Hub : Traits

Delta time in open arm before/after self-admin

Delta time spent in the open arm during the first time point of elevated plus maze before self admin vs after self admin

Tags: Behavior · Heroin · Elevated plus maze

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	86716032	88108158	1	1	1.77e-07	1.45e-03	9.41e-02	Ube3d
2	chr12	987892	2366974	1	1	3.08e-09	2.47e-02	9.08e-01	Pcp2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Left kidney weight	2.15	1	0	0	0	1e+00	Ube3d
Intraocular pressure	8.82	1	0	0	0	1e+00	Ube3d
Indifference point function ln k	4.58	1	0	0	0	1e+00	Ube3d
Indifference point function log k	4.58	1	0	0	0	1e+00	Ube3d
Patch foraging total patch changes 24 sec	4.16	1	0	0	0	1e+00	Ube3d
Patch foraging water rate 6 sec	3.6	1	0	0	0	1e+00	Ube3d
Intermittent access total locomotion	4.57	1	0	0	0	1e+00	Pcp2
Progressive ratio test 1 inactive lever presses	9.71	1	0	0	0	1e+00	Ube3d
Progressive ratio test 2 inactive lever presses	7.87	1	0	0	0	1e+00	Ube3d
Short access day 1 total inactive lever presses	6.89	1	0	0	0	1e+00	Ube3d
Short access day 1 total infusions	17.39	1	0	0	0	1e+00	Ube3d
Short access day 1 locomotion	12.62	1	0	0	0	1e+00	Ube3d
Short access day 10 total locomotion	5.82	1	0	0	0	1e+00	Ube3d
Short access total locomotion	4.97	1	0	0	0	1e+00	Ube3d
Bone: cortical apparent density	3.94	1	0	0	0	1e+00	Ube3d
Delta time in closed arm before/after self-admin	11.2	1	0	0	0	1e+00	Pcp2
Time in closed arm after self-admin	15.89	1	0	0	0	1e+00	Pcp2
Time in open arm before self-admin	7.11	1	0	0	0	1e+00	Pcp2
Time in open arm after self-admin	8.57	2	0	0	0	1e+00	Pcp2 Ube3d
Time to tail flick, test, before self-admin	8.75	1	0	0	0	1e+00	Pcp2
Delta time to tail flick, test, before/after SA	6.05	1	0	0	0	1e+00	Pcp2
Delay disc. indifference point, 2s delay	5.54	1	0	0	0	1e+00	Ube3d
Delay disc. indifference point, 8s delay	7.72	1	0	0	0	1e+00	Ube3d
Rest time, locomotor task time 1	5.35	1	0	0	0	1e+00	Ube3d
Distance moved, locomotor task time 1	12.12	1	0	0	0	1e+00	Ube3d
Vertical activity count, locomotor time 1	24.17	1	0	0	0	1e+00	Ube3d
Total resting periods, locomotor time 2	5.38	1	0	0	0	1e+00	Ube3d
Distance moved, locomotor task time 2	7.23	1	0	0	0	1e+00	Ube3d
Vertical activity count, locomotor time 2	7.99	1	0	0	0	1e+00	Ube3d
Latency to leave start box in cocaine runway	8.28	1	0	0	0	1e+00	Ube3d
Latency to leave start box in cocaine runway, F	4.72	1	0	0	0	1e+00	Ube3d
Latency to leave start box in cocaine runway, M	5.67	1	0	0	0	1e+00	Ube3d
Sr content in liver	9.09	1	0	0	0	1e+00	Ube3d

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.06
Adipose	alternative TSS	0	0	1
Adipose	gene expression	1	0	0.97
Adipose	isoform ratio	0	0	0.98
Adipose	intron excision ratio	0	0	0.89
Adipose	mRNA stability	0	0	0.97
BLA	alternative polyA	0	0	1.08
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	0.96
BLA	isoform ratio	0	0	0.96
BLA	intron excision ratio	0	0	0.91
BLA	mRNA stability	0	0	0.96
Brain	alternative polyA	0	0	1.02
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	0.99
Brain	isoform ratio	0	0	0.97
Brain	intron excision ratio	1	0	0.99
Brain	mRNA stability	0	0	0.97
Eye	alternative polyA	0	0	0.88
Eye	alternative TSS	0	0	1.05
Eye	gene expression	0	0	0.9
Eye	isoform ratio	0	0	0.85
Eye	intron excision ratio	0	0	0.96
Eye	mRNA stability	0	0	1.08
IL	alternative polyA	0	0	1
IL	alternative TSS	0	0	0.89
IL	gene expression	0	0	0.96
IL	isoform ratio	0	0	0.98
IL	intron excision ratio	0	0	0.87
IL	mRNA stability	0	0	0.94
LHb	alternative polyA	0	0	0.97
LHb	alternative TSS	0	0	0.86
LHb	gene expression	0	0	0.93
LHb	isoform ratio	0	0	0.89
LHb	intron excision ratio	0	0	0.82
LHb	mRNA stability	0	0	0.92
Liver	alternative polyA	0	0	1.02
Liver	alternative TSS	0	0	0.91
Liver	gene expression	0	0	0.96
Liver	isoform ratio	0	0	0.94
Liver	intron excision ratio	0	0	0.9
Liver	mRNA stability	0	0	0.95
NAcc	alternative polyA	0	0	0.98
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	0.97
NAcc	isoform ratio	0	0	0.97
NAcc	intron excision ratio	0	0	0.95
NAcc	mRNA stability	0	0	0.97
OFC	alternative polyA	0	0	1.02
OFC	alternative TSS	0	0	0.97
OFC	gene expression	0	0	0.9
OFC	isoform ratio	0	0	0.92
OFC	intron excision ratio	0	0	0.84
OFC	mRNA stability	0	0	0.97
PL	alternative polyA	0	0	1.07
PL	alternative TSS	0	0	0.98
PL	gene expression	0	0	0.97
PL	isoform ratio	0	0	0.98
PL	intron excision ratio	0	0	0.96
PL	mRNA stability	0	0	0.97
pVTA	alternative polyA	0	0	0.97
pVTA	alternative TSS	0	0	0.99
pVTA	gene expression	0	0	0.97
pVTA	isoform ratio	0	0	0.93
pVTA	intron excision ratio	0	0	0.99
pVTA	mRNA stability	0	0	0.96
RMTg	alternative polyA	0	0	0.89
RMTg	alternative TSS	0	0	0.94
RMTg	gene expression	0	0	0.92
RMTg	isoform ratio	0	0	0.88
RMTg	intron excision ratio	0	0	1.06
RMTg	mRNA stability	0	0	0.87