | -1.5 | -0.6 | 0.6 | -0.7 | 2.0 | 2.5 | -0.3 |
| Delay discounting total patch changes 6 sec | 0.7 | 1.0 | 2.1 | 0.3 | 0.8 | 0.8 | 0.3 | 1.3 | -1.4 | 1.4 | 1.2 | 0.4 | 1.0 |
| Reaction time mean minus median AUC | 0.7 | 0.9 | 3.1 | 0.8 | 0.9 | 0.9 | -1.0 | 0.1 | -0.4 | 0.3 | 1.8 | 1.6 | -0.3 |
| Condit. Reinf. lever presses | 0.7 | 1.0 | 2.8 | 0.4 | 0.5 | 0.5 | 0.3 | 1.5 | -0.7 | 1.1 | 1.7 | 1.0 | 1.1 |
| Condit. Reinf. lever reinforcers received | 0.7 | 0.9 | 2.8 | -1.1 | -0.3 | -0.3 | 1.3 | 1.7 | -0.2 | 1.0 | 0.1 | -0.6 | 1.5 |
| Progressive ratio test 1 inactive lever presses | 0.7 | 0.8 | 1.8 | -1.1 | -1.1 | -1.1 | 0.9 | 0.2 | -0.1 | -0.1 | -1.3 | -1.3 | 0.1 |
| Stereotopy head waving bouts, day 7 | 0.7 | 0.8 | 1.8 | -1.3 | -1.0 | -1.0 | 1.1 | 0.9 | 0.9 | 0.2 | -0.7 | -0.7 | 0.5 |
| Distance moved, locomotor task time 1 | 0.7 | 0.8 | 1.8 | -0.2 | -0.5 | -0.5 | 0.9 | 1.1 | -1.3 | 1.2 | 0.1 | -0.6 | 1.2 |
| Distance moved, locomotor task time 2 | 0.7 | 0.8 | 1.6 | 1.1 | 1.1 | 1.1 | -0.6 | 0.1 | -1.1 | 0.4 | 1.3 | 1.2 | 0.1 |
| Mean time between licks in bursts | 0.6 | 0.8 | 2.4 | 0.8 | 1.5 | 1.5 | -0.6 | -0.0 | -1.1 | 0.5 | 0.8 | 0.4 | 0.3 |
| Std. dev. time between licks in bursts | 0.6 | 0.7 | 1.5 | 0.9 | 1.1 | 1.1 | -1.0 | -1.2 | -0.4 | -0.4 | 0.1 | 0.3 | -0.7 |
| Locomotor testing rearing | 0.6 | 0.9 | 3.2 | -1.2 | 0.1 | 0.1 | 0.5 | -0.6 | 0.6 | -0.7 | -1.8 | -1.6 | -0.5 |
| Reaction time num false alarms AUC | 0.6 | 0.8 | 1.4 | 1.2 | 1.1 | 1.1 | -1.2 | -1.0 | -1.0 | -0.0 | 0.6 | 0.6 | -0.5 |
| Reaction time trials on left | 0.6 | 0.9 | 1.8 | 0.7 | 1.1 | 1.1 | -1.3 | -0.8 | -0.1 | -0.5 | 1.0 | 1.3 | -0.6 |
| Reaction time omissions | 0.6 | 0.8 | 2.6 | 0.9 | 0.6 | 0.6 | -0.8 | 0.2 | -0.8 | 0.6 | 1.6 | 1.3 | 0.1 |
| Reaction time trials completed | 0.6 | 0.9 | 1.8 | 0.7 | 1.1 | 1.1 | -1.3 | -0.8 | -0.1 | -0.5 | 1.0 | 1.3 | -0.6 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.8 | 2.2 | -1.5 | -0.8 | -0.8 | 1.1 | 0.9 | 0.9 | -0.0 | -0.6 | -0.7 | 0.7 |
| Pavlov. Cond. change in total contacts | 0.6 | 0.9 | 2.7 | 0.0 | -0.4 | -0.4 | 0.6 | 1.7 | -0.2 | 1.1 | 1.4 | 0.9 | 1.2 |
| Pavlov. Cond. latency score | 0.6 | 0.8 | 2.3 | 0.6 | 0.0 | 0.0 | 0.2 | 1.2 | -0.8 | 1.1 | 1.5 | 1.0 | 0.9 |
| Pavlov. Cond. intertrial magazine entries | 0.6 | 0.8 | 1.7 | -0.9 | -0.8 | -0.8 | 0.2 | -0.7 | 1.2 | -1.0 | -1.3 | -0.8 | -0.8 |
| Incentive Sensitization - Breakpoint | 0.6 | 0.6 | 1.5 | -0.9 | -1.2 | -1.2 | 0.7 | 0.2 | 0.5 | -0.4 | -0.8 | -0.7 | 0.1 |
| Degree of sensitization distance | 0.6 | 0.6 | 1.2 | -0.2 | -0.6 | -0.6 | 0.7 | 0.6 | -1.1 | 1.0 | -0.2 | -0.9 | 1.0 |
| Bone: cortical porosity | 0.6 | 0.6 | 1.7 | -0.2 | -0.3 | -0.3 | 0.9 | 1.1 | -0.8 | 1.1 | -0.0 | -0.7 | 1.3 |
| Bone: cortical porosity | 0.6 | 0.7 | 2.1 | 0.2 | 0.2 | 0.2 | 0.5 | 1.0 | -1.1 | 1.2 | 0.5 | -0.3 | 1.5 |
| Delay disc. indifference point, 4s delay | 0.6 | 0.6 | 1.6 | -0.4 | -0.4 | -0.4 | 0.8 | 0.6 | -0.9 | 0.8 | -0.7 | -1.2 | 0.9 |
| Delay discount exponential model param | 0.6 | 0.7 | 1.1 | 0.5 | 0.6 | 0.6 | -1.0 | -0.9 | 0.9 | -0.9 | 0.5 | 1.1 | -1.0 |
| Right kidney weight | 0.5 | 1.5 | 4.1 | -0.5 | -0.4 | -0.4 | -0.9 | -1.5 | 2.0 | -1.9 | -0.3 | 1.0 | -1.7 |
| Food consumed during 24 hour testing period | 0.5 | 0.5 | 1.1 | 0.7 | 0.5 | 0.5 | -0.6 | -0.9 | 1.0 | -0.9 | 0.3 | 0.8 | -0.8 |
| Times rat made contact with spout | 0.5 | 0.5 | 1.8 | 0.0 | 0.4 | 0.4 | 0.4 | 0.8 | -1.3 | 1.1 | 0.6 | -0.1 | 0.9 |
| Reaction time number correct | 0.5 | 0.7 | 1.5 | 0.6 | 1.0 | 1.0 | -1.2 | -0.7 | -0.1 | -0.5 | 0.9 | 1.2 | -0.5 |
| Reaction time trials correct on left | 0.5 | 0.7 | 1.5 | 0.6 | 1.0 | 1.0 | -1.2 | -0.7 | -0.1 | -0.5 | 0.9 | 1.2 | -0.5 |
| Pavlov. Cond. response bias | 0.5 | 0.7 | 2.4 | 0.7 | 0.6 | 0.6 | -0.0 | 1.0 | -0.4 | 0.8 | 1.5 | 1.0 | 0.6 |
| Intermittent access intake escalation | 0.5 | 0.5 | 1.4 | -0.2 | -0.3 | -0.3 | -0.3 | -0.7 | 1.2 | -1.2 | -0.5 | 0.3 | -0.9 |
| Intermittent access standard deviation | 0.5 | 0.6 | 1.3 | -0.4 | -0.7 | -0.7 | -0.1 | -0.8 | 1.1 | -1.2 | -0.9 | -0.3 | -0.8 |
| Incentive Sensitization - Responses | 0.5 | 0.5 | 1.4 | -0.8 | -1.2 | -1.2 | 0.8 | 0.4 | 0.3 | -0.1 | -0.6 | -0.7 | 0.3 |
| Locomotion velocity, session 3 | 0.5 | 0.5 | 0.8 | -0.6 | -0.9 | -0.9 | 0.9 | 0.7 | -0.6 | 0.7 | -0.5 | -0.7 | 0.8 |
| Time in familiar zone, hab. session 1 | 0.5 | 0.4 | 0.8 | -0.9 | -0.8 | -0.8 | 0.9 | 0.6 | 0.1 | 0.3 | -0.6 | -0.8 | -0.1 |
| Time in novel zone, hab. session 2 | 0.5 | 0.5 | 1.0 | -0.9 | -0.7 | -0.7 | 1.0 | 1.0 | -0.2 | 0.7 | -0.1 | -0.6 | 0.8 |
| Bone: cortical area | 0.5 | 0.7 | 2.0 | 1.2 | 0.6 | 0.6 | -1.0 | -0.3 | -0.3 | -0.1 | 1.3 | 1.4 | -0.1 |
| Delta time in closed arm before/after self-admin | 0.5 | 0.5 | 2.2 | 0.7 | 0.7 | 0.7 | -0.6 | -0.4 | -1.5 | 0.4 | 0.4 | 0.2 | 0.3 |
| Time to tail flick, vehicle, before self-admin | 0.5 | 0.5 | 1.2 | 0.0 | -0.1 | -0.1 | 0.5 | 0.9 | -1.1 | 1.0 | 0.5 | -0.0 | 1.0 |
| Delta time to tail flick, vehicle, before/after SA | 0.5 | 0.5 | 1.4 | 0.5 | 0.2 | 0.2 | 0.3 | 0.7 | -1.2 | 1.0 | 0.5 | -0.1 | 0.9 |
| Ambulatory time after self-admin | 0.5 | 0.6 | 1.3 | -1.1 | -1.0 | -1.0 | 1.0 | 0.7 | 0.7 | 0.1 | -0.5 | -0.4 | 0.4 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 1.3 | -0.2 | -0.2 | -0.2 | 0.7 | 0.6 | -1.1 | 0.8 | -0.4 | -1.0 | 0.8 |
| Delay discount hyperbolic model param | 0.5 | 0.6 | 1.0 | 0.4 | 0.5 | 0.5 | -0.9 | -0.8 | 0.9 | -0.8 | 0.5 | 1.0 | -0.9 |
| Change in fecal boli incidents, locomotor task | 0.5 | 0.5 | 2.7 | 0.0 | 0.2 | 0.2 | 0.5 | 0.5 | -1.6 | 1.0 | -0.1 | -0.6 | 0.7 |
| Bouts of movement, locomotor time 1 | 0.5 | 0.6 | 1.6 | 0.7 | 0.9 | 0.9 | -0.4 | 0.4 | -0.3 | 0.3 | 1.3 | 1.1 | 0.1 |
| Seeking ratio, delayed vs. immediate footshock | 0.5 | 0.6 | 1.0 | -0.5 | -0.5 | -0.5 | 1.0 | 0.9 | -1.0 | 0.9 | -0.3 | -0.8 | 0.7 |
| Se content in liver | 0.5 | 0.6 | 1.3 | -1.1 | -0.9 | -0.9 | 1.0 | 0.6 | 0.5 | 0.3 | -0.1 | -0.4 | 1.1 |
| Zn content in liver | 0.5 | 0.6 | 1.3 | 1.0 | 0.3 | 0.3 | -0.1 | 0.3 | -1.1 | 1.0 | 1.1 | 0.7 | 0.9 |
| Left kidney weight | 0.4 | 1.3 | 2.2 | -0.7 | -1.3 | -1.3 | -0.3 | -1.3 | 1.5 | -1.5 | -1.2 | -0.0 | -1.1 |
| Water consumed over 24 hours | 0.4 | 0.5 | 1.2 | 0.3 | 1.1 | 1.1 | -0.1 | 0.3 | -0.7 | 0.6 | 0.9 | 0.4 | 0.4 |
| Reaction time num false alarms | 0.4 | 0.5 | 1.7 | 0.7 | 0.7 | 0.7 | -1.0 | -1.3 | -0.5 | -0.5 | -0.1 | 0.1 | -0.7 |
| Reaction time trials AUC | 0.4 | 0.6 | 1.2 | 0.5 | 1.0 | 1.0 | -1.1 | -0.7 | -0.1 | -0.5 | 0.8 | 1.1 | -0.5 |
| Social response proportion | 0.4 | 0.5 | 1.4 | 0.1 | 0.7 | 0.7 | 0.4 | 1.2 | -0.5 | 0.8 | 0.8 | 0.2 | 0.7 |
| Social time | 0.4 | 0.6 | 1.5 | 1.2 | 1.2 | 1.2 | -0.6 | -0.0 | -0.5 | 0.1 | 0.7 | 0.5 | 0.0 |
| Cocaine response after cond. corrected | 0.4 | 0.4 | 1.5 | -0.7 | -0.6 | -0.6 | 0.2 | -0.5 | 0.1 | -0.4 | -1.2 | -1.0 | -0.4 |
| Cocaine response after cond. not corrected | 0.4 | 0.4 | 1.3 | -0.7 | -0.5 | -0.5 | 0.5 | -0.1 | 0.2 | -0.2 | -1.1 | -1.1 | -0.3 |
| Number of responses in last shaping day | 0.4 | 0.4 | 1.0 | -0.4 | -0.3 | -0.3 | -0.0 | -0.7 | 0.9 | -0.7 | -1.0 | -0.9 | -0.7 |
| Locomotion distance, session 7 | 0.4 | 0.5 | 1.6 | -0.2 | -0.6 | -0.6 | 0.5 | 0.4 | -1.2 | 1.0 | -0.2 | -0.8 | 0.8 |
| Incentive salience index mean | 0.4 | 0.5 | 1.5 | 0.1 | -0.4 | -0.4 | 0.5 | 0.9 | -1.2 | 1.0 | 0.4 | 0.0 | 0.9 |
| Time in novel zone, hab. session 1 | 0.4 | 0.4 | 1.0 | 0.7 | 0.8 | 0.8 | -0.7 | -1.0 | 0.1 | -0.7 | -0.2 | 0.2 | -0.5 |
| Total zone transitions, hab. session 1 | 0.4 | 0.5 | 1.6 | 0.6 | 0.2 | 0.2 | -0.0 | 0.6 | -1.3 | 1.0 | 1.0 | 0.5 | 0.8 |
| Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 0.9 | 0.9 | 0.9 | 0.9 | -0.8 | -0.6 | -0.5 | -0.2 | 0.2 | 0.3 | -0.4 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 1.0 | -0.9 | -1.0 | -1.0 | 0.7 | 0.7 | 0.6 | 0.1 | -0.1 | -0.0 | 0.3 |
| Diff in mean of infusions in LGA sessions | 0.4 | 0.4 | 1.0 | 0.5 | 0.8 | 0.8 | -0.8 | -0.2 | 0.2 | -0.2 | 0.9 | 1.0 | -0.3 |
| Vertical activity count, locomotor time 1 | 0.4 | 0.4 | 1.1 | -0.7 | -0.8 | -0.8 | 0.3 | -0.5 | 0.3 | -0.5 | -1.0 | -0.8 | -0.5 |
| Latency to leave start box in cocaine runway, F | 0.4 | 0.4 | 0.7 | -0.5 | -0.8 | -0.8 | 0.8 | 0.9 | -0.6 | 0.7 | -0.2 | -0.5 | 0.7 |
| Delay discounting total patch changes 18 sec | 0.3 | 0.4 | 1.0 | -0.4 | 0.1 | 0.1 | 0.3 | 1.0 | -0.6 | 1.0 | 0.7 | 0.1 | 0.9 |
| Social responses | 0.3 | 0.4 | 1.1 | 0.7 | 1.1 | 1.1 | -0.3 | 0.2 | -0.3 | 0.2 | 0.7 | 0.4 | -0.0 |
| Locomotion velocity, session 1 | 0.3 | 0.3 | 0.5 | 0.6 | 0.7 | 0.7 | -0.6 | -0.7 | -0.3 | -0.3 | 0.1 | 0.4 | -0.6 |
| Locomotion distance, session 8 | 0.3 | 0.4 | 0.9 | -0.6 | -0.9 | -0.9 | 0.7 | 0.3 | -0.4 | 0.4 | -0.7 | -0.7 | 0.4 |
| Degree of sensitization stereotypy | 0.3 | 0.3 | 1.2 | -0.7 | -0.2 | -0.2 | 0.6 | 1.1 | 0.4 | 0.6 | 0.5 | 0.2 | 0.6 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.4 | 1.4 | -0.3 | -1.2 | -1.2 | 0.6 | 0.0 | -0.0 | 0.1 | -0.8 | -0.7 | 0.3 |
| Novel to familiar place preference ratio | 0.3 | 0.3 | 1.1 | -0.2 | -0.2 | -0.2 | 0.5 | 1.0 | 0.1 | 0.6 | 0.8 | 0.5 | 0.5 |
| Total locomotion distance, NPP test | 0.3 | 0.5 | 1.3 | -0.0 | -0.7 | -0.7 | 0.6 | 0.6 | -1.0 | 0.8 | -0.1 | -0.4 | 1.1 |
| Locomotion velocity, NPP test | 0.3 | 0.4 | 1.0 | 0.0 | -0.7 | -0.7 | 0.5 | 0.5 | -0.9 | 0.8 | 0.0 | -0.2 | 1.0 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.3 | 1.0 | -0.1 | -0.2 | -0.2 | -0.4 | -0.7 | 0.8 | -1.0 | -0.3 | 0.2 | -0.9 |
| Bone: cortical tissue density | 0.3 | 0.3 | 0.6 | 0.7 | 0.7 | 0.7 | -0.7 | -0.2 | -0.6 | 0.2 | 0.8 | 0.6 | -0.1 |
| Delta time in open arm before/after self-admin | 0.3 | 0.3 | 2.3 | -0.2 | 0.0 | 0.0 | -0.2 | -0.1 | 1.5 | -0.6 | 0.2 | 0.4 | -0.6 |
| Time in open arm after self-admin | 0.3 | 0.3 | 0.8 | 0.3 | 0.4 | 0.4 | -0.5 | -0.8 | 0.9 | -0.7 | -0.2 | 0.1 | -0.9 |
| Total resting periods, locomotor time 1 | 0.3 | 0.3 | 1.0 | 0.3 | 0.5 | 0.5 | -0.1 | 0.6 | -0.1 | 0.3 | 1.0 | 0.8 | 0.2 |
| Food seeking constrained by brief footshock | 0.3 | 0.4 | 0.9 | 0.8 | 0.8 | 0.8 | -0.5 | -0.1 | -1.0 | 0.4 | 0.7 | 0.6 | 0.1 |
| Mean num. licks in bursts | 0.2 | 0.2 | 0.6 | -0.3 | -0.3 | -0.3 | 0.4 | 0.4 | -0.4 | 0.3 | -0.5 | -0.8 | 0.2 |
| Median of all reaction times | 0.2 | 0.3 | 0.6 | -0.5 | -0.8 | -0.8 | 0.3 | 0.1 | 0.7 | -0.3 | -0.4 | -0.3 | -0.6 |
| Reaction time false alarm rate | 0.2 | 0.2 | 0.5 | 0.7 | 0.4 | 0.4 | -0.5 | -0.7 | -0.7 | -0.1 | -0.1 | -0.1 | -0.4 |
| Std. dev. reaction times | 0.2 | 0.3 | 1.2 | 0.1 | 0.3 | 0.3 | -0.3 | 0.5 | 0.1 | 0.3 | 1.1 | 0.8 | -0.3 |
| Cocaine response before conditioning | 0.2 | 0.2 | 0.6 | 0.4 | 0.3 | 0.3 | 0.2 | 0.8 | 0.2 | 0.3 | 0.8 | 0.5 | -0.0 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 1.0 | 0.8 | 0.5 | 0.5 | -0.4 | 0.1 | 0.3 | -0.1 | 0.9 | 1.0 | -0.2 |
| Conditioned reinforcement - actives | 0.2 | 0.2 | 0.8 | -0.3 | -0.2 | -0.2 | -0.3 | -0.5 | 0.9 | -0.8 | -0.3 | -0.0 | -0.6 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 0.7 | -0.0 | -0.1 | -0.1 | 0.4 | 0.7 | -0.8 | 0.6 | 0.3 | 0.1 | 0.5 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.5 | 0.0 | -0.5 | -0.5 | 0.3 | 0.5 | -0.7 | 0.5 | 0.2 | 0.1 | 0.5 |
| Condit. Reinf. inactive responses | 0.2 | 0.2 | 0.6 | -0.2 | -0.8 | -0.8 | 0.3 | 0.2 | -0.3 | 0.4 | -0.1 | -0.2 | 0.5 |
| Locomotion velocity, hab. session 1 | 0.2 | 0.2 | 0.7 | -0.0 | -0.8 | -0.8 | 0.4 | 0.2 | -0.4 | 0.3 | -0.3 | -0.4 | 0.5 |
| Novelty place preference | 0.2 | 0.3 | 0.9 | -0.5 | -0.4 | -0.4 | 0.6 | 1.0 | 0.4 | 0.5 | 0.4 | 0.2 | 0.4 |
| Time in novel zone, NPP test | 0.2 | 0.2 | 0.8 | -0.5 | -0.3 | -0.3 | 0.6 | 0.9 | 0.3 | 0.4 | 0.3 | 0.1 | 0.4 |
| Bone: cortical apparent density | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | 0.6 | -0.6 | -0.2 | -0.6 | 0.2 | 0.6 | 0.5 | -0.0 |
| Bone: periosteal perimeter | 0.2 | 0.3 | 1.0 | -0.6 | -0.5 | -0.5 | 0.8 | 0.9 | 0.1 | 0.5 | 0.1 | -0.2 | 1.0 |
| Bone: trabecular spacing | 0.2 | 0.2 | 0.9 | 0.1 | 0.1 | 0.1 | -0.5 | -0.9 | 0.0 | -0.6 | -0.4 | 0.0 | -0.9 |
| Time in open arm before self-admin | 0.2 | 0.3 | 1.4 | 0.3 | 0.0 | 0.0 | -0.0 | -0.4 | -1.2 | 0.2 | -0.6 | -0.7 | 0.1 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | -0.4 | -0.5 | -0.5 | 0.6 | 0.2 | 0.1 | 0.1 | -0.5 | -0.6 | 0.3 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 1.3 | -0.5 | -0.4 | -0.4 | -0.1 | 0.1 | 1.1 | -0.5 | 0.2 | 0.3 | -0.3 |
| Bouts of movement, locomotor time 2 | 0.2 | 0.3 | 0.6 | 0.4 | 0.5 | 0.5 | -0.1 | 0.5 | -0.7 | 0.6 | 0.8 | 0.4 | 0.4 |
| Cu content in liver | 0.2 | 0.2 | 0.5 | 0.6 | -0.3 | -0.3 | 0.2 | 0.4 | -0.6 | 0.7 | 0.5 | 0.2 | 0.6 |
| Liver weight, left | 0.1 | 0.1 | 0.5 | 0.0 | -0.2 | -0.2 | -0.3 | -0.6 | 0.2 | -0.3 | -0.3 | 0.1 | -0.7 |
| Liver weight, right | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.4 | -0.4 | 0.0 | -0.2 | -0.0 | -0.5 |
| Number of licking bursts | 0.1 | 0.1 | 0.3 | 0.0 | 0.3 | 0.3 | 0.0 | 0.2 | -0.2 | 0.3 | 0.6 | 0.4 | 0.3 |
| Indifference point 0 sec | 0.1 | 0.2 | 0.9 | -1.0 | -0.1 | -0.1 | 0.6 | 0.4 | 0.4 | 0.1 | -0.4 | -0.5 | 0.0 |
| Light reinforcement 1 | 0.1 | 0.1 | 0.2 | -0.4 | 0.3 | 0.3 | -0.1 | -0.4 | 0.5 | -0.4 | -0.5 | -0.3 | -0.4 |
| Reaction time mean | 0.1 | 0.1 | 0.4 | -0.3 | -0.4 | -0.4 | 0.1 | 0.1 | 0.7 | -0.2 | 0.1 | 0.1 | -0.6 |
| Reaction time mean AUC | 0.1 | 0.2 | 0.5 | -0.4 | -0.6 | -0.6 | 0.2 | 0.3 | 0.7 | -0.1 | 0.0 | -0.0 | -0.6 |
| Pavlov. Cond. lever latency | 0.1 | 0.2 | 0.6 | -0.4 | 0.0 | 0.0 | -0.0 | -0.5 | -0.0 | -0.3 | -0.8 | -0.7 | -0.3 |
| Cocaine induced anxiety | 0.1 | 0.1 | 0.3 | 0.2 | 0.0 | 0.0 | -0.4 | -0.4 | 0.4 | -0.4 | 0.1 | 0.4 | -0.5 |
| Condit. Reinf. lever presses | 0.1 | 0.2 | 0.4 | 0.4 | -0.2 | -0.2 | -0.1 | 0.2 | -0.7 | 0.4 | 0.6 | 0.5 | 0.3 |
| Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.4 | -0.1 | 0.2 | 0.2 | -0.2 | -0.5 | 0.5 | -0.6 | -0.4 | -0.0 | -0.5 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | -0.4 | -0.5 | -0.5 | 0.3 | 0.4 | 0.1 | 0.3 | -0.0 | -0.2 | 0.3 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.4 | 0.1 | 0.0 | 0.0 | 0.1 | -0.1 | -0.6 | 0.2 | -0.4 | -0.7 | 0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.2 | -0.2 | -0.3 | -0.3 | 0.2 | 0.5 | 0.0 | 0.3 | 0.4 | 0.2 | 0.2 |
| Bone: maximum diameter | 0.1 | 0.2 | 0.6 | 0.1 | 0.1 | 0.1 | -0.2 | -0.0 | 0.7 | -0.5 | 0.4 | 0.7 | -0.1 |
| Bone: periosteal estimation | 0.1 | 0.3 | 0.9 | -0.5 | -0.9 | -0.9 | 0.5 | 0.4 | 0.2 | 0.1 | -0.3 | -0.2 | 0.5 |
| Bone: tissue strength | 0.1 | 0.1 | 0.4 | -0.5 | -0.1 | -0.1 | 0.5 | 0.6 | 0.1 | 0.2 | 0.0 | -0.1 | 0.6 |
| Distance traveled before self-admin | 0.1 | 0.1 | 0.4 | 0.2 | 0.2 | 0.2 | -0.1 | 0.3 | 0.1 | 0.2 | 0.6 | 0.6 | 0.3 |
| Distance traveled after self-admin | 0.1 | 0.1 | 0.3 | 0.0 | 0.1 | 0.1 | -0.1 | 0.2 | 0.3 | -0.1 | 0.4 | 0.5 | 0.1 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.1 | 0.1 | 0.1 | 0.4 | 0.4 | -0.3 | -0.2 | -0.3 | -0.1 | 0.1 | 0.1 | -0.1 |
| Time in closed arm before self-admin | 0.1 | 0.2 | 0.5 | -0.5 | -0.4 | -0.4 | 0.5 | 0.5 | 0.7 | 0.1 | -0.1 | -0.2 | 0.2 |
| Time in closed arm after self-admin | 0.1 | 0.1 | 0.4 | -0.2 | -0.2 | -0.2 | 0.1 | 0.1 | -0.6 | 0.3 | -0.0 | -0.2 | 0.4 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.4 | -0.1 | 0.0 | 0.0 | 0.1 | 0.5 | 0.6 | -0.0 | 0.5 | 0.6 | 0.1 |
| Delay disc. indifference point, 24s delay | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | -0.3 | -0.3 | -0.5 | -0.1 | -0.2 | -0.2 | -0.1 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.2 | -0.4 | -0.5 | -0.5 | 0.3 | 0.1 | 0.4 | -0.1 | -0.1 | 0.1 | 0.1 |
| Total resting periods, locomotor time 2 | 0.1 | 0.2 | 0.4 | 0.1 | 0.1 | 0.1 | 0.2 | 0.6 | -0.5 | 0.6 | 0.5 | 0.1 | 0.5 |
| Fe content in liver | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.3 | -0.5 | 0.1 | 0.2 | -0.2 | 0.5 | 0.5 | -0.2 |
| Delay discounting total patch changes 0 sec | 0.0 | 0.1 | 0.2 | -0.3 | 0.4 | 0.4 | -0.0 | -0.1 | 0.2 | -0.2 | -0.1 | -0.0 | -0.4 |
| Locomotion distance, session 3 | 0.0 | 0.0 | 0.0 | -0.2 | -0.1 | -0.1 | 0.1 | 0.1 | 0.0 | -0.0 | -0.1 | 0.0 | -0.0 |
| Condit. Reinf. active-inactive response ratio | 0.0 | 0.0 | 0.2 | -0.3 | -0.1 | -0.1 | 0.3 | 0.4 | -0.3 | 0.1 | 0.0 | 0.0 | 0.1 |
| Pavlov. Cond. index score | 0.0 | 0.1 | 0.1 | -0.3 | -0.3 | -0.3 | 0.2 | 0.3 | 0.3 | 0.1 | 0.2 | 0.1 | 0.1 |
| Pavlov. Cond. lever contacts | 0.0 | 0.0 | 0.1 | -0.1 | -0.3 | -0.3 | 0.1 | 0.2 | -0.2 | 0.2 | 0.0 | -0.2 | 0.1 |
| Pavlov. Cond. response bias | 0.0 | 0.1 | 0.2 | -0.2 | -0.2 | -0.2 | -0.1 | 0.1 | 0.4 | -0.1 | 0.2 | 0.4 | -0.2 |
| Delta distance traveled before/after self-admin | 0.0 | 0.0 | 0.0 | -0.1 | 0.2 | 0.2 | -0.1 | -0.2 | 0.1 | -0.2 | -0.0 | 0.1 | -0.2 |
| Time to tail flick, test, after self-admin | 0.0 | 0.1 | 0.1 | 0.1 | 0.4 | 0.4 | -0.2 | -0.2 | 0.1 | -0.2 | 0.1 | 0.2 | -0.2 |
| Latency to leave start box in cocaine runway, M | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.3 | 0.2 | 0.2 | 0.1 | 0.1 | 0.0 | -0.0 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.