Gal3st3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000028743	0.06	0.05	4.5e-03	0.01	0.02	0.02	0.01	1.1e-01	2.9e-02	3.0e-02	1.4e-01
2	Brain	mRNA stability	ENSRNOG00000028743	0.03	0.02	1.0e-03	0.03	0.03	0.03	0.03	5.0e-04	7.2e-04	7.1e-04	3.7e-04
3	NAcc	gene expression	ENSRNOG00000028743	0.09	0.06	1.9e-06	0.09	0.07	0.06	0.07	4.6e-07	3.7e-06	5.9e-05	3.1e-06
4	PL	gene expression	ENSRNOG00000028743	0.03	0.02	8.7e-03	0.03	0.03	0.03	0.03	1.3e-03	2.1e-03	4.1e-03	1.6e-03
5	PL	mRNA stability	ENSRNOG00000028743	0.06	0.04	8.3e-05	0.04	0.05	0.03	0.04	3.0e-04	1.0e-04	1.3e-03	5.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	1.3	4.1	7.6	0.3	1.1	2.5	2.8	-2.3
BMI without tail	0.5	1.1	1.8	0.1	1.0	1.2	1.3	-1.2
Body weight	2.9	12.4	16.9	2.9	-1.8	4.1	4.1	-4.1
Epididymis fat weight	3.1	7.3	8.4	-2.7	2.3	-2.9	-2.8	2.8
Glucose	2.9	4.4	5.9	-2.4	2.3	-1.7	-1.9	2.1
Heart weight	3.4	4.8	5.7	-2.2	2.0	-2.0	-2.4	2.4
Left kidney weight	0.5	1.5	2.1	-1.0	1.0	-1.3	-1.5	1.3
Right kidney weight	0.1	0.1	0.3	-0.1	-0.3	-0.5	-0.5	0.4
Tail length	1.2	3.5	6.0	2.4	-2.2	1.5	1.3	-1.7
Length with tail	2.9	10.7	12.3	3.5	-3.2	3.2	3.0	-3.3
Length without tail	3.1	6.7	7.4	2.4	-2.5	2.6	2.7	-2.7
Liver weight, left	0.1	0.1	0.3	-0.1	0.2	-0.6	-0.4	0.3
Liver weight, right	0.0	0.1	0.2	0.0	0.2	-0.4	-0.3	0.2
Parametrial fat weight	3.4	6.7	7.6	-2.7	2.7	-2.4	-2.6	2.5
Retroperitoneal fat weight	5.8	19.1	21.6	-4.2	3.8	-4.6	-4.5	4.6
Intraocular pressure	0.5	0.7	1.6	-0.4	-0.4	-1.0	-1.2	0.9
Extensor digitorum longus weight	7.0	27.9	36.1	4.8	-3.2	6.0	6.0	-5.9
Soleus weight	3.9	11.2	14.2	-2.8	2.7	-3.7	-3.8	3.6
Tibialis anterior weight	11.7	40.2	46.8	6.3	-5.1	6.6	6.7	-6.8
Tibia length	1.3	3.7	4.7	1.8	-2.2	1.8	1.8	-1.9
Number of licking bursts	0.3	0.3	0.5	0.4	-0.4	0.7	0.7	-0.6
Food consumed during 24 hour testing period	0.2	0.2	0.8	0.4	-0.9	0.4	0.2	-0.2
Times rat made contact with spout	0.3	0.4	0.8	0.3	-0.1	0.9	0.7	-0.6
Mean time between licks in bursts	0.5	0.7	1.0	1.0	-0.8	0.6	0.8	-0.8
Mean num. licks in bursts	0.2	0.2	0.3	-0.5	0.5	-0.4	-0.5	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.6	-0.2	-0.4	-0.3	0.0
Water consumed over 24 hours	0.8	0.9	1.3	0.8	-0.9	1.1	1.0	-0.9
Indifference point 0 sec	0.1	0.1	0.2	-0.5	0.2	-0.3	-0.2	0.3
Indifference point AUC	3.5	4.1	5.1	1.9	-1.8	1.9	2.2	-2.3
Indifference point function ln k	7.9	11.2	14.2	-2.7	2.9	-3.6	-3.8	3.6
Indifference point function log k	7.9	11.2	14.2	-2.7	2.9	-3.6	-3.8	3.6
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.2	0.1
Delay discounting total patch changes 12 sec	4.2	5.5	8.3	2.0	-1.6	2.4	2.9	-2.7
Delay discounting total patch changes 18 sec	0.3	0.5	0.8	0.4	-0.3	0.8	0.9	-0.8
Delay discounting total patch changes 24 sec	2.8	3.6	4.2	1.8	-1.9	1.7	2.0	-1.9
Delay discounting total patch changes 6 sec	0.9	1.4	2.4	0.8	-0.7	1.3	1.6	-1.3
Delay discounting time to switch 0 sec	1.2	1.9	4.2	0.2	0.2	2.1	1.7	-1.5
Delay discounting water rate 0 sec	2.8	4.4	8.2	-1.0	0.3	-2.9	-2.7	2.4
Delay discounting water rate 12 sec	6.2	9.3	15.2	-1.7	1.2	-3.8	-3.9	3.5
Delay discounting water rate 18 sec	2.4	3.1	4.4	-1.2	1.2	-2.0	-2.0	2.1
Delay discounting water rate 24 sec	3.0	4.2	6.7	-1.2	0.8	-2.6	-2.6	2.4
Delay discounting water rate 6 sec	2.2	3.3	5.6	-0.8	0.7	-2.3	-2.4	2.1
Locomotor activity	0.9	1.4	2.6	-0.5	0.2	-1.5	-1.6	1.4
Locomotor testing distance	1.3	2.2	4.0	-0.6	0.5	-1.8	-2.0	1.8
Locomotor testing rearing	1.6	2.5	3.8	-1.2	0.8	-1.7	-1.9	1.9
Light reinforcement 1	0.1	0.2	0.4	-0.2	-0.0	-0.7	-0.6	0.5
Light reinforcement 2	0.7	0.9	1.5	-0.9	0.4	-1.0	-1.2	1.1
Reaction time number correct	0.5	0.7	1.2	1.1	-1.0	0.6	0.6	-0.8
Reaction time mean minus median	3.0	4.0	6.6	1.4	-1.5	2.6	2.1	-2.1
Reaction time mean minus median AUC	2.2	2.8	4.1	1.5	-1.4	2.0	1.6	-1.7
Reaction time num false alarms	0.1	0.1	0.3	0.4	0.1	-0.5	-0.4	0.2
Reaction time num false alarms AUC	0.2	0.3	0.8	0.9	-0.2	0.2	0.3	-0.5
Reaction time trials correct on left	0.5	0.7	1.2	1.1	-1.0	0.6	0.6	-0.8
Reaction time trials on left	0.6	0.9	1.5	1.2	-1.1	0.7	0.7	-0.9
Reaction time mean	0.0	0.1	0.2	-0.0	-0.2	0.4	0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.2	-0.2	-0.0	0.4	0.1	-0.1
Median of all reaction times	0.1	0.1	0.2	-0.5	0.3	-0.1	-0.3	0.3
Reaction time omissions	1.6	2.2	3.9	1.3	-0.8	2.0	1.4	-1.6
Reaction time false alarm rate	0.1	0.1	0.2	0.1	0.4	-0.3	-0.4	0.2
Reaction time premature initiation rate	2.5	3.3	4.0	2.0	-1.7	1.7	1.8	-1.9
Reaction time premature initiations	4.4	6.3	7.9	2.8	-2.5	2.3	2.4	-2.6
Std. dev. reaction times	0.9	1.2	2.3	0.8	-0.9	1.5	1.1	-1.1
Reaction time trials completed	0.6	0.9	1.5	1.2	-1.1	0.7	0.7	-0.9
Reaction time trials AUC	0.4	0.6	1.0	1.0	-0.9	0.4	0.5	-0.7
Social response proportion	0.8	0.9	1.4	0.5	-0.9	1.2	1.0	-0.9
Social responses	0.5	0.6	1.1	0.7	-1.0	0.8	0.7	-0.6
Social time	0.5	0.7	1.0	0.8	-1.0	0.8	0.8	-0.7
Conditioned locomotion	2.0	2.4	2.9	1.7	-1.2	1.6	1.5	-1.7
Cocaine response after cond. corrected	1.3	1.5	1.9	-0.9	1.2	-1.3	-1.4	1.3
Cocaine response after cond. not corrected	1.1	1.2	1.5	-0.9	1.0	-1.1	-1.2	1.2
Cocaine response before conditioning	0.5	0.7	1.0	0.4	-0.8	1.0	0.9	-0.8
Saline control response	3.6	4.7	6.1	1.9	-1.8	2.3	2.5	-2.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	-0.9	0.3	-0.3	-0.3	0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.6	-1.3	0.7	-0.8	-0.7	1.0
Condit. Reinf. active responses	0.1	0.2	0.5	-0.7	0.3	0.3	0.2	0.1
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.1	0.2	0.7	0.6	-0.4
Condit. Reinf. lever presses	2.0	2.8	4.3	1.0	-1.2	2.0	2.1	-1.7
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.4	-0.2	0.6	0.6	-0.2
Pavlov. Cond. lever latency	0.4	0.6	0.9	-0.5	0.6	-0.9	-0.9	0.8
Pavlov. Cond. magazine entry latency	3.1	3.6	5.7	1.2	-0.9	2.3	2.4	-2.1
Pavlov. Cond. change in total contacts	1.4	2.0	3.4	0.6	-0.8	1.8	1.8	-1.5
Pavlov. Cond. index score	2.1	2.7	4.3	1.0	-0.9	2.0	2.1	-1.8
Pavlov. Cond. latency score	1.7	2.2	3.5	0.9	-0.8	1.9	1.9	-1.6
Pavlov. Cond. lever contacts	0.6	0.9	1.1	0.8	-1.1	0.9	0.9	-0.9
Pavlov. Cond. magazine entry number	5.5	6.8	10.2	-1.8	1.6	-3.1	-3.2	2.9
Pavlov. Cond. intertrial magazine entries	1.1	1.5	2.1	-1.0	0.8	-1.4	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.3	5.1	1.1	-1.1	2.2	2.3	-2.0
Pavlov. Cond. response bias	1.7	2.3	3.2	1.1	-1.2	1.8	1.8	-1.6
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.1	-0.1	-0.5	-0.3	0.4
Conditioned reinforcement - inactives	5.0	5.6	7.5	-2.2	1.3	-2.7	-2.6	2.7
Conditioned locomotion	6.6	7.9	11.7	-2.2	1.5	-3.4	-3.2	3.2
Intermittent access intake day 1-15 change	0.2	0.2	0.4	-0.1	-0.4	-0.5	-0.6	0.5
Intermittent access intake escalation	0.2	0.2	0.4	-0.3	-0.0	-0.6	-0.6	0.6
Intermittent access intake escalation 2	0.2	0.2	0.4	0.2	-0.6	-0.5	-0.4	0.2
Intermitt. access day 1 inactive lever presses	2.1	2.3	3.0	-1.6	1.1	-1.4	-1.7	1.7
Intermitt. access day 15 inactive lever presses	1.6	1.8	2.5	-1.4	0.9	-1.4	-1.3	1.6
Intermitt. access escalation Index	4.9	4.4	5.4	-2.1	2.3	-2.1	-1.8	2.1
Intermittent access day 1 total infusions	8.0	9.1	12.3	-3.4	3.5	-2.6	-2.4	3.0
Intermittent access day 15 total infusions	7.7	8.6	10.5	-3.1	2.7	-2.8	-2.8	3.2
Intermittent access terminal intake (last 3 days)	5.7	6.2	7.6	-2.8	2.4	-2.3	-2.3	2.7
Intermittent access total infusions	5.5	6.1	8.3	-2.9	2.8	-2.0	-1.9	2.6
Intermittent access day 1 locomotion	5.9	6.0	10.4	-2.8	3.2	-1.8	-1.8	2.3
Intermittent access day 15 total locomotion	4.9	5.2	6.3	-2.5	2.1	-2.1	-2.1	2.5
Intermittent access total locomotion	8.3	9.3	12.4	-3.5	3.4	-2.7	-2.5	3.1
Intermittent access standard deviation	0.7	0.8	1.1	-0.7	0.5	-1.0	-1.0	1.0
Cocaine induced anxiety	0.0	0.0	0.0	0.2	-0.2	0.0	-0.1	-0.1
Post-drug Anxiety	1.9	2.1	3.4	1.5	-1.9	1.2	1.1	-1.5
Baseline Anxiety	3.1	3.2	3.9	1.8	-2.0	1.5	1.8	-1.9
Lifetime Intake	5.2	5.8	8.4	-2.8	2.9	-1.9	-1.8	2.4
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.8	0.8	-0.5	-0.3	0.6
Incentive Sensitization - Breakpoint	0.6	0.6	0.9	-0.9	0.8	-0.6	-0.5	0.8
Progressive ratio test 1 active lever presses	2.8	2.9	3.5	-1.7	1.6	-1.7	-1.6	1.9
Progressive ratio test 1 breakpoint	2.3	2.4	3.0	-1.5	1.4	-1.6	-1.5	1.7
Progressive ratio test 1 inactive lever presses	1.4	1.5	1.7	-1.3	1.2	-1.2	-1.1	1.3
Progressive ratio test 2 active lever presses	3.9	4.2	5.2	-2.2	1.9	-2.0	-1.8	2.3
Progressive ratio test 2 breakpoint	4.4	4.9	6.4	-2.1	1.8	-2.3	-2.2	2.5
Progressive ratio test 2 inactive lever presses	8.9	10.3	12.5	-3.4	2.7	-3.3	-3.1	3.5
Total sessions with >9 infusions	2.3	2.6	4.4	-1.7	2.1	-1.2	-1.3	1.5
Short access day 1 total inactive lever presses	4.2	4.7	6.3	-2.2	1.9	-2.5	-2.0	2.3
Short access day 10 total inactive lever presses	2.9	3.2	4.2	-1.6	1.4	-1.9	-2.0	2.0
Short access day 1 total infusions	4.9	5.2	8.6	-2.6	2.9	-1.7	-1.7	2.2
Short access day 10 total infusions	3.5	3.9	8.8	-2.5	3.0	-1.1	-0.9	1.6
Short access total infusions	2.6	2.9	6.0	-2.0	2.5	-1.2	-1.0	1.5
Short access day 1 locomotion	3.4	3.6	6.8	-2.2	2.6	-1.2	-1.2	1.9
Short access day 10 total locomotion	2.8	3.1	5.9	-2.0	2.4	-1.2	-1.1	1.6
Short access total locomotion	2.6	2.7	5.7	-1.9	2.4	-1.0	-0.9	1.4
Compulsive drug intake	3.2	3.2	4.2	2.1	-1.7	1.7	1.6	-1.9
One hour access (0.3 mA shock)	9.0	10.5	13.4	-3.2	2.7	-3.2	-3.4	3.7
One hour access (shock baseline)	8.2	9.5	12.1	-3.2	2.5	-3.0	-3.1	3.5
Number of responses in last shaping day	0.8	0.8	1.2	-0.7	0.6	-1.0	-1.0	1.1
Context. condit. distance diff. score	2.0	2.5	2.9	-1.4	1.3	-1.7	-1.7	1.7
Locomotion velocity, session 1	0.0	0.1	0.2	0.4	-0.3	0.0	0.1	-0.1
Locomotion distance, session 1	0.3	0.4	0.8	-0.1	0.6	0.8	0.9	-0.5
Locomotion velocity, session 2	2.2	2.6	4.0	1.2	-0.5	2.0	2.0	-1.8
Locomotion distance, session 2	0.5	0.7	1.3	0.3	0.5	1.1	1.1	-0.9
Locomotion velocity, session 3	0.4	0.4	1.3	-0.7	1.2	-0.3	-0.2	0.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	0.1
Stereotopy head waving bouts, day 3	1.1	1.4	2.1	-1.2	1.5	-1.0	-1.1	1.0
Stereotopy head waving duration, day 3	1.3	1.6	1.8	-1.3	1.3	-1.2	-1.3	1.3
Locomotion velocity, session 7	1.1	1.2	3.4	-1.2	1.8	-0.5	-0.4	0.7
Locomotion distance, session 7	0.2	0.3	1.1	-0.3	1.1	-0.1	-0.0	0.1
Stereotopy head waving bouts, day 7	0.4	0.4	1.0	-1.0	0.5	-0.5	-0.5	0.6
Stereotopy head waving duration, day 7	0.4	0.5	1.1	-0.0	-0.2	1.0	0.9	-0.8
Locomotion velocity, session 8	1.2	1.4	1.7	1.3	-1.1	1.1	1.2	-1.2
Locomotion distance, session 8	0.4	0.5	1.2	-0.8	1.1	-0.5	-0.5	0.6
Degree of sensitization distance	0.2	0.2	0.6	-0.3	0.8	-0.0	0.0	0.1
Degree of sensitization stereotypy	0.3	0.3	0.5	0.0	-0.4	0.7	0.7	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.0	0.2	0.7	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	0.1	0.4	0.2	-0.1
Condit. Reinf. active responses	0.1	0.1	0.3	-0.1	0.4	0.5	0.4	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.3	0.6	-0.1	-0.0	0.1
Incentive salience index mean	0.3	0.3	0.7	0.0	0.5	0.9	0.7	-0.5
Condit. Reinf. lever presses	0.3	0.4	0.7	0.4	0.1	0.8	0.7	-0.7
Time in familiar zone, hab. session 1	0.4	0.4	0.7	-0.8	0.8	-0.4	-0.4	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.3	-0.4	-0.5	-0.5	0.3
Total zone transitions, hab. session 1	0.6	0.9	1.5	0.7	-0.3	1.2	1.2	-1.1
Total locomotion distance, hab. session 1	0.5	0.7	1.4	-0.9	1.2	-0.7	-0.7	0.7
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.4	0.8	-0.2	-0.2	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.4	0.6	-0.2	-0.0	-0.0	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.5	0.4	0.1	0.2	0.0
Total zone transitions, hab. session 2	0.7	0.9	1.7	-0.3	0.6	1.2	1.3	-0.8
Total locomotion distance, hab. session 2	0.6	0.8	2.4	-1.1	1.6	-0.2	-0.2	0.4
Locomotion velocity, hab. session 2	0.8	1.0	2.8	-1.3	1.7	-0.4	-0.4	0.6
Novel to familiar place preference ratio	0.6	0.6	1.1	0.3	-0.6	1.0	1.0	-0.9
Novelty place preference	0.2	0.2	0.4	-0.1	-0.3	0.5	0.6	-0.5
Time in novel zone, NPP test	0.1	0.1	0.3	-0.1	-0.2	0.4	0.5	-0.4
Total zone transitions, NPP test	1.4	2.0	3.4	0.8	-0.5	1.8	1.8	-1.6
Total locomotion distance, NPP test	0.1	0.2	0.6	-0.3	0.8	0.1	0.1	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.5	-0.2	0.7	0.3	0.2	-0.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.5	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	-0.7	0.8	0.2	0.3	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.5	0.5	0.2	0.1	-0.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.0	0.1	0.3	0.2	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	0.4	0.1	0.1	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	0.3	0.0	-0.0	-0.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.3	0.4	-0.5	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.1	-0.1	-0.5	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.1	0.0	0.5	0.5	-0.5
Pavlov. Cond. response bias	0.0	0.1	0.1	0.1	-0.1	0.3	0.3	-0.3
Bone: apparent density	0.3	0.5	0.7	-0.7	0.6	0.8	0.8	-0.3
Bone surface	2.7	4.8	8.0	1.0	-1.3	2.8	2.8	-2.3
Bone volume	0.8	1.3	2.7	-0.0	-0.4	1.6	1.6	-1.1
Bone: connectivity density	1.3	2.0	4.0	0.3	-0.3	1.9	2.0	-1.5
Bone: cortical apparent density	0.3	0.3	0.5	0.7	-0.5	0.6	0.6	-0.7
Bone: cortical area	0.9	1.4	1.6	1.2	-0.9	1.3	1.3	-1.3
Bone: cortical porosity	0.0	0.1	0.1	-0.3	0.3	0.2	0.2	-0.1
Bone: cortical porosity	0.2	0.3	0.5	0.2	-0.2	0.7	0.6	-0.6
Bone: cortical thickness	4.2	7.0	9.1	3.0	-2.2	2.6	2.5	-2.8
Bone: cortical thickness	1.4	1.6	3.0	1.7	-1.0	1.2	1.0	-1.3
Bone: cortical tissue density	0.4	0.5	0.6	0.8	-0.6	0.6	0.6	-0.8
Bone: elastic displacement	0.4	0.4	0.9	0.3	-0.2	-0.8	-1.0	0.7
Bone: elastic work	1.3	1.7	3.0	1.7	-1.1	1.1	1.1	-1.3
Bone: endosteal estimation	1.5	3.3	5.1	-2.3	2.0	-1.5	-1.4	1.7
Bone: endosteal perimeter	1.9	3.9	7.1	-2.7	1.9	-1.6	-1.5	2.0
Bone: final force	2.5	4.0	5.5	1.6	-1.5	2.3	2.3	-2.2
Bone: final moment	2.1	3.5	4.8	1.5	-1.4	2.1	2.2	-2.0
Bone: marrow area	1.6	3.5	5.3	-2.3	2.1	-1.6	-1.5	1.8
Bone: maximum diameter	0.1	0.3	0.5	0.3	-0.7	0.5	0.5	-0.4
Bone: maximum force	2.3	4.1	6.8	1.1	-0.8	2.6	2.6	-2.2
Bone: maximum moment	2.0	3.5	5.9	1.0	-0.7	2.4	2.4	-2.1
Bone: minimum diameter	1.7	3.1	5.3	-2.3	2.3	-1.2	-1.1	1.5
Bone: periosteal estimation	0.1	0.1	0.3	-0.5	0.5	-0.1	-0.0	0.2
Bone: periosteal perimeter	0.0	0.1	0.2	-0.3	0.0	0.4	0.4	-0.1
Bone: post-yield work	1.3	1.8	4.1	-2.0	2.0	0.6	0.6	0.1
Bone: stiffness	1.6	2.6	4.7	0.6	-0.6	2.1	2.2	-1.8
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2	-0.1
Bone: trabecular number	0.3	0.5	0.9	-0.5	0.1	1.0	1.0	-0.5
Bone: trabecular spacing	0.2	0.2	0.4	-0.0	0.4	-0.6	-0.6	0.5
Bone: trabecular thickness	0.7	0.9	1.9	-1.4	1.1	-0.6	-0.6	0.9
Bone: trabecular tissue density	3.0	4.2	6.0	-1.6	1.2	-2.4	-2.4	2.2
Breakpoint value in progressive ratio session	3.3	3.6	4.6	1.7	-1.5	2.0	2.1	-2.1
Distance traveled before self-admin	0.3	0.3	0.5	0.4	-0.6	0.5	0.6	-0.7
Distance traveled after self-admin	0.1	0.2	0.3	0.3	-0.5	0.2	0.4	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.6	0.0	0.1	0.2	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.1	-0.6	0.1	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.7	0.8	1.0	0.9	-1.0	0.8	0.8	-0.9
Extinction: sum of active levers before priming	3.5	3.6	5.2	1.4	-0.9	2.1	2.3	-2.3
Active lever presses in extinction session 6	3.2	3.0	3.7	1.9	-1.9	1.4	1.7	-1.8
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.0	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.2	0.0	-0.1
Time in closed arm before self-admin	0.0	0.0	0.1	-0.3	-0.0	0.3	-0.0	0.0
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	0.4	0.2	-0.1	0.0
Time in open arm before self-admin	0.4	0.5	1.0	-0.3	1.0	-0.6	-0.7	0.7
Time in open arm after self-admin	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.4	0.3
Sum of active levers in priming session hrs 5-6	3.1	3.0	5.5	1.8	-2.3	1.2	1.5	-1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.1	0.1	0.7	0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.4	0.6	0.1	1.2	1.2	-1.1
Time to tail flick, test, before self-admin	1.3	1.3	3.2	-1.3	1.8	-0.5	-0.6	1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	-0.4	0.3	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.3	-0.0	0.8	0.7	-0.6
Delta time to tail flick, test, before/after SA	2.8	2.5	5.5	1.8	-2.3	1.1	0.8	-1.3
Ambulatory time before self-admin	0.3	0.3	0.4	0.2	-0.6	0.5	0.6	-0.6
Ambulatory time after self-admin	0.2	0.2	0.6	-0.8	0.4	-0.4	-0.3	0.4
Total heroin consumption	5.0	6.0	7.8	2.2	-1.9	2.5	2.7	-2.8
Area under the delay curve	0.5	0.5	1.3	-0.9	1.1	-0.3	-0.3	0.5
Delay disc. indifference point, 0s delay	1.4	1.5	2.7	-1.2	1.6	-1.2	-1.0	1.1
Delay disc. indifference point, 16s delay	1.2	1.2	2.1	-1.5	1.2	-0.6	-0.9	1.1
Delay disc. indifference point, 2s delay	0.2	0.3	0.3	-0.6	0.6	-0.5	-0.4	0.5
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.1	0.2	0.0	-0.3	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	-0.7	1.1	-0.5	-0.5	0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	-0.5	0.8	-0.3	-0.3	0.4
Delay discount exponential model param	0.3	0.3	0.9	0.7	-0.9	0.2	0.3	-0.4
Delay discount hyperbolic model param	0.3	0.3	0.7	0.6	-0.9	0.2	0.2	-0.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.0	-0.5	0.4	0.0	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.2	0.5	-0.1	0.0	0.1
Time >=10cm from walls, locomotor time 1	1.7	1.7	3.4	-1.8	1.6	-0.7	-0.9	1.2
Bouts of movement, locomotor time 1	1.6	1.8	2.7	1.0	-1.3	1.6	1.3	-1.3
Total resting periods, locomotor time 1	1.1	1.2	2.1	0.7	-1.0	1.5	1.1	-1.0
Rest time, locomotor task time 1	1.0	1.1	1.8	-0.7	0.4	-1.2	-1.3	1.2
Distance moved, locomotor task time 1	0.2	0.2	0.5	-0.3	0.7	0.2	0.5	-0.2
Vertical activity count, locomotor time 1	1.0	1.0	1.3	-0.9	0.8	-1.1	-1.1	1.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.3	0.2	0.0	0.0	0.0
Bouts of movement, locomotor time 2	0.6	0.6	1.0	0.6	-0.7	1.0	0.8	-0.8
Total resting periods, locomotor time 2	0.2	0.3	0.5	0.3	-0.4	0.7	0.6	-0.5
Rest time, locomotor task time 2	2.5	2.9	3.6	-1.5	1.5	-1.7	-1.9	1.8
Distance moved, locomotor task time 2	1.2	1.4	1.9	1.2	-1.0	1.0	1.4	-1.3
Vertical activity count, locomotor time 2	0.4	0.5	1.1	1.0	-1.1	0.0	0.1	-0.3
Weight adjusted by age	2.8	3.1	3.6	1.7	-1.5	1.9	1.8	-1.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	-0.6	0.6	0.0	-0.1	0.2
Locomotion in novel chamber	4.2	5.1	6.7	-2.2	1.6	-2.4	-2.4	2.6
Locomotion in novel chamber post-restriction	2.7	3.2	4.2	-1.6	1.4	-2.0	-1.9	2.0
Progressive ratio	1.0	1.1	2.1	0.0	0.4	1.5	1.4	-1.2
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.7	-0.5	0.7	0.6	-0.6
Seeking ratio, punishment vs. effort	0.8	0.9	1.8	-0.0	-0.1	-1.3	-1.3	1.1
Run reversals in cocaine runway, females	0.5	0.5	1.5	-0.1	1.2	0.6	0.7	-0.5
Run reversals in cocaine runway, males	0.4	0.3	0.8	0.8	-0.9	-0.3	-0.4	0.0
Latency to leave start box in cocaine runway	0.3	0.3	1.0	-0.8	1.0	0.1	-0.0	0.2
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	-0.5	0.7	0.2	0.1	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.0
Cd content in liver	1.0	1.1	1.9	-0.7	-0.0	-1.4	-1.2	1.2
Co content in liver	0.8	1.0	2.0	-0.1	0.1	-1.3	-1.4	1.1
Cu content in liver	0.3	0.3	0.6	0.3	0.1	0.8	0.7	-0.6
Fe content in liver	0.2	0.2	0.3	0.5	-0.5	0.4	0.4	-0.4
K content in liver	1.3	1.3	2.8	0.4	0.2	1.7	1.5	-1.2
Mg content in liver	0.6	0.7	1.8	-1.0	1.3	0.5	0.4	0.1
Mn content in liver	2.6	3.0	4.2	1.3	-1.4	2.1	1.9	-1.8
Na content in liver	1.4	1.4	1.6	1.2	-1.3	1.2	1.1	-1.2
Rb content in liver	2.3	2.8	3.5	-1.9	1.9	-1.7	-1.3	1.6
Se content in liver	0.1	0.1	0.3	-0.6	0.0	0.3	0.2	0.1
Sr content in liver	3.8	3.5	4.6	2.0	-2.2	1.5	1.7	-1.9
Zn content in liver	1.1	1.2	2.3	0.8	-0.4	1.5	1.2	-1.2